Jaagsiekte yaag zeek te is a chronic and contagious disease of the lungs in sheep and goats first described in 1865. Its name derives from Afrikaans and means Chasing Sickness such that animals afflicted with the disease are in respiratory distress as if they are out of breath from being chased. It is also referred to as Ovine lung Pulmonary Adenocarcinoma OPA . During end stage disease, animals exude a foamy white fluid from the nose which is thought to be the mode of transmission between animals. Dissected lungs from afflicted sheep are interspersed with multifocal tumors . Some of these are small discrete Nodule medicine nodules and others will involve the entire half of a lung lobule. The disease is caused by a retrovirus called the Jaagsiekte Sheep Retrovirus Jaagsiekte Sheep Retrovirus JSRV that acutely transforms the lung epithelium epithelia into cancerous cells. Specifically, Type 2 pneumocytes and Clara cell Clara Cells of the lung are the likely target for JSRV transformation. The tumors formed there exhibit the overactive secretory functions which are a hallmark of OPA. OPA is an infectious disease of sheep and recently has been used as an animal model for human lung cancer. It is common in the UK and in South Africa . The disease has a long incubation period and is not seen until sheep reach at least 2 years of age. Clinical symptoms include weight loss, loss of appetite, and respiratory difficulty which is associated with obvious movement of the abdomen and high pitched noises. Fluid accumulates in the respiratory tract and the disease ultimately causes death. The retroviral ... of infected sheep. A common field assessment for Jaagsiekte is the wheelbarrow test where one ... somatic cell, was euthanized after it was confirmed that she had Jaagsiekte. ref Bridget M. Kuehn ...&itool pubmed docsum Transformation and oncogenesis by jaagsiekte sheep retrovirus. http jnci.oxfordjournals.org ... Sheep and goat diseases Category Animal virology veterinary med stub de Lungenadenomatose pl Jaagsiekte ... more details
Taxobox Color parameter is not needed automatically assigned name Jaagsiekte Sheep Retrovirus virus group vi familia Retroviridae subfamilia Orthoretrovirinae genus Betaretrovirus species Jaagsiekte sheep retrovirus Jaagsiekte sheep retrovirus JSRV is a betaretrovirus which is the causative agent of a contagious lung cancer in sheep called Jaagsiekte , or Ovine Pulmonary Adenocarcinoma Jaagsiekte OPA . Natural history JSRV is the virus that is the etiologic agent responsible for contagious lung tumors in sheep called Ovine Pulmonary Adenocarcinoma OPA .The disease was called Jaagsiekte , after the Afrikaans words for chase Jaag and sickness siekte , to describe the respiratory distress observed in an animal out of breath from being chased indicating the breathing difficulty that infected sheep have . Transmission of virus is through aerosol spread between sheep. Exogenous infectious form of JSRV has an endogenous counterpart which is present in the genomes of all sheep and goats. ref name York2003 York DF et al 2003 A history of ovine pulmonary adenocarcinoma jaagsiekte and experiments leading to the deduction of the JSRV nucleotide sequence. Curr Top Microbiol Immunol 275 1 23. PMID 12596893 ref The sheep genome has around 27 copies of endogenous retroviruses enJSRVs that are closely related to JSRV. Endogenous JSRV has several roles in the evolution of the domestic sheep as they are able .... ref name Leroux2007 Leroux C et al 2007 Jaagsiekte Sheep Retrovirus JSRV from virus to lung cancer ... et al. A history of ovine pulmonary adenocarcinoma jaagsiekte and experiments leading to the deduction ... lung tumors in sheep J Virol. 2006 Aug 80 16 8030 7. ref Palmarini et al Expression of the jaagsiekte ... reflist cite journal author Palmarini M, Fan H title Molecular biology of Jaagsiekte sheep retrovirus .... Microbiol. Immunol. volume 275 issue pages 55 79 year 2003 pmid 12596895 DEFAULTSORT Jaagsiekte Sheep ... Jaagsiekte Schaf Retrovirus ... more details
Taxobox Color parameter is not needed automatically assigned name Betaretrovirus virus group vi familia Retroviridae subfamilia Orthoretrovirinae genus Betaretrovirus type species Mouse mammary tumor virus subdivision ranks Species subdivision Jaagsiekte sheep retrovirus br Langur virus br Mason Pfizer monkey virus br Mouse mammary tumor virus br Squirrel monkey retrovirus A betaretrovirus is a genus of the retroviridae family biology family . It has type B retrovirus type B or type D retrovirus type D Morphology biology morphology . The type B is common for a few exogenous, vertically transmitted and endogenous viruses of mouse mice some primate and sheep viruses are the type D. Examples are the mouse mammary tumour virus , enzootic nasal tumour virus ENTV 1, ENTV 2 , and simian retrovirus types 1, 2 and 3 SRV 1, SRV 2, SRV 3 ref name pmid16515713 cite journal author Philipp Staheli J, Marquardt T, Thouless ME, Bruce AG, Grant RF, Tsai CC, Rose TM title Genetic variability of the envelope gene of Type D simian retrovirus 2 SRV 2 subtypes associated with SAIDS related retroperitoneal fibromatosis in different macaque species journal Virol J volume 3 pages 11 date March 6 year 2006 pmid 16515713 doi 10.1186 1743 422X 3 11 pmc 1450265 ref . References Reflist External links http www.expasy.org viralzone all by species 66.html Viralzone Betaretrovirus Retroviruses Category Betaretroviruses Virus stub es Betaretrovirus it Betaretrovirus zh ... more details
Wiktionary opa Opa OPA OPA may refer to TOC right Government Office of the Pardon Attorney , an agency of the United States Department of Justice Office of Price Administration , a United States government office set up by President Roosevelt to stabilize prices and rents after the outbreak of World War II Ontario Power Authority , a government agency in Canada International agreements Ouagadougou Peace Agreement, that put an end to the Ivorian Civil War Outward Processing Arrangement , a trade agreement between Hong Kong and mainland China Laws Obscene Publications Act 1959 , an Act of Parliament in the United Kingdom Oil Pollution Act of 1990 , a United States law Medicine Oropharyngeal airway , a device used to keep the upper respiratory airway open Out patient appointments Ovine Pulmonary Adenocarcinoma, a disease of the lungs in sheep and goats, also known as Jaagsiekte Music OPA song OPA song , a song by Giorgos Alkaios & Friends competing in the Eurovision Song Contest 2010 for Greece Opa Opa , a song by Notis Sfakianakis, later covered by both Antique and Despina Vandi Opa band , Uruguayan jazz group Opa Opa , an alternative name to the album Mera Me Ti Mera album Mera Me Ti Mera by Antique Sports FC OPA , association football club from Oulu, Finland Other Oligo Pool Assay , a SNP genotyping platform from Illumina Online Privacy Alliance , a coalition of Internet companies Opa programming language , a web development platform Open Platform Architecture , a software interface from Ericsson Mobile Platforms for use internally in cellular phones Optical parametric amplifier , a method to amplify laser light Oracle Policy Automation , an enterprise applications suite Ordre des Palmes Academiques , an Order of Chivalry of France for academics and cultural and educational figures Oregon Potters Association , not for profit group of clay artists Opa, the nickname of Dorus Rijkers , Dutch lifeboat captain who rescued over 500 people in the course of his career OPA, ... more details
GPI anchored cell surface receptor for jaagsiekte sheep retrovirus, the envelope ... of epithelial cells by jaagsiekte sheep retrovirus journal Proc. Natl. Acad. Sci. U.S.A. volume ... more details
Infobox disease Name Lung cancer Image cancerous lung.jpg Caption Cross section of a human lung. The white area in the upper lobe is cancer the black areas are discoloration due to Tobacco smoking smoking . DiseasesDB 7616 ICD10 ICD10 C 33 c 30 ICD10 C 34 c 30 ICD9 ICD9 162 ICDO OMIM MedlinePlus 007194 eMedicineSubj med eMedicineTopic 1333 eMedicine mult eMedicine2 med 1336 eMedicine2 emerg 335 eMedicine2 radio 807 eMedicine2 radio 405 eMedicine2 radio 406 MeshID D002283 Lung cancer is a disease characterized by uncontrolled cell growth in tissue biology tissues of the lung . If left untreated, this growth can spread beyond the lung in a process called metastasis into nearby tissue and, eventually, into other parts of the body. Most cancers that start in lung, known as primary lung cancers, are carcinomas that derive from epithelium epithelial cells. Worldwide, lung cancer is the most common cause of cancer related death in men and women, and is responsible for Category Deaths from lung cancer 1.3 million deaths annually, as of 2004. ref name WHO The most common symptom s are shortness of breath, coughing including Hemoptysis coughing up blood , and weight loss. ref name Harrison The main types of lung cancer are small cell lung cancer SCLC , also called oat cell cancer, and non small cell lung cancer NSCLC . The most common cause of lung cancer is long term exposure to tobacco smoking tobacco smoke . ref name Merck Nonsmokers account for 15 of lung cancer cases, ref name Thun and these cases are often attributed to a combination of genetics genetic factors , ref name Gorlova ref name Hackshaw radon gas, ref name Catelinois asbestos , ref name O Reilly and air pollution ref name Kabir ref name Coyle ref name Chiu including passive smoking secondhand smoke . ref name AUTOREF ref name AUTOREF1 Lung cancer may be seen on chest radiograph and computed tomography CT scan . The medical diagnosis diagnosis is confirmed with a biopsy . This is usually performed by bronchosc ... more details
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