Drugbox Verifiedfields changed verifiedrevid 458271012 IUPAC name Human interferon beta image Clinical data tradename Drugs.com drugs.com CONS interferon beta 1b MedlinePlus a601151 pregnancy category legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID NA CAS number Ref cascite correct ?? CAS number 145155 23 3 ATC prefix L03 ATC suffix AB08 ATC supplemental PubChem DrugBank Ref drugbankcite correct drugbank DrugBank DB00068 KEGG Ref keggcite changed kegg KEGG D00746 ChEMBL Ref ebicite changed EBI ChEMBL 1201563 Chemical data C 908 H 1408 N 246 O 253 S 6 molecular weight 20011.0 g mol Interferon beta 1b tradenames Betaferon , Betaseron North America , Extavia and ZIFERON is a medication drug in the interferon family used to treat the relapsing remitting ... of the affliction as well as reduce the frequency of attacks. It is believed that interferon beta ... properties. Studies have also determined that interferon beta improves the integrity of the blood brain ... to interferon beta s beneficial effects. These studies were carried out in vitro , so it does not necessarily mean it works the same in people. Patients taking Interferon beta 1b may develop neutralizing ... America , now part of Bayer HealthCare. Novartis has also introduced Extavia, a new brand of interferon beta 1b, in 2009. In 2010 ZIFERON a new brand for interferon beta 1b has also been brought in by Zistdaru Danesh Ltd. Closely related is interferon beta 1a , also indicated for MS, and with a very similar drug profile. See also Interferon beta 1a Multiple sclerosis References Reflist External links http www.betaseron.com betaseron.com Interferons Immunostimulants DEFAULTSORT Interferon Beta 1b Category Cytokines Category Immunostimulants cs Interferon beta 1b it Interferone beta 1b he 1b nl Interferon b ta 1b pl Interferon beta 1b ru sr Interferon beta 1b ... more details
Pegylated interferon PEG IFN is a class of medication that includes two different drugs as of 2008 ref name HepC2008 cite book last editor first Emilio Jirillo, title Hepatitis C virus disease immunobiology and clinical applications year 2008 publisher Springer location New York isbn 9780387713755 pages 237 url http books.google.ca books?id yjzazAgMWEUC&pg PA237 edition Online Ausg. ref Pegylated interferon alpha 2a Pegylated interferon alpha 2b In these formulation, polyethylene glycol is added to make interferon last longer in the body. ref http www.medscape.com viewarticle 407963 5 Hepatology Focus Update on Hepatitis C Treatment Pegylated Interferon ref They are used to treat both hepatitis B ref cite book first Hendryk Dancygier. With contributions by H. D. Allescher title Clinical Hepatology year 2010 publisher Springer Berlin Heidelberg location S.l. isbn 9783642045097 pages 765 url http books.google.ca books?id lrPX8C4p90QC&pg PA765 ref and hepatitis C . ref name HepC2008 References reflist Long comment to avoid being listed on short pages Category Antivirals Category Immunostimulants antiinfective drug stub antineoplastic drug stub sl Peginterferon ... more details
mergeto IFNB1 discuss Talk Interferon beta 1a Merge with IFNB1? date September 2011 drugbox Verifiedfields changed verifiedrevid 458271076 IUPAC name Human interferon beta image 1AU1 Human Interferon Beta01.png width 250 Clinical data pregnancy category FDA Class C routes of administration Sub cutaneous ... weight 20027.0 g mol Interferon beta 1a also interferon beta 1 alpha is a drug in the interferon ..., Lyseng Williamson KA title Spotlight on subcutaneous recombinant interferon beta 1a Rebif in relapsing ... doi 10.2165 00063030 200519050 00005 ref It is produced by mammalian cells, while Interferon beta ... for MS, though starting a course of interferons early may slow its progress. Interferon beta 1a ... . Overview It is believed that Interferon beta based drugs achieve their beneficial effect on MS progression via their inflammation anti inflammatory properties. Studies have also determined that Interferon ... date June 2010 This strengthening of the BBB may be a contributing factor to Interferon Beta s beneficial ... http www.nlm.nih.gov medlineplus druginfo meds a604005.html title Interferon beta 1a Subcutaneous Injection ref ref name Avonex cite web title Avonex Interferon beta la url http www.fda.gov downloads ... as well as relapsing forms of multiple sclerosis and is similar to the interferon beta protein produced ... name of recombinant Interferon beta 1 a, which is manufactured as biosimilar biogeneric in Iran ... Projekt Management VPM GmbH in Braunschweig, Germany. Related drugs Closely related is Interferon beta 1b , also may be indicated for Multiple Sclerosis, and with a very similar drug profile. Interferon ... is a new brand of interferon beta 1b to be marketed by Novartis beginning in 2009. See also Interferon beta 1b References Reflist Interferons DEFAULTSORT Interferon Beta 1a Category Cytokines Category Pfizer Category Immunostimulants cs Interferon beta 1a fa fr Interf ron b ta 1a it Interferone beta 1a he 1a nl Interferon b ta 1a ru 1a sr Interferon ... more details
PBB geneid 3458 Infobox protein family Symbol IFN gamma Name Interferon gamma image PDB 1eku EBI.jpg ... CAZy CDD Drugbox Verifiedfields changed verifiedrevid 458270952 IUPAC name Human interferon gamma 1b Clinical data tradename Drugs.com drugs.com monograph interferon gamma MedlinePlus a601152 pregnancy ... ChemSpiderID NA Chemical data C 761 H 1206 N 214 O 225 S 6 molecular weight 17145.6 g mol Interferon ... II class of interferon s. ref name pmid6180322 cite journal author Gray PW, Goeddel DV title Structure of the human immune interferon gene journal Nature volume 298 issue 5877 pages 859 63 year 1982 month August pmid 6180322 doi 10.1038 298859a0 url ref This interferon was originally called macrophage ... Naylor SL, Sakaguchi AY, Shows TB, Law ML, Goeddel DV, Gray PW title Human immune interferon gene ... accessdate ref Function IFN , or type II interferon, is a cytokine that is critical for innate immunity ..., Wilson CB title Regulation of interferon gamma during innate and adaptive immune responses journal ... Kumar S, et al. title Three dimensional structure of recombinant human interferon gamma journal Science ... molecules. ref name PDB 1FG9 see also Interferon gamma receptor Cellular responses to IFN are activated through its interaction with a heterodimeric receptor consisting of Interferon gamma receptor 1 IFNGR1 and Interferon gamma receptor 2 IFNGR2 . IFN binding to the receptor activates the JAK ... journal author Sadir R, Forest E, Lortat Jacob H. title The heparan sulfate binding sequence of interferon gamma increased the on rate of the interferon gamma interferon gamma receptor complex formation ... JP, et al. title NMR characterization of the interaction between the C terminal domain of interferon ..., Grimaud JA title Interferon gamma binds to heparan sulfate by a cluster of amino acids located in the C ... pmid1901275 Biological activity In contrast to Interferon type I interferon and Interferon type I interferon , which can be expressed by all cells, IFN is secreted by T helper cell s specifically ... more details
Found in cows and sheep, Interferon tau is the signal from the developing embryo to the mother that she is pregnant. It is secreted by the trophoblast cells into the uterine lumen in days 13 21 of pregnancy. It decreases endometrial oxytocin receptors, which then cannot stimulate PGF 2 alpha synthesis, preventing luteolysis . It promotes uterine implantation by increasing protein synthesis in glands. References Bagnell, C. 2005. Animal Reproduction . Rutgers University Department of Animal Sciences. Category Embryology Category Reproductive system ja ... more details
Drugbox Verifiedfields changed verifiedrevid 451190559 IUPAC name image width Clinical data tradename Drugs.com drugs.com international multiferon pregnancy US C pregnancy category legal UK legal US legal status routes of administration Subcutaneous, intramuscular Pharmacokinetic data bioavailability protein bound metabolism elimination half life Identifiers ChemSpiderID Ref chemspidercite changed chemspider ChemSpiderID NA CAS number Ref cascite correct ?? CAS number ATC prefix L03 ATC suffix AB01 ATC supplemental PubChem DrugBank Ref drugbankcite correct drugbank DrugBank Chemical data chemical formula molecular weight Interferon alfa International Nonproprietary Name INN , or HuIFN alpha Le , trade name Multiferon is a natural interferon alpha IFN which is obtained from the leukocyte fraction of human blood following induction with Sendai virus . Interferon alfa contains several naturally occurring IFN subtypes and is purified by affinity chromatography . Composition Interferon alfa contains a mixture of several proteins all with structural, serological and functional properties typical for natural interferon alpha IFN . The major subtypes identified are IFN 1 2, 8, 10, 14 and 21 IFN 2 and IFN 14 are glycosylated. The IFN content is expressed in international units per ml and the drug product is formulated in isotonic phosphate buffer solution pH 7.2 supplemented with human albumin, 1.5 mg ml. The albumin used is a medicinal product, which is approved in several countries, indicated for subcutane injection therapy. Pharmacology Summary of differences between IFN subtypes IFN 8 enhances the proliferation of human B cells as well as being able to activate natural killer NK cells. The subtypes 10 and 2 along with 8 are the best NK cell activators. Subtypes 21 and 2 enhance the expression of IFN gamma inducible protein 10 IP 10 in dendritic cells. Activated dendritic cells initiate immune responses and the expression of IP 10, a chemokine w ... more details
Drugbox Verifiedfields changed verifiedrevid 458271293 IUPAC name image width alt Clinical data tradename Drugs.com MedlinePlus licence EU EMA requires brand name licence US FDA may use generic name DailyMedID preference to licence US pregnancy AU A B1 B2 B3 C D X pregnancy US C pregnancy category legal AU S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled legal CA OTC, Rx only, Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD Benz POM, CD Anab POM or CD Inv POM legal US Rx only legal status dependency liability routes of administration Parenteral Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers CAS number Ref cascite correct ?? CAS number 118390 30 0 CAS supplemental ATCvet ATC prefix L03 ATC suffix AB09 ATC supplemental PubChem PubChemSubstance IUPHAR ligand DrugBank Ref drugbankcite changed drugbank DrugBank DB00069 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID NA UNII Ref fdacite correct FDA UNII KEGG Ref keggcite correct kegg KEGG ChEBI Ref ebicite correct EBI ChEBI ChEMBL Ref ebicite correct EBI ChEMBL Chemical data C 860 H 1353 N 227 O 255 S 9 molecular weight 19343 g mol smiles StdInChI Ref stdinchicite correct chemspider StdInChI StdInChI comment StdInChIKey Ref stdinchicite correct chemspider StdInChIKey synonyms density Interferon alfacon 1 is a recombinant synthetic Interferon type I type I interferon used for the treatment of hairy cell leukemia , melanoma malignant melanoma and AIDS related Kaposi s sarcoma . ref name DrugBank DrugBank DB00069 ref References references Category Immunostimulants Category Antivirals antineoplastic drug stub ... more details
Drugbox Verifiedfields changed verifiedrevid 461935673 name Interferon alpha n3 IUPAC name image width alt image2 width2 alt2 imagename else may use drug name drug name else may use imagename caption Clinical data tradename Drugs.com MedlinePlus licence EU EMA requires brand name licence US FDA may use generic name DailyMedID preference to licence US pregnancy AU A B1 B2 B3 C D X pregnancy US C pregnancy category legal AU S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled legal CA OTC, Rx only, Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD Benz POM, CD Anab POM or CD Inv POM legal US Rx only legal status dependency liability routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID NA CAS number Ref cascite correct ?? CAS number CAS supplemental ATCvet ATC prefix none if uncategorised ATC suffix ATC supplemental PubChem PubChemSubstance IUPHAR ligand DrugBank Ref drugbankcite changed drugbank DrugBank DB00018 UNII Ref fdacite correct FDA UNII KEGG Ref keggcite correct kegg KEGG ChEBI Ref ebicite correct EBI ChEBI ChEMBL Ref ebicite correct EBI ChEMBL Chemical data chemical formula C H Ag As Au B Bi Br Cl Co F Fe Gd I K Mn N Na O P Pt S Sb Se Sr Tc Zn charge molecular weight smiles StdInChI Ref stdinchicite correct chemspider StdInChI StdInChI comment StdInChIKey Ref stdinchicite correct chemspider StdInChIKey synonyms density melting point melting high melting notes boiling point boiling notes solubility specific rotation sec combustion Interferon alpha n3 Alferon N is a Pharmaceutical drug medication consisting of purified natural human Interferon type I IFN interferon alpha proteins used for the treatment of genital wart s. ref name DrugBank DrugBank DB00018 ref References references Category Immunostimulants Category Antivirals antineoplastic drug stub ... more details
Gerpferon Firn M with acyclovir , lidocaine ointment herpes See also Interferon References references ... S, Taira H, Hall A, et al. title Synthesis in E. coli of a polypeptide with human leukocyte interferon ... more details
protein Name interferon gamma receptor 2 interferon gamma transducer 1 caption image width HGNCid 5440 Symbol IFNGR2 AltSymbols IFNGT1 EntrezGene 3460 OMIM 147569 RefSeq NM 005534 UniProt P38484 PDB ECnumber Chromosome 21 Arm q Band 22.1 LocusSupplementaryData Interferon gamma receptor 2 also known as IFNGR2 is a protein which in humans is encoded by the IFNGR2 gene . ref name pmid3136170 cite journal author Luster AD, Weinshank RL, Feinman R, Ravetch JV title Molecular and biochemical characterization of a novel gamma interferon inducible protein journal J. Biol. Chem. volume 263 issue 24 pages 12036 43 year 1988 month August pmid 3136170 doi url http www.jbc.org cgi reprint 263 24 12036 issn ref Function This gene IFNGR2 encodes the non ligand binding beta chain of the interferon gamma receptor gamma interferon receptor . Human interferon gamma receptor is a heterodimer of interferon gamma receptor 1 IFNGR1 and IFNGR2. ref name entrez cite web title Entrez Gene IFNGR2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3460 accessdate ref Clinical significance Defects in IFNGR2 are a cause of Dominance genetics Autosomal recessive allele autosomal recessive mendelian susceptibility to mycobacterium mycobacterial disease MSMD , also known as familial disseminated atypical mycobacterial infection. ref name pmid19084105 cite journal author Al Muhsen S, Casanova JL title The genetic heterogeneity of mendelian susceptibility to mycobacterial diseases journal J. Allergy Clin. Immunol. volume 122 issue 6 pages 1043 51 quiz 1052 3 year 2008 month December pmid 19084105 doi 10.1016 j.jaci.2008.10.037 url issn ref References Reflist NLM content gene 21 stub Cytokine receptors sr Interferon gama receptor 2 ... more details
Infobox protein family Symbol IRF Name Interferon regulatory factor transcription factor image PDB 1irf EBI.jpg width caption interferon regulatory factor 2 dna binding domain, nmr, minimized average structure Pfam PF00605 Pfam clan InterPro IPR001346 SMART PROSITE MEROPS SCOP 1if1 TCDB OPM family OPM protein CAZy CDD Interferon regulatory factors are proteins which regulate Transcription genetics transcription of interferon s see regulation of gene expression . ref name pmid17399883 cite journal author Paun A, Pitha PM title The IRF family, revisited journal Biochimie volume 89 issue 6 7 pages 744 53 year 2007 pmid 17399883 doi 10.1016 j.biochi.2007.01.014 pmc 2139905 ref They are used in the JAK STAT signaling pathway . ref name IkezuGendelman2008 cite book author1 Tsuneya Ikezu author2 Howard E. Gendelman title Neuroimmune Pharmacology url http books.google.com books?id iGnLjvqvPboC&pg PA213 accessdate 28 November 2010 year 2008 publisher Springer isbn 9780387725727 pages 213 ref Interferon regulatory factors contain a conserved sequence conserved N terminal region of about 120 amino acids , which protein folding fold s into a secondary structure structure that binds specifically to the interferon consensus sequence ICS , which is located upstream and downstream DNA upstream of the interferon gene s. ref name pmid1460054 cite journal author Weisz A, Marx P, Sharf R, Appella E, Driggers PH, Ozato K, Levi BZ title Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon inducible genes journal J. Biol. Chem. volume ... of the interferon regulatory factor sequence vary depending on the precise function of the protein. ref ... BZ title Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon inducible genes journal J. Biol. Chem. volume 267 issue 35 pages 25589 ... IRF9 See also Interferon References Reflist External links MeshName Interferon regulatory factors ... more details
Interferon release assays IGRA are medical tests used in the diagnosis of some infectious diseases, especially tuberculosis . Interferon release assays rely on the fact that T lymphocytes will release interferon when exposed to specific antigens. These tests are mostly developed for the field of tuberculosis diagnosis , but in theory, may be used in the diagnosis of other diseases which rely on cell mediated immunity, e.g. cytomegalovirus and leishmaniasis . For example, in patients with cutaneous adverse drug reaction s, challenge of peripheral blood lymphocytes with the drug causing the reaction produced a positive test result for half of the drugs tested. ref cite web url http www.sciencedirect.com science? ob ArticleURL& udi B6WM8 4FC365G J& user 10& coverDate 02 2F28 2F2005& rdoc 1& fmt & orig search& sort d&view c& acct C000050221& version 1& urlVersion 0& userid 10&md5 e44c54a7f2706a47c104ffae7bbe376f title Clinical implications of in vitro drug induced interferon gamma release from peripheral blood lymphocytes in cutaneous adverse drug reactions ref There are currently two interferon release assays available for the diagnosis of tuberculosis QuantiFERON TB Gold licensed in US, Europe and Japan and T SPOT.TB , a form of ELISPOT licensed in Europe . The former test quantitates the amount of gamma interferon produced in response to the ESAT 6 and CFP 10 Wiktionary antigen antigens from Mycobacterium tuberculosis , which are distinguishable from those present in bacille Calmette Gu rin BCG and most other non tuberculous mycobacteria . The latter test determines the total number of individual effector T cells expressing gamma interferon . The indications for the test are still disputed. It has been evaluated for the diagnosis of latent tuberculosis in HIV patients who frequently have a negative Mantoux test . ref cite journal title Utility of interferon ELISPOT assay responses in highly tuberculosis exposed patients with advanced HIV infection in South Africa ... more details
protein Name IFNAR1 interferon alpha, beta and omega receptor 1 caption image width HGNCid 5432 Symbol IFNAR1 AltSymbols IFNAR EntrezGene 3454 OMIM 107450 RefSeq NM 000629 UniProt P17181 PDB ECnumber Chromosome 21 Arm q Band 22.1 LocusSupplementaryData protein Name IFNAR2 interferon alpha, beta and omega receptor 2 caption Protein nuclear magnetic resonance spectroscopy NMR structure of the interferon binding ectodomain of the human interferon receptor. ref name pmid12842042 PDB 1n6u cite journal author Chill JH, Quadt SR, Levy R, Schreiber G, Anglister J title The human type I interferon receptor NMR structure reveals the molecular basis of ligand binding journal Structure volume 11 issue 7 pages 791 802 year 2003 month July pmid 12842042 doi 10.1016 S0969 2126 03 00120 5 url ref image Biochem Mol..png width HGNCid 5433 Symbol IFNAR2 AltSymbols IFNABR EntrezGene 3455 OMIM 602376 RefSeq NM 207585 UniProt P48551 PDB ECnumber Chromosome 21 Arm q Band 22.1 LocusSupplementaryData The interferon receptor IFNAR is a receptor which binds interferon type I type I interferons including interferon and . It is a heteromeric receptor composed of one chain with two subunits referred to as IFNAR1 and IFNAR2 . ref name pmid17969444 cite journal author Uz G, Schreiber G, Piehler J, Pellegrini S title The receptor of the type I interferon family journal Curr. Top. Microbiol. Immunol. volume 316 issue pages 71 95 year 2007 pmid 17969444 doi 10.1007 978 3 540 71329 6 5 ref It is a cell surface receptor. Binding of cytokine follows a JAK STAT signaling pathway . Interferon stimulation results in an immunologic response that is especially associated with viruses. Structure The structure was obtained using NMR. Originally 35 conformers were calculated. This was narrowed to 22 with low ... that show probable common evolution. The domain, or evolutionary unit observed in nature, is the Interferon ... MeshName Receptor, Interferon alpha beta Cytokine receptors Category Cytokine receptors biochemistry ... more details
Infobox protein family Symbol IIGP Name Interferon inducible GTPase IIGP image PDB 1tpz EBI.jpg width caption crystal structure of iigp1 a paradigm for interferon inducible p47 resistance gtpases Pfam PF05049 Pfam clan CL0023 InterPro IPR007743 SMART PROSITE MEROPS SCOP TCDB OPM family OPM protein CAZy CDD In molecular biology, the interferon inducible GTPase IIGP protein family family of proteins is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localises to the endoplasmic reticulum and exerts a distinct role in Interferon IFN induced intracellular membrane trafficking or processing. ref name pmid11907101 cite journal author Zerrahn J, Schaible UE, Brinkmann V, Guhlich U, Kaufmann SH title The IFN inducible Golgi and endoplasmic reticulum associated 47 kDa GTPase IIGP is transiently expressed during listeriosis journal J. Immunol. volume 168 issue 7 pages 3428 36 year 2002 month April pmid 11907101 doi url ref Members of this family include interferon inducible GTPase 5 and IRGM immunity related GTPase family M protein . References reflist InterPro content IPR007743 Category Protein families ... more details
Unreferenced date June 2010 Image 1HIG Interferon Gamma01.png thumb 200px The 3D structure of human IFN A sole member makes up the type II IFNs that is called interferon gamma IFN gamma . Mature IFN is an anti parallel homodimer , which binds to the IFN receptor IFNGR complex to elicit a signal within its target cell. IFNGR is made up of two subunits each of molecules designated IFNGR1 and IFNGR2. Sources and functions interferon gamma IFN is involved in the regulation of the immune and inflammatory responses in humans, there is only one type of interferon gamma. It is produced in activated T cell s and natural killer cell s. IFN has some anti viral and anti tumor effects, but these are generally weak. However, this cytokine potentiates the effects of the type I IFNs. IFN released by T helper cell Th1 cell s recruits leukocyte s to a site of infection, resulting in increased inflammation. It also stimulates macrophage s to kill bacteria that have been engulfed. IFN released by Th1 cells is also important in regulating the Th2 response. As IFN is vitally implicated in the regulation of immune response, its production can lead to autoimmune disorder s. Homologs of interferon gamma are found in birds, frogs, and teleost fish. Thus it is likely that all bony fish tetrapods encode IFN . The gene structure of IFN is identical to that of its structurally related cytokines, except that the intron between the third and fourth exons does not exist. Notably, many teleost fish encode two distinct IFN species called IFN 1 and IFN 2 that appear to bind genetically and physically distinct IFN R1 chains. In all investigated tetrapods, there is a single IFN gene that binds a unique IFN R1 chain and in amniotes a unique IFN R2 chain. Frogs appear to encode two distinct IFN R2 genes whose intracellular domains differ significantly. External links MeshName Interferon Type II Interferons Category Cytokines Category Antivirals sr Interferon tip II zh II ... more details
protein Name interferon gamma receptor 1 caption Crystallographic structure of a 3 2 complex of the IFN receptor alpha chain IFNGR1 green, cyan, and green cyan and the interferon gamma IFN ligand biochemistry ligand red and orange . ref name PDB 1FG9 PDB 1FG9 cite journal author Thiel DJ, le Du MH, Walter RL, D Arcy A, Ch ne C, Fountoulakis M, Garotta G, Winkler FK, Ealick SE title Observation of an unexpected third receptor molecule in the crystal structure of human interferon gamma receptor complex journal Structure volume 8 issue 9 pages 927 36 year 2000 month September pmid 10986460 doi 10.1016 S0969 2126 00 00184 2 url ref image 1FG9 IFNG IFNG.png width HGNCid 5439 Symbol interferon gamma receptor 1 IFNGR1 AltSymbols IFNGR EntrezGene 3459 OMIM 107470 RefSeq NM 000416 UniProt P15260 PDB ECnumber Chromosome 6 Arm q Band 23 LocusSupplementaryData q24 protein Name interferon gamma receptor 2 interferon gamma transducer 1 caption image width HGNCid 5440 Symbol interferon gamma receptor 2 IFNGR2 AltSymbols IFNGT1 EntrezGene 3460 OMIM 147569 RefSeq NM 005534 UniProt P38484 PDB ECnumber Chromosome 21 Arm q Band 22.1 LocusSupplementaryData The interferon gamma receptor IFNGR is a receptor which binds Interferon gamma interferon , the sole member of interferon type II . Structure and function The human interferon gamma receptor complex consists the heterodimer of two chains interferon gamma receptor 1 IFNGR1 and interferon gamma receptor 2 IFNGR2 . ref name pmid9143700 cite journal author Bach EA, Aguet M, Schreiber RD title The IFN gamma receptor a paradigm for cytokine receptor signaling journal Annu. Rev. Immunol. volume 15 issue pages 563 91 year 1997 pmid 9143700 doi 10.1146 annurev.immunol.15.1.563 ref ref name pmid9462485 cite journal author Pestka S, Kotenko SV, Muthukumaran G, Izotova LS, Cook JR, Garotta G title The interferon gamma IFN gamma receptor a paradigm for the multichain cytokine receptor journal Cytokine Growth Factor Rev. volume 8 issue 3 pages ... more details
The recently classified type III interferon group consists of three IFN lambda molecules called IFN 1, IFN 2 and IFN 3 also called interleukin 29 IL29 , interleukin 28 IL28A and interleukin 28 IL28B respectively . ref cite journal author Vilcek J title Novel interferons journal Nat. Immunol. volume 4 issue 1 pages 8 9 year 2003 month January pmid 12496969 doi 10.1038 ni0103 8 ref These IFNs signal through a receptor complex consisting of IL10R2 also called CRF2 4 and IFNLR1 also called CRF2 12 . ref cite journal author Bartlett NW, Buttigieg K, Kotenko SV, Geoffrey L. Smith Smith GL title Murine interferon lambdas type III interferons exhibit potent antiviral activity in vivo in a poxvirus infection model journal J. Gen. Virol. volume 86 issue Pt 6 pages 1589 96 year 2005 month June pmid 15914836 doi 10.1099 vir.0.80904 0 url http vir.sgmjournals.org cgi pmidlookup?view long&pmid 15914836 ref Acceptance of this classification is less universal than that of type I and type II, and unlike the other two, it is not currently included in Medical Subject Headings . References reflist Interferons Category Cytokines Category Antivirals sr Interferon tip III ... more details
PBB geneid 3459 Interferon gamma receptor 1 IFNGR1 also known as CD119 C luster of D ifferentiation 119 , is a human gene . ref name entrez cite web title Entrez Gene IFNGR1 interferon gamma receptor 1 ... interferon gamma receptor. Purification, characterization, and preparation of antibodies journal ... Z, Merlin G title Molecular cloning and expression of the human interferon gamma receptor journal Cell ... 5 url ref Function IFNGR1 encodes the ligand binding chain alpha of the heterodimeric gamma interferon receptor, which is found on macrophages . Interferon gamma receptor 2 IFNGR2 encodes the non ligand ... interferon gamma receptor 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3459 accessdate ref Interactions Interferon gamma receptor 1 has been shown to Protein protein interaction interact with Interferon gamma . ref name pmid10986460 cite journal doi 10.1016 ... third receptor molecule in the crystal structure of human interferon gamma receptor complex ... O, Ihle J N year 1995 month Sep. title Interaction between the components of the interferon gamma ... laydate quote ref See also Cluster of differentiation Interferon gamma receptor References reflist ... van Loon AP, Ozmen L, Fountoulakis M, et al. title High affinity receptor for interferon gamma IFN ... C, Fellous M, Berger R title Human interferon gamma receptor 1 IFNGR1 gene maps to chromosome ... BF00210682 cite journal author Novick D, Orchansky P, Revel M, Rubinstein M title The human interferon ... Z, Merlin G title Molecular cloning and expression of the human interferon gamma receptor. journal ... Igarashi K, Garotta G, Ozmen L, et al. title Interferon gamma induces tyrosine phosphorylation of interferon gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its ... between interferon gamma and its soluble high affinity receptor. journal Nature volume 376 issue ... LS, Pollack BP, et al. title Interaction between the components of the interferon gamma receptor ... more details
PBB geneid 3439 Interferon alpha 1 13 is a protein that in humans is encoded by the IFNA1 gene . ref name pmid1385305 cite journal author Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO title Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia journal Genomics volume 14 issue 2 pages 437 43 year 1992 month Dec pmid 1385305 pmc doi 10.1016 S0888 7543 05 80238 1 ref ref name entrez cite web title Entrez Gene IFNA1 interferon, alpha 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3439 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon IFN gamma MIM 147570 is produced ... 120 of human immunodeficiency virus is a potent interferon inducer. journal AIDS Res. Hum. Retroviruses ... author Silverman RH, Sengupta DN title Translational regulation by HIV leader RNA, TAT, and interferon ... C3d receptor is an interferon alpha receptor. journal EMBO J. volume 10 issue 4 pages 919 26 year ... of interleukin 1 and tumor necrosis factor but depress production of interferon alpha, interferon ... interferon alpha genes are coordinately expressed and encode functional polypeptides. journal ... author Delfraissy JF, Wallon C, Galanaud P title Interferon alpha can synergize with interleukin 2 for human .... title Structural relationship of human interferon alpha genes and pseudogenes. journal J. Mol. Biol ... sequence of a cloned human leukocyte interferon cDNA. journal Gene volume 10 issue 1 pages ... interferon alpha. journal Nature volume 287 issue 5781 pages 401 8 year 1981 pmid 6159536 doi 10.1038 ... cloned human leukocyte interferon cDNAs. journal Nature volume 290 issue 5801 pages 20 6 year ... 11.16.5661 cite journal author Todokoro K, Kioussis D, Weissmann C title Two non allelic human interferon ... more details
PBB geneid 56269 Interferon inducible GTPase 5 also known as immunity related GTPase cinema 1 IRGC1 is an enzyme that in humans is encoded by the IRGC gene . ref name entrez cite web title Entrez Gene Immunity related GTPase family, cinema url http www.ncbi.nlm.nih.gov sites entrez?db gene&cmd retrieve&list uids 56269 accessdate 2011 12 16T10 50 33.749 08 00 ref References reflist Further reading refbegin 2 refend gene 19 stub Category EC 3.6.5 ... more details
Image 1AU1 Human Interferon Beta01.png thumb 200px The 3D structure of human IFN Human type I interferon s comprise a vast and growing group of IFN proteins. All type I IFNs bind to a specific cell surface receptor complex known as the IFN receptor Interferon alpha beta receptor IFNAR that consists of IFNAR1 and IFNAR2 chains. Homologous molecules to type I IFNs are found in many species, including all mammals, and some have been identified in birds, reptiles, amphibians and fish species. ref Schultz et al., The interferon system of non mammalian vertebrates. Developmental and Comparative Immunology, Volume 28, pages 499 508. ref Mammalian types The mammalian types are designated IFN alpha , IFN beta , IFN kappa , IFN delta , IFN epsilon , IFN tau , IFN omega , and IFN zeta, also known as limitin . ref Oritani and Tomiyama, Interferon limitin Novel type I Interferon that displays a narrow range of biological activity. International journal of hematology, 2004, Volume 80, pages 325 331 . ref ref Hardy et al., Characterization of the type I interferon locus and identification of novel genes. Genomics, 2004, Volume 84 pages 331 345. ref IFN The IFN proteins are produced by leukocytes . They are mainly involved in innate immune response against viral infection. They come in 13 subtypes that are called IFNA1 , IFNA2 , IFNA4 , IFNA5 , IFNA6 , IFNA7 , IFNA8 , IFNA10 , IFNA13 , IFNA14 , IFNA16 , IFNA17 , IFNA21 . These genes for these IFN molecules are found ... interferon alfa 2a Pegylated interferon alfa 2b IFN The IFN proteins are produced in large ..., New chromosomal mapping assignments for argininosuccinate synthetase pseudogene 1, interferon beta ... et al., Fever of recombinant human interferon alpha is mediated by opioid domain interaction with opioid .... References reflist External links MeshName Interferon Type I Interferons DEFAULTSORT Interferon Type I Category Cytokines Category Antivirals Category Immunostimulants ja I sr Interferon tip ... more details
Unreferenced stub auto yes date December 2009 Interferon Consensus Sequence binding protein ICSBP or Interferon Regulatory Factor 8 IRF 8 is a transcription factor that plays critical roles in the regulation of lineage commitment and in myeloid Cell biology cell maturation. The critical role for ICSBP is in the decision for a Common Myeloid Progenitor CMP to Cellular differentiation differentiate into a monocyte precursor cell. DEFAULTSORT Interferon Consensus Sequence Binding Protein Category Transcription factors Genetics stub Immunology stub ... more details
Infobox rfam Name Interferon gamma 5 UTR regulatory element image RF00259.jpg width caption Predicted secondary structure and sequence conservation of IFN gamma Symbol IFN gamma AltSymbols Rfam RF00259 miRBase miRBase family RNA type Cis regulatory element Cis reg Tax domain Eukaryota GO SO SO 0000204 CAS number EntrezGene HGNCid OMIM PDB RefSeq Chromosome Arm Band LocusSupplementaryData Interferon gamma 5 UTR regulatory elements are a family of regulatory RNA s. This family represents a pseudoknot containing stem loop structure found in the 5 UTR of interferon gamma mRNA. This structure is thought to be involved in translational regulation and the pseudoknot has been found to activate protein kinase R PKR which is known to be a translational inhibitor. Mutations in the pseudoknot structure have been found to reduce PKR activation and increase the translation of interferon gamma. ref cite journal last Ben Asouli first Y coauthors Banai Y, Pel Or Y, Shir A, Kaempfer R year 2002 title Human interferon gamma mRNA autoregulates its translation through a pseudoknot that activates the interferon inducible protein kinase PKR journal Cell volume 108 pages 221&ndash 232 pmid 11832212 doi 10.1016 S0092 8674 02 00616 5 issue 2 ref References reflist 1 External links Rfam id RF00259 name Interferon gamma 5 UTR regulatory element Category Cis regulatory RNA elements molecular cell biology stub ... more details
Infobox protein family Symbol IFNGR1 Name Interferon gamma receptor IFNGR1 image PDB 1fyh EBI.jpg width caption 1 1 complex between an interferon gamma single chain variant and its receptor Pfam PF07140 Pfam clan CL0159 InterPro IPR021126 SMART PROSITE MEROPS SCOP 1fg9 TCDB OPM family OPM protein CAZy CDD In molecular biology, the interferon gamma receptor IFNGR1 family is a Protein family family of proteins which includes several eukaryotic and viral interferon gamma receptor proteins . Members of this family include The Homo sapiens human interferon gamma receptor 1 , which is a member of the hematopoietic cytokine receptor superfamily. It is gene expression expressed in a membrane bound form in many cell biology cell types, and is over expressed in tumour cells. It comprises an extracellular portion of 229 amino acid residues, a single transmembrane region, and a cytoplasm cytoplasmic protein domain domain of 221 amino acid residues. As with other members of its superfamily, the cytokine binding sites are formed by a small set of closely spaced surface loop biochemistry loops that extend from a beta sheet core, much like antigen binding sites on antibodies . ref name pmid9367779 cite journal author Sogabe S, Stuart F, Henke C, Bridges A, Williams G, Birch A, Winkler FK, Robinson JA title Neutralizing epitopes on the extracellular interferon gamma receptor IFNgammaR alpha chain characterized by homolog scanning mutagenesis and X ray crystal structure of the A6 fab IFNgammaR1 108 complex journal J. Mol. Biol. volume 273 issue 4 pages 882 97 year 1997 month November pmid 9367779 doi 10.1006 jmbi.1997.1336 url ref The vaccinia virus interferon IFN gamma receptor biochemistry receptor IFN gammaR , which is a 43 kDa solubility soluble glycoprotein that is secreted from infected cells early during infection . IFN gammaR from vaccinia virus, cowpox virus and camelpox virus ... GL title The vaccinia virus soluble interferon gamma receptor is a homodimer journal J. Gen. Virol. volume ... more details
deficient individuals have been found as well ref . Dorman SE, Holland SM. Interferon gamma and interleukin ... Newport MJ, Holland SM, Levin M, et al. Inherited disorders of the interleukin 12 23 interferon gamma ... more details
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