Transport by molecular motor proteins Kinesin , Dynein and unconventional Myosin is essential for cell functioning and survival. Studies of multiple motors are inspired by the fact that multiple motors are involved in many biological processes such as intra cellular transport and mitosis. This increasing interest in modeling multiple motor transport is particularly due to improved understanding of single motor function. Several models have been proposed in recent year to understand the transport by multiple motors. ref cite journal author Hancock WO title Intracellular transport kinesins working together journal Current Biology volume 18 issue 16 pages R715 7 year 2008 month August pmid 18727910 doi 10.1016 j.cub.2008.07.068 ref ref cite journal author Kunwar A, Vershinin M, Xu J, Gross SP title Stepping, strain gating, and an unexpected force velocity curve for multiple motor based transport journal Current Biology volume 18 issue 16 pages 1173 83 year 2008 month August pmid 18701289 doi 10.1016 j.cub.2008.07.027 ref ref cite journal author Klumpp S, Lipowsky R title Cooperative cargo transport by several molecular motors journal Proceedings of the National Academy of Sciences of the United States of America volume 102 issue 48 pages 17284 9 year 2005 month November pmid 16287974 pmc 1283533 doi 10.1073 pnas.0507363102 ref Models developed can be broadly divided into two categories 1 mean field steady state model and 2 stochastic model. The mean field model is useful for describing transport by a large group of motors. In mean field description, fluctuation in the forces that individual motors feel while pulling the cargo is ignored. In stochastic model, fluctuation in the forces that motors feel are not ignored. Steady state mean field model is useful for modeling transport by a large group of motors whereas stochastic model is useful for modeling transport by few motors. gallery Image Multiple Kinesin Models.jpg Models of multiple motor based transport. Steady state ... more details
PBB geneid 3801 Kinesin like protein KIFC3 is a protein that in humans is encoded by the KIFC3 gene . ref name pmid9782090 cite journal author Hoang EH, Whitehead JL, Dose AC, Burnside B title Cloning of a novel C terminal kinesin KIFC3 that maps to human chromosome 16q13 q21 and thus is a candidate gene for Bardet Biedl syndrome journal Genomics volume 52 issue 2 pages 219 22 year 1998 month Dec pmid 9782090 pmc doi 10.1006 geno.1998.5431 ref ref name entrez cite web title Entrez Gene KIFC3 kinesin family member C3 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3801 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Diu A, Moebius U, Ferradini L, et al. title Limited T cell receptor diversity in liver infiltrating lymphocytes from patients with primary biliary cirrhosis. journal J. Autoimmun. volume 6 issue 5 pages 611 9 year 1993 pmid 8240664 doi 10.1006 jaut.1993.1050 cite journal author Hoang E, Bost Usinger L, Burnside B title Characterization of a novel C kinesin KIFC3 abundantly expressed in vertebrate retina and RPE. journal Exp. Eye Res. volume 69 issue 1 pages 57 68 year 1999 pmid 10375449 doi 10.1006 exer.1999.0671 cite journal author Noda Y, Okada Y, Saito N, et al. title KIFC3, a microtubule minus end directed motor for the apical transport of annexin XIIIb associated Triton insoluble membranes. journal J. Cell Biol. volume 155 issue 1 pages 77 88 year 2001 pmid 11581287 doi 10.1083 jcb.200108042 pmc 2150803 cite journal author Xu Y, Takeda S, Nakata T, et al. title Role of KIFC3 motor protein in Golgi positioning and integration. journal J. Cell Biol. volume 158 issue 2 pages 293 303 year 2002 pmid 12135985 doi 10.1083 jcb.200202058 pmc 2173137 cite journal author Strausberg RL, Feingold EA, Grouse LH, et al ... more details
PBB geneid 9493 Kinesin like protein KIF23 is a protein that in humans is encoded by the KIF23 gene . ref name pmid1406973 cite journal author Nislow C, Lombillo VA, Kuriyama R, McIntosh JR title A plus end directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles journal Nature volume 359 issue 6395 pages 543 7 year 1992 month Nov pmid 1406973 pmc doi 10.1038 359543a0 ref ref name entrez cite web title Entrez Gene KIF23 kinesin family member 23 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 9493 accessdate ref Function The protein encoded by this gene is a member of kinesin like protein family. This family includes microtubule dependent molecular motors that transport organelle s within cells and move chromosomes during cell division . This protein has been shown to cross bridge antiparallel microtubule s and drive microtubule movement in vitro. Alternate splicing of this gene results in two transcript variants encoding two different protein isoform isoform s. ref name entrez cite web title Entrez Gene KIF23 kinesin family member 23 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... RA title Arf proteins bind to mitotic kinesin like protein 1 MKLP1 in a GTP dependent fashion journal ... N title All kinesin superfamily protein, KIF, genes in mouse and human. journal Proc. Natl ... protein kinase and interacts with a kinesin like protein, CHO1 MKLP 1. journal Mol. Cell. Biol ... BE, Walker RA title Nuclear localization of C terminal domains of the kinesin like protein MKLP 1 ... kinesin like protein 1 MKLP1 in a GTP dependent fashion. journal Cell Motil. Cytoskeleton volume ... require a kinesin like protein RhoGAP complex with microtubule bundling activity. journal ... cite journal author Kuriyama R, Gustus C, Terada Y, et al. title CHO1, a mammalian kinesin like protein ... T, Kuriyama R, Erikson RL title Molecular interactions of Polo like kinase 1 with the mitotic kinesin ... more details
PBB geneid 10749 Kinesin like protein KIF1C is a protein that in humans is encoded by the KIF1C gene . ref name pmid9685376 cite journal author Dorner C, Ciossek T, Muller S, Moller PH, Ullrich A, Lammers R title Characterization of KIF1C, a new kinesin like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum journal J Biol Chem volume 273 issue 32 pages 20267 75 year 1998 month Sep pmid 9685376 pmc doi 10.1074 jbc.273.32.20267 ref ref name entrez cite web title Entrez Gene KIF1C kinesin family member 1C url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 10749 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions KIF1C has been shown to Protein protein interaction interact with PTPN21 ref name pmid9685376 cite journal last Dorner first C authorlink coauthors Ciossek T, M ller S, M ller P H, Ullrich A, Lammers R year 1998 month Aug. title Characterization of KIF1C, a new kinesin like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum journal J. Biol. Chem. volume 273 issue 32 pages 20267 75 publisher location UNITED STATES issn 0021 9258 pmid 9685376 bibcode oclc id url language format accessdate laysummary laysource laydate quote doi 10.1074 jbc.273.32.20267 ref and YWHAG . ref name pmid10559254 cite journal last Dorner first C authorlink coauthors Ullrich A, H ring H U, Lammers R year 1999 month Nov. title The kinesin like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14 3 3 family journal J. Biol. Chem. volume 274 issue 47 pages 33654 60 publisher location UNITED STATES issn 0021 9258 pmid ... Dorner C, Ullrich A, H ring HU, Lammers R title The kinesin like motor protein KIF1C occurs in intact ... author Kopp P title The Kinesin KIF1C and Microtubule Plus Ends Regulate Podosome Dynamics in Macrophages ... more details
, an anchoring protein of kinesin motor journal Biochem. Biophys. Res. Commun. volume 225 issue 1 pages ..., Kumar J, et al. title Characterization of kinectin, a kinesin binding protein primary sequence and N ... of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor journal Biochem ... A, et al. title Kinesin and kinectin can associate with the melanosomal surface and form a link with microtubules ... doi cite journal author Ong LL, Lim AP, Er CP, et al. title Kinectin kinesin binding domains and their effects ... more details
PBB geneid 24137 Chromosome associated kinesin KIF4A is a protein that in humans is encoded by the KIF4A gene . ref name pmid10773663 cite journal author Ha MJ, Yoon J, Moon E, Lee YM, Kim HJ, Kim W title Assignment of the kinesin family member 4 genes KIF4A and KIF4B to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization journal Cytogenet Cell Genet volume 88 issue 1 2 pages 41 2 year 2000 month Jun pmid 10773663 pmc doi 10.1159 000015482 ref ref name entrez cite web title Entrez Gene KIF4A kinesin family member 4A url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 24137 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Kinesins, such as KIF4A, are microtubule based motor proteins that generate directional movement along microtubules. They are involved in many crucial cellular processes, including cell division Zhu and Jiang, 2005 . supplied by OMIM ref name entrez cite web title Entrez Gene KIF4A kinesin family member 4A url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 24137 accessdate ref Interactions KIF4A has been shown to Protein protein interaction interact with HMG20B ref name pmid12809554 cite journal last Lee first Young Mi authorlink coauthors Kim Wankee year 2003 month Sep. title Association of human kinesin superfamily protein member 4 with BRCA2 associated factor 35 journal Biochem. J. volume 374 issue Pt 2 pages 497 503 publisher location England issn pmid 12809554 ... H, Torrey TA, et al. title Identification of the human homologue of mouse KIF4, a kinesin superfamily ... doi cite journal author Lee YM, Lee S, Lee E, et al. title Human kinesin superfamily member 4 ... pmc 139241 cite journal author Lee YM, Kim W title Association of human kinesin superfamily ... Kinesin superfamily protein member 4 KIF4 is localized to midzone and midbody in dividing cells ... more details
PBB geneid 81930 Kinesin like protein KIF18A is a protein that in humans is encoded by the KIF18A gene . ref name pmid11230166 cite journal author Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A title Toward a catalog of human genes and proteins sequencing and analysis of 500 novel complete protein coding human cDNAs journal Genome Res volume 11 issue 3 pages 422 35 year 2001 month Mar pmid 11230166 pmc 311072 doi 10.1101 gr.GR1547R ref ref name entrez cite web title Entrez Gene KIF18A kinesin family member 18A url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 81930 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Hartley JL, Temple GF, Brasch MA title DNA cloning using in vitro site specific recombination. journal Genome Res. volume 10 issue 11 pages 1788 95 year 2001 pmid 11076863 doi 10.1101 gr.143000 pmc 310948 cite journal author Strausberg RL, Feingold EA, Grouse LH, et al. title Generation and initial analysis of more than 15,000 full length human and mouse cDNA sequences. journal Proc. Natl. Acad. Sci. U.S.A. volume 99 issue 26 pages 16899 903 year 2003 pmid 12477932 doi 10.1073 pnas.242603899 pmc 139241 cite journal author Ota T, Suzuki Y, Nishikawa T, et al. title Complete sequencing and characterization of 21,243 full length human cDNAs. journal Nat. Genet. volume 36 issue 1 pages 40 5 year 2004 pmid 14702039 ... doi 10.1101 gr.2576704 pmc 528930 cite journal author Luboshits G, Benayahu D title MS KIF18A, new kinesin ... The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression ... more details
PBB geneid 9928 Kinesin like protein KIF14 is a protein that in humans is encoded by the KIF14 gene . ref name pmid7584044 cite journal author Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S title Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes KIAA0041 KIAA0080 deduced by analysis of cDNA clones from human cell line KG 1 journal DNA Res volume 1 issue 5 pages 223 9 year 1995 month Dec pmid 7584044 pmc doi 10.1093 dnares 1.5.223 ref ref name entrez cite web title Entrez Gene KIF14 kinesin family member 14 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 9928 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Nakagawa T, Tanaka Y, Matsuoka E, et al. title Identification and classification of 16 new kinesin superfamily KIF proteins in mouse genome. journal Proc. Natl. Acad. Sci. U.S.A. volume 94 issue 18 pages 9654 9 year 1997 pmid 9275178 doi 10.1073 pnas.94.18.9654 pmc 23244 cite journal author Strausberg RL, Feingold EA, Grouse LH, et al. title Generation and initial analysis of more than 15,000 full length human and mouse cDNA sequences. journal Proc. Natl. Acad. Sci. U.S.A. volume 99 issue 26 pages 16899 903 year 2003 pmid 12477932 doi 10.1073 pnas.242603899 pmc 139241 cite journal author Corson TW, Huang A, Tsao MS, Gallie BL title KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers. journal Oncogene volume 24 issue 30 pages 4741 53 year 2005 pmid 15897902 doi 10.1038 sj.onc.1208641 cite journal author Gruneberg U, Neef R, Li X, et al. title KIF14 and citron kinase act together ... Carleton M, Mao M, Biery M, et al. title RNA interference mediated silencing of mitotic kinesin KIF14 ... more details
Orphan date February 2009 PBB geneid 9585 Kinesin like protein KIF20B is a protein that in humans is encoded by the KIF20B gene . ref name pmid8885239 cite journal author Matsumoto Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM title Identification of novel M phase phosphoproteins by expression cloning journal Mol Biol Cell volume 7 issue 9 pages 1455 69 year 1997 month Jan pmid 8885239 pmc 275994 doi ref ref name pmid8290587 cite journal author Westendorf JM, Rao PN, Gerace L title Cloning of cDNAs for M phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope journal Proc Natl Acad Sci U S A volume 91 issue 2 pages 714 8 year 1994 month Feb pmid 8290587 pmc 43019 doi 10.1073 pnas.91.2.714 ref ref name pmid11470801 cite journal author Kamimoto T, Zama T, Aoki R, Muro Y, Hagiwara M title Identification of a novel kinesin related protein, KRMP1, as a target for mitotic peptidyl prolyl isomerase Pin1 journal J Biol Chem volume 276 issue 40 pages 37520 8 year 2001 month Oct pmid 11470801 pmc doi 10.1074 jbc.M106207200 ref ref name entrez cite web title Entrez Gene MPHOSPH1 M phase phosphoprotein 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 9585 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions MPHOSPH1 has been shown to Protein protein interaction interact with PIN1 . ref name pmid11470801 cite journal last Kamimoto first T authorlink coauthors Zama T, Aoki R, Muro Y, Hagiwara M year 2001 month Oct. title Identification of a novel kinesin related protein, KRMP1, as a target for mitotic peptidyl prolyl isomerase Pin1 journal J. Biol. Chem. volume 276 issue 40 pages 37520 8 publisher location United States issn 0021 9258 pmid 11470801 doi ... phosphoprotein 1 is a human plus end directed kinesin related protein required for cytokinesis journal ... more details
A heavy chain is the large polypeptide subunit of a protein complex , such as a motor protein e.g. myosin , kinesin , or dynein or antibody or immunoglobulin . It commonly refers to the immunoglobulin heavy chain . The heavy H chain is the larger of the two types of chains that comprise a normal immunoglobulin or antibody molecule. The heavy chain portion of an antibody contains 2 regions the Fab Antigen binding portion and Fc Constant region confers biological activity such as phagocytosis of microorganisms, lysis, and clumping of organisms together . Amino Acid sequence determines the type of heavy chains and heavy chains define the isotype of Ig. Immunoglobulin G has gamma heavy chains, IgA has alpha heavy chains, IgM has mu heavy chains, IgD has delta heavy chains, and IgE has epsilon heavy chains. In contrast, all light chains are either kappa or lambda light chains, either of which may be found on any Ig molecule, regardless of isotype. Each Ig unit is made up of 2 heavy chains, 2 light chains, and has 2 antigen binding sites Category Protein complexes biology stub ca Cadena pesant es Cadena pesada id Rantai berat ... more details
Image Block banjo small.jpg frame Steve Block Dr. Steven M. Block born 1952 is a professor at Stanford University with a joint appointment in the departments of Biological Sciences and Applied Physics. In addition, he is a member of the scientific advisory group JASON , a senior fellow of Stanford s Freeman Spogli Institute for International Studies , and an amateur Bluegrass music bluegrass musician. Block received his B.A. and M.A. from Oxford University . He has been elected to the U.S. United States National Academy of Sciences National Academy of Sciences 2007 and the American Academy of Arts and Sciences 2000 , and is a winner of the Max Delbruck Prize http www.aps.org programs honors prizes delbruck.cfm of the American Physical Society 2008 , as well as the Single Molecule Biophysics Prize of the Biophysical Society 2007 . He served as President of the Biophysical Society during 2005 6. His graduate work was completed in the laboratory of Howard Berg at the University of Colorado at Boulder University of Colorado and Caltech . He received his Ph.D. in 1983 and went on to do postdoctoral research at Stanford. Since that time, Block has held positions at the Rowland Institute for Science , Harvard University , and Princeton University before returning to Stanford in 1999. As a graduate student, Block picked apart the adaptation Chemical kinetics kinetics involved in bacterial chemotaxis . As an independent scientist, Block has pioneered the use of optical tweezers , a technique developed by Arthur Ashkin , to study biological enzymes and polymers at the single molecule level. Work in his lab has led to the direct observation of the 8 nm steps taken by kinesin ref Svoboda K, Schmidt CF, Schnapp BJ, Block SM, http www.ncbi.nlm.nih.gov entrez query.fcgi?cmd Retrieve&db pubmed&dopt Abstract&list uids 8413650&query hl 1&itool pubmed docsum Direct observation of kinesin stepping by optical trapping interferometry , Nature. 1993 Oct 21 365 721 726. ref and the su ... more details
Orphan date November 2007 The mechanome ref FirstUse consists of the body, or ome ome , of data including cell and molecular processes relating to force and mechanical systems at molecular, cellular and tissue length scales, i.e. the fundamental machine code structures of the cell. The mechanome encompasses biological motors, like kinesin , myosin , RNAP, and Ribosome mechanical structures, like actin or the cytoskeleton , or processes, such as cytokinesis or chemotaxis . The mechanome seeks to understand the fundamental physical mechanical processes and events that are common to biological function. An example at the molecular level includes the common structural designs used by kinesin and myosin motor proteins such as dimer formation and mechanochemical cycles that control their function and lead to properties such as processivity. The mechanome assembles the common features of these motors regardless of the track microtubules, actin filaments, nucleotide based structures, membranes they move on. A cytoskeletal example includes structures such as actin filament networks and bundles that can form from a variety of actin binding proteins that cross link or bundle actin filaments leading to common mechanical changes of these structures. A cell machinery example includes common structures such as contractile ring formation formed by both actin and tubulin type structures leading to the same mechanical result of cell division. A definition of the Mechanome extending to cell organ body given by Prof. Roger Kamm, at the 5th World Congress of Biomechanics Munich, includes understanding The complete state of stress existing from tissues to cells to molecules. The biological state that results from the distribution of forces. Requires knowledge of the distribution of force throughout the cell organ body, the functional interactions between these stresses and the fundamental biological processes. Mechanomics is then the study of how forces are transmitted and the influence ... more details
PBB geneid 3835 Kinesin like protein KIF22 is a protein that in humans is encoded by the KIF22 gene . ref name pmid8599929 cite journal author Tokai N, Fujimoto Nishiyama A, Toyoshima Y, Yonemura S, Tsukita S, Inoue J, Yamamota T title Kid, a novel kinesin like DNA binding protein, is localized to chromosomes and the mitotic spindle journal EMBO J volume 15 issue 3 pages 457 67 year 1996 month Apr pmid 8599929 pmc 449964 doi ref ref name pmid11416179 cite journal author Miki H, Setou M, Kaneshiro K, Hirokawa N title All kinesin superfamily protein, KIF, genes in mouse and human journal Proc Natl Acad Sci U S A volume 98 issue 13 pages 7004 11 year 2001 month Jun pmid 11416179 pmc 34614 doi 10.1073 pnas.111145398 ref ref name entrez cite web title Entrez Gene KIF22 kinesin family member 22 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3835 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The protein encoded by this gene is a member of kinesin like protein family. This family of proteins are microtubule dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests an essential role in metaphase chromosome alignment and maintenance. ref name entrez Interactions KIF22 has been shown to Protein protein interaction interact with SIAH1 . ref name pmid11146551 cite journal last Germani first A authorlink coauthors Bruzzoni Giovanelli H, Fellous A, Gisselbrecht S, Varin Blank N, Calvo F year 2000 month Dec. title SIAH 1 interacts with alpha tubulin and degrades the kinesin Kid ... SIAH 1 interacts with alpha tubulin and degrades the kinesin Kid by the proteasome pathway during ... cite journal author Venkatesh LK, Gettemeier T, Chinnadurai G title A nuclear kinesin like protein interacts ... more details
PBB geneid 22920 Kinesin associated protein 3 is a protein that in humans is encoded by the KIFAP3 also known as KAP3 gene . ref name pmid8900189 cite journal author Shimizu K, Kawabe H, Minami S, Honda T, Takaishi K, Shirataki H, Takai Y title SMAP, an Smg GDS associating protein having arm repeats and phosphorylated by Src tyrosine kinase journal J Biol Chem volume 271 issue 43 pages 27013 7 year 1996 month Dec pmid 8900189 pmc doi 10.1074 jbc.271.43.27013 ref ref name entrez cite web title Entrez Gene KIFAP3 kinesin associated protein 3 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 22920 accessdate ref It is a non motor, accesssory subunit which co oligomerizes with the motor subunits KIF3A and KIF3B or KIF3C, to form heterotrimeric kinesin 2 motor proteins. Kinesin 2 KAP subunits were initially characterized in echinoderms and mice. ref name pmid8636215 cite journal author Wedaman KP, Meyer DW, Rashid DJ, Cole DG, Scholey JM title Sequence and submolecular localization of the 115 kD accessory subunit of the heterotrimeric kinesin II KRP85 95 complex journal J. Cell Biol. volume 132 issue 3 pages 371 80 year 1996 month February pmid 8636215 pmc 2120715 doi ref ref name pmid8710890 cite journal author Yamazaki H, Nakata T, Okada Y, Hirokawa N title Cloning and characterization of KAP3 a novel kinesin superfamily associated protein of KIF3A ... between human chromosome associated polypeptide SMC2 HCAP and KIF3A B, a kinesin superfamily protein ... the tumour suppressor APC and the kinesin superfamily journal Nat. Cell Biol. volume 4 issue 4 pages ... and associates with kinesin superfamily motor KIF3 journal EMBO J. volume 17 issue 1 pages 149 ... first8 Francis D. last9 Dreze first9 Matija cite journal author Brown CL title Kinesin 2 is a motor ... last7 Schroer first7 Trina A. cite journal author Haraguchi K title Role of the kinesin 2 family ... I title A role for kinesin 2 in COPI dependent recycling between the ER and the Golgi complex journal ... more details
PBB geneid 63971 Kinesin like protein KIF13A is a protein that in humans is encoded by the KIF13A gene . ref name pmid11106728 cite journal author Nakagawa T, Setou M, Seog D, Ogasawara K, Dohmae N, Takio K, Hirokawa N title A novel motor, KIF13A, transports mannose 6 phosphate receptor to plasma membrane through direct interaction with AP 1 complex journal Cell volume 103 issue 4 pages 569 81 year 2001 month Jan pmid 11106728 pmc doi 10.1016 S0092 8674 00 00161 6 ref ref name entrez cite web title Entrez Gene KIF13A kinesin family member 13A url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 63971 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions KIF13A has been shown to Protein protein interaction interact with AP1B1 . ref name pmid11106728 cite journal doi 10.1016 S0092 8674 00 00161 6 last Nakagawa first T authorlink coauthors Setou M, Seog D, Ogasawara K, Dohmae N, Takio K, Hirokawa N year 2000 month Nov. title A novel motor, KIF13A, transports mannose 6 phosphate receptor to plasma membrane through direct interaction with AP 1 complex journal Cell volume 103 issue 4 pages 569 81 publisher location UNITED STATES issn 0092 8674 pmid 11106728 bibcode oclc id url language format accessdate laysummary laysource laydate quote ref References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Maruyama K, Sugano S title Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. journal Gene volume 138 issue 1 2 pages 171 4 year 1994 pmid 8125298 doi 10.1016 0378 1119 94 90802 8 cite journal author Hillier LD, Lennon G, Becker M, et ... homologous to Drosophila kinesin 73 and candidate for schizophrenia. journal Genomics volume 74 issue ... 6p containing a kinesin like gene, RBKIN. journal Cancer Res. volume 62 issue 4 pages 967 71 ... more details
http www.find health articles.com rec pub 1726552 axonal transport kinesin cytoplasmic dynein.htm Axonal transport beyond kinesin and cytoplasmic dynein , Current opinion in neurobiology , 1991 ... of Dynein and Kinesin to translocate microtubules in Vitro , Toxicology and Applied Pharmacology ... more details
NCD Is A Three Letter Abbreviation Which May Mean National Creative Director Port Moresby National Capital District Papua New Guinea National Church Development National Clandestine Service National Cleavage Day National coverage determination s, which help the Centers for Medicare and Medicaid Services define medical necessity for Medicare United States Medicare beneficiaries nation wide. National Council on Disability National Center for Digitization, NCD National Center for Digitization Serbia Natural Church Development Uniforms of the Canadian Forces Naval Combat Dress Naval Combat Dress , a uniform of the Canadian Forces Naval Construction Division United States Navy U.S. Navy Negotiable certificate of deposit Nero CoverDesigner Document , a proprietary file format used to store custom cover elements created with the Nero CoverDesigner application Network Computing Devices , a company Kinesin Non Claret Disjunctional , a type of the molecular motor in the kinesin 14 family. Non communicable disease Non convergent discourse Non Convertible Debentures , an unsecured loan to a corporation that cannot be converted to equity Non Crystalline Diffraction Normalized Compression Distance New Christian Democrats Nieuwe Christen Democraten , a former Belgium Belgian political party, now part of the Flemish Liberals and Democrats National Corndog Day , an informal American holiday Nerd Compulsive Disorder Norton Change Directory Noncommunicable Disease , 64th World Health Assembly WHA , 2011. Nearly completely decomposable Markov chain Nearly completely decomposable , a property of some Markov chains disambig de NCD eo NCD it NCD nl NCD ja NCD pl NCD ... more details
Orphan date February 2009 PBB geneid 66008 Trafficking kinesin binding protein 2 is a protein that in humans is encoded by the TRAK2 gene . ref name pmid11161814 cite journal author Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J, Hayden MR title Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis ALS2 critical region at chromosome 2q33 q34 candidate genes for ALS2 journal Genomics volume 71 issue 2 pages 200 13 year 2001 month Feb pmid 11161814 pmc doi 10.1006 geno.2000.6392 ref ref name pmid16380713 cite journal author Gilbert SL, Zhang L, Forster ML, Anderson JR, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson MT, Wollmann RL, Lahn BT title Trak1 mutation disrupts GABA A receptor homeostasis in hypertonic mice journal Nat Genet volume 38 issue 2 pages 245 50 year 2006 month Jan pmid 16380713 pmc doi 10.1038 ng1715 ref ref name entrez cite web title Entrez Gene TRAK2 trafficking protein, kinesin binding 2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 66008 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions TRAK2 has been shown to Protein protein interaction interact with Kir2.1 ref name pmid16895905 cite journal last Grishin first Anatoly authorlink coauthors Li Hui, Levitan Edwin S, Zaks Makhina Elena year 2006 month Oct. title Identification of gamma aminobutyric acid receptor interacting factor 1 TRAK2 as a trafficking factor for the K channel Kir2.1 journal J. Biol. Chem. volume 281 issue 40 pages 30104 11 publisher location United States ... in vivo and in vitro with kinesin. journal J. Biol. Chem. volume 280 issue 15 pages 14723 ... title Mapping the GRIF 1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF 1 as an adaptor ... more details
The Nesprins nuclear envelope spectrin repeat ref http jcs.biologists.org cgi content abstract 114 24 4485 ref are a family of proteins that are found primarily in the outer nuclear membrane . Nesprin 1 and 2 bind to the actin filaments . Citation needed date September 2009 Nesprin 3 binds to plectin , which is bound to the intermediate filaments , ref cite journal pmid 16330710 year 2005 month Dec last1 Wilhelmsen first1 K last2 Litjens last3 Kuikman last4 Tshimbalanga last5 Janssen last6 Van Den Bout last7 Raymond last8 Sonnenberg title Nesprin 3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin volume 171 issue 5 pages 799 810 issn 0021 9525 doi 10.1083 jcb.200506083 journal The Journal of cell biology url http www.jcb.org cgi pmidlookup?view long&pmid 16330710 format Free full text first2 SH first3 I first4 N first5 H first6 I first7 K first8 A pmc 2171291 ref while nesprin 4 interacts with kinesin 1 . ref cite journal pmid 19164528 year 2009 month Feb last1 Roux first1 KJ last2 Crisp last3 Liu last4 Kim last5 Kozlov last6 Stewart last7 Burke title Nesprin 4 is an outer nuclear membrane protein that can induce kinesin mediated cell polarization volume 106 issue 7 pages 2194 9 issn 0027 8424 doi 10.1073 pnas.0808602106 journal Proceedings of the National Academy of Sciences of the United States of America url http www.pnas.org cgi pmidlookup?view long&pmid 19164528 format Free full text first2 ML first3 Q first4 D first5 S first6 CL first7 B pmc 2650131 ref See also SYNE1 SYNE2 References reflist Category Proteins protein stub ... more details
File Galactose 1 phosphate uridylyltransferase 1GUP.png thumb right Cartoon diagram of a dimer of Escherichia coli galactose 1 phosphate uridylyltransferase GALT in complex with UDP galactose stick models . Potassium, zinc, and iron ions are visible as purple, gray, and bronze colored spheres respectively. In biochemistry , a dimer is a macromolecular Complex chemistry complex formed by two, usually covalent bond non covalently bound , macromolecule s like protein s or nucleic acid s. It is a Protein quaternary structure quaternary structure of a protein. A homo dimer would be formed by two identical molecule s process called homodimerization . A hetero dimer would be formed by two different macromolecules process called heterodimerization . Most dimers in biochemistry are not connected by covalent bond s with the exception of disulfide bridge s. An example of this would be the enzyme reverse transcriptase , which is made of two different amino acid chains. ref cite journal journal J. Med. Chem. year 2006 volume 49 issue 16 pages 4834 4841 doi 10.1021 jm0604575 title Structure Activity Relationships of 2 ,5 Bis O tert butyldimethylsilyl d ribofuranosyl 3 spiro 5 4 amino 1 ,2 oxathiole 2 ,2 dioxide thymine Derivatives as Inhibitors of HIV 1 Reverse Transcriptase Dimerization author Nicolas Sluis Cremer, Noureddine Hamamouch, Ana San F lix, Sonsoles Vel zquez, Jan Balzarini, and Mar a Jos Camarasa pmid 16884295 ref Some proteins contain specialized domains to ensure dimerization dimerization domains . Examples Antibody Antibodies Receptor tyrosine kinase s Transcription factor s Leucine zipper motif proteins Nuclear receptor s 14 3 3 protein s G protein coupled receptor s G protein subunit dimer Kinesin Triosephosphateisomerase TIM Alcohol dehydrogenase Factor XI Factor XIII Toll like receptor Fibrin ogen References reflist See also Dimer Protein trimer ProtCID DEFAULTSORT Protein dimer Category Proteins Category Dimers chemistry Biochem stub es D mero biolog a ... more details
Infobox protein family Symbol FHA Name FHA domain image PDB 2csw EBI.jpg width caption solution structure of the fha domain of human ubiquitin ligase protein rnf8 Pfam PF00498 Pfam clan CL0357 InterPro IPR000253 SMART PROSITE PDOC50006 MEROPS SCOP 1qu5 TCDB OPM family OPM protein CAZy CDD In molecular biology, the forkhead associated domain FHA domain is a phosphopeptide recognition protein domain domain found in many regulatory protein s. ref name pmid7482699 cite journal author Hofmann K, Bucher P title The FHA domain a putative nuclear signalling domain found in protein kinases and transcription factors journal Trends Biochem. Sci. volume 20 issue 9 pages 347 9 year 1995 month September pmid 7482699 doi 10.1016 S0968 0004 00 89072 6 url ref It displays specificity for phosphothreonine containing epitopes but will also recognise phosphotyrosine with relatively high affinity. It spans approximately 80 100 amino acid residues protein folding folded into an 11 stranded beta sandwich, which sometimes contains small Alpha helical helical insertions between the loop biochemistry loops connecting the strands. ref name pmid11911881 cite journal author Durocher D, Jackson SP title The FHA domain journal FEBS Lett. volume 513 issue 1 pages 58 66 year 2002 month February pmid 11911881 doi url ref To date, genes encoding FHA containing protein proteins have been identified in eubacteria eubacterial and eukaryotic but not archaeal genomes . The domain is present in a diverse range of proteins, such as kinases , phosphatases , kinesin kinesins , transcription factors , RNA binding proteins and metabolism metabolic enzyme s which partake in many different cellular processes DNA repair , signal transduction , vesicular transport and protein degradation are just a few examples. References reflist External links ELM LIG FHA 1 ELM LIG FHA 2 InterPro content IPR000253 Category Protein families ... more details
Neurosci, 21, 393 409. ref The Calsyntenins were shown to interact with numerous proteins such as with kinesin .... Calsyntenin 1 docks vesicular cargo to kinesin 1. Mol Biol Cell 17, 3651 63. ref ref Araki et al ..., 5260 5. ref ref Konecna et al., 2006. Calsyntenin 1 docks vesicular cargo to kinesin 1. Mol Biol Cell ... Chem 278, 49448 58. ref ref Ludwig et al., 2009. Calsyntenins mediate TGN exit of APP in a kinesin ... to kinesin light chain KLC and thus to co determine transport of distinct cargo ,. ref Konecna et al., 2006. Calsyntenin 1 docks Vesicle biology and chemistry vesicular cargo to kinesin 1. Mol ... more details
PBB geneid 55605 Kinesin like protein KIF21A is a protein that in humans is encoded by the KIF21A gene . ref name pmid10225949 cite journal author Marszalek JR, Weiner JA, Farlow SJ, Chun J, Goldstein LS title Novel dendritic kinesin sorting identified by different process targeting of two related kinesins KIF21A and KIF21B journal J Cell Biol volume 145 issue 3 pages 469 479 year 1999 month Jun pmid 10225949 pmc 2185086 doi 10.1083 jcb.145.3.469 ref ref name entrez cite web title Entrez Gene KIF21A kinesin family member 21A url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 55605 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text KIF21A belongs to a family of plus end directed kinesin see MIM 600025 motor proteins. Neurons use kinesin and dynein see MIM 600112 microtubule dependent motor proteins to transport essential cellular components along axonal and dendritic microtubules. supplied by OMIM ref name entrez References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Yamada K, Hunter DG, Andrews C, Engle EC title A novel KIF21A mutation in a patient with congenital fibrosis of the extraocular muscles and Marcus Gunn jaw winking phenomenon journal Arch. Ophthalmol. volume 123 issue 9 pages 1254 1259 year 2005 pmid 16157808 doi 10.1001 archopht.123.9.1254 cite journal author Engle EC, Kunkel LM, Specht LA, Beggs AH title Mapping a gene for congenital fibrosis of the extraocular muscles to the centromeric region of chromosome 12 journal Nat. Genet. volume 7 issue 1 pages 69 73 year 1994 pmid 8075644 doi 10.1038 ng0594 69 cite journal author Ishikawa K title Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which ... K title Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular ... more details
Orphan date February 2009 PBB geneid 22906 Trafficking kinesin binding protein 1 is a protein that in humans is encoded by the TRAK1 gene . ref name pmid10470851 cite journal author Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O title Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro journal DNA Res volume 6 issue 3 pages 197 205 year 1999 month Oct pmid 10470851 pmc doi 10.1093 dnares 6.3.197 ref ref name pmid12435728 cite journal author Iyer SP, Akimoto Y, Hart GW title Identification and cloning of a novel family of coiled coil domain proteins that interact with O GlcNAc transferase journal J Biol Chem volume 278 issue 7 pages 5399 409 year 2003 month Feb pmid 12435728 pmc doi 10.1074 jbc.M209384200 ref ref name pmid16380713 cite journal author Gilbert SL, Zhang L, Forster ML, Anderson JR, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson MT, Wollmann RL, Lahn BT title Trak1 mutation disrupts GABA A receptor homeostasis in hypertonic mice journal Nat Genet volume 38 issue 2 pages 245 50 year 2006 month Jan pmid 16380713 pmc doi 10.1038 ng1715 ref ref name entrez cite web title Entrez Gene TRAK1 trafficking protein, kinesin binding 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 22906 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Hartley JL, Temple GF, Brasch MA title DNA Cloning Using In Vitro Site Specific Recombination journal Genome Res. volume 10 issue 11 pages 1788 95 year 2001 pmid 11076863 doi 10.1101 gr.143000 pmc 310948 cite journal ... in vivo and in vitro with kinesin journal J. Biol. Chem. volume 280 issue 15 pages 14723 32 ... more details
name FERM M FERM M FERM central domain, Pfam PF00373 ref align left KIF16B SNX23 KinesinKinesin motor domain kinesin motor SMAD FHA ref name SMAD FHA SMAD FHA SMAD FHA domain, InterPro IPR008984 ref ... more details
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