PBB geneid 163702 Interleukin28receptor, alphasubunit is a subunit for the interleukin28receptor . IL28RA is its human gene . The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta IL10RB . The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A IL28A , interleukin 28B IL28B , and interleukin 29 IL29 . The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. ref cite web title Entrez Gene IL28RA interleukin28receptor, alpha interferon, lambda receptor url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 163702 accessdate ref References reflist refbegin 2 PBB Further reading citations refend gene 1 stub Immune receptors Category Cytokine receptors 1 Category Type II cytokine receptors The PBB Controls template provides controls for Protein Box Bot, please see Template PBB Controls for details. PBB Controls update page yes require manual inspection no update protein box yes update summary yes update citations yes ... more details
Interleukin 5 receptoralphasubunit has been shown to Protein protein interaction interact with Protein ... of human interleukin 5 with its receptoralphasubunit. Large scale production, structural ... associate with an interleukin 5 IL 5 receptoralpha and betac subunit, respectively, and are activated ... Localization of the gene encoding the alphasubunit of human interleukin 5 receptor IL5RA to chromosome ... isoforms of the human interleukin 5 receptoralphasubunit. journal Proc. Natl. Acad. Sci. U.S.A. ... A, et al. title Interleukin 5 regulates the isoform expression of its own receptoralphasubunit. journal ...PBB geneid 3568 Interleukin 5 receptor, alpha IL5RA also known as CD125 C luster of D ifferentiation 125 is a subunit of the Interleukin 5 receptor . IL5RA also denotes its human gene . ref name entrez cite web title Entrez Gene IL5RA interleukin 5 receptor, alpha url http www.ncbi.nlm.nih.gov sites ... and chromosomal localization of the human interleukin 5 receptoralpha chain gene. journal ... receptoralphasubunit. Large scale production, structural, and functional studies of Drosophila ... IL 5 receptoralphasubunit gene. journal J. Biol. Chem. volume 270 issue 3 pages 1462 71 year 1995 ... A, et al. title JAK2 and JAK1 constitutively associate with an interleukin 5 IL 5 receptoralpha and betac ..., Zahn S, et al. title Biosensor analysis of dynamics of interleukin 5 receptorsubunit beta c interaction ... title summary text The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alphasubunit and a signal transducing beta subunit shared by the receptors for interleukin 3 IL3 , colony stimulating factor 2 CSF2 GM CSF , and interleukin 5 IL5 . The binding of this protein to IL5 depends on the beta subunit ... and expression of the human interleukin 5 receptor journal J. Exp. Med. volume 175 issue 2 pages 341 ... and expression of the human interleukin 5 receptor. journal J. Exp. Med. volume 175 issue 2 pages ... more details
PBB geneid 3590 Interleukin 11 receptor, alphasubunit is a subunit of the interleukin 11 receptor . IL11RA is its human gene . ref name entrez cite web title Entrez Gene IL11RA interleukin 11 receptor, alpha url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3590 accessdate .... ref name entrez cite web title Entrez Gene IL11RA interleukin 11 receptor, alpha url http www.ncbi.nlm.nih.gov ... journal author Ch rel M, Sorel M, Apiou F, et al. title The human interleukin 11 receptoralpha ... C, et al. title Molecular cloning and characterization of the human interleukin 11 receptoralpha ... and interleukin 11 receptoralpha chain genes generate a fusion mRNA in normal cells. Implication ... K, Carver J, et al. title Expression and function of interleukin 11 and its receptoralpha in the human ... al. title Functional expression of the interleukin 11 receptoralpha chain and evidence of antiapoptotic .... title Expression of interleukin 11 IL 11 and IL 11 receptoralpha in human gastric carcinoma and IL ... subunit in their high affinity receptors. This gene encodes the IL 11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary ..., Hudson KR, Heath JK title Identification of three distinct receptor binding sites of murine interleukin ... 11 receptoralpha as a candidate target in the progression of human prostate cancer journal ... Tsimanis A, Shtalrid M, Shvidel L, et al. title Expression of interleukin 11 receptor in CD38 positive ... 11 receptoralpha journal Ann. Oncol. volume 17 issue 1 pages 110 6 year 2006 pmid 16291580 ... of interleukin 11 and its receptor and their prognostic value in human breast cancer journal ... Controls to Stop updates. PBB Summary section title summary text Interleukin 11 is a stromal cell derived ... of an immunoglobulin like domain and a cytokine receptor like domain. Alternative splicing has ... M, Lebeau B, et al. title Molecular cloning of two isoforms of a receptor for the human hematopoietic ... more details
PBB geneid 3587 Interleukin 10 receptor, alphasubunit is a subunit for the interleukin 10 receptor . IL10RA ... Gene IL10RA interleukin 10 receptor, alpha url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3587 accessdate ref Interactions Interleukin 10 receptor, alphasubunit has been shown to Protein protein interaction interact with Interleukin 10 ref name pmid8248239 cite ... yes update citations yes DEFAULTSORT Interleukin 10 Receptor, AlphaSubunit Category Clusters of differentiation ... is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate 2 PI 3 kinase AKT pathway. Activation of this receptor ... December 1993 title A receptor for interleukin 10 is related to interferon receptors journal PNAS Proc ... extracellular domain of human interleukin 10 receptor journal J. Biol. Chem. volume 270 issue 21 pages ... A, Zdanov A date May 1999 title Purification of receptor complexes of interleukin 10 stoichiometry ... author Carson WE title The functional characterization of interleukin 10 receptor expression on human ... Ho AS title Functional regions of the mouse interleukin 10 receptor cytoplasmic domain journal ... first8 PJ last9 Chou first9 CC cite journal author Taniyama T title The human interleukin 10 receptor ... A receptor for interleukin 10 is related to interferon receptors journal Proc. Natl. Acad. Sci ... characterization of a second chain of the interleukin 10 receptor complex journal EMBO J ... 10 IL 10R1 complex reveals a shared receptor binding site journal Immunity volume 15 issue 1 pages ... journal author Donnelly RP, Dickensheets H, Finbloom DS title The interleukin 10 signal transduction ... cite journal author Tan JC title Characterization of recombinant extracellular domain of human interleukin ... more details
PBB geneid 9466 Interleukin 27 receptor, alpha is a subunit of the interleukin 27 receptor . IL27RA is its human gene . ref name entrez cite web title Entrez Gene IL27RA interleukin 27 receptor, alpha url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 9466 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text In mice, CD4 helper T cells differentiate into type 1 Th1 cells, which are critical for cell mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 Th2 cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. ref name entrez cite web title Entrez Gene IL27RA interleukin 27 receptor, alpha url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 9466 accessdate ref Interactions Interleukin 27 receptor, alphasubunit has been shown to Protein protein interaction interact with STAT1 . ref name pmid12734330 cite journal last Takeda first Atsunobu authorlink coauthors Hamano Shinjiro, Yamanaka Atsushi, Hanada Toshikatsu, Ishibashi Tatsuro, Mak Tak W, Yoshimura Akihiko, Yoshida Hiroki year 2003 month May. title Cutting edge ... class I cytokine receptor. journal Biochem. Biophys. Res. Commun. volume 246 issue 1 pages 82 90 year ... al. title Development of Th1 type immune responses requires the type I cytokine receptor TCCR. journal ... receptor for IL 27. journal J. Immunol. volume 172 issue 4 pages 2225 31 year 2004 pmid 14764690 doi ... I cytokine receptor. journal Proc. Natl. Acad. Sci. U.S.A. volume 104 issue 47 pages 18502 7 year ... more details
PBB geneid 53832 Interleukin 20 receptor, alphasubunit is a subunit for the interleukin 20 receptor . IL20RA is its human gene . ref name entrez cite web title Entrez Gene IL20RA interleukin 20 receptor, alpha url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 53832 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template ... is a receptor for interleukin 20 IL20 , a cytokine that may be involved in epidermal function. The receptor of IL20 is a heterodimeric receptor complex consisting of this protein and interleukin 20 receptor beta IL20B . This gene and IL20B are highly expressed in skin. The expression of both genes ... first8 AD last9 Gurney first9 AL cite journal author Blumberg H title Interleukin 20 discovery, receptor ... lymphokine interleukin 26 targets epithelial cells through the interleukin 20 receptor 1 and interleukin 10 receptor 2 chains journal J. Biol. Chem. volume 279 issue 32 pages 33343 33351 year ... 9 pages 791 806 year 1997 pmid 8889548 doi 10.1101 gr.6.9.791 cite journal author Xie MH title Interleukin IL 22, a novel human cytokine that signals through the interferon receptor related proteins ... author Dumoutier L title Cutting edge STAT activation by IL 19, IL 20 and mda 7 through IL 20 receptor ... SV last5 Renauld first5 JC cite journal author Wang M title Interleukin 24 MDA 7 MOB 5 signals through ... author Parrish Novak J title Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor ligand interactions mediate unique biological functions journal J. Biol ... author Pletnev S title Characterization of the recombinant extracellular domains of human interleukin 20 receptors and their complexes with interleukin 19 and interleukin 20 journal Biochemistry ... first9 Hiroyuki cite journal author Sheikh F title Cutting edge IL 26 signals through a novel receptor complex composed of IL 20 receptor 1 and IL 10 receptor 2 journal J. Immunol. volume 172 issue ... more details
PBB geneid 3601 Interleukin 15 receptor, alphasubunit is a subunit of the interleukin 15 receptor which is encoded by the gene ref name entrez EntrezGene 3601 ref IL15RA in humans. The IL 15 receptor is composed of three subunits IL 15R alpha, CD122, and CD132. Two of these subunits, CD122 and CD132, are shared with the receptor for IL 2, but IL 2 receptor has an additional subunit CD25 . The shared ... jbc.270.50.29862 title Functional Characterization of the Human Interleukin 15 Receptoralpha Chain ... of Exon 2 of Human Interleukin 15 Receptoralpha Chain mRNA Results in a Shortened Form with a Distinct ... IL 15 binding protein that is structurally related to the alpha chain of the IL 2 receptor ... BF00296817 title Mapping of the interleukin 5 receptor gene to human Chromosome 3 p25 p26 and to mouse ... K title Cutting edge The common gamma chain is an indispensable subunit of the IL 21 receptor complex ... title Reduced expression of Bcl 2 in CD8 T cells deficient in the IL 15 receptoralpha chain volume ... 10.1074 jbc.M312458200 title Identification of an Interleukin 15 Receptor binding Site on Human Interleukin ... IL 15 receptoralpha chain that behaves as a specific, high affinity IL 15 antagonist volume 173 issue ... separate biological effects. This may be due to effects of the respective alpha chains, which are unique to each receptor, the kinetics and affinity of cytokine cytokine receptor binding, or due to the availability ... of the beta and gamma chains of the IL 2 receptor by the novel cytokine IL 15 volume 13 issue 12 pages ... ref This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor ... can either result from alternative splicing of the mRNA encoding for the receptor or by shedding of the extra cellular domain of the receptor protein. References Reflist Further reading refbegin 2 ... first3 TA last4 Azimi first4 N title Human T cell lymphotropic virus type I Tax activates IL 15R alpha ... first5 H last6 Paus first6 R last7 Bulfone Paus first7 S title The IL 15R alpha chain signals through ... more details
PBB geneid 3577 Interleukin 8 receptor, alpha is a chemokine receptor . IL8RA is its human gene . IL8RA ... entrez cite web title Entrez Gene IL8RA interleukin 8 receptor, alpha url http www.ncbi.nlm.nih.gov ... Cells Jan 2010 ref See also Interleukin 8 receptor, beta Interleukin 8 receptorInterleukin 8 InterleukinInterleukinreceptor Interactions Interleukin 8 receptor, alpha has been shown to Protein ... receptor family. This protein is a receptor for interleukin 8 IL8 . It binds to IL8 with high affinity ... title Molecular evolution of the human interleukin 8 receptor gene cluster journal Nat. Genet. volume ... T last6 Wood first6 WI cite journal author Morris SW title Assignment of the genes encoding human interleukin 8 receptor types 1 and 2 and an interleukin 8 receptor pseudogene to chromosome 2q35 journal ... of a human interleukin 8 receptor journal Science volume 253 issue 5025 pages 1278 80 year 1991 ... first6 M.Patricia cite journal author Mollereau C title The high affinity interleukin 8 receptor gene ..., but not the type A, human interleukin 8 receptor journal J. Biol. Chem. volume 271 issue 34 pages ... Committee on Receptor Nomenclature and Drug Classification recommended name. The PBB Summary template ... spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, and IL8RBP ... of interleukin 8 CXCL8 IL 8 responses by repertaxin, a new inhibitor of the chemokine receptors ... Identification of G protein binding sites of the human interleukin 8 receptors by functional mapping .... title Physical association of Gi2alpha with interleukin 8 receptors journal J. Biol. Chem. volume .... cite journal author Lee J title Characterization of two high affinity human interleukin 8 receptors ... CA, Kim KJ title Monoclonal antibodies detect different distribution patterns of IL 8 receptor A and IL 8 receptor B on human peripheral blood leukocytes journal J. Immunol. volume 153 issue 12 pages ... of IL 8 receptor A B by IL 8 possible functions of each receptor journal J. Immunol. volume ... more details
PBB geneid 3588 Interleukin 10 receptor, beta subunit is a subunit for the interleukin 10 receptor . IL10RB is its human gene . ref name entrez cite web title Entrez Gene IL10RB interleukin 10 receptor ... J, et al. title The orphan receptor CRF2 4 is an essential subunit of the interleukin 10 receptor. journal ... receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex ... transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. ref name entrez cite web title Entrez Gene IL10RB interleukin 10 receptor, beta url http www.ncbi.nlm.nih.gov sites ... of the interferon interleukin 10 receptor gene cluster. journal Genome Res. volume 9 issue 3 ... through the interleukin 20 receptor 1 and interleukin 10 receptor 2 chains. journal J. Biol. Chem. volume ... Lutfalla G, Gardiner K, Uz G title A new member of the cytokine receptor gene family maps on chromosome ... CD, Izotova LS, et al. title Identification and functional characterization of a second chain of the interleukin 10 receptor complex. journal EMBO J. volume 16 issue 19 pages 5894 903 year 1997 pmid ..., Aggarwal S, Ho WH, et al. title Interleukin IL 22, a novel human cytokine that signals through the interferon receptor related proteins CRF2 4 and IL 22R. journal J. Biol. Chem. volume 275 issue 40 ... Roost E, Colau D, Renauld JC title Human interleukin 10 related T cell derived inducible factor molecular ... receptor. journal Proc. Natl. Acad. Sci. U.S.A. volume 98 issue 13 pages 7570 5 year 2001 ... title Crystal structure of the IL 10 IL 10R1 complex reveals a shared receptor binding site. journal ... journal author Sheppard P, Kindsvogel W, Xu W, et al. title IL 28, IL 29 and their class II cytokine receptor IL 28R. journal Nat. Immunol. volume 4 issue 1 pages 63 8 year 2003 pmid 12469119 doi ... antiviral protection through a distinct class II cytokine receptor complex. journal Nat. Immunol ... more details
PBB geneid 3595 Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor . IL12RB2 is its human gene . ref name entrez cite web title Entrez Gene IL12RB2 interleukin 12 receptor ... I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression ... Interactions Interleukin 12 receptor, beta 2 subunit has been shown to Protein protein interaction ... interaction between interleukin 12 receptor beta 2 subunit and Jak2 tyrosine kinase Jak2 associates with cytoplasmic membrane proximal region of interleukin 12 receptor beta 2 via amino terminus journal ... Airoldi I, Guglielmino R, Carra G, et al. title The interleukin 12 and interleukin 12 receptor system ... Presky DH, Yang H, Minetti LJ, et al. title A functional interleukin 12 receptor complex is composed of two beta type cytokine receptor subunits. journal Proc. Natl. Acad. Sci. U.S.A. volume 93 issue ... L, Barberis Maino L, Biffi M, et al. title Selective expression of an interleukin 12 receptor component ..., et al. title Assignment of IL12RB1 and IL12RB2, interleukin 12 receptor beta 1 and beta 2 chains, to human ... binding site in the interleukin 12 receptor required for signaling journal J. Biol. Chem. volume ... K, Shibata F, Miura O, et al. title Physical interaction between interleukin 12 receptor beta 2 subunit and Jak2 tyrosine kinase Jak2 associates with cytoplasmic membrane proximal region of interleukin ..., Westland R, et al. title Genomic organization of the human interleukin 12 receptor beta2 chain gene ... of NFATc2 in the interleukin 12 receptor beta 2 proximal promoter in human T helper cells journal ... individuals is associated with interleukin 12 receptor beta 2 upregulation journal AIDS Res. Hum ... cloning of a human IL 12 receptor component. A new member of the cytokine receptor superfamily ... Zou J, Presky DH, Wu CY, Gubler U title Differential associations between the cytoplasmic regions of the interleukin 12 receptor subunits beta1 and beta2 and JAK kinases. journal J. Biol. Chem. volume ... more details
PBB geneid 3594 Interleukin 12 receptor, beta 1 is a subunit of the interleukin 12 receptor . IL12RB1 , is its human gene . ref name entrez cite web title Entrez Gene IL12RB1 interleukin 12 receptor, beta ... web title Entrez Gene IL12RB1 interleukin 12 receptor, beta 1 url http www.ncbi.nlm.nih.gov sites entrez ..., van Dissel JT, Ottenhoff TH title Genetic variations in the interleukin 12 interleukin 23 receptor beta1 chain, and implications for IL 12 and IL 23 receptor structure and function. journal Immunogenetics ... 8 cite journal author Presky DH, Yang H, Minetti LJ, et al. title A functional interleukin 12 receptor complex is composed of two beta type cytokine receptor subunits journal Proc. Natl. Acad. Sci. U.S.A. ... between the cytoplasmic regions of the interleukin 12 receptor subunits beta1 and beta2 and JAK kinases ..., interleukin 12 receptor beta 1 and beta 2 chains, to human chromosome 19 band p13.1 and chromosome .... title Severe mycobacterial and Salmonella infections in interleukin 12 receptor deficient patients ... tyrosine phosphorylation of an 85 kDa protein associated with the interleukin 12 receptor beta 1 ... Interleukin 12 receptor beta1 deficiency in a patient with abdominal tuberculosis journal J. Infect ... IL 23 is composed of IL 12Rbeta1 and a novel cytokine receptorsubunit, IL 23R journal J. Immunol ... to the hemopoietin receptor superfamily. This protein binds to interleukine 12 IL12 with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide linked ... receptor but does not mediate biologic activity. journal J. Immunol. volume 154 issue 1 pages 116 27 ... interleukin 12 IL 12 p40 homodimer a potent IL 12 antagonist. journal Eur. J. Immunol. volume 25 issue ... R, Desai BB, et al. title Expression cloning of a human IL 12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130. journal J. Immunol. volume 153 ... cite journal author Gubler U, Presky DH title Molecular biology of interleukin 12 receptors journal ... more details
PBB geneid 53833 Interleukin 20 receptor beta chain is a protein that in humans is encoded by the IL20RB gene . ref name pmid11163236 cite journal author Blumberg H, Conklin D, Xu WF, Grossmann A, Brender T, Carollo S, Eagan M, Foster D, Haldeman BA, Hammond A, Haugen H, Jelinek L, Kelly JD, Madden K, Maurer MF, Parrish Novak J, Prunkard D, Sexson S, Sprecher C, Waggie K, West J, Whitmore TE, Yao L, Kuechle MK, Dale BA, Chandrasekher YA title Interleukin 20 discovery, receptor identification, and role in epidermal function journal Cell volume 104 issue 1 pages 9 19 year 2001 month Feb pmid 11163236 pmc doi 10.1016 S0092 8674 01 00187 8 ref ref name pmid16703417 cite journal author Wei CC, Hsu YH, Li HH, Wang YC, Hsieh MY, Chen WY, Hsing CH, Chang MS title IL 20 biological functions and clinical implications journal J Biomed Sci volume 13 issue 5 pages 601 12 year 2006 month Sep pmid 16703417 pmc doi 10.1007 s11373 006 9087 5 ref ref name entrez cite web title Entrez Gene IL20RB interleukin 20 receptor beta url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 53833 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Dumoutier L, Leemans C, Lejeune D, et al. title Cutting edge STAT activation by IL 19, IL 20 and mda 7 through IL 20 receptor complexes of two types. journal J. Immunol. volume 167 issue 7 pages 3545 9 year 2001 pmid 11564763 doi cite journal author Parrish Novak J, Xu W, Brender T, et al. title Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor ligand interactions mediate unique biological functions. journal J. Biol. Chem. volume 277 issue 49 pages 47517 23 year 2003 pmid ... of human interleukin 20 receptors and their complexes with interleukin 19 and interleukin 20. journal ... more details
PBB geneid 3597 Interleukin 13 receptor, alpha 1 , also known as IL13RA1 and CD213A1 cluster of differentiation 213A1 , is a human gene . ref name entrez cite web title Entrez Gene IL13RA1 interleukin 13 receptor, alpha 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptoralpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13 binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has ... Gene IL13RA1 interleukin 13 receptor, alpha 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3597 accessdate ref See also Interleukin 13 receptor References reflist ... cloning and characterization of the human interleukin 13 receptoralpha chain. journal J. Biol. Chem ..., Schrader JW title Characterization of the cytoplasmic domain of interleukin 13 receptoralpha. journal ... with the IL4R alpha of a functional IL 4 IL 13 receptor complex. journal FEBS Lett. volume ... of a soluble interleukin IL 13 binding protein. Evidence that it is distinct from the cloned Il 13 receptor and Il 4 receptoralpha chains. journal J. Biol. Chem. volume 272 issue 14 pages 9474 80 ... interleukin 13 receptor alpha1 gene. journal Immunogenetics volume 51 issue 11 pages 974 81 year ... nucleotide and repeat polymorphisms in two candidate genes, interleukin 4 receptor IL4RA and signal ..., Suto H, Ushio H, et al. title Up regulation of interleukin 13 receptor alpha1 on human keratinocytes ... LT, Kennedy MB, Seeburg PH title Domain interaction between NMDA receptor subunits and the postsynaptic ... M, et al. title Characterization of IL 4 and IL 13 signals dependent on the human IL 13 receptoralpha chain 1 redundancy of requirement of tyrosine residue for STAT3 activation. journal Int. Immunol ... biological activities of human interleukin 13. journal J. Biol. Chem. volume 276 issue 18 pages ... more details
Refimprove date February 2008 An interleukinreceptor is a cytokine receptor for interleukin s. Types There are two main families of Interleukin receptors, type 1 cytokine receptors type 1 and type 2 cytokine receptors . Type 1 Type 1 interleukin receptors include ref name pmid15062641 cite journal author Subramaniam S, Stansberg C, Cunningham C title The interleukin 1 receptor family journal Dev. Comp. Immunol. volume 28 issue 5 pages 415 28 year 2004 month May pmid 15062641 doi 10.1016 j.dci.2003.09.016 url issn ref ref name pmid17027517 cite journal author Boraschi D, Tagliabue A title The interleukin 1 receptor family journal Vitam. Horm. volume 74 issue pages 229 54 year 2006 pmid 17027517 doi 10.1016 S0083 6729 06 74009 2 issn ref Type 1 interleukin receptors Type 2 Type 2 interleukin receptors include ref name pmid15123776 cite journal author Donnelly RP, Sheikh F, Kotenko SV, Dickensheets H title The expanded family of class II cytokines that share the IL 10 receptor 2 IL 10R2 chain journal J. Leukoc. Biol. volume 76 issue 2 pages 314 21 year 2004 month August pmid 15123776 doi 10.1189 jlb.0204117 url issn ref Type 2 interleukin receptors Other Interleukin 1 receptor and interleukin 18 receptor belong to the immunoglobulin superfamily . Interleukin 8 receptor , RANTES receptors CCR1 , CCR3 , CCR5 , CCR1 MIP 1 receptor , CXCR4 PF4 receptor , Colony stimulating factor 1 receptor M CSF receptor and NAP 2 receptor belong to the chemokine receptor family. References Reflist External links MeshName Receptors, Interleukin Cytokine receptors Category Immunology membrane protein stub it Recettore delle interleuchine ... more details
Alpha subunits refers to several protein subunit s, e.g. G protein s Gi alphasubunit G sub i sub alphasubunit Gs alphasubunit G sub s sub alphasubunit Gq alphasubunit G sub q sub alphasubunit the pore forming loop of ion channel s disambig ... more details
, Sabatino G, Meneghini F, Stellin L, Verna N, Riccioni G, Theoharides TC title Interleukin28 and 29 IL 28 and IL 29 new cytokines with anti viral activities journal Int J Immunopathol Pharmacol volume ... IL 28, IL 29 and their class II cytokine receptor IL 28R journal Nat. Immunol. volume 4 issue 1 pages ...protein Name Interleukin 28A caption image width HGNCid 18364 Symbol IL28A AltSymbols , IFNL2 EntrezGene 282616 OMIM 607401 RefSeq NM 172138 UniProt Q8IZJ0 PDB ECnumber Chromosome 19 Arm q Band 13.13 LocusSupplementaryData protein Name Interleukin 28B caption image width HGNCid 18365 Symbol IL28B AltSymbols , IFNL3 EntrezGene 282617 OMIM 607402 RefSeq NM 172139 UniProt Q8IZI9 PDB ECnumber Chromosome 19 Arm q Band 13.13 LocusSupplementaryData Interleukin28 IL 28 is a cytokine that comes in two isoform s, IL 28A and IL 28B, and plays a role in immune defense against virus es, including the induction ... interferon type III interferon family of cytokines and are highly similar in amino acid sequence to interleukin ... type I IFNs are. Discovery IL 28 was discovered in 2003 by Zymogenetics ref name pmid12469119 cite ..., a second scan was performed to look specifically for cytokines. Both IL 28 and IL 29 were found in humans using this type of analysis. Structure IL 28 gene s are located near IL 29 on chromosome 19 in humans. The two isoforms of IL 28 IL 28A and IL 28B are 96 homologous, although differences in the functions between the two forms remains unclear. The receptor for IL 28 is composed of a unique IL 28Receptor Alpha chain which pairs with the IL 10Receptor Beta chain, leading many to classify IL 28 as a IL 10 like family member. Function IL 28 has also been shown to play a role in the adaptive immune .... Clinical significance Addition of IL 28 to vaccination results in 100 protection from a lethal ... only 50 of the time without IL 28. ref name pmid19304955 cite journal author Morrow MP, Pankhong ... References Reflist interleukins immunology stub sr 28 ... more details
. The cycle is completed by the hydrolysis of alphasubunit bound GTP to GDP, resulting in the re association of the alpha and beta gamma protein subunit subunits and their binding to the receptor ... G protein on the intracellular side of the Cell membrane membrane . The activated Receptor biochemistry receptor promotes the exchange of bound GDP for GTP on the G protein alphasubunit. GTP binding changes the Chemical conformation conformation of switch regions within the alphasubunit, which allows the bound trimeric G protein inactive to be released from the receptor, and to dissociate into active alphasubunit GTP bound and beta gamma protein dimer dimer . The alphasubunit and the beta ... of the G protein signal is controlled by the duration of the GTP bound alphasubunit, which ... membrane and to contribute to protein interactions. This family consists of the G protein alphasubunit ... Gs alphasubunit G S alpha , Gq alphasubunit G Q alpha , Gi alphasubunit G I alpha , transducin and G 12 alpha there are also fungus fungal and plant classes of alpha subunits. The alphasubunit ...Infobox protein family Symbol G alpha Name G alpha image PDB 1got EBI.jpg width caption heterotrimeric complex of a gt alpha gi alpha chimera and the gt beta gamma subunits Pfam PF00503 Pfam clan CL0023 ... protein proteins composed of three subunits alpha http www.ebi.ac.uk interpro IEntry?ac IPR001019 ... pages re3 year 2004 month February pmid 14762218 doi 10.1126 stke.2182004re3 url ref G proteins and their receptor biochemistry receptor s GPCRs form one of the most prevalent cell signalling signalling ... such as hormones and neurotransmitter s to a GPCR activates the Receptor biochemistry receptor by causing ... isoforms of each subunit, many of which have Splicing genetics splice variants, which together can make up hundreds of combinations of G proteins. The specific combination of Protein subunit subunits in heterotrimeric G proteins affects not only which T cell receptorreceptor it can Molecular ... more details
June pmid 18555777 doi 10.1016 j.cell.2008.03.038 url ref See also Interleukin 8 receptor, alphaInterleukin 8 receptorInterleukin 8 InterleukinInterleukinreceptor Cluster of differentiation G protein ...PBB geneid 3579 Interleukin 8 receptor, beta is a chemokine receptor . IL8RB is also known as CXCR2 , and CXCR2 is now the IUPHAR Committee on Receptor Nomenclature and Drug classification recommended ... CJ, Beckmann MP, Cerretti DP title Assignment of the genes encoding human interleukin 8 receptor types 1 and 2 and an interleukin 8 receptor pseudogene to chromosome 2q35 journal Genomics ... entrez cite web title Entrez Gene IL8RB interleukin 8 receptor, beta url http www.ncbi.nlm.nih.gov ... A, et al. title Molecular evolution of the human interleukin 8 receptor gene cluster. journal ... human interleukin 8 receptor types 1 and 2 and an interleukin 8 receptor pseudogene to chromosome 2q35 ... of a human interleukin 8 receptor. journal Science volume 253 issue 5025 pages 1278 80 year 1991 ... of complementary DNA encoding a functional human interleukin 8 receptor. journal Science volume 253 ... interleukin 8 receptor B gene. journal J. Biol. Chem. volume 269 issue 15 pages 11065 72 year 1994 ... activity enhances the phosphorylation of the class II interleukin 8 receptor in non hematopoietic ... distributed on multiple domains of human interleukin 8 receptor B. Determinants of high affinity ... MA, et al. title Receptor recognition and specificity of interleukin 8 is determined by residues that cluster ... peptide 78 are potent agonists for the type B, but not the type A, human interleukin 8 receptor ... 7 url ref Function The protein encoded by this gene is a member of the G protein coupled receptor family. This protein is a receptor for interleukin 8 IL8 . It binds to IL8 with high affinity, and transduces the signal through a G protein activated second messenger system. This receptor also binds ..., it binds ligands CXCL2 , CXCL3 , and CXCL5 . This receptor mediates neutrophil migration to sites ... more details
PDB ECnumber Chromosome 1 Arm p Band 13 LocusSupplementaryData G sub i sub alphasubunit or G sub i sub G sub 0 sub or Gi protein is a heterotrimeric G protein subunit that inhibits the production of Cyclic ... of the Gq alphasubunit G sub q sub alphasubunit . Types There are several types of G sub i sub ... Reflist External links MeshName Gi alphaSubunit biochem stub GTPases Intracellular signaling peptides ...protein Name GNAI1 guanine nucleotide binding protein G protein , alpha inhibiting activity polypeptide 1 caption image width HGNCid 4384 Symbol GNAI1 AltSymbols EntrezGene 2770 OMIM 139310 RefSeq NM 002069 UniProt P63096 PDB ECnumber Chromosome 7 Arm q Band 21 LocusSupplementaryData q22 protein Name GNAI2 guanine nucleotide binding protein G protein , alpha inhibiting activity polypeptide 2 caption ... nucleotide binding protein G protein , alpha inhibiting activity polypeptide 3 caption image ... or so from 3 to 16 alpha subunits plus betagamma dimers journal Biochim. Biophys. Acta volume 1768 ... url issn ref Receptors The following G protein coupled receptors couple to the G sub i sub subunit Acetylcholine Muscarinic acetylcholine receptor M2 M sub 2 sub & Muscarinic acetylcholine receptor M4 M sub 4 sub receptors Adenosine Adenosine receptor A1 A sub 1 sub & Adenosine receptor A3 A sub 3 ... Apelin receptors Calcium sensing receptor Chemokine CXCR4 receptor Dopamine Dopamine D2 receptor D sub 2 sub , Dopamine D3 receptor D sub 3 sub , Dopamine D4 receptor D sub 4 sub GABA B receptor GABA sub B sub receptor Glutamate mGluR2 mGluR sub 2 sub , mGluR3 mGluR sub 3 sub , mGluR4 mGluR sub 4 ... Histamine H3 receptor H sub 3 sub & Histamine H4 receptor H sub 4 sub receptors Melatonin MTNR1A MT sub 1 sub , MTNR1B MT sub 2 sub , & MTNR1C MT sub 3 sub receptors Opioid Delta Opioid receptor , Kappa Opioid receptor , Mu Opioid receptor , & Nociceptin receptor nociceptin receptors Prostaglandin PTGER1 EP sub 1 sub , PTGER3 EP sub 3 sub , FP receptor FP , & Thromboxane receptor TP receptors ... more details
PBB geneid 3557 The interleukin 1 receptor antagonist IL 1RA is a protein that in humans is encoded by the IL1RN ... The human interleukin 1 receptor antagonist IL1RN gene is located in the chromosome 2q14 region ... surface interleukin 1 receptor IL 1R . IL 1R is the same receptor that binds interleukin 1 IL 1 . Hence IL 1RA prevents IL 1 from sending a signal to that cell. Function IL 1RA is a member of the interleukin ... the activities of interleukin 1, alpha IL1A and interleukin 1, beta IL1B , and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related ... web title Entrez Gene IL1RN interleukin 1 receptor antagonist url http www.ncbi.nlm.nih.gov sites ... Osteoporotic fractures are associated with an 86 base pair repeat polymorphism in the interleukin 1 receptor antagonist gene but not with polymorphisms in the interleukin 1beta gene journal J. Bone Miner ... of the interleukin 1 receptor antagonist DIRA . ref name pmid19494218 cite journal author Aksentijevich ... of the Interleukin 1 Receptor Antagonist journal N. Engl. J. Med. volume 360 issue 23 pages ... j.1399 5618.2009.00757.x url ref An interleukin 1 receptor antagonist is used in the treatment of rheumatoid ... C title Interleukin 1 receptor antagonist role in biology journal Annu. Rev. Immunol. volume 16 ... 17035400 doi 10.1158 1055 9965.EPI 06 0267 refend External links MeshName Interleukin 1 Receptor ... P, Sim RB title The human IL 1 receptor antagonist gene IL1RN maps to chromosome 2q14 q21, in the region of the IL 1 alpha and IL 1 beta loci journal Genomics volume 13 issue 3 pages 654 7 year 1992 month ... by two independent laboratories. ref name dinarello cite journal author Dinarello CA title The interleukin ... Perrier S, Darakhshan F, Hajduch E. 2006 IL 1 receptor antagonist in metabolic diseases Dr Jekyll or Mr ... M, Fraumeni JF, Rabkin CS title Interleukin 1 polymorphisms associated with increased risk of gastric ..., Park HK, Chung JH title Impact of IL 1 receptor antagonist gene polymorphism on schizophrenia and bipolar ... more details
DISPLAYTITLE G sub q sub alphasubunit protein Name GNAQ guanine nucleotide binding protein G protein , q polypeptide caption image width HGNCid 4390 Symbol GNAQ AltSymbols EntrezGene 2776 OMIM 600998 RefSeq NM 002072 UniProt P50148 PDB ECnumber Chromosome 9 Arm q Band 21 LocusSupplementaryData protein Name GNA11 guanine nucleotide binding protein G protein , alpha 11 Gq class caption image width HGNCid 4379 Symbol GNA11 AltSymbols EntrezGene 2767 OMIM 139313 RefSeq NM 002067 UniProt P29992 PDB ECnumber Chromosome 19 Arm p Band 13.3 LocusSupplementaryData protein Name guanine nucleotide binding protein G protein , alpha 14 caption image width HGNCid 4382 Symbol GNA14 AltSymbols EntrezGene 9630 OMIM 604397 RefSeq NM 004297 UniProt O95837 PDB ECnumber Chromosome 9 Arm q Band 21 LocusSupplementaryData protein Name guanine nucleotide binding protein G protein , alpha 15 Gq class caption image width HGNCid 4383 Symbol GNA15 AltSymbols EntrezGene 2769 OMIM 139314 RefSeq NM 002068 UniProt P30679 PDB ECnumber Chromosome 19 Arm p Band 13.3 LocusSupplementaryData G sub q sub protein or G sub q 11 sub is a heterotrimeric G protein subunit that activates phospholipase C PLC . PLC in turn hydrolyzes ... mnemonic used in medical school to remember which receptor utilizes the G sub q sub subunit would ... . IP sub 3 sub then diffuses through the cytosol to bind to Inositol triphosphate receptor IP sub 3 ... modulatory neurotransmitter Receptor biochemistry receptors amine receptors belonging to rhodopsin family , G sub q sub is usually coupled to e.g. the G protein coupled receptor s 5 HT2 5 HT sub 2 sub 5 HT receptor serotonergic receptors Alpha 1 adrenergic receptor Vasopressin type 1 receptor Angiotensin II receptor type 1 Calcitonin receptor Histamine H1 receptor Metabotropic glutamate receptor , Group I Muscarinic acetylcholine receptor M1 M sub 1 sub , Muscarinic acetylcholine receptor M3 M sub 3 sub , and Muscarinic acetylcholine receptor M5 M sub 5 sub muscarinic receptors Genes GNAQ , gene ... more details
Interleukin 7 receptor IL7R also known as CD127 C luster of D ifferentiation 127 is a type I cytokine receptor . Category Human proteins Category Type I cytokine receptors ... more details
interleukin 1 receptor family journal J. Biol. Chem. volume 271 issue 10 pages 5777 5783 year 1996 ... Identification of two major sites in the type I interleukin 1 receptor cytoplasmic region responsible ... 4670 4678 year 2000 pmid 10671496 doi 10.1074 jbc.275.7.4670 ref Subfamilies Interleukin 1 receptor ... of receptor, perhaps through interactions with cytoskeletal elements. ref name PUB00005993 cite ... more details
PBB geneid 3554 Interleukin 1 receptor, type I IL1R1 also known as CD121a C luster of D ifferentiation 121a , is an interleukinreceptor . IL1R1 also denotes its human gene . ref name entrez cite web title Entrez Gene IL1R1 interleukin 1 receptor, type I url http www.ncbi.nlm.nih.gov sites entrez?Db ... text The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin 1 alpha IL1A , interleukin 1 beta IL1B , and interleukin 1 receptor antagonist IL1RA . It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II IL1R2 , interleukin 1 receptor like 2 IL1RL2 , and interleukin 1 receptor like 1 IL1RL1 form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. ref name entrez cite web title Entrez Gene IL1R1 interleukin 1 receptor, type I url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3554 accessdate ref Interactions Interleukin 1 receptor, type I has been ... of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein ... laydate quote pmc 24223 ref See also Cluster of differentiation Interleukin 1 receptor, type II ... CE, et al. title Cloning the interleukin 1 receptor from human T cells. journal Proc. Natl. Acad ... interleukin 1 receptor. journal Nucleic Acids Res. volume 17 issue 23 pages 10114 year 1990 pmid ... al. title The cell surface receptors for interleukin 1 alpha and interleukin 1 beta are identical ... BJ title Crystal structure of the type I interleukin 1 receptor complexed with interleukin 1beta. journal ... interaction with the interleukin 1 receptor and requirement in NFkappaB and AP 1 activation. journal ... receptor complex requires interleukin 1 receptor accessory protein. journal Proc. Natl. Acad. Sci. U.S.A. ... peptide bound to interleukin 1 receptor type 1. journal J. Biol. Chem. volume 275 issue 47 pages ... more details
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