width 210 image2 lovastatin spacefill.png Clinical data tradename Mevacor Drugs.com drugs.com monograph lovastatin MedlinePlus a688006 pregnancy US X legal US Rx only routes of administration oral ... N Lovastatin is a member of the drug class of statin s, used for lowering cholesterol hypolipidemic agent in those with hypercholesterolemia and so preventing cardiovascular disease . Lovastatin ... pmid7614366 . Lovastatin also goes by the trade name of Mevacor Merck & Co. in the United States Cite ... of 3 hydroxy 3 methylglutaryl coenzyme A reductase lovastatin. journal Exp Mycol. volume 19 issue 1 ... pmc 1761143 doi 10.1186 1749 8546 1 4 url ref Medical uses The primary uses of lovastatin is for the treatment ... cholesterol levels. ref name AHFS cite web title Lovastatin url http www.drugs.com monograph ... mushroom, naturally contains up to 2.8 lovastatin on a dry weight basis. ref name pmid12622228 ... Z Naturforsch C date 2003 Jan Feb volume 58 issue 1 2 pmid 12622228 pages 62 4 ref Compactin and lovastatin ... investigations of lovastatin, a polyketide derived natural product isolated from Aspergillus terreus ... observed, with very few adverse effects. After the additional animal safety studies with lovastatin .... Large scale trials confirmed the effectiveness of lovastatin. Observed tolerability continued to be excellent, and lovastatin was approved by the US Food and Drug Administration FDA in 1987. ref ... 3 pages 125 30 pmid 15531285 doi 10.1016 j.atherosclerosissup.2004.08.033 ref Lovastatin at its ... this is rare and may occur with the use of any HMG CoA reductase inhibitor. Lovastatin is also naturally ... of dietary supplements derived from red yeast rice , which naturally contains lovastatin, arguing .... Mechanism of action Lovastatin is an inhibitor of 3 hydroxy 3methylglutaryl coenzyme A reductase ... Alberts98 cite journal author Alberts AW title Discovery, biochemistry and biology of lovastatin journal ... and lovastatin interferes with its production by acting as a reversible competitive inhibitor for HMG ... more details
Drugbox verifiedrevid 441338096 image Niacinstr.png image2 Lovastatin.png Combo data type combo component1 Niacin class1 Vitamin component2 Lovastatin class2 Statin Clinical data tradename pregnancy AU A B1 B2 B3 C D X pregnancy US X pregnancy category legal AU Unscheduled S2 S3 S4 S5 S6 S7 S8 S9 legal CA Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL P POM CD Class A, B, C legal US Rx only legal status routes of administration Oral Identifiers CAS number ATC prefix C10 ATC suffix BA01 PubChem DrugBank Ref drugbankcite correct drugbank DrugBank Chemical data Niacin lovastatin trade names Advicor , Mevacor is a drug combination used for the treatment of dyslipidemia . It is a combination of the vitamin niacin and the statin drug lovastatin . The combination preparation is marketed by Abbott Laboratories It was approved by the FDA on December 17, 2001. Dosage The combination is available as tablets containing . ref cite web url http www.rxlist.com cgi generic advicor ids.htm title Advicor package insert, How Supplied section accessdate 2008 03 15 format work ref 500 mg 20 mg 750 mg 20 mg 1000 mg 20 mg 1000 mg 40 mg References Reflist External links http www.advicor.com Advicor website Statins cardiovascular drug stub Category Hypolipidemic agents Category Combination drugs ... more details
enzyme Name lovastatin nonaketide synthase EC number 2.3.1.161 CAS number 235426 97 8 IUBMB EC number 2 3 1 161 GO code 0050637 image width caption In enzymology , lovastatin nonaketide synthase EC number 2.3.1.161 is an enzyme that catalysis catalyzes the chemical reaction acetyl CoA 8 malonyl CoA 11 NADPH 10 H sup sup S adenosyl L methionine math rightleftharpoons math dihydromonacolin L 9 CoA 8 CO sub 2 sub 11 NADP sup sup S adenosyl L homocysteine 6 H sub 2 sub O The 5 substrate biochemistry substrates of this enzyme are acetyl CoA , malonyl CoA , nicotinamide adenine dinucleotide phosphate NADPH , hydrogen ion H sup sup , and S adenosyl L methionine , whereas its 6 product chemistry products are dihydromonacolin L , coenzyme A CoA , carbon dioxide CO sub 2 sub , nicotinamide adenine dinucleotide phosphate NADP sup sup , S adenosyl L homocysteine , and water H sub 2 sub O . This enzyme belongs to the family of transferase s, specifically those acyltransferase s transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl CoA malonyl CoA C acyltransferase decarboxylating, oxoacyl and enoyl reducing, thioester hydrolysing . References reflist 1 cite journal author Heever JP, Hutchinson CR and Vederas JC date 2000 title Lovastatin nonaketide synthase catalyses an intramolecular Diels Alder reaction of a substrate analogue journal J. Am. Chem. Soc. volume 122 pages 11519&ndash 11520 doi 10.1021 ja003216 issue 46 transferase stub Category EC 2.3.1 Category NADPH dependent enzymes Category Enzymes of unknown structure it Lovastatina nonachetide sintasi ... more details
image Ascomycetes.jpg thumb right Cultures of Penicillium and Aspergillus Medicinal molds are molds which were the original source of certain medicines. The most important medicines discovered in molds include the first two statins , penicillin , and griseofulvin . Statins Mevastatin and lovastatin were the first statins discovered. Mevastatin, the first known statin, was found in Penicillium citrinum . Lovastatin, the first commercial statin, was found in Aspergillus terreus . Red yeast rice , made from the fungus Monascus purpureus , contains lovastatin, mevastatin, and monacolin J. Fermentation techniques are used to convert mevastatin to pravastatin . Simvastatin is enzymatically produced from hydrolyzed lovastatin monacolin J . Zaragozic acids Zaragozic acid s, like statins, inhibit cholesterol synthesis, and were originally found in molds. Antibiotics Molds were used to develop penicillin , cephalosporin , fusidic acid , usnic acid , and verticillin A. Antifungals Molds were used to develop the antifungals caspofungin , micafungin , griseofulvin , and anidulafungin . Immunosuppressants Ciclosporin , an immunosuppressant was discovered researching Tolypocladium inflatum . Mycophenolic acid is derived from Penicillium stoloniferum . Potential as a biological source of pharmaceuticals Over two dozen types of endophytic fungi are capable of producing paclitaxel , one of the most important anticancer drugs known. Researchers have reported endophytic fungi that are capable of producing vinblastine , camptothecin , hypericin , and deoxypodophyllotoxin. See also columns list 2 Ant fungus mutualism Aspergillus oryzae k ji fungus used in the production of soy sauce, miso, and sake. Kombucha tea fungus a beverage made from yeast and bacteria. Medicinal mushrooms Mycorrhiza medicinal fungi of the plant kingdom. Penicillium camemberti , Penicillium roqueforti P. roqueforti Saccharomyces boulardii a medicinal yeast. Saccharomyces cerevisiae food products Vegemite , Guinness ... more details
italic title Taxobox name Aspergillus parasiticus regnum Fungi divisio Ascomycota classis Eurotiomycetes ordo Eurotiales familia Trichocomaceae genus Aspergillus species A. terreus binomial Aspergillus terreus binomial authority Charles Thom Thom 1918 ref name Thom1918 cite journal author Thom C, Church MB. title Aspergillus fumigatus , A. nidulans , A. terreus n. sp. and their allies journal American Journal of Botany year 1918 volume 5 issue 2 pages 84 104 ref Aspergillus terreus is a fungus mold commonly used in industry to produce important organic acids, such as itaconic acid and Aconitic acid cis aconitic acid . It was also the initial source for the drug mevinolin lovastatin , a drug for lowering serum cholesterol . A. terreus may cause opportunistic infection in people with deficient immune systems. It is refractory to amphotericin B therapy. ref http www.doctorfungus.org thefungi aspergillus terreus.htm ref Dead link date April 2011 References reflist Category Aspergillus Terreus Eurotiomycetes stub es Aspergillus terreus ... more details
were isolating lovastatin from Aspergillus and monacolins from Monascus , respectively, the latter .... Chemical analysis soon showed that lovastatin and monacolin K are identical. The article The origin ... url ref Lovastatin became the patented, prescription drug Mevacor for Merck & Co ... States and other countries. Lovastatin and other prescription statin drugs inhibit cholesterol synthesis ... K identical to lovastatin . Monacolin content of a red yeast rice product is described in a 2008 ... products that contain monacolin K, i.e., lovastatin, are identical to a drug and, thus, subject to regulation ... lovastatin, do not claim to contain lovastatin, and do not make a claim to lower cholesterol, they are not subject ... effective for lovastatin 20 80 mg dy . In 2006, Liu et al. published a meta analysis of clinical ... with purified lovastatin. One analysis reported several commercial products as being almost ... lovastatin medicinal molds References reflist Further reading cite web author Medicine Net url http ..., Saleem Javed , Mohd. Ali 2010 Optimization of fermentation parameters for higher lovastatin production ... more details
Jonathan A. title Lovastatin and beyond The history of the HMG CoA reductase inhibitors journal Nature ... the product lovastatin mevinolin , which later became known as lovastatin . ref name Tobert ... final.svg thumb right Fig.2 Lovastatin, a type 1 statin Image Fluvastatin.jpg thumb right Fig.3 Fluvastatin ... that belong to this group are ref name Istvan 2001 Lovastatin Figure 2 Pravastatin Simvastatin Type ... 3 Cerivastatin Atorvastatin Rosuvastatin Lovastatin is derived from a fungus source and simvastatin and pravastatin are chemical modifications of lovastatin and as a result do not differ much in structure from lovastatin. ref name Hamelin 1998 All three are partially reduced napthylene ring structures. Simvastatin and lovastatin are inactive lactone s which must be Metabolism metabolized to their active ... 10665838 doi 10.1016 S0163 7258 99 00045 5 issue 3 ref Lovastatin and simvastatin are administered ... is the most predominant isoform involved in metabolism of lovastatin, simvastatin, atorvastatin ... name McTaggart 2003 Atorvastatin 26 60 5 13 17 53 25 45 CYP3A4 98 13 30 No 8 Lovastatin 21 42 2 10 ... more details
Infobox company company name Themis Medicare company logo Image Themis Logo.jpg 220px foundation 1969 location Mumbai , Maharashtra key people Hoshang Sinor small Chairperson small , Dinesh Patel small Managing Director small industry Pharmaceuticals & Drugs revenue 48.752 USD in Millions homepage URL http www.themismedicare.com Background Themis Medicare TML also called Themis Chemical incorporated in 1969, ref http www.richter.hu EN Pages Themis.aspx ref is a manufatcturer of Active Pharmaceutical Ingredients APIs and Formulations. ref http pharmalicensing.com public companies view 3942 themis medicare limited ref It is joint venture with Gedeon Richter, Hungary. Headquartered in Mumbai, the company has four manufacturing facilities located at Vapi Gujarat , Hyderabad Andhra Pradesh , and Haridwar. The company also has presence in 40 countries across the world. TML has an in house R&D facility that focuses on development of new chemical, new processes for production of API and intermediates, fermentation technology and New Drug Delivery Systems. Themis Medicare also sells its research formulations to a variety of Indian pharmaceutical companies. Products Thermis Medicare manufactures APIs that cater to the therapeutic segment such as antituberculosis, antimalarials, cardiology, pain management, anti infectives, haematinics, health and nutrition. Products include Simvastatin, Lovastatin, Propofol, Ethambutol, Di methyl Isosorbide, Artesunate, Lumefenterine, and Arteether. In 2010, the company launched a combination of Lidocaine and Prilocaine in spray form branded as Lovelong for the treatment of premature ejaculation. The company has received the approval from the Drugs Controller of India to manufacture and market the product in India. ref http money.sulekha.com themis medicare launches premature ejaculation spray lovelong news 22695 ref References Reflist Category Pharmaceutical companies of India Category Companies based in Mumbai ... more details
ref The first statin drug available to the general public was lovastatin ... coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation ... more details
coenzyme A reductase lovastatin. journal Exp Mycol. volume 19 issue 1 pages 1 6 publisher ... and lovastatin In vivo research has shown that consumption of oyster mushrooms lowers cholesterol levels ... pmid 19906249 doi 10.1111 j.1753 4887.2009.00230.x ref because these mushrooms naturally contain lovastatin . ref name pmid7614366 Studies have shown they contain up to 2.8 lovastatin on a dry weight ... more details
doi 10.1016 j.bbmt.2007.01.082 ref Lovastatin is an anti cholesterol drug that appears to have ... author Yamada T title Lovastatin does not correct the accumulation of very long chain fatty acids ... first6 I. last7 Kira first7 J. ref A clinical study of lovastatin showed encouraging biochemical changes ... M, Barbosa E, Key LL, Craver JR, Cur JK, Betros R, Singh I title Lovastatin therapy for X linked adrenoleukodystrophy ... blind, placebo controlled crossover trial, researchers found no effect of lovastatin on tissue levels ... cite journal author Engelen M title Lovastatin in X linked adrenoleukodystrophy journal ... and lovastatin. These two new approaches could potentially lower levels of VLCFA in the brain, the therapeutic ... more details
Lescol , lovastatin Mevacor, Altocor, Altoprev , pitavastatin Livalo, Pitava , pravastatin ..., fluvastatin, lovastatin, pravastatin, and simvastatin. ref name Graham2004 cite journal author Graham ..., lovastatin, pravastatin, simvastatin were combined with fibrate fenofibrate or gemfibrozil treatment ..., lovastatin, and simvastatin, but other studies have not found a connection ref name ... needed date August 2010 Lovastatin induces the expression of gene atrogin 1, which is believed to be responsible ... inhibitor of only lovastatin, simvastatin and to a lesser degree atorvastatin and some other medications ... , was interested, and made several trips to Japan starting in 1975. By 1978, Merck had isolated lovastatin ... Image Fluvastatine.png center 150px Lescol, Lescol XL Synthetic CYP2C9 Lovastatin Image Lovastatin.png ... of the 3 Hydroxy 3 methylglutaryl CoA Reductase Inhibitors Lovastatin and Pravastatin in the Liver ... terreus . CYP3A4 Simvastatin Ezetimibe Vytorin Combination therapy Lovastatin Niacin extended ... potency , rosuvastatin, atorvastatin, simvastatin, lovastatin, pravastatin, and fluvastatin. ref ... ostreatus JPG7.jpg thumb right The oyster mushroom , a culinary mushroom, naturally contains lovastatin ... Statin Equivalent Dosages LDL Reduction approx. Atorvastatin Fluvastatin Lovastatin Pravastatin Rosuvastatin ... more details
October 2009 Another medication that affects H Ras is Lovastatin , which is planned as a treatment ... Advisory Board was asked about its use in Costello Syndrome. Research into the effects of Lovastatin ... more details
analysis determined that two of SHP s red yeast rice supplements contained significant amounts of lovastatin ... lovastatin and bear claims about lipid control and other cardiovascular benefits supplied by this ingredient ... more details
, a related oyster mushroom, has been found to contain the cholesterol lowering drug lovastatin ... bodies contain the inhibitor of 3 hydroxy 3 methylglutaryl coenzyme A reductase lovastatin journal ... more details
Year nav topic 1987 science The year 1987 in science and technology involved many significant events, some listed below. Astronomy February 23 Supernova 1987a is observed, the first naked eye supernova since 1604 in science 1604 . 7816 Hanoi Asteroid 7816 Hanoi is discovered by Masahiro Koishikawa . 10500 Nishi koen is discovered. Genetics November 6 Florida rape rapist Tommy Lee Andrews is the first person to be convicted as a result of DNA fingerprinting . ref cite web url http www.txtwriter.com Backgrounders Genetech GEpage14.html title Gene Technology page 14 publisher Txtwriter.com date 1987 11 06 accessdate 2010 04 03 ref Mathematics G del s ontological proof of the existence of God is published posthumously. ref cite book first Kurt last G del year 1995 chapter Ontological Proof title Collected Works Unpublished Essays & Lectures, Volume III pages 388, 403 404 publisher Oxford University Press isbn 0195147227 ref Physics March 18 Woodstock of physics , the marathon session of the American Physical Society s meeting featuring 51 presentations concerning the science of high temperature superconductor s. Medicine March 20 The United States Food and Drug Administration approves anti AIDS drug Zidovudine AZT . ref cite news last Cimons first Marlene title U.S. Approves Sale of AZT to AIDS Patients work Los Angeles Times page 1 date 21 March 1987 ref May The name chronic fatigue syndrome first appears in the medical literature. ref cite journal author Buchwald, Dedra Sullivan, John L. Komaroff, Anthony L. title Frequency of Chronic Active Epstein Barr Virus Infection in a General Medical Practice journal Journal of the American Medical Association volume 257 issue 17 pages 2303 7 year 1987 month May pmid 3033338 doi 10.1001 jama.257.17.2303 url http jama.ama assn.org cgi reprint 257 17 2303 accessdate 2011 07 29 ref May 11 The first heart lung transplant takes place. August 31 The FDA for the first time approves a statin , lovastatin . ref http www.accessdata.fda.g ... more details
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