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Insulin like growth factor 1
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Encyclopedia results for Insulin like growth factor 1

Insulin like growth factor 1





Encyclopedia results for Insulin like growth factor 1

  1. Insulin-like growth factor 1 receptor

    PBB geneid 3480 The Insulin like Growth Factor 1 IGF 1 Receptor is a protein found on the surface of human ... that is activated by a hormone called Insulin like growth factor 1 IGF 1 and by a related hormone called ... DR, Poulsom R, Brewster SF, Macaulay VM title Expression of the type 1 insulin like growth factor ..., Garan SA, Gouw AM, Voelker MA, Sternberg H, Timiras PS title Insulin like growth factor 1 receptor ... figitumumab . Interactions Insulin like growth factor 1 receptor has been shown to Protein protein ... for the direct interaction of the insulin like growth factor I receptor with IRS 1, Shc, and Grb10 ... regulatory subunit of phosphatidylinositol 3 kinase with insulin like growth factor 1 signaling proteins ... M year 2001 month Aug. title Association of insulin like growth factor 1 receptor with EHD1 ... interaction of SHC and the insulin receptor substrate 1 IRS 1 with the insulin like growth factor ... IGF1R insulin like growth factor 1 receptor in tongue squamous cell carcinoma cells journal Biochemical ... like growth factor 2 receptor IGF 2R and their respective ligands IGF 1 and IGF 2 , along ... Echeverr a C, Hofmann F, Krystal GW title The insulin like growth factor I receptor kinase inhibitor ... M, Barrow D, Knowlden JM, Williams S, Wakeling AE, Nicholson RI title Insulin like growth factor ... like growth factor 1 receptor immunoreactive cells in the supraoptic hypothalamus is reduced ... 3 protein interacts with the insulin like growth factor I receptor journal Biochem. Biophys. Res. Commun ... M year 1995 month Aug. title Localization of the insulin like growth factor I receptor binding sites ... SOCS 2 with the insulin like growth factor I receptor journal J. Biol. Chem. volume 273 issue 37 ... regulates ligand induced ubiquitination and stability of the insulin like growth factor I receptor ..., insulin like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology ... of the insulin like growth factor I receptor journal Cancer Res. volume 56 issue 14 pages 3165 ...   more details



  1. Insulin-like growth factor 1

    PBB geneid 3479 Insulin like growth factor 1 IGF 1 is also called somatomedin C is a protein that in humans ... is mediated by binding to its specific receptor, the Insulin like growth factor 1 receptor , abbreviated ... serum insulin like growth factor I concentration journal J Anim Sci volume 77 issue 4 pages 835 9 year 1999 pmid 10328346 ref Insulin like growth factor 1 receptor IGF 1R and other tyrosine kinase ... 1R. As the name insulin like growth factor 1 implies, IGF 1 is structurally related to insulin, and is even ... has for its receptor, Insulin like growth factor 1 receptor IGFR , its binding does not interfere with IGF ... Interactions Insulin like growth factor 1 has been shown to bind and interact with all the IGF 1 Binding ... to insulin like growth factor binding proteins 1 6 journal J. Biol. Chem. volume 268 issue 13 pages ... Insulin like growth factor 1 as a vascular protective factor journal Circulation volume 110 issue ... and insulin like growth factor 1 abnormalities in antipsychotic naive schizophrenia journal Am J Psychiatry ... Growth factors Hormones DEFAULTSORT Insulin Like Growth Factor 1 Category Peptide hormones Category ... The human gene encoding insulin like growth factor I is located on chromosome 12 journal Hum. Genet ... JC, Tong PC., Glucose lowering effect of transgenic human insulin like growth factor I from rice ... to the insulin like effects, IGF 1 can also regulate cell growth and development, especially ... related to a second protein called Insulin like growth factor 2 IGF 2 . IGF 2 also binds the IGF ... significant insulin like growth factor I receptor mutations in centenarians journal PNAS date 2008 ... of serum total testosterone and insulin like growth factor I in adult men journal Steroids volume ... cite journal author Scarth J title Modulation of the growth hormone insulin like growth factor GH IGF ... author Velcheti V, Govindan R title Insulin like growth factor and lung cancer journal Journal of thoracic ... pmid17630612 cite journal author Rosenbloom AL title The role of recombinant insulin like growth factor ...   more details



  1. Insulin-like growth factor

    ligand s IGF 1 and IGF 2 , a family of six high affinity Insulin like growth factor binding protein IGF binding proteins IGFBP 1 6 , as well as associated Insulin like growth factor binding protein IGFBP ... referred to as the Growth Hormone IGF1 Axis. Insulin like growth factor 1 IGF 1 is mainly secreted by the liver as a result of stimulation by growth hormone GH . IGF 1 is important for both the regulation ... 4522 97 00539 3 ref See also Insulin like growth factor 1 Insulin like growth factor 2 Growth hormone ...Image 3GF1 Insulin Like Growth Factor Nmr 10 01.png thumb ILGF The insulin like growth factors IGFs are protein ... death apoptosis . Insulin like growth factor 2 IGF 2 is thought to be a primary growth factor required for early development while IGF 1 expression is required for achieving maximal growth. Gene ... like Growth Factor I and Insulin like Growth Factor Binding Protein 3 with Intelligence Quotient ... PDR.0b013e3181425869 ref IGF Receptors The IGF s are known to bind the IGF 1 receptor , the insulin receptor , the insulin like growth factor 2 receptor IGF 2 receptor , the insulin related receptor ... R, Goldfine ID, Pezzino V year 1993 title Insulin like growth factor I receptors are overexpressed ... hormone insulin like growth factor GH IGF axis by pharmaceutical, nutraceutical and environmental ... like growth factor 1 messenger RNA expression are severely attenuated in middle aged and aged rats ... higher affinity than it binds the insulin receptor. Like the insulin receptor, the IGF 1 ... . IGF Binding Proteins IGF 1 and IGF 2 are regulated by a family of proteins known as the Insulin like growth factor binding protein IGF Binding Proteins . These proteins help to modulate IGF ... 6 pages 672 86 pmid 11274053 pmc 312654 doi 10.1101 gad.867301 ref that are insulin like or IGF 1 like ... RG year 1991 title Insulin like growth factors IGFs , IGF receptors, and IGF binding proteins ... tissue types express the IGF 1 receptor , IGF 1 s effects are diverse. It acts as a neurotrophic factor ...   more details



  1. Insulin-like growth factor II IRES

    Infobox rfam Name Insulin like growth factor II IRES image RF00483.jpg width caption Predicted secondary structure and sequence conservation of IRES IGF2 Symbol IRES IGF2 AltSymbols Rfam RF00483 miRBase miRBase family RNA type Cis regulatory element Cis reg Internal ribosome entry site IRES Tax domain Eukaryota GO GO 0043022 SO SO 0000243 CAS number EntrezGene HGNCid OMIM PDB RefSeq Chromosome Arm Band LocusSupplementaryData The insulin like growth factor II IGF II internal ribosome entry site Internal ribosome entry site IRES is found in the 5 UTR of Insulin like growth factor 2 IGF II leader 2 mRNA . This cis regulatory element RNA element allows cap independent translation of the mRNA and it is thought that this family may facilitate a continuous IGF II production in rapidly dividing cells during development. ref cite journal last Pedersen first SK coauthors Christiansen J, Hansen TO, Larsen MR, Nielsen FC year 2002 title Human insulin like growth factor II leader 2 mediates internal initiation of translation journal Biochem J volume 363 pages 37&ndash 44 pmid 11903044 doi 10.1042 0264 6021 3630037 issue Pt 1 pmc 1222448 ref References reflist 1 External links Rfam id RF00483 name Insulin like growth factor II IRES http iresite.org IRESite web.php?page view&entry id 337 IRESite page for IGF2 leader2 Category Cis regulatory RNA elements molecular cell biology stub ...   more details



  1. Insulin-like growth factor-binding protein

    Pfam box Symbol IGFBP Name Insulin like growth factor br binding protein image PDB 1boe EBI.jpg width caption Structure of the IGF binding domain of the insulin like growth factor binding protein 5 IGFBP 5 . ref name pmid9822601 cite journal author Kalus W, Zweckstetter M, Renner C, et al. title Structure of the IGF binding domain of the insulin like growth factor binding protein 5 IGFBP 5 implications for IGF and IGF I receptor interactions journal EMBO J. volume 17 issue 22 pages 6558 72 year 1998 month November pmid 9822601 pmc 1171003 doi 10.1093 emboj 17.22.6558 url ref Pfam PF00219 InterPro IPR000867 SMART SM00121 PROSITE PDOC00194 SCOP 1boe TCDB OPM family OPM protein PDB PDB2 1boe , PDB2 1h59 The Insulin like growth factor binding protein also known as IGFBP serves as a carrier protein for Insulin like growth factor 1 IGF 1 . ref name pmid10605625 cite journal author Hwa V, Oh Y, Rosenfeld RG title The insulin like growth factor binding protein IGFBP superfamily journal Endocr. Rev. volume 20 issue 6 pages 761 87 year 1999 month December pmid 10605625 doi 10.1210 er.20.6.761 url issn ref Function Approximately 98 of IGF 1 is always bound to one of 6 binding proteins IGF BP . IGFBP 3, the most abundant protein, accounts for 80 of all IGF binding. IGF 1 binds to IGFBP 3 in a 1 1 molar ratio. IGF BP also binds to IGF 1 inside the liver, allowing growth hormone to continuously act upon the liver to produce more IGF 1. This is important because proliferating IGF 1 IGF BP complex allow growth of the femur and the muscle. fact date May 2011 IGF binding proteins IGFBPs are proteins ... title Role of insulin like growth factor binding proteins in the control of IGF actions journal Prog. Growth Factor Res. volume 6 issue 2 4 pages 357 66 year 1995 pmid 8817679 doi 10.1016 0955 2235 ... SM, Pell JM title Potentiation of insulin like growth factor I IGF I activity by an antibody ... Reflist External links MeshName Insulin like growth factor binding proteins biochemistry stub Carrier ...   more details



  1. Insulin-like growth factor 2

    during gestation . IGF 2 exerts its effects by binding to the Insulin like growth factor 1 receptor IGF 1 receptor . IGF2 may also bind to the Insulin like growth factor 2 receptor IGF 2 receptor also ...PBB geneid 3481 Infobox protein family Symbol IGF2 C Name Insulin like growth factor II E peptide image ... OPM protein CAZy CDD Insulin like growth factor 2 IGF 2 is one of three protein hormone s that share ... Insulin like growth factor 2 has been shown to Protein protein interaction interact with IGFBP3 ... S, Ackmann M, Zapf J, Blum W, Braulke T year 2001 month Dec. title Transferrin binds insulin like growth factors and affects binding properties of insulin like growth factor binding protein 3 journal ... S M authorlink coauthors Baxter R C year 1998 month Mar. title Insulin like growth factor IGF binding ... binding of insulin like growth factor binding protein 3 journal J. Biol. Chem. volume 273 issue 5 pages ... . ref name pmid11749962 See also Insulin like growth factor 2 receptor Insulin like growth factor II IRES References reflist External links MeshName Insulin Like Growth Factor II Further reading refbegin 2 PBB Further reading citations cite journal author O Dell SD, Day IN title Insulin like growth .... title Insulin like growth factor I receptor signal transduction at the interface between physiology ... CA title The insulin like growth factor insulin system in epithelial ovarian cancer. journal Front ... AW, Duan C, Bern HA title Insulin like growth factor signaling in fish. journal Int. Rev. Cytol ... DEFAULTSORT Insulin Like Growth Factor 2 Category Peptide hormones Category Growth factors es Factor ... believed to be secreted by the liver and to circulate in the blood. It has growth regulating, insulin like and mitogenic activities. The growth factor has a major, but not absolute, dependence on somatotropin. It is believed to be a major fetal growth factor in contrast to IGF 1 Insulin like growth factor 1 , which is a major growth factor in adults . ref http www.ncbi.nlm.nih.gov mesh 68007335 ref ...   more details



  1. Insulin-like growth factor 2 receptor

    A, Francke U title Chromosomal mapping of the gene for the type II insulin like growth factor receptor ... is a multifunctional protein receptor biochemistry receptor that binds insulin like growth factor 2 ... Insulin like growth factor 2 receptor has been shown to Protein protein interaction interact with M6PRBP1 ... O Dell SD, Day IN title Insulin like growth factor II IGF II journal Int. J. Biochem. Cell Biol ... author Hawkes C, Kar S title The insulin like growth factor II mannose 6 phosphate receptor structure ... cite journal author Zhou J, Bondy C title Insulin like growth factor II and its binding proteins ... Insulin like growth factor II receptor as a multifunctional binding protein journal Nature volume 329 ... 6 phosphate insulin like growth factor II receptor locus in human hepatocellular tumors journal ... Siemsen C, Waheed A, et al. title Localization of the insulin like growth factor II binding site to amino acids 1508 1566 in repeat 11 of the mannose 6 phosphate insulin like growth factor II receptor ... Ishiwata T, Bergmann U, Kornmann M, et al. title Altered expression of insulin like growth factor II ... 6 Phosphate Insulin like Growth Factor II Receptor Targets the Urokinase Receptor to Lysosomes ... cation dependent mannose 6 phosphate receptor In the fields of biochemistry and cell biology , the insulin like growth factor 2 receptor IGF2R , also called the cation independent mannose 6 phosphate ... M title Expression of insulin like growth factors I and II and their receptor mRNAs in primary ... Identification and cloning of a connective tissue growth factor like cDNA from human osteoblasts encoding ... Like Growth Factor II Receptor PDB Gallery geneid 3482 Clusters of differentiation Growth factor receptors ... doi 10.1038 ng1295 447 cite journal author Ilvesm ki V, Blum WF, Voutilainen R title Insulin like growth factor binding proteins in the human adrenal gland journal Mol. Cell. Endocrinol. volume 97 ... pnas.160251397 url ref See also Cluster of differentiation IGF 1 Receptor Mannose 6 phosphate receptor ...   more details



  1. Growth factor-like domain

    Pfam box Symbol APP CU bd Name Amyloid precursor N terminal image 1mwp gfld.png width 200 caption The GFLD region of amyloid precursor protein Pfam PF02177 InterPro IPR008154 SMART SM00006 PROSITE SCOP 1mwp TCDB PDB PDB2 1mwp , PDB2 1owt , PDB2 2fjz , PDB2 2fk1 , PDB2 2fk2 , PDB2 2fk3 , PDB2 2fkl , PDB2 2fma A growth factor like domain GFLD is a protein domain structurally related to epidermal growth factor , which has a high binding affinity for the epidermal growth factor receptor . As structural domains within larger proteins, GFLD regions commonly bind calcium ion s. A subtype present in the N terminus N terminal region of the amyloid precursor protein is a member of the heparin binding class of GFLDs and may itself have growth factor function, particularly in promoting neuron al development. References Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, Galatis D, Hesse L, Multhaup G, Beyreuther K, Masters CL, Parker MW. 1999 . Crystal structure of the N terminal, growth factor like domain of Alzheimer amyloid precursor protein. Nat Struct Biol 6 4 327 31. protein stub Category Protein domains ...   more details



  1. Heparin-binding EGF-like growth factor

    binding epidermal growth factor like growth factor increases peripheral glucose disposal and insulin ...PBB geneid 1839 Heparin binding EGF like growth factor HB EGF is a member of the epidermal growth factor ... growth factor journal Cytokine Growth Factor Rev. volume 15 issue 1 pages 13 9 year 2004 month February ... E, Klagsbrun M, Greenberg DA title Heparin binding epidermal growth factor like growth factor hypoxia ... Raab G, Klagsbrun M title Heparin binding EGF like growth factor journal Biochim. Biophys. Acta ... M, Andrews GK, Dey SK title Heparin binding EGF like growth factor gene is induced in the mouse ... 1071 83 year 1994 month May pmid 8026321 doi ref Interactions Heparin binding EGF like growth factor ... is a specific receptor for heparin binding EGF like growth factor that mediates cell migration journal ..., Kawarabayashi T, Mekada E title Heparin binding epidermal growth factor like growth factor as a novel ... MT, Wakefield D title Proliferative effects of heparin binding epidermal growth factor like ... growth factor like growth factor signaling in flow induced arterial remodeling journal Circ ... S, Hashimoto K title Heparin binding EGF like growth factor accelerates keratinocyte migration and skin ... of heparin binding EGF like growth factor in wound fluid as a response to injury journal Proc. Natl ... M, Greenberg DA title Heparin binding epidermal growth factor like growth factor hypoxia inducible ... A, Das SK, Dey SK, Fazleabas AT title Heparin binding EGF like growth factor modulation by antiprogestin ... IO, Zhang HY, Yang J, Radulescu A, Zhou Y, Besner GE title Heparin binding EGF like growth factor ... EGF like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein ... of the heparin binding epidermal growth factor like growth factor gene in vascular endothelial ... to the epidermal growth factor EGF like domain of human heparin binding EGF like growth factor diphtheria ... K, Higashiyama S, Asada H, et al. title Heparin binding epidermal growth factor like growth factor ...   more details



  1. Fibroblast growth factor receptor 1

    PBB geneid 2260 Fibroblast growth factor receptor 1 FGFR1 , also known as basic fibroblast growth factor receptor 1 , fms related tyrosine kinase 2 Pfeiffer syndrome , and cluster of differentiation CD 331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor ... growth factor receptor 1 fms related tyrosine kinase 2, Pfeiffer syndrome url http www.ncbi.nlm.nih.gov ... Fibroblast growth factor receptor 1 has been shown to Protein protein interaction interact with GRB14 ... growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor ... and function of vertebrate fibroblast growth factor receptor 1 journal Int. J. Dev. Biol. volume ... form of human basic fibroblast growth factor receptor deduced from its cDNA journal Biochem. Biophys ... Targets on Fibroblast Growth Factor and Nerve Growth Factor Receptors journal Mol. Cell. Biol. volume ... motif on fibroblast growth factor receptor mediates direct association and activation of SNT ... title Expression and biological activity of mouse fibroblast growth factor 9 journal J. Biol. Chem ... Cytokine Growth Factor Rev. volume 16 issue 2 pages 187 203 year 2005 pmid 15863034 doi 10.1016 j.cytogfr.2005.03.001 ... factor receptor 1 on the Atlas of Genetics and Cytogenetics in Oncology and Haematology Atlas of Genetics ... 291X 90 90384 Y url ref Function The protein encoded by this gene is a member of the fibroblast growth factor receptor FGFR family, where amino acid sequence is highly conserved between members and throughout ... immunoglobulin like domains, a single hydrophobic membrane spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factor s, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors ... in olfactory bulb and palate morphogenesis journal Hum. Mutat. volume 28 issue 1 pages 97 8 year 2007 ...   more details



  1. Teratocarcinoma-derived growth factor 1

    Orphan date February 2009 PBB geneid 6997 Teratocarcinoma derived growth factor 1 is a protein that in humans is encoded by the TDGF1 gene . ref name pmid1882841 cite journal author Dono R, Montuori N, Rocchi M, De Ponti Zilli L, Ciccodicola A, Persico MG title Isolation and characterization of the CRIPTO ... cite web title Entrez Gene TDGF1 teratocarcinoma derived growth factor 1 url http www.ncbi.nlm.nih.gov ... Saccone S, Rapisarda A, Motta S, et al. title Regional localization of the human EGF like growth factor CRIPTO gene TDGF 1 to chromosome 3p21. journal Hum. Genet. volume 95 issue 2 pages 229 30 year ..., Viglietto G, Rocchi M, Persico MG title Assignment of human teratocarcinoma derived growth factor ... cite journal author Salomon DS, Bianco C, De Santis M title Cripto a novel epidermal growth factor ... 1 pages 61 70 year 1999 pmid 10070255 doi 10.1002 SICI 1521 1878 199901 21 1 61 AID BIES8 3.0.CO 2 H cite journal author Adamson ED, Minchiotti G, Salomon DS title Cripto a tumor growth factor and more .... title Identification and biological characterization of an epidermal growth factor related protein cripto 1. journal J. Biol. Chem. volume 269 issue 25 pages 17320 8 year 1994 pmid 8006041 doi cite journal author Friess H, Yamanaka Y, B chler M, et al. title Cripto, a member of the epidermal growth factor family, is over expressed in human pancreatic cancer and chronic pancreatitis. journal Int ... of transforming growth factor alpha, amphiregulin and CRIPTO in human normal and malignant breast tissues. journal Int. J. Cancer volume 65 issue 1 pages 51 6 year 1996 pmid 8543395 doi 10.1002 SICI 1097 0215 19960103 65 1 51 AID IJC9 3.0.CO 2 0 cite journal author Kannan S, De Santis M, Lohmeyer ... 1. journal Dev. Biol. volume 196 issue 2 pages 237 47 year 1998 pmid 9576836 doi 10.1006 dbio.1998.8862 ... author Ebert AD, Wechselberger C, Frank S, et al. title Cripto 1 induces phosphatidylinositol 3 kinase ... author Bianco C, Adkins HB, Wechselberger C, et al. title Cripto 1 activates nodal and ALK4 dependent ...   more details



  1. Growth factor

    A growth factor is a naturally occurring substance capable of stimulating cellular growth , ref DorlandsDict three 000038554 growth factor ref proliferation and cellular differentiation . Usually it is a protein or a steroid hormone . Growth factors are important for regulating a variety of cellular processes. Growth factors typically act as signaling molecules between cells. Examples are cytokine ... differentiation, while fibroblast growth factor s and vascular endothelial growth factor s stimulate blood vessel differentiation angiogenesis . Growth factors versus cytokines Growth factor is sometimes ... development and in the mature organism. While growth factor implies a positive effect on cell division ... growth factor proteins tend to occur as members of larger families of structurally and evolution arily ... derived neurotrophic factor BDNF Epidermal growth factor EGF Erythropoietin EPO Fibroblast growth ... CSF Granulocyte macrophage colony stimulating factor GM CSF Growth differentiation factor 9 GDF9 Hepatocyte growth factor HGF Hepatoma derived growth factor HDGF Insulin like growth factor IGF Migration stimulating factor Myostatin GDF 8 Nerve growth factor NGF and other neurotrophins Platelet derived growth factor PDGF Thrombopoietin TPO Transforming growth factor alpha TGF Transforming growth factor beta TGF Tumor necrosis factor alpha TNF Vascular endothelial growth factor VEGF Wnt Signaling Pathway placental growth factor PlGF Foetal Bovine Somatotrophin FBS IL 1 Cofactor for IL 3 and IL 6. Activates T cells. IL 2 T cell growth factor. Stimulates IL 1 synthesis. Activates B cells and NK cells. IL 3 Stimulates production of all non lymphoid cells. IL 4 Growth factor for activated .... IL 6 Stimulates Ig synthesis. Growth factor for plasma cells. IL 7 Growth factor for pre B ... Human Genome Organisation Growth factor receptor Mitogen References reflist External links ... Category Growth factors Category Immune system ar ca Factor de creixement cs R stov faktor ...   more details



  1. Relaxin/insulin-like family peptide receptor 1

    PBB geneid 59350 Relaxin insulin like family peptide receptor 1 , also known as RXFP1 , is a human G protein coupled receptor . ref name entrez cite web title Entrez Gene RXFP1 relaxin insulin like family peptide receptor 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 59350 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text See also Relaxin receptor References reflist External links cite web url http www.iuphar db.org GPCR ReceptorDisplayForward?receptorID 3022 title Relaxin Family Peptide Receptors RXFP1 accessdate author authorlink coauthors date format work IUPHAR Database of Receptors and Ion Channels publisher International Union of Basic and Clinical Pharmacology pages language archiveurl archivedate quote Further reading refbegin 2 PBB Further reading citations cite journal author Bathgate RA, Ivell R, Sanborn BM, et al. title Receptors for relaxin family peptides journal Ann. N. Y. Acad. Sci. volume 1041 issue pages 61 76 year 2005 pmid 15956688 doi 10.1196 annals.1282.010 cite journal author Bathgate RA, Ivell R, Sanborn ..., Kuei C, et al. title Relaxin 3 insulin like peptide 5 chimeric peptide, a selective ligand for G protein ... for relaxin family peptides journal Pharmacol. Rev. volume 58 issue 1 pages 7 31 year 2006 ... journal Reprod. Biol. Endocrinol. volume 1 issue pages 114 year 2004 pmid 14633277 doi 10.1186 1477 7827 1 114 pmc 293425 cite journal author Ota T, Suzuki Y, Nishikawa T, et al. title Complete sequencing and characterization of 21,243 full length human cDNAs journal Nat. Genet. volume 36 issue 1 ... 7 journal Mol. Pharmacol. volume 67 issue 1 pages 231 40 year 2005 pmid 15465925 doi 10.1124 ... B llesbach EE, Schwabe C title The trap like relaxin binding site of the leucine rich G protein ... relaxin receptor increases the transcription of IGFBP 1 and prolactin in human decidual and endometrial ...   more details



  1. Fibroblast growth factor receptor

    B. et al. title N glycosylation of fibroblast growth factor receptor 1 regulates ligand and heparan ...The fibroblast growth factor receptors are, as their name implies, Receptor biochemistry receptors that bind to members of the fibroblast growth factor family of proteins. Some of these receptors are involved ... . Structure The fibroblast growth factor receptors consist of a cellular ligand domain composed of three immunoglobulin like domains, a single transmembrane helix domain, and an intracellular domain with tyrosine kinase activity. These receptors bind fibroblast growth factor s, members of the largest family of growth factor ligands, comprising 22 members. ref name ornitz cite journal author Ornitz DM. and Itoh, N. title Fibroblast growth factors journal Genome Biol. year 2001 volume 2 issue 3 ... splicing alternate splicing of four fibroblast growth factor receptor FGFR genes results in the production ..., et al. title Receptor Specificity of the Fibroblast Growth Factor Family journal JBC volume 271 issue ... Sleeman M, Fraser J. et al. title Identification of a new fibroblast growth factor receptor, FGFR5 journal ... to the tyrosine kinase superfamily FGFR1 to FGFR4 . Gene FGFR1 see also Fibroblast growth factor receptor 1 CD331 Gene FGFR2 see also Fibroblast growth factor receptor 2 CD332 Gene FGFR3 see also Fibroblast growth factor receptor 3 CD333 Gene FGFR4 see also Fibroblast growth factor receptor 4 CD334 ... www.sabiosciences.com pathway.php?sn FGF Signaling FGF signaling with refs Growth factor receptors Tyrosine kinases DEFAULTSORT Fibroblast Growth Factor Receptor Category Tyrosine kinase receptors ... Ig like domains D1 D3 , and thus belong to the immunoglobulin superfamily . ref name coutts cite journal author Coutts JC, and Gallagher JT. title Receptors for fibroblast growth factors journal ... ref The three immunoglobin Ig like domains D1, D2, and D3 present a stretch of acid ic amino acid .... Immunoglobulin like domains D2 and D3 are sufficient for FGF binding. Each receptor can be activated ...   more details



  1. Epidermal growth factor receptor

    Signalling by the type 1 insulin like growth factor receptor interplay with the epidermal growth factor ... for insulin like growth factor I receptor with distinct roles from Mdm2 in receptor ubiquitination ... geneid 1956 The epidermal growth factor receptor EGFR ErbB 1 HER1 in humans is the Cell membrane cell surface receptor biochemistry receptor for members of the epidermal growth factor family EGF family ... map of epidermal growth factor receptor signaling journal Mol. Syst. Biol. volume 1 issue 1 pages ... tyrosine phosphatase SHP 1 to the epidermal growth factor receptor and attenuation of receptor ... the epidermal growth factor receptor journal IUBMB Life volume 53 issue 1 pages 3 14 year ... Herbst RS title Review of epidermal growth factor receptor biology journal Int. J. Radiat. Oncol. Biol ... url ref The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily ... JCI32278 url ref Epidermal Growth Factor was discovered by Stanley Cohen biochemist Stanley Cohen ... or Medicine in 1986. Function EGFR epidermal growth factor receptor exists on the cell surface and is activated by binding of its specific ligand s, including epidermal growth factor and TGF alpha transforming growth factor TGF note, a full list of the ligands able to activate EGFR and other ... heterodimerization with other family members such as EGFR. Upon activation by its growth factor ligands ... pmid3494473 cite journal author Yosef Yarden and Joseph Schlessinger title Epidermal Growth Factor Induces Rapid, Reversible Aggregation of the Purified Epidermal Growth Factor Receptor journal Biochemistry ... MD title Autophosphorylation sites on the epidermal growth factor receptor journal Nature volume 311 ... skin mediated by transactivation of the epidermal growth factor receptor journal J Clin Invest. volume ... growth factor receptor underlying responsiveness of non small cell lung cancer to gefitinib ... growth factor antagonist that inhibits tumor cell growth journal J. Biol. Chem. volume 273 ...   more details



  1. Placental growth factor

    like domain of the vascular endothelial growth factor placenta growth factor receptor Flt 1 ... title Placental growth factor PlGF and its receptor Flt 1 VEGFR 1 novel therapeutic targets for angiogenic ... JY cite journal author Park JE title Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt 1 but not to Flk 1 ... author Ziche M title Placenta growth factor 1 is chemotactic, mitogenic, and angiogenic journal Lab ... structure of human placenta growth factor 1 PlGF 1 , an angiogenic protein, at 2.0 A resolution journal ... Mamluk R title Neuropilin 1 binds vascular endothelial growth factor 165, placenta growth factor 2, and heparin ...PBB geneid 5228 Placental growth factor is a protein that in humans is encoded by the PGF gene . ref name entrez cite web title Entrez Gene PGF placental growth factor, vascular endothelial growth factor ... mRNAs coding for the angiogenic factor, placenta growth factor PlGF , are transcribed from a single ... doi url issn ref Placental growth factor PGF is a member of the VEGF vascular endothelial growth ... Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation journal ... growth factor dependent and independent regulation of angiogenesis journal BMB Rep volume ... fms like tyrosine kinase 1 sFlt 1 soluble fms like tyrosine kinase 1, also known as soluble ... for the angiogenic factor, placenta growth factor PlGF , are transcribed from a single gene of chromosome ... N cite journal author Hauser S, Weich HA title A heparin binding form of placenta growth factor PlGF ... Mattei MG title Assignment of vascular endothelial growth factor VEGF and placenta growth factor ... Vuorela P title Expression of vascular endothelial growth factor and placenta growth factor in human ... first8 E cite journal author Cao Y title Placenta growth factor identification and characterization ... Y, Claesson Welsh L title Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase ...   more details



  1. Fibroblast growth factor

    Fibroblast growth factor image PDB 1nun EBI.jpg width caption crystal structure analysis of the fgf10 ... FGF10 all bind fibroblast growth factor receptor s FGFRs . FGF1 is also known as acidic , and FGF2 is also known as basic fibroblast growth factor . Members FGF11 , FGF12 , FGF13 , and FGF14 , also ... author Olsen SK, Garbi M. et al. title Fibroblast growth factor FGF homologous factors share structural ... JST.JSTAGE endocrj KR07E 002?from PubMed ref Receptors The mammalian fibroblast growth factor ... as it is capable of activating all 7 different FGFRs. In contrast, FGF7 keratinocyte growth factor ... or two heparan sulfate chains. History Fibroblast growth factor was found in pituitary extracts by Armelin ... cite journal author Gospodarowicz D title Localisation of a fibroblast growth factor and its effect ... growth factor FGF1 and basic fibroblast growth factor FGF2 . These proteins had a high degree ... al. title Nuclear activities of basic fibroblast growth factor potentiation of low serum growth mediated ... of heparin binding growth factors that they named HBGF 1 and HBGF 2, while a third group isolated ... of fibroblast growth factor receptors ref Promiscuous refers to the biochemistry and pharmacology ... journal author B ttcher RT, Niehrs C. title Fibroblast growth factor signaling during early vertebrate ... C.Z., Schutzman J.L. and Stern M.J. title Fibroblast growth factor signaling in Caenorhabditis elegans ... like structures. They thus promote angiogenesis , the growth of new blood vessel s from the pre ... growth factor VEGF or platelet derived growth factor PDGF . ref cite journal author Vlodavsky Cao R ... Growth Factor s KGF and KGF2, respectively stimulate the repair of injured skin and mucosal ... and functions of fibroblast growth factor 2 FGF 2 in hippocampal formation. Neuroscientist ... beta and 1 alpha and fibroblast growth factors journal J. Mol. Biol. volume 223 issue 2 pages 531 43 ... of human basic fibroblast growth factor journal Proc. Natl. Acad. Sci. U.S.A. volume 88 issue 8 pages ...   more details



  1. Epidermal growth factor

    16076471 doi 10.1016 j.atherosclerosis.2005.06.038 url ref Heparin binding EGF like growth factor HB EGF TGF alpha transforming growth factor TGF Amphiregulin AR Epiregulin EPR Epigen Betacellulin ...PBB geneid 1950 Epidermal growth factor or EGF is a growth factor that stimulates cell growth , cell growth proliferation , and Cellular differentiation differentiation by binding to its receptor Epidermal growth factor receptor EGFR . Human EGF is a 6045 dalton unit Da protein with 53 amino acid amino ... Carpenter G, Cohen S title Epidermal growth factor journal The Journal of Biological Chemistry volume ... of epidermal growth factor receptor biology journal International Journal of Radiation Oncology, Biology ... 2 doi 10.1177 026010600902000204 ref Biological Sources Epidermal growth factor can be found in human platelets, macrophages, urine, saliva, milk, and plasma. ref name isbn0 7216 0187 1 cite book ... by binding with high Affinity pharmacology affinity to epidermal growth factor receptor EGFR on the plasma ... KB, Loughlin SE, Morrison RS, Bradshaw RA, Knaver DJ, Cunningham DD title Epidermal growth factor ..., Ferns GA title The epidermal growth factor receptors and their family of ligands their putative role ... factor has been shown to Protein protein interaction interact with Epidermal growth factor receptor ... Role of the N terminus of epidermal growth factor in ErbB 2 ErbB 3 binding studied by phage display ... for the COOH terminal region of the epidermal growth factor EGF receptor in amphiregulin and EGF mitogenic ... of Epidermal Growth Factor EGF at the http www.hprd.org protein 00578 Human Protein Reference Database . MeshName Epidermal growth factor http www.ebi.ac.uk biomodels main static pages.do?page ModelMonth ... growth factor journal Cell Biol. Int. volume 19 issue 5 pages 413 30 year 1995 pmid 7640657 doi 10.1006 cbir.1995.1086 cite journal author Dvorak B title Epidermal growth factor and necrotizing ... doi 10.1016 j.clp.2004.03.015 cite journal author Howell WM title Epidermal growth factor gene ...   more details



  1. Transforming growth factor

    Transforming growth factor sometimes referred to as Tumor growth factor , or TGF is used to describe two classes of polypeptide growth factor s, TGF&alpha and TGF beta TGF&beta . The name Transforming Growth Factor is somewhat arbitrary, since the two classes of TGFs are not structurally or genetically related to one another, and they act through different receptor biochemistry receptor mechanism biology mechanisms . Furthermore, they do not always induce cellular transformation , and are not the only growth factors that induce cellular transformation. Types TGF&alpha is upregulated in some human cancer s. It is produced in macrophage s, brain cells, and keratinocyte s, and induces epithelium epithelial development. TGF beta TGF exists in three known subtypes in humans, TGF&beta 1, TGF&beta 2, and TGF&beta 3. These are upregulated in Marfan s syndrome ref name dysregmarfan Circulating transforming growth factor beta in Marfan syndrome. Matt P, Schoenhoff F, Habashi J, Holm T, Van Erp C, Loch D, Carlson OD, Griswold BF, Fu Q, De Backer J, Loeys B, Huso DL, McDonnell NB, Van Eyk JE, Dietz HC GenTAC Consortium. Circulation. 2009 Aug 11 120 6 526 32. Epub 2009 Jul 27. PMID 19635970 ref ref name popmarfan http sciencenow.sciencemag.org cgi content full 2008 625 3?etoc Inhibiting TGF to help Marfan ref and some human cancers, and play crucial roles in tissue regeneration , cell differentiation , embryonic development , and regulation of the immune system . Isoforms of transforming growth factor beta TGF 1 are also thought to be involved in the pathogenesis of pre eclampsia . TGF&beta ...?search TGF Tumor growth factor TGF citations http www.ihop net.org UniPub iHOP gs 125537.html ... MeshName Transforming Growth Factors Signaling proteins Category Growth factors Category Signal transduction cs Transformuj c r stov faktor de Transforming growth factor fr Facteur de croissance de ... in a specific cell culture system, rat kidney fibroblasts. Application of the transforming growth factors ...   more details



  1. Hepatocyte growth factor

    PBB geneid 3082 Hepatocyte growth factor scatter factor HGF SF is a paracrine cellular growth, motility and morphogen morphogenic factor . It is secreted by mesenchymal cell s and targets and acts primarily ... growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine ... SA title Identification of the hepatocyte growth factor receptor as the c met proto oncogene product ... science.1846706 url issn ref . Hepatocyte growth factor is secreted by mesenchymal cells and acts ... growth factor hepapoietin A scatter factor url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ... noedit ref ref name HahnPyun2011 cite pmid 21898720 noedit ref Interactions Hepatocyte growth factor ... Identification of the hepatocyte growth factor receptor as the c met proto oncogene product journal ... month Oct. title Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET ... author Michalopoulos GK, Zarnegar R title Hepatocyte Growth Factor journal Hepatology volume 15 issue 1 pages 149 54 year 1992 doi 10.1002 hep.1840150125 cite journal author Nakamura T title Structure and function of hepatocyte growth factor journal Prog. Growth Factor Res. volume 3 issue 1 pages ... Hepatocyte growth factor from diagnosis to clinical applications journal Clin. Chim. Acta volume ... Skibinski G title The role of hepatocyte growth factor c met interactions in the immune system journal ... 10.1172 JCI20530 pmc 297008 cite journal author Hurle RA title Hepatocyte growth factor scatter factor ... 10.1042 BST0340414 refend PDB Gallery geneid 3082 See also growth factor hepatocyte growth factor receptor HGFR External links MeshName Hepatocyte growth factor http atlasgeneticsoncology.org Genes HGFID385ch7q21.html Hepatocyte growth factor on the Atlas of Genetics and Cytogenetics in Oncology and Haematology ... with growth factors and morphogens editor Iozzo, M, V. year 2000 publisher Marcel Dekker ... MA title Keratinocyte and hepatocyte growth factors in the lung roles in lung development, inflammation ...   more details



  1. Basic fibroblast growth factor

    PBB geneid 2247 Basic fibroblast growth factor , also known as bFGF , FGF2 or FGF , ref http www.copewithcytokines.de ... growth factor family. ref name pmid9925931 cite journal author Kim HS title Assignment1 of the human basic fibroblast growth factor gene FGF2 to chromosome 4 band q26 by radiation hybrid mapping ... url ref Function In normal tissue, basic fibroblast growth factor is present in basement membrane ... in the form of an increased proliferation after binding to fibroblast growth factor receptor .... title Cardiac specific overexpression of fibroblast growth factor 2 protects against myocardial dysfunction ... embryonic stem cell culture medium the growth factor is necessary for the cells to remain in an undifferentiated ... Basic fibroblast growth factor has been shown to Protein protein interaction interact with casein ... year 2001 month November title Fibroblast growth factor 2 interacts with free ribosomal protein S19 ... growth factor Growth factor Proteases in angiogenesis Receptor biochemistry Signal transduction ... D, Vacca A, Rusnati M, Presta M title The discovery of basic fibroblast growth factor fibroblast growth factor 2 and its role in haematological malignancies. journal Cytokine Growth Factor Rev ... chain reaction shows expression of basic fibroblast growth factor transcripts in human granulosa and cumulus ... dimensional structure of human basic fibroblast growth factor. journal Proc. Natl. Acad. Sci. U.S.A. ... growth factor gene expression. journal Ann. N. Y. Acad. Sci. volume 638 issue pages 109 26 year 1992 ... PJ, Sprang SR title Three dimensional structure of human basic fibroblast growth factor, a structural ... growth factor gene FGFB is assigned to chromosome 4q25. journal Cytogenet. Cell Genet. volume ... M, Galland F, Simonetti J, et al. title The human basic fibroblast growth factor gene is located ... Amino terminal sequence of a large form of basic fibroblast growth factor isolated from human benign ... M, Igarashi K title Cloning and expression of cDNA encoding human basic fibroblast growth factor ...   more details



  1. Growth factor receptor

    A growth factor receptor is a Receptor biochemistry receptor which binds to growth factor . ref MeshName Growth Factor Receptors ref These receptors may use the JAK STAT signaling pathway JAK STAT , MAP kinase , and Phosphoinositide 3 kinase PI3 kinase pathways. ref name HoffbrandMoss2006 cite book author1 A. V. Hoffbrand author2 P. A. H. Moss author3 J. E. Pettit title Essential haematology url http books.google.com books?id IFFL 1YNy oC&pg PA6 accessdate 28 November 2010 year 2006 publisher Wiley Blackwell isbn 9781405136495 pages 6 ref References reflist Growth factor receptors Category Receptors biochem stub ...   more details



  1. Growth differentiation factor

    of left right patterning in mice by growth differentiation factor 1 journal Nat Genet volume 24 issue ...Growth differentiation factors GDFs are a subfamily of proteins belonging to the transforming growth factor beta superfamily that have functions predominantly in development. ref name herpin cite journal author Herpin A, Lelong C, Favrel P title Transforming growth factor beta related proteins an ancestral ... O Keeffe G, Dockery P, Sullivan A title Effects of growth differentiation factor 5 on the survival ... author Buxton P, Edwards C, Archer C, Francis West P title Growth differentiation factor 5 GDF 5 and skeletal development journal J Bone Joint Surg Am volume 83 A Suppl 1 issue Pt 1 pages S23 30 year ..., Swahn M, Hsueh A, Hovatta O title Growth differentiation factor 9 promotes the growth, development ... E, Ib ez C title Growth differentiation factor 11 signals through the transforming growth factor ..., Hsiao E, McGrath S, Esquela A, Koniaris L title Growth differentiation factor 15 macrophage inhibitory ... S, Huynh T, Lee S title Characterization of growth differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury journal Mol Cell Biol volume ... 1 expression independently of Hfe, transferrin receptor 2 Tfr2 , and IL 6 journal Proc Natl Acad ... issue 1 pages 111 9 year 1999 pmid 10199971 doi 10.1007 s004410051272 ref GDF6 interacts with bone morphogenetic ... 6 43 pmc 1609107 ref GDF8 is now officially known as myostatin and controls the growth of muscle ... pages 83 90 author McPherron AC, Lawler AM, Lee SJ ref GDF9 , like GDF3, lacks one cysteine relative ... issue 1 pages 316 21 year 2002 pmid 11788667 doi 10.1210 jc.87.1.316 ref GDF10 is closely related to Bone ... author Cunningham N, Jenkins N, Gilbert D, Copeland N, Reddi A, Lee S title Growth differentiation factor 10 a new member of the transforming growth factor beta superfamily related to bone morphogenetic protein 3 journal Growth Factors volume 12 issue 2 pages 99 109 year 1995 pmid 8679252 doi 10.3109 ...   more details



  1. Vascular endothelial growth factor

    growth factor in cancer journal Cytokine Growth Factor Rev. volume 16 issue 1 pages 77 89 year 2005 ..., Agrawal DK title Immunomodulatory role of vascular endothelial growth factor and angiopoietin 1 in airway ...Vascular endothelial growth factor VEGF is a signal protein produced by cells that stimulates vasculogenesis ... diseases. VEGF is a sub family of growth factors , to be specific, the platelet derived growth factor ... The most important member is VEGF A . Other members are Placenta growth factor PlGF , VEGF B , VEGF ... M. last4 Cross first4 Michael J. title Vascular endothelial growth factor receptor 2 Structure, function ... of vascular endothelial growth factor D in angiosarcoma patients journal British Journal of Dermatology ... Growth Factor in Kidney Leads to Progressive Impairment of Glomerular Functions journal Journal ... decrease vascular endothelial growth factor VEGF production by human luteinized granulosa cells ... links MeshName Vascular Endothelial Growth Factors Proteopedia Vascular Endothelial Growth Factor the Vascular Endothelial Growth Factor Structure in Interactive 3D Further reading refbegin 2 ... of Visual Experience on Vascular Endothelial Growth Factor Expression during the Postnatal Development ... of vascular endothelial growth factor in angiogenesis journal Acta Haematol. volume 106 issue ... Ria R title Vascular endothelial growth factor and its receptors in multiple myeloma journal Leukemia ... first5 F last6 Ribatti first6 D cite journal author Caldwell RB title Vascular endothelial growth factor ... factor vascular endothelial growth factor in angiogenesis a historical review journal Br. J. Haematol ... Signal transduction via vascular endothelial growth factor VEGF receptors and their roles in atherogenesis ... Vascular endothelial growth factor in amyotrophic lateral sclerosis and other neurodegenerative diseases ... strategies of vascular endothelial growth factor in renal cell carcinoma journal Clin. Cancer ... Depolymerized hyaluronan induces vascular endothelial growth factor, a negative regulator of developmental ...   more details



  1. Nerve growth factor

    PBB geneid 4803 Nerve growth factor NGF is a small secreted protein that is important for the growth ... ref It is perhaps the prototypical growth factor , in that it is one of the first to be described. While nerve growth factor refers to a single factor, ref MeshName Nerve Growth Factor ref nerve ... factor causes axonal growth. Studies have shown that it causes axonal branching and a bit of elongation ... called growth factor receptor bound protein 2 Grb2 along with a docking protein called Grb2 associated ... of nerve growth factor dependent sympathetic neurons journal J. Neurosci. volume 18 ... of nerve growth factor journal Nature volume 354 issue 6352 pages 411 4 year 1991 month December ... nerve growth factor family of structurally conserved proteins. History Rita Levi Montalcini and Stanley ... to reduce neural degeneration. ref Tuszynski M., Blesch A. 2004 . Nerve growth factor from animal models ... 46021 4 url issn chapter Expression of nerve growth factor in the airways and its possible role in asthma ... growth factor and other trophic factors in brain inflammation series Progress in Brain Research ... pmid 14699974 doi 10.1016 S0079 6123 03 46023 8 url issn chapter Nerve growth factor and wound healing ... s disease . ref cite journal author Counts S, Mufson E title The role of nerve growth factor receptors ... growth factor NGF has high levels when people first fall in love , but these levels return to as they were ..., Geroldi D title Raised plasma nerve growth factor levels associated with early stage romantic love ... of eternal life? Science News The Independent Interactions Nerve growth factor has been shown to Protein ... journal author Wiesmann C, Ultsch MH, Bass SH, de Vos AM title Crystal structure of nerve growth factor ... growth factor receptor . ref name pmid11729324 ref name pmid14985763 See also Protein targeting Nervous System VGF VGF Nerve Growth Factor inducible , a protein whose expression is induced by NGF neurotrophin growth factor brain derived neurotrophic factor neurotrophin 3 neurotrophin 4 nerve growth ...   more details




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