The following is a list of notable proteins that are generated from recombinant DNA , using biomolecular engineering , focusing on those that are used in human and veterinary medicine. In many cases, recombinant human proteins have replaced the original animal derived version used in medicine. The prefix rh for human recombinant appears less and less in the literature. A much larger number of recombinantproteins is used in the research laboratory. These include both commercially available proteins for example most of the enzymes used in the molecular biology laboratory , and those that are generated in the course specific research projects. Human recombinants that largely replaced animal or harvested from human types Growth hormone Human growth hormone rHGH Humatrope from Eli Lilly and Company Lilly and Serostim from Serono replaced cadaver harvested human growth hormone Biosynthetic Insulin human insulin BHI Humulin from Eli Lilly and Company Lilly and Novolin from Novo Nordisk among others largely replaced bovine and porcine insulin for human therapy. Some prefer to continue using the animal sourced preparations, as there is some evidence that synthetic insulin varieties are more likely to induce Diabetic hypoglycemia Hypoglycemic unawareness hypoglycemia unawareness . Remaining manufacturers of highly purified animal sourced insulin include the U.K. s Wockhardt Ltd. headquartered in India , Poland s Polfa Tarchomin S.A., Argentina s Laboratorios Beta S.A., and China s Wanbang Biopharma Co. Follicle stimulating hormone FSH as a recombinant gonadotropin preparation replaced Serono s Pergonal which was previously isolated from post menopausal female urine Factor VIII Kogenate from Bayer replaced blood harvested factor VIII Human recombinants with recombination as only source Erythropoietin EPO Epogen from Amgen Granulocyte colony stimulating factor G CSF filgrastim sold ... Proteins Category Peptide hormones ... more details
transport Ferritin Chaperone protein Chaperone proteins GroEL Enzyme s See List of enzymes Complexes with multiple components including proteins Nucleosome Ribonucleoprotein generic Signal recognition ... Genes Category ProteinsProteinsList of enzymes NPW PEGylation Protein design Protein family Structural domain Wikipedia MeSH D12.776 Medical Subject Headings classification of proteins Protein topics Expand list date August 2008 Category Molecular biology Category Cell biology Category Proteins ...A list of protein s and protein complex es . This list aims to organize information on the protein universe. All proteins can be found in the human proteome unless marked with a . If a protein has an Enzyme Commission number EC number , it should be on List of enzymes and not on this page, even if it fits into one of the categories below. For more information about categorizing protein types , see List of types of proteins . Fibrous protein s Cytoskeleton Cytoskeletal proteins Actin Arp2 3 Coronin Dystrophin FtsZ Keratin Myosin Spectrin Tau protein Tubulin Collagen Extracellular matrix Extracellular matrix proteins Collagen Elastin F spondin Pikachurin Globular protein s Blood plasma Plasma proteins Serum Amyloid P Component Serum albumin Coagulation Coagulation factors See also nowiki nowiki Template Coagulation Coagulation nowiki nowiki Complement system Complement proteins C1 inhibitor C3 convertase Factor VIII Factor XIII Fibrin Protein C Protein S Protein Z Protein Z related protease inhibitor Thrombin Von Willebrand Factor Acute phase protein s C reactive protein Hemoproteins Cell adhesion Cadherin Ependymin Integrin NCAM Selectin Transmembrane transport proteins Ion pumping enzymes ... channel Synport Antiport proteins Glucose transporter Hormones and growth factor s Epidermal ... Transcription Regulation CI protein Transcription regulatory proteins that are receptors are in the receptors section. C myc FOXP2 FOXP3 MyoD P53 Immune system Immune system proteins Antibody Immunoglobins ... more details
Recombinant may refer to A recombinant organism an organism that contains a different combination of Allele alleles from either of its parents. Recombinant DNA a form of artificial DNA Recombinant virus a virus formed by recombining genetic material VRLA , a valve regulated lead acid VRLA battery that is also referred to as a recombinant battery InSoc Recombinant , an album by synthpop band Information Society See also Recombination disambiguation disambig de Rekombinant ... more details
A List of types of proteins is part of on going attempts to manage the large amounts of information concerning ... may be based on Protein structure structure as in CATH and SCOP . The List of types of proteins ... categories. Note There is also a List of proteins . Specific proteins may be listed there. This page see below is for descriptions of types of proteins. biological process unknown Used for the annotation of gene products whose process is not known or cannot be inferred. Proteins with no known ... List Of Types Of Proteins Category Proteins Category Protein classification ... GO.slims.shtml GO Slims list for GOA and whole proteome analysis format version 1.0 date 17 08 ... structural domains , source organism or subcellular location. Structural categories Proteins with unknown ... products whose localization is not known or cannot be inferred. Consider placing such proteins in Structural ... also includes associated proteins. BR . See the Category Membrane biology Membrane biology category of wikipedia. BR See the Category Membrane proteins Membrane proteins category of wikipedia. BR See the Category Integral membrane proteins Integral membrane proteins category of Wikipedia. chromosome A structure composed of a very long molecule of DNA and associated proteins e.g. histones that carries ... more specific functional categories further below for proteins than these general categories ... motor proteins are also in the Category Cytoskeleton cytoskeleton category . BR See the Wikipedia Motor protein article and the Category Motor proteins motor proteins category of Wikipedia. helicase ... proteins, nucleic acids and carbohydrates. See also catabolism . Proteolysis Protease Category EC 3.4 ... use macromolecule metabolism above for proteins, nucleic acids and carbohydrates. kinase activity Catalysis ... Cytoskeleton Cytoskeleton category . extracellular matrix A layer consisting mainly of proteins especially ... such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. As in , but not restricted ... more details
and research . Today, recombinantproteins and other products that result from the use of rDNA ... the tissues of whole organisms. Recombinantproteins are widely used as reagents in laboratory ...Recombinant DNA rDNA molecules are DNA sequences that result from the use of laboratory methods molecular ... that would not otherwise be found in biological organisms. Recombinant DNA is possible because DNA ... DNA is replicated along with the host DNA. Introduction Recombinant DNA molecules are sometimes ... to the production of sticky and blunt ends . The DNA sequences used in the construction of recombinant ... into recombinant molecules. Using recombinant DNA technology and synthetic DNA, literally any DNA sequence may be created and introduced into any of a very wide range of living organisms. Proteins that result from the expression of recombinant DNA within living cells are termed List of recombinantproteinsrecombinantproteins . When recombinant DNA encoding a protein is introduced into a host organism, the recombinant protein will not necessarily be produced Citation needed date September 2011 . Expression of foreign proteins requires the use of specialized expression vector s and often ... 2011 Recombinant DNA differs from genetic recombination in that the former results from artificial ... of existing DNA sequences in essentially all organisms. Creating recombinant DNA main Molecular cloning Image recombinant formation of plasmids.svg thumb 280px right Construction of recombinant DNA ... is the laboratory process used to create recombinant DNA. ref name isbn0 201 75054 6 cite book author ... book author Watson, James D. title Recombinant DNA Genes and Genomes A Short Course publisher W.H. ... PCR replicates DNA in the test tube, free of living cells. Formation of recombinant DNA requires ... in inserting foreign DNA, identifying cells that contain recombinant DNA, and, where appropriate ... Creation of recombinant DNA, 5 Introduction of recombinant DNA into the host organism, 6 Selection ... more details
This is a list of scientists who participated in the 1964 Evolving Genes and Proteins symposium, a landmark ... Bryson and Henry J. Vogel, editors. Evolving Genes and Proteins A Symposium Held at the Institute of Microbiology ... ntsh 5 Part V, Evolution of Proteins III Chairman sortname Samuel Ajl Albert Einstein Medical ... National Institutes of Health ntsh 3 Part III, Evolution of Proteins I Chairman sortname Peter ..., Evolution of Proteins I Constancy and Variability of Protein Structure in Respiratory and Viral Proteins ... ntsh 3.21 Part III, Evolution of Proteins I Evolution of Hemoglobin in Primates sortname Vina ... ntsh 10 none sortname M. DeLuca Johns Hopkins University ntsh 5.23 Part V, Evolution of Proteins ... sortname J. A. DeMoss University of California, San Diego ntsh 5.12 Part V, Evolution of Proteins ... Part IV, Evolution of Proteins II Comparative Aspects of the Structure and Function of Phosphoglucomutase ... 10 none sortname Sidney W. Fox University of Miami ntsh 5.5 Part V, Evolution of Proteins III Experiments ... Part V, Evolution of Proteins III The Role of Mutations in Evolution sortname Jaques Fresco Princeton ... ntsh 4.13 Part IV, Evolution of Proteins II Comparative Aspects of the Structure and Function of Phosphoglucomutase ... of Proteins II Comparative Aspects of the Structure and Function of Phosphoglucomutase sortname ... Duke University Medical Center ntsh 4.12 Part IV, Evolution of Proteins II Comparative Aspects ... of Medicine ntsh 3.22 Part III, Evolution of Proteins I Evolution of Hemoglobin in Primates sortname ... of Proteins II Comparative Aspects of the Structure and Function of Phosphoglucomutase sortname ... sortname Nathan O. Kaplan Brandeis University ntsh 4.3 Part IV, Evolution of Proteins II Evolution ... of Proteins III On the Evolution of the Lactose Utilization Gene System in Enteric Bacteria sortname Emanuel Margoliash Abbott Laboratories ntsh 4.2 Part IV, Evolution of Proteins II Structural ... ntsh 10 none sortname William D. McElroy Johns Hopkins University ntsh 5.21 Part V, Evolution of Proteins ... more details
This is a list of genes, proteins or receptors named A1 or Alpha 1 Actin, alpha 1 Actinin, alpha 1 Adaptor related protein complex 2, alpha 1 Aldehyde dehydrogenase 3 family, member A1 Aldehyde dehydrogenase 4 family, member A1 Aldehyde dehydrogenase 5 family, member A1 Aldehyde dehydrogenase 6 family, member A1 Aldehyde dehydrogenase 9 family, member A1 Aldehyde dehydrogenase 18 family, member A1 Aldo keto reductase family 1, member A1 Alpha 1 microglobulin bikunin precursor Apolipoprotein A1 and ApoA 1 Milano ATPase, H transporting, lysosomal V0 subunit a1 ATPase, Na K transporting, alpha 1 ATP synthase, H transporting, mitochondrial F1 complex, alpha 1 BCL2 related protein A1 Butyrophilin, subfamily 1, member A1 Butyrophilin, subfamily 3, member A1 Capping protein actin filament muscle Z line, alpha 1 Carboxypeptidase A1 Casein kinase 1, alpha 1 Casein kinase 2, alpha 1 Catenin cadherin associated protein , alpha 1 Centaurin, alpha 1 Cholinergic receptor, nicotinic, alpha 1 Coagulation factor XIII, A1 polypeptide collagen, type I, alpha 1 collagen, type II, alpha 1 Collagen, type III, alpha 1 Collagen, type IV, alpha 1 Collagen, type V, alpha 1 Collagen, type VI, alpha 1 Collagen, type VII, alpha 1 Collagen, type VIII, alpha 1 Collagen, type IX, alpha 1 Collagen, type X, alpha 1 Collagen, type XI, alpha 1 Collagen, type XII, alpha 1 Collagen, type XIII, alpha 1 Collagen, type XIV, alpha 1 Collagen, type XV, alpha 1 Collagen, type XVI, alpha 1 Collagen, type XVII, alpha 1 Collagen, type XVIII, alpha 1 Collagen, type XIX, alpha 1 Collagen, type XXV, alpha 1 Collagen, type XXVII, alpha 1 Crystallin, beta A1 Cyclic nucleotide gated channel alpha 1 Cyclin A1 Cytochrome P450, family 1, member A1 Defensin, alpha 1 Dystrophin associated protein A1 Ephrin A1 Eukaryotic translation elongation factor 1 alpha 1 Family with sequence similarity 13, member A1 Family with sequence ... dihydroflavonols into flavan 4 ols in the phlobaphene metabolic pathway proteins Alpha 1 antitrypsin ... more details
A recombinant virus is a virus produced by recombining pieces of DNA using recombinant DNA technology. This may be used to produce vaccine viral vaccine s or gene therapy vectors. It is also used to refer to naturally occurring recombination between virus genomes in a cell infected by more than one virus strain. This occurs either by homologous crossing over of the nucleic acid strands or by reassortment of genomic segments. Both these and mutation within the virus have been suggested as ways in which influenza and other viruses evolve. An example of a recombinant virus is Western equine encephalitis virus WEE , which is a recombinant virus between two other closely related yet distinct encephalitis viruses. In addition, reassortment is most important for pandemic influenza viruses. See also Reassortment Mutation References http www.cdc.gov ncidod eid vol10no4 03 0396.htm Recombination Resulting in Virulence Shift in Avian Influenza Outbreak, Chile. Suarez et al 2009 http mbe.oxfordjournals.org cgi content abstract 26 1 177?maxtoshow &HITS 1&hits 1&RESULTFORMAT &andorexacttitle phrase&titleabstract H5N1&andorexacttitleabs and&andorexactfulltext and&searchid 1&usestrictdates yes&resourcetype HWCIT&ct Homologous Recombination as an Evolutionary Force in the Avian Influenza A Virus. He at al 2008 External links http www.pbs.org wgbh amex influenza sfeature drjeffrey8.html Dr. Jeffery Taubenberger on A Recombinant Virus http pathmicro.med.sc.edu mhunt genet.htm Viral Genetics http www.cdc.gov flu avian gen info transmission.htm Transmission of Influenza A Viruses Between Animals and People Virus topics DEFAULTSORT Recombinant Virus Category Virology Category Influenza ... more details
Infobox Album See Wikipedia WikiProject Albums Name InSoc Recombinant Type Remix Artist Information Society band Information Society Cover Released April 6, 1999 Recorded Genre Synthpop Length Label Cleopatra Records Cleopatra Producer Reviews Last album Don t Be Afraid album Don t Be Afraid br 1997 This album InSoc Recombinant br 1999 Next album strange haircuts cardboard guitars and computer samples br 2001 InSoc Recombinant is a compilation album of the greatest hits by synthpop band Information Society band Information Society , in various remix remixed versions. It includes, as a bonus, a CD ROM with five music videos. Track listing What s on Your Mind Pure Energy CKB Remix Closing In Rosetta Stone band Rosetta Stone Mix Peace & Love, Inc. Biokraft Mix Think Information Society song Think Spahn Ranch band Spahn Ranch Mix What s on Your Mind? Pure Energy Girl Eats Boy Mix Walking Away Le ther Strip Mix Going Going Gone Razed in Black Mix What s on Your Mind? Pure Energy Judson Leach and the Exhibition Mix Empty Astralasia Mix Ending World Electric Hellfire Club Mix On the Outside THC band THC Mix What s on Your Mind? Pure Energy David J Remix The Brazilian release included InSoc s cover of Madonna entertainer Madonna s Express Yourself Madonna song Express Yourself previously released in the compilation Virgin Voices A Tribute To Madonna . http www.insoc.com.br mix recomb.php All the remixes of What s On Your Mind? Pure Energy were previously released on a 12 single the year before. Video listing What s on Your Mind Pure Energy Walking Away Repetition Think Peace & Love, Inc Category Information Society albums Category 1999 remix albums 1990s electronic album stub 1990s compilation album stub ... more details
Orphan date February 2009 Avimer Proteins are multimeric binding proteins or peptides engineered using in vitro exon shuffling and phage display. Multiple binding domains are linked, resulting in greater affinity and specificity compared to single epitope immunoglobin domains. ref http www.nature.com nbt journal v23 n12 abs nbt1166.html Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains Nature Biotechnology Bot generated title ref These properties make avimer proteins extremely useful as potential tools and therapeutics. References reflist Expert Opinion on Investigational Drugs June 2007, Vol. 16, No. 6, Pages 909 917 Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains Nature Biotechnology 23, 1556 1561 2005 Avimers hold their own Nature Biotechnology 23, 1493 1494 2005 DEFAULTSORT Avimer Proteins Category Peptides ... more details
mobility of proteins. Somewhat larger families of recombinant inbred strains were generated ...refimprove date June 2011 A recombinant inbred strain or recombinant inbred line is an organism with chromosomes that incorporate an essentially permanent set of recombination events between chromosomes inherited from two or more inbred strain s. Families of recombinant inbred strains numbering from ... to differences in phenotype in model organisms. Recombinant inbred strains or lines ... elegans C. elegans and rat . History The origins and history of recombinant inbred strains are described ... and recombinant inbred lines journal Genetics journal Genetics year 2007 volume 176 issue 2 pages ... utility of recombinant inbred strains is mapping analysis of complex polygenic traits was obvious ... large effects quasi Mendelian loci . One of the initial motivations to use recombinant inbred strains ... of recombinant inbred mice high resolution consensus maps for complex trait analysis journal ... author Broman KW title The genomes of recombinant inbred lines journal Genetics year 2005 volume ... of using recombinant inbred strains and other genetic reference panels shifted to the ability to assemble ... and plant and animal research. Use Recombinant inbred strains are now widely used in systems ... of recombinant inbred strains under several different conditions e.g., baseline environment versus ... and environmental effects and their interactions. Genetics Chromosomes of recombinant inbred strains ... from the parental strains. In the case of a typical mouse recombinant inbred strain made by crossing maternal strain BALB cBy C with paternal strain C57BL 6By B called a CXB recombinant inbred strain ... of recombinant inbred strains, the greater the power and resolution with which phenotypes can be mapped ... of recombinant inbred strains for mapping was significantly improved thanks to higher density ... extant mouse and rat recombinant inbred strains were regenotyped at many thousands of SNP markers, providing ... more details
Refimprove date July 2007 Expert subject Medicine date November 2008 Blood proteins , also termed serum proteins or plasma proteins , are protein s found in blood plasma . Serum total protein in blood is 7g dl. They serve many different functions, including circulatory transport molecules for lipids hormones, vitamins and metals enzymes, complement components, protease inhibitors , and kinin precursor s regulation of Non cellular life acellular activity and functioning and in the immune system. Separating serum proteins by electrophoresis is a valuable diagnostic tool as well as a way to monitor clinical progress. Often mentioned blood proteins Image Hemoglobin.jpg thumb 100px Structure of hemoglobin class wikitable Blood protein Normal level Function serum albumin Albumin s 3.5 5.0 g dl 60 create oncotic pressure and transports other molecules immunoglobulin s 1.0 1.5 g dl 18 participate in immune system Fibrinogen s 0.2 0.45 g dl 4 blood coagulation alpha 1 antitrypsin neutralize trypsin that has leaked from the digestive system Regulation of gene expression Regulatory proteins 1 Regulation of gene expression Regulation of few gene expression Other types of blood proteins include ... Ceruloplasmin Transferring C3 C4 Beta 2 microglobulin Beta lipoprotein Gamma globulin proteins ... Mannan binding lectin MBL or MBP All the plasma proteins are synthesized in liver except gamma globulins . 60 of plasma proteins are made up of the protein albumin, which are major contributors ... make up 35 of plasma proteins and are used in the transport of ions, hormones and lipids assisting ... into insoluble fibrin. Regulatory proteins which make up less than 1 of plasma proteins are proteins such as enzymes, proenzymes and hormones. Current research regarding blood plasma proteins is centered ... NL and Anderson NG title High Resolution Two Dimensional Electrophoresis of Human Plasma Proteins ... edited by Wendy Arneson, Jean Brickell. Category Blood proteins Category Proteins Category ... more details
Proteins are present in wine. The most common protein s include thaumatin like proteins and chitinase s and have a role in the formation of turbidity haze ref Thaumatin like proteins and chitinases, the haze forming proteins of wine, accumulate during ripening of grape Vitis vinifera berries and drought stress does not affect the final levels per berry at maturity. Pocock KF, Hayasaka Y, McCarthy MG and Waters EJ, J Agric Food Chem. 2000 May, 48 5 , pages 1637 1643, PMID 10820071 , doi 10.1021 jf9905626 ref especially visible in white wine . ref Roles of grape thaumatin like protein and chitinase in white wine haze formation. Marangon M, Van Sluyter SC, Neilson KA, Chan C, Haynes PA, Waters EJ and Falconer RJ, J Agric Food Chem. 2011 Jan 26, 59 2 , pages 733 740, PMID 21189017 , doi 10.1021 jf1038234 ref The quantity of haze forming is dependant on the quantity of phenolic content in wine phenolics in the wine . ref Effects of Protein Polyphenol Interactions on Beverage Haze, Stabilization, and Analysis. Karl J. Siebert, J. Agric. Food Chem., 1999, 47 2 , pages 353 362, doi 10.1021 jf980703o ref Some of those proteins are considered nuisance . Some of them are grape pathogenesis related protein s. ref Nuisance Proteins of Wine Are Grape Pathogenesis Related Proteins. Elizabeth J. Waters, Neil J. Shirley and Patrick J. Williams, J. Agric. Food Chem., 1996, 44 1 , pages 3 5, doi 10.1021 jf9505584 ref Those proteins have been identified by mass spectrometry and originate from grape, yeast, bacteria and fungi. ref Profiling of Soluble Proteins in Wine by Nano High Performance Liquid ... 7258 7263, doi 10.1021 jf048940g ref These proteins are unstable when submitted to heat but can be removed ... Unstable Proteins in Wine. I. Characterization and Removal by Bentonite Fining and Heat Treatment. Juinn ..., pages 11 16 ref process called clarification and stabilization of wine . Proteins residues from ... Proteins Category Wine chemistry protein stub wine stub ... more details
The family of non collagen ous protein s known as SIBLING proteins , standing for s mall i ntegrin b inding li gand, N linked g lycoprotein, are components of the extracellular matrix of bone and dentin . Evidence shows that these proteins play key roles in the Mineralization biology mineralization of these tissues. ref name Qin Qin, C. http cro.sagepub.com cgi content abstract 15 3 126 POST TRANSLATIONAL MODIFICATIONS OF SIBLING PROTEINS AND THEIR ROLES IN OSTEOGENESIS AND DENTINOGENESIS Crit Rev Oral Biol Med 2004 15 3 126 136 ref The following are categorized as SIBLING proteins ref name Qin ref Chaplet, M. http cat.inist.fr ?aModele afficheN&cpsidt 15005341 Dentin matrix protein 1 is expressed in human lung cancer 2003, vol. 18, no8, pp. 1506 1512 ref osteopontin OPN bone sialoprotein BSP dentin matrix protein 1 DMP1 dentin sialophosphoprotein protein dentin sialophosphoprotein DSPP matrix extracellular phosphoglycoprotein MEPE The genes coding for members of the SIBLING protein family are similarly organized and are all located on human chromosome 4q21 23. ref name Rittling Rittling, S.R. and Denhardt, D.T. http www.ncbi.nlm.nih.gov pubmed 10213864 OSTEOPONTIN FUNCTION IN PATHOLOGY LESSONS FROM OSTEOPONTIN DEFICIENT MICE Exp Nephrol 1999 7 103 113 ref References Reflist Category Glycoproteins Category Extracellular matrix proteins sr SIBLING proteini ... more details
Copper proteins are proteins that contain one or more copper ions as prosthetic group s. The metal centres in the copper proteins can be classified into several types ref citation first1 Richard H. last1 Holm authorlink1 Richard H. Holm first2 Pierre last2 Kennepohl first3 Edward I. last3 Solomon title Structural and Functional Aspects of Metal Sites in Biology journal Chemical Reviews volume 96 issue 7 pages 2239 2314 year 1996 doi 10.1021 cr9500390 ref Type I copper centres T1Cu are characterized by a single copper atom coordinated by two histidine residues and a cysteine residue in a trigonal planar structure, and a variable axial ligand . In Plastocyanin family of copper binding proteins class I T1Cu proteins e.g. amicyanin , plastocyanin and pseudoazurin the axial ligand is the sulfur of methionine , whereas aminoacids other than methionine e.g. glutamine give rise to class II T1Cu copper proteins. Azurin s contain the third type of T1Cu centres besides a methionine in one axial position, they contain a second axial ligand a Carbonyl carbonyl group of a glycine residue . T1Cu containing proteins are usually called cupredoxins , and show similar three dimensional structures, relatively high reduction potentials 250 mV , and strong absorption near 600 nm due to sulfur S copper Cu Luminophore charge transfer , which usually gives rise to a blue colour. Cupredoxins are therefore often called blue copper proteins . This may be misleading, since some T1Cu centres also absorb around 460 nm and are therefore green. When studied by Electron spin resonance EPR spectroscopy, T1Cu ... citation first Judith P. last Klinman title Mechanisms Whereby Mononuclear Copper Proteins Functionalize ... by three histidine residues. These proteins exhibit no EPR signal due to strong antiferromagnetic ... oxygen transporting proteins e.g. hemocyanin and tyrosinase . ref Lewis, E. A. and Tolman, W. B., Reactivity ... in health References references Category Copper proteins Category Peripheral membrane proteins de Kupferproteine ... more details
Orphan date April 2012 Infobox journal title Proteins Structure, Function, and Bioinformatics cover File Proteins journal .gif editor Bertrand Garcia Moreno discipline Proteins science peer reviewed language formernames abbreviation publisher Wiley Intescience country U.S.A. frequency Monthly, except semimonthly in Feb., May, Aug., and Nov history 1986 present openaccess license impact 3.085 impact year 2009 website http onlinelibrary.wiley.com journal 10.1002 ISSN 1097 0134 link1 link1 name link2 link2 name RSS atom JSTOR OCLC 13196210 LCCN 90655008 CODEN ISSN 1097 0134 eISSN boxwidth General information Proteins Structure, Function, and Bioinformatics is a monthly, peer review ed, scientific journal , published by Wiley Interscience , which was established in 1986 Vol. 1, No. 1 by Cyrus Levinthal . The Editor in Chief is Dr. Bertrand Garcia Moreno Johns Hopkins University . According to Journal Citation Reports the 2009 impact factor for this journal is 3.085. ref name Scope pr Publishing formats are original research reports, short communications 4 pages , prediction reports, invited reviews, and topic proposals. In addition, Proteins includes a section entitled Section Notes 1 to 2 pages , describing a novel protein structure. ref name Scope pr This journal has alternate titles, and former variations in frequency. Other titles Because the subtitle varies, this journal has the following alternate titles ref name LCC ProteinsProteins, structure, function, and genetics Proteins, structure, function, and bioinformatics Structure, function, and genetics Structure, function, and bioinformatics ... journal 1097 0134 Proteins Structure Function and Bioinformatics accessdate 2010 08 26 ref Proteins, structure, function, and genetics 1991 2003 Proteins, structure, function, and bioinformatics . 2004 ... of Proteins is publishing original research on all topics regarding protein research. Analytical ... disciplines. ref name Scope pr Abstracting and indexing Proteins is indexed in the following databases ... more details
WJ title Plant viral movement proteins agents for cell to cell trafficking of viral genomes journal ... 0854.2000.010703.x Category Proteins protein stub ... more details
T title Phylogenetic analysis of AAA proteins journal J. Struct. Biol. volume 146 issue 1 2 pages 2 10 year 2004 pmid 15037233 doi 10.1016 j.jsb.2003.11.020 ref These proteins are involved in a range ... of AAA proteins is the coupling of chemical energy by ATPase , provided by ATP hydrolysis , to mechanical ... that form a ring shaped structure with a central pore. These proteins produce a molecular motor that couples ... in all organisms and they are essential for many cellular functions. One type of AAA Proteins ... for degradation. AAA type ATPases constitute a large family of enzymes. AAA proteins are characterised ... A and Walker B motifs . AAA proteins themselves belong to the superfamily of P loop NTPases. Domain structure of AAA type ATPases All AAA proteins have a mixed alpha beta domain that binds and hydrolyzes nucleotide. Most AAA proteins have a second domain that comprises the AAA module an all alpha ... proteins have additional domains that are used for oligomerization, substrate binding and or regulation. These domains can lie N or C terminal to the AAA module. Some classes of AAA proteins have an N ... proteins with two AAA domains, both are evolutionarily well conserved like in Cdc48 p97 . In others ... distantly related cellular regulators and termed AAA family of ATPases 112 . AAA proteins are involved ... to substrate protein. Prokaryotic AAAs AAA proteins are not restricted to eukaryote s. Prokaryotes have ..., which mediates protein degradation and recognition in E. coli . The basic recognition of proteins ... ClpX ClpY homologue of the HSP100 family of AAA proteins, the N and C terminal subdomains move ... AAA protein. Misfolded secretory proteins are exported from the endoplasmic reticulum ER and degraded by the ER associated degradation pathway ERAD . Nonfunctional membrane and luminal proteins ... that sort ubiquitinated membrane proteins by incorporating them into vesicles. This process ... its oligomerzation status and ATPase activity. Human proteins containing this domain AFG3L1 ... more details
FOX Forkhead box proteins are a family of transcription factor s that play important roles in regulating the expression of gene s involved in cell growth, proliferation, differentiation, and longevity . Many FOX proteins are important to embryonic development. ref name pmid17889656 cite journal author Tuteja G, Kaestner KH title SnapShot forkhead transcription factors I journal Cell volume 130 issue 6 pages 1160 year 2007 month September pmid 17889656 doi 10.1016 j.cell.2007.09.005 url ref ref name pmid17923097 cite journal author Tuteja G, Kaestner KH title Forkhead transcription factors II journal Cell volume 131 issue 1 pages 192 year 2007 month October pmid 17923097 doi 10.1016 j.cell.2007.09.016 url ref The defining feature of FOX proteins is the fork head domain forkhead box , a sequence of 80 to 100 amino acids forming a DNA motif motif that binds to DNA . This forkhead motif is also known as the Winged helix transcription factors winged helix due to the butterfly like appearance of the loops in the protein structure of the domain. ref name pmid12801727 cite journal author Lehmann OJ, Sowden JC, Carlsson P, Jordan T, Bhattacharya SS title Fox s in development and disease journal TRENDS in Genetics volume 19 issue 6 pages 339 344 year 2003 pmid 12801727 doi 10.1016 S0168 9525 03 00111 2 ref Forkhead genes are a subgroup of the helix turn helix class of proteins. Biological roles Many genes encoding FOX proteins have been identified. For example, the FOXF2 gene encodes forkhead box F2 , one of many human homologues of the Drosophila melanogaster transcription factor forkhead. FOXF2 is expressed in lung and placenta . Some FOX genes are downstream targets of the hedgehog ... Stressing the role of FoxO proteins in lifespan and disease journal Nat. Rev. Mol. Cell Biol. volume ..., FREAC, and fkh , but in 2000 a unified nomenclature was introduced that grouped the FOX proteins into subclasses ... links MeshName Forkhead Box Proteins Transcription factors g3 DEFAULTSORT Fox Proteins Category Transcription ... more details
FANC proteins are a group of proteins associated with Fanconi anemia . ref MeshName FANC Proteins ref ref name pmid19465921 cite journal author Naim V, Rosselli F title The FANC pathway and BLM collaborate during mitosis to prevent micro nucleation and chromosome abnormalities journal Nat. Cell Biol. volume 11 issue 6 pages 761 8 year 2009 month June pmid 19465921 doi 10.1038 ncb1883 ref ref name OchsSmith2007 cite book author1 Hans D. Ochs author2 C. I. Edvard Smith author3 Jennifer Puck title Primary immunodeficiency diseases a molecular and genetic approach url http books.google.com books?id pCDDYDhy03AC&pg PA431 accessdate 21 December 2010 year 2007 publisher Oxford University Press US isbn 9780195147742 pages 431 ref They are involved in DNA replication and damage response. ref name pmid19729998 cite journal author Naim V, Rosselli F title The FANC pathway and mitosis a replication legacy journal Cell Cycle volume 8 issue 18 pages 2907 11 year 2009 month September pmid 19729998 doi url http www.landesbioscience.com journals cc abstract.php?id 9538 ref Components include core protein complex FANCA , FANCB , Fanconi anemia, complementation group C FANCC , FANCE , FANCF , FANCG , FANCL , FANCM other BRCA1 FANCD1 , FANCD2 , FANCI , BRIP1 FANCJ , PALB2 FANCN , FANCP References reflist DNA repair Category DNA repair Category Protein groups biochemistry stub ... more details
Orphan date November 2006 Recombinant Human Dragon is an internet based multimedia installation exploring issues of cultural ownership and re use. It is also home to the musical artists Beastmaster Romance and The Earl of Bandwidth . Manifesto excerpts We too often confuse doing an activity with being entertained. We too readily accept passive entertainment as a substitute for active participation in culture, consumption as a substitute for production. We too often convince ourselves to be satisfied with cultural opportunities which ask us to invest nothing other than money. The project of recombinant cultural production asserts the necessity of hybrids, the impossibility of inventing anything completely new. Works of culture always borrow from, build off of, and make reference to past works, whether they like it or not. Originality is a myth that belongs with the epic works of 19th romanticism. Leave it there. You cannot create something from nothing. One needs raw materials. The process of creation requires appropriation. Influences Dadaism Situationist International Situationism External links http recombinanthumandragon.com Recombinant Human Dragon Website Category Artist groups and collectives Artist stub ... more details
File Paul Berg in 1980.jpg thumb right Paul Berg , a leading researcher in the field of recombinant DNA ... Sanger . The Asilomar Conference on Recombinant DNA was an influential academic conference conference organized by Paul Berg ref First recombinant DNA. The Human Genome Project. http www.genome.gov ... Statement of the Asilomar Conference on Recombinant DNA Molecules . Proc. Nat. Acad. Sci. Vol. 72, No. 6 ... to ensure the safety of recombinant DNA technology. The conference also placed scientific research ... recombinant Paul Berg and Maxine F. Singer. The recombinant DNA controversy Twenty years later . Proc ..., scientists worldwide had halted experiments using recombinant DNA technology, which entailed combining DNAs from different organisms. ref name asilomar ref name recombinant After the establishment of the guidelines ... 1995 , pp. 9011 12 ref Background recombinant DNA technology Recombinant DNA technology arose as a result ... that were reflected in new capacities to manipulate DNA. ref Susan Wright. Recombinant DNA Technology ... was recombinant DNA technology. Experimental design This technology entails the joining ... of the first individuals to develop recombinant DNA technology was a biochemist at Stanford by the name of Paul Berg. ref Paul Berg and Maxine F. Singer. The recombinant DNA controversy Twenty years later ... safety ramifications of this new technology. This committee, called the Committee on Recombinant DNA ... involving recombinant DNA technology. ref Carmen, Ira H. Cloning and the Constitution An Inquiry ..., 1985 ref Asilomar Conference Established principles The Asilomar Conference on Recombinant DNA ... in 1975. The main goal of the conference was to address the biohazards presented by recombinant ... , and Maxine F. Singer . Summary Statement of the Asilomar Conference on Recombinant DNA Molecules ... the use of biological barriers to limit the spread of recombinant DNA. Such biological barriers included ... information indicated that the recombinant DNA could not either alter appreciably the ecological ... more details
Orphan date February 2011 barelinks date June 2011 The Recombinant Immunotoxin Collaborative Group RICG is a group of scientists specialising in immunology, biochemistry and molecular biology from the United Kingdom and Italy. The group is working toward the development of genetically engineered immunotoxins made from monoclonal antibody fragments genetically fused to either saporin or Pseudomonas exotoxin PE for the treatment of human hematological malignancies such as leukaemia , lymphoma and multiple myeloma . The RICG was formed in 2005 and originally consisted of Dr Aldo Ceriotti and Dr M. Serena Fabbrini IBBA, CNR, Milan , Professor Marco Colombatti University of Verona , Professor Rodolfo Ippoliti University of L Aquila , Dr Alessandro Pini University of Siena and Drs David Flavell & Sopsamorn Flavell University of Southampton Medical School & Leukaemia Busters . Dr Alessandro Pini left the group in 2007. The RICG was successful in producing a range of recombinant immunotoxins based on the monoclonal antibodies 4KB128 and OKT10 targeting CD22 and CD38 , respectively on normal and malignant lymphoid cells. This development work was undertaken with funding from the UK based charity Leukaemia Busters ref http leukaemiabusters.org.uk ref under the direction of Dr David Flavell , the charity s Scientific Director ref http www.leukaemiabusters.org.uk pages background.aspx ref The group disbanded in 2009 due to funding difficulties following the global economic crisis but despite this the former members continue to collaborate in areas of mutual interest. In this respect some of the group members and their respective institutes have recently entered into a collaboration agreement with the Italian pharmaceutical company Domp ref http www.dompe.com website ref based in L Aquila, central Italy with the intention of developing one of the RICG produced recombinant immunotoxins for investigation in early phase clinical trials for patients with leukaemia and lymphoma. References ... more details
Enzo Paoletti and Dennis Panicali at the New York State department of Health, devised a Strategy to produce recombinant DNA vaccines by using genetic engineering techniques. They were able to transform ordinary smallpox vaccine into vaccines that may be able to prevent other diseases. What Paoletti and his colleague, Virologist Dennis Panicali, set out to do was to alter the DNA of cowpox virus by inserting a gene from another virus namely herpes, hepatitis B or influenza . These efforts resulted, amongst others in the development of a commercial Hepatitis B vaccine which is now widely used. ref References ref http www.time.com time magazine article 0,9171,921366,00.html Time Magazine article on Paoletti s work http www.thefreelibrary.com A vaccine for all seasons 3B genetic engineering is remodeling the... a03815488 Article on Paoletti s work http www.thefreelibrary.com A vaccine for all seasons 3B genetic engineering is remodeling the... a03815488 Paoletti s vaccine for herpes Category Italian inventions references Paoletti, Enzo, Bernard R. Lipinskas, Carol Samsonoff, Susan Mercer, and Dennis Panicali 1984 Construction of Live Vaccines Using Genetically Engineered Poxviruses Biological Activity of Vaccinia Virus Recombinants Expressing the Hepatitis B Virus Surface Antigen and the Herpes Simplex Virus Glycoprotein D Proc. Natl. Acad. Sci. USA 81 193 197 Panicali, Dennis, Stephen W. Davis, Randall L. Weinberg, Enzo Paoletti 1983 Construction of Live Vaccines by Using Genetically Engineered Poxviruses Biological Activity of Recombinant Vaccinia Virus Expressing Influenza Virus Hemagglutinin Proc. Natl. Acad. Sci. USA 80 5364 5368 US Patent 4722848 Method for immunizing animals with synthetically modified vaccinia virus ... more details
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