File Kinesin walking.gif thumb Animation of kinesin walking on a microtubule Image Kinesin cartoon.png thumb The kinesin dimer attaches to, and moves along, microtubules. Image Motility of kinesin en.png thumb Diagram illustrating motility of kinesin. A kinesin is a protein belonging to a class of motor ... 10.1016 S0092 8674 03 00111 9 ref The founding member of this superfamily, kinesin 1, was isolated ... of a novel force generating protein, kinesin, involved in microtubule based motility journal Cell ... 85 80099 4 ref Subsequently a different, heterotrimeric plus end directed MT based motor named kinesin ... KP, Hall K, Vuong T, Scholey JM title Novel heterotrimeric kinesin related protein purified from ... cite journal author Yang JT, Laymon RA, Goldstein LS title A three domain structure of kinesin ... cite journal author Aizawa H, Sekine Y, Takemura R, Zhang Z, Nangaku M, Hirokawa N title Kinesin ... cite journal author Enos AP, Morris NR title Mutation of a gene that encodes a kinesin like protein ... Meluh PB, Rose MD title KAR3, a kinesin related gene required for yeast nuclear fusion journal Cell ... ref For example, the genomes of mammals encode more than 40 kinesin proteins, ref name pmid19773780 cite journal author Hirokawa N, Noda Y, Tanaka Y, Niwa S title Kinesin superfamily motor proteins and intracellular ... month October pmid 19773780 doi 10.1038 nrm2774 ref organized into at least 14 families named kinesin 1 through kinesin 14. ref name pmid15479732 cite journal author Lawrence CJ, Dawe RK, Christie KR ... CE, Wordeman L title A standardized kinesin nomenclature journal J. Cell Biol. volume 167 issue ... Overall structure Members of the kinesin superfamily vary in shape but the prototypical kinesin ... pair that binds two light chains KLCs . The heavy chain of kinesin 1 comprises a globular head ... dimerization of the two KHCs. In most cases transported cargo binds to the kinesin light chains ... H, Wagner MC, Brady ST, Bloom GS title Submolecular domains of bovine brain kinesin identified ... more details
The Kinesin 8 Family are a subfamily of the molecular motor proteins known as kinesin s. Most kinesins transport materials or cargo around the cell while traversing along microtubule polymer tracks with the help of ATP hydrolysis ATP hydrolysis created energy. The Kinesin 8 family has been shown to play an important role in chromosome alignment during mitosis . Kinesin 8 family members KIF18A in humans ref name Mayr cite journal author Mayr MI, H mmer S, Bormann J, et al. title The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression journal Curr Biol. volume 17 issue 6 pages 488 98 year 2007 month Mar pmid 17346968 doi 10.1016 j.cub.2007.02.036 ref and Kip3 in yeast ref name Gupta cite journal author Gupta ML, Carvalho P, Roof DM, Pellman D title Plus end specific depolymerase activity of Kip3, a kinesin 8 protein, explains its role in positioning the yeast mitotic spindle journal Nat Cell Biol. volume 8 issue 9 pages 913 23 year 2006 month Sep pmid 16906148 doi 10.1038 ncb1457 ref have been shown to be in vivo plus end directed microtubule depolymerizers. During prometaphase of mitosis , the microtubules attach to the kinetochores of sister chromatids . Kinesin 8 is thought to play some role in this process, as knockdown of this protein via siRNA produces a phenotype of sister chromatids that are unable to align properly see External Links . ref name Mayr ref name Stumpff cite journal author Stumpff J, von Dassow G, Wagenbach M, Asbury C, Wordeman L title The kinesin 8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment journal Dev Cell volume 14 issue 2 pages 252 62 year 2008 month Feb pmid 18267093 doi 10.1016 j.devcel.2007.11.014 pmc 2267861 ref References reflist External links http www.pubmedcentral.nih.gov picrender.fcgi?artid 2267861&blobname NIHMS40734 supplement 03.mov Video Illustrations of Kinesin 8 depletion Category Motor proteins ... more details
Refimprove date August 2010 The Kinesin 13 Family are a subfamily of motor proteins known as kinesin s. Most kinesins transport materials or cargo around the cell while traversing along microtubule polymer tracks with the help of ATP hydrolysis ATP hydrolysis created energy. Structure They are easily identified by their three typical structural components including a highly conserved structural domain, catalytic core, and microtubule binding sites. The kinesin 13 family, unlike other kinesins, has an internally positioned motor domain. They were initially named KIF M because of the unique location of their catalytic core in the middle of the polypeptide between the N terminal globular domain and the C terminal stalk but they are truly special due to their versatile nature. The Kinesin 13 family s molecular mechanism is less understood than other classes of kinesins which have their motor domains at one end of the molecule or the other. They are capable of traveling to both the minus and plus ends of microtubules whereas most motors are unidirectional. Thus they can catalytically polymerization depolymerize a microtubule from both ends making it a very efficient process. The exact mechanism of Kinesin 13 activated microtubule depolymerization remains unclear, however, recent biochemical and structural studies revealed some more detailed class specific features enabling researchers to formulate a model. ref cite journal last Ogawa first T coauthors Nitta, R., Okada, Y., and N. Hirokawa title A Common Mechanism for Microtubule Destabilizers M Type Kinesins Stabilize Curling of the Protofilament Using the Class Specific Neck and Loops journal Cell year 2004 volume 116 pages 591 602. pmid 14980225 ref . The protein first contacts the side wall of a microtubule. This is not a stable ... poles by a kinesin 13 dependent pacman flux mechanism in which one kinesin 13 isoform, KLP59c ... pacman , whereas a second kinesin 13 isoform, KLP10A, localized on the spindle poles facilitates ... more details
PBB geneid 3832 Kinesin family member 11 is a protein that in humans is encoded by the KIF11 gene . ref name entrez cite web title Entrez Gene Kinesin family member 11 url http www.ncbi.nlm.nih.gov sites entrez?db gene&cmd retrieve&list uids 3832 accessdate 2012 01 27T16 36 59.375 08 00 ref This gene encodes a motor protein that belongs to the kinesin like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. provided by RefSeq, Jul 2008 . ref name entrez cite web title Entrez Gene Kinesin family member 11 url http www.ncbi.nlm.nih.gov sites entrez?db gene&cmd retrieve&list uids 3832 accessdate 2012 01 27T16 36 59.375 08 00 ref References reflist Further reading refbegin 2 Cite pmid 11328809 Cite pmid 11416179 Cite pmid 14517947 Cite pmid 14527417 Cite pmid 14718566 Cite pmid 15024728 Cite pmid 1505978 Cite pmid 15247293 Cite pmid 15665380 Cite pmid 15858821 refend gene 10 stub ... more details
Catastrophin , or KIF2, is a Microtubule microtubal motor protein which causes destabilization, i.e. increases dynamic instability, of the microtubule plus end. It is specifically a kinesin like protein with a motor domain situated in the middle portion of its heavy chain. Contrary to probable belief, the catas prefix is related to the cata in catabolism while the troph is related to the troph in atrophy. The in is merely a the suffix many proteins share. See also Microtubule associated protein Kinesin Category Motor proteins biochem stub ... more details
Unreferenced auto yes date December 2009 about the WWII Polish political organization Home Political Representation the Finnish police agency Keskusrikospoliisi an airport in Denmark Karup Airport KRP stands for kinesin related proteins . bimC is a subfamily of KRPs and its function is to separate the duplicated centrosomes during mitosis . DEFAULTSORT Krp Category Proteins Biochem stub ... more details
A light chain is the small polypeptide subunit of a protein complex . More specifically, it can refer to Immunoglobulin light chain Ferritin light chain Myosin light chain Kinesin light chain Dynein light chain Light chain may also refer to Mail armour disambig ... more details
PBB geneid 3831 Kinesin light chain 1 is a protein that in humans is encoded by the KLC1 gene . ref name ... A, White B, Siciliano MJ, Lachman LB title Cloning and genetic characterization of the human kinesin ... AB, Kamal A, Ritchings BW, Philp AV, McGrail M, Gindhart JG, Goldstein LS title Kinesin dependent axonal ... web title Entrez Gene KNS2 kinesin 2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports ... activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N terminal domain, and six tetratricopeptide ..., and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named " kinesin 2" , this gene is not a member of the kinesin 2 kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces ... J G, Goldstein L S year 2000 month Nov. title Kinesin dependent axonal transport is mediated ... kinesin interacts with the SNARE proteins SNAP25 and SNAP23 journal Biochemistry volume 41 issue ... 1998 month Jun. title Two kinesin light chain genes in mice. Identification and characterization of the encoded ... kinesin heavy chain behavior in mouse kinesin light chain mutants journal J. Cell Biol. volume ... of the kinesin superfamily insights into structure and function journal Trends Cell Biol. volume ... Goedert M, Marsh S, Carter N title Localization of the human kinesin light chain gene KNS2 to chromosome ... J title Human kinesin light beta chain gene DNA sequence and functional characterization of its promoter ... 10.1089 dna.1996.15.965 cite journal author Khodjakov A title A specific light chain of kinesin associates ... LS title Two kinesin light chain genes in mice. Identification and characterization of the encoded ... doi 10.1074 jbc.273.25.15395 cite journal author Gyoeva FK, Bybikova EM, Minin AA title An isoform of kinesin ... more details
PBB geneid 3798 Kinesin heavy chain isoform 5A is a protein that in humans is encoded by the KIF5A gene . ref name pmid9858832 cite journal author Hamlin PJ, Jones PF, Leek JP, Bransfield K, Lench NJ, Aldersley MA, Howdle PD, Markham AF, Robinson PA title Assignment of GALGT encoding beta 1, 4N acetylgalactosaminyl transferase GalNAc T and KIF5A encoding neuronal kinesin D12S1889 to human chromosome band 12q13 by assignment to ICI YAC 26EG10 and in situ hybridization. medjph stjames.leeds.ac.uk journal ... cite web title Entrez Gene KIF5A kinesin family member 5A url http www.ncbi.nlm.nih.gov sites entrez ... summary text This gene encodes a member of the kinesin family of proteins. Members of this family ... cite web title Entrez Gene KIF5A kinesin family member 5A url http www.ncbi.nlm.nih.gov sites entrez .... title Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins ... coauthors Kamal A, Roberts E A, Goldstein L S year 1999 month Sep. title Defective kinesin heavy chain behavior in mouse kinesin light chain mutants journal J. Cell Biol. volume 146 issue 6 pages ... author Fichera M, Lo Giudice M, Falco M, et al. title Evidence of kinesin heavy chain KIF5A involvement ... and localization of a conventional kinesin motor expressed exclusively in neurons. journal Neuron ... gr.6.9.791 cite journal author Rahman A, Friedman DS, Goldstein LS title Two kinesin light chain ... author Rahman A, Kamal A, Roberts EA, Goldstein LS title Defective kinesin heavy chain behavior in mouse kinesin light chain mutants. journal J. Cell Biol. volume 146 issue 6 pages 1277 88 year 1999 ... Y, et al. title KIF5C, a novel neuronal kinesin enriched in motor neurons. journal J. Neurosci. volume ... Y, et al. title Glutamate receptor interacting protein GRIP1 directly steers kinesin to dendrites ... journal author Reid E, Kloos M, Ashley Koch A, et al. title A kinesin heavy chain KIF5A mutation in hereditary ... M, et al. title Beta dystrobrevin interacts directly with kinesin heavy chain in brain. journal ... more details
chembox Verifiedfields changed verifiedrevid 404920068 ImageFile1 Monastrol.2D.png ImageSize1 150px ImageFile2 Monastrol.3D.png ImageSize2 150px IUPACName ethyl 4 3 hydroxyphenyl 6 methyl 2 sulfanylidene 3,4 dihydro 1H pyrimidine 5 carboxylate OtherNames Monastrol Section1 Chembox Identifiers CASNo Ref cascite correct ?? CASNo PubChem 2987927 ChEMBL Ref ebicite changed EBI ChEMBL 236789 SMILES CCOC O C1 C NC S NC1C2 CC CC C2 O C InChI 1S C14H16N2O3S c1 3 19 13 18 11 8 2 15 14 20 16 12 11 9 5 4 6 10 17 7 9 h4 7,12,17H,3H2,1 2H3, H2,15,16,20 Section2 Chembox Properties Formula C sub 14 sub H sub 16 sub N sub 2 sub O sub 3 sub S MolarMass 292.35344 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Monastrol is a cell permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison . Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity. ref cite journal title Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype Based Screen author Thomas U. Mayer, Tarun M. Kapoor, Stephen J. Haggarty, Randall W. King, Stuart L. Schreiber, Timothy J. Mitchison journal Science year 1999 volume 286 issue 5441 pages 971 974 url http www.biochem.wisc.edu courses biochem704 Reading Mayer1999.pdf pmid 10542155 doi 10.1126 science.286.5441.971 ref Mechanism of action File Aurora inibitors.jpg thumb Monastrol inhibits Eg5 Monastrol binds to a long loop that is specific to the Eg5 kinesin family, and allosterically inhibits ATPase activity of the kinesin ref cite journal author Maliga Z, Kapoor TM, Mitchison TJ title Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5 journal Chem. Biol. volume 9 issue 9 pages 989 96 year 2002 month September pmid 12323373 doi 10.1016 S1074 5521 02 00212 0 url ref References reflist 2 Category Pharmacology pharma stub ... more details
in cells becomes evident when they fail to fulfill their function. For example, kinesin deficiencies ... such as dynein and kinesin move along microtubule s through interaction with tubulin . There are two ... 13 Mammal s human 40 Microtubule motors KinesinKinesin s are a group of related motor proteins ... end or the minus end, depending on the type of kinesin. Fourteen distinct kinesin families are known, with some additional kinesin like proteins that cannot be classified into these families. ref name Miki cite journal author Miki H, Okada Y, Hirokawa N title Analysis of the kinesin superfamily insights ... pmid 16084724 doi 10.1016 j.tcb.2005.07.006 issue 9 ref Genomic representation of kinesin motors ref ... are much larger and more complex than kinesin and myosin motors. Dynein facilitates the movement ... specific kinesin groups are specialized for functions during plant cell mitosis . ref name ... cell mitosis. The building of cell plate and ultimately the new cell wall requires kinesin like motor ... 9822 02 00751 0 ref Another motor protein essential for plant cell division is kinesin like calmodulin binding protein KCBP , which is unique to plants and part kinesin and part myosin. ref name ... of kinesin like calmodulin binding protein journal Plant Physiology date 2005 volume 138 pages 1711 ... more details
PBB geneid 9371 Kinesin like protein KIF3B is a protein that in humans is encoded by the KIF3B gene . ref name pmid9205841 cite journal author Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O title Prediction of the coding sequences of unidentified ... doi 10.1093 dnares 4.2.141 ref ref name entrez cite web title Entrez Gene KIF3B kinesin family member ... ref Function The protein encoded by this gene forms a heterotrimeric motor complex with KIF3A kinesin family member 3A and KAP3 kinesin accessory protein 3 to drive intra flagellum flagellar transport ... of membranous organelle s. The heterotrimeric KIF3B KIF3A KAP3 motor protein is a member of the kinesin 2 subfamily of the kinesin superfamily. ref name entrez ref name pmid8601599 cite journal author Scholey JM title Kinesin II, a membrane traffic motor in axons, axonemes, and spindles journal J. Cell ... kinesin nomenclature journal Journal of Cell Biology year 2004 volume 167 pages 19 22 pmid 15479732 ... lambda mediated functional coupling between Rab4 and the motor protein kinesin journal Mol. Cell. Biol ... H, Nakata T, Okada Y, Hirokawa N title KIF3A B a heterodimeric kinesin superfamily protein that works ... with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. journal ... phenotyping of HT 29 cells cloning of ser thr protein kinase EMK1, kinesin KIF3B, and of transcripts ... microtubule motor kinesin II in vertebrate retina. journal Exp. Eye Res. volume 69 issue ... suppressor APC and the kinesin superfamily. journal Nat. Cell Biol. volume 4 issue 4 pages 323 ... K, et al. title IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved ... coupling between Rab4 and the motor protein kinesin. journal Mol. Cell. Biol. volume 23 issue 14 ... author Haraguchi K, Hayashi T, Jimbo T, et al. title Role of the kinesin 2 family protein, KIF3, during ... jbc.M507028200 cite journal author Wu Y, Dai XQ, Li Q, et al. title Kinesin 2 mediates physical ... more details
PBB geneid 147700 Kinesin light chain 3 is a protein that in humans is encoded by the KLC3 gene . ref name entrez cite web title Entrez Gene KLC3 kinesin light chain 3 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 147700 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain KHC and two kinesin light chain KLC molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post meiotic spermatids, where it associates with structural components of sperm tails and mitochondria. ref name entrez Interactions KLC3 has been shown to Protein protein interaction interact with YWHAH . ref name pmid11969417 cite journal last Ichimura first Tohru authorlink coauthors Wakamiya Tsuruta Akiko, Itagaki Chiharu, Taoka Masato, Hayano Toshiya, Natsume Tohru, Isobe Toshiaki year 2002 month Apr. title Phosphorylation dependent interaction of kinesin light ..., van der Hoorn FA title Rat kinesin light chain 3 associates with spermatid mitochondria journal Dev ... of kinesin light chain with outer dense fibers in a microtubule independent fashion journal ... Tsuruta A, Itagaki C, et al. title Phosphorylation dependent interaction of kinesin light chain ... Kinesin light chain KLC3 expression in testis is restricted to spermatids journal Biol. Reprod. volume ... author Rahman A, Kamal A, Roberts EA, Goldstein LS title Defective kinesin heavy chain behavior in mouse kinesin light chain mutants journal J. Cell Biol. volume 146 issue 6 pages 1277 88 year 1999 pmid ... LS title Two kinesin light chain genes in mice. Identification and characterization of the encoded ... more details
PBB geneid 3800 Kinesin heavy chain isoform 5C is a protein that in humans is encoded by the KIF5C gene . ref name pmid7514426 cite journal author Niclas J, Navone F, Hom Booher N, Vale RD title Cloning and localization of a conventional kinesin motor expressed exclusively in neurons journal Neuron volume 12 issue 5 pages 1059 72 year 1994 month Jun pmid 7514426 pmc doi 10.1016 0896 6273 94 90314 X ref ref name entrez cite web title Entrez Gene KIF5C kinesin family member 5C url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3800 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Engelender S, Sharp AH, Colomer V, et al. title Huntingtin associated protein 1 HAP1 interacts with the p150Glued subunit of dynactin. journal Hum. Mol. Genet. volume 6 issue 13 pages 2205 12 year 1998 pmid 9361024 doi 10.1093 hmg 6.13.2205 cite journal author Nagase T, Ishikawa K, Miyajima N, et al. title Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. journal DNA Res. volume 5 issue 1 pages 31 9 year 1998 pmid 9628581 doi 10.1093 dnares 5.1.31 cite journal author Xia Ch, Rahman A, Yang Z, Goldstein LS title Chromosomal localization reveals three kinesin heavy chain genes in mouse. journal Genomics volume 52 issue 2 pages 209 13 year 1998 pmid 9782088 doi 10.1006 geno.1998.5427 cite journal author Junco A, Bhullar B, Tarnasky HA, van der Hoorn FA title Kinesin light chain KLC3 expression in testis is restricted to spermatids. journal ... of a novel gene family of coiled coil domain proteins association in vivo and in vitro with kinesin ... 1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF 1 as an adaptor protein in the anterograde ... more details
PBB geneid 3797 Kinesin like protein KIF3C is a protein that in humans is encoded by the KIF3C gene . ref name pmid9480755 cite journal author Sardella M, Navone F, Rocchi M, Rubartelli A, Viggiano L, Vignali G, Consalez GG, Sitia R, Cabibbo A title KIF3C, a novel member of the kinesin superfamily sequence, expression, and mapping to human chromosome 2 at 2p23 journal Genomics volume 47 issue 3 pages 405 8 year 1998 month Apr pmid 9480755 pmc doi 10.1006 geno.1997.5123 ref ref name entrez cite web title Entrez Gene KIF3C kinesin family member 3C url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3797 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Davidovic L, Jaglin XH, Lepagnol Bestel AM, et al. title The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules. journal Hum. Mol. Genet. volume 16 issue 24 pages 3047 58 year 2008 pmid 17881655 doi 10.1093 hmg ddm263 cite journal author Kimura K, Wakamatsu A, Suzuki Y, et al. title Diversification of transcriptional modulation large scale identification and characterization of putative alternative promoters of human genes. journal Genome Res. volume 16 issue 1 pages 55 65 year 2006 pmid 16344560 doi 10.1101 gr.4039406 pmc 1356129 cite journal author Gerhard DS, Wagner L, Feingold EA, et al. title The status, quality, and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC . journal ... and KIF3A form a novel neuronal heteromeric kinesin that associates with membrane vesicles. journal ... Yang Z, Goldstein LS title Characterization of the KIF3C neural kinesin like motor from mouse ... localization of a novel human gene that encodes a kinesin related protein highly similar to mouse ... more details
PBB geneid 3799 Kinesin 1 heavy chain is a protein that in humans is encoded by the KIF5B gene . ref ... G, Vale RD title Cloning and expression of a human kinesin heavy chain gene interaction of the COOH ... ref ref name entrez cite web title Entrez Gene KIF5B kinesin family member 5B url http www.ncbi.nlm.nih.gov ... chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23 journal Biochemistry ... A authorlink coauthors Friedman D S, Goldstein L S year 1998 month Jun. title Two kinesin light chain ... E A, Goldstein L S year 1999 month Sep. title Defective kinesin heavy chain behavior in mouse kinesin light chain mutants journal J. Cell Biol. volume 146 issue 6 pages 1277 88 publisher location ... dependent interaction of kinesin light chain 2 and the 14 3 3 protein journal Biochemistry volume ... N, Vale RD title Cloning and localization of a conventional kinesin motor expressed exclusively in neurons ... 94 90314 X cite journal author Kull FJ, Sablin EP, Lau R, et al. title Crystal structure of the kinesin ... DS, Goldstein LS title Two kinesin light chain genes in mice. Identification and characterization ... disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear ... Defective kinesin heavy chain behavior in mouse kinesin light chain mutants. journal J. Cell Biol. volume ... journal author Ong LL, Lim AP, Er CP, et al. title Kinectin kinesin binding domains and their effects ..., a novel neuronal kinesin enriched in motor neurons. journal J. Neurosci. volume 20 issue 17 pages ... receptor interacting protein GRIP1 directly steers kinesin to dendrites. journal Nature volume ... MA, Speicher DW, Shiekhattar R title The motor protein kinesin 1 links neurofibromin and merlin in a common ... E, Douglas MW, Cunningham AL title The heavy chain of conventional kinesin interacts with the SNARE ... Beta dystrobrevin interacts directly with kinesin heavy chain in brain. journal J. Cell. Sci. volume ... receptor, p180, interacts with kinesin heavy chain, KIF5B. journal Biochem. Biophys. Res ... more details
PBB geneid 11004 Kinesin like protein KIF2C is a protein that in humans is encoded by the KIF2C gene . ref name pmid9434124 cite journal author Kim IG, Jun DY, Sohn U, Kim YH title Cloning and expression of human mitotic centromere associated kinesin gene journal Biochim Biophys Acta volume 1359 issue 3 pages 181 6 year 1998 month Feb pmid 9434124 pmc doi ref ref name entrez cite web title Entrez Gene KIF2C kinesin family member 2C url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 11004 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The protein encoded by this gene is a member of kinesin like protein family. Most proteins of this family are microtubule dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein acts to regulate microtubule dynamics in cells and is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation. ref name entrez References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Miki H, Setou M, Kaneshiro K, Hirokawa N title All kinesin superfamily protein, KIF, genes in mouse and human journal Proc. Natl. Acad. Sci. U.S.A. volume 98 issue 13 pages ... AW, Wagenbach M, Wordeman L title Mitotic Centromere associated Kinesin Is Important for Anaphase ... kinesin MCAK journal Cell Biol. Int. volume 23 issue 4 pages 275 86 year 2000 pmid 10600236 doi ... activity of mitotic centromere associated kinesin journal J. Biol. Chem. volume 276 issue 37 ... 07 0544 pmc 379257 cite journal author Ganem NJ, Compton DA title The KinI kinesin Kif2a is required ... author Newton CN, Wagenbach M, Ovechkina Y, et al. title MCAK, a Kin I kinesin, increases the catastrophe ... author Helenius J, Brouhard G, Kalaidzidis Y, et al. title The depolymerizing kinesin MCAK uses lattice ... more details
PBB geneid 57576 Kinesin like protein KIF17 is a protein that in humans is encoded by the KIF17 gene . ref name pmid10846156 ref name entrez cite web title Entrez Gene KIF17 kinesin family member 17 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 57576 accessdate ref KIF17 and its close relative, Caenorhabditis elegans C. elegans OSM 3, ref name pmid7690265 are members of the kinesin 2 family of plus end directed microtubule based motor protein s. ref name pmid15479732 In contrast to heterotrimeric kinesin 2 motors, ref name pmid8232586 however, KIF17 and OSM 3 form distinct protein dimer homodimeric complexes. ref name pmid9950681 Homodimeric kinesin 2 has been implicated in the transport of NMDA receptor s along dendrite s for delivery to the dendritic membrane, ref name pmid10846156 whereas both protein trimer heterotrimeric and homodimeric kinesin 2 motors function cooperatively in anterograde intraflagellar transport IFT and cilium biogenesis . ref name pmid15489852 ref name pmid20526328 References reflist colwidth 35em refs ref name pmid10846156 cite journal author Setou M, Nakagawa T, Seog DH, Hirokawa N title Kinesin superfamily motor protein ... name entrez cite web title Entrez Gene KIF17 kinesin family member 17 url http www.ncbi.nlm.nih.gov ... osmotic avoidance behaviour encodes a kinesin like protein journal Neuroreport volume 4 issue ... M, Scholey JM, Vale RD, Walczak CE, Wordeman L title A standardized kinesin nomenclature journal ... K, Vuong T, Scholey JM title Novel heterotrimeric kinesin related protein purified from sea urchin ... title Two heteromeric kinesin complexes in chemosensory neurons and sensory cilia of Caenorhabditis ... JR, Verhey KJ title Ciliary entry of the kinesin 2 motor KIF17 is regulated by importin beta2 and RanGTP ... N, Sassone Corsi P title CREM dependent transcription in male germ cells controlled by a kinesin journal ... M, Hecht NB title The kinesin KIF17b and RNA binding protein TB RBP transport specific cAMP responsive ... more details
PBB geneid 547 Kinesin like protein KIF1A , also known as axonal transporter of synaptic vesicles or microtubule based motor KIF1A , is a protein that in humans is encoded by the KIF1A gene . ref name entrez cite web title Entrez Gene kinesin family member 1A url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 547 accessdate ref ref name pmid7539720 cite journal author Okada Y, Yamazaki H, Sekine Aizawa Y, Hirokawa N title The neuron specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors journal Cell volume 81 issue 5 pages 769 80 year 1995 month June pmid 7539720 doi 10.1016 0092 8674 95 90538 3 ref ref name pmid10323250 cite journal author Keller MP, Seifried BA, Rabin BA, Chance PF title Mapping of the kinesin related gene ATSV to chromosome 2q37 journal Hum. Genet. volume 104 issue 3 pages 254 6 year 1999 month March pmid 10323250 doi 10.1007 s004390050944 ref Function KIF1A is a member of the kinesin family. This protein is highly similar to mouse heavy chain kinesin member 1A protein which is an anterograde motor protein that transports membranous organelles along axon al microtubule s. It is thought that this protein may play a critical role in the development of axonal neuropathy neuropathies resulting from impaired axonal transport. There are multiple polyadenylation sites found in this gene. ref name entrez Clinical significance KIF1A is associated with hereditary ... of a kinesin related gene ATSV, within the tuberous sclerosis locus TSC1 candidate region ... virus type 2 membrane protein UL56 associates with the kinesin motor protein KIF1A. journal J. Gen ... of the kinesin motor KIF1A with the multimodular protein liprin alpha. journal J. Biol. Chem. volume ... coil negatively regulates the kinesin motor KIF1A. journal EMBO J. volume 23 issue 7 pages ... Characterization of the movement of the kinesin motor KIF1A in living cultured neurons. journal ... more details
PBB geneid 10112 Kinesin like protein KIF20A is a protein that in humans is encoded by the KIF20A gene . ref name pmid11416179 cite journal author Miki H, Setou M, Kaneshiro K, Hirokawa N title All kinesin superfamily protein, KIF, genes in mouse and human journal Proc Natl Acad Sci U S A volume 98 issue 13 pages 7004 11 year 2001 month Jun pmid 11416179 pmc 34614 doi 10.1073 pnas.111145398 ref ref name pmid10806357 cite journal author Lai F, Fernald AA, Zhao N, Le Beau MM title cDNA cloning, expression pattern, genomic structure and chromosomal location of RAB6KIFL, a human kinesin like gene journal Gene volume 248 issue 1 2 pages 117 25 year 2000 month Jul pmid 10806357 pmc doi 10.1016 S0378 1119 00 00135 9 ref ref name entrez cite web title Entrez Gene KIF20A kinesin family member 20A url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 10112 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions KIF20A has been shown to Protein protein interaction interact with RAB6A . ref name pmid9438855 cite journal last Echard first A authorlink coauthors Jollivet F, Martinez O, Lacap re J J, Rousselet A, Janoueix Lerosey I, Goud B year 1998 month Jan. title Interaction of a Golgi associated kinesin like protein with Rab6 journal Science journal Science volume 279 issue 5350 pages 580 5 publisher location UNITED STATES issn 0036 8075 ... of a Golgi associated kinesin like protein with Rab6 journal Science volume 279 issue 5350 pages ... author Hill E, Clarke M, Barr FA title The Rab6 binding kinesin, Rab6 KIFL, is required for cytokinesis ... 310948 cite journal author Nagura M, Nagao Y, Takita J, et al. title The kinesin superfamily protein ..., Preisinger C, Sutcliffe J, et al. title Phosphorylation of mitotic kinesin like protein 2 by polo ... H, Nakamura T, et al. title Down regulation of RAB6KIFL KIF20A, a kinesin involved with membrane ... more details
PBB geneid 55614 Kinesin family member 16B , also known as KIF16B , is a protein which in humans is encoded by the KIF16B gene . ref name entrez cite web title Entrez Gene KIF16B kinesin family member 16B url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 55614 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text See also Kinesin References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Seet LF, Hong W title The Phox PX domain proteins and membrane traffic. journal Biochim. Biophys. Acta volume 1761 issue 8 pages 878 96 year 2006 pmid 16782399 doi 10.1016 j.bbalip.2006.04.011 cite journal author Miki H, Okada Y, Hirokawa N title Analysis of the kinesin superfamily insights into structure and function. journal Trends Cell Biol. volume 15 issue 9 pages 467 76 year 2005 pmid 16084724 doi 10.1016 j.tcb.2005.07.006 cite journal author Worby CA, Dixon JE title Sorting out the cellular functions of sorting nexins. journal Nat. Rev. Mol. Cell Biol. volume 3 issue 12 pages 919 31 year 2003 pmid 12461558 doi 10.1038 nrm974 cite journal author Vasilescu J, Zweitzig DR, Denis NJ, et al. title The proteomic reactor facilitates the analysis of affinity purified proteins by mass spectrometry application for identifying ubiquitinated proteins in human cells. journal J. Proteome Res. volume 6 issue 1 pages 298 305 year 2007 pmid 17203973 doi 10.1021 pr060438j cite journal author Hoepfner S, Severin F, Cabezas A, et al. title Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B. journal Cell volume 121 issue 3 pages 437 50 year 2005 pmid 15882625 doi 10.1016 j.cell.2005.02.017 cite journal author Gerhard DS, Wagner L, Feingold EA, et al. title The status, quality, and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC . journal Genome Res. volume ... more details
PBB geneid 3833 Kinesin like protein KIFC1 is a protein that in humans is encoded by the KIFC1 gene . ref name pmid8276466 cite journal author Ando A title Cloning of a new kinesin related gene located at the centromeric end of the human MHC region journal Immunogenetics volume 39 issue 3 pages 194 200 year 1994 month Feb pmid 8276466 pmc doi author separator , author2 Kikuti YY author3 Kawata H author4 Okamoto N author5 Imai T author6 Eki T author7 Yokoyama K author8 Soeda E author9 Ikemura T display authors 10 ref ref name entrez cite web title Entrez Gene KIFC1 kinesin family member C1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3833 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Miki H, Setou M, Kaneshiro K, Hirokawa N title All kinesin superfamily protein, KIF, genes in mouse and human journal Proc. Natl. Acad. Sci. U.S.A. volume 98 issue 13 pages 7004 11 year 2001 pmid 11416179 doi 10.1073 pnas.111145398 pmc 34614 cite journal author Janitz K title Genomic organization of the HSET locus and the possible association of HLA linked genes with immotile cilia syndrome ICS journal Immunogenetics volume 49 issue 7 8 pages 644 52 year 1999 pmid 10369922 doi 10.1007 s002510050660 author separator , author2 Wild A author3 Beck S display authors 3 last4 Savasta first4 S. last5 Beluffi first5 Giampiero last6 Ziegler first6 A. last7 Volz first7 Armin cite journal author Strausberg RL title Generation and initial analysis of more than 15,000 full length human and mouse cDNA sequences journal Proc. Natl. Acad. Sci. U.S.A. volume ... GD cite journal author Neef R title Phosphorylation of mitotic kinesin like protein 2 by polo ... J, Roger B, Halpain S, Milligan RA title Analysis of the weak interactions of ADP Unc104 and ADP kinesin ... more details
PBB geneid 3796 Kinesin like protein KIF2A is a protein that in humans is encoded by the KIF2A gene . ref name pmid9177777 cite journal author Debernardi S, Fontanella E, De Gregorio L, Pierotti MA, Delia D title Identification of a novel human kinesin related gene HK2 by the cDNA differential display technique journal Genomics volume 42 issue 1 pages 67 73 year 1997 month Jul pmid 9177777 pmc doi 10.1006 geno.1997.4720 ref ref name entrez cite web title Entrez Gene KIF2A kinesin heavy chain member 2A url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3796 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Kinesins, such as KIF2, are microtubule associated motor proteins. For background information on kinesins, see MIM 148760. supplied by OMIM ref name entrez cite web title Entrez Gene KIF2A kinesin heavy chain member 2A url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3796 accessdate ref References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Manning AL, Ganem NJ, Bakhoum SF, et al. title The kinesin 13 proteins Kif2a, Kif2b, and Kif2c MCAK have distinct roles during mitosis in human cells. journal Mol. Biol. Cell volume 18 issue 8 pages 2970 9 year 2007 pmid 17538014 doi 10.1091 mbc.E07 02 0110 pmc 1949365 cite journal author Schepis A, Stauber T, Krijnse Locker J title Kinesin 1 plays multiple roles during the vaccinia virus life cycle. journal Cell. Microbiol. volume 9 issue 8 pages 1960 73 year 2008 pmid 17394562 doi 10.1111 j.1462 5822.2007.00927.x cite journal author Li C, Zheng Y, Qin W, et al. title A family based association study of kinesin heavy chain member 2 gene KIF2 and schizophrenia. journal Neurosci. Lett. volume 407 issue 2 pages ... doi 10.1101 gr.2596504 pmc 528928 cite journal author Ganem NJ, Compton DA title The KinI kinesin ... more details
PBB geneid 11127 Kinesin like protein KIF3A is a protein that in humans is encoded by the KIF3A gene . ref name pmid10548469 cite journal author Whitehead JL, Wang SY, Bost Usinger L, Hoang E, Frazer KA, Burnside B title Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina journal Exp. Eye Res. volume 69 issue 5 pages 491 503 year 1999 month November pmid 10548469 doi 10.1006 exer.1999.0724 ref ref name entrez cite web title Entrez Gene KIF3A kinesin family member 3A url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ... heterotrimeric motor protein, kinesin 2, that was initially isolated from sea urchin egg embryo ... SW, Wedaman KP, Hall K, Vuong T, Scholey JM title Novel heterotrimeric kinesin related protein ... pmid 8232586 doi 10.1038 366268a0 ref This motor consists of two kinesin related subunits called .... Work done in a broad range of eukaryotic cells has revealed that heterotrimeric kinesin 2 is the primary ..., in vertebrate embryos, kinesin 2 function is required for cilia dependent nodal flow and the development ... JNK along microtubules and associates with kinesin superfamily motor KIF3 journal EMBO ... R, et al. title Kinesin family in murine central nervous system. journal J. Cell Biol. volume ... author Yamazaki H, Nakata T, Okada Y, Hirokawa N title KIF3A B a heterodimeric kinesin superfamily ... with kinesin superfamily motor KIF3. journal EMBO J. volume 17 issue 1 pages 149 58 year 1998 pmid ... of the KIF3C neural kinesin like motor from mouse. journal Mol. Biol. Cell volume 9 issue ... title Interaction between GADD34 and kinesin superfamily, KIF3A. journal Biochem. Biophys. Res. Commun ... APC and the kinesin superfamily. journal Nat. Cell Biol. volume 4 issue 4 pages 323 7 year 2002 ..., Maier KC, Stauber T, et al. title Kinesin 2 is a motor for late endosomes and lysosomes. journal ... cite journal author Haraguchi K, Hayashi T, Jimbo T, et al. title Role of the kinesin 2 family protein ... more details
PBB geneid 64837 Kinesin light chain 2 is a protein that in humans is encoded by the KLC2 gene . ref name pmid9624122 cite journal author Rahman A, Friedman DS, Goldstein LS title Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins journal J Biol Chem volume 273 issue 25 pages 15395 403 year 1998 month Jul pmid 9624122 pmc doi 10.1074 jbc.273.25.15395 ref ref name entrez cite web title Entrez Gene KLC2 kinesin light chain 2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 64837 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions KLC2 has been shown to Protein protein interaction interact with MAPK8IP3 ref name pmid11106729 cite journal last Bowman first A B authorlink coauthors Kamal A, Ritchings B W, Philp A V, McGrail M, Gindhart J G, Goldstein L S year 2000 month Nov. title Kinesin dependent axonal transport is mediated by the sunday driver SYD protein journal Cell volume 103 issue 4 pages 583 94 publisher location UNITED STATES issn 0092 8674 pmid 11106729 bibcode oclc id url language format accessdate laysummary laysource laydate quote doi 10.1016 S0092 8674 00 00162 8 unused data DUPLICATE DATA pmid 11106727 ref and KIF5B . ref name pmid9624122 cite journal last Rahman first A authorlink coauthors Friedman D S, Goldstein L S year 1998 month Jun. title Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins journal J. Biol. Chem. volume 273 issue 25 pages 15395 403 publisher location UNITED STATES issn 0021 9258 pmid ... A, Roberts E A, Goldstein L S year 1999 month Sep. title Defective Kinesin Heavy Chain Behavior in Mouse Kinesin Light Chain Mutants journal J. Cell Biol. volume 146 issue 6 pages 1277 88 publisher ... Bowman AB, Kamal A, Ritchings BW, et al. title Kinesin dependent axonal transport is mediated by the sunday ... more details
Encyclopedia
top
