PBB geneid 3454 Interferon alpha beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene . ref name pmid8181059 cite journal author Novick D, Cohen B, Rubinstein M title The human interferon alpha beta receptor characterization and molecular cloning journal Cell volume 77 issue 3 pages 391 400 year 1994 month Jun pmid 8181059 pmc doi 10.1016 0092 8674 94 90154 6 ref ref name entrez cite web title Entrez Gene IFNAR1 interferon alpha, beta and omega receptor 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3454 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. ref name entrez Interactions IFNAR1 has been shown to Protein protein interaction interact with STAT2 , ref name pmid9121453 cite journal last Li first X authorlink coauthors Leung S, Kerr I M, Stark G R year 1997 month Apr. title Functional subdomains of STAT2 required for preassociation with the alpha interferon ... interferon alpha receptor 1 subunit IFNaR1 acts as a docking site for the latent form of the 113 ... alpha beta receptor component IFNAR1 journal J. Biol. Chem. volume 273 issue 38 pages 24723 9 publisher ... A protein arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type ... AC, et al. title Phosphorylated interferon alpha receptor 1 subunit IFNaR1 acts as a docking site ... binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. journal ... and the expression of the interferon alpha beta receptor component IFNAR1. journal J. Biol ... more details
protein Name IFNAR1 interferon alpha, beta and omega receptor 1 caption image width HGNCid 5432 Symbol IFNAR1 AltSymbols IFNAR EntrezGene 3454 OMIM 107450 RefSeq NM 000629 UniProt P17181 PDB ECnumber Chromosome 21 Arm q Band 22.1 LocusSupplementaryData protein Name IFNAR2 interferon alpha, beta and omega receptor 2 caption Protein nuclear magnetic resonance spectroscopy NMR structure of the interferon binding ectodomain of the human interferon receptor. ref name pmid12842042 PDB 1n6u cite journal author Chill JH, Quadt SR, Levy R, Schreiber G, Anglister J title The human type I interferon receptor NMR structure reveals the molecular basis of ligand binding journal Structure volume 11 issue 7 pages 791 802 year 2003 month July pmid 12842042 doi 10.1016 S0969 2126 03 00120 5 url ref image Biochem Mol..png width HGNCid 5433 Symbol IFNAR2 AltSymbols IFNABR EntrezGene 3455 OMIM 602376 RefSeq NM 207585 UniProt P48551 PDB ECnumber Chromosome 21 Arm q Band 22.1 LocusSupplementaryData The interferon receptor IFNAR is a receptor which binds interferon type I type I interferons including interferon and . It is a heteromeric receptor composed of one chain with two subunits referred to as IFNAR1 and IFNAR2 . ref name pmid17969444 cite journal author Uz G, Schreiber G, Piehler J, Pellegrini S title The receptor of the type I interferon family journal Curr. Top. Microbiol. Immunol. volume 316 issue pages 71 95 year 2007 pmid 17969444 doi 10.1007 978 3 540 71329 6 5 ref It is a cell surface receptor. Binding of cytokine follows a JAK STAT signaling pathway . Interferon stimulation results in an immunologic response that is especially associated with viruses. Structure The structure was obtained using NMR. Originally 35 conformers were calculated. This was narrowed to 22 with low energy being the criteria. It was the first helical cytokine receptor s structure to be determined in solution. The molecule has one polymer The structure reveals the nature of binding. A model of the IFNAR2 ... more details
laysource laydate quote ref IFNAR1 ref name pmid9121453 ref name pmid7559568 cite journal last ... Phosphorylated interferon alpha receptor 1 subunit IFNaR1 acts as a docking site for the latent form ... interferon alpha receptor 1 subunit IFNaR1 acts as a docking site for the latent form of the 113 ... more details
accessdate laysummary laysource laydate quote ref IFNAR1 , ref name pmid9029147 cite journal last Abramovich ... arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type ... domain of the IFNAR1 chain in the type I interferon receptor journal EMBO J. volume ... more details
Image 1AU1 Human Interferon Beta01.png thumb 200px The 3D structure of human IFN Human type I interferon s comprise a vast and growing group of IFN proteins. All type I IFNs bind to a specific cell surface receptor complex known as the IFN receptor Interferon alpha beta receptor IFNAR that consists of IFNAR1 and IFNAR2 chains. Homologous molecules to type I IFNs are found in many species, including all mammals, and some have been identified in birds, reptiles, amphibians and fish species. ref Schultz et al., The interferon system of non mammalian vertebrates. Developmental and Comparative Immunology, Volume 28, pages 499 508. ref Mammalian types The mammalian types are designated IFN alpha , IFN beta , IFN kappa , IFN delta , IFN epsilon , IFN tau , IFN omega , and IFN zeta, also known as limitin . ref Oritani and Tomiyama, Interferon limitin Novel type I Interferon that displays a narrow range of biological activity. International journal of hematology, 2004, Volume 80, pages 325 331 . ref ref Hardy et al., Characterization of the type I interferon locus and identification of novel genes. Genomics, 2004, Volume 84 pages 331 345. ref IFN The IFN proteins are produced by leukocytes . They are mainly involved in innate immune response against viral infection. They come in 13 subtypes that are called IFNA1 , IFNA2 , IFNA4 , IFNA5 , IFNA6 , IFNA7 , IFNA8 , IFNA10 , IFNA13 , IFNA14 , IFNA16 , IFNA17 , IFNA21 . These genes for these IFN molecules are found together in a cluster on chromosome 9. IFN is also made synthetically as medication . Types are Pegylated interferon alfa 2a Pegylated interferon alfa 2b IFN The IFN proteins are produced in large quantities by fibroblasts . They have antiviral activity which is mainly involved in innate immune response. Two types of IFN have been described, IFN 1 IFNB1 and IFN 3 IFNB3 ref Todd and Naylor, New chromosomal mapping assignments for argininosuccinate synthetase pseudogene 1, interferon ... more details
PBB geneid 3588 Interleukin 10 receptor, beta subunit is a subunit for the interleukin 10 receptor . IL10RB is its human gene . ref name entrez cite web title Entrez Gene IL10RB interleukin 10 receptor, beta url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3588 accessdate ref IL10RB has also recently been designated CDW210B cluster of differentiation W210B . The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10 induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. ref name entrez cite web title Entrez Gene IL10RB interleukin 10 receptor, beta url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3588 accessdate ref References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Lutfalla G, McInnis MG, Antonarakis SE, Uz G title Structure of the human CRFB4 gene comparison with its IFNAR neighbor. journal J. Mol. Evol. volume 41 issue 3 pages 338 44 year 1995 pmid 7563119 doi 10.1007 BF01215180 cite journal author Lutfalla G, Gardiner K, Uz G title A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR. journal Genomics volume 16 issue 2 pages 366 73 year 1993 pmid 8314576 doi 10.1006 geno.1993.1199 cite journal author Gibbs VC, Pennica D title CRF2 4 isolation of cDNA clones encoding the human and mouse proteins. journal Gene volume 186 issue 1 pages 97 101 year 1997 pmid 9047351 doi 10.1016 S0378 1119 96 00690 7 cite journal author Kotenko SV, Kraus ... more details
format accessdate laysummary laysource laydate quote ref IFNAR1 , ref name pmid9733772 cite journal ... and the expression of the interferon alpha beta receptor component IFNAR1 journal J. Biol. Chem. volume ... more details
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