irinotecan hydrochloride MedlinePlus a608043 pregnancy category D small Australia, United States ... data C 33 H 38 N 4 O 6 e molecular weight 586.678 Gram g Mole unit mol Irinotecan br 623.139 g mol Irinotecan hydrochloride br 677.185 g mol Irinotecan hydrochloride trihydrate smiles O C7OCC 6C O N2C ... correct chemspider StdInChIKey UWKQSNNFCGGAFS XIFFEERXSA N Irinotecan Camptosar, Pfizer Campto, Yakult Yakult Honsha is a drug used for the treatment of cancer. Irinotecan prevents DNA from unwinding ... consists of infusional 5 fluorouracil , leucovorin , and irinotecan. Irinotecan received accelerated ... appletter 1998 20571s8ltr.pdf ref . During development, it was known as CPT 11. Mechanism Irinotecan ... adverse effects of irinotecan are severe diarrhea and extreme suppression of the immune system. Diarrhea Irinotecan associated diarrhea is severe and clinically significant, sometimes leading to severe ... movement. Immunosuppression The immune system is adversely impacted by irinotecan. This is reflected ... while the bone marrow increases white cell production to compensate. Pharmacogenomics Irinotecan ... dose because their bodies are not able to clear irinotecan as fast as others. In studies this corresponds ... 1A1 gene predict the risk of severe neutropenia of irinotecan journal J. Clin. Oncol. volume 22 ... In 2005, the FDA made changes to the labeling of irinotecan to add pharmacogenomics recommendations, such that irinotecan recipients with a homozygous both of the two gene copies polymorphism in UGT1A1 ... irinotecan hydrochloride injection August 2010 http labeling.pfizer.com ShowLabeling.aspx?id 533 ref Irinotecan is one of the first widely used chemotherapy agents that is dosed according to the recipient ... glucuronosyltransferase UGT 1A1 and irinotecan practical pharmacogenomics arrives in cancer ... Camptothecin Topotecan Hycamtin Pharmacogenomics NK012 , a nanodevice formulation of SN 38 an irinotecan ... Pfizer website http www.pharmgkb.org do serve?objId PA2001&objCls Pathway Irinotecan Pathway on PharmGKB ... more details
orphan date November 2011 XELIRI is a chemotherapy regimen consisting of capecitabine trade name Xeloda combined with irinotecan . ref cite pmid 19386096 ref References reflist medicine stub Category Combination drugs ... more details
chembox Verifiedfields changed verifiedrevid 464385520 ImageFile SN 38.svg ImageSize IUPACName OtherNames 7 Ethyl 10 hydroxy camptothecin Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 94634 InChI 1 C22H20N2O5 c1 3 12 13 7 11 25 5 6 17 13 23 19 14 12 9 24 18 19 8 16 15 20 24 26 10 29 21 27 22 16,28 4 2 h5 8,25,28H,3 4,9 10H2,1 2H3 t22 m0 s1 InChIKey FJHBVJOVLFPMQE QFIPXVFZBM ChEMBL Ref ebicite correct EBI ChEMBL 837 StdInChI Ref stdinchicite correct chemspider StdInChI 1S C22H20N2O5 c1 3 12 13 7 11 25 5 6 17 13 23 19 14 12 9 24 18 19 8 16 15 20 24 26 10 29 21 27 22 16,28 4 2 h5 8,25,28H,3 4,9 10H2,1 2H3 t22 m0 s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey FJHBVJOVLFPMQE QFIPXVFZSA N CASNo Ref cascite changed ?? CASNo 86639 52 3 PubChem 104842 UNII Ref fdacite correct FDA UNII 0H43101T0J SMILES O C 1N4 C C C2 C 1COC O C 2 O CC c3nc5c c c3C4 CC cc O cc5 Section2 Chembox Properties Formula C sub 22 sub H sub 20 sub N sub 2 sub O sub 5 sub MolarMass 392.404 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition SN 38 is the active metabolite of irinotecan an analog of camptothecin a topoisomerase I inhibitor it is 1000 times more active than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN 38 relative to irinotecan varies from 2 to 2000 fold ref http labeling.pfizer.com ShowLabeling.aspx?id 533 ref . SN38 is metabolized via glucoronidation by UGT1A1 . The variant of UGT1A1 in 10 of Caucasians which leads to poor metabolization of Irinotecan predicts Irinotecan toxicity , as it cannot be excreted from the body in its SN 38 form. SN 38 is lost into the bile and feces. It can cause the symptoms of diarrhoea and myelosuppression experienced by 25 of the patients administered Irinotecan . Interactive pathway map IrinotecanPathway WP229 highlight SN 38 See also NK012 , a nanodevice formulation of SN 38 References reflist Category ... more details
IFL is a chemotherapy regimen for treatment of certain cancers, consisting of concurrent treatment with irinotecan , leucovorin folinic acid , and fluorouracil . It is similar to the FOLFIRI regimen and uses the same drugs. However, the flurouracil component is given as a bolus injection rather than as an infusion over 48 hours. See also Dose dense chemotherapy Chemotherapeutic Agents Category Chemotherapy regimens treatment stub ... more details
DISPLAYTITLE C sub 33 sub H sub 38 sub N sub 4 sub O sub 6 sub The molecular formula C sub 33 sub H sub 38 sub N sub 4 sub O sub 6 sub molar mass 586.67 g mol may refer to Irinotecan , a drug used for the treatment of cancer Phycoerythrobilin , a red phycobilin MolFormDisambig ... more details
FOLFIRI is a chemotherapy regimen for treatment of colorectal cancer . It is made up of the following drugs FOL folinic acid leucovorin , a vitamin B derivative used as a rescue drug for high doses of the drug methotrexate and that modulates potentiates reduces the side effects of fluorouracil F fluorouracil 5 FU , a pyrimidine analog and antimetabolite which incorporates into the DNA molecule and stops synthesis and IRI irinotecan Camptosar , a topoisomerase inhibitor, which prevents DNA from uncoiling and duplicating. Cetuximab , a monoclonal antibody to epidermal growth factor receptor , is sometimes added to FOLFIRI. ref NEJM 360 1408 ref The regimen consists of Irinotecan 180 mg m IV over 90 minutes concurrently with folinic acid 400 mg m or 2 x 250 mg m IV over 120 minutes . Followed by fluorouracil 400 500 mg m IV bolus then fluorouracil 2400 3000 mg m intravenous infusion over 46 hours . This cycle is typically repeated every two weeks. The dosages shown above may vary from cycle to cycle. Also see IFL chemotherapy Dose dense chemotherapy References Reflist Chemotherapeutic Agents DEFAULTSORT Folfiri Category Chemotherapy regimens antineoplastic drug stub de FOLFIRI ja FOLFIRI ... more details
NK012 is a nanodevice formulation of SN 38 an irinotecan metabolite . NK012 is an SN 38 releasing nanodevice constructed by covalently attaching SN 38 to the block copolymer PEG PGlu , followed by self assembly of amphiphilic block copolymers in aqueous media. ref http www.cancer.gov drugdictionary ?CdrID 574615 ref ref name Sumitomo2008 cite web url http cancerres.aacrjournals.org content 68 6 1631.abstract title Novel SN 38 Incorporated Polymeric Micelle, NK012, Strongly Suppresses Renal Cancer Progression year 2008 author Sumitomo et al. ref It has entered phase II clinical trials for triple negative breast cancer and relapsed small cell lung cancer ref http clinicaltrials.gov ct2 results?term NK012 ref . References reflist Category Experimental cancer drugs antineoplastic drug stub ... more details
Drugbox Verifiedfields changed verifiedrevid 470610217 image Monoclonal antibody data type mab mab type mab source zu o target TNFRSF10B TRAIL R2 Clinical data tradename pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled legal CA Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL, P, POM, CD, or Class A, B, C legal US OTC Rx only Schedule I, II, III, IV, V legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers CAS number Ref cascite changed ?? CAS number 918127 53 4 ATC prefix none ATC suffix PubChem DrugBank Ref drugbankcite correct drugbank DrugBank ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID NA Chemical data C 6406 H 9924 N 1716 O 2012 S 46 molecular weight 144.6 kDa Tigatuzumab CS 1008 is a monoclonal antibodies monoclonal antibody ref http www.who.int medicines services inn RL60prepublication.pdf WHO Drug Information ref for the treatment of cancer. as of 2009 10 , a clinical trial for the treatment of pancreatic cancer has been completed, ref National Cancer Institute NCI http www.cancernet.gov ncicancerbulletin 042109 page3 Combination Therapy Targets Pancreatic Cancer Stem Cells ref Phase II trials for colorectal cancer ref NCI http www.cancer.gov search ViewClinicalTrials.aspx?cdrid 654374&version HealthProfessional&protocolsearchid 6875774 CS 1008 Used With Irinotecan Versus Irinotecan Alone in Subjects With Metastatic Colorectal Carcinoma Who Failed First line Treatment With Oxaliplatin ref and non small cell lung cancer ref NCI http www.cancer.gov search ViewClinicalTrials.aspx?cdrid 657101&version HealthProfessional&protocolsearchid 6875774 CS 1008 With Carboplatin Paclitaxel in Chemotherapy na ve Subjects With Metastatic or Unresectable Non small Cell Lung Cancer NSCLC ref are running, and a study for ovarian cancer has been approved. ref NCI http www.cancer.gov sear ... more details
italic title taxobox name Happy tree image CancerTree.jpg image caption Cancer Tree, Camptotheca acuminata regnum Plantae unranked divisio Angiosperms unranked classis Eudicots unranked ordo Asterids ordo Cornales familia Cornaceae Nyssaceae genus Camptotheca genus authority Joseph Decaisne Decne. subdivision ranks Species subdivision Camptotheca acuminata br Camptotheca lowreyana Disputed date January 2010 The Happy Tree , Cancer Tree , or Tree of Life Camptotheca is a genus of medium sized deciduous tree s growing to 20 m tall, native to southern China and Tibet. They are usually included in the tupelo family Nyssaceae , but sometimes included with the tupelos in the dogwood family Cornaceae . Camptotheca is used to make Irinotecan , Topotecan , 9 Aminocamptothecin , and camptothecin 1 CPT 1 . It also contains trifolin and hyperoside . ref cite journal title Antifungal Activity of Camptothecin, Trifolin, and Hyperoside Isolated from Camptotheca acuminata author Li, S. Zhang, Z. Cain, A. Wang, B. Long, M. Taylor, J. journal Journal of Agricultural and Food Chemistry year 2005 volume 53 issue 1 pages 32 37 doi 10.1021 jf0484780 pmid 15631505 ref There are two species Camptotheca acuminata Decne. Camptotheca lowreyana S.Y.Li The name happy tree is a direct translation of the Chinese language Chinese name xi shu Simplified Chinese . An extract from the tree camptothecin is used as an anti cancer treatment. References reflist http web.archive.org web 20050115094522 http flora.huh.harvard.edu china mss volume13 Nyssaceae AGH coauthoring.htm Flora of China draft text Category Cornales Category Trees of China Asterid stub tree stub es Camptotheca ja pt Camptotheca zh ... more details
A, Hannah A, Rothenberg M title Phase I pilot study of SU5416 semaxinib in combination with irinotecan ... of Escalating Doses of the Tyrosine Kinase Inhibitor Semaxanib SU5416 in Combination with Irinotecan ... more details
File PDB 1ttg EBI.jpg thumb The tenth fibronectin type III domain human, PDB 1TTG File PDB 2rhe EBI.jpg thumb Variable domain of an antibody s lambda light chain human, PDB 2RHE Monobodies , also known as adnectins , are genetically engineered protein s that are able to bind to antigen s. Despite their name, they are not structurally related to antibodies , which makes them a type of antibody mimetic . They are being developed by Adnexus , a biotechnology company which has been part of Bristol Myers Squibb since 2007. The monobody angiocept CT 322 , a VEGF receptor receptor antagonist antagonist , has entered Phase II clinical trial s investigating the treatment of glioblastoma in October 2007. ref ClinicalTrialsGov NCT00562419 CT 322 in Treating Patients With Recurrent Glioblastoma Multiforme and Combination Therapy With Irinotecan ref ref name pmid19576999 cite journal author Bloom L, Calabro V title FN3 a new protein scaffold reaches the clinic journal Drug Discov. Today volume 14 issue 19 20 pages 949 55 year 2009 month July pmid 19576999 doi 10.1016 j.drudis.2009.06.007 url http linkinghub.elsevier.com retrieve pii S1359 6446 09 00219 0 ref It is also being studied for the treatment of other types of cancer, such as non small cell lung cancer ref ClinicalTrialsGov NCT00850577 Ph II of a Novel Anti angiogenic Agent in Combination With Chemotherapy for the Treatment of Non Small Cell Lung Cancer ref and colorectal cancer . ref ClinicalTrialsGov NCT00851045 Ph II Trial of a Novel Anti angiogenic Agent in Combination With Chemotherapy for the Second line Treatment of Metastatic Colorectal Cancer ref Structure Monobodies consist of 94 amino acids and have a molecular mass of about 10 kDa , fifteen times smaller than an IgG type antibody and comparable to the size of a single variable domain of an antibody. They are based on the structure of human fibronectin , more specifically on its tenth extracellular Fibronectin type III domain type III domain . This domain has ... more details
agent in patients who have failed oxaliplatin and irinotecan based therapy and who are intolerant to irinotecan. The positive opinion from the European regulatory agency, the Committee for Medicinal ... or irinotecan base therapy and who are intolerant to irinotecan. While there remains some ... more details
List of drugs I Iq Iv iq ir iquindamine International Nonproprietary Name INN Iquix iralukast International Nonproprietary Name INN iratumumab International Nonproprietary Name INN , United States Adopted Name USAN irbesartan International Nonproprietary Name INN Iressa irindalone International Nonproprietary Name INN irinotecan International Nonproprietary Name INN irloxacin International Nonproprietary Name INN irolapride International Nonproprietary Name INN iroplact International Nonproprietary Name INN irsogladine International Nonproprietary Name INN is isa ism isaglidole International Nonproprietary Name INN isalsteine International Nonproprietary Name INN isamfazone International Nonproprietary Name INN isamoltan International Nonproprietary Name INN isamoxole International Nonproprietary Name INN isavuconazole International Nonproprietary Name INN isaxonine International Nonproprietary Name INN isbogrel International Nonproprietary Name INN isbufylline International Nonproprietary Name INN iscotrizinol United States Adopted Name USAN iseganan United States Adopted Name USAN isepamicin International Nonproprietary Name INN Ismelin Ismo ismomultin alfa United States Adopted Name USAN Ismotic iso isoa isol isoaminile International Nonproprietary Name INN isobromindione International Nonproprietary Name INN isobutamben International Nonproprietary Name INN Isocaine isocarboxazid International Nonproprietary Name INN Isoclor isoconazole International Nonproprietary Name INN isocromil International Nonproprietary Name INN isoetarine International Nonproprietary Name INN isofezolac International Nonproprietary Name INN isoflupredone International Nonproprietary Name INN isoflurane International Nonproprietary Name INN Isohexal Hexal Australia & 91 Australia Au & 93 . Redirects to isotretinoin . isoleucine International Nonproprietary Name INN Isolyte isom isor isomazole International Nonproprietary Name INN isometamidium chloride International Nonproprietary Name ... more details
PBB geneid 23491 Carboxylesterase 3 is an enzyme that in humans is encoded by the CES3 gene . ref name pmid10518925 cite journal author Mori M, Hosokawa M, Ogasawara Y, Tsukada E, Chiba K title cDNA cloning, characterization and stable expression of novel human brain carboxylesterase journal FEBS Lett volume 458 issue 1 pages 17 22 year 1999 month Oct pmid 10518925 pmc doi 10.1016 S0014 5793 99 01111 4 ref ref name pmid14581373 cite journal author Sanghani SP, Quinney SK, Fredenburg TB, Sun Z, Davis WI, Murry DJ, Cummings OW, Seitz DE, Bosron WF title Carboxylesterases expressed in human colon tumor tissue and their role in CPT 11 hydrolysis journal Clin Cancer Res volume 9 issue 13 pages 4983 91 year 2003 month Oct pmid 14581373 pmc doi ref ref name pmid15100172 cite journal author Sanghani SP, Quinney SK, Fredenburg TB, Davis WI, Murry DJ, Bosron WF title Hydrolysis of irinotecan and its oxidative metabolites, 7 ethyl 10 4 N 5 aminopentanoic acid 1 piperidino carbonyloxycamptothecin and 7 ethyl 10 4 1 piperidino 1 amino carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3 journal Drug Metab Dispos volume 32 issue 5 pages 505 11 year 2004 month Apr pmid 15100172 pmc doi 10.1124 dmd.32.5.505 ref ref name entrez cite web title Entrez Gene CES3 carboxylesterase 3 brain url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 23491 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Carboxylesterase 3 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester and amide bond containing drugs such as cocaine and heroin. They also hydrolyze long chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined however, it is speculated that carboxylesterases may pla ... more details
of Irinotecan Neutropenia and Pharmacokinetics journal J. Clin. Oncol. volume 27 issue 16 pages 2604 ... colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan journal ... more details
Approach . 11 ed. 2008. ref today, topotecan and irinotecan . ref name M.E. Wall 1966 Cite journal ... CH sub 3 sub sub 2 sub align center OH align center H Irinotecan CPT 11, Camptosar align center CH sub 2 sub CH sub 3 sub align center H align center Image Irinotecan, position 10.png align center H ... more details
topoisomerase I inhibitors topotecan and irinotecan in induction which have been found to be effective ... chemotherapy regimen in 23 children which included irinotecan and gefitinib with 16 months of maintenance ... more details
s syndrome is associated with severe diarrhea and neutropenia in patients who are treated with irinotecan ... A, Del Rio E, G mez Pardo M, Baiget M title UGT1A1 gene variations and irinotecan treatment in patients ... more details
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