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Encyclopedia results for Kell antigen system

Kell antigen system





Encyclopedia results for Kell antigen system

  1. Paul Kell

    Paul Ernest Kell July 8, 1915 &ndash May 1977 was a player in the National Football League . Biography Kell was born on July 8, 1915 in Princeton, Illinois . ref http www.pro football reference.com players K KellPa20.htm ref Career Kell was drafted by the Green Bay Packers in the eighth round of the 1939 NFL Draft and played two seasons with the team. As such, he was a member of the 1939 NFL Champion Packers. That season he was also named to the National Football Conference Western Conference Pro Bowl team. He played at the collegiate level at the University of Notre Dame . ref http www.nfl.com players paulkell careerstats?id KEL033222 ref See also List of Green Bay Packers players References reflist Persondata Metadata see Wikipedia Persondata . NAME Kell, Paul ALTERNATIVE NAMES SHORT DESCRIPTION DATE OF BIRTH July 8, 1915 PLACE OF BIRTH DATE OF DEATH 1977 PLACE OF DEATH DEFAULTSORT Kell, Paul Category 1915 births Category 1977 deaths Category People from Princeton, Illinois Category Green Bay Packers players Category Western Conference Pro Bowl players Category Notre Dame Fighting Irish football players Amfoot bio stub ...   more details



  1. Tn antigen

    Technical date December 2011 Tn antigen refers to the oligosaccharide in fact monosaccharide structure N acetylgalactosamine GalNAc linked to serine or threonine by a glycosidic bond , i.e. as an Glycan O Linked glycans O glycan . It is not usually found on healthy Cell biology cell surfaces, but may be found on cancer cells. ref I. Brockhausen, H. Schachter, P. Stanley, Essentials of Glycobiology, 2nd edition. A. Varki, R. Cummings, J. Esko, Eds, Cold Spring Harbor NY Cold Spring Harbor Laboratory Press 2009. Chapter 9, O GalNAc Glycans ref Addition of single monosaccharide residues creates disaccharide antigens the Thomsen Friedenreich antigen TF antigen or T antigen is formed by substitution with galactose Gal b1 3 GalNAc the sialyl Tn antigen STn antigen is formed by substitution with sialic acid Neu5Ac a2 6 GalNAc. Further substitution gives the normal core structures and O glycans found on healthy cell surfaces. References Reflist Category Articles created via the Article Wizard Category Oncology Category Immune system ...   more details



  1. Kell Osborne

    Refimprove date August 2010 Infobox musical artist See Wikipedia Wikiproject opera name Kell Osborne birth date Birth date 1939 3 12 birth place Birmingham, Alabama , U.S. death date death date and age 2012 1 29 1939 3 12 death place origin Los Angeles, California , U.S. instrument Vocals occupation Singer years active 1955 2012 genre Rhythm and Blues R&B , Soul music soul label Trey, Atlantic Records Atlantic , Class, Capitol Records Capito l, Revis, Warner Bros. Records Warner Bros. , Mercury records Mercury , Universal Records Universal associated acts The Primes background solo singer Kell Osborne March 12, 1939 January 29, 2012 was an American singer best known as a member of The Primes ... Temptations year 2002 isbn 0 8154 1218 5 page 30 ref Early years Kell Osborne was born in Birmingham ... cite web title You Can t Outsmart A Woman The Kell Osborne Story url http www.soul source.co.uk index.php articles.html soul articles you cant outsmart a woman the kell osbor r1954 publisher SoulSource ... Diana Ross Diane later Diana Ross , Florence Ballard , Mary Wilson , and Betty McGlown . In 1960 Kell ... soulsource Career Kell singned with Lester Sill and Lee Hazelwood s Trey label, and Phil Spector became ... releasing an album of new material with some initial interest shown by Universal Records . Kell Osborne has made many contributions to music over the years. Kell Osbourne died on 29 January 2012 ... date accessdate 2012 02 10 ref ref cite web url http www.soul source.co.uk soul news kell osborne passes on r2343 title Kell Osborne passes on publisher Soul source.co.uk date accessdate 2012 02 ... kell osborne Kell Osborne at AOL music http www.artistdirect.com nad music card 0,,1584676,00.html Kell Osborne at artistdirect.com http www.soulwalking.com Respect.html Kell Osborne at www.soulwalking.com Persondata Metadata see Wikipedia Persondata . NAME Osborne, Kell ALTERNATIVE NAMES SHORT ... 29, 2012 PLACE OF DEATH DEFAULTSORT Osborne, Kell Category African American musicians Category ...   more details



  1. Troy Kell

    Troy Michael Kell born June 13, 1968 ref http corrections.utah.gov services offender search.html ref is an inmate on death row in Utah . Troy Kell was sentenced to life in prison by the State of Nevada ... State Prison as part of a prisoner exchange program. On July 6, 1994, Troy Kell attacked and killed ... Blackmon a total of 67 times while his associate, Eric Daniels, held Blackmon down. Kell was sentenced to death by firing squad for his part in the murder. Once in prison, Kell became a white supremacist ... on Blackmon, Kell had been involved in race related altercations with several black inmates, including ... tells the story of Troy Kell and Eric Daniels murder of Lonnie Blackmon, and shows footage of the initial trial in 1996 statements from Kell, Daniels, guards, the state attorney, Blackmon s brother, and Sandra Shaw who was serving time elsewhere as the instigator of Kell s first murder, for which Kell was originally incarcerated and footage of the attack captured by the CCTV within the Utah Prison in Gunnison, Utah. The trial Due to security concerns, the state won the right to hold Kell s trial ... chose to file an appeal. As of May 2008, Kell remains on death row , as his appeals process continues. Conviction for a previous murder Kell was originally imprisoned in the state of Nevada ... and Toronto for drug smuggling, all using the same alias, Kelly. In 1986, Kell, then age 18, was asked ... at that time, which caused Shaw to turn to Kell, her childhood protector from her old neighborhood. Cotton Kelly drove into the desert with Shaw, Kell, and a third young man William Billy Merritt , where Kell shot Kelly six times in the face, killing him. The murder was dubbed the Show and Tell ... which led to the arrests and convictions of Shaw, Kell, and Merritt. Years later, Fletcher ... testified against Kell, was released from prison after serving only 4 years of an 8 to 12 year, plea ... serving life in prison without parole. Troy Kell was sentenced to life in prison without parole. He ...   more details



  1. Reginald Kell

    Kell c. 1950s Reginald Clifford Kell 8 June 1906 spaced ndash 5 August 1981 was an English clarinetist ... artist. Kell was influential as one of the first clarinettists to employ continuous vibrato to enhance ... appointments at his alma mater , the Royal Academy of Music in London. In 1948 Kell moved to the United ... Benny Goodman . Career Early years Born in York , England, Kell was awarded a scholarship to the Royal ... Weston, Pamela. http www.oxfordmusiconline.com subscriber article grove music 14841 Kell, Reginald ... the LPO in 1936 and was succeeded as first clarinet by Bernard Walton . ref name dg Kell was Arturo ... to his orchestral work Kell taught at the Royal Academy between 1935 and 1939, and played in chamber ... L on Goossens . Kell s contemporary Jack Brymer was another pioneer of vibrato on the clarinet, but came to prominence later than Kell. Inspired by the great singers with whom he came in contact, notably Kirsten Flagstad , Kell sought to emulate their warm expressive sounds on the clarinet. ref ... the Second World War Kell was principal clarinettist of the Royal Liverpool Philharmonic Liverpool ... Jenkins, p. 214 ref When Walter Legge founded the Philharmonia Orchestra in 1945 Kell became its principal clarinettist. At its first concert, conducted by Beecham, Kell was the soloist in Wolfgang ... played few concerts, working mostly in the recording studio, Kell was able to serve as principal ... Kell gave up both positions he was succeeded at the Philharmonia by Walton, ref http www.oxfordmusiconline.com ... subscription ref and at the Royal Philharmonic by Brymer. ref Lucas, p. 319 ref Later years Kell moved ... teacher, his best known pupil being Benny Goodman , who approached him for lessons in 1948 49. Kell ... who ruined our Benny Goodman. Goodman persisted and Kell accepted him as a student in 1952 and taught ... Benny 20Goodman 1.htm Benny Goodman and Reginald Kell , Jazz Professional , accessed 12 February 2012 ref Kell s other pupils included the soloist and conductor Alan Hacker , ref name dg and Peanuts ...   more details



  1. Kell on Earth

    Infobox television show name Kell On Earth image caption show name 2 format Reality television starring Kelly Cutrone country United States language English num seasons 1 num episodes 8 executive producer Billy Taylor, Dan Cutforth , Jane Lipsitz , Kelly Cutrone producer Magic Elves Productions editor location runtime 44 minutes company channel Bravo US TV network Bravo first aired start date 2010 2 01 last aired present status Airing website http www.bravotv.com kell on earth Kell on Earth is an United States American Reality television reality docudrama starring Kelly Cutrone , the founder of the public relations , Brand management branding and marketing firm People s Revolution . ref April 2003. http www.workinpr.com industry research pra indwatch apr03.asp Industry Watch Entertainment FashionKelly Cutrone, Owner, The People s Revolution , Workinpr. Retrieved on April 11, 2008. ref ref Neyfakh, Leon 2009 03 30 . http www.observer.com 2009 media kelly cutrone writing girls guide life and power harpercollins Kelly Cutrone Writing Girls Guide to Life and Power For HarperCollins HTML . The New York Observer . The New York Observer, LLC. April 5, 2009. ref The series premiered on February ... prnewser pop culture ratings spindustry premiere crushes kell on earth 152736.asp title Ratings SPINdustry Premiere Crushes Kell On Earth accessdate 2010 03 16 ref align center 2 The Show Must Go On February ..., 2010 url http www.mediabistro.com prnewser pop culture ratings spindustry premiere crushes kell on earth 152736.asp title Ratings SPINdustry Premiere Crushes Kell On Earth accessdate 2010 03 16 ref align center 3 Highway to Kell February 15, 2010 Nicolas Petrou align center 372,000 ref cite web publisher ... premiere crushes kell on earth 152736.asp title Ratings SPINdustry Premiere Crushes Kell On Earth ..., 2010 DKNY align center 756,000 References Reflist External links imdb title id 1594402 title Kell on Earth ... Category 2010s American television series pt Kell on Earth ...   more details



  1. Kevin and Kell

    and Kell image Deleted image removed Image KevinAndKell.png 250px deletable image caption 1 Sunday, July 19, 2009 caption The Dewclaws, protagonists of Kevin and Kell . Clockwise from upper left Kevin, Kell, Lindesfarne, Coney and Rudy. author Bill Holbrook url http www.kevinandkell.com rss atom ... 3, 1995 genre Furry Comedy rating preceded by followed by Kevin and Kell is a furry fandom furry ... kk0903.html title The first strip publisher Kevin and Kell date 1995 09 03 accessdate 2009 07 29 ... between a rabbit, Kevin Dewclaw Kevin and a grey wolf , Kell Dewclaw. In their society, their major difference is their diet Kevin is a herbivore and Kell is a carnivore . Their family includes three ... Kell s first marriage and their only biological child Coney, a carnivorous rabbit. ref name About ... and Kell publisher Kevin and Kell accessdate 2007 11 09 ref The comic s plot revolves around species related humor, satire, and interpersonal conflict. Kevin and Kell receives over three million page ...? publisher The Unofficial Kevin and Kell FAQ date 2007 09 06 accessdate 2008 01 05 ref ref name Toonpedia cite web last Markstein first Don url http www.toonopedia.com kevnkell.htm title Kevin and Kell ... Award Winners 2003 publisher Ursa Major Awards accessdate 2007 11 09 ref Setting Kevin and Kell takes ... title What is the Great Bird Conspiracy GBC ? publisher The Unofficial Kevin and Kell FAQ date 2007 09 06 accessdate 2007 01 08 ref The society in Kevin and Kell rather than identifying people by race ... and Kell date 1998 02 02 accessdate 2007 12 02 ref There is also a Wild where civilized animals can .... Rudy is running away from civilization. publisher Kevin and Kell date 1997 06 12 accessdate ... Shopping. The grocery stores are different. publisher Kevin and Kell date 1997 07 17 accessdate ... crosses over publisher Kevin and Kell date 2003 10 11 accessdate 2007 11 18 ref ref cite web last ... is in charge. publisher Kevin and Kell date 2003 10 12 accessdate 2007 11 18 ref However, she ...   more details



  1. Vernon Kell

    Infobox spy name Sir Vernon Kell nickname K image caption allegiance United Kingdom File Flag of the United Kingdom.svg 20px service MI5 serviceyears 1909 1940 rank Director General of MI5 operation award ... Intelligence officer , Soldier Major General Sir Vernon George Waldegrave Kell , Order of the British ... in 1873, Kell was the son of Major Waldegrave Kell of the 38th Foot and his wife, Georgiana Augusta ... and his English wife. After graduating from Royal Military Academy Sandhurst Sandhurst , Kell was commissioned ... to London from China in 1902 Kell was employed as a German intelligence analyst at the War Office ... Kell was selected by the War Office and the Admiralty as one of two officers, alongside Mansfield ... intelligence concerns thusly Kell took responsibility for domestic concerns, whilst Cumming was to oversee ... Intelligence Service now commonly known as Mi5 and Mi6 respectively . During World War I, Kell ... , called MI5 g . Among Kell s officers worked ex ICS officers Robert Nathan Indian civil servant ... name Popplewell220 Harvnb Popplewell 1995 p 220 ref In May 1940 Kell was removed from office by Winston ... output world war 2.html ref Kell was the longest serving head of any UK government department ... output Page369.html accessdate 2008 10 28 ref Awards Kell was awarded the following awards Officer ... of the Bath Order of Saint Lazarus ref Portrait photograph of Kell at Plate 1 of Christopher ... photograph of Kell at Plate 1 of Christopher Andrew s Authorised History of MI5 partly obscured ref Notes Kell was a major character in Bert Coules radio adaptation of Sir Arthur Conan Doyle s His ... all his publications. Kell convinces Holmes to join the War Effort to seek out the mastermind of a German ... Persondata Metadata see Wikipedia Persondata . NAME Kell, Vernon ALTERNATIVE NAMES SHORT DESCRIPTION ... March 1942 PLACE OF DEATH DEFAULTSORT Kell, Vernon Category British people of Polish descent Category ... Army personnel of the Boxer Rebellion pl Vernon Kell ...   more details



  1. Rob Kell

    Orphan date February 2009 John Robert Rob Kell , Order of the British Empire CBE 1902 1983 was an England English civil engineer with particular expertise in the field of HVAC heating, ventilation and air conditioning . Kell joined the firm of Oscar Faber & Partners in 1926, after a period as a contractor, and rose to become a Partner in 1948. In 1936 he co wrote the standard textbook Heating and air conditioning of Buildings with Oscar Faber. He also wrote the entry on heating, ventilation and air conditioning for the Encyclopaedia Britannica . He was responsible for the building services design for the Bank of England , including on site electricity generation with waste heat recovery and the 12 acre Earls Court Exhibition Centre , notably the special ventilating jet nozzles International Heating and Ventilation Engineering IHVE Journal, March 1938 . He also designed the air conditioning for the rebuilt Palace of Westminster House of Commons 1943 1950 , and the heating systems for numerous notable buildings including St Paul s Cathedral and St Albans Cathedral . He was president of IHVE in 1952, made CBE in 1966, awarded the IHVE Gold Medal in 1967. Rob Kell lived in St Albans and was educated at St Albans School Hertfordshire St Albans School . He was married to Pamela and they had one son, Paul, now a theatre lighting designer. He had a long association with St Albans Cathedral, which he served for many years in various volunteer capacities, and has the unusual distinction shared with Robert Runcie of having his bust carved in stone among the Abbey s roof gargoyles. Sources http www.hevac heritage.org hall of fame heating & ventilating heating & ventilating.htm HEVAC hall of fame Persondata Metadata see Wikipedia Persondata . NAME Kell, Rob ALTERNATIVE NAMES SHORT DESCRIPTION DATE OF BIRTH 1902 PLACE OF BIRTH DATE OF DEATH 1983 PLACE OF DEATH DEFAULTSORT Kell, Rob Category English civil engineers Category English non fiction writers Category 1902 births Category ...   more details



  1. Richard Kell

    Infobox football biography image playername Richard Kell fullname Richard Kell height dateofbirth birth date and age 1979 9 15 df y cityofbirth Bishop Auckland countryofbirth England currentclub Jet2.com clubnumber position Midfielder. youthyears1 youthclubs1 years1 1998 2001 years2 2001 years3 2001 years4 2001 2005 years5 2005 2006 years6 2006 years7 2006 2007 clubs1 Middlesbrough F.C. Middlesbrough clubs2 Torquay United F.C. Torquay loan clubs3 Torquay United F.C. Torquay clubs4 Scunthorpe United F.C. Scunthorpe United clubs5 Barnsley F.C. Barnsley clubs6 Scarborough F.C. Scarborough clubs7 Lincoln City F.C. Lincoln City clubs8 Total caps1 0 caps2 4 caps3 11 caps4 83 caps5 2 caps6 2 caps7 1 caps8 103 goals1 0 goals2 1 goals3 2 goals4 8 goals5 0 goals6 0 goals7 0 goals8 11 Richard Kell born September 15, 1979 in Bishop Auckland is an England English footballer playing as a midfielder. He has broken his leg twice in his career. Kell began his career as a junior with Middlesbrough F.C. Middlesbrough , turning professional in July 1998 and soon becoming a regular in the reserve side at the Riverside Stadium. After failing to break into the first team, he joined Torquay United F.C. Torquay United , initially on loan on February 7, 2001, making his league debut 3 days later, scoring in the 2 1 win against Lincoln City F.C. Lincoln City at Sincil Bank. The move was made permanent with a free transfer on the 9th of March, Kell signing a contract until the end of the season. For the remainder of the 2000 01 season, his qualities greatly enhanced a midfield which had particularly missed ... under the new manager Roy McFarland . However, 5 days later Kell decided that his future lay elsewhere .... Kell has now retired from football through injury, although he is starting to get back into football ... 2280464,00.html References soccerbase id 24059 Persondata Metadata see Wikipedia Persondata . NAME Kell ... PLACE OF BIRTH Bishop Auckland , England DATE OF DEATH PLACE OF DEATH DEFAULTSORT Kell, Richard Category ...   more details



  1. Trevor Kell

    Kell, Trevor ALTERNATIVE NAMES SHORT DESCRIPTION Canadian ice hockey player DATE OF BIRTH June 23 ... OF DEATH DEFAULTSORT Kell, Trevor Category 1986 births Category Albany Devils players Category Canadian ... Trenton Devils players Canada icehockey winger 1980s stub simple Trevor Kell ...   more details



  1. Antigen presentation

    Unreferenced date October 2009 Technical date October 2009 Antigen presentation is a process in the body s immune system by which macrophages , dendritic cells and other cell types capture antigen s and then enable ... MeshName antigen presentation immune system DEFAULTSORT Antigen Presentation Category Immune system ... thumb 350px In the upper pathway foreign protein or antigen 1 is taken up by an antigen presenting cell 2 . The antigen is processed and displayed on a MHC II molecule 3 , which interacts ... 5 and presented to B lymphocytes 6 , which process 7 and present antigen on MHC II 8 to a previously activated T helper cell 10 , spurring the production of antigen specific antibodies 9 . The host ... immune system to survey for infection requires specialized pathways of enabling recognition of pathogen derived antigens by T cells. Antigen recognition Unlike B cells , T cells fail to recognize antigens in the absence of antigen presentation, with the important exception of the superantigen ... leukocyte antigen HLA . Most cells are capable of presenting antigens and activating the adaptive response. Some cells, however, are specially equipped to acquire and present antigen, and to prime ..., and also act as professional antigen presenting cells APC . These professional APCs are equipped ... in which the antigen was first encountered by the APC. Intracellular antigens Class I Image Antigen presentation.svg thumb 240px right Antigen presentation stimulates T cells to become either cytotoxic ... , into small peptide s. A specialized carrier, the Transporter associated with Antigen Processing ... surface. MHC Class I molecules present antigen to CD8 cytotoxic T cell s. With the exception of some ... antigen complex is then recognized by T cells passing through the lymph node. Exogenous antigens ... conditions. See also Immune system Immunology Immunological synapse Trogocytosis External links ... Antigen 20Processing 20and 20Presentation&displayType 1 ImmPort Gene summaries, ontologies, pathways ...   more details



  1. Kell Brook

    Infobox Boxer name Kell Brook image Replace this image male.svg only free content images are allowed for depicting living people see WP NONFREE realname Ezekial Brinsly Reid nickname Kid, Special K, Special One weight Welterweight height reach nationality English birth date birth date and age 1986 05 ... 0 draws 0 no contests KO 18 Ezekiel Brinsly Reid , better known as Kell Brook , born 3 May 1986 ref http boxrec.com list bouts.php?cat boxer&human id 272717 Kell Brook Boxer Bot generated title ref ... www.boxrec.com list bouts.php?human id 272717&cat boxer Boxrec Kell Brook professional record ref ... latest news 756 one kell of an interview.html ref Professional career Brook s first fight as a professional ... The championship fight at London s York Hall saw Kell Brook take on Welshman Barrie Jones for the vacant ... Kell Brook wants Michael Jennings ref Young boxer of the year On 25 September 2009, Brook pipped fellow ... test says Kell Brook Daily Express Fight against Jennings is biggest test says Brook ref Finally .... Kell won the fight in round 5 following a bad cut above the eye sustained by Jennings which ... hi boxing 9008888.stm BBC Sport Kell Brook cuts Micheal Jennings to win fight ref On 9 December 2010 ... Welterweight Champion On 17 March 2012, Kell Brook took his undefeated run to 27 fights by beating ... to be there. ref http www.bbc.co.uk sport 0 boxing 17418872 Kell Brook beats Matthew Hatton to win ... buzzing to have joined the outfit. Hearn said that he was excited about adding Kell to our stable ... turned professional trainer. Speaking of Brook he said Kell oozes class and has that something special ... hottest prospect kell brook signs.htm Matchroom Boxing Britains hottest prospect joins Matchroom ref ... story 98109.html ESPN Kell Brook comes of age by outpointing Lovemore N Dou ref Professional boxing ..., Kell ALTERNATIVE NAMES SHORT DESCRIPTION Boxer DATE OF BIRTH 3 May 1986 PLACE OF BIRTH United Kingdom Britain DATE OF DEATH PLACE OF DEATH DEFAULTSORT Brook, Kell Category English boxers Category ...   more details



  1. CDw17 antigen

    Context date March 2009 CDw17 antigen is a lactosylceramide . ref MeshName CDw17 antigen ref A4GALT acts upon it. References Reflist DEFAULTSORT Cdw17 Antigen Category Lipids biochem stub ...   more details



  1. Antigen processing

    07 167 494 75 oclc doi External links MeshName Antigen Processing Category Immune system it Processazione ...Antigen processing is a biological process that prepares antigen s for antigen presentation presentation to special cells of the immune system called T cell T lymphocytes . This process involves two distinct pathways for processing of antigens from an organism s own self proteins or intracellular pathogen s e.g. virus es , or from phagocytosis phagocytosed pathogens e.g. bacteria subsequent presentation of these antigens on major histocompatibility complex MHC class I class I or major histocompatibility complex MHC class II class II MHC molecules is dependent on which pathway is used. Both Major histocompatibility complex MHC class I and II are required to bind antigen before they are stably expressed on a cell surface. While the conventional distinction between the two pathways is useful, there are instances where extracellular derived peptides are presented in the context of MHC class I and cytosolic peptides are presented in the context of MHC class II this often happens in dendritic cells . The Endogenous Pathway The endogenous pathway is used to present cellular peptide fragments on the cell surface on MHC class I molecules. If a virus had infected the cell, viral peptides would also be presented, allowing the immune system to recognize and kill the infected cell. Worn out proteins within the cell become ubiquitin ated, marking them for proteasome degradation. Proteasomes break the protein up into peptides that include some around nine amino acids long suitable for fitting within the peptide binding cleft of MHC class I molecules . Transporter associated with antigen presenting ... Pathway The exogenous pathway is utilized by specialized antigen presenting cell s to present peptides ... of MHC class I. See also Major histocompatibility complex MHC T cell Cross presentation Antigen presenting cell Antigen presentation Polyclonal response References references cite book author Richard ...   more details



  1. Somatic antigen

    A somatic antigen is an antigen located in the cell wall of a gram positive or gram negative bacterium . ref somatic antigen. The American Heritage Medical Dictionary. 2007. Houghton Mifflin Company 29 Aug. 2010 http medical dictionary.thefreedictionary.com somatic antigen ref references See also Lipopolysaccharide DEFAULTSORT Somatic Antigen Category Bacterial proteins Category Bacteriology bacteria stub ...   more details



  1. Tumor antigen

    Tumor antigen is an antigen ic substance produced in tumor Cell biology cells , i.e., it triggers an immune response in the Host biology host . Tumor antigens are useful in identifying tumor cells and are potential candidates for use in cancer therapy . Mechanism of tumor antigenesis Normal protein s in the body are not antigenic because of self tolerance , a process in which self reacting cytotoxic T lymphocyte s CTLs and autoantibody producing B lymphocytes are culled centrally in primary lymphatic tissue BM and peripherally in secondary lymphatic tissue mostly thymus for T cells and spleen lymph nodes for B cells . Thus any protein that is not exposed to the immune system triggers an immune response. This may include normal proteins that are well sequestered from the immune system, proteins that are normally produced in extremely small quantities, proteins that are normally produced only ... structure due to mutation can act as a tumor antigen. Such abnormal proteins are produced due to mutation ... in melanoma cells. Oncofetal antigen s are another important class of tumor antigens. Examples are alphafetoprotein AFP and carcinoembryonic antigen CEA . These proteins are normally produced in the early stages of embryonic development and disappear by the time the immune system is fully developed ... s may also have an abnormal structure in tumor cells and could thus be targets of the immune system .... class wikitable Tumor antigen Tumor in which it is found Remarks Alphafetoprotein AFP Germ cell tumor s Hepatocellular carcinoma Carcinoembryonic antigen CEA bowel cancer s Occasional lung or breast cancer CA 125 Ovarian cancer MUC1 MUC 1 breast cancer epithelial tumor antigen ETA breast cancer ... Melanoma associated antigen MAGE malignant melanoma Also normally present in the testis abnormal ... importantly, tumor antigens can be used in cancer therapy as cancer vaccine tumor antigen vaccines ... abstract 87 23 9498 Vaccination Against Tumor Cells Expressing Breast Cancer Epithelial Tumor Antigen ...   more details



  1. Heterophile antigen

    Orphan date February 2009 Heterophile antigens certain antigen of similar nature, if not identical present in different Tissue biology tissues in different biological species, classes or kingdoms. Composition chemically these are lipoprotein polysaccharide complex , possibly there are identical chemical groupings in the structure of ucopolysaccharid s and lipid s. Example Forssman antigen , cross reacting microbial antigen so antibodies to these antigens produced by one species cross react with antigen of other species. Category Immunology Microbiology stub pl Antygen heterofilny ...   more details



  1. Macrophage-1 antigen

    External links MeshName Macrophage 1 antigen Complement system Cell adhesion molecules Integrins membrane ...Macrophage 1 antigen or integrin alphaMbeta2 is a complement receptor CR3 consisting of CD11b and CD18 . ref cite journal author Todd R title The continuing saga of complement receptor type 3 CR3 journal J. Clin. Invest. volume 98 issue 1 pages 1 2 year 1996 pmid 8690779 doi 10.1172 JCI118752 pmc 507390 ref It binds to C3b and C4b . Function Complement receptor 3 CR3 CD11b CD18 is a human cell surface receptor found on polymorphonuclear leukocytes mostly neutrophils , NK cells , and mononuclear phagocytes like macrophages . CR3 is a pattern recognition receptor , capable of recognizing and binding to many molecules found on the surfaces of invading bacteria. CR3 also recognizes complement system iC3b when bound to the surface of foreign cells. Binding to the receptor causes phagocytosis and destruction of the foreign cell. CR3 belongs to a family of cell surface receptors known as integrin s because they share this particular chain, they are referred to as 2 integrins , which are extremely widely distributed throughout nature and which generally are important in cellular adhesion and cell cell interactions in a variety of cells and circumstances. Upregulation of MAC 1 in the presence of certain factors such as Il 2 may cause a prolongation of the life of the immune cell while the presence of TNF alpha induces apoptosis and selective removal of the cell. A fully activated neutrophil may express on its membrane 200,000 or more CR3 molecules. Absence of CR3 results in reduced binding and ingestion of Mycobacterium tuberculosis in mice. In human mononuclear phagocytes, phagocytosis of Mycobacterium tuberculosis is mediated in part by human monocyte complement receptors including CR3. ref cite journal author Schlesinger LS, Bellinger Kawahara CG, Payne NR, Horwitz MA. title ... Synonyms and abbreviations CR3 CD11b CD18 Macrophage 1 antigen Mac 1 See also Macrophage References ...   more details



  1. Oncofetal antigen

    Orphan date April 2012 Oncofetal antigens are protein s which are typically present only during fetus fetal development but are found in adults with certain kinds of cancer . These proteins are often measurable in the blood of individuals with cancer and may be used to both diagnose and follow treatment of the tumors. One example of an oncofetal antigen is alpha fetoprotein , which is produced by hepatocellular carcinoma and some germ cell tumor s. Another example is carcinoembryonic antigen , which is elevated in people with colon cancer and other tumors. Other oncofetal antigens are trophoblast glycoprotein precursor ref 37 kiloDalton oncofetal antigen protein and immature laminin receptor protein are identical, universal T cell inducing immunogens on primary rodent and human cancers. Anticancer Res. 1999 Nov Dec 19 6C 5535 42. PMID 10697612 ref and immature laminin receptor protein also known as oncofetal antigen protein . Oncofetal antigens are promising targets for vaccination against several types of cancers. External links http www.ncbi.nlm.nih.gov entrez viewer.fcgi?db protein&val 73621980 Entrez protein entry for trophoblast glycoprotein precursor www,quantumimmunologics.com References Reflist Category Proteins ca Antigen oncofetal es Ant geno oncofetal ...   more details



  1. Antigen Shift

    . This recording used piano and synthesized melodies. In 2006, Antigen Shift s second full length album, The Way of the North , was released on Ad Noiseam . Also in 2006, Antigen Shift playing several ... was joined in the group by Jairus Khan of Ad ver sary . In the summer of 2010 it was announced that Antigen ... will be performing as part of an Ad ver sary . Antigen Shift collaborative set at this year s Kinetic ... Of The North CD, 2006 External links http www.discogs.com artist Antigen Shift Antigen Shift at discogs.com ...   more details



  1. Hemolytic disease of the newborn (anti-Kell)

    anti Kell sub 1 sub is caused by a mismatch between the Kell antigen system Kell antigens of the mother and fetus. About 91 of the population are Kell sub 1 sub negative and about 9 are Kell sub 1 sub positive. A fraction of a percentage are homozygous for Kell sub 1 sub . Therefore, about 4.5 of babies born to a Kell sub 1 sub negative mother are Kell sub 1 sub positive. The disease results when maternal antibodies to Kell sub 1 sub are transferred to the fetus across the placenta placental barrier ... Coombs test Hematology Hemolytic anemia Kell antigen system HDN DEFAULTSORT Hemolytic Disease Of The Newborn ... for the Kell sub 1 sub antigen develop antibodies after being exposed to red blood cells that are positive for Kell sub 1 sub . Over half of the cases of hemolytic disease of the newborn owing the anti Kell antibodies are caused by multiple blood transfusions, with the remainder due to a previous pregnancy with a Kell sub 1 sub positive baby. Prevention Suggestions have been made that women of child bearing age or young girls should not be given a Blood transfusion transfusion with Kell sub 1 sub positive blood. Donated blood is not currently screened in the U.S.A. for the Kell blood ...Infobox disease Name HDN due to anti Kell alloimmunization ICD10 ICD10 P 55 8 p 50 ICD9 ICD9 773.2 Hemolytic disease of the newborn anti Kell sub 1 sub is the second most common cause of severe hemolytic diseases of newborn s HDN after Rh disease . Anti Kell sub 1 sub is becoming relatively more important ... gestation. Hydrops fetalis can also occur early. The finding of anti Kell antibodies in an antenatal ... anti Kell sub 1 sub antibody injections would prevent sensitization to RBC surface Kell sub 1 sub ... disease , but the methods for IgG anti Kell sub 1 sub antibodies have not been developed at the present ... disease of the newborn anti K is similar to the management of Rh disease . anti Kell sub 2 sub , anti Kell sub 3 sub and anti Kell sub 4 sub antibodies Hemolytic disease of the newborn can also ...   more details



  1. CD59 antigen

    Cd59 Antigen Category Protein domains Category Membrane proteins ...   more details



  1. Carcinoembryonic antigen

    . In humans, the carcinoembryonic antigen family consists of 29 genes, 18 of which are normally ... Seminars in Cancer Biology year 1999 title The carcinoembryonic antigen CEA family structures, suggested ... S ref The following is a list of human genes which encode carcinoembryonic antigen related cell ... Antigen Clusters of differentiation Cell adhesion molecules Tumor markers Category Tumor markers Category IgSF ca Antigen carcinoembrionari de Carcinoembryonales Antigen es Ant geno carcinoembrionario fr Antig ne carcino embryonnaire id Antigen karsinoembrionik it Antigene carcino embrionale nl Carcino embryonaal antigen ja pl Antygen rakowo p odowy ro Antigen carcinoembrionar fi Karsinoembryonaalinen ...   more details



  1. CD36 antigen

    Orphan date June 2011 Pfam box Symbol CD36 Name CD36 family image width caption Pfam PF01130 InterPro IPR002159 SMART Prosite SCOP TCDB OPM family OPM protein PDB CD36 antigen is a transmembrane , highly glycosylated , glycoprotein expressed by monocytes , macrophages , platelets, microvascular endothelial cells and adipose tissues. CD36 recognises oxidized low density lipoprotein , long chain fatty acid s, anionic phospholipid s, collagen types I, IV and V, thrombospondin and Plasmodium falciparum infected erythrocyte s. ref name PUB00003034 cite journal author Crombie R, Silverstein R title Lysosomal integral membrane protein II binds thrombospondin 1. Structure function homology with the cell adhesion molecule CD36 defines a conserved recognition motif journal J. Biol. Chem. volume 273 issue 9 pages 4855 4863 year 1998 pmid 9478926 doi 10.1074 jbc.273.9.4855 ref CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at Protein Reviews On The Web http mpr.nci.nih.gov prow . Subfamilies Adhesion molecule CD36 InterPro IPR005428 Lysosome membrane protein II InterPro IPR005429 Human proteins containing this domain CD36 SCARB1 SCARB2 References reflist InterPro content IPR002159 DEFAULTSORT Cd36 Antigen Category Protein domains Category Protein families Category Membrane proteins membrane protein stub ...   more details




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