About the medical condition the webcomic Irritability webcomic Unreferenced date June 2009 Example farm date July 2010 SignSymptom infobox Name Irritability Image Caption DiseasesDB ICD10 ICD10 R 45 4 r 40 ICD9 ICD9 799.2 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Irritability is an excessive response to stimulus physiology stimuli . The term is used for both the physiological reaction to stimuli and for the pathology pathological , abnormal or excessive sensitivity to stimuli It is usually used to refer to anger or frustration . Irritability may be demonstrated in behavioral responses to both physiological and behavioral stimuli including environmental, situational, sociology sociological , and emotion al stimuli. Conditions Irritability can occur in people experiencing any of a variety of conditions, including colbegin Anxiety Alcoholism Anemia Asperger syndrome Autism Attention deficit hyperactivity disorder Bipolar disorder Borderline personality disorder Caesium Health and safety hazards Caesium toxicity Combat stress reaction Constipation Major depressive disorder Depression Diabetes Dysmenorrhea Fatigue medical Fatigue Fever Generalized anxiety disorder Headache Hunger Huntington s disease Hyperthermia Hyperthyroidism Hypothyroidism Hypoglycemia Insomnia Lead poisoning Mastoiditis Meningitis Menstrual cycle Obsessive compulsive disorder Opioids Opioids use Pain Parkinson s disease Pregnancy Premenstrual syndrome Psychological trauma Posttraumatic stress disorder Schizophrenia Sleep apnea Sleep deprivation Stimulant Stimulant drugs use stress medicine Stress Rabies Thyroid disease Withdrawal colend See also Wiktionary Annoyance Cognition, perception, emotional state and behaviour symptoms and signs emotion footer Category Symptoms and signs Cognition, perception, emotional state and behaviour Category Emotions med stub bg ca Irritabilitat biologia el es Irritabilidad biolog a pl Z o pt Irritabilidade ro Iritabilitate ... more details
, despite the often surreal nature of the strip, Irritability gives the impression of having a consistent ..., but fit into the Irritability continuity, an example being when Exoth was so lazy that he spent around ... irritability strips Mike draws Bad comics , quicker strips made in groups often with even more ... index1.html Irritability website. http maze.studio zoe.com comicpage index1.html Mirror of Irritability ... more details
Hallerian physiology was a theory competing with galvanism in Italy in the late 18th century. It is named after Albrecht von Haller , a Switzerland Swiss physician who is considered the father of neurology . The hallerians fundamental tenet held that muscular movements were produced by a mechanics mechanical force force, different from life and from the nervous system , and which operated beyond consciousness . The activity of this function could be controlled in dead and dissected animals by touching a metal knife to the muscle fiber or by a spark being discharged on them. The electricity operated only as a stimulus of irritability , and it was irritability which was the one, true cause of the contractions. Sources http ppp.unipv.it Collana Pages Libri Saggi NuovaVoltiana PDF quattro.pdf The Controversy on Animal Electricity in Eighteenth Century Italy Galvani, Volta and Others by Walter Bernardi Category Neurophysiology ... more details
wiktionary Cranky may refer to Irritability Cranky, a form of moving panorama performance operated by a crank Cranky Kong , a character from the Donkey Kong video game series Cranky the Crane , a character from the children s television series Thomas the Tank Engine and Friends Mr. Cranky , a satirical film critic personae since 1995 See also Kranky disambiguation Crank disambiguation disambig ja ... more details
expert subject 1 Medicine Hematology oncology task force date November 2011 Ornithinaemia is a blood disorder characterized by high levels of ornithine . Also known as hyperornithinemia, it may be associated with psychomotor retardation or epilepsy epileptic episodes. ref cite journal last Wright first T coauthors Pollitt, R title Psychomotor retardation, epileptic and stuporous attacks, irritability and ataxia associated with ammonia intoxication, high blood ornithine levels and increased homocitruline in the urine. journal Proceedings of the Royal Society of Medicine date 1973 Mar volume 66 issue 3 pages 221 pmid 4697977 ref References Reflist Category Blood disorders ... more details
Witzelsucht from the German witzeln, meaning to joke or wisecrack, and sucht , meaning addiction or yearning is a set of rare neurological symptoms characterized by the patient s uncontrollable tendency to make pun s, tell inappropriate jokes and pointless or irrelevant stories at inconvenient moments. The patient nevertheless finds these utterances intensely amusing. It is associated with small lesions of the orbitofrontal cortex . ref name jon05 It is distinguished from labile affect pathologic laughing by virtue of congruent affective experience and expression, and an admixture of irritability and mirth. It is most commonly seen in patients with frontal lobe disease or injury, particularly right frontal lobe tumors or trauma. See also Foerster s syndrome References reflist refs ref name jon05 cite journal first Mario F. last Mendez, M.D., Ph.D publisher The Journal of Neuropsychiatry and clinical neurosciences title Moria and Witzelsucht from Frontotemporal Dementia url http neuro.psychiatryonline.org cgi content full 17 3 429 year 2005 ref Category Neurology psych stub de Witzelsucht it Witzelsucht pl Moria psychiatria ... more details
Unreferenced auto yes date December 2009 Orphan date December 2009 Microcoria is a congenital disease in which the pupil s of the subject are narrower than 2mm in diameter. Microcoria is associated with juvenile onset glaucoma . It is also associated with Pierson syndrome chararacterized by microcoria and congenital nephrotic syndrome. The defect is in the Laminin beta 2 gene on chromosome 3p21 which encodes a protein essential to the glomerular basement membrane. ref Zenker et al., 2004. Zenker M., Aigner T., Wendler O., et al Human laminin beta 2 deficiency causes congenital nephrosis with mesangial sclerosis and distint eye abnormalities. Hum Mol Genet 2004 13 2625 2632 ref It is also part of the known manifestations of a born infant to a mother suffering from uncontrolled hyperglycemia Cn date November 2011 . Other symptoms include transposition of great vessels, respiratory distress secondary to surfactant defect, sacral agensis, jitteriness, irritability, and lethargy due to rebound fetal hypoglycemia. See also Miosis References reflist Category Diseases of the eye and adnexa Eye stub ... more details
Karolinska Scales of Personality KSP is a personality test. A newer version of the test is Swedish Universities Scales of Personality . KSP measures the personality with a 135 item questionnaire with answers on a four point Likert scale . The answers are grouped into 15 scales Psychic anxiety Somatic anxiety Muscular tension Psychasthenia Inhibition of aggression Detachment Impulsiveness Monotony avoidance sensation seeking Socialization Indirect aggression Verbal aggression Irritability Suspicion Guilt Social desirability KSP also exists in a Spanish version. ref Cite journal author Gener s Ortet, Manuel Ignacio Ib ez, Adri n Llerena & Rafael Torrubia title The Underlying Traits of the Karolinska Scales of Personality KSP journal European Journal of Psychological Assessment month August year 2002 volume 18 issue 2 pages 139&ndash 148 url http www3.uji.es ortet Documents KSP EJPA 2002 .pdf doi 10.1027 1015 5759.18.2.139 ref See also NEO PI R Temperament and Character Inventory References Reflist Category Personality tests ... more details
A serenic , or antiaggressive agent , is a type of drug which inhibits social feelings of irritability , aggression , and anger . Many commonly induce the opposite of effects as well, including empathy , compassion , and affection . A more powerful type of serenic which also produces prominent antidepressant , anxiolytic , and euphoriant effects is known as an entactogen , the classic example of which is the recreational drug MDMA Ecstasy , along with the other substituted methylenedioxy phenethylamine MDxx derivatives. Such agents have been known to induce feelings even as strong as love. Most serenics as well as entactogens are thought to work through the monoamine especially serotonin and oxytocin neurotransmitter systems. Examples of such agents include serotonergic s like serotonin reuptake inhibitor s SRIs , serotonin releasing agent s SRAs , and 5 HT1A receptor 5 HT sub 1A sub agonist s, as well as oxytocin receptor agonists, among others. In the future, serenics may someday be drug development developed and utilized in the clinical treatment of anger disorders. References Reflist 2 Unreferenced date October 2009 Serenics Category Psychoactive drugs nervous system drug stub ... more details
symptoms which are remarkably consistent with primary oral herpetic infection such as fever, irritability ... children under the age of three and young adults. There are prodromal symptoms fever, malaise, irritability ... more details
William Wallace Campbell Stellar Motions 1911 Max Verworn Irritability 1912 Svante Arrhenius Theory ... the preface to several books such as cite book title Irritability author Max Verworn year 1913 ... more details
Mad hatter disease describes the symptoms of mercury poisoning , specifically its effect on the nervous system . These include paraesthesias , vision and hearing impairment, slurred speech, anxiety, hallucinations, irritability, depression, lack of coordination, and tremors. The condition was observed among workers in the hat making industry in the 19th century. Chronic mercury element mercury exposure was common in hatter s who used a mercury solution during the process of curing animal pelts. Poor ventilation in the workshops of the time resulted in the hatters breathing in the fumes of this highly toxic metal, leading to an accumulation of mercury in the workers bodies. Metal toxicity was poorly understood and the broad range of symptoms were also associated with insanity . The phrase mad as a hatter may have been derived from the condition, and is commonly associated with Lewis Carroll s character the Mad Hatter in Alice s Adventures in Wonderland . While the character s eccentricities differ from those suffering from mercury poisoning the Hatter was likely inspired by Theophilus Carter , a furniture dealer , Lewis Carroll grew up near the town of Stockport , where hatting was the dominant trade. See also Korsakoff s syndrome Minamata disease References Unreferenced auto yes date December 2009 Reflist DEFAULTSORT Mad Hatter Disease Category Mercury poisoning de Hutmachersyndrom ... more details
Orphan date February 2009 In medicine, asthenization is a condition experienced by astronaut s following long term space flight , in which following return to Earth the astronaut experiences symptoms such as fatigue medical fatigue , irritability , lack of appetite and sleep disorder s. The condition s name derives from asthenia , which is a medical term denoting a feeling of weakness without actual loss of strength. It is suspected to be a psychosomatic effect of the result of overachieving astronauts no longer having a goal after becoming astronauts, or potentially a neurology neurological effect of microgravity . Buzz Aldrin , the second man to walk on the moon, was afflicted with this condition after returning from the moon. Citation needed date February 2007 See also Effect of spaceflight on the human body References cite journal title Asthenia Does It Exist in Space? author Nick Kanas, MD, Vyacheslav Salnitskiy, PhD, Vadim Gushin, MD, Daniel S. Weiss, PhD, Ellen M. Grund, MS, Christopher Flynn, MD, Olga Kozerenko, MD, Alexander Sled, MS and Charles R. Marmar, MD journal Psychosomatic Medicine url http www.psychosomaticmedicine.org cgi content full 63 6 874 date November 1, 2001 pmid 11719624 volume 63 issue 6 pages 874 80 cite web title Brain Oxygenation, Cerebral Blood and Liquor Dynamics in Cosmonauts during Space Flight url http tech db.istc.ru ISTC sc.nsf html pra.htm?open&id 2117 Category Human spaceflight Category Space medicine ... more details
String sign , or gastrointestinal string sign, is a medical term for a radiographic finding on an Upper GI series , in which the patient is given a radio opaque material, such as barium, to drink. X ray s are then taken of the patient s stomach and intestines. The gastrointestinal string sign represents a severe narrowing of loop of bowel, in which a thin stripe of contrast within the lumen looks like a string. It may be seen in Crohn s Disease , Pyloric stenosis Hypertrophic Pyloric Stenosis HPS , Carcinoid and Colon Cancer . In people with Crohn s Disease, the string sign is caused by incomplete filling of the intestinal lumen, which results from irritability and spasm associated with severe ulceration. In such cases, the string sign is most frequently seen at the terminal ileum. In infants with Hypertrophic Pyloric Stenosis HPS , the pylorus is narrowed and the radio opaque material will take on the appearance of a thin string as it passes through this narrowed channel. Often, there are several of these strings seen called the railroad track sign . The use of the Upper GI series for the diagnosis of HPS, which was the primary diagnostic tool for this condition in the 1980s and 1990s, has been largely replaced by the use of ultrasound , which is less invasive and can visualize the thickened pylorus, giving actual measurements of this thickening. References Nelson s Textbook of Pediatrics, Twelfth Edition. Richard Behrman, M.D. and Victor Vaughan, III, M.D. Editors, p. 904. Radiology 2007 242 632 633, 10.1148 radiol.2422041244 Category Gastroenterology ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 A39.2 4 ICD9 ICD9 036.2 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Meningococcal septicaemia or meningococcal septicemia , or meningococcaemia , is a form of sepsis , the causative organism being Neisseria meningitidis . ref cite web title Meningococcal publisher Meningitis Research Foundation date 2008 01 25 url http www.meningitis.org disease info types causes meningoccal disease accessdate 2008 01 28 ref It is caused by the release of toxins into the blood that break down the walls of blood vessel s. A rash can develop under the skin due to blood leakage that may leave red or brownish pin prick spots. ref cite web title Meningococcal septicaemia in college students publisher Essortment date 2002 url http ncnc.essortment.com meningitissepti ride.htm accessdate 2008 01 29 ref Signs and symptoms Fever Irritability Petechiae Headache Nausea and vomiting Altered mental status Shock circulatory Shock Purpura ref https health.google.com health ref Meningococcemia ref Prevention The effective vaccine against this is meningococcal vaccine . Notes reflist Category Bacterial diseases medical stub Gram negative proteobacterial diseases ... more details
Swedish Universities Scales of Personality SSP is a personality test based on the older Karolinska Scales of Personality KSP . ref Cite journal author J. P. Gustavsson , H. Bergman , G. Edman , L. Ekselius , L. von Knorring & J. Linder title Swedish universities Scales of Personality SSP construction, internal consistency and normative data journal Acta Psychiatrica Scandinavica volume 102 issue 3 pages 217 25 year 2000 month September pmid 11008858 doi 10.1034 j.1600 0447.2000.102003217.x ref It is originally in Swedish but has been translated to English. The personality profile is presented in t score mean 50 and standard deviation 10 . Both the SSP questionnaire and the scoring algorithm is free of charge. Personality dimensions SSP includes 91 items and yields 13 personality scales Somatic trait anxiety Psychic trait anxiety Stress susceptibility Lack of ascertiveness Impulsiveness Adventure Seeking Detachment Social Desirability Embitterment Trait Irritability Mistrust Verbal trait aggression Physical trait aggression References Reflist See also Revised NEO Personality Inventory Temperament and Character Inventory Category Personality tests ... more details
Hashitoxicosis , which can be abbreviated Htx , ref name pmid15812459 cite journal author Nabhan ZM, Kreher NC, Eugster EA title Hashitoxicosis in children clinical features and natural history journal J. Pediatr. volume 146 issue 4 pages 533 6 year 2005 month April pmid 15812459 doi 10.1016 j.jpeds.2004.10.070 url http linkinghub.elsevier.com retrieve pii S0022347604010674 ref is a transient hyperthyroidism caused by inflammation associated with Hashimoto s thyroiditis disturbing the thyroid follicle s, resulting in excess release of thyroid hormone . ref Robins Basic Pathology ref Symptoms main hyperthyroidism Major clinical signs include weight loss often accompanied by an increased appetite , anxiety , intolerance to heat , fatigue physical fatigue , hair loss, weakness, hyperactivity, irritability, apathy , clinical depression depression , polyuria , polydipsia , delirium , and sweating. Additionally, patients may present with a variety of symptoms such as palpitations and arrhythmia s notably atrial fibrillation , shortness of breath dyspnea , loss of libido , nausea , vomiting , and diarrhea . Long term untreated hyperthyroidism can lead to osteoporosis . In the elderly, these classical symptoms may not be present. See also Hashimoto s thyroiditis thyroid hormone hyperthyroidism References reflist Endocrine pathology Category Thyroid disease ... more details
The winter over syndrome is observed in inhabitants of research stations in Antarctica who winter over throughout the Antarctic winter. It consists of a variety of behavioral and medical disturbances, including irritability , Depression mood depression , insomnia and cognitive impairment . ref name onthice cite web url http www.sscnet.ucla.edu anthro bec papers Palinkas On The Ice.pdf title On the ice Individual and group adaptation in Antarctica author Palinkas LA accessdate 2011 11 04 ref Possible contributing causes of winter over syndrome include Stress biology stress , social isolation , subsyndromal seasonal affective disorder and polar T3 syndrome polar T sub 3 sub syndrome . ref name palinkas1997 cite web title Association between the Polar T sub 3 sub Syndrome and the Winter Over Syndrome in Antarctica url http www.nsf.gov pubs 1999 nsf98106 98106htm nsf98106h2.html author Palinkas LA, Reed HL, Do NV publisher Antarctic Journal of the United States Review 1997 year 1997 accessdate 2011 11 04 ref ref name onthice References reflist antarctica stub med stub Category Polar exploration Category Thyroid disease ... more details
its position in space Control of Motion sentience Irritability the movement of the agent is no longer given, but a reaction to elementary sensations or stimuli Control of Irritability Reflex different ... more details
taxobox name Bupleurum chinense regnum Plantae unranked divisio Angiosperms unranked classis Eudicots unranked ordo Asterids ordo Apiales familia Apiaceae or Umbelliferae genus Bupleurum species B. chinense binomial Bupleurum chinense Bupleurum chinense zh c p cha h j caai sup 4 sup wu sup 4 sup is a plant of the Apiaceae family. Ethnomedical uses Bupleurum Thorowax is a medicinal root found natively in East Asia. The Chinese name is Chai Hu . The leaves of the plant are long and thin and resemble fennel . Traditionally used to relieve infections with fever, hemorrhoids and indigestion. Also used to treat liver stagnation Qi , irritability, and liver disease. Bupleurum is a primary ingredient an ancient Chinese medicinal formula known as Xiao Chai Hu Tang, first recorded in the Treatise on Cold Induced Febrile Disease Shang Han Lun circa 280 AD. The ingredients are Bupleurum root 16 Paeonia lactiflora peony root 16 Pinellia ternata a rhizome 14 Zingiber officinale ginger rhizome 11 Zizyphus jujuba var. inermis jujube fruit 11 Panax ginseng Asian ginseng root 8 Scutellaria baicalensis Chinese skullcap root 8 Glycyrrhiza uralensis licorice 5 Another example of how Bupleurum is used in Traditional Chinese Herbal Medicine is in a formula called Xiao Yao San which was first seen in the Tai Ping Hui Min He Ji Ju Feng Imperial Grace Formulary of the Tai Ping Era 1078 85. In this formula traditional practitioners use this combination of herbs with emphasis on Bupleurum to soothe irritability. Bupleurum root Chai Hu 14 Angelica Sinensis Dang Gui 14 Peonia lactiflora root Bai Shao 14 Atractylodes Macrocephalae Rhizome Bai Zhu 14 Poria whole herb Fu Ling 14 Glycyrrhiza uralensis root honey fried 8 Herba Mentha leaf Bo He 8 Zingiber officinale Fresh rhizome Sheng Jiang 14 It is possible that Bupleurum, or Xiao Chai Hu Tang may reduce the symptoms of various types of hepatitis and HIV Citation needed date October 2008 though it may also increase the risk of liver damage. ... more details
Infobox disease Name Vitamin B sub 6 sub deficiency Image Pyridoxine structure ver2.svg Caption Pyridoxine DiseasesDB 13923 ICD10 ICD10 E 53 1 e 50 ICD9 ICD9 266.1 ICDO OMIM MedlinePlus eMedicineSubj med eMedicineTopic 1977 MeshID D026681 Pyridoxine deficiency also known as B sub 6 sub deficiency is a paediatric disease due to a lack of pyridoxine or vitamin B sub 6 sub . It usually becomes noticeable within the first 12 months of life in infants with a lack of pyridoxine, a coenzyme responsible for numerous essential metabolism metabolic reactions in humans. It is rarely observed, even in developing countries. ref name TCN cite book title Textbook of Child Neurology last Menkes first John H year 1980 publisher Henry Kimpton Publishers isbn 0 8121 0661 X ref ref name andrews Andrews Diseases of the Skin, 10th Edition, Elsevier. ref Symptoms The disease presents with several key symptoms including seizures , irritability , cheilitis inflammation of the lips , conjunctivitis and neurologic symptoms. In patients receiving isoniazid, pyridoxine deficiency can lead to a sideroblastic anemia because pyridoxine is a required cofactor in heme synthesis. Rare forms main pyridoxine dependent epilepsy Familial pyridoxine dependent epilepsy causes seizures at birth or shortly afterwards. It has been speculated that the cause of seizures in pyridoxine deficiency lies with abnormalities in the normal ratio of glutamic acid to GABA. ref name TCN Association is noted with ALDH7A1 gene. Irritability and other neurologic symptoms, such as confusion, are common place. ref name andrews Anemia has also been documented as a symptom. ref name TCN Causes The main cause of pyridoxine deficiency is a lack of pyridoxine in the diet. Another cause of vitamin B sub 6 sub deficiency is the use of the tuberculosis tuberculostatic medication isoniazid , and for this reason, it is usually replaced with vitamin B sub 6 sub whilst using this drug. ref name andrews Pathophysiology Decarboxylation of g ... more details
Image Leopoldo Marco Antonio Caldani.jpg thumb 250px Leopoldo Marco Antonio Caldani 1725 1813 was an Italy Italian anatomist and physiologist . ref http www.newadvent.org cathen 16016a.htm Leopoldo Marco Antonio Caldani Catholic Encyclopedia article ref Caldani was born in Bologna , Italy. He studied medicine in Bologna, receiving his degree in 1750, and became a professor of practical medicine in 1755. Caldani left to become professor of theoretical medicine at Padua, and in 1771 became professor of anatomy, retiring in 1805. He was a champion of Haller s theory of irritability and was noted for experimental studies on the function of the spinal cord and for the introduction of electricity in the physiology of the nerves. His most celebrated work is his anatomical atlas, in which he was aided by his nephew Floriano. He died in Padua , Italy in 1813. Works Sull intensivit et irritabilit di alune parti degli animali Bologna, 1757 Lettera sopra l irritabilit et insensivit Halleriana Bologne, 1759 Lettera sull uso del muschio nella idrofobia Venice, 1767 Esame del capitolo settimo dell ultima opera di Antonio de Haen Padua, 1770 Innesto felice del vajuolo Padua, 1768 Institutiones pathologicae Padua, 1772, 1776 Leyden, 1784 Venice, 1786 Naples, 1787 , translated into German by Reuss 1784 , and issued at Prague 1793 , in connection with Institutiones physiologicae Dialoghi di fisiologia e di pathologia Padua, 1778, 1793 Institutiones physiologicae Padua, 1773, 1778 Leyden, 1784 Venice, 1786 Naples, 1787 Institutiones semeioticae Padua, 1808 Icones anatomicae with 5 vols. of Explicatio iconum Venice, 1801 13 References references Persondata Metadata see Wikipedia Persondata . NAME Caldani, Leopoldo Marco Antonio ALTERNATIVE NAMES SHORT DESCRIPTION DATE OF BIRTH 1725 PLACE OF BIRTH DATE OF DEATH 1813 PLACE OF DEATH DEFAULTSORT Caldani, Leopoldo Marco Antonio Category 1725 births Category 1813 deaths Category Italian anatomists italy med bio stub it Leopoldo Marco Anto ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB 13184 ICD10 ICD10 E 05 2 e 00 ICD9 ICD9 242.3 ICDO OMIM MedlinePlus 000317 eMedicineSubj med eMedicineTopic 920 MeshID Toxic multinodular goitre also known as toxic nodular goitre , toxic nodular struma is a form of hyperthyroidism where there is excess production of thyroid hormones . It is characterized by functionally autonomous nodules. It emerges insidiously from nontoxic multinodular goitre. It is the second most common cause of hyperthyroidism after Graves disease in the developed world. In countries where the population is iodine deficient i.e. the developing world, iodine deficiency is the most common cause of hypothyroidism. Decreased iodine leads to decreased thyroid hormone. However, iodine deficiency can cause goitre thyroid enlargement within a goitre, nodules can develop. Symptoms Symptoms of toxic multinodular goitre are similar to that of hyperthyroidism , including heat intolerance muscle weakness wasting hyperkinesis tremor irritability weight loss osteoporosis increased appetite goitre swelling of the thyroid gland tachycardia high heart rate above 100 bpm at rest in adults Causes Sequence of events ref http emedicine.medscape.com article 120497 overview ref Iodine deficiency leading to decreased T4 production. Induction of thyroid cell hyperplasia due to low levels of T4. This accounts for the multinodular goitre appearance. Increased replication predisposes to a risk of mutation in the TSH receptor. If the mutated TSH receptor is constitutively active, it would then become toxic and produces excess T3 T4 leading to hyperthryoidism. Related eponym Plummer s disease is named after the American physician Henry Stanley Plummer but refers to a single toxic nodule adenoma which may present with the background of a suppressed multinodular goitre. ref WhoNamedIt2 synd 1094 Plummer s disease eponymously named after WhoNamedIt doctor 1074 Henry Stanley Plummer ref Footnotes references External links ... more details
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