chembox verifiedrevid 443869434 Name Imidazole ImageFile Imidazole chemical structure.png ImageSize 345px ImageName Chemical structure of imidazole IUPACName 1 H Imidazole OtherNames 1,3 diazole br glyoxaline ... for imidazole and 7.05 for the conjugate acid ref Walba, H. & Isensee, R. W. Acidity constants of some ... Corrosive FlashPt 146 C RPhrases R20 R22 R34 R41 SPhrases S26 S36 S37 S39 S45 RSPhrases Imidazole is an organic ... and as an alkaloid . Derivatives of imidazole, called imidazoles, a common family heterocycles ... an imidazole ring, such as antifungal drug s and nitroimidazole . ref Alan R. Katritzky Rees. Comprehensive Heterocyclic Chemistry. Vol. 5, p.469 498, 1984 . ref ref Grimmett, M. Ross. Imidazole ... 0 582 01421 2 ref Structure and properties Imidazole is a planar 5 membered ring. It exists in two .... Imidazole is a highly polar compound, as evidenced by a calculated dipole of 3.61 debye D . It is highly ... of imidazole are shown below center Image Resonance imidazole.png 550px center crystal structure? Amphotericity Imidazole is amphoteric . That is, it can function as both an acid and as a base. As an acid, the p K sub a sub of imidazole is 14.5, making it less acidic than carboxylic acids, phenols ... between the two is approximately 7, making imidazole approximately sixty times more basic than pyridine .... Preparation Imidazole was first reported in 1858, although various imidazole derivatives had been discovered ... to form imidazole or glyoxaline, as it was originally named . ref cite journal title Ueber die ... Howard, Jessica L. Zile, Jennifer L. Barker, Kathryn H. J. Chem. Educ. 2006 83 1658 ref Image Imidazole ball and stick.png right thumb 150px A ball and stick model of imidazole, showing carbon carbon and a carbon nitrogen double bonds Imidazole can be synthesized by numerous methods besides the Debus method. Many of these syntheses can also be applied to different substituted imidazoles and imidazole ... by which and how many bonds form to make the imidazole rings. For example, the Debus method forms ... more details
enzyme Name imidazole N acetyltransferase EC number 2.3.1.2 CAS number 9029 89 4 IUBMB EC number 2 3 1 2 GO code 0047716 image width caption In enzymology , an imidazole N acetyltransferase EC number 2.3.1.2 is an enzyme that catalysis catalyzes the chemical reaction acetyl CoA imidazole math rightleftharpoons math CoA N acetylimidazole Thus, the two substrate biochemistry substrates of this enzyme are acetyl CoA and imidazole , whereas its two product chemistry products are coenzyme A CoA and N acetylimidazole . This enzyme belongs to the family of transferase s, specifically those acyltransferase s transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl CoA imidazole N acetyltransferase . Other names in common use include imidazole acetylase , and imidazole acetyltransferase . References reflist 1 cite journal author Kinsky SC date 1960 title Assay, purification, and properties of imidazole acetylase journal J. Biol. Chem. volume 235 pages 94&ndash 98 pmid 14409246 transferase stub Category EC 2.3.1 Category Enzymes of unknown structure it Imidazolo N acetiltransferasi ... more details
enzyme Name purine imidazole ring cyclase EC number 4.3.2.4 CAS number 95990 28 6 IUBMB EC number 4 3 2 4 GO code 0050230 image width caption In enzymology , a purine imidazole ring cyclase EC number 4.3.2.4 is an enzyme that catalysis catalyzes the chemical reaction DNA 4,6 diamino 5 formamidopyrimidine math rightleftharpoons math DNA adenine H sub 2 sub O Hence, this enzyme has one substrate biochemistry substrate , DNA 4,6 diamino 5 formamidopyrimidine , and two product chemistry products , DNA adenine and water H sub 2 sub O . This enzyme belongs to the family of lyase s, specifically amidine lyases. The systematic name of this enzyme class is DNA 4,6 diamino 5 formamidopyrimidine C8 N9 lyase cyclizing DNA adenine forming . Other names in common use include DNA 4,6 diamino 5 formamidopyrimidine 8 C,9 N lyase cyclizing , DNA 4,6 diamino 5 formamidopyrimidine 8 C,9 N lyase cyclizing , and DNA adenine forming . References reflist 1 cite journal author Chetsanga CJ, Grigorian C date 1985 title In situ enzymatic reclosure of opened imidazole rings of purines in DNA damaged by gamma irradiation journal Proc. Natl. Acad. Sci. U.S.A. volume 82 pages 633&ndash 7 pmid 3856219 doi 10.1073 pnas.82.3.633 issue 3 pmc 397099 enzyme stub Category EC 4.3.2 Category Enzymes of unknown structure ... more details
The Debus Radziszewski imidazole synthesis is an organic reaction describing the synthesis of an imidazole from a diketone , an aldehyde and ammonia . It is an example of a multicomponent reaction . In step one the diketone and ammonia form an imine diimine Image Radziszewski Synthese 2.svg 400px Debus Radziszewski imidazole synthesis part I In the second step the diimine condensation reaction condenses with the aldehyde Image Radziszewski Synthese 1.svg 400px Debus Radziszewski imidazole synthesis part I This reaction is named after Heinrich Debus chemist Heinrich Debus ref cite journal title Ueber die Einwirkung des Ammoniaks auf Glyoxal journal Justus Liebigs Annalen der Chemie doi 10.1002 jlac.18581070209 year 1858 last1 Debus first1 Heinrich volume 107 issue 2 pages 199 ref and Bronis aw Leonard Radziszewski ref cite journal title Ueber Glyoxalin und seine Homologe journal Berichte der deutschen chemischen Gesellschaft doi 10.1002 cber.188201502245 year 1882 last1 Radzisewski first1 Br. volume 15 issue 2 pages 2706 ref ref On the development of organic chemistry in Ukraine Dmytro O. Tymoshenko ARKIVOC 2005 viii 1 3 http www.arkat usa.org get file 20567 Link ref A modification of this general method, where one equivalent of ammonia is replaced by an amine, affords N substituted imidazoles in good yields. ref US patent reference number 6,177,575 y 2001 m 01 d 23 inventor Anthony Joseph Arduengo III A. J. Arduengo title Process for Manufacture of Imidazoles ref Image Arduengo imidazoles.png 400px Arduengo imidazoles References Reflist Category Name reactions de Radziszewski Synthese zh Debus Radziszewski ... more details
enzyme Name 5 carboxyamino imidazole ribonucleotide synthase EC number 6.3.4.18 CAS number IUBMB EC number 6 3 4 18 GO code image width caption In enzymology , a 5 carboxyamino imidazole ribonucleotide synthase EC number 6.3.4.18 is an enzyme that catalysis catalyzes the chemical reaction ATP 5 amino 1 5 phospho D ribosyl imidazole HCO sub 3 sub sup &minus sup math rightleftharpoons math ADP phosphate 5 carboxyamino 1 5 phospho D ribosyl imidazole The 3 substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP , 5 amino 1 5 phospho D ribosyl imidazole AIR , and bicarbonate HCO sub 3 sub sup &minus sup , whereas its 3 product chemistry products are adenosine diphosphate ADP , phosphate , and 5 carboxyamino 1 5 phospho D ribosyl imidazole . This enzyme belongs to the family of ligase s, specifically those forming generic carbon nitrogen bonds. The systematic name of this enzyme class is 5 amino 1 5 phospho D ribosyl imidazole carbon dioxide ligase ADP forming . Other names in common use include N5 CAIR synthetase , N5 carboxyaminoimidazole ribonucleotide synthetase , and PurK . References reflist 1 cite journal author Meyer E, Leonard NJ, Bhat B, Stubbe J, Smith JM date 1992 title Purification and characterization of the purE, purK, and purC gene products identification of a previously unrecognized energy requirement in the purine biosynthetic pathway journal Biochemistry. volume 31 pages 5022&ndash 32 pmid 1534690 doi 10.1021 bi00136a016 issue 21 cite journal author Mueller EJ, Meyer E, Rudolph J, Davisson VJ, Stubbe J date 1994 title N5 carboxyaminoimidazole ribonucleotide evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli journal Biochemistry. volume 33 pages 2269&ndash 78 pmid 8117684 doi 10.1021 bi00174a038 issue 8 cite journal author Thoden JB, Kappock TJ, Stubbe J, Holden HM date 1999 title Three dimensional structure of N5 carboxyaminoimidazole ribonucleotide synthetase ... more details
enzyme Name 5 carboxyamino imidazole ribonucleotide mutase EC number 5.4.99.18 CAS number IUBMB EC number 5 4 99 18 GO code image width caption In enzymology , a 5 carboxyamino imidazole ribonucleotide mutase EC number 5.4.99.18 is an enzyme that catalysis catalyzes the chemical reaction 5 carboxyamino 1 5 phospho D ribosyl imidazole math rightleftharpoons math 5 amino 1 5 phospho D ribosyl imidazole 4 carboxylate Hence, this enzyme has one substrate biochemistry substrate , 5 carboxyamino 1 5 phospho D ribosyl imidazole , and one product chemistry product , 5 amino 1 5 phospho D ribosyl imidazole 4 carboxylate . This enzyme belongs to the family of isomerase s, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is 5 carboxyamino 1 5 phospho D ribosyl imidazole carboxymutase . Other names in common use include N5 CAIR mutase , PurE , N5 carboxyaminoimidazole ribonucleotide mutase , and class I PurE . References reflist 1 cite journal author Meyer E, Leonard NJ, Bhat B, Stubbe J, Smith JM date 1992 title Purification and characterization of the purE, purK, and purC gene products identification of a previously unrecognized energy requirement in the purine biosynthetic pathway journal Biochemistry. volume 31 pages 5022&ndash 32 pmid 1534690 doi 10.1021 bi00136a016 issue 21 cite journal author Mueller EJ, Meyer E, Rudolph J, Davisson VJ, Stubbe J date 1994 title N5 carboxyaminoimidazole ribonucleotide evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli journal Biochemistry. volume 33 pages 2269&ndash 78 pmid 8117684 doi 10.1021 bi00174a038 issue 8 cite journal author Meyer E, Kappock TJ, Osuji C, Stubbe J date 1999 title Evidence for the direct transfer of the carboxylate of N5 carboxyaminoimidazole ribonucleotide N5 CAIR to generate 4 carboxy 5 aminoimidazole ribonucleotide catalyzed by Escherichia coli PurE, an N5 CAIR mutase journal ... more details
Unreferenced date December 2009 Diazole refers to either one of a pair of isomer ic chemical compound s with molecular formula C sub 3 sub H sub 4 sub N sub 2 sub , having a five membered ring consisting of three carbon atoms and two nitrogen atoms. The two isomers are Imidazole 1,3 diazole image Imidazole chemical structure.png Pyrazole 1,2 diazole image Pyrazole numbering.png 80px Category Diazoles ja zh ... more details
DISPLAYTITLE C sub 3 sub H sub 4 sub N sub 2 sub C sub 3 sub H sub 4 sub N sub 2 sub may refer to Compounds sharing the molecular formula Imidazole Pyrazole MolFormDisambig heading 3 ar C3H4N2 fr C3H4N2 it C3H4N2 lv C3H4N2 ... more details
PVI may refer to People Pope Paul VI , the pope of the Roman Catholic Church from 1963 1978 born as Giovanni Battista Enrico Antonio Maria Montini Peter van Inwagen , American philosopher Companies PVI Virtual Media Services , virtual advertising and imaging company Power Vehicle Innovation , the french electric and natural gas bus and truck manufacturer Other Paul VI Catholic High School in Fairfax, Virginia, which is named for Pope Paul VI Paul VI High School in Haddonfield, New Jersey, also named for Pope Paul VI Cook Partisan Voting Index Polyvinyl Isobutyl Ether , Polyvinyl with Isobutyl Ether substituents Polyvinyl Imidazole , Polyvinyl with Imidazole substituents Disambig fr PVI it PVI ... more details
In chemistry , residue is the material remaining after a distillation or an evaporation, or to a portion of a larger molecule, such as a methyl group . It may also refer to the undesired byproducts of a reaction. In biochemistry and molecular biology , a residue refers to a specific monomer within the polymer polymeric chain of a polysaccharide , protein or nucleic acid . For example, one might say, This protein consists of 118 amino acid residues or The histidine residue is considered to be basic due to its imidazole ring. Note that a residue is different from a Functional group moiety , which, in the above example would be constituted by the imidazole ring or the imidazole moiety . Note the origin of this usage during the process by which monomer ic building blocks e.g. amino acid s are strung together into a polymeric chain e.g. a protein , some material typically adding up to one molecule of water is discarded from each building block, and only a residue of the building block ends up in the finished product. For instance, a residue is an individual amino acid in a peptide chain. Interlang Category Distillation Chemistry stub de R ckstand Chemie nl Residu scheikunde ja tr Kal nt biyokimya zh pl Osad chemia ... more details
chembox verifiedrevid 443869801 ImageFile Imidazoline numbering.png ImageSize 120px IUPACName 4,5 Dihydro 1 H imidazole OtherNames Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 61464 InChI 1 C3H6N2 c1 2 5 3 4 1 h3H,1 2H2, H,4,5 InChIKey MTNDZQHUAFNZQY UHFFFAOYAB StdInChI Ref stdinchicite correct chemspider StdInChI 1S C3H6N2 c1 2 5 3 4 1 h3H,1 2H2, H,4,5 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey MTNDZQHUAFNZQY UHFFFAOYSA N CASNo Ref cascite correct CAS CASNo 504 75 6 PubChem 68156 ChEBI Ref ebicite correct EBI ChEBI 53094 SMILES N 1 C NCC 1 Section2 Chembox Properties C 3 H 6 N 2 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Imidazoline is a nitrogen containing heterocyclic compound heterocycle with formula C sub 3 sub H sub 6 sub N sub 2 sub , derived from imidazole . The ring contains an imine bond, and the carbons at the 4 and 5 positions are singly bonded, rather than doubly bonded for the case of imidazole. Imidazolines are structurally related to guanidine s and amidine s. Image ImChem.png thumb left 450px Chemical relationship of imidazole to its reduced derivatives. br style clear left Image Grubbs Catalyst 2nd Generation.png right thumb Second generation Grubbs catalyst Like imidazole, imidazoline based compounds have been used as N heterocyclic carbene ligands on various transition metals. It is found in the commercially available second generation Grubbs catalyst . Biological role Many imidazolines are biologically active. ref cite journal author N. MacInnes and S. Duty title Locomotor effects of imidazoline I2 site specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6 hydroxydopamine lesion of the nigrostriatal pathway year 2004 journal Br J Pharmacol volume 143 issue 8 pages 952 959 doi 10.1038 sj.bjp.0706019 pmid 15545290 pmc 1575965 ref Most bio active derivatives bear a substituent aryl or alkyl group ... more details
chembox Verifiedfields changed verifiedrevid 477224023 ImageFile Aminoimidazole ribotide.svg ImageSize IUPACName 5 5 amino imidazole imidazol 1 yl 3,4 dihydroxy oxolane oxolan 2 yl methyl dihydrogen phosphate OtherNames AIR, br 5 5 amino 1 imidazolyl 3,4 dihydroxy 2 tetrahydrofuranyl methyl dihydrogen phosphate Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 141854 StdInChI Ref stdinchicite correct chemspider StdInChI 1S C8H14N3O7P c9 5 1 10 3 11 5 8 7 13 6 12 4 18 8 2 17 19 14,15 16 h1,3 4,6 8,12 13H,2,9H2, H2,14,15,16 t4 ,6 ,7 ,8 m1 s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey PDACUKOKVHBVHJ XVFCMESISA N CASNo Ref cascite changed ?? CASNo 25635 88 5 ChEBI Ref ebicite changed EBI ChEBI 28843 KEGG Ref keggcite changed kegg KEGG C03373 PubChem 153 SMILES O P O O OC C H 2O C H n1cncc1N C H O C H 2O MeSHName aminoimidazole ribotide Section2 Chembox Properties Formula C sub 8 sub H sub 14 sub N sub 3 sub O sub 7 sub P MolarMass 295.186 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition 5 Phosphoribosyl 5 aminoimidazole or aminoimidazole ribotide is an intermediate in the formation of purine s. Thus, it is an intermediate in the adenine pathway , and is synthesized from 5 phosphoribosylformylglycinamidine by AIR synthetase . See also Phosphoribosylaminoimidazole carboxylase 5 carboxyamino imidazole ribonucleotide synthase 5 carboxyamino imidazole ribonucleotide mutase Nucleotide metabolism intermediates DEFAULTSORT Aminoimidazole ribotide, 5 Category Nucleotides biochemistry stub ... more details
HIS can refer to Hangzhou International School HIS Hightech Information System Limited Hospital Infection Society Hospital information system Hotel information system Hybrid intelligent system Japanese people Japanese travel agent H.I.S. Harare International School , an international school in Harare , Zimbabwe Hollands Inlands School , an international school in Indonesia Histidine , an amino acid with an imidazole side chain Host Integration Server , a software product from Microsoft disambig de HIS fa HIS it HIS ja HIS sk HIS ... more details
Hexaarylbiimidazole HABI is an organic compound and a imidazole derivative. In its natural state, HABI is colorless, but when ultraviolet light breaks one of the bonds in the molecule, it produces a version that is dark blue. The transformation takes ten seconds or longer. ref Photochromism of a Radical Diffusion Inhibited Hexaarylbiimidazole Derivative with Intense Coloration and Fast De coloration Performance Kana Fujita, Sayaka Hatano, Daisuke Kato and Jiro Abe Org. Lett., 2008, 10 14 , pp 3105 3108 2008 DOI 10.1021 ol801135g ref By adding naphthalene to the compound, the color transition can be made in about 180 milliseconds. The cyclophane version of HABI reverts back to colorless just as fast as the UV light is off. See also Photochromism References Reflist External links http sciencenow.sciencemag.org cgi content full 2009 424 1 Category Imidazoles Category Chromism heterocyclic stub ... more details
Econazole triamcinolone is a combination drug , consisting of econazole an imidazole antifungal and triamcinolone a group III topical steroid . It is used as a topical administration topical cream against fungal skin infections , including trichophyton mentagrophytes , T. rubrum , epidermophyton floccosum and candida albicans . ref http www.cabdirect.org abstracts 19811372965.html?freeview true Treatment of inflammatory skin mycoses with Pevisone cream econazole triamcinolonacetomide . By Graber, W. Praxis 1980 Vol. 69 No. 3 pp. 87 93. Record Number 19811372965 ref . In Bangladesh , the combination of Triamcinolone acetonide and Econazole nitrate is branded as Pevisone by Sanofi Aventis . References reflist Category Combination drugs Category Antifungal drugs Category Article Feedback 5 ... more details
as histidine and histamine, Basicity With the N methyl group, this particular derivative of imidazole cannot tautomerize. It is slightly more basic than imidazole, as indicated by the pKa s of the conjugate .... The main one is acid catalysed methylation of imidazole by methanol. The second method involves the Debus Radziszewski imidazole synthesis Radziszewski reaction from glyoxal , formaldehyde , and a mixture ..., R. Imidazole and Derivatives. In Ullmann s Encyclopedia of Industrial Chemistry 2002 Wiley VCH, DOI ... 3 H sub 2 sub O The compound can prepare be synthesized on a laboratory scale by methylation of imidazole ... may be synthesized by first deprotonating imidazole to form a sodium salt followed by methylation. ref Grimmett, M. R., Imidazole and Benzimidazole Synthesis 1997 Academic Press, ISBN 0 12 303190 ... and related derivatives have been used as mimic aspects of diverse imidazole based biomolecules ... imidazole polyamides. These polymers can selectively bind specific sequences of double stranded DNA ... more details
Corrosive Section8 Chembox Related Function OtherFunctn OtherCpds phosgene , imidazole 1,1 ... straightforwardly by the reaction of phosgene with four equivalents of imidazole under anhydrous conditions ... ref 4 imidazole C sub 3 sub H sub 4 sub N sub 2 sub C O Cl sub 2 sub C sub 3 sub H sub 3 sub N sub 2 sub sub 2 sub CO 2 C sub 3 sub H sub 3 sub N sub 2 sub H sub 2 sub Cl In this conversion, the imidazole serves both as the nucleophile and the base. An alternative precursor 1 trimethylsilyl imidazole ... back imidazole C sub 3 sub H sub 3 sub N sub 2 sub sub 2 sub CO H sub 2 sub O 2 C sub 3 sub H sub .... ref name eeros An early application of this type of reaction was noted in the formation of imidazole ... the imidazole group and couple the peptides. The side products, carbon dioxide and imidazole, are relatively ... 1 ratio that forms an insoluble salt with the imidazole, such as trifluoro or trichloroacetic acid and thus removes the free imidazole from the reaction . Symmetric anhydrides can thus be formed by replacing ... reagent. Another related reaction is the reaction of formic acid with CDI to form the formylized imidazole ... imidazole with formation of carbon monoxide upon heating. Yet another reaction involves the acylation ... acid , which can react further to form diacyl peroxides. The imidazole group is also ... of Asymmetric Dialkyl and Cyclic Carbonates Using the Highly Selective Reactions of Imidazole ... more details
Chembox Verifiedfields changed Watchedfields changed verifiedrevid 419241295 ImageFile Imidazolidine numbering.png ImageSize 120px IUPACName Imidazolidine OtherNames Tetrahydroimidazole Section1 Chembox Identifiers CASNo Ref cascite correct ?? CASNo 504 74 5 PubChem 449488 ChemSpiderID Ref chemspidercite changed chemspider ChemSpiderID 396007 SMILES N1CCNC1 InChI 1 C3H8N2 c1 2 5 3 4 1 h4 5H,1 3H2 InChIKey WRYCSMQKUKOKBP UHFFFAOYAC StdInChI Ref stdinchicite changed chemspider StdInChI 1S C3H8N2 c1 2 5 3 4 1 h4 5H,1 3H2 StdInChIKey Ref stdinchicite changed chemspider StdInChIKey WRYCSMQKUKOKBP UHFFFAOYSA N Section2 Chembox Properties C 3 H 8 N 2 MolarMass 72.109 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Imidazolidine is a heterocyclic compound formally derived by the addition of four hydrogen atoms to imidazole . The intermediate, resulting from the addition of only two hydrogen atoms is called dihydroimidazole imidazoline . The connection of imidazolidine to related compounds is indicated in the Figure. Image ImChem.png center thumb 600px Figure. Chemical relationship of imidazole to its reduced derivatives. Formally, removal of the two hydrogens at carbon 2 between the two nitrogens would yield the carbene dihydroimidazol 2 ylidene . Derivatives of the latter comprise an important class of persistent carbene s. ref name Arduengo2 Cite journal author A. J. Arduengo, H. V. R. Dias, R. L. Harlow, and M. Kline title Electronic stabilization of nucleophilic carbenes journal J. Am. Chem. Soc. year 1992 volume 114 pages 5530 doi 10.1021 ja00040a007 issue 14 ref References Reflist Category Imidazolidines Heterocyclic stub fa fr Imidazolidine nl Imidazolidine pl Imidazolidyna ... more details
Drugbox verifiedrevid 437158174 IUPAC name RS 1 2 fluorophenyl 4 fluorophenyl benzyl 1 H imidazole image Flutrimazole.png width 200px imagename 1 1 mixture racemate drug name Flutrimazole Clinical data tradename Drugs.com drugs.com international flutrimazole pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU Unscheduled S2 S3 S4 S5 S6 S7 S8 S9 legal CA Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL P POM CD Class A, B, C legal US OTC Rx only Schedule I, II, III, IV, V legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers CAS number 119006 77 8 ATC prefix D01 ATC suffix AC16 ATC supplemental ATC G01 AF18 PubChem 3401 DrugBank Ref drugbankcite correct drugbank DrugBank ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 3284 UNII Ref fdacite correct FDA UNII 776S0UP252 KEGG Ref keggcite correct kegg KEGG D07193 Chemical data C 22 H 16 F 2 N 2 molecular weight 346.373 g mol smiles Fc1ccc cc1 C c2c F cccc2 c3ccccc3 n4ccnc4 InChI 1 C22H16F2N2 c23 19 12 10 18 11 13 19 22 26 15 14 25 16 26,17 6 2 1 3 7 17 20 8 4 5 9 21 20 24 h1 16H InChIKey QHMWCHQXCUNUAK UHFFFAOYAR StdInChI Ref stdinchicite correct chemspider StdInChI 1S C22H16F2N2 c23 19 12 10 18 11 13 19 22 26 15 14 25 16 26,17 6 2 1 3 7 17 20 8 4 5 9 21 20 24 h1 16H StdInChIKey Ref stdinchicite correct chemspider StdInChIKey QHMWCHQXCUNUAK UHFFFAOYSA N Flutrimazole is a wide spectrum Antifungal medication antifungal drug. It is used for the topical treatment of superficial mycosis mycoses of the skin . Flutrimazole is an imidazole derivative. It interferes with the synthesis of ergosterol by inhibiting the activity of the enzyme lanosterol 14 demethylase . References refbegin The Merck Index, 12th Edition. 4247 refend Gynecological anti infectives and antiseptics Category Antifungals Category Organofluorides Category Imidazoles antiinfective drug stub genito urinary drug stub pl Flutrimazol ... more details
Unreferenced date December 2011 Drugbox IUPAC name 1 1 2 3 chlorophenyl methoxy phenyl ethenyl 1 H imidazole image Croconazole.png Clinical data tradename Drugs.com drugs.com international croconazole pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled legal CA Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL, P, POM, CD, or Class A, B, C legal US OTC Rx only Schedule I, II, III, IV, V legal status Rx only routes of administration Topical Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers CAS number 77175 51 0 ATC prefix none ATC suffix ATC supplemental PubChem 2880 DrugBank ChemSpiderID 2777 UNII Ref fdacite correct FDA UNII 446254H55G KEGG D07752 ChEMBL 27289 Chemical data chemical formula C 18 H 15 Cl 1 N 2 O 1 molecular weight 310.77 g mol smiles Clc1cccc c1 COc3c C C n2ccnc2 cccc3 InChI 1 C18H15ClN2O c1 14 21 10 9 20 13 21 17 7 2 3 8 18 17 22 12 15 5 4 6 16 19 11 15 h2 11,13H,1,12H2 InChIKey WHPAGCJNPTUGGD UHFFFAOYAC Croconazole International Nonproprietary Name INN is an imidazole Antifungal medication antifungal . pharma stub Antifungals Category Antifungals Category Imidazoles Category Organochlorides Category Phenol ethers Category Alkenes ... more details
Orphan date October 2008 Chembox Name 1 n Butyl 3 methylimidazolium ImageFile 1 butyl 3 methylimidazolium.svg ImageFile Ref chemboximage correct ?? ImageSize 244 ImageName Kekul , skeletal formula of a 1 n Butyl 3 methylimidazolium minor tautomer Section1 Chembox Identifiers PubChem 2734162 PubChem Ref Pubchemcite correct pubchem ChemSpiderID 2015918 ChemSpiderID Ref chemspidercite correct chemspider ChEBI 61333 ChEMBL 1198608 ChEMBL Ref ebicite correct EBI SMILES CCCC n 1ccn C c1 StdInChI 1S C8H15N2 c1 3 4 5 10 7 6 9 2 8 10 h6 8H,3 5H2,1 2H3 q 1 StdInChIKey IQQRAVYLUAZUGX UHFFFAOYSA N Section2 Chembox Properties Formula Chem C 8 H 15 N 2 sup sup MolarMass 139.2181 g mol sup 1 sup ExactMass 139.123523490 g mol sup 1 sup C4mim is a shorthand for 1 n butyl 3 methylimidazolium salts. These are ionic liquids based on imidazole chemistry. A common example of such is C4mim Cl , or 1 n butyl 3 methylimidazolium chloride. These salts are currently of interest in industry due their ability to be infinitely recycled and their amenability to solvation at room temperature, making them excellent green solvents. C4mim is based on the parent compound 1 butyl 3 methylimidazole with one electron removed from the imidazole arene group. The stability of this cation lies in the fact that the resulting electronic vacancy is delocalised across the arene group, albeit unequally so. File 1 butyl 3 methylimidazolium chloride.svg thumb left Chemical structure of 1 n butyl 3 methylimidazolium chloride clear left See also Ethylammonium nitrate References http www.epa.gov greenchemistry pubs pgcc winners aa05.html Press release from the EPA describing the use of C4mim. Aromatic stub Heterocyclic stub Category Ionic liquids Category Solvents fa ... more details
Orphan date April 2012 Expert subject medicine date November 2008 Myocardial depressant factor MDF is a low molecular weight peptide ref MeshName Myocardial Depressant Factor ref released from the pancreas into the blood in mammals during various Shock circulatory shock states. ref name pmid6181287 cite journal author Lefer AM title The pathophysiologic role of myocardial depressant factor as a mediator of circulatory shock journal Klin. Wochenschr. volume 60 issue 14 pages 713 6 year 1982 month July pmid 6181287 doi 10.1007 BF01716561 url ref MDF is a significant mediator of shock pathophysiology, reducing myocardial contractility, constricting splanchnic arteries and impairing phagocytosis by the reticuloendothelial system . Survival can be improved by preventing its release or blocking its activity, for example using glucocorticoids , prostaglandin s, aprotinin , captopril , imidazole or lidocaine . References reflist Category Peptides Category Cardiology med stub ... more details
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