chembox verifiedrevid 450847443 ImageFile Leptomycin B.svg ImageSize IUPACName 2 E ,5 S ,6 R ,7 S ,9 R ,10 E ,12 E ,15 R ,16 Z ,18 E br 17 ethyl 6 hydroxy 3,5,7,9,11,15 hexamethyl br 19 2 S ,3 S 3 methyl 6 oxo 2,3 dihydropyran br 2 yl 8 oxononadeca 2,10,12,16,18 pentaenoic acid OtherNames Section1 Chembox Identifiers InChI 1 C33H48O6 c1 9 28 14 15 29 24 5 13 16 31 36 39 29 19 22 3 12 10 11 21 2 17 ... Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Leptomycin B is a secondary metabolite produced by Streptomyces spp. Leptomycin B LMB was originally discovered as a potent ... 646 50 year 1983 pmid 6874586 doi ref . Leptomycin B was found to cause cell elongation of the fission ... of leptomycin. However, recent data shows that Leptomycin causes G1 cell cycle arrest in mammalian ... P. Singh, Weimin Gao year 2012 month March title Chemotherapeutic Sensitization of Leptomycin ... date November 2010 . Leptomycin B has been shown to be a potent and specific nuclear export inhibitor in human ref cite journal author Kudo N, Wolff B, Sekimoto T, et al. title Leptomycin B inhibition ... M, Horinouchi S, Beppu T title Leptomycin B targets a regulatory cascade of crm1, a fission yeast ... content 269 9 6320.abstract ref . Leptomycin B alkylates and inhibits CRM1 chromosomal region ... journal author Kudo N, Matsumori N, Taoka H, et al. title Leptomycin B inactivates CRM1 exportin 1 ... 10.1073 pnas.96.16.9112 url ref . In addition to antifungal and antibacterial activities, Leptomycin B blocks the cell cycle and is a potent anti tumor agent. At low nM concentrations, Leptomycin B blocks ... cite&retmode ref&cmd prlinks&id 10900010 ref . Leptomycin B also inhibits the export and translation ... s Citation needed date November 2010 . Leptomycin A LPA was discovered together with LMB. LMB is twice as potent as LPA. References references External links MeshName leptomycin B Original data copied with permission from http www.fermentek.co.il leptomycin B.htm Leptomycin B manufacturer product page ... more details
LMB as an abbreviation may stand for Low noise block downconverter , the receiving device of a parabolic satellite dish antenna of the type commonly used for satellite TV reception. Laboratory of Molecular Biology , a research institute in Cambridge, England Liga Mexicana de Beisbol , the Mexican Baseball League Left Mouse Button on a mouse computing La Martiniere College for Boys, Kolkata Lois McMaster Bujold , science fiction and fantasy author Line Mode Browser , the first multi platform web browser Leptomycin B, an inhibitor of protein export from the cell nucleus disambig de LMB fr LMD it LMB ... more details
natural product from the leptomycin family of antibiotics. It was first isolated in 1997 from ... Callyspongia.png frame center Figure 1. Marine sponge Callyspongia truncata Leptomycin Family of Antibiotics The leptomycin family includes several well known anti tumor antibiotics ref name Kobayashi ... absolute stereochemistry as leptomycin B, ref name Murakami4 ref name Kobayashi2 cite journal author ... synthesis of leptomycin B journal Tetrahedron Lett. volume 39 issue 45 pages 8291 8294 year 1998 ... with leptomycin B as well. ref name Murakami4 ref name Murakami5 cite journal author Murakami, N ... 1999 ref The anti tumor activity of leptomycin B and callystatin A arises because many NES cargo ..., and PKA. ref name Wolff cite journal author Wolff, B. Sanglier, J. J. Wang, Y. title Leptomycin B ... thumb left Figure 3. Schematic of inhibition of NES dependent nuclear transport by leptomycin antibiotics The most important role of leptomycin B is its inhibitory effect on the NES dependent .... Fujiwara, D. Nishikawa, M. Horinouchi, S. Beppu, T. title Leptomycin B targets a regulatory cascade ... cite journal author Yoshida, M. Nishikawa K. Nishi, K. Abe Horinouchi, S. Beppu, T. title Effects of leptomycin ..., S. Yoshida, M. title M. Leptomycin B Inhibition of Signal Mediated Nuclear Export by Direct Binding ... process and CRM1 exportin1 reenters the nucleus for more cargo binding. Leptomycin B and callystatin ..., S. title Leptomycin B inactivates CRM1 exportin 1 by covalent modification at a cysteine residue ... year 2008 doi 10.1002 ange.200803031 ref See also Leptomycin Polyketide synthase Nuclear export signal ... more details
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