GO code 0004415 image Hyaluronidase 1OJN.png width caption Infobox protein family Symbol Hyaluronidase 1 Name Hyaluronidase protein HylP image width caption the partial structure of a group a streptpcoccal ... PROSITE MEROPS SCOP TCDB OPM family OPM protein CAZy CDD Pfam box Symbol Hyaluronidase 2 Name Hyaluronidase ... . ref name pmid11731267 cite journal author Csoka AB, Frost GI, Stern R title The six hyaluronidase ... Use as a drug Drugbox Verifiedfields changed verifiedrevid 461771405 IUPAC name hyaluronidase image Clinical data tradename Drugs.com drugs.com CDI hyaluronidase pregnancy category C legal status routes ... of hyaluronan , a constituent of the interstitial dn date April 2012 barrier, hyaluronidase lowers ... in subcutaneous urography for improving resorption of radiodensity radiopaque agents. Hyaluronidase ... hyaluronidase include Hydase sup TM sup developed and manufactured by http www.primapharm.net PrimaPharm ... free animal derived hyaluronidase, Vitrase ISTA Pharmaceuticals , Amphadase Amphastar Pharmaceuticals ... a synthetic recombinant or rDNA human hyaluronidase, Hylenex Halozyme Therapeutics . ref name urlHalozyme ... of angiogenesis , although most hyaluronidase preparations are contaminated with large amounts ... doi 10.1002 ijc.10087 abstract ref As previously mentioned, there are six hyaluronidase genes ... cite journal author Starr CR, Engleberg NC title Role of hyaluronidase in subcutaneous spread ... journal author Zukaite V, Biziulevicius GA title Acceleration of hyaluronidase production in the course ... nlm pubmed&issn 0266 8254&date 2000&volume 30&issue 3&spage 203 ref produce hyaluronidase as a means ... pathogens use hyaluronidase as a virulence factor to destroy the polysaccharide that holds animal ... mammalian fertilization , hyaluronidase is released by the acrosome of the Spermatozoon sperm ... the ovum, it is able to penetrate this layer with the assistance of hyaluronidase enzymes present on the surface ... References reflist External links MeshName Hyaluronidase Glycoside hydrolases Category EC 3.2.1 de ... more details
Hyaluronidase deficiency also known as Mucopolysaccharidosis type IX is a condition caused by mutations in HYAL1 , and characterized by multiple soft tissue masses. ref name Andrews cite book author James, William D. Berger, Timothy G. et al. title Andrews Diseases of the Skin clinical Dermatology publisher Saunders Elsevier location year 2006 pages isbn 0 7216 2921 0 oclc doi accessdate ref rp 544 See also Morquio syndrome Hunter syndrome Hurler syndrome Skin lesion References reflist Cutaneous condition stub Category Skin conditions resulting from errors in metabolism ... more details
PBB geneid 3373 Hyaluronidase 1 is an enzyme that in humans is encoded by the HYAL1 gene . ref name pmid9223416 cite journal author Frost GI, Csoka AB, Wong T, Stern R title Purification, cloning, and expression of human plasma hyaluronidase journal Biochem Biophys Res Commun volume 236 issue 1 pages 10 5 year 1997 month Aug pmid 9223416 pmc doi 10.1006 bbrc.1997.6773 ref ref name pmid9409739 cite journal author Csoka AB, Frost GI, Wong T, Stern R title Purification and microsequencing of hyaluronidase isozymes from human urine journal FEBS Lett volume 417 issue 3 pages 307 10 year 1998 month Jan pmid 9409739 pmc doi 10.1016 S0014 5793 97 01309 4 ref ref name entrez cite web title Entrez Gene ... encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major ..., migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase ... See also Hyaluronidase deficiency References reflist Further reading refbegin 2 PBB Further reading ... Natowicz MR, Short MP, Wang Y, et al. title Clinical and biochemical manifestations of hyaluronidase ... 10.1056 NEJM199610033351405 cite journal author Cs ka AB, Frost GI, Heng HH, et al. title The hyaluronidase ... in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities .... title Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription ... VB, Schroeder GL, Carey RI, et al. title Regulation of hyaluronidase activity by alternative mRNA splicing ... EJ, Schroeder GL, Goodwin WJ, et al. title Expression of tumor markers hyaluronic acid and hyaluronidase ... Christopoulos TA, Papageorgakopoulou N, Theocharis DA, et al. title Hyaluronidase and CD44 hyaluronan ... hyaluronidase a negative regulator of bladder cancer. journal Cancer Res. volume 66 issue 23 pages ..., Spickenreither M, Oschmann J, et al. title Recombinant human hyaluronidase Hyal 1 insect cells versus ... more details
Infobox protein family Symbol Glyco hydro 56 Name Hyaluronidase image PDB 1fcv EBI.jpg width caption crystal structure of bee venom hyaluronidase in complex with hyaluronic acid tetramer Pfam PF01630 Pfam clan CL0058 InterPro IPR018155 SMART PROSITE MEROPS SCOP 1fcv TCDB OPM family 125 OPM protein 1fcq CAZy GH56 CDD In molecular biology, glycoside hydrolase family 56 is a Protein family family of Glycoside hydrolase glycoside hydrolases . Glycoside hydrolases EC number 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of 100 different families. ref name PUB00004870 cite journal author Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G title Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases journal Proc. Natl. Acad. Sci. U.S.A. volume 92 issue 15 pages 7090 7094 year 1995 pmid 7624375 doi 10.1073 pnas.92.15.7090 pmc 41477 ref ref name PUB00005266 cite journal author Henrissat B, Davies G title Structures and mechanisms of glycosyl hydrolases journal Structure volume 3 issue 9 pages 853 859 year 1995 pmid 8535779 doi 10.1016 S0969 2126 01 00220 9 ref ref http www.expasy.ch cgi bin lists?glycosid.txt Bairoch, A. Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS PROT . 1999. ref This classification is available on the CAZy http www.cazy.org GH1.html ... Family 56 CAZY GH 56 includes enzymes with hyaluronidase EC number 3.2.1.35 activity. The venom ... is a hyaluronidase. ref name PUB00004814 cite journal author Gmachl M, Kreil G title Bee venom hyaluronidase is homologous to a membrane protein of mammalian sperm journal Proc. Natl. Acad. Sci ... ref The amino acid sequence of bee venom hyaluronidase contains 349 amino acids, and includes four ... more details
Orphan date February 2009 PBB geneid 6677 Hyaluronidase PH 20 is an enzyme that in humans is encoded by the SPAM1 gene . ref name pmid8282124 cite journal author Gmachl M, Sagan S, Ketter S, Kreil G title The human sperm protein PH 20 has hyaluronidase activity journal FEBS Lett volume 336 issue 3 pages 545 8 year 1994 month Feb pmid 8282124 pmc doi 10.1016 0014 5793 93 80873 S ref ref name pmid8575780 cite journal author Jones MH, Davey PM, Aplin H, Affara NA title Expression analysis, genomic structure, and mapping to 7q31 of the human sperm adhesion molecule gene SPAM1 journal Genomics volume 29 issue 3 pages 796 800 year 1996 month Mar pmid 8575780 pmc doi 10.1006 geno.1995.9931 ref ref name entrez cite web title Entrez Gene SPAM1 sperm adhesion molecule 1 PH 20 hyaluronidase, zona pellucida binding url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 6677 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1 another family member on chromosome 3p21.3 has been assigned HYAL1. This gene ... protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic ... The six hyaluronidase like genes in the human and mouse genomes. journal Matrix Biol. volume 20 ... Cherr GN, Yudin AI, Overstreet JW title The dual functions of GPI anchored PH 20 hyaluronidase and intracellular ... journal author Lin Y, Mahan K, Lathrop WF, et al. title A hyaluronidase activity of the sperm plasma ... Cs ka AB, Scherer SW, Stern R title Expression analysis of six paralogous human hyaluronidase genes ... more details
PBB geneid 8372 Hyaluronidase 3 is an enzyme that in humans is encoded by the HYAL3 gene . ref name pmid10493834 cite journal author Csoka AB, Scherer SW, Stern R title Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31 journal Genomics volume 60 issue 3 pages 356 61 year 1999 month Nov pmid 10493834 pmc doi 10.1006 geno.1999.5876 ref ref name entrez cite web title Entrez Gene HYAL3 hyaluronoglucosaminidase 3 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 8372 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. ref name entrez References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Muzny DM title The DNA sequence, annotation and analysis of human chromosome 3 journal Nature volume 440 issue 7088 pages 1194 8 year 2006 pmid 16641997 doi 10.1038 nature04728 author separator , author2 Scherer SE author3 Kaul R display authors 3 last4 Wang first4 Jing last5 Yu first5 Jun last6 Sudbrak first6 Ralf last7 Buhay first7 Christian J. last8 Chen first8 Rui last9 Cree first9 Andrew ... journal author Lokeshwar VB title Regulation of hyaluronidase activity by alternative mRNA splicing ... hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream ... Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase ... more details
which cause damage to host tissues. Enzymes include hyaluronidase , which breaks down the connective ... while outside a host. Examples Examples of virulence factors for Staphylococcus aureus are hyaluronidase ... capsule, invasin s such as streptokinase , streptodornase , hyaluronidase , spenceronic , dorsettonic ... more details
Antonei B. Csoka, Ph.D. is a biogerontologist at the Roswell Park Cancer Institute who works on the molecular biology of aging . Research He was a member of the consortium that identified the Lamin A gene as the cause of the accelerated aging disease Hutchinson Gilford Progeria Syndrome. ref Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Recurrent de novo point mutations in lamin A cause Hutchinson Gilford progeria syndrome. Nature 2003 423 293 8. DOI 10.1038 nature01629 PMID 12714972. ref He also showed that atypical cases of Progeria can be caused by mutations in the same gene, ref Csoka AB, Cao H, Sammak PJ, Constantinescu D, Schatten GP, Hegele RA. Novel lamin A C gene LMNA mutations in atypical progeroid syndromes. J Med Genet. 2004 41 304 8 PMID 15060110. ref and currently researches the molecular etiology of these disorders. He showed that lamin A is a marker for human embryonic stem cell differentiation cellular differentiation , ref Constantinescu D, Gray HL, Sammak PJ, Schatten GP, Csoka AB. Lamin A C expression is a marker of mouse and human embryonic stem cell differentiation. Stem Cells 2006 24 177 85 DOI 10.1634 stemcells.2004 0159 PMID 16179429 ref which may have application in regenerative medicine , rejuvenation and cloning . In earlier work, he cloned the human hyaluronidase gene family. ref Csoka AB, Frost GI, Stern R. The six hyaluronidase like genes in the human and mouse genomes. Matrix Biology 2001 20 499 508. DOI 10.1016 S0945 053X 01 00172 X PMID 11731267. ref Life extension activities Dr. Csoka is a prominent proponent of life extension , cryonics and transhumanism . He is a scientific advisor to the Alcor Life Extension Foundation , and the Lifeboat Foundation, and was featured in the first Immortality Institute film, http www.imminst.org film Exploring Life Extension 2005 produced by Bruce Klein . See also Alcor ... more details
PBB geneid 8692 Hyaluronidase 2 is an enzyme that in humans is encoded by the HYAL2 gene . ref name pmid9712871 cite journal author Lepperdinger G, Strobl B, Kreil G title HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity journal J Biol Chem volume 273 issue 35 pages 22466 70 year 1998 month Sep pmid 9712871 pmc doi 10.1074 jbc.273.35.22466 ref ref name pmid9790770 cite journal author Strobl B, Wechselberger C, Beier DR, Lepperdinger G title Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase journal Genomics volume 53 issue 2 pages 214 9 year 1998 month Dec pmid 9790770 pmc doi 10.1006 geno.1998.5472 ref ref name entrez cite web title Entrez Gene HYAL2 hyaluronoglucosaminidase 2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 8692 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. Varying functions have been described for this protein. It has been described as a lysosomal hyaluronidase which is active at a pH below 4 and specifically ... protein which does not display hyaluronidase activity but does serve as a receptor for the oncogenic ... Sugano first5 S cite journal author Sun L title Expression profile of hyaluronidase mRNA transcripts ... in somatic tissues and body fluids. Evidence for conserved hyaluronidase potential N glycosylation ... A last5 Lerman first5 MI last6 Miller first6 AD cite journal author Delpech B title Hyaluronidase is more ... A title Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation ... more details
Use dmy dates date April 2012 Other people5 Ewen Cameron Ewan Cameron 31 July 1922, Dumbarton 21 March 1991 was a Scottish physician who worked with Linus Pauling on Vitamin C research. He received his medical degree from the University of Glasgow in 1944, and immediately joined the British Army , where he served as a medical officer in Burma for three years. Cameron was Consultant Surgeon at Vale of Leven Vale of Leven Hospital in the Dunbartonshire County of Dunbarton 1956 1982 , becoming the Senior Consultant Surgeon in 1973. He received the Queen s Silver Jubilee Medal in 1977, as well as fellowships from the Royal Colleges of Surgeons of Royal College of Surgeons of Glasgow Glasgow and Royal College of Surgeons of Edinburgh Edinburgh , and the Royal Faculty of Physicians and Surgeons in Glasgow . In 1966, Cameron published his first book, Hyaluronidase and Cancer . In 1971, Cameron began corresponding with Dr. Linus Pauling . He completed many scientific studies in conjunction with the institute, and published Cancer and Vitamin C with Pauling in 1979. After retirement from Vale of Leven Hospital in 1982, Cameron was invited to become Medical Director and Senior Research Professor at the Linus Pauling Institute , where he worked closely with Pauling on many research topics. External links http osulibrary.orst.edu specialcollections coll cameron index.html The Ewan Cameron Papers at Oregon State University Persondata Metadata see Wikipedia Persondata . NAME Cameron, Ewan ALTERNATIVE NAMES SHORT DESCRIPTION Scottish physician DATE OF BIRTH 31 July 1922 PLACE OF BIRTH Dumbarton DATE OF DEATH 21 March 1991 PLACE OF DEATH DEFAULTSORT Cameron, Ewan Category 1922 births Category 1991 deaths Category People from Dumbarton Category Scottish scientists Category Scottish surgeons Category Scottish medical doctors Category Alumni of the University of Glasgow Category Scottish soldiers Category Royal Army Medical Corps officers Scotland med bio stub pt Ewan Cameron ... more details
Ista may refer to Kevyn Ista born 1984 , Belgian road bicycle racer wikt ista ista , a pejorative suffix in English, regular suffix in Spanish, Portuguese, Italian, etc. Ista Bangladesh , a place in the Jessore District , Khulna Division of Bangladesh was listed at http en.wikipedia.org wiki Wikipedia WikiProject Missing encyclopedic articles Places bangladesh page15 Ista Hold, Ista Island, fictional locations in Anne McCaffrey s Dragonriders of Pern , see Holds of Pern the heroine of Paladin of Souls , a novel by Lois McMaster Bujold ISTA or Ista may also refer to International School of Theatre Anthropology since 1979 , based in the Odin Teatret, Denmark Internet Sacred Text Archive since 1999 , archive of cultural public domain texts International Seed Testing Association , co founded by the National Institute of Agricultural Botany Indiana State Teachers Association , in Indiana International Safe Transit Association , a company of cushioning http www.ista.org International Schools Theatre Association , based in the United Kingdom UK http www.ista.co.uk , networked in schools such as The British School, New Delhi or Ko School International Society for Technology Assessment , related to Bryan Jennett , Fred Polak Ista Pharmaceuticals or ISTA Pharmaceuticals, related to Calvin A. Grant , Hyaluronidase International School of Traditional Aikido an Aikido organisation founded in France. More stuff that s currently not linkable to something relevant Intertank Structural Test Assembly Independent Software Testing Association Indian Scientific Translators Association Information, Science and Technology Agency In Situ Thermal Annealing Intelligence, Surveillance and Target Acquisition International Safe Transport Association International Security Tuition Association International Special Tooling Association International Steel Trade Association Interdisciplinary Institute of Science, Technology and Art International Shipping and Trading Association Institut sup rieur ... more details
proteins. Hyaluronidase It is widely assumed hyaluronidase facilitates the spread of the bacteria through ..., very few isolates of S. pyogenes are capable of secreting active hyaluronidase due to mutations in the gene that encode the enzyme. Moreover, the few isolates that are capable of secreting hyaluronidase ... 2006 cite journal author Starr C, Engleberg N title Role of Hyaluronidase in Subcutaneous Spread and Growth ... doi 10.1128 IAI.74.1.40 48.2006 pmc 1346594 ref Thus, the true role of hyaluronidase in pathogenesis ... more details
The acrosome is an organelle that develops over the anterior half of the head in the Spermatozoon spermatozoa sperm cells of many animals. It is a cap like structure derived from the Golgi apparatus . Acrosome formation is completed during testicular maturation. In Eutheria n mammals the acrosome contains digestive enzyme s including hyaluronidase and acrosin . ref cite web url http encarta.msn.com encnet features dictionary DictionaryResults.aspx?refid 1861695331 title acrosome definition Dictionary MSN Encarta accessdate 2007 08 15 format work archiveurl http www.webcitation.org 5kwDPQanq archivedate 2009 10 31 deadurl yes ref These enzymes break down the outer membrane of the ovum , called the zona pellucida , allowing the haploid Cell nucleus nucleus in the sperm cell to join with the haploid nucleus in the ovum. This shedding of the acrosome or acrosome reaction can be stimulated in vitro by substances a sperm cell may encounter naturally such as progesterone or follicular fluid , as well as the more commonly used calcium ionophore A23187. This can be done to serve as a positive control when assessing the acrosome reaction of a sperm sample by flow cytometry ref Miyazaki et al. Archives of Andrology 25 243 251 1990 ref or Fluorescence microscope fluorescence microscopy . This is usually done after staining with a fluoresceinated lectin such as FITC PNA, FITC PSA, FITC ConA, or fluoresceinated antibody such as FITC CD46. ref Carver Ward et al. Journal of Assisted Reproduction and Genetics, Vol. 14, no. 2, 1997 ref Image Simplified spermatozoon diagram.svg thumb center 550px Human spermatozo n In the case of globozoospermia sperm with round heads , the Golgi apparatus is not transformed into the acrosome , causing male infertility . ref Page 155 in cite book author Hermann Behre Eberhard Nieschlag title Andrology Male Reproductive Health and Dysfunction publisher Springer location Berlin year 2000 pages isbn 3 540 67224 9 oclc doi accessdate ref References Reflis ... more details
Cleanup spam date March 2011 Restylane is the trade name for a range of injectable fillers with a specific formulation of non animal sourced hyaluronic acid HA . Restylane was the first stabilized hyaluronic acid filler on the market and reportedly has been used in over 11 million treatments worldwide 2010 . In the United States , Restylane was the first hyaluronic acid filler to be approved by the Food and Drug Administration United States U.S. Food and Drug Administration FDA for cosmetic injection into sub dermal facial tissues. ref http www.fda.gov cdrh MDA DOCS p020023.html FDA approval ref Restylane is produced by Q Med. Treatment areas Restylane is most commonly used for lip enhancement volume and contouring . It is used to diminish wrinkles and aging lines of the face such as the nasolabial fold s nose to mouth lines , melomental folds sad mouth corners , Wrinkles crow s feet and forehead wrinkles frown lines . It may also be used for filling aging related facial hollows and orbital troughs under and around the eyes , as well as for cheek volume and contouring of the chin, forehead and nose. Restylane can also be used to revitalize the skin by increasing skin elasticity structure, without the goal of adding volume, for example in the face, hands and d colletage. Duration and recovery time Duration depends on factors like the individual s skin type, lifestyle and age. After the initial treatment, follow up sessions are normally recommended around every 6 to 12 months depending on the individual and the treatment. A treatment of the lips lasts less than 6 months. Treatments have a recovery time of 2 to 3 days. Possible side effects and recovery A treatment with a dermal filler like Restylane can cause some temporary bruising in addition to swelling and numbness for a few days. In rare cases there has been reports of lumps or granulomas. These side effects can be easily reversed with a treatment of hyaluronidase , which is an enzyme that speeds up the natural d ... more details
enzyme Name hyaluronate lyase EC number 4.2.2.1 CAS number 37259 53 3 IUBMB EC number 4 2 2 1 GO code 0030340 image width caption In enzymology , a hyaluronate lyase EC number 4.2.2.1 is an enzyme that catalysis catalyzes the chemical reaction Cleaves hyaluronate chains at a beta D GalNAc 1 4 beta D GlcA bond, ultimately breaking the polysaccharide down to 3 4 deoxy beta D gluc 4 enuronosyl N acetyl D glucosamine This enzyme belongs to the family of lyase s, specifically those carbon oxygen lyases acting on polysaccharides. The systematic name of this enzyme class is hyaluronate lyase . Other names in common use include hyaluronidase but cf. internal xref ec num 3,2,1,35 , hyalurononglucosaminidase and internal xref ec num 3,2,1,36 , hyaluronoglucuronidase , glucuronoglycosaminoglycan lyase , spreading factor , and mucinase . Structural studies As of late 2007, 27 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1C82 , PDB link 1EGU , PDB link 1F1S , PDB link 1F9G , PDB link 1I8Q , PDB link 1LOH , PDB link 1LXK , PDB link 1LXM , PDB link 1N7N , PDB link 1N7O , PDB link 1N7P , PDB link 1N7Q , PDB link 1N7R , PDB link 1OJM , PDB link 1OJN , PDB link 1OJO , PDB link 1OJP , PDB link 1W3Y , PDB link 2BRP , PDB link 2BRV , PDB link 2BRW , PDB link 2C3F , PDB link 2DP5 , PDB link 2PK1 , PDB link 2YVV , PDB link 2YW0 , and PDB link 2YX2 . References reflist 1 cite journal author Linker A, Hoffman P, Meyer K, Sampson P and Korn ED date 1960 title The formation of unsaturated disacharides from mucopoly saccharides and their cleavage to alpha keto acid by bacterial enzymes journal J. Biol. Chem. volume 235 pages 3061 5 pmid 13762462 cite journal author MEYER K, RAPPORT MM date 1952 title Hyaluronidases journal Adv. Enzymol. Relat. Subj. Biochem. volume 13 pages 199&ndash 236 pmid 14943668 cite journal author Moran F, Nasuno S, Starr MP date 1968 title Extracellular and intracellular polygllacturonic a ... more details
chembox Verifiedfields changed verifiedrevid 404200034 Name Eckol ImageFile Eckol.PNG ImageSize 200px ImageName Chemical structure of eckol ImageAlt Chemical structure of eckol IUPACName 4 3,5 dihydroxyphenoxy dibenzo p dioxin 1,3,6,8 tetrol OtherNames br Section1 Chembox Identifiers CASNo 88798 74 7 CASNo Ref cascite correct ?? CASOther ChEMBL Ref ebicite changed EBI ChEMBL 471187 PubChem 145937 SMILES C1 C C C C C1O OC2 C C C C3 C2OC4 C C C C C4O3 O O O O O InChI MeSHName Section2 Chembox Properties Formula C sub 18 sub H sub 12 sub O sub 9 sub MolarMass 372.28 g mol ExactMass 372.048132 u Appearance Density MeltingPt C BoilingPt C Solubility Eckol is a phlorotannin isolated from brown algae Ecklonia species ref name Moon http onlinelibrary.wiley.com doi 10.1002 ptr.2298 abstract Protective effect of phlorotannin components phloroglucinol and eckol on radiation induced intestinal injury in mice. Changjong Moon, Sung Ho Kim, Jong Choon Kim, Jin Won Hyun, Nam Ho Lee, Jae Woo Park and Taekyun Shin, Phytotherapy Research, Volume 22, Issue 2, pages 238 242, February 2008 ref . The molecule possesses a dibenzo p dioxin skeleton and a phloroglucinol component. The molecule can also be viewed as a phloroglucinol trimer chemistry trimer ref Inhibitory activity of brown algal phlorotannins against hyaluronidase. Toshiyuki Shibata, Ken Fujimoto, Kohki Nagayama, Kuniko Yamaguchi and Takashi Nakamura, International Journal of Food Science & Technology, Volume 37, Issue 6, pp. 703 709, August 2002, doi 10.1046 j.1365 2621.2002.00603.x ref . It exhibits an antiplasmin anti plasmin inhibitory effect and a radioprotective effect in mice ref name Moon ref http www.journalarchive.jst.go.jp english jnlabstract en.php?cdjournal bbb1961&cdvol 53&noissue 11&startpage 3025 An Anti plasmin Inhibitor, Eckol, Isolated from the Brown Alga Ecklonia kurome OKAMURA. Yasuo Nakayama, Masayuki Takahashi, Yoshiyasu Fukuyama and Zyunei Kinzyo, Agricultural and Biological Chemistry, Vol.53 , No.11 19 ... more details
biochemistry receptor for JSRV is hyaluronidase 2 Hyal2 , a glycophosphatidylinol GPI anchored protein belonging to the hyaluronidase family. Generally, oncogenic retroviruses cause Malignant ... more details
List of drugs H Hf Hz hi hm Hi Cor Hibiclens Hibistat hilafilcon B United States Adopted Name USAN hioxifilcon D United States Adopted Name USAN Hippuran i 131 Hipputope Hiprex Hiserpia Hispril Histafed Histalog histapyrrodine International Nonproprietary Name INN histidine International Nonproprietary Name INN histrelin International Nonproprietary Name INN Hivid Hiwolfia HMS ho hu hofocon A United States Adopted Name USAN Homapin homarylamine International Nonproprietary Name INN homatropine methylbromide International Nonproprietary Name INN homidium bromide International Nonproprietary Name INN homochlorcyclizine International Nonproprietary Name INN homofenazine International Nonproprietary Name INN homopipramol International Nonproprietary Name INN homosalate International Nonproprietary Name INN homprenorphine International Nonproprietary Name INN hopantenic acid International Nonproprietary Name INN hoquizil International Nonproprietary Name INN Humalog Human Secretin Votumumab HumaSPECT Humatin Humatrope Zanolimumab HuMax CD4 Zalutumumab HuMax EGFR Humegon Humorsol Humulin hy Hy Pam 25 Hy Phen hya hyc Hyalgan Sanofi Aventis redirects to hyaluronan hyalosidase International Nonproprietary Name INN hyaluronidase International Nonproprietary Name INN hybufocon A United States Adopted Name USAN Hycamtin Hycamtin GlaxoSmithKline hycanthone International Nonproprietary Name INN Hycodan Hycomine hyd hyde Hydeltra TBA Hydeltrasol Hydergine hydr hydra hydre Hydra Zide hydracarbazine International Nonproprietary Name INN hydralazine International Nonproprietary Name INN Hydramine Hydrap ES hydrargaphen International Nonproprietary Name INN Hydrea Hydrea Bristol Myers Squibb hydro Hydro D Hydro Reserp Hydro Ride Hydro Serp hydrob hydrot hydrobentizide International Nonproprietary Name INN Hydrocet hydrochlorothiazide International Nonproprietary Name INN hydrocodone International Nonproprietary Name INN hydrocortamate International Nonproprietary Name INN hydrocortiso ... more details
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