inline date April 2010 Humanmitochondrialgenetics is the study of the genetics of the DNA contained in human mitochondria . Mitochondria are small structures in cells that generate energy for the cell to use, and are hence referred to as the powerhouses of the cell. Mitochondrial DNA mtDNA is not transmitted through nuclear DNA nDNA . In humans, as in most multicellular organisms, mitochondrial DNA is inherited only from the mother s ovum . ref see Paternal mtDNA transmission ref Mitochondrial .... Review. Category Humanmitochondrialgenetics hu Mitokondri lis genetika vi B gen c a ti th ... of the 9 genes on the light strand code for mitochondrial tRNA molecules. Human mtDNA consists of 16,569 ... the origins of replication of both heavy and light strands. The entire humanmitochondrial DNA ... as that particular cell needs at the time. Humanmitochondrial DNA mtDNA has three Promoter biology ... . See also Paternal mtDNA transmission Humanmitochondrial DNA haplogroups Cambridge Reference Sequence Humanmitochondrial molecular clock Genetic genealogy DNA databases Genetic genealogy for lists ..., Roberts, Pearsall, Nester. Microbiology, A Human Perspective. Boston McGraw Hill Inc 2004. Mitochondrial ... of mitochondrial DNA genetic code codes for functional mitochondrial proteins, and therefore most mitochondrial ... disorders. Mitochondrial function and genome Because they provide 36 molecules of ATP per glucose ... to all higher organisms for sustaining life. The mitochondrial disease s are genetic disorder s carried in mitochondrial DNA, or nuclear DNA coding for mitochondrial components. Slight problems with any ... is very difficult 10 protons to enter the mitochondrial matrix along their concentration gradients ... lead to a number of diseases. Genome see Mitochondrial DNA Mitochondrial DNA mtDNA is present in mitochondria ... about 13 of them are coded on the mitochondrial DNA. Most of the 3000 proteins are involved in a variety ... copies of the mitochondrial genome are carried by each mitochondrion 2 10 in humans , mitochondrial ... more details
. Image Migration map4.png thumb right 350px Another model of human migration based on Mitochondrial DNA In humangenetics , a humanmitochondrial DNA haplogroup is a haplogroup defined by differences in Humanmitochondrialgeneticshumanmitochondrial DNA . Haplogroups are used to represent the major branch points on the mitochondrial phylogenetic tree. Understanding the evolutionary path of the female ... van Oven M, Kayser M title Updated comprehensive phylogenetic tree of global humanmitochondrial DNA variation journal Human Mutation volume 30 issue 2 pages E386 94 year 2009 month February pmid 18853457 doi 10.1002 humu.20921 ref and subsequent published research. Macro haplogroup L mtDNA L Mitochondrial ... founder and subsequent maternal gene flow in Indian population groups journal Journal of HumanGenetics ... DEFAULTSORT HumanMitochondrial Dna Haplogroup Category Human mtDNA haplogroups ar ...Image Map of human migrations.jpg 340px right thumb Hypothesized world map of human migrations, with the North ... America at the far right. Migration patterns are based on studies of mitochondrial matrilinear DNA ... back to human origins in Africa and the subsequent spread across the globe. The letter names of the haplogroups ... humans . She is commonly called Mitochondrial Eve . genetic genealogy Evolutionary relationship ... of Eve Bryan Sykes had claimed there were seven major mitochondrial lineages for modern Europeans ... DNA test Genetic Genealogy MtDna haplogroups by populations Human Y chromosome DNA haplogroups GeneticsHumanmitochondrial molecular clock Cambridge Reference Sequence haplogroup Humanmitochondrialgenetics Hypervariable region Molecular phylogeny Population Genetics Bio Informatics References references External links Mitochondrial Phylogenetic Trees Ian Logan s http www.ianlogan.co.uk mtDNA.htm Mitochondrial DNA Site Mannis van Oven s http www.phylotree.org PhyloTree.org http www.stats.gla.ac.uk vincent images skeleton07 08 02.jpg Mitochondrial haplogroup skeleton Vincent Macaulay s http ... more details
Human mtDNA haplogroups Category Phylogenetics Category Humanmitochondrialgenetics Category Prehistoric ...The humanmitochondrial molecular clock is the rate at which mutations have been accumulating in the mitochondrial ... of the mutation rate of humanmitochondrial DNA mtDNA vary greatly depending on the available ... year 2003 title The Pedigree Rate of Sequence Divergence in the HumanMitochondrial Genome There Is a Difference ... first6 C volume 72 issue 3 pages 659 70 doi 10.1086 368264 journal American journal of humangenetics ... of human mtDNA as 7990 years per synonymous mutation over the mitochondrial genome. ref name loogvali2009 ... . These two errors would result in an overestimate of the humanmitochondrial TMRCA. However, they failed ... sequences of contemporary human populations will generally differ from Mitochondrial Eve s sequence ... in the control region of humanmitochondrial DNA author Santos C, Sierra B, Alvarez L, Ramos ... first3 AJ title Bayesian coalescent inference of major humanmitochondrial DNA haplogroup expansions ... Manica first5 A title Climate shaped the worldwide distribution of humanmitochondrial DNA sequence ... journal American Journal of HumanGenetics volume 82 issue 5 pages 1130 40 year 2008 month May pmid ... first2 M last3 Wilson first3 AC title Mitochondrial DNA and human evolution journal Nature volume ... last1 Endicott first1 P last2 Ho first2 SY title A Bayesian evaluation of humanmitochondrial ... Dependency of HumanMitochondrial DNA Mutation Rate Estimates year 2009 last1 Henn last2 Gignoux last3 ... substitution rate in the humanmitochondrial DNA control region journal Nat. Genet. volume 15 issue ... 609 journal American journal of humangenetics doi 10.1086 302902 Citation last1 Soares first1 P ... selection an improved humanmitochondrial molecular clock journal American Journal of Human ... African populations and the evolution of humanmitochondrial DNA journal Science volume 253 issue 5027 ... HJ title Mitochondrial footprints of human expansions in Africa journal Am. J. Hum. Genet. volume ... more details
saved book title HumanGenetics subtitle cover image cover color Humangenetics Intro to Genetics Introduction to genetics Cell Structure and Function Molecular Genetics Mendelian Inheritance Mendelian inheritance Beyond Mendel Non Mendelian inheritance Epistasis Epigenetics Pedigrees Inheritance Patterns Development Category Wikipedia books on biology HumanGenetics Category Wikipedia books on health HumanGenetics ... more details
The International Congress of HumanGenetics is the foremost meeting of the international humangenetics community. The first Congress was held in 1956 in Copenhagen , and has met every five years since then. The Congress is held under the auspices of the International Federation of HumanGenetics Societies, http mail.medacad.org www.ichg2001.org an umbrella organization founded by the American Society of HumanGenetics, the European Society of HumanGenetics and HumanGenetics Society of Australasia. Congresses have been held in such diverse venues as Berlin , Brisbane , Chicago , The Hague , Jerusalem , Mexico City , Paris , Rio de Janeiro , Vienna and Washington, D.C. Washington . The purview of the International Congress of HumanGenetics is all aspects of humangenetics, including research, clinical practice, and education. The Congress now attracts thousands of participants, including Doctor of Medicine M.D. medical geneticists, Ph.D. human geneticists and genetic counselor s from 80 or more countries. It is by far the largest humangenetics meeting in the world. External links http www.ichg2011.org 12th International Congress of HumanGenetics, 2011, Montreal, Canada DEFAULTSORT International Congress Of HumanGenetics Category Genetics organizations Category Recurring events established in 1956 genetics stub ... more details
refimprove date July 2009 Infobox journal title HumanGenetics cover editor David N. Cooper , Thomas J. Hudson discipline Humangenetics language English abbreviation Hum. Genet. formernames Humangenetik publisher Springer Science Business Media country frequency Biweekly history 1964 present openaccess license impact 5.047 impact year 2010 website http www.springer.com biomed humangenetics journal 439 link1 http www.springerlink.com content 100421 link1 name Online access link2 link2 name JSTOR OCLC 2699217 LCCN CODEN ISSN 0340 6717 eISSN 1432 1203 HumanGenetics is a Peer review peer reviewed medical journal covering all aspects of humangenetics , including legal and social issues. ref cite web url http www.springer.com biomed humangenetics journal 439 title About this journal publisher Springer Science Business Media work HumanGenetics accessdate 2011 08 13 ref References Reflist External links Official http www.springer.com biomed humangenetics journal 439 Category Medical genetics journals med journal stub ... more details
Italic title Infobox journal title American Journal of HumanGenetics cover editor Cynthia C. Morton discipline Medical genetics abbreviation Am. J. Hum. Gen. publisher Cell Press country frequency Monthly history 1948 present openaccess license impact 12.303 impact year 2009 website http www.cell.com AJHG home link1 link1 name link2 link2 name JSTOR OCLC 1480145 LCCN CODEN ISSN 0002 9297 eISSN The American Journal of HumanGenetics is a medical journal in the field of humangenetics . Since its inception in 1948 by the American Society of HumanGenetics , the journal has provided a record of research and review relating to heredity in human s and to the application of Genetics genetic principles in medicine and public policy , as well as in related areas of molecular biology molecular and cell biology . ref http www.eurekalert.org pub releases 2007 06 cp cpa061107.php Cell Press announces new partnership with the American Society of HumanGenetics Eurekalert ref Topics covered by The American Journal of HumanGenetics include behavioural genetics behavioral genetics molecular biology biochemical genetics medical genetics clinical genetics cytogenetics study of chromosome s teratology dysmorphology study of congenital disorder congenital malformations gene therapy genetic counseling genetic epidemiology genomics immunogenetics combination of immunology and genetics molecular genetics neurogenetics combination of neuroscience and genetics population genetics See also American Journal of Medical Genetics References refs Category Cell Press academic journals Category Medical genetics journals Category Monthly journals Category Publications established in 1948 Category English language journals ... more details
italictitle Infobox Journal title Journal of HumanGenetics cover File JHumGenetCover.jpg editor Katsushi Tokunaga discipline Genetics language English language English abbreviation J. Hum. Genet. publisher Nature Publishing Group country England frequency 12 year history 1956 openaccess impact 2.431 impact year 2008 website http www.nature.com jhg index.html link1 link1 name link2 link2 name RSS atom JSTOR OCLC LCCN CODEN ISSN 1434 5161 eISSN 1435 232X The Journal of HumanGenetics has been published by the Nature Publishing Group since January 2009, on behalf of the Japan Society of HumanGenetics . ref http www.nature.com jhg index.html Nature s HumanGenetics Journal description page ref Prior to this, it had been called the Japanese Journal of HumanGenetics and was independently published by the JSHG, before Springer Verlag took over publishing in 1998. ref http jshg.jp e introduction index.html JSHG History Web Page ref While under Springer the journal changed from a bimonthly to a monthly periodical. The Journal of HumanGenetics focuses on medical genetics and human genome analysis. It had a 2008 impact factor of 2.431. ref http www.springerlink.com content 101565 Springer s Journal of HumanGenetics description page ref References references Sci journal stub Category Genetics journals Category Nature Publishing Group academic journals Category Springer academic journals Category Publications established in 1956 ... more details
Infobox journal title European Journal of HumanGenetics cover Image Ejhg.jpg 150px editor Gert Jan B van Ommen discipline Humangenetics peer reviewed language English language English abbreviation Euro. J. Hum. Genet., EJHG publisher Nature Publishing Group country United Kingdom frequency 12 year history openaccess license impact 4.380 impact year 2010 website http www.nature.com ejhg link1 link1 name link2 link2 name RSS atom JSTOR OCLC LCCN CODEN ISSN 1018 4813 eISSN 1476 5438 boxwidth The European Journal of HumanGenetics EJHG is the official journal of the European Society of HumanGenetics . It focuses on humangenetics , and is published monthly by the Nature Publishing Group . ref http www.nature.com press releases ejhg.html Open access option now available on European Journal of HumanGenetics Nature ref In 2010 its impact factor was 4.380, ranking it 30th out of 156 Journals in the category Genetics & Heredity . Key areas EJHG covers many areas in the humangenetics field ref http gort.ucsd.edu newjour e msg02464.html gort.ucsd.edu newjour e msg02464.html ref Congenital disorder Cancer Heredity Hereditary cancer Monogenic disorder Gene mapping Genetic variation genome ref http www.nature.com ejhg journal v17 n8 full ejhg200932a.html Personal genomics EJHG ref Animal model s References reflist External links http www.nature.com ejhg European Journal of HumanGenetics website http www.time.com time health article 0,8599,1951968 4,00.html Why Your DNA Isn t Your Destiny TIME http www.washingtonpost.com wp dyn content article 2009 01 28 AR2009012801749.html Gene Discovered for Most Common Form of Epilepsy The Washington Post http www.genomeweb.com european genetics group offers genetic testing patent recommendations European Genetics Group Offers Genetic Testing Patent Recommendations GenomeWeb Georg von Holtzbrinck Publishing Group Category Genetics journals ... European Journal of HumanGenetics ... more details
Human evolutionary genetics studies how one human genome differs from the other, the evolutionary past ... mitochondrial DNA or Y chromosomal Adam Y chromosome sequences are used to study ancient human demographics. These single Locus genetics locus sources of DNA do not genetic recombination recombine and are almost ..., Allan C. Wilson 1987 http artsci.wustl.edu landc html cann Mitochondrial DNA and human evolution ... source of the humanmitochondrial gene pool. This inference comes from the observation that one of the two ... Hurles, Matthew. Human Evolutionary Genetics. Origins, Peoples and Disease. ISBN 0 8153 4185 7 Yunis ... Human Evolution Humangenetics DEFAULTSORT Human Evolutionary Genetics Category Humangenetics Category ... and forensic implications and applications. Genetic data can provide important insight into human ... Biologists classify human s, along with only a few other species , as great ape s species ..., in turn, belong to the primate s order 400 species . Data from both mitochondrial DNA mtDNA and nuclear ... 1395351 ref Cladistics Image Human phylo tree.png thumb center 610px A phylogenetic tree like the one ... humans and chimps is less than 2 , ref http www.pbs.org wgbh evolution library 07 3 l 073 47.html Human ... of years. The mitochondrial most recent common ancestor of modern humans lived roughly 200,000 years ... note that only a very rough representation of human phylogeny is given . Note that vertical distances ..., humans and chimpanzees appear to be most closely related, but some point to a human gorilla or chimpanzee gorilla clade . The human genome has been sequenced, as well as the chimpanzee genome. Humans have 23 pairs of chromosomes, while chimpanzees, gorillas, and orangutans have 24. Chromosome 2 humanHuman chromosome 2 is a fusion between two chromosomes that remained separate in the other primates ... that an antigen from one species human albumin induces in the immune system of another species human, chimpanzee, gorilla and Old World monkey s . Closely related species should have similar antigens ... more details
The American Society of HumanGenetics ASHG , founded in 1948, is the primary professional membership organization for specialists in humangenetics worldwide. As of 2009, the organization had approximately 8,000 members. The Society s members include researchers, academicians, clinicians, laboratory practice professionals, genetic counselors, nurses, and others who have a special interest in the field of humangenetics. ref name ASHGhistory cite web url http www.ashg.org pages about history.shtml title History, American Society of HumanGenetics accessdate 2009 06 07 ref ASHG serves research scientists ... at the Society s Annual Meeting and in The American Journal of HumanGenetics AJHG Advance genetic research by advocating for research support Enhance genetics education by preparing future professionals ... policies. The ASHG Annual Meeting is the oldest and largest international humangenetics conference ..., and clinical humangenetics research and technology. The ASHG Meeting also offers exhibitors ... genetics research and data analysis. ASHG s principal publication is the American Journal of HumanGenetics AJHG . The Society s highest honor, awarded annually since 1961, is the William Allan ... and far reaching scientific contributions to humangenetics, performed over a sustained period ... 2009 06 07 ref br As the field of humangenetics has expanded, ASHG has founded additional organizations .... American Board of Medical Genetics , founded in 1981, to certify practitioners in humangenetics ... American Society of HumanGenetics http www.cell.com AJHG American Journal of HumanGenetics http www.ashg.org meetings meetings geninfo.shtml ASHG Annual Meeting Category Genetics organizations ... scientific achievements over the previous ten years. On January 2, 2008, the American Society of HumanGenetics released a statement on direct to consumer sales of genetic tests , calling for improved ... of Medical Genetics , founded in 1991, as a specialty board for medical geneticists at the doctoral ... more details
third party sources date February 2011 The HumanGenetics Commission is a non departmental public body body that advises the UK government on the ethical and social aspects of genetics . This includes genetic testing, cloning and other aspects of molecular medicine. The Commission is chaired by Professor Jonathan Montgomery and comprises 21 members whose backgrounds include the law, medicine, consumer affairs, philosophy and ethics, scientific research and clinical practice. Representatives of the Chief Medical Officers of England, Scotland, Wales and Northern Ireland also sit on the Commission. External links http www.hgc.gov.uk The HumanGenetics Commission home page genetics stub UK med org stub Category Health in the United Kingdom Category Non departmental public bodies of the United Kingdom government Category Department of Health United Kingdom Category Ethics commissions ... more details
Expert subject Biology date April 2009 Quantitative human behavioural genetics is a specialisation in the biology biological field of behaviour genetics that studies the role of genetics in human behaviour employing Quantitative genetics quantitative genetic methods. The field is an overlap of quantitative genetics and psychology . Classically, human behavioural geneticists have studied the Biological ... Galton History In 1869, Francis Galton published the first empirical work in human behavioural genetics .... Contemporary human behavioural quantitative genetics studies special populations such as Twin study ... genetics Currently, the largest branch of human behavioural genetics is psychiatric genetics ... in behaviour genetics have indicated an additional focus toward researching the inheritance of human ... the International Behavioral Neuroscience Society . Methods of human behavioural geneticsHuman behavioural ... HumanGenetics for the Social Sciences . Thousand Oaks , CA SAGE Publications Sage Publications . DeFries, J. C., McGuffin, P., McClearn, G. E., Robert Plomin Plomin, R. 2000 Behavioral Genetics 4th ... Human Genome elsi behavior.shtml US Human Genome Project on Behavioral Genetics Category ... indeed genetic influences on human behaviour. In psychology, this phase lasted for the first ... aggressive child characteristics is it the parenting or the genes? . Thus, behaviour genetics ... of genes. This branch of behaviour genetics research is becoming more closely associated with mainstream ..., including the International Behavioural and Neural Genetics Society , Behavior Genetics Association , the International Society for Psychiatric Genetics , and the International Society for Twin ... relationship human relationships which disentangle genetic and environmental relatedness. So, for instance ... genetic contributions equal across children with paternal genetics and family environments and the virtual ... as diverse as dental caries , Body mass index BMI , ageing , substance abuse , human sexuality sexuality ... more details
class infobox cellspacing 5 style width 22em text align left font size 88 line height 1.5em style font size larger MRC Human Genetics Unit colspan 2 style text align center Founded 1967 Location Edinburgh, UK Director Prof Nick Hastie FRS CBE br Website http www.hgu.mrc.ac.uk http www.hgu.mrc.ac.uk The Medical Research Council UK Human Genetics Unit is situated at the Western General Hospital in Edinburgh . It is one of the largest MRC research establishments, housing over two hundred scientists, support staff, research fellows, PhD students, and visiting workers. Directors 1956 1969 Dr Michael Court Brown 1969 1994 Professor John Evans 1994 Present Professor Nick Hastie Sections The Human Genetics Unit is divided into four sections. Three are research sections and the fourth provides administrative, computing and technical services for the Unit as a whole. Medical and Developmental Genetics Section Heads Professor Veronica Van Heyningen Veronica van Heyningen , Professor Ian Jackson Chromosome and Gene Expression Section Head Professor Wendy Bickmore Biomedical Systems Analysis Section Head Professor Richard Baldock Administration, Computing and Technical Services Head Dr Kate Wilson Institute of Genetics and Molecular Medicine IGGM The Human Genetics Unit recently formed a partnership with two neighbouring research centres on the Western General Hospital campus, the http www.mmc.med.ed.ac.uk Centre for Molecular Medicine University of Edinburgh and the http www.ecrc.ed.ac.uk Edinburgh Cancer Research Centre Cancer Research UK , to form the http www.igmm.ac.uk Institute of Genetics and Molecular Medicine . External links http www.mrc.ac.uk Medical Research Council UK http www.hgu.mrc.ac.uk MRC Human Genetics Unit http www.igmm.ac.uk Institute of Genetics and Molecular Medicine http www.mmc.med.ed.ac.uk Centre for Molecular Medicine http www.ecrc.ed.ac.uk Edinburgh Cancer Research Centre http www.nhslothian.scot.nhs.uk hospitals wgh.asp Western General Hospital Cate ... more details
Infobox Journal cover File Indian Journal of Human Genetics.gif discipline Humangenetics website http www.ijhg.com publisher Medknow Publications country India frequency Triannual abbreviation Indian J. Hum. Genet. history 1995 present ISSN 0971 6866 eISSN 1998 362X LCCN 2003252107 OCLC 52961585 The Indian Journal of HumanGenetics is a Peer review peer reviewed Open access publishing open access medical journal published on behalf of the Indian Society of HumanGenetics . The journal publishes articles on humangenetics , including gene structure, genome variation, population genetics , molecular genetics , statistical genetics, Mendelian disorders, pharmacogenetics , cytogenetics , developmental biology developmental genetics , and genetic epidemiology . Abstracting and indexing The journal is indexed in Abstracts on Hygiene and Communicable Diseases, BIOBASE, Bioline International, CAB Abstracts, Caspur, Chemical Abstracts, CINAHL, CSA databases, Current Contents Life Sciences, DOAJ , EBSCO , EMBIOLOGY, Excerpta Medica EMBASE , Expanded Academic ASAP, JournalSeek , Global Health, Google Scholar , Health & Wellness Research Center, Health Reference Center Academic, HINARI , Index Copernicus, IndMed, Journal Citation Reports , OpenJGate, PubMed , Science Citation Index Expanded , Scimago Journal Ranking, SCOLOAR, Scopus , SIIC databases, Tropical Diseases Bulletin, and Ulrich s Periodicals Directory . External links Official http www.ijhg.com Category Open access journals Category English language journals Category triannual journals Category genetics journals Category Medknow Publications academic journals Category Publications established in 1995 ... more details
Infobox Journal title Annals of HumanGenetics cover Image Cover Annals of HumanGenetics 2005.jpg discipline Genetics , Human biology language English abbreviation Ann. Hum. Genet. link1 http www.blackwellpublishing.com journal.asp?ref 0003 4800&site 1 link1 name Content URL link2 http www.blackwellpublishing.com aims.asp?ref 0003 4800 link2 name Informational URL publisher Blackwell Publishing country United Kingdom UK history 1925 to 1954 as Annals of Eugenics br 1954 to 2002 under present title by Cambridge University Press br 2003 to present under present title by present publisher ISSN 1469 1809 The Annals of HumanGenetics , formerly known as the Annals of Eugenics is a scientific journal concerning humangenetics . The Annals of Eugenics was established in 1925 by Karl Pearson , who earlier in 1901 had established Biometrika . The name was changed in 1954 ref doi 10.1016 S0140 6736 04 16280 6 ref to reflect changing views on the role of eugenics in society. This journal was included by the Institute for Scientific Information as one of the 262 journals published between 1900 1944 ... identified as providing the most relevant significant and useful information of that era to today s researcher . It appears among the over 14,000 scientific journals listed by the Institute for Scientific Information , so it meets the standards for listing of that organization. ref http scientific.thomson.com cgi bin jrnlst jlresults.cgi?PC HI Journal Search Thomson Scientific Bot generated title ref Footnotes See http en.wikipedia.org wiki Wikipedia Footnotes for an explanation of how to generate footnotes using the ref and ref tags and the tag below references External links http www.blackwellpublishing.com journal.asp?ref 0003 4800 Blackwell site http www.gene.ucl.ac.uk anhumgen Official site biology journal stub Category Genetics journals Category Wiley Blackwell academic journals pt Annals of HumanGenetics ... more details
Italic title mediawiki Infobox journal cover image Twin Research and HumanGenetics cover.jpg editor Nick Martin discipline Genetics abbreviation Twin Res. Hum. Genet. formernames Twin Research publisher Australian Academic Press country Australia frequency Bimonthly history 1998 present openaccess After 12 months impact 1.994 impact year 2009 website http www.australianacademicpress.com.au journals details 9 Twin Research and HumanGenetics link1 http www.atypon link.com AAP loi twin link1 name Online access OCLC 58840748 LCCN 2005243379 CODEN ISSN 1832 4274 eISSN Portal Neuroscience Twin Research and HumanGenetics is a Peer review peer reviewed scientific journal published bimonthly by the Australian Academic Press . It is the official journal of the International Society for Twin Studies ISTS . The journal covers research on the biology and epidemiology of twin ning as well as biomedical and behavioral twin and molecular genetic research. According to the Journal Citation Reports , it has a 2009 impact factor of 1.994. ref name WoS cite web url http isiwebofknowledge.com title Web of Science year 2011 accessdate 2011 04 06 ref The journal was established in 1998 and has been Editor in chief edited by Robert Derom 1998 1999 , and Nick Martin 2000 present . The title is a translation of Acta Geneticae Medicae et Gemellologiae , the original title of the first journal of the ISTS. References Reflist External links Official http www.australianacademicpress.com.au journals details 9 Twin Research and HumanGenetics DEFAULTSORT Twin Research And HumanGenetics Journal Category Genetics journals Category Neuroscience journals Category Psychology journals Category Psychiatry journals Category English language journals Category Publications established in 1998 Category Delayed open access journals Category Bimonthly journals Category Twin studies sci journal stub ... more details
Infobox journal title Human Molecular Genetics cover File Human Molecular Genetics.gif editor Kay Davies, Anthony Wynshaw Boris, and Joel Hirschhorn discipline Molecular genetics peer reviewed language English language English abbreviation Hum. Mol. Gen., Hum. mol. genet., HMG publisher Oxford University Press country Great Britain frequency 24 year history 1992 to present openaccess some license impact 7.386 impact year 200p website http hmg.oxfordjournals.org link1 http hmg.oxfordjournals.org cgi search?pubdate year &firstpage &DOI &author1 &author2 &title &andorexacttitle and&titleabstract &andorexacttitleabs phrase&fulltext Open Access article distributed under&andorexactfulltext phrase&fmonth Jan&fyear 2005&ttyear 2010&fdatedef 1 January 1985&tdatedef 31 December 2010&flag &RESULTFORMAT 1&hits 10&hitsbrief 25&sortspec date&sortspecbrief relevance&sendit Search link1 name Open access articles link2 link2 name RSS atom JSTOR OCLC 39511714 LCCN 92643389 CODEN ISSN 0964 6906 eISSN 1460 2083 boxwidth Human Molecular Genetics , first published in 1992, is a semimonthly peer reviewed , scientific journal , published by The Oxford University Press . The journal s focus is research papers on all topics related to Geneticshuman molecular genetics . In addition, two special review issues are published each year. There are three professors who share the title of Executive Editor for this journal Professor Kay Davies from the University of Oxford , Professor Anthony Wynshaw Boris from the University of California in San Francisco, and Professor Joel Hirschhorn from Harvard Medical School . ref name home http hmg.oxfordjournals.org Home page. Oxford Journals. July 2010. ref This journal ... LCCN http lccn.loc.gov 92643389 Human molecular genetics . Library of Congress. 2010. ref Impact ... About the journal . Oxford Journals. July 2010 ref Indexing Human Molecular Genetics is indexed ... and Calcified Tissue Abstracts Chemical Abstracts Current Contents Life Sciences EMBASE Genetics ... more details
The Wellcome Trust Centre for HumanGenetics is a humangenetics research centre at the University of Oxford , funded by the Wellcome Trust among others. The centre at the Henry Wellcome Building of Genomic Medicine cost 20 million and was officially opened in June 2000 with Anthony Monaco as the director. ref cite news url http www.timeshighereducation.co.uk story.asp?storyCode 152220§ioncode 26 title Vanguard digs deep into data at Oxford last Farrar first Steve date 23 June 2000 work Times Higher Education accessdate 19 December 2011 ref References reflist External links official http www.well.ox.ac.uk Wellcome Trust coord 51.752248 N 1.215255 E display title genetics stub Category 1994 establishments in England Category Departments of the University of Oxford Category Genetics or genomics research institutions Category Research institutes in Oxford Category Wellcome Trust Category Educational institutions established in 1994 ... more details
Mitochondrial biogenesis is the process by which new mitochondria are formed in the cell. Mitochondrial biogenesis is activated by numerous different signals during times of cellular stress or in response to environmental stimuli. The mitochondrion is a key regulator of the metabolic activity of the cell, and is also an important organelle in both production and degradation of free radicals. It is thought that higher mitochodrial copy number or higher mitochondrial mass is protective for the cell. Mitochondria are produced from the transcription and translation of genes both in the nuclear genome and in the Mitochondrial DNA mitochondrial genome . The majority of mitochondrial protein comes from the nuclear genome, while the mitochondrial genome encodes most parts of the electron transport chain along with mitochondrial rRNA and tRNA . A major adaptation to mitochondrial biogenesis results in more mitochondrial tissues which increases metabolic enzymes for glycolysis, oxidative phosphorylation and ultimately a greater mitochondrial metabolic capacity. Peter D. Wagner Summer 2011 Lecture cn date October 2011 The master regulators of mitochondrial biogenesis appear to be the peroxisome proliferator activated receptor gamma PGC family of transcriptional coactivators, including PPARGC1A PGC 1 , PPARGC1B PGC 1 , and the PGC related coactivator, PRC. PGC 1 , in particular, is thought to be a master regulator. It is known to co activate nuclear respiratory factor 2 GABPA NRF2 GABPA , and together with NRF 2 coactivates nuclear respiratory factor 1 NRF1 . The NRFs, in turn, activate the mitochondrial transcription factor A TFAM tfam , which is directly responsible for transcribing nuclear encoded mitochondrial proteins. This includes both structural mitochondrial proteins as well as those involved in Humanmitochondrialgenetics Replication.2C repair.2C transcription.2C and translation mtDNA transcription, translation, and repair . See also mitochondria References Unreferenced ... more details
for more detailed inheritance patterns, see Humanmitochondrialgenetics . Mitochondrial disease ... ATP that powers most cell functions. Mitochondrial diseases are often caused by genetics or mutations to the mitochondrial DNA that affect mitochondria function. Mitochondrial diseases take on unique ... DNA . Humanmitochondrial DNA encodes only 13 proteins of the respiratory chain , while most ... successfully transplanted healthy DNA in human eggs from women with mitochondrial disease ... in human embryos to prevent transmission of mitochondrial DNA disease journal Nature volume 465 issue ...Unreferenced section date December 2011 Infobox Disease Name Mitochondrial disease Image Ragged red fibres gtc very high mag.jpg Caption Micrograph showing ragged red fibres, a finding seen in mitochondrial ... Mitochondrial diseases are a group of disorders caused by dysfunctional mitochondria , the organelle s that generate energy for the cell. Mitochondria are found in every cell of the human body except ... symptoms are often called a mitochondrial myopathy . Classification In addition to the mitochondrial ... age can be due to mitochondrial disease Diabetes mellitus and deafness can also be found together for other ... exercise intolerance MELAS Mitochondrial myopathy, encephalomyopathy, lactic acidosis, stroke like symptoms MELAS mtDNA depletion mitochondrial neurogastrointestinal encephalomyopathy MNGIE Nota bene Conditions such as Friedreich s ataxia can affect the mitochondria , but are not associated with mitochondrial ..., and dementia. Characteristics The effects of mitochondrial disease can be quite varied. Since the distribution of the defective mitochondrial DNA may vary from organ to organ within the body, and each ... severely, leading to multi system diseases. Mitochondrial diseases as a rule are worse when the defective ... author Finsterer J title Hematological manifestations of primary mitochondrial disorders journal ... because these cells use more energy than most other cells in the body. Although mitochondrial diseases ... more details
genetics populations ,such as through Genome Wide Association Studies. Given that genes are universal to living organisms, genetics can be applied to the study of all living systems, from virus es and bacteria , through plant s and domestic animals , to human s as in medical genetics . The fact ... books bv.fcgi?rid iga.section.229 chapter HumanGenetics editor first William M. ref These charts ...About the general scientific term the scientific journal Genetics journal pp move indef Genetics2 See introduction Genetics from Ancient Greek lang grc lang grc Latn genetikos , genitive and that from ... New York chapterurl http www.ncbi.nlm.nih.gov books bv.fcgi?rid iga.section.60 chapter Genetics and the Organism ... ref Genetics deals with the molecular Genetics molecular structure and function of genes, gene behavior in context of a cell biology cell or organism e.g. dominance genetics dominance and epigenetics ... crop plants and animals through selective breeding . However, the modern science of genetics ... 1 pages 1 25 discussion 26 journal American journal of medical genetics ref Although he did not know ... be inherited. The sequence of nucleotides in a gene is translation genetics translated by cells ... in the cell and on the organism as a whole. Although genetics plays a large role in the appearance and behavior of organisms, it is the combination of genetics with what an organism experiences that determines the ultimate outcome. For example, while genes play a role in determining an organism s human .... History Main History of genetics Image DNA Overview2.png thumb right 140px upright DNA , the molecular ... to form what look like rungs on a twisted ladder. Although the science of genetics began with the applied ... is now explained by the action of multiple genes with Quantitative genetics quantitative effects ... genetics Modern genetics started with Gregor Johann Mendel , a German Czech Augustinian monk and scientist .... William Bateson , a proponent of Mendel s work, coined the word genetics in 1905. ref genetics, n ... more details
humanmitochondrial molecular clock journal American Journal of HumanGenetics volume 84 issue ... 7867 1334 8 ref The Seven Daughters of Eve presents the theory of humanmitochondrialgenetics to a general ... Selection An Improved HumanMitochondrial Molecular Clock. and its http download.cell.com AJHG ... Humanmitochondrial DNA haplogroup Mitochondrial macro haplogroups Haplogroup L0 mtDNA L0 , Haplogroup L1 mtDNA L1 , and Haplogroup L5 mtDNA L5 mutations None In the field of humangenetics ... N, et al. title Correcting for purifying selection an improved humanmitochondrial molecular clock ... other human sub species. Mitochondrial Eve lived later than Homo heidelbergensis and the emergence ... first3 M last4 Stringer first4 C title Evaluating the mitochondrial timescale of human evolution ... and mitochondrial ancestry further2 Genetic genealogy matrilineal Mitochondrial DNA Humanmitochondrial ... line descended from mtDNA MRCA. File Mitochondrial eve tree.gif thumb right 250px Simplified Human ... of humanmitochondrial DNA journal PNAS volume 77 issue 11 pages 6715 6719 url http www.pnas.org ... contains all surviving humanmitochondrial lineages today, and she must predate the emergence of Haplogroup ... title Bayesian coalescent inference of major humanmitochondrial DNA haplogroup expansions in Africa ... Climate shaped the worldwide distribution of humanmitochondrial DNA sequence variation. journal ... Journal of HumanGenetics volume 82 issue 5 pages 1130 40 year 2008 month May pmid 18439549 pmc 2427203 ... Mitochondrial DNA and human evolution journal Nature volume 325 issue 6099 pages 31 6 year 1987 ... P last2 Ho first2 SY title A Bayesian evaluation of humanmitochondrial substitution rates journal ... first3 M last4 Stringer first4 C title Evaluating the mitochondrial timescale of human evolution ... first5 VM title Major genomic mitochondrial lineages delineate early human expansions journal ... M title Age of the common ancestor of humanmitochondrial DNA journal Mol. Biol. Evol. volume 9 ... more details
Humanmitochondrial DNA haplogroup HumanmitochondrialgeneticsMitochondrial disease Mitochondrial ...Image Mitochondrial DNA en.svg thumb 300px right Humanmitochondrial DNA. File Electron microscopy reveals mitochondrial DNA in discrete foci.jpg thumb Electron microscopy reveals mitochondrial DNA in discrete ... H, Cook PR title The functional organization of mitochondrial genomes in human cells journal BMC ... in this section is specific to humanmitochondrial DNA Electron transport chain The mitochondrial ... acids Mitochondrial DNA Use dmy dates date June 2011 Category DNA Category Mitochondrialgenetics ... marking mtDNA are found near the mitochondrial membrane. B Whole mount view of cytoplasm after ... www.biomedcentral.com 1741 7007 2 9 ref Mitochondrial DNA mtDNA or mDNA ref cite web last Sykes first B title Mitochondrial DNA and human history url http genome.wellcome.ac.uk doc WTD020876.html work The Human Genome publisher Wellcome Trust accessdate 5 February 2012 authorlink Bryan Sykes date 10 ... . Mitochondrial DNA can be regarded as the smallest chromosome , and was the first significant part of the human genome to be sequenced. In most species, including humans, mtDNA is inherited solely ... has become important in anthropology and field biology. Origin Nuclear and mitochondrial DNA are thought ... target molecules by exponential polymerase chain reaction, copy number of mitochondrial DNA in rat ... origin, having since been transferred to the eukaryotic nucleus during evolution . Mitochondrial ... injecting a sperm into an oocyte , may interfere with this. The fact that mitochondrial DNA ... region s HVR1 or HVR2 of the mitochondrial DNA, as with a genealogical DNA test . HVR1 consists ... issn 0036 8075 pmid 9180076 issue 5319 ref The concept of the Mitochondrial Eve is based on the same type of analysis, attempting to discover the origin of human ity by tracking the lineage ... limited biparental inheritance of Mytilus mitochondrial DNA journal Science volume 251 pages 1488 1490 ... more details
Mitochondrial toxicity is a condition in which the mitochondrion mitochondria of a body s cells become damaged or decline significantly in number it occurs as a side effect of certain antiretroviral drug s used to treat human immunodeficiency virus, or HIV . Causes While the exact causes of mitochondrial toxicity are not known, research has shown that a certain group of anti viral drugs used to treat HIV, specifically nucleoside analog reverse transcriptase inhibitor s NRTIs , interfere with an enzyme needed in the production of mitochondria. ref http www.thebody.com pinf mitochondrial.html ref Symptoms The disruption of cell function that accompanies the condition can cause both mild and severe problems in people suffering from mitochondrial toxicity. The most commonly observed symptom is muscle weakness, or myopathy . Others include peripheral neuropathy numbness in the fingers and toes and pancreatitis inflammation of the pancreas , with the most severe being lactic acidosis , in which a build up of lactic acid in the tissues of the body leads to loss of energy, organ failure, and eventually death. ref http www.projinf.org fs mito b.html ref References references External links Mitochondrial toxicity at http www.hivnet.org OverHivEnAids Alternatief BrochureBijwerkingenEngels Mitochondrial 20toxicity.htm hiv.org Category Toxicology medical stub med toxic stub sl Mitohondrijska toksi nost ... more details
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