Merge from IL 12 and IL 12 Receptor 1 Mutations date July 2011 protein Name Human Interleukin12 caption Crystal structure of human IL 12 image IL12 Crystal Structure.rsh.png width 200 HGNCid Symbol IL12 ... Name interleukin 12A caption image width HGNCid 5969 Symbol IL12A AltSymbols CLMF1, NKSF1, p35 EntrezGene 3592 OMIM 161560 RefSeq NM 000882 UniProt P29459 PDB ECnumber Chromosome 3 Arm p Band 12 LocusSupplementaryData q13.2 protein Name Interleukin12 subunit beta interleukin 12B caption Crystal structure ... 5 Arm q Band 31.1 LocusSupplementaryData 33.1 Interleukin12 IL 12 is an interleukin that is naturally ... 12A p35 and Interleukin12 subunit beta IL 12B p40 . The active heterodimer , and a homodimer of p40 are formed following protein synthesis. Functions IL 12 is involved in the differentiation of naive ... 12 through up regulation of the interleukin12 receptor and STAT4 . ref IL 12 and autoimmunity ... es Interleucina 12 id Interleukin12 it Interleuchina 12 ja 12 pl Interleukina 12 pt Interleucina 12 sr 12 sv Interleukin12 ... FG, Kapsenberg ML title IL 12 deficient dendritic cells, generated in the presence of prostaglandin ... cell s NC 37 in response to antigenic stimulation. Gene and structure IL 12 is composed ... killer cells natural killer NK cells, and reduces Interleukin 4 IL 4 mediated suppression of IFN . T cells that produce IL 12 have a coreceptor , CD30 , which is associated with IL 12 activity. IL 12 plays an important role in the activities of natural killer cells and T lymphocytes. IL 12 mediates ... seems to be a link between IL 2 and the signal transduction of IL 12 in NK cells. IL 2 stimulates the expression of two IL 12 receptors, IL 12R 1 and IL 12R 2, maintaining the expression of a critical protein involved in IL 12 signaling in NK cells . Enhanced functional response is demonstrated by interferon gamma IFN production and killing of target cells. IL 12 also has anti angiogenic activity ... more details
PBB geneid 3595 Interleukin12 receptor, beta 2 subunit is a subunit of the interleukin12 receptor . IL12RB2 is its human gene . ref name entrez cite web title Entrez Gene IL12RB2 interleukin12 receptor ... I transmembrane protein identified as a subunit of the interleukin12 receptor complex. The coexpression ... Interactions Interleukin12 receptor, beta 2 subunit has been shown to Protein protein interaction ... interaction between interleukin12 receptor beta 2 subunit and Jak2 tyrosine kinase Jak2 associates with cytoplasmic membrane proximal region of interleukin12 receptor beta 2 via amino terminus journal ... Airoldi I, Guglielmino R, Carra G, et al. title The interleukin12 and interleukin12 receptor system ... Presky DH, Yang H, Minetti LJ, et al. title A functional interleukin12 receptor complex is composed ... L, Barberis Maino L, Biffi M, et al. title Selective expression of an interleukin12 receptor component ..., et al. title Assignment of IL12RB1 and IL12RB2, interleukin12 receptor beta 1 and beta 2 chains, to human ... binding site in the interleukin12 receptor required for signaling journal J. Biol. Chem. volume ... K, Shibata F, Miura O, et al. title Physical interaction between interleukin12 receptor beta 2 subunit and Jak2 tyrosine kinase Jak2 associates with cytoplasmic membrane proximal region of interleukin ..., Westland R, et al. title Genomic organization of the human interleukin12 receptor beta2 chain gene ... of NFATc2 in the interleukin12 receptor beta 2 proximal promoter in human T helper cells journal ... individuals is associated with interleukin12 receptor beta 2 upregulation journal AIDS Res. Hum ... cloning of a human IL 12 receptor component. A new member of the cytokine receptor superfamily ... Zou J, Presky DH, Wu CY, Gubler U title Differential associations between the cytoplasmic regions of the interleukin12 receptor subunits beta1 and beta2 and JAK kinases. journal J. Biol. Chem. volume ... interactions between IL 12 and the high affinity IL 12 receptor complex journal J. Immunol. volume ... more details
PBB geneid 3594 Interleukin12 receptor, beta 1 is a subunit of the interleukin12 receptor . IL12RB1 , is its human gene . ref name entrez cite web title Entrez Gene IL12RB1 interleukin12 receptor, beta ... web title Entrez Gene IL12RB1 interleukin12 receptor, beta 1 url http www.ncbi.nlm.nih.gov sites entrez ..., van Dissel JT, Ottenhoff TH title Genetic variations in the interleukin12interleukin 23 receptor beta1 chain, and implications for IL 12 and IL 23 receptor structure and function. journal Immunogenetics volume 54 issue 12 pages 817 29 year 2003 pmid 12671732 doi 10.1007 s00251 002 0534 9 cite journal author Ling P, Gately MK, Gubler U, et al. title Human IL 12 p40 homodimer binds to the IL 12 ... interleukin12 IL 12 p40 homodimer a potent IL 12 antagonist. journal Eur. J. Immunol. volume 25 issue ... 8 cite journal author Presky DH, Yang H, Minetti LJ, et al. title A functional interleukin12 receptor ... cite journal author Gubler U, Presky DH title Molecular biology of interleukin12 receptors journal ... between the cytoplasmic regions of the interleukin12 receptor subunits beta1 and beta2 and JAK kinases ..., interleukin12 receptor beta 1 and beta 2 chains, to human chromosome 19 band p13.1 and chromosome .... title Severe mycobacterial and Salmonella infections in interleukin12 receptor deficient patients ... cite journal author Kawashima T, Kawasaki H, Kitamura T, et al. title Interleukin12 induces tyrosine phosphorylation of an 85 kDa protein associated with the interleukin12 receptor beta 1 ... Interleukin12 receptor beta1 deficiency in a patient with abdominal tuberculosis journal J. Infect ... to the hemopoietin receptor superfamily. This protein binds to interleukine 12 IL12 with a low ... R, Desai BB, et al. title Expression cloning of a human IL 12 receptor component. A new member ... S, Nariuchi H title IL 12 receptor IL 12R expression and accumulation of IL 12R beta 1 and IL 12R beta ... with the IL 12 receptor journal Arch. Biochem. Biophys. volume 368 issue 1 pages 147 55 year 1999 ... more details
to mammals. Interleukin12 Pfam box Symbol IL12 Name Interleukin12 alpha subunit Pfam PF03039 InterPro IPR004281 PROSITE PDB PDB 1f45 Interleukin12Interleukin12 IL 12 is a disulphide bonded heterodimer ... L title The interleukin12interleukin12 receptor system role in normal and pathologic immune ... protein production, osteoclast formation rowspan 2 Interleukin12 IL 12 rowspan 2 dendritic cell s, B cell s, T cell s, macrophage s rowspan 2 Interleukin12 receptor, beta 1 subunit CD212 IL12RB1 , Interleukin12 receptor, beta 2 subunit IR12RB2 activated ref name arizona T cell s, differentiation ... cytokines e.g. IL 1, IL 6 , IL 8, IL 10, IL 12Interleukin 14 IL 14 T cells and certain malignant ... by white blood cell s leukocyte s . The term interleukin derives from inter as a means ... of T, B, and hematopoietic cells. Interleukin receptors on astrocytes in the hippocampus ... dependent memory and long term potentiation via interleukin 1 signaling journal Brain, Behaviour, and Immunity ... Interleukin 1 Pfam box Symbol IL1 Name Interleukin 1 18 image 3LTQ.pdb.png width caption Crystallographic structure of human interleukin 1B. ref name pmid21182275 PDB 3LTQ cite journal author ... OPM protein Interleukin 1 alpha and interleukin 1 beta IL1A IL 1 alpha and IL1B IL 1 beta are cytokines ... human type II interleukin 1 receptor mRNA journal J. Biol. Chem. volume 271 issue 34 pages 20965 72 ... from cleavage of the extracellular portion of the membrane receptors. Both IL 1 receptors Interleukin 1 receptor, type I CD121a IL1R1 , Interleukin 1 receptor, type II CD121b IL1R2 appear to be well ..., IL 1 beta and Interleukin 1 receptor antagonist IL 1RA . The crystal structures of IL1A and IL1B ref ... of interleukin 1 beta at 2.0 A resolution journal Proc. Natl. Acad. Sci. U.S.A. volume 86 issue ... have been solved, showing them to share the same 12 stranded beta sheet structure as both the heparin ..., have been implicated in receptor binding. Molecular cloning of the Interleukin 1 Beta converting enzyme ... more details
Interleukin 35 IL 35 is an Interleukin12 IL 12 family cytokine that is produced by Regulatory T cell regulatory , but not effector, T cell T cells and plays a role in immune suppression. It is a dimeric protein composed of Interleukin12 IL 12 and Interleukin 27 IL 27 chains, which are encoded by two separate gene s called IL12A and EBI3 , respectively. Secreted by regulatory T cells T sub regs sub , IL 35 suppresses inflammation inflammatory responses of immune cells. Studies in mice show the absence of either IL 35 chain from regulatory T sub regs sub reduces the cells ability to suppress inflammation this has been observed during cell culture experiments and using an experimental model for inflammatory bowel disease . ref name pmid18033300 cite journal author Collison LW, Workman CJ, Kuo TT, et al. title The inhibitory cytokine IL 35 contributes to regulatory T cell function journal Nature volume 450 issue 7169 pages 566 9 year 2007 month November pmid 18033300 doi 10.1038 nature06306 url ref To produce its suppressive effects, IL 35 has selective activities on different T cell subsets it induces cell growth proliferation of T sub reg sub cell populations but reduces activity of T helper 17 cell T sub h sub 17 cell populations. ref name pmid17874423 cite journal author Niedbala W, Wei XQ, Cai B, et al. title IL 35 is a novel cytokine with therapeutic effects against collagen induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells journal Eur. J. Immunol. volume 37 issue 11 pages 3021 9 year 2007 month November pmid 17874423 doi 10.1002 eji.200737810 url ref References references interleukins Category Cytokines sr 35 ... more details
protein Name Interleukin 19 caption Crystal structure of human IL 19 image IL19 Crystal Structure.png width 250 px HGNCid 5990 Symbol IL19 AltSymbols , MDA1, ZMDA1, IL 10C EntrezGene 29949 OMIM 605687 RefSeq NM 153758 UniProt Q9UHD0 PDB 1N1F ECnumber Chromosome 1 Arm q Band 32.2 LocusSupplementaryData Interleukin 19 is a cytokine that belongs to the Interleukin 10 IL 10 family of cytokines along with several other interleukin s including interleukin 10 IL 10 , interleukin 20 IL 20 , interleukin 22 IL 22 , interleukin 24 IL 24 , interleukin 26 IL 26 , and several virus encoded cytokines. It signals through the same cell surface receptor IL 20R that is used by IL 20 and IL 24. The IL 19 gene is expressed in resting monocytes and B cells . It is up regulated in monocytes following stimulation with granulocyte macrophage colony stimulating factor GM CSF or lipopolysaccharide . ref Chang, C. et al., Crystal Structure of Interleukin 19 Defines a New Subfamily of Helical Cytokines. Journal of Biological Chemistry , 2003, Volume 278, pages 3308 3313. ref References references interleukins immunology stub it Interleuchina 19 sr 19 ... more details
PBB geneid 282617 Interleukin 28B interferon, lambda 3 is a protein that in humans is encoded by the IL28B gene . ref name entrez cite web title Entrez Gene Interleukin 28B interferon, lambda 3 url http www.ncbi.nlm.nih.gov sites entrez?db gene&cmd retrieve&list uids 282617 accessdate 2012 01 27T16 33 57.120 08 00 ref This gene encodes a cytokine distantly related to type I interferons and the IL 10 family. This gene, interleukin 28A IL28A , and interleukin 29 IL29 are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta IL10RB and interleukin 28 receptor, alpha IL28RA . provided by RefSeq, Jul 2008 . ref name entrez cite web title Entrez Gene Interleukin 28B interferon, lambda 3 url http www.ncbi.nlm.nih.gov sites entrez?db gene&cmd retrieve&list uids 282617 accessdate 2012 01 27T16 33 57.120 08 00 ref References reflist Further reading refbegin 2 Cite pmid 12469119 Cite pmid 12483210 Cite pmid 16413080 Cite pmid 16478884 Cite pmid 16539846 Cite pmid 16618774 Cite pmid 18987645 Cite pmid 19304895 Cite pmid 19457860 Cite pmid 19684573 refend gene 19 stub ... more details
Refimprove date February 2008 An interleukin receptor is a cytokine receptor for interleukin s. Types There are two main families of Interleukin receptors, type 1 cytokine receptors type 1 and type 2 cytokine receptors . Type 1 Type 1 interleukin receptors include ref name pmid15062641 cite journal author Subramaniam S, Stansberg C, Cunningham C title The interleukin 1 receptor family journal Dev. Comp. Immunol. volume 28 issue 5 pages 415 28 year 2004 month May pmid 15062641 doi 10.1016 j.dci.2003.09.016 url issn ref ref name pmid17027517 cite journal author Boraschi D, Tagliabue A title The interleukin 1 receptor family journal Vitam. Horm. volume 74 issue pages 229 54 year 2006 pmid 17027517 doi 10.1016 S0083 6729 06 74009 2 issn ref Type 1 interleukin receptors Type 2 Type 2 interleukin receptors include ref name pmid15123776 cite journal author Donnelly RP, Sheikh F, Kotenko SV, Dickensheets H title The expanded family of class II cytokines that share the IL 10 receptor 2 IL 10R2 chain journal J. Leukoc. Biol. volume 76 issue 2 pages 314 21 year 2004 month August pmid 15123776 doi 10.1189 jlb.0204117 url issn ref Type 2 interleukin receptors Other Interleukin 1 receptor and interleukin 18 receptor belong to the immunoglobulin superfamily . Interleukin 8 receptor , RANTES receptors CCR1 , CCR3 , CCR5 , CCR1 MIP 1 receptor , CXCR4 PF4 receptor , Colony stimulating factor 1 receptor M CSF receptor and NAP 2 receptor belong to the chemokine receptor family. References Reflist External links MeshName Receptors, Interleukin Cytokine receptors Category Immunology membrane protein stub it Recettore delle interleuchine ... more details
PBB geneid 3558 Interleukin 2 IL 2 is an interleukin , a type of cytokine signaling molecule in the immune ... interleukin, a soluble hormone like mediator of the immune system, to be discovered. A soluble factor ... cytokine shown to mediate its effects via a specific IL 2 receptor , and it was also the first interleukin ... designated the number 2 interleukin, it was the first interleukin molecule, receptor and gene to be discovered ... 0161 5890 81 90024 9 issue 12 ref and the IL 2 molecule was first purified to homogeneity by immunoaffinity ... to human interleukin 2 strategy and tactics year 1983 journal J. Immunol. volume 131 pages 1808 15 ... and expression of a cloned cDNA for human interleukin 2 year 1983 journal Nature volume 302 issue ... 2 was discovered to be a member of a family of cytokines, which also includes Interleukin 4 IL 4 , Interleukin 7 IL 7 , Interleukin 9 IL 9 , Interleukin 15 IL 15 and Interleukin 21 IL 21 . IL 2 signals ... during an immune response. ref cite journal author Cantrell DA, Smith KA title The interleukin ... 6427923 doi 10.1126 science.6427923 issue 4655 ref ref cite journal author Smith KA title Interleukin ... Stern J, Smith KA title Interleukin 2 induction of T cell G1 progression and c myb expression year ... ref ref cite journal author Beadling C, Johnson KW, Smith KA year 1993 title Isolation of interleukin ... KA year 2002 title DNA array analysis of interleukin 2 regulated immediate early genes journal Med ... interleukin 2 production year 1998 journal J. Exp. Med. volume 188 pages 287 296 pmid 9670041 ... self and non self. IL 2 has been found to be similar to interleukin 15 IL 15 in terms of function. ref cite journal author Waldmann TA title The biology of interleukin 2 and interleukin 15 implications ... cells . ref cite journal author Waldmann TA, Tagaya Y title The multifaceted regulation of interleukin ... annurev.immunol.17.1.19 ref The primary differences between IL 2 and interleukin 15 IL 15 are found ... name Interleukin 2 Fallahzadeh MK, Roozbeh J, Geramizadeh B , Namazi MR. Interleukin 2 serum levels ... more details
protein Name Interleukin 33 caption Solution structure of human interleukin 33. ref name pmid19836339 PDB 2KLL cite journal author Lingel A, Weiss TM, Niebuhr M, Pan B, Appleton BA, Wiesmann C, Bazan JF, Fairbrother WJ title Structure of IL 33 and its interaction with the ST2 and IL 1RAcP receptors insight into heterotrimeric IL 1 signaling complexes journal Structure volume 17 issue 10 pages 1398 410 year 2009 month October pmid 19836339 pmc 2766095 doi 10.1016 j.str.2009.08.009 url ref image 2KLL.pdb.png width HGNCid 16028 Symbol IL33 AltSymbols DV27, C9ORF26, IL1F11, NFHEV EntrezGene 90865 OMIM 608678 RefSeq NM 033439 UniProt O95760 PDB 2KLL ECnumber Chromosome 9 Arm p Band 24.1 LocusSupplementaryData Interleukin 33 IL 33 is a cytokine belonging to the IL 1 superfamily. IL 33 induces helper T cells , mast cell s, eosinophil s and basophil s to produce type 2 cytokines. This cytokine was previously named NF HEV cell nucleus nuclear factor NF in high endothelial venule s HEVs since it was originally identified in these specialized cells. ref name pmid12819012 cite journal author Baekkevold ES, Roussign M, Yamanaka T, Johansen FE, Jahnsen FL, Amalric F, Brandtzaeg P, Erard M, Haraldsen G, Girard JP title Molecular characterization of NF HEV, a nuclear factor preferentially expressed in human high endothelial venules journal Am. J. Pathol. volume 163 issue 1 pages 69 79 year 2003 month July pmid 12819012 pmc 1868188 doi 10.1016 S0002 9440 10 63631 0 url http ajp.amjpathol.org cgi pmidlookup?view long&pmid 12819012 ref IL 33 mediates its biological effects by interacting with the receptors ... interleukin IL 5 and interleukin 13 IL 13 from polarized helper T cells Th sub 2 sub cells. The induction ... X, Gorman DM, Bazan JF, Kastelein RA title IL 33, an interleukin 1 like cytokine that signals via ..., the 12 strands of the trefoil are arranged in three pseudorepeats of four strand ... interleukins immunology stub cs Interleukin 33 ru 33 sr 33 ... more details
3586 Interleukin 10 IL 10 or IL10 , also known as human cytokine synthesis inhibitory factor CSIF , is an anti ... cite web title Entrez Gene IL10 interleukin 10 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ... towards treatment with bacteria producing recombinant interleukin 10, showing the importance of interleukin 10 for counteracting excessive immunity in the human body. ref name pmid16716759 cite ... S, Peppelenbosch MP, Steidler L title A phase I trial with transgenic bacteria expressing interleukin ... year 2006 month June pmid 16716759 doi 10.1016 j.cgh.2006.03.028 url ref A study in mice has shown that interleukin ... MA, Nakae S, Kalesnikoff J, Tsai M, Galli SJ title Mast cell derived interleukin 10 limits skin ... IFN , Interleukin 2 IL 2 , Interleukin 3 IL 3 , Tumor necrosis factor alpha TNF and GM CSF made ... A title Crystal structure of interleukin 10 reveals the functional dimer with an unexpected topological ... June pmid 8590020 doi 10.1016 S0969 2126 01 00193 9 url ref Interleukin 10 is classified as a class 2 cytokine. The Class 2 alpha helical cytokines consist of interleukin 10 IL 10 , IL 19, IL 20, IL 22 ... author Pestka S, Krause CD, Sarkar D, Walter MR, Shi Y, Fisher PB title Interleukin 10 and related ... doi 10.1146 annurev.immunol.22.012703.104622 url ref Interactions Interleukin 10 has been shown to Protein protein interaction interact with Interleukin 10 receptor, alpha subunit . ref name pmid8248239 ... T A, Hsu D H, Bazan J F, Moore K W year 1993 month Dec. title A receptor for interleukin 10 is related ... 1995 month May. title Characterization of recombinant extracellular domain of human interleukin 10 ... Crystallogr. D Biol. Crystallogr. volume 57 issue Pt 12 pages 1908 11 publisher location Denmark issn .... title Purification of receptor complexes of interleukin 10 stoichiometry and the importance of deglycosylation ... laysummary laysource laydate quote ref The receptor complex for interleukin 10 also requires the IL10R2 ... S, Pezzotti M title Viral and murine interleukin 10 are correctly processed and retain their biological ... more details
PBB geneid 3567 Interleukin 5 or IL 5 is an interleukin produced by T helper cell T helper 2 cells and mast ... family namely Interleukin 3 IL 3 and GM CSF , this glycoprotein in its active form is a homodimer. ref ... revealed by the crystal structure at 2.4 A resolution of human interleukin 5. Nature 1993 363 ... in close proximity to the genes encoding Interleukin 3 IL 3 , Interleukin 4 IL 4 , and granulocyte macrophage ..., on human chromosome 5. Blood 1989 73 5 1142 1148. ref which are often co expressed in TH2 cells. Interleukin ... M, Tavernier J et al. Interleukin 5 synthesis by eosinophils association with granules and immunoglobulin ... S, Djukanovic R, Mueller R et al. Interleukin 4, 5, and 6 and tumor necrosis factor alpha in normal ... 2005 137 Suppl 1 55 9. Epub 2005 Jun 2. 55 59. ref Clinical significance Interleukin 5 has long been ... role in the pathology of this disease. ref Sanderson CJ. Interleukin 5, eosinophils, and disease. Blood 1992 79 12 3101 3109. ref The IL 5 Receptor The IL 5 receptor IL 5R belongs to the type I cytokine ... Growth Factor Rev 2001 12 1 19 25. ref Like many other cytokine receptors, alternative splicing ... der HJ, Fiers W et al. A human high affinity interleukin 5 receptor IL5R is composed of an IL5 specific ... associate with an interleukin 5 IL 5 receptor alpha and betac subunit, respectively, and are activated ... K. A critical cytoplasmic domain of the interleukin 5 IL 5 receptor alpha chain and its function in IL ... is also found in Interleukin 3 IL 3 and GM CSF receptors where it is associated the IL 3R and GM CSFR ... responsible for different signaling. EMBO J 1993 12 11 4181 4189. ref Effect of IL 5 on Eosinophils ... to survival. Interactions Interleukin 5 has been shown to Protein protein interaction interact with Interleukin ... Apr. title Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale ... and expression of the human interleukin 5 receptor journal J. Exp. Med. volume 175 issue 2 pages 341 ... protein box yes update summary no update citations no PDB Gallery geneid 3567 id Interleukin 5 ja ... more details
PBB geneid 3600 Interleukin 15 IL 15 is a cytokine with structural similarity to Interleukin 2 IL 2 . Like Interleukin 2 IL 2 , IL 15 binds to and signals through a complex composed of IL 2 IL 15 receptor beta chain IL 2 receptor CD122 and the common gamma chain gamma C, IL2RG CD132 . IL 15 is secreted by phagocytes mononuclear phagocytes and some other cells following infection by virus es . This cytokine induces cell proliferation of natural killer cell s cells of the innate immune system whose principal role is to kill virally infected cells. Gene Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. ref name entrez In humans, interleukin 15 is encoded by the IL15 gene . ref name pmid8178155 cite journal author Grabstein KH, Eisenman J, Shanebeck K, Rauch C, Srinivasan S, Fung V, Beers C, Richardson J, Schoenborn MA, Ahdieh M title Cloning of a T cell growth factor that interacts with the beta chain of the interleukin 2 receptor journal Science volume 264 issue 5161 pages 965 8 year 1994 month May pmid 8178155 doi 10.1126 science.8178155 ref Function Interleukin 15 IL 15 regulates T cell T and natural killer cell natural killer NK ... x L . ref name entrez cite web title Entrez Gene IL15 interleukin 15 url http www.ncbi.nlm.nih.gov ... 15 receptor are shared in common with the receptor for a structurally related cytokine called interleukin ... BD, Sacks JA, et al. title Interleukin 15 rescues tolerant CD8 T cells for use in adoptive immunotherapy of established tumors journal Nat. Med. volume 12 issue 3 pages 335 41 year 2006 month March pmid ... D title The cytokine network and interleukin 15 IL 15 in brain development journal Folia neuropathologica ... Role of interleukin 15 and interleukin 18 in inflammatory response journal Ann. Rheum. Dis. volume ... by interleukin 15 journal Cytokine Growth Factor Rev. volume 13 issue 6 pages 429 39 year ... no update citations yes id Interleukin 15 it Interleuchina 15 pl Interleukina 15 pt Interleucina ... more details
PBB geneid 3578 Interleukin 9 , also known as IL9 , is a cytokine cell signalling molecule belonging to the group of interleukin s. ref name entrez cite web title Entrez Gene IL9 interleukin 9 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3578 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The protein encoded by this gene is a cytokine produced by T cells and specifically by CD4 helper cells that acts as a regulator of a variety of hematopoietic ... the interleukin 9 receptor IL9R , which activates different signal transducer and activator STAT ... reading citations cite journal author Renauld JC, Houssiau F, Louahed J, et al. title Interleukin ... Modi WS, Pollock DD, Mock BA, et al. title Regional localization of the human glutaminase GLS and interleukin ... SC, et al. title Human interleukin 9 genomic sequence, chromosomal location, and sequences essential ..., Schibler KR, et al. title Effect of interleukin 9 on clonogenic maturation and cell cycle status of fetal ... pmid 1903074 doi cite journal author Merz H, Houssiau FA, Orscheschek K, et al. title Interleukin 9 ... growth factor P40 journal Cytokine volume 2 issue 1 pages 9 12 year 1991 pmid 2129501 doi 10.1016 ... author Yin T, Keller SR, Quelle FW, et al. title Interleukin 9 induces tyrosine phosphorylation ... 12 pages 5484 8 year 1993 pmid 8516290 doi 10.1073 pnas.90.12.5484 pmc 46745 cite journal author Demoulin JB, Uyttenhove C, Van Roost E, et al. title A single tyrosine of the interleukin 9 IL 9 receptor ... Nicolaides NC, Holroyd KJ, Ewart SL, et al. title Interleukin 9 A candidate gene for asthma journal ... by interleukin 9 journal J. Biol. Chem. volume 274 issue 36 pages 25855 61 year 1999 pmid 10464327 doi 10.1074 jbc.274.36.25855 cite journal author Lejeune D, Demoulin JB, Renauld JC title Interleukin ..., suppressor of cytokine signalling SOCS 2 and SOCS 3, but only SOCS 3 overexpression suppresses interleukin ... more details
protein Name Interleukin 27 caption image width HGNCid 19157 Symbol IL27 AltSymbols IL30, p28 EntrezGene 246778 OMIM 608273 RefSeq NM 145659 UniProt Q6P676 PDB ECnumber Chromosome 16 Arm p Band 11 LocusSupplementaryData protein Name EBI3 Epstein Barr virus induced 3 caption image width HGNCid 3129 Symbol EBI3 AltSymbols IL 27B EntrezGene 10148 OMIM 605816 RefSeq NM 005755 UniProt Q14213 PDB ECnumber Chromosome 19 Arm p Band 13 LocusSupplementaryData Interleukin 27 IL 27 is a heterodimer ic cytokine belonging to the Interleukin12 IL 12 family that is composed of two subunits Epstein Barr virus EBV induced gene 3 EBI3 also known as IL 27B and IL27 p28 known as interleukin 30 IL 30 . ref name pmid15793300 cite journal author title Analysis of interleukin 27 EBI3 p28 expression in Epstein Barr virus and human T cell leukemia virus type 1 associated lymphomas heterogeneous expression of EBI3 subunit by tumoral cells journal The American Journal of Pathology volume 166 issue 4 pages 1217 28 year 2005 month April pmid 15793300 pmc 1602381 doi 10.1016 S0002 9440 10 62340 1 url http ajp.amjpathol.org cgi content abstract 166 4 1217 last1 Larousserie first1 F last2 Bardel first2 E last3 Pflanz first3 S last4 Arnulf first4 B last5 Lome Maldonado first5 C last6 Hermine first6 O last7 Br geaud first7 L last8 Perennec first8 M last9 Brousse first9 N ref IL 27 is produced by antigen presenting cell s. ref name pmid14657353 cite journal author Lucas S, Ghilardi N, Li J, de Sauvage FJ title IL 27 regulates IL 12 responsiveness of naive CD4 T cells through Stat1 dependent and independent mechanisms journal Proceedings of the National Academy of Sciences of the United States of America volume 100 issue 25 pages 15047 52 year 2003 month December pmid 14657353 pmc 299900 doi 10.1073 pnas.2536517100 url ref IL 27 plays an important function in regulating the activity of B cell B and T cell T lymphocytes. ref name pmid16670296 cite journal author Larousserie F, Charlot P, Bardel E, Froger ... more details
saimiri gene journal J. Immunol. volume 150 issue 12 pages 5445 56 year 1993 pmid 8390535 doi url http www.jimmunol.org cgi content abstract 150 12 5445 ref Interleukin 17 is a cytokine that acts as a potent ...protein Name IL17A Interleukin 17A caption image width HGNCid 5981 Symbol IL17A AltSymbols IL17, CTLA8 EntrezGene 3605 OMIM 603149 RefSeq NP 002181 UniProt Q16552 PDB ECnumber Chromosome 6 Arm p Band 12 LocusSupplementaryData protein Name Interleukin 17B caption image width HGNCid 5982 Symbol IL17B AltSymbols ... 5 Arm q Band 32 34 LocusSupplementaryData protein Name Interleukin 17C caption image width HGNCid ... ECnumber Chromosome 16 Arm q Band 24 LocusSupplementaryData protein Name Interleukin 17D caption image ... Q8TAD2 PDB ECnumber Chromosome 13 Arm q Band 11 LocusSupplementaryData protein Name Interleukin 17E caption image width HGNCid 13765 Symbol IL17E AltSymbols Interleukin 25 IL 25 EntrezGene 64806 OMIM ... protein Name Interleukin 17F caption X ray crystallography Biological macromolecular crystallography ... OMIM 606496 RefSeq NP 443104 UniProt Q96PD4 PDB 1JPY ECnumber Chromosome 6 Arm p Band 12 LocusSupplementaryData Interleukin 17 IL 17 or IL 17A , originally identified as a transcript from a rodent T cell ... 4 oclc doi url accessdate ref Interleukin 17 as a family functions as a proinflammatory cytokine that responds ... s cellular matrix. Interleukin 17 acts synergistically with tumor necrosis factor and interleukin 1 . ref name pmid19710487 cite journal author Miossec P, Korn T, Kuchroo VK title Interleukin ... to a type I cell surface receptor called interleukin 17 receptor IL 17R of which there are at least ... also called interleukin 25 IL 25 , and IL 17F. All members of the IL 17 family have a similar protein ... and mouse homologs. ref name Kolls2004 cite journal author Kolls JK, Lind n A title Interleukin ... of many other cytokines such as Interleukin 6 IL 6 , G CSF , GM CSF , interleukin 1 IL 1 , TGF ... author Kawaguchi M, Kokubu F, Fujita J, Huang SK, Hizawa N title Role of interleukin 17F in asthma journal ... more details
protein Name Interleukin 27 caption image width HGNCid 19157 Symbol IL27 AltSymbols , IL30, p28 EntrezGene 246778 OMIM 608273 RefSeq NM 145659 UniProt Q6P676 PDB ECnumber Chromosome 16 Arm p Band 11 LocusSupplementaryData Interleukin 30 IL 30 is a protein with a molecular weight of 28 kilodalton s, which forms one chain of the heterodimer ic cytokine called interleukin 27 IL 27 , thus is sometimes called IL27 p28. The other chain of IL 27 is a molecule called Epstein Barr induced gene 3 EBI3 . IL 30 is a member of the long chain, 4 helix bundle family of cytokines, making it structurally similar to interleukin 6 IL 6 . ref S. Pflanz et al., IL 27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4 T cells. Immunity Volume, 2002, 16, pages 779 790. ref This gene for this molecule is now officially called IL 27 under HGNC guidelines. ref http www.gene.ucl.ac.uk nomenclature data get data.php?hgnc id 19157 ref References references interleukins immunology stub sr 30 ... more details
protein Name Interleukin 20 caption image width HGNCid 6002 Symbol IL20 AltSymbols , ZCYTO10, IL10D EntrezGene 50604 OMIM 605619 RefSeq NM 018724 UniProt Q9NYY1 PDB ECnumber Chromosome 1 Arm q32 Band LocusSupplementaryData Interleukin 20 IL 20 is a protein belonging to the Interleukin 10 IL 10 family of cytokine s. IL 20 is produced by activated keratinocyte s and monocyte s and transmits an intracellular signal through two distinct cell surface receptor complexes on keratinocytes and other epithelial cells . IL 20 regulates cell growth proliferation and differentiation cellular differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. In addition, IL 20 also causes cell expansion of multipotential hematopoietic progenitor cells. ref Rich, B.E. Kupper, T.S., Interleukin 20. Anti Inflammatory & Anti Allergy Agents in Medicinal Chemistry, 2006, Volume 5, Number 3, pages 243 250. ref References references interleukins immunology stub it Interleuchina 20 sr 20 ... more details
PBB geneid 50616 Interleukin 22 IL 22 is protein that in humans is encoded by the IL22 gene . ref name pmid10954742 cite journal author Dumoutier L, Van Roost E, Colau D, Renauld JC title Human interleukin 10 related T cell derived inducible factor molecular cloning and functional characterization as an hepatocyte ... IL 22 a member of a group of cytokine s called the Interleukin 10 IL 10 family or IL 10 superfamily including Interleukin 19 IL 19 , Interleukin 20 IL 20 , Interleukin 24 IL 24 , and Interleukin ... Y, Fisher PB title Interleukin 10 and related cytokines and receptors journal Annu. Rev. Immunol ... to a cell surface complex composed of Interleukin 22 receptor IL 22R1 and Interleukin 10 receptor IL ... Moore KW, de Waal Malefyt R, Coffman RL, O Garra A title Interleukin 10 and the interleukin 10 receptor ... WH, Foster J, Zhang Z, Stinson J, Wood WI, Goddard AD, Gurney AL title Interleukin IL 22, a novel ... jbc.M005304200 url ref It forms cell surface complexes with Interleukin 22 receptor IL 22R1 and Interleukin ... kinase s and transcription factors, especially STAT3 . It can induce Interleukin 20 IL 20 and Interleukin ... cytokine. IL 22 binds to a heterodimeric cell surface receptor composed of Interleukin 10 receptor IL 10R2 and Interleukin 22 receptor IL 22R1 subunits. ref name pmid18599299 Crystalization is possible ... W, Hofer A, Wolf P, et al. title Common polymorphisms in the interleukin 22 gene are not associated ... L, Bleicher L, et al. title Crystal structure of a soluble decoy receptor IL 22BP bound to interleukin ... doi 10.1002 art.24568 cite journal author Thompson CL, Plummer SJ, Tucker TC, et al. title Interleukin ... lymphoid tissue constitutively and selectively express the TH 17 cytokine interleukin 22 journal Blood volume 113 issue 17 pages 4008 10 year 2009 pmid 19244159 doi 10.1182 blood 2008 12 192443 pmc ... in psoriasis journal Eur. J. Immunol. volume 39 issue 12 pages 3570 81 year 2009 pmid 19830738 .... Clin. Invest. volume 119 issue 12 pages 3573 85 year 2009 pmid 19920355 doi 10.1172 JCI40202 pmc 2786807 ... more details
PBB geneid 3565 Infobox protein family Symbol IL4 Name Interleukin 4 image PDB 1itm EBI.jpg width caption analysis of the solution structure of human interleukin 4 determined by heteronuclear three dimensional ... PROSITE PDOC00655 MEROPS SCOP 2int TCDB OPM family OPM protein CAZy CDD Interleukin 4 , abbreviated ... It is closely related and has functions similar to Interleukin 13 . Its receptor is the Interleukin .... IL 4 decreases the production of Th1 cells, macrophages, IFN gamma, and dendritic cell IL 12. Overproduction ... mutation in the alpha subunit of the interleukin 4 receptor journal N. Engl. J. Med. volume 337 ... http www.eurekalert.org pub releases 1997 12 WUSo SISG 101297.php laysource eurekalert.org ref ... into M1 cells. An increase in repair macrophages M2 is coupled with secretion of Interleukin 10 ... Disulfide assignments in recombinant mouse and human interleukin 4 journal Biochemistry volume 30 issue ... TL, Trotta PP, Bugg CE title Crystal structure of recombinant human interleukin 4 journal J ... author Yokota T et al. title Isolation and characterization of a human interleukin cDNA clone, homologous ... cite journal author Apte SH, Baz A, Kelso A, Kienzle N title Interferon gamma and interleukin 4 reciprocally ... volume 5 issue 12 pages 1093 101 year 2006 pmid 16375755 doi 10.2174 138955705774933383 cite journal author Olver S, Apte S, Baz A, Kienzle N title The duplicitous effects of interleukin 4 on tumour ... refend External links MeshName Interleukin 4 http antibody antibodies.com product37896 search Interleukin 4 28IL 4 29, 13.5kD, Mouse, recombinant.html Interleukin 4 from Gentaur at Gentaur http arginine.chem.cornell.edu Structures IL4.html Recombinant Human Interleukin 4 from Cornell University http www.hon.ch Library Theme Allergy Glossary il4.html Interleukin 4 from Allergy Glossary at Health ... Category Protein domains ca Interleucina 4 es Interleucina 4 id Interleukin 4 it Interleuchina 4 nl IL 4 ja 4 pl Interleukina 4 pt Interleucina 4 ru 4 sr 4 sv Interleukin ... more details
PBB geneid 3576 Interleukin 8 IL 8 is a chemokine produced by macrophages and other cell types such as epithelial ... cells store interleukin 8 in Weibel Palade bodies journal J. Exp. Med. volume 188 issue 9 pages 1757 ... secretion of prestored interleukin 8 from Weibel Palade bodies of microvascular endothelial cells ... doi 10.1084 jem.188.9.1751 url ref In humans, the interleukin 8 protein is encoded by the IL8 gene ... protein coupled receptor G protein coupled serpentine receptors interleukin 8 receptor, alpha CXCR1 , and interleukin 8 receptor, beta CXCR2 . Expression and affinity to IL 8 is different in the two ... web title Entrez Gene IL8 interleukin 8 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... significance Interleukin 8 is often associated with inflammation. As an example, it has been cited ... . http www.ucsf.edu dpsl psoriasis.html . The fact that Interleukin 8 secretion is increased by oxidant ... dependent induction of interleukin 8 gene expression by tumor necrosis factor alpha evidence for an antioxidant ... high levels of interleukin 8, there is an increased risk of schizophrenia in her offspring. ref name ... M, Gorman JM, Susser ES title Elevated maternal interleukin 8 levels and risk of schizophrenia ... 15121655 doi 10.1176 appi.ajp.161.5.889 url ref High levels of Interleukin 8 have been shown to reduce ... interleukin 2, 6, and 8 levels before and during treatment with risperidone and haloperidol relationship ... also IL8RA Interleukin 8 receptor, alpha IL8RB Interleukin 8 receptor, beta References reflist Further ... title Interleukin 8, a chemotactic and inflammatory cytokine journal FEBS Lett. volume 307 issue 1 pages ... cytokines tumor necrosis factor alpha, interleukin 1 beta, interleukin 6 and interleukin 8 in the pathogenesis ... 5 series Advances in Immunology isbn 978 0 12 022481 4 cite journal author Chakravorty M title Ethnic ... PL, Yang PC title The role of interleukin 8 in cancer cells and microenvironment interaction journal ... reviews in medicinal chemistry volume 5 issue 12 pages 1093 101 year 2006 pmid 16375755 doi 10.2174 ... more details
PBB geneid 3603 Pro interleukin 16 is a protein that in humans is encoded by the IL16 gene . ref name pmid9144227 cite journal author Baier M, Bannert N, Werner A, Lang K, Kurth R title Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor journal Proc Natl Acad Sci ... ref ref name entrez cite web title Entrez Gene IL16 interleukin 16 lymphocyte chemoattractant ... distinct isoforms have been reported. ref name entrez Interleukin 16 IL 16 is a cytokine that released ... called lymphocyte chemoattractant factor LCF . ref name Cruikshank 1982 Since then, this interleukin ... WW, Kornfeld H, Center DM title Interleukin 16 journal J. Leukoc. Biol. volume 67 issue 6 pages 757 ... signaling Receptor biochemistry receptor for mature IL 16. Interactions Interleukin 16 has been ... Kurschner first C authorlink coauthors Yuzaki M year 1999 month Sep. title Neuronal interleukin 16 ... Reinhard year 2003 month Oct. title PDZ Domain mediated interaction of interleukin 16 precursor ... of interleukin 16 and its precursor on T lymphocyte activation and growth journal Growth Factors volume ... in medicinal chemistry volume 5 issue 12 pages 1093 101 year 2006 pmid 16375755 doi 10.2174 138955705774933383 ... N, Baier M, Werner A, Kurth R title Interleukin 16 or not? journal Nature volume 381 issue 6577 ... Increased expression of interleukin 16 in bronchial mucosa of subjects with atopic asthma journal ... DM, Wu DM, et al. title Processing and activation of pro interleukin 16 by caspase 3 journal J ... journal author M hlhahn P, Zweckstetter M, Georgescu J, et al. title Structure of interleukin 16 resembles ..., control the induction of the interleukin 16 promoter in T lymphocytes journal Proc. Natl. Acad. Sci ... cite journal author Kim HS title Assignment of human interleukin 16 IL16 to chromosome 15q26.3 by radiation ... Identification of a CD4 domain required for interleukin 16 binding and lymphocyte activation journal ... 1999 pmid 10477592 doi cite journal author Kurschner C, Yuzaki M title Neuronal interleukin 16 NIL ... more details
PBB geneid 3596 Interleukin 13 IL 13 is a protein that in humans is encoded by the IL13 gene . ref name pmid8096327 cite journal author Minty A, Chalon P, Derocq JM, Dumont X, Guillemot JC, Kaghad M, Labit C, Leplatois P, Liauzun P, Miloux B title Interleukin 13 is a new human lymphokine regulating inflammatory and immune responses journal Nature volume 362 issue 6417 pages 248 50 year 1993 month March pmid 8096327 doi 10.1038 362248a0 url ref ref name pmid8097324 cite journal author McKenzie AN, Culpepper JA, de Waal Malefyt R, Bri re F, Punnonen J, Aversa G, Sato A, Dang W, Cocks BG, Menon S title Interleukin 13, a T cell derived cytokine that regulates human monocyte and B cell function journal Proc. Natl. Acad. Sci. U.S.A. volume 90 issue 8 pages 3735 9 year 1993 month April pmid 8097324 pmc 46376 doi 10.1073 pnas.90.8.3735 url ref ref name pmid1408833 cite journal author Morgan JG, Dolganov GM, Robbins SE, Hinton LM, Lovett M title The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes journal Nucleic Acids Res. volume 20 issue 19 pages 5173 9 year 1992 month October pmid 1408833 pmc 334302 doi 10.1093 nar 20.19.5173 url ref ... on immune cells that are similar to those of the closely related cytokine Interleukin 4 IL 4 ... the alpha chain of the Interleukin 4 receptor IL 4 receptor IL 4R and at least one of two ... B, Neben TY, Karp CL, Donaldson DD title Interleukin 13 central mediator of allergic asthma ... respiratory diseases such as asthma . See also Interleukin 13 receptor , the IL 13 receptor References ... year 2001 pmid 11396683 doi cite journal author Skinnider BF, Kapp U, Mak TW title The role of interleukin ... C, et al. title Interleukin 13 in the skin and interferon gamma in the liver are key players in immune ... volume 5 issue 12 pages 1093 101 year 2006 pmid 16375755 doi 10.2174 138955705774933383 refend PDB ... 13 es Interleucina 13 id Interleukin 13 it Interleuchina 13 pl Interleukina 13 pt Interleucina 13 sr ... more details
of the heterodimeric cytokine interleukin 23 IL23 . IL23 is composed of this protein and the p40 subunit of interleukin12 IL12B . The receptor of IL23 is formed by the beta 1 subunit of IL12 IL12RB1 ... cytokine, interleukin12 IL 12 , and another called p19 the IL 23 alpha subunit . In other words, IL 23 is a dimer of Interleukin12 subunit beta p40 S S p19 . IL 23 is an important part of the inflammation ... 2006 pmid 17010592 doi 10.1016 j.coi.2006.09.008 ref Interactions Interleukin 23 has been shown to Protein protein interaction interact with Interleukin12 subunit beta . ref name pmid11114383 cite journal ... TH title Genetic variations in the interleukin12interleukin 23 receptor beta1 chain, and implications for IL 12 and IL 23 receptor structure and function journal Immunogenetics volume 54 issue 12 pages 817 29 year 2003 pmid 12671732 doi 10.1007 s00251 002 0534 9 cite journal author Kreymborg K, B hlmann U, Becher B title IL 23 changing the verdict on IL 12 function in inflammation and autoimmunity ...PBB geneid 51561 Interleukin 23 subunit alpha is a protein that in humans is encoded by the IL23A gene ... as distinct from IL 12 journal Immunity volume 13 issue 5 pages 715 25 year 2001 month Jan pmid ... interleukin 23, alpha subunit p19 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... on naive CD4 T cells, IL23 preferentially acts on memory CD4 T cells. ref name entrez Interleukin ..., IL 23 has been implicated in the development of cancerous tumors. In conjunction with interleukin ... from the classical Th1 and Th2 cells. Th17 cells produce interleukin 17 IL 17 , a proinflammatory ... such as interleukin 1 IL 1 , interleukin 6 IL 6 , TNF alpha , nitric oxide synthase NOS 2 , and chemokines ... similar as well as distinct from IL 12 journal Immunity volume 13 issue 5 pages 715 25 publisher ... doi 10.1517 14728222.9.6.1123 cite journal author Peluso I, Pallone F, Monteleone G title Interleukin12 and Th1 immune response in Crohn s disease pathogenetic relevance and therapeutic implication journal ... more details
PBB geneid 3562 Interleukin 3 , also known as IL 3 , is a protein that in humans is encoded by the IL3 gene . ref name entrez cite web title Entrez Gene IL3 interleukin 3 colony stimulating factor, multiple ... url ref Function Interleukin 3 IL 3 is an interleukin , a type of biological signal cytokine that can improve the body s natural response to disease as part of the immune system. It acts by binding to the interleukin ... is stimulated by Interleukin 7 IL 7 as well as stimulates proliferation of all cells in the myeloid ... Interleukin 3 originally was discovered by JN Ihle in mice. He found a T cell derived factor ... it interleukin 3. ref name pmid6971890 cite journal author Ihle JN, Pepersack L, Rebar L title Regulation ... E title Interleukin 3 journal Meth. Enzymol. volume 116 issue pages 540 552 year 1985 pmid 3003517 ... Interleukin 3 has been shown to Protein protein interaction interact with IL3RA . ref name ... G, Andrews R K, Berndt M C, Lopez A F year 1996 month Jun. title Human interleukin 3 IL 3 induces ... laysource laydate quote pmc 395466 ref See also Interleukin References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Wagemaker G title Interleukin 3 journal Biotherapy .... Lab. Med. volume 42 issue 12 pages 1347 1354 year 2005 pmid 15576295 doi 10.1515 CCLM.2004.253 cite ... interleukin 3 journal Ann. N. Y. Acad. Sci. volume 554 issue pages 167 176 year 1989 pmid 2544122 ... Kriz first8 Ronaid last9 Donahue first9 Robert E. cite journal author Le Beau MM title The interleukin ... factor cDNA clone identified by a conserved noncoding sequence in mouse interleukin 3 journal Gene ... 12 pages 5484 5488 year 1993 pmid 8516290 doi 10.1073 pnas.90.12.5484 pmc 46745 author separator , author2 ... FC title Human interleukin 3 IL 3 induces disulfide linked IL 3 receptor alpha and beta chain heterodimerization ... interleukin 3 journal J. Mol. Biol. volume 259 issue 3 pages 524 541 year 1996 pmid 8676386 doi ... The receptor binding site of human interleukin 3 defined by mutagenesis and molecular modeling journal ... more details
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