wiktionary Receptor may refer to Cellular Sensory receptor , in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse Molecular Receptor biochemistry , in biochemistry, a protein molecule that receives and responds to a neurotransmitter, or other substance Special cases of receptors in biochemistry Cell surface receptor , a receptor on the outer surface of a cell membrane, that takes part in communication between the cell and the outside world Nuclear receptor , a receptor found within cells that is responsible for sensing steroid and thyroid hormones and certain other molecules Immune receptor , a receptor that occurs on the surface of immunocytes and binds to antigens Telecommunication Receiver radio , a device for the reception of electromagnetic signals disambig ar ca Receptor fr R cepteur id Reseptor it Recettore lt Receptorius nl Receptor oc Receptor ro Receptor ru sl Receptor fi Reseptori zh ... more details
A somatomedin receptor is a receptor which binds somatomedin . There are two types Insulin like growth factor 1 receptorInsulin like growth factor 2 receptor External links MeshName Somatomedin Receptor Growth factor receptors Category Receptors biochem stub ... more details
The Insulin Index is a measure used to quantify the typical insulin response to various foods. The index ..., the Insulin Index is based upon blood insulin levels. This measure can be more useful than either ... an insulin response despite there being no carbohydrate s present, and some foods cause a disproportionate insulin response relative to their carbohydrate load. Holt et al. have noted that the glucose and insulin scores of most foods are highly correlated, ref name Cure for Diabetes http books.google.it books?id 2aTatu9P XwC&pg PT144&dq insulin index&hl it&ei DBdZTYGSCMLIswblqOWLAg&sa X&oi book result&ct result&resnum 1&ved 0CCkQ6AEwAA v onepage&q insulin 20index&f false There Is a Cure for Diabetes ... carbohydrates elicit insulin responses that were disproportionately higher than their glycemic responses. They also conclude that insulin indices may be useful for dietary management and avoidance of non insulin dependent diabetes mellitus and hyperlipidemia. Explanation of Index The insulin index shows how much insulin is present in people s blood as a result of a particular food, the glucose ... and insulin scores were determined by feeding 1000 kilojoules 239 kilocalories of the food to the participants and recording the area under the glucose insulin curve for 120 minutes then dividing by the area under the glucose insulin curve for white bread. The result being that all scores are relative ... date 1996.11.21 title An insulin index of foods the insulin demand generated by 1000 kJ portions of common ... 2011 06 02 laysummary http www.mendosa.com insulin index.htm laysource Insulin Index By David Mendosa laydate 2009.10.14 ref insulin ref name Holt1997 and satiety scores ref Cite journal last1 ... laydate 2005.01.10 year 1995 ref Food Food Type Glucose score Insulin score Satiety score All ... Food Food Type Glucose score Insulin score Satiety score Reflist group n See also Glycemic index Glycemic load Insulin oscillations References Reflist M kel inen, H, The effect of glucan on the glycemic ... more details
orphan date February 2009 Oralin is a premeal oral insulin currently under investigation. The medicine is administered as an oral spray. It is currently evaluated in comparison with oral hypoglycemic agent s, mostly in patients with type 2 diabetes type 2 Diabetes mellitus DM . The clinical data appears promising, but further evaluation of its efficacy in type 1 diabetes type 1 DM is needed. ref cite book title Nelson Textbook of Pediatrics by Robert M Kliegman, Richard E Behrman, Hal B Jenson, Bonita F Stanton ref References reflist 3 External links Category Pharmacology Oralin gastrointestinal drug stub ... more details
PDR.0b013e3181425869 ref IGF Receptors The IGF s are known to bind the IGF 1 receptor , the insulinreceptor , the insulin like growth factor 2 receptor IGF 2 receptor , the insulin related receptor and possibly other receptors. The IGF 1 receptor is the physiologic receptor IGF 1 binds to it at significantly higher affinity than it binds the insulinreceptor. Like the insulinreceptor, the IGF 1 receptor is a receptor tyrosine kinase meaning the receptor signals by causing the addition of a phosphate molecule on particular tyrosines. The IGF 2 receptor only binds IGF 2 and acts as a clearance receptor it activates no intracellular signalling pathways, functioning only as an IGF 2 sequestering ... it is capable of activating the insulinreceptor , it can also complement for the effects of insulin . IGF Binding Proteins IGF 1 and IGF 2 are regulated by a family of proteins known as the Insulin ... 2001 title Regulation of DAF 2 receptor signaling by human insulin and ins 1, a member of the unusually ...Image 3GF1 Insulin Like Growth Factor Nmr 10 01.png thumb ILGF The insulin like growth factors IGFs are protein s with high Homology biology sequence similarity to insulin . IGFs are part of a complex ... often referred to as the IGF axis consists of two cell surface receptor s IGF1R and IGF2R , two ligand s IGF 1 and IGF 2 , a family of six high affinity Insulin like growth factor binding protein IGF binding proteins IGFBP 1 6 , as well as associated Insulin like growth factor binding protein IGFBP ... referred to as the Growth Hormone IGF1 Axis. Insulin like growth factor 1 IGF 1 is mainly secreted ... death apoptosis . Insulin like growth factor 2 IGF 2 is thought to be a primary growth factor required ... LL last3 Rogers first3 I last4 Holly first4 JM last5 Alspac Study first5 Team title Association of Insulin like Growth Factor I and Insulin like Growth Factor Binding Protein 3 with Intelligence Quotient ... tissue types express the IGF 1 receptor , IGF 1 s effects are diverse. It acts as a neurotrophic factor ... more details
J.K, Yee, Sly W.S, et al. title Insulin like growth factor receptor expression and function in human ...Expert subject Medicine date November 2008 Insulin potentiation therapy IPT is an alternative cancer treatment using insulin to administer low dose chemotherapy . ref name pmid3526099 cite journal author Ayre SG, Perez Garcia y Bellon D, Perez Garcia D title Insulin potentiation therapy a new concept ... of cancer cells, specifically the secretion of insulin and insulin like growth factor, and the interaction of these biochemicals with their specific receptors. By using insulin in conjunction with chemotherapy ... to understand the mechanisms of IPT, which relies upon insulin, the most integral component of IPT ... system. Differentiation between cancer and normal cells Ref improve section date January 2010 Insulin biologically differentiates cancer cells from normal cells based on insulinreceptor concentration. The body s own hormone insulin is produced in the pancreas and is responsible for transporting nutrients from the blood into the cells. Insulin docks onto the cell and opens it so that these nutrients can enter. Insulin can serve to distinguish and differentiate cancer cells from healthy cells in several ways. Insulin is produced in the pancreas, one of whose many functions is the regulation of blood glucose levels. Insulin activates a glucose transport protein within all cells whether they be cancerous ... have considerably more insulin receptors, i.e. docking points for insulin, than normal cells. ref ... 3 9812416 1 7 pages 44 ref Cancer cells have developed the ability to produce insulin and insulin like ... journal author Zapf J., Froesch E.R. title Insulin like growth factors somatomedins structure, secretion ... D.H., Osborne C.K. title Pertubation by insulin of human breast cancer cell kinetics journal Cancer ... of insulin as a hormonal factor in breast cancer. In Pike M.C., Siiteri P.K., Welsh C.W.,eds. Hormones ... A.A., Cullen K.J. title Paracrine autocrine regulation of breast cancer by the insulin like growth ... more details
Z is a regulatory sequence for the insulin gene ref Melloul et al., Diabetologica, 45, 309 326, year 2002. Regulation of insulin gene transcription ref References reflist Insulin gene regulatory sequences Category Regulatory sequences biochemistry stub ... more details
A2 is a regulatory sequence for the insulin gene ref Melloul et al., Diabetologica, 45, 309 326, year 2002. Regulation of insulin gene transcription ref References reflist Insulin gene regulatory sequences Category Regulatory sequences biochemistry stub ... more details
protein Name relaxin insulin like family peptide receptor 1 caption image width HGNCid 19718 Symbol RXFP1 AltSymbols LGR7 EntrezGene 59350 OMIM 606654 RefSeq NM 021634 UniProt Q9HBX9 PDB ECnumber Chromosome 4 Arm q Band 31.3 LocusSupplementaryData protein Name relaxin insulin like family peptide receptor 2 caption image width HGNCid 17318 Symbol RXFP2 AltSymbols LGR8, GREAT, GPR106, INSL3R EntrezGene 122042 OMIM 606655 RefSeq NM 130806 UniProt Q8WXD0 PDB ECnumber Chromosome 13 Arm q Band 12.3 LocusSupplementaryData protein Name relaxin insulin like family peptide receptor 3 caption image width HGNCid 24883 Symbol RXFP3 AltSymbols RLN3R1, SALPR, GPCR135 EntrezGene 51289 OMIM 609445 RefSeq NM 016568 UniProt Q9NSD7 PDB ECnumber Chromosome 5 Arm p Band 15.1 LocusSupplementaryData p14 protein Name relaxin insulin like family peptide receptor 4 caption image width HGNCid 14666 Symbol RXFP4 AltSymbols GPR100, GPCR142, RLN3R2 EntrezGene 339403 OMIM 609043 RefSeq NM 181885 UniProt Q8TDU9 PDB ECnumber Chromosome 1 Arm q Band 22 LocusSupplementaryData The relaxin receptor s are a subclass of four closely related G protein coupled receptors that bind relaxin peptide hormones. ref name pmid16507880 cite journal author Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ title International Union of Pharmacology LVII recommendations for the nomenclature of receptors for relaxin family peptides journal Pharmacol. Rev. volume 58 issue 1 pages 7 31 year 2006 pmid 16507880 doi 10.1124 pr.58.1.9 ref ref name pmid17293890 cite journal author Halls ML, van der Westhuizen ET, Bathgate RA, Summers RJ title Relaxin family peptide receptors former orphans reunite with their parent ligands to activate ..., their endogenous peptide hormones, and what down stream enzymes are activated or inhibited by the receptor. class wikitable receptor gene ligands activates inhibits gene RXFP1 Relaxin 1, Relaxin ... sr Relaksinski receptor ... more details
A hormone receptor is a molecule that can bind to a specific hormone . Receptors for peptide hormones tend to be found on the cell membrane plasma membrane of cells, whereas receptors for lipophillicity lipid soluble hormones are usually found within the cytoplasm . Upon hormone binding, the receptor can initiate multiple signaling pathways which ultimately lead to changes in the behaviour of the target cells. Peptide hormone receptors Many hormones are composed of peptides polypeptides , e.g. thyroid stimulating hormone , follicle stimulating hormone , leutinizing hormone and insulin . These molecules are not lipid soluble and therefore cannot molecular diffusion diffuse through cell membranes. Consequently, receptors for peptide hormones are located on the plasma membrane. Peptide hormone receptors are often transmembrane protein s. They are also called G protein coupled receptor s, sensory receptor s or ionotropic receptor s. These receptors generally function via intracellular second messengers , including cyclic AMP cAMP , inositol 1,4,5 trisphosphate Inositol triphosphate IP3 and the Calcium signaling calcium Ca sup 2 sup calmodulin system. Lipid soluble hormone receptors Steroid hormone receptor s and related receptors are generally soluble proteins that function through gene activation. Their response elements are DNA sequences promoters that are bound by the complex of the steroid bound to its receptor. The receptors themselves are zinc finger proteins. ref http users.rcn.com jkimball.ma.ultranet BiologyPages S SteroidREs.html Steroid Hormone Receptors and their Response Elements ref These receptors include those for Glucocorticoid glucocorticoids , estrogen s, androgen s, thyroid hormone T3 , calcitriol the active form of vitamin D , and the retinoid s vitamin A . References reflist Neuropeptide receptors Transcription factors g2 membrane protein stub receptor ... fr R cepteur d hormone it Recettori ormonali sr Hormonski receptor ... more details
A5 is a regulatory sequence for the insulin gene ref Melloul et al., Diabetologica, 45, 309 326, year 2002. Regulation of insulin gene transcription ref References reflist Insulin gene regulatory sequences Category Regulatory sequences biochemistry stub es Caja A5 ... more details
A3 is a regulatory sequence for the insulin gene ref Melloul et al., Diabetologica, 45, 309 326, year 2002. Regulation of insulin gene transcription ref References reflist Insulin gene regulatory sequences Category Regulatory sequences biochemistry stub es Caja A3 ... more details
. This family of receptors includes Erythropoietin receptor Erythropoietin InsulinreceptorInsulin Eph receptor s Insulin like growth factor 1 receptor various other growth factor receptor growth factor ...Other uses Receptor disambiguation Technical date May 2008 In the field of biochemistry , a receptor ... originating externally from the cell. Through binding to a receptor, these signals direct a cell ... are protein molecules, embedded in either the plasma membrane cell surface receptor s or the cytoplasm or cell nucleus nucleus nuclear receptor s of a cell, to which one or more specific kinds of signal transduction signaling molecules may attach. A molecule which binds attaches to a receptor is called ... , a hormone , a pharmaceutical drug, or a toxin. Numerous receptor types ... each type of receptor recognizes and binds only certain ligand shapes in analogy to a lock and key where the lock represents the receptor and the key, its ligand . Hence the selective binding of specific a ligand to its receptor activates or inhibits a specific biochemical pathway. Ligand binding stabilizes a certain receptor conformational change conformation the three dimensional shape of the receptor ... to some sort of cellular response. However, some ligands e.g. Receptor antagonist antagonists ... receptor.svg thumb right Transmembrane receptor E extracellular space I intracellular space P plasma ... categories peripheral membrane protein s transmembrane protein s G protein coupled receptor s Composed ... receptor and related nicotinicoid receptors journal J. Biol. Chem. volume 279 issue 19 pages ... at the interface between the subunits. receptor tyrosine kinase Functional receptors are homodimers ... s nuclear receptor s Composed of a C terminus C terminal DNA binding domain DBD and a N terminus ... left mathrm Ligand right cdot left mathrm Receptor right overset K d rightleftharpoons left text Ligand receptor complex right math the brackets stand for concentrations center One measure of how well ... more details
Imidazoline receptors are receptor biochemistry receptor s for clonidine and other imidazoline s. ref name pmid16529547 cite journal author Head GA, Mayorov DN title Imidazoline receptors, novel agents and therapeutic potential journal Cardiovasc Hematol Agents Med Chem volume 4 issue 1 pages 17 32 year 2006 month January pmid 16529547 url http www.bentham direct.org pages content.php?CHAMC 2006 00000004 00000001 003AE.SGM doi 10.2174 187152506775268758 ref Classes There are three classes of imidazoline receptors ref name pmid16529547 I sub 1 sub receptor mediates the sympatho inhibitory actions of imidazolines to lower blood pressure, NISCH or IRAS, imidazoline receptor antisera selected I sub 2 sub receptor an allosteric regulation allosteric binding site of monoamine oxidase and is involved in pain modulation and neuroprotection. I sub 3 sub receptor regulates insulin secretion from pancreatic beta cell s Activated I sub 1 sub imidazoline receptors trigger the hydrolysis of phosphatidylcholine into diacylglycerol DAG . Elevated DAG levels in turn trigger the synthesis of second messenger system second messenger s arachidonic acid and downstream eicosanoids . ref name pmid10415895 cite journal author Ernsberger P title The I1 imidazoline receptor and its cellular signaling pathways journal Ann. N. Y. Acad. Sci. volume 881 issue 1 pages 35 53 year 1999 month June pmid 10415895 .... The I sub 1 sub imidazoline receptor may belong to the neurocytokine receptor family, since ... I sub 2 sub receptor agonist BU224 selective I sub 2 sub receptor agonist, low efficacy LNP 911 ... Efaroxan non selective, binds to I sub 1 sub receptor and sub 2 sub adrenoceptor Idazoxan non selective, binds to I sub 2 sub receptor and sub 2 sub adrenoceptor BU99006 alkylating agent, inactivates I sub 2 sub receptors Imidazoline I sub 2 sub receptor antagonists reversibly block NMDA receptor ... by imidazoline I 2 receptor antagonists journal Eur. J. Pharmacol. volume 629 issue 1 3 pages ... more details
Unreferenced date December 2009 Insulin dependent diabetes mellitus IDDM is a medical term that describes diabetes mellitus that requires insulin therapy to avoid diabetic ketoacidosis ketoacidosis . IDDM is often considered a synonym for juvenile diabetes mellitus and type 1 diabetes mellitus , though the three terms are not entirely congruent Juvenile diabetes is considered an unsatisfactory and somewhat obsolete term because type 1 diabetes can develop in adults, and type 2 can occur in children. IDDM includes type 1 diabetes, but as type 2 diabetes progresses, in some people it may reach a degree of insulin deficiency that requires insulin treatment. See diabetes mellitus , type 1 diabetes mellitus , and type 2 diabetes mellitus . DEFAULTSORT Insulin Dependent Diabetes Mellitus Category Diabetes ... more details
Multiple issues orphan January 2012 context June 2011 unreferenced June 2011 Chronic Insulin treatment is to treat the cell with insulin every 4 or 6 hours for 24 hours. It is to induce the cell to a status similar to type II diabetes . Category Diabetes Health stub ... more details
of the sub 2 sub receptor include inhibition of insulin release in the pancreas . ref name purves ... or adrenoceptors are a class of metabotropic G protein coupled receptor s that are targets of the catecholamine .... receptors have the subtypes Alpha 1 adrenergic receptor sub 1 sub a G protein G sub q sub coupled receptor and Alpha 2 adrenergic receptor sub 2 sub a G sub i sub coupled receptor . Phenylephrine is a selective agonist of the receptor. receptors have the subtypes Beta 1 adrenergic receptor sub 1 sub , Beta 2 adrenergic receptor sub 2 sub and Beta 3 adrenergic receptor sub 3 sub . All three are linked to G sub s sub proteins although Beta 2 adrenergic receptor sub 2 sub also ... M, Spurgeon H, Lakatta EG title G i dependent localization of beta 2 adrenergic receptor signaling ... receptors. Adrenaline or noradrenaline are receptor ligands to either Alpha 1 adrenergic receptor sub 1 sub , Alpha 2 adrenergic receptor sub 2 sub or adrenergic receptors. Alpha 1 adrenergic receptor sub 1 sub couples to Gq alpha subunit G sub q sub , which results in increased intracellular calcium Ca sup 2 sup which results in smooth muscle contraction. Alpha 2 adrenergic receptor ... rate in cardiac muscle. class wikitable Receptor Agonist potency order Selected action BR of agonist ... Alpha 1 adrenergic receptor sub 1 sub br Alpha 1A adrenergic receptor A , Alpha 1B adrenergic receptor B , Alpha 1D adrenergic receptor D sup sup style white space nowrap Norepinephrine epinephrine ... antidepressant TCA s Amitriptyline Clomipramine Doxepin Trimipramine Alpha 2 adrenergic receptor sub 2 sub br Alpha 2A adrenergic receptor A , Alpha 2B adrenergic receptor B , Alpha 2C adrenergic receptor C Epinephrine norepinephrine isoprenaline Smooth muscle mixed effects and neurotransmitter ... Beta 1 adrenergic receptor sub 1 sub Isoprenaline epinephrine norepinephrine Heart muscle ... receptor sub 2 sub Isoprenaline epinephrine norepinephrine Smooth muscle relaxation Gs alpha subunit ... more details
Interventions infobox Name Insulin shock therapy Image Insulin shock therapy.jpg Caption Insulin shock ... OtherCodes Insulin shock therapy or insulin coma therapy ICT was a form of psychiatric treatment in which patients were repeatedly injected with large doses of insulin in order to produce daily coma ... Insulin coma therapy in schizophrenia url http jrsm.rsmjournals.com cgi reprint 93 3 147.pdf journal ... ref Insulin coma therapy and the convulsive therapies Electroconvulsive therapy electro and cardiazol ... current uses and practices. Williamsburg p1. ref Although insulin coma therapy had disappeared in the USA ... of insulin to treat drug addicts and psychopaths. ref name Sakel MJ Sakel 1956 The classical Sakel shock ... patients with larger doses of insulin in order to produce coma and sometimes convulsions. ref ... visited Vienna in 1935 and 1936, and by 1938 thirty one hospitals in England and Wales had insulin treatment units. ref name Jones In 1936 Sakel moved to New York and promoted the use of insulin ... hospitals in the USA were using insulin coma treatment. ref GL Jones 1948 Psychiatric shock therapy current uses and practices. Williamsburg p17. ref Technique Insulin coma therapy was a labour ... insulin coma therapy on the wards url http jhmas.oxfordjournals.org cgi content abstract jrl044v1 ... days a week for about two months. ref name Neu The daily insulin dose was gradually increased to 100 ... thought that maximum benefit had been achieved, the dose of insulin was rapidly reduced ... Allen After the insulin injection patients would experience various symptoms of decreased blood glucose ... metrazol convulsive therapy during the coma, or on the day of the week when they didn t have insulin ... Sargant When they were not in a coma, insulin coma patients were kept together in a group and given ... Eric Cunningham Dax , instructs nurses to take their insulin patients out walking and occupy them ... after the coma. ref name Jones In modified insulin therapy , used in the treatment of neurosis, patients ... more details
author Albiston AL, Mustafa T, McDowall SG, Mendelsohn FA, Lee J, Chai SY title AT4 receptor is insulin ...protein Name Angiotensin II receptor type 1 angiotensin II receptor, type 1 caption image width HGNCid ... II receptor type 2 angiotensin II receptor, type 2 caption image width HGNCid 338 Symbol AGTR2 IUPHAR ... receptor s with angiotensin angiotensin II as their Ligand biochemistry ligand s. ref name pmid10977869 ... H, Frank GD, Eguchi S title Angiotensin II signal transduction through the AT1 receptor novel insights ... pmid 17346243 doi 10.1042 CS20060342 ref Structure The angiotensin II receptor type 1 AT sub 1 sub and angiotensin II receptor type 2 AT sub 2 sub receptors share a sequence identity of 30 , but have ... wikitable Receptor Mechanism ref Unless else specified in box, then ref is http senselab.med.yale.edu ... 3 sub 3 sub AT sub 3 sub AT sub 4 sub AT sub 1 sub AT1 redirects here Main Angiotensin II receptor type 1 The AT sub 1 sub receptor is the best elucidated angiotensin receptor. Location within ... The angiotensin receptor is activated by the vasoconstriction vasoconstricting peptide angiotensin angiotensin II . The activated receptor in turn couples to Gq alpha subunit G sub q 11 sub and Gi alpha ... kinase C . Activated receptor also inhibits adenylate cyclase and activates various tyrosine kinase s. ref name pmid17346243 Effects Effects mediated by the AT sub 1 sub receptor include Vasoconstrictor ... 2 sub AT2 redirects here Main Angiotensin II receptor type 2 AT sub 2 sub receptors are more plentiful in the fetus and neonate. The AT sub 2 sub receptor remains enigmatic and controversial. Effects mediated by the AT sub 2 sub receptor are suggested to include inhibition of cell growth , fetal ... journal author D Amore A, Black MJ, Thomas WG title The angiotensin II type 2 receptor causes constitutive growth of cardiomyocytes and does not antagonize angiotensin II type 1 receptor mediated ... subtypes include the AT sub 3 sub and AT sub 4 sub receptors. The AT sub 4 sub receptor is activated ... more details
PBB geneid 2642 The glucagon receptor is a 62 kDa protein that is activated by glucagon and is a member ... DJ title Structure function of the glucagon receptor family of G protein coupled receptors the glucagon ... 2002 pmid 12529935 doi 10.1080 10606820213687 url accessdate 2007 08 24 ref Stimulation of the receptor ... monophosphate cAMP . In humans, the glucagon receptor is encoded by the GCGR gene . ref name pmid8144028 ... S, Grant FJ, Biggs SH, Rosenberg GB title The human glucagon receptor encoding gene structure ... receptor gene to human chromosome band 17q25 journal Genomics volume 20 issue 2 pages 327 ... G, Carcassi C, Contu L, Julier C title A missense mutation in the glucagon receptor gene is associated with non insulin dependent diabetes mellitus journal Nat. Genet. volume 9 issue 3 pages 299 304 ... receptor in humans causes resistance to glucagon and is associated with pancreatic alpha cell ... of the human glucagon receptor is associated with hyperglucagonemia, alpha cell hyperplasia, and islet ... receptor in a pheochromocytoma. journal J. Clin. Endocrinol. Metab. volume 40 issue 4 pages 720 ... Partial purification and characterization of the glucagon receptor. journal FEBS Lett. volume 155 ... DJ, Occi JL, Hey PJ, et al. title Cloning and expression of a human glucagon receptor. journal ... receptor gene Gly40Ser heterogeneity in the association with diabetes mellitus. journal Diabetologia ... cite journal author Chambers SM, Morris BJ title Glucagon receptor gene mutation in essential ... dependent expression of receptor genes for glucagon and glucagon like peptide 1 GLP 1 . journal Horm ... in men carrying the glucagon receptor gene Gly40Ser variant. journal J. Mol. Med. volume 79 issue ..., Kasamatsu T, Dib SA, et al. title Role of the Gly40Ser mutation in the glucagon receptor gene in Brazilian ... Osborne H, et al. title Three distinct epitopes on the extracellular face of the glucagon receptor ... A, Yakymovych M, et al. title Proteins associated with type II bone morphogenetic protein receptor ... more details
content abstract 78 1 227 pmid 9457174 ref Function The primary function of the sulfonylurea receptor ... channel s increasing intracellular calcium concentrations which triggers exocytosis of insulin . Tissue distribution The isoforms of the sulfonylurea receptor have the following tissue distribution ... to type 2 diabetes . ref name Reis cite journal author Reis AF, Velho G title Sulfonylurea receptor ... 2 External links MeshName sulfonylurea receptor ABC transporters gene 12 stub ... more details
Intracellular receptors are receptor biochemistry receptor s located inside the cell biology cell rather than on its cell membrane . Examples are the class of nuclear receptor s located in the cell nucleus and the IP3 receptor IP sub 3 sub receptor located on the endoplasmic reticulum . The ligand s that bind to them are usually intracellular second messenger s like inositol trisphosphate IP sub 3 sub and extracellular lipophilicity lipophilic hormone s like steroid hormone s. Some intracrine peptide hormone s also have intracellular receptors. Members This list is mirrored on receptor biochemistry and nuclear receptor please update all simultaneously Transcription factors Steroid hormone receptor Sex hormone receptor s sex hormone s Estrogen receptor and Androgen receptor one type Vitamin D receptor vitamin D , one type Glucocorticoid receptor glucocorticoid s, one type Mineralocorticoid receptor mineralocorticoids , one type Thyroid hormone receptor and Retinoic acid receptor vitamin A and related compounds Peroxisome proliferator activated receptor s PPARs, , and Retinoid X receptor Farnesoid X receptor Liver X receptor Pregnane X receptor Constitutive androstane receptor Various Sigma 1 receptor Sigma sub 1 sub neuroactive steroid neurosteroids IP3 receptor IP sub 3 sub receptor inositol triphosphate , IP sub 3 sub See also Receptor biochemistry Receptor Steroid hormone External links http www.nuclear receptor.com Nuclear Receptor journal homepage http nrr.georgetown.edu NRR nrrhome.htm Nuclear receptor resource at Georgetown University http www.nursa.org Nuclear receptor signalling atlas NURSA, open access journal Transcription factors Cell signaling Category Intracellular receptors Intracellular receptors it Recettore intracellulare zh ... more details
receptors include the insulinreceptor , the Insulin like growth factor 1 receptor , the MuSK receptor , the Vascular Endothelial Growth Factor or VEGF receptor, etc. The substrate proteins which ...PBB geneid 4914 High affinity nerve growth factor receptor also known as neurotrophic tyrosine kinase receptor type 1 or TRK1 transforming tyrosine kinase protein or Trk A is a protein that in humans is encoded ... doi 10.1038 319743a0 ref This gene encodes a member of the Trk receptor neurotrophic tyrosine kinase receptor NTKR family . This kinase is a membrane bound receptor that, upon neurotrophin binding, phosphorylates ... cite web title Entrez Gene NTRK1 neurotrophic tyrosine kinase, receptor, type 1 url http www.ncbi.nlm.nih.gov ... affinity catalytic receptor for the neurotrophin , Nerve Growth Factor , or NGF . As such, it mediates ... of apoptosis programmed cell death . The TrkA receptor is part of the large family of receptor ... to a the certain tyrosine s on target protein s, or substrate biochemistry substrates . A receptor ... 05 00223 X ref The Low Affinity Nerve Growth Factor Receptor There is one other NGF receptor besides TrkA, called the LNGFR for Low Affinity Nerve Growth Factor Receptor . As opposed to TrkA, the LNGFR ... of TrkA receptor was found in keratoconus affected corneas, along with an increased level of repressor ... ubiquitiniation can be regulated by the other, unrelated receptor for NGF, p75NTR 5 . Interactions TrkA ... nerve growth factor receptor journal J. Neurosci. Res. volume 59 issue 3 pages 356 64 pmid 10679771 ... growth factor receptor signaling in rat pheochromocytoma PC12 cells journal J. Biol. Chem. volume ... growth factor receptor tyrosine kinase, TrkA journal J. Biol. Chem. volume 275 issue 24 pages ... factor in complex with the ligand binding domain of the TrkA receptor journal Nature journal Nature ... 2000 month March title Direct interaction of nerve growth factor receptor, TrkA, with non receptor ... adapter FRS 2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model ... more details
PBB geneid 886 Infobox protein family Symbol CholecysA Rec N Name Cholecystokinin A receptor, N terminal ... of the cholecystokinin a receptor by nmr spectroscopy Pfam PF09193 Pfam clan InterPro IPR015276 SMART PROSITE MEROPS SCOP 1d6g TCDB OPM family OPM protein CAZy CDD The Cholecystokinin A receptor is a human ... coupled receptor that binds non sulfated members of the cholecystokinin CCK family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor ... Gene CCKAR cholecystokinin A receptor url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... of the cholecystokinin A receptor with its corresponding Hormone hormonal ligand biochemistry ligand ... 8 and N terminus of the cholecystokinin A receptor by NMR spectroscopy journal Biochemistry ... IQM 95333 JNJ 17156516 See also Cholecystokinin receptor Cholecystokinin antagonist References reflist ... receptor gene in association with gallstones and obesity. journal Gastroenterology volume 109 issue ... cholecystokinin type A receptor. journal Biochem. Biophys. Res. Commun. volume 194 issue 2 pages ... A receptor. journal Biochem. Biophys. Res. Commun. volume 193 issue 1 pages 204 11 year 1993 ... al. title Identification of two amino acids of the human cholecystokinin A receptor that interact with the N ... CM, et al. title Human cholecystokinin type A receptor gene cytogenetic localization, physical mapping, and identification of two missense variants in patients with obesity and non insulin dependent diabetes ... 195 of the cholecystokinin A receptor interacts with the sulfated tyrosine of cholecystokinin and is crucial for receptor transition to high affinity state. journal J. Biol. Chem. volume 273 issue 23 ... Y, Miyasaka K title Mechanism of cholecystokinin A receptor antagonist on human pancreatic exocrine secretion. Localization of CCK A receptor in the human duodenum. journal Digestion volume 60 ... more details
proteins. One of the known target genes of androgen receptor activation is insulin like growth ... width caption crystal structure of the human androgen receptor ligand binding domain bound with an androgen receptor nh2 terminal peptide, ar20 30, and r1881 Pfam PF02166 Pfam clan InterPro IPR001103 SMART PROSITE MEROPS SCOP TCDB OPM family OPM protein CAZy CDD File Human androgen receptor and androgen binding.svg thumb 294 px Normal function of the androgen receptor. Testosterone T enters the cell ..., the androgen receptor AR undergoes a conformational change and releases heat shock proteins hsps ... KB, el Awady MK, Wilson EM, French FS title Androgen receptor defects historical, clinical ... LK, Trifiro MA title Molecular pathology of the androgen receptor in male in fertility journal Reprod ... repeats in the human androgen receptor a molecular basis for disease journal J. Mol. Endocrinol ... receptor in prostate and ovarian malignancies journal Front. Biosci. volume 8 issue pages d780 800 year 2003 month May pmid 12700055 doi 10.2741 1063 url ref The androgen receptor AR , also known as NR3C4 nuclear receptor subfamily 3, group C, member 4 , is a type of nuclear receptor ref name pmid17132855 ... of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily glucocorticoid ... ref in the cytoplasm and then translocating into the nucleus. The androgen receptor is most closely related to the progesterone receptor , and progestin s in higher dosages can block the androgen receptor ... of the androgen receptor is as a DNA binding transcription factor that regulates gene expression ... edrv 8 1 1 ref however, the androgen receptor has other functions as well. ref name pmid12351684 cite ... receptor activation. ref name pmid16633980 cite journal author Davison SL, Bell R title ... receptor activating hormone in the Wolffian duct , whereas dihydrotestosterone is the main androgenic ... function from androgen receptor knockout models journal Hum Reprod Update volume 16 issue 5 ... more details
Encyclopedia
top
