Unreferenced stub auto yes date December 2009 Histotoxichypoxia also called histoxic hypoxia is the inability of cells to take up or utilize oxygen from the bloodstream, despite physiologically normal delivery of oxygen to such cells and tissues. Histotoxichypoxia results from tissue poisoning, such as that caused by alcohol , narcotics , cyanide which acts by inhibiting cytochrome oxidase , and certain other poison s like hydrogen sulfide byproduct of sewage and used in leather tanning . DEFAULTSORT HistotoxicHypoxia Category Diseases and disorders Category Oxygen Disease stub ... more details
wiktionary hypoxiaHypoxia may refer to Hypoxia environmental , reduced dissolved oxygen content of a body of water detrimental to aerobic organisms Hypoxia medical , a pathological condition in which the body as a whole or a region of the body is deprived of adequate oxygen supply Popular culture Hypoxia Benn Jordan song Hypoxia Benn Jordan song , a 2008 ambient song Hypoxia Delerium song Hypoxia Delerium song , a 1994 electronica song Hypoxia , a 2011 song from Pulse Thomas Giles album Pulse Thomas Giles album disambig de Hypoxie lt Hipoksija nl Hypoxie nds Hypoxie tr Hipoksi ... more details
Histotoxichypoxia in which quantity of oxygen reaching the cells is normal, but the cells ...SignSymptom infobox Name Hypoxia Image Cynosis.JPG Caption Cyanosis of the hand in someone with low oxygen ... eMedicine mult MeshID D000860 Hypoxia , or hypoxiation , is a Pathology pathological condition in which the body as a whole generalized hypoxia or a region of the body tissue hypoxia is deprived ... demand at the cellular level may result in a hypoxic condition. Hypoxia in which there is complete deprivation of oxygen supply is referred to as anoxia . Hypoxia differs from hypoxemia in that, in the latter ... & Wilkins pages 22 isbn 0683089366 ref It is possible to experience hypoxia and have a low oxygen content ... can easily lead to confusion, especially as hypoxemia is among the causes of hypoxia in hypoxemic hypoxia . Generalized hypoxia occurs in healthy people when they ascend to high altitude ... 03 05 ref Hypoxia also occurs in healthy individuals when breathing mixtures of gases with a low ... that control the amount of oxygen in the supplied air. A mild and non damaging intermittent hypoxia ... mechanisms of improved sea level ... PubMed Med Sci Sports Exerc. 2007 Sep 39 9 1600 9. ref Hypoxia ... to distribute oxygenated blood throughout the body, infants at risk of hypoxia are often placed inside ... . In humans, hypoxia is detected by chemoreceptors in the carotid body . This response does not control ... hypoxia is a generalized hypoxia, with an inadequate supply of oxygen to the body as a whole. The term hypoxemic hypoxia specifies hypoxia caused by low partial pressure of oxygen in arterial blood. In the other causes of hypoxia that follow, the partial pressure of oxygen in arterial blood is normal. Hypoxemic hypoxia may be due to Hypoventilation . Inadequate pulmonary minute ventilation e.g. ... from inhaled anesthesia to atmospheric air, due to the Fink effect , or diffusion hypoxia. Anemia ... of the effect of anaemia on oxygen content ref Hypoxia when the blood fails to deliver oxygen ... more details
of oxygen. Histotoxichypoxia . Oxygen is present in brain tissue but cannot be metabolized by the brain ...other uses hypoxia disambiguation Infobox disease Name Cerebral hypoxia Image Arteries beneath brain ... ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D002534 Cerebral hypoxia refers to a reduced .... There are four categories of cerebral hypoxia in order of severity they are diffuse cerebral hypoxia DCH , focal cerebral ischemia, cerebral infarction, and global cerebral ischemia. Prolonged hypoxia induces neuron al cell death via apoptosis resulting in a hypoxic brain injury. ref Malhotra R. et al. Hypoxia induces apoptosis via two independent pathways in Jurkat cells differential ... ref Classification Cerebral hypoxia is typically grouped into four categories depending on the severity and location of the brain s oxygen deprivation ref cite web url http www.answers.com topic hypoxia title Hypoxia work The Gale Encyclopedia of Neurological Disorders publisher The Gale Group, Inc ... artery br One cause of Hypoxic Anoxic Injury HAI . Diffuse cerebral hypoxia . A mild to moderate ... of the brain. Cerebral hypoxia can also be classified by the cause of the reduced brain oxygen ref cite web url http www.graylab.ac.uk groups advtec hypoxia hypoxia2.html title What is Hypoxia? date ... http www.graylab.ac.uk groups advtec hypoxia hypoxia2.html archivedate 2003 09 21 Retrieved on 2007 04 13 from Internet Archive Archive.org . ref Hypoxic hypoxia . Limited oxygen in the environment ... MEDIA approach issues mayjun05 hypoxiaexpert.htm title Are you a hypoxia expert? last Brooks ... provides hypoxia related safety tips for aviators working for the United States Navy aviators. ref mountain climbers and fire fighters are all at risk for this kind of cerebral hypoxia. The term ... of the windpipe all cause this sort of hypoxia. Severe asthmatics may also experience symptoms of hypoxic hypoxia. Hypemic hypoxia . Reduced brain function is caused by inadequate oxygen in the blood ... more details
Tumor hypoxia is the situation where tumor cell biology cells have been deprived of oxygen . As a tumor grows, it rapidly outgrows its blood supply, leaving portions of the tumor with regions where the oxygen concentration is significantly lower than in healthy tissues. Hypoxic tumor cells are usually resistant to radiotherapy and chemotherapy , ref W. A. Denny, Prodrug strategies in cancer therapy, Eur. J. Med. Chem., 2001, 36, 577 595 ref but they can be made more susceptible to treatment by increasing the amount of oxygen in them. Bioreductive prodrugs also play a significant part in dealing ... hypoxia can also be a result of the high degree of cell proliferation undergone in tumor tissue ... working to address tumor hypoxia Novacea, Inc., Proacta Inc. and Threshold Pharmaceuticals, Inc ... 302 Threshold Pharmaceuticals . These drug candidates target levels of hypoxia that are common in tumors ... agents and ultimately contribute to relapse. In the literature, hypoxia has been demonstrated ... response. ref Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix M. Hockel Canc. Res. 56 4509, 1996. ref ref Hypoxia in cancer significance and impact ... recent review articles summarize the current status of hypoxic cytotoxins hypoxia activated prodrugs . ref Exploiting tumor hypoxia in cancer treatment J.M. Brown and W.R. Wilson Nat.Rev.Canc.4,437, 2004. ref ref Hypoxia targeting the tumor R.G. Boyle and S. Travess Anticancer Agents Med. Chem. 64 281, 2006. ref ref Targeting tumors with hypoxia activated cytotoxins G.O. Ahn and M. Brown Frontiers ... as a chemo and radio sensitizing agent by enhancing tumor blood flow, thereby reducing tumor hypoxia ... Cancer Institute publisher Cancer.gov date accessdate 2011 12 21 ref See also Hypoxia medical Hypoxia References references Hypoxia driven selection of the metastatic phenotype Richard Sullivan, Charles H. Graham Cancer Metastatis Review 2007 26 319 331 DEFAULTSORT Tumor Hypoxia Category Oncology ... more details
For other uses of the term hypoxiaHypoxia disambiguation Hypoxic hypoxia is a result of insufficient oxygen available to the lungs. A blocked airway, a drowning or a reduction in partial pressure high altitude above 10,000 feet are obvious examples of how lungs can be deprived of oxygen. Some medical examples are abnormal pulmonary function or Respiration physiology respiratory obstruction, or a right to left shunt in the heart . Hypoxic hypoxia is seen in patients suffering from chronic obstructive pulmonary diseases Chronic obstructive pulmonary disease COPD , neuromuscular diseases or interstitial lung disease . Some symptoms of hypoxic hypoxia are Cyanosis Headache Decreased reaction time Impaired judgment time Euphoria Visual impairment Drowsiness Lightheaded or dizzy sensation Tingling in fingers and toes Numbness See also Pulmonology Oxygen Bibliography refbegin Flight Standards Service. Pilot s Handbook of Aeronautical Knowledge FAA Manual H 8083 25 . Washington, DC Federal Aviation Administration, U.S. Dept. of Transportation, 2001. ISBN 1 56027 540 5. refend med stub Category Respiratory diseases ... more details
Hypoxia , or oxygen depletion , is a phenomenon that occurs in aquatic environments as oxygen dissolved oxygen DO molecular oxygen dissolved in the water becomes reduced in concentration to a point where it becomes detrimental to aquatic organisms living in the system. Dissolved oxygen is typically expressed as a percentage of the oxygen that would dissolve in the water at the prevailing temperature and salinity both of which affect the solubility of oxygen in water see oxygen saturation and underwater . An aquatic system lacking dissolved oxygen 0 saturation is termed anaerobic, Reducing environment reducing , or Anoxic waters anoxic a system with low concentration&mdash in the range between ... of anoxic and hypoxic zones. Where hypoxia occurs Hypoxia can occur throughout the water .... Jr. Characterization of Hypoxia Topic 1 Report for the Integrated Assessment on Hypoxia in the Gulf ... products hypox t1final.pdf . Retrieved February 11, 2009. ref Hypoxia can also occur ... of Zoology volume 254 issue 1 pages 101 107 doi 10.1017 S0952836901000590 ref Causes of hypoxia ... , a process that further reduces DO in the water column. If oxygen depletion progresses to hypoxia ... is covered with crabs, fish, and clams apparently dead or dying from oxygen depletion. Hypoxia may ... may then become low enough for hypoxia to occur. Areas particularly prone to this include shallow waters ... Mobile Bay jubilee Jubilee photo from Mobile Bay Hypoxia may also be the explanation for periodic ... Off Oregon Coast 8 9 2006 ref Solutions To combat hypoxia, it is essential to reduce the amount ... . Bog chemistry In certain northern European sphagnum acidic bogs, a condition of hypoxia arises ... short term hypoxia journal Mar Ecol Prog Ser volume 88 pages 181 184 year 1992 doi 10.3354 meps088181 ... currupt capitol Kiel . External links http www.nos.noaa.gov products pubs hypox.html Hypoxia in the Gulf ... hypoxiaHypoxia in Oregon Waters http www.HowMuchAerationDoINeed.com How Much Aeration Do I Need Pollution ... more details
Infobox Disease Name Intrauterine hypoxia Image Placental infarct intermed mag.jpg Caption Micrograph of a placental infarct left of image , a cause of intrauterine hypoxia. H&E stain . DiseasesDB 1416 ... eMedicineTopic MeshID D001238 Uterus Intrauterine Hypoxia medical hypoxia IH , and birth asphyxia ... growth restriction IUGR may cause or be the result of hypoxia. Birth asphyxia may result due ... 21 pages 1077 85 year 1966 pmid 5933054 pmc 1935461 ref Intrauterine hypoxia and birth asphyxia can ... first5 EN last6 Krushinskaya first6 YV title The effects of ante and postnatal hypoxia on the central ... A title Intrauterine hypoxia and sudden infant death syndrome journal Acta medica Croatica casopis ... fetal hypoxia and sudden infant death syndrome interaction between maternal smoking and low hematocrit ... causes for intrauterine hypoxia IH . The most preventable cause is maternal smoking. Cigarette ... fetus. Among the negative effects are carbon monoxide induced tissue hypoxia and placental ... nervous system , leading to increased susceptibility to hypoxia induced brain damage. File MaternalCig.jpg thumb left 120px Maternal smoking, a preventable cause of intrauterine hypoxia. ref cite ... JC last2 Kaufmann first2 P title Oxygen and placental villous development origins of fetal hypoxia ... with in 48 hours of birth, is a form of Cerebral hypoxia hypoxic ischemic encephalopathy ... per 100,000 inhabitants in 2002 In the United States intrauterine hypoxia and birth asphyxia ... hypoxia has been shown to be a key factor is the third leading cause of death. The World Health ... ref Financial Costs Intrauterine hypoxia or birth asphyxia IH BA was the ninth most expensive medical ... CF last2 Morton first2 JS last3 Davidge first3 ST title Effects of hypoxia induced intrauterine ... condition treated in U.S. hospitals. 4 out of 10 linked to intrauterine hypoxia birth asphxia Cost ... weight 44,490 119,389 6. Cardiac and circulatory birth defects 35,960 101,412 9. Intrauterine hypoxia ... more details
Hypoxia Activated Prodrugs, or HAPs, target regions of tumor hypoxia within tumor cells. HAPs may offer the potential, alone and in combination with conventional chemotherapy, of improving cancer therapy. It is believed that tumor hypoxia contributes significantly to treatment failure and relapse among cancer patients because cells in the hypoxic zones of solid tumors resist traditional chemotherapy for at least two reasons first, most antitumor agents cannot penetrate beyond 50 100 micrometers from capillaries, ref Drug penetration in solid tumors A. Minchinton and I. Tannock Nature Reviews Cancer 6 583 592, 2006. ref thereby never reaching those cells in the hypoxic regions. Secondly, the lower nutrient and oxygen supply to cells in the hypoxic zones of tumors cause them to divide more slowly than their well oxygenated counterparts, so hypoxic tumor cells exhibit greater resistance to chemotherapies and radiation which target rapidly dividing cells or require oxygen for efficacy. Hypoxia also contributes to the invasive and metastatic phenotypes of aggressive cancers by promoting genetic instability and accelerating the accumulation of mutations that can ultimately give rise to drug resistance. ref Hypoxia and adaptive landscapes in the evolution of carcinogenesis R.J. Gillies and R.A. Gatenby Cancer Metastiasis Rev. 26 1573, 2007. ref ref Hypoxia driven selection of the metastatic phenotype R. Sullivan and C.H. Graham Cancer Metastasis Rev. 26 319, 2007. ref There are several companies developing HAPs Novacea, Inc., Proacta Inc. and Threshold Pharmaceuticals, Inc. These companies are developing the following drug candidates AQ4N Novacea , PR 104 Proacta and TH 302 Threshold Pharmaceuticals . References Reflist Category Experimental cancer drugs Category Oxygen biology stub ... more details
Baltic Sea hypoxia refers to low levels of oxygen in bottom waters, also known as Hypoxia environmental hypoxia , occurring regularly in the Baltic Sea . The total area of bottom covered with hypoxic waters with oxygen concentrations less than 2 mg l in the Baltic Sea has averaged 49,000 km2 over the last 40 years ref Conley, D.J., S. Bj rck, E. Bonsdorff, J. Carstensen, G. Destouni, B.G. Gustafsson, S. Hietanen, M. Kortekaas, H. Kuosa, H. E.M. Meier, B. M ller Karulis, K. Nordberg, A. Norkko, G. N rnberg, H. Pitk nen, N.N. Rabalais, R. Rosenberg, O.P. Savchuk, C.P. Slomp, M. Voss, F. Wulff, L. Zill n. 2009. Critical Review Hypoxia related processes in the Baltic Sea. Environ. Sci. Tech. 43 3412 3420. http pubs.acs.org doi pdf 10.1021 es802762a ref . The ultimate cause of hypoxia is excess ... hypoxia O2 2 ml l and black is the anoxic area with no oxygen left in the water. Figure from SMHI. Causes of hypoxia The rapid increase in Hypoxia environmental hypoxia in coastal areas around ..., hypoxia can occur In the Baltic Sea, the input of salt water from the North Sea through the Danish Straits is important in determining the area of hypoxia each year. Denser, saltier water comes into the Baltic ... of oxygen poor bottom waters with more brackish, lighter surface waters. Thus, large areas of hypoxia ... ref Zill n, L., D.J. Conley, T. Andr n, E. Andr n, and S. Bj rck. 2008. Past occurrences of hypoxia ... Baltic Sea called the Littorina Sea starting around 8,000 calendar years BP. Hypoxia disappeared for a period ... remained hypoxic for the last 100 years. The causes of the various periods of hypoxia are being scientifically ... low concentrations of oxygen ref Vaquer Sunyer, R. and C.M. Duarte. 2008. Thresholds of hypoxia ... oxygen leading to further hypoxia and more phosphorus is released from bottom sediments. This process ... Rabalais, M. Voss, L. Zill n. 2009. Viewpoint Tackling hypoxia in the Baltic Sea Is engineering ... www.balticsea2020.se Baltic Sea 2020 DEFAULTSORT Baltic Sea Hypoxia Category Baltic Sea ... more details
protein Name HIF1A hypoxia inducible factor 1, alpha subunit caption image width HGNCid 4910 Symbol HIF1A ... Q9HBZ2 PDB ECnumber Chromosome 1 Arm q Band 24 LocusSupplementaryData protein Name HIF3A hypoxia inducible ... Hypoxia inducible factors HIFs are transcription factors that respond to changes in available oxygen in the cellular environment, specifically, to decreases in oxygen, or Hypoxia medical hypoxia . ref name pmid18410568 cite journal author Smith TG, Robbins PA, Ratcliffe PJ title The human side of hypoxia inducible factor journal Br. J. Haematol. volume 141 issue 3 pages 325 34 year ... cite journal author Wang GL, Jiang BH, Rue EA, Semenza GL title Hypoxia inducible factor 1 is a basic ... GL title Dimerization, DNA binding, and transactivation properties of hypoxia inducible factor 1 ... Functions of the Per ARNT Sim domains of the hypoxia inducible factor journal J. Biol. Chem. volume ... proteins valign top Infobox protein family Symbol HIF 1 Name Hypoxia inducible factor 1 image ... width caption Structure of hypoxia inducible factor 1 alpha subunit. ref name pmid11959990 cite journal author Freedman SJ, Sun ZY, Poy F, et al. title Structural basis for recruitment of CBP p300 by hypoxia ... wikitable border 1 member gene protein HIF1A HIF 1 gene HIF1A HIF1A hypoxia inducible factor 1, alpha ... 2 HIF 3 gene HIF3A HIF3A hypoxia inducible factor 3, alpha subunit HIF 3 ARNT3 aryl hydrocarbon receptor nuclear translocator 3 Role The HIF signaling cascade mediates the effects of hypoxia, the state of low oxygen concentration, on the cell. Hypoxia often keeps cells from Cellular differentiation differentiating . However, hypoxia promotes the angiogenesis formation of blood vessels , and is important for the formation of a vascular system in embryo s, and cancer tumors. The hypoxia in wound ... Benizri cite journal author Benizri E, Ginouv s A, Berra E title The magic of the hypoxia signaling ... PA title Regulation of human metabolism by hypoxia inducible factor journal Proc. Natl. Acad. Sci ... more details
Patricia The distinction between hypoxemia, anemia and hypoxia While the term hypoxemia is limited to low oxygen in the blood , the more general term is Hypoxia medical hypoxia , which is an abnormally low oxygen content in any tissue or organ. It will be seen that hypoxemia can cause hypoxia the hypoxemic hypoxia other mechanisms for hypoxia also exist e.g. anemic hypoxia or histotoxichypoxia ... usage, hypoxemic hypoxia is sometimes informally given as hypoxic hypoxia . Disagreements exist concerning ... tissue hypoxia even though arterial blood in patent blood vessels is normal. There is less agreement ... 6th year 2002 publisher C.V. Mosby isbn 978 0323014304 Jacob Samuel and Cory Frankling, Hypoxemia and Hypoxia ... more details
wiktionary anoxia The term anoxia means a total decrease in the level of oxygen , an extreme form of hypoxia or low oxygen . The terms anoxia and hypoxia are used in various contexts Anoxic waters Anoxic event Dead zone ecology or hypoxic zones Hypoxia environmental Hypoxia medical See also Anoxia beetle Anoxia beetle , a genus of Scarabaeidae scarab beetle s Oxygen saturation , a relative measure of the oxygen dissolved or carried in a medium a measure of the severity of hypoxic conditions. Oxygen toxicity hyperoxia , the opposite condition of hypoxia, an excess of oxygen in body tissues. disambig ca An xia es Anoxia fr anoxie it Anossia ml ja pt An xia ... more details
Focal fatty liver FFL is localised or patchy process of lipid accumulation in the liver . It is likely to have different pathogenesis than non alcoholic steatohepatitis which is a diffuse process. FFL may result from altered venous flow to liver, Tissue biology tissue Hypoxia medical hypoxia and malabsorption of lipoprotein s. The condition has been increasingly recognised as sensitivity of Human abdomen abdominal imaging studies continues to improve. A fine needle biopsy is often performed to differentiate it from malignancy . Category Diseases of liver pathology stub ... more details
mergefrom Euler Liljestrand mechanism discuss Talk Hypoxic pulmonary vasoconstriction Merger proposal date May 2010 Hypoxic pulmonary vasoconstriction is a paradoxical, Physiology physiological phenomenon in which pulmonary arteries constrict in the presence of Hypoxia medical hypoxia low oxygen levels without hypercapnia high carbon dioxide levels , redirecting blood flow to Pulmonary alveolus alveoli with a higher oxygen content. The process might at first seem illogical, as low oxygen levels should theoretically lead to increased blood flow to the lungs to receive increased gaseous exchange. However, it is explained by the fact that constriction leads to redistribution of bloodflow to better ventilated areas of the lung, which increases the total area involved in gaseous exchange. This improves ventilation perfusion ratio and arterial oxygenation, but it less helpful in the case in long term whole body hypoxia. This is seen in COPD , at effects of high altitude on humans altitude and in heart failure . Several factors inhibit this process including increased cardiac output, hypocapnia , hypothermia , acidosis alkalosis , increased pulmonary vascular resistance, inhaled anesthetics , calcium channel blockers, PEEP, HFV, isoproterenol , nitrous oxide , and vasodilators . High altitude pulmonary edema main High altitude pulmonary edema Climbing tall mountains can induce full lung hypoxia due to decreased atmospheric pressure. This hypoxia causes hypoxic vasoconstriction that ultimately leads to high altitude pulmonary edema HAPE . For this reason, most climbers carry supplemental oxygen to prevent hypoxia, edema, and HAPE. The standard drug treatment of dexamethasone does not alter the hypoxia or the consequent vasoconstriction, but stimulates fluid reabsorption in the lungs to reverse the edema. External links http www.thoracic.org sections about ats assemblies pc journal club pages hypoxic pulmonary vasoconstriction december 2003.html American Thoracic Society htt ... more details
Unreferenced stub auto yes date December 2009 Astrocytosis astrogliosis is an abnormal increase in the number of astrocyte s due to the destruction of nearby neurons , typically because of hypoglycemia or oxygen deprivation Hypoxia medical hypoxia . It usually takes place in prion infections. It is especially prevalent in fatal familial insomnia , a prion infection affecting the thalamus and circadian rhythms. This manifests as astrocytic edema , Organ hypertrophy hypertrophy , proliferation, and increased motility. In the central nervous system , the proliferation of reactive astrocytes also leads to the formation of a glial scar . Astrogliosis is a major pathological finding in Amyotropic Lateral Sclerosis ALS . It is also sometimes a finding in sudden infant death syndrom SIDS . Category Nervous system Category Histopathology Pathology stub ... more details
Unreferenced stub auto yes date December 2009 Hyperoxia is excess oxygen or higher than normal partial pressure of oxygen. In medicine, it refers to excess oxygen in the lungs or other body tissues, which can be caused by breathing air or oxygen at pressures greater than normal atmospheric pressure. This kind of hyperoxia can lead to oxygen toxicity . In the environment, it refers to excess oxygen in a body of water or other habitat. See also Hypoxia medical Hypoxia Oxygen toxicity Category Oxygen Category Respiratory diseases Category Diving medicine Disease stub ... more details
Refimprove date December 2009 Orphan date February 2009 Neuroendocrine hyperplasia is a wikt progressive progressive hyperplasia hyperplastic process that ultimately results in wikt obliterate obliterative fibrosis of predominantly the lung pulmonary tree the lungs . It is characterized by tachypnea , Hypoxia medical hypoxia , and retractions . ref name Springerlink cite web url http www.springerlink.com content pw8x713728772g13 title Neuroendocrine cell hyperplasia of infancy NCHI publisher University of Cincinnati College of Medicine year 2006 ref There is no currently recognized treatment for the relentless progression of this disorder. References Reflist 3 DEFAULTSORT Neuroendocrine Hyperplasia Category Diseases and disorders Category Disease stubs Disease stub ... more details
context date January 2008 Biomed 101 is an agent binding to the leukotriene B4 receptor . This leads to reduced levels of interleukin 2 mediated Hypoxia medical hypoxia . Biomed 101 does not affect interleukin 2 antitumor activity. Biomed 101 is also in the process of being tested to see if it can help reduce the side effects of a drug called interleukin 2 IL 2 , already it has been found that Biomed 101 does not affect interleukin 2 antitumor activity meaning these two drugs can work to gather safely if the anti side effect property is found within Biomed 101 Citation needed date April 2009 . External links http www.cancer.gov Templates drugdictionary.aspx?CdrID 37882 National Cancer Institute Drug Dictionary Category Drugs Category Chemotherapeutic adjuvants Category Experimental cancer drugs ... more details
orphan date December 2008 HVR is the increase in ventilation physiology ventilation induced by Hypoxia medical hypoxia . It is initially elevated in lowland people who go to high altitude, although it reduces significantly over time as people acclimatize . Hypoxic Ventilatory Response HVR is a term used in the study of Anthropology pertaining to human adaptation and stresses of high altitude. Sources Stanford, Craig, John S. Allen, and Susan C. Anton. Biological Anthropology The Natural History of Humankind . 2nd ed. Upper Saddle River Prentice Hall Higher Education, 2008. 151 52. Category Abnormal respiration ... more details
PBB geneid 64344 Hypoxia inducible factor 3 alpha is a protein that in humans is encoded by the HIF3A gene . ref name pmid11573933 cite journal author Hara S, Hamada J, Kobayashi C, Kondo Y, Imura N title Expression and characterization of hypoxia inducible factor HIF 3alpha in human kidney suppression of HIF mediated gene expression by HIF 3alpha journal Biochem Biophys Res Commun volume 287 issue 4 pages 808 13 year 2001 month Sep pmid 11573933 pmc doi 10.1006 bbrc.2001.5659 ref ref name pmid11734856 cite journal author Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, Tanaka H, Cao Y, Berkenstam A, Poellinger L title Inhibitory PAS domain protein is a negative regulator of hypoxia inducible gene expression journal Nature volume 414 issue 6863 pages 550 4 year 2001 month Dec pmid 11734856 pmc doi 10.1038 35107085 ref ref name entrez The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The protein encoded by this gene is the alpha 3 subunit of one of several alpha beta subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension hypoxia . The alpha 3 subunit lacks the transactivation domain found in factors containing either the alpha ... of hypoxia inducible gene expression. At least three transcript variants encoding three different isoforms have been found for this gene. ref name entrez cite web title Entrez Gene HIF3A hypoxia ... 64344 accessdate ref See also Hypoxia inducible factors References reflist Further ... Molecular characterization and chromosomal localization of a third alpha class hypoxia inducible factor ... PAS domain protein IPAS is a hypoxia inducible splicing variant of the hypoxia inducible factor 3alpha ... of hypoxia inducible factor 1 by the inhibitory PAS proteins. journal Biochem. Biophys. Res. Commun ... 1356129 cite journal author Li QF, Wang XR, Yang YW, Lin H title Hypoxia upregulates hypoxia inducible ... more details
A radiosensitizer is a drug that makes tumor cells more sensitive to radiation therapy . One of the major limitations of radiotherapy is that the cells of solid tumors become deficient in oxygen. Solid tumors can outgrow their blood supply, causing a low oxygen state known as Hypoxia medical hypoxia . Oxygen is a potent radiosensitizer, increasing the effectiveness of a given dose of radiation by forming DNA damaging free radicals. Tumor cells in a hypoxic environment may be as much as 2 to 3 times more resistant to radiation damage than those in a normal oxygen environment. ref Cite journal author Harrison LB, Chadha M, Hill RJ, Hu K, Shasha D title Impact of tumor hypoxia and anemia on radiation therapy outcomes journal Oncologist volume 7 issue 6 pages 492 508 year 2002 pmid 12490737 doi 10.1634 theoncologist.7 6 492 url http theoncologist.alphamedpress.org cgi pmidlookup?view long&pmid 12490737 ref Much research has been devoted to overcoming this problem including the use of high pressure oxygen tanks, blood substitutes that carry increased oxygen, hypoxic cell radiosensitizers such as misonidazole and metronidazole , and hypoxic cytotoxins, such as tirapazamine . References Reflist NCI cancer dict External links http www.cancer.gov Templates db alpha.aspx?CdrID 46553 Radiosensitizer entry in the public domain NCI Dictionary of Cancer Terms Category Tumor markers antineoplastic drug stub Oncology stub de Radiosensitizer ... more details
HIF prolyl hydroxylase inhibitors are members of a class of new drugs that act on the hypoxia inducible factor HIF pathway. They are being investigated for treatment of anemia , chronic kidney disease ref http www.fasebj.org cgi content full 17 9 1186 Activation of the hypoxia inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors 2003 ref , cancer ref http www.maedica.ro articole nr2 10 HIF PROLYL.pdf HIF PROLYL hydroxylase inhibitors From basic science to clinical trials 2006 ref , and for their effects on heart tissue ref http atvb.ahajournals.org cgi content abstract 27 12 2548 A Novel Class of Prolyl Hydroxylase Inhibitors Induces Angiogenesis and Exerts Organ Protection Against Ischemia 2007 ref and others. ref http www.drugs.com clinical trials fibrogen reports new research development hif prolyl hydroxylase inhibitors related endothelial 3230.html FibroGen Reports New Research on Development of HIF Prolyl Hydroxylase Inhibitors Related to Endothelial Progenitor Cells, Anti Inflammation, Cytoprotection and Erythropoiesis 2008 ref References reflist See also Hypoxia inducible factors As a therapeutic target DEFAULTSORT Hif Prolyl Hydroxylase Inhibitor Category Drugs pharma stub ... more details
IH has the following meanings In Medicine Immune histochemistry intrauterine hypoxia Hepatitis A infectious hepatitis Inhibiting hormone Other Induction heating Induction heater Induction cooker Interstate Highway International Harvester Imogen Heap International House World Organisation disambig Category Initialisms de IH fr IH ko IH it IH sw IH ja IH fi Ih ... more details
HIF can refer to The ISO 639 3 language code for Fiji Hindi High Intensity Fluorescent lamp Fluorescent lighting fixture Horizontal Integration Facility Hypoxia inducible factor a transcription factor that helps regulate cellular response to oxygen levels. Health Impact Fund a proposal of incentives for global health Football clubs Hammarby IF Helsingborgs IF Hvidovre IF disambig da HIF de HIF eo HIF fr HIF it HIF sv HIF ... more details
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