- Phospholipid scramblase
apoptotic pathways. Nuclear localisation sequence File 1Y2A.png thumb Structure of mouse Karyopherin ... of scramblase PLSCR1 complexed to Karyopherin alpha 2 importin was determined using X ray diffraction ... more details
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- KPNA6
last5 Cerami first5 A last6 Bukrinsky first6 M cite journal author Gallay P title Role of the karyopherin ... more details
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- RCC1
requires a specific nuclear localization sequence receptor, karyopherin alpha3 Qip journal J ... G, Yaseen NR title The nucleoporin Nup98 is a site for GDP GTP exchange on ran and termination of karyopherin ... more details
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- NUP214
author Yaseen NR, Blobel G title Cloning and characterization of human karyopherin beta3. journal ... pmc 20743 cite journal author Bonifaci N, Moroianu J, Radu A, Blobel G title Karyopherin ... more details
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- Ran (biology)
of proteins across the nuclear envelope by interacting with karyopherin s and changing their ability ... title Exportin 5, a novel karyopherin, mediates nuclear export of double stranded RNA binding proteins ... karyopherin beta2 Ran x GppNHp journal Nature journal Nature volume 399 issue 6733 pages 230 7 publisher ... Aurelian year 2002 month October title Karyopherin beta 2B participates in mRNA export from the nucleus ... more details
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- Nucleoporin 62
9102465 doi 10.1006 jmbi.1996.0801 ref Karyopherin beta2 transportin , a riboprotein transporter ... and characterization of human karyopherin 3 journal Proc. Natl. Acad. Sci. U.S.A. volume 94 issue ..., Blobel G title Cloning and characterization of human karyopherin 3 journal Proc. Natl. Acad. Sci. U.S.A. ... more details
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- Nuclear transport
The entry and exit of large molecules from the cell nucleus is tightly controlled by the nuclear pore complex es NPCs . Although small molecules can enter the nucleus without regulation, ref name Watson cite book last Watson first JD coauthors Baker TA, Bell SP, Gann A, Levine M, Losick R. title Molecular Biology of the Gene publisher Peason Benjamin Cummings CSHL Press. date 2004 edition 5th chapter Ch9 10 isbn 0805396039 ref macromolecules such as RNA and proteins require association with karyopherin s called importin s to enter the nucleus and exportin s to exit. Protein that must be imported to the nucleus from the cytoplasm carry nuclear localization signal s NLS that are bound by importins. A NLS is a sequence of amino acids that acts as a tag. They are diverse in their composition and most commonly hydrophilic , although hydrophobic sequences have also been documented. ref name Watson Proteins, transfer RNA , and assembled ribosome ribosomal subunits are exported from the nucleus due to association with exportins, which bind signaling sequences called nuclear export signal s NES . The ability of both importins and exportins to transport their cargo is regulated by the small Ras related GTPase , Ran biology Ran . GTPases are enzymes that bind to a molecule called guanosine triphosphate GTP which they then hydrolyze to create guanosine diphosphate GDP and release energy. Ran is in a different conformation depending on whether it is bound to GTP or GDP. In its GTP bound state, Ran is capable of binding karyopherins importins and exportins . Importins release cargo upon binding to RanGTP, while exportins must bind RanGTP to form a ternary complex with their export cargo. The dominant nucleotide binding state of Ran depends on whether it is located in the nucleus RanGTP or the cytoplasm RanGDP . File Rancycle nuclearimport nuclearexport.png 550px thumb Macromolecule s, such as RNA and protein s, are active transport actively transported across the nuclear membrane ... more details
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- NXF1
month Oct. title Karyopherin beta 2B participates in mRNA export from the nucleus journal PNAS Proc ... more details
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- RECQL
format accessdate laysummary laysource laydate quote ref and Karyopherin alpha 2 . ref name pmid9168958 ... more details
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- RPL23
of human karyopherin 3 journal Proc. Natl. Acad. Sci. U.S.A. volume 94 issue 9 pages 4451 6 year 1997 ... more details
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- ITK (gene)
format accessdate laysummary laysource laydate quote ref Karyopherin alpha 2 , ref name pmid11581171 ... kinase Itk and interaction of its SH3 domain with karyopherin alpha Rch1alpha journal Int. Immunol ... more details
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- XPO1
url language format accessdate laysummary laysource laydate quote pmc 140238 ref See also Karyopherin ... more details
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- Heterogeneous nuclear ribonucleoprotein A1
S0969 2126 97 00211 6 cite journal author Bonifaci N, Moroianu J, Radu A, Blobel G title Karyopherin ... more details
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- UBR5
bibcode oclc id url language format accessdate laysummary laysource laydate quote ref and Karyopherin ... more details
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- Inner nuclear membrane proteins
called laminopathies. ref cite journal doi 10.1038 nature05075 title Karyopherin mediated ... more details
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- HMGA2
by an interaction between its second AT hook and Karyopherin alpha 2 importin 2 . ref name Cattaruzzi ... more details
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- SGK
format accessdate laysummary laysource laydate quote pmc 1171384 ref Karyopherin alpha 2 , ref ... more details
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- ILF3
PBB geneid 3609 Interleukin enhancer binding factor 3 is a protein that in humans is encoded by the ILF3 gene . ref name pmid7519613 cite journal author Kao PN, Chen L, Brock G, Ng J, Kenny J, Smith AJ, Corthesy B title Cloning and expression of cyclosporin A and FK506 sensitive nuclear factor of activated T cells NF45 and NF90 journal J Biol Chem volume 269 issue 32 pages 20691 9 year 1994 month Sep pmid 7519613 pmc doi ref ref name pmid8885239 cite journal author Matsumoto Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM title Identification of novel M phase phosphoproteins by expression cloning journal Mol Biol Cell volume 7 issue 9 pages 1455 69 year 1997 month Jan pmid 8885239 pmc 275994 doi ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Nuclear factor of activated T cells NFAT is a transcription factor required for T cell expression of interleukin 2. NFAT binds to a sequence in the IL2 enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. The encoded protein, which is primarily localized to ribosomes, probably regulates transcription at the level of mRNA elongation. At least three transcript variants encoding three different isoforms have been found for this gene. ref name entrez cite web title Entrez Gene ILF3 interleukin enhancer binding factor 3, 90kDa url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3609 accessdate ref Interactions ILF3 has been shown to Protein protein interaction interact with XPO5 , ref name pmid11777942 cite journal last Brownawell first Amy M authorlink coauthors Macara Ian G year 2002 month Jan. title Exportin 5, a novel karyopherin, mediates nucle ... more details
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- Callystatin A
to the cytoplasm by binding to a karyopherin protein called chromosome region maintenance ... more details
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- IRF1
K, Katayama I, Kaneda Y title Differential regulation of karyopherin alpha 2 expression by TGF ... more details
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- Cell nucleus
by a family of transport factors known as karyopherin s. Those karyopherins that mediate movement ... karyopherin s called importin s to enter the nucleus and exportin s to exit. Cargo proteins ... more details
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- Mir-155
protein DGCR8 . Pre miRNA leaves the nucleus into the cytoplasm carried by the enzyme Karyopherin exportin ... more details
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- MicroRNA
in a process involving the nucleocytoplasmic shuttle XPO5 Exportin 5 . This protein, a member of the karyopherin ... more details
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