Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 ICD9 ICD9 273.3 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D008258 Macroglobulinemia is the presence of increased levels of macroglobulin s in the circulating blood . A plasma cell dyscrasia resembling leukemia with cells of lymphocytic, plasmacytic, or intermediate morphology, which secrete an immunoglobulin M monoclonal component. There is diffuse infiltration of bone marrow and also, in many cases, of the spleen, liver, or lymph nodes. The circulating macroglobulin produces symptoms of hyperviscosity syndrome weakness, fatigue, bleeding disorders, and visual disturbances. Peak incidence is in the sixth and seventh decades. Dorland, 28th ed See also Waldenstr m macroglobulinemia Hematopoietic ulcer Immunoproliferative and plasma protein disorders Med stub Category Blood disorders ar sv Makroglobulinemi ... more details
Infobox disease Name Waldenstr m s macroglobulinemia ICD10 ICD10 C 88 0 c 81 ICDO ICDO 9761 3 ICD9 ICD9 ... D008258 Waldenstr m s macroglobulinemia WM, also known as lymphoplasmacytic lymphoma is cancer affecting ... is required, may experience years of symptom free remission . ref International Waldenstrom s Macroglobulinemia Foundation IWMF . Living with Waldenstrom s Macroglobulinemia. ref History and classification ... and treatment of WM. ref name cite pmid 20040909 cite pmid 20040909 ref Causes Waldenstr m s macroglobulinemia ... cite journal author Schop RF title 6q deletion discriminates Waldenstr m macroglobulinemia ... The protein Src gene Src tyrosine kinase is overexpressed in Waldenstr m macroglobulinemia cells ... Waldenstrom macroglobulinemia. Development of diagnostic criteria and identification of prognostic ..., Lopez R, Portero J, Orfao A title Immunophenotypic analysis of Waldenstrom s macroglobulinemia journal ... ref ref name Ghobrial cite journal author Ghobrial IM, Witzig TE title Waldenstrom macroglobulinemia ... A, Treon SP title Diagnosis and management of Waldenstrom s macroglobulinemia journal ... Mediated By The Effects Of IgM From Chapter 88 Waldenstr m Macroglobulinemia Lymphoplasmacytic Lymphoma ... Diagnosis Unreferenced section date January 2011 A diagnosis of Waldenstr m s macroglobulinemia depends ... Institute. http www.cancer.gov cancertopics factsheet Sites Types WM Waldenstr m Macroglobulinemia Questions ..., indicating the extent of Waldenstr m macroglobulinemia related tissue involvement. Rheumatoid factor ... 2 microglobulin and C reactive protein test results are not specific for Waldenstr m macroglobulinemia ... to gamma mobility is highly suggestive of Waldenstr m macroglobulinemia. Immunoelectrophoresis ... with Waldenstr m macroglobulinemia may exhibit more than one M protein. Plasma viscosity must ..., Waldenstrom J, Hasselblom S, Mitelman F title Waldenstrom s macroglobulinemia with the AML MDS associated ... Prognostic Scoring System for Waldenstr m s Macroglobulinemia IPSSWM is a predictive model ... more details
Waldenstr m may refer to Paul Petter Waldenstr m 1838 1917 , Swedish theologian who became the most prominent leader of the free church movement in late 19th century Sweden. Jan G. Waldenstr m 1906 1996 , Swedish physician who identified the condition known as Waldenstr m macroglobulinemia . Grand nephew of Paul Petter Waldenstr m. surname DEFAULTSORT Waldenstrom surname stub ... more details
Orphan date December 2010 In haematology , red cell agglutination is the process whereby red blood cell red cells clump together forming aggregates. This is seen in Waldenstr m s macroglobulinemia , cold agglutinin disease and Infection with Mycoplasma Pneumonia. ref http ashimagebank.hematologylibrary.org cgi content full 2007 0731 7 00010 ref References reflist DEFAULTSORT Red Cell Agglutination Category Hematology ... more details
Image IgM scheme.svg thumb IgM , pictured, is an example of a macroglobulin. Another example is alpha 2 macroglobulin . A macroglobulin is a blood protein plasma globulin of high molecular weight . ref name urlDefinition macroglobulin from Online Medical Dictionary cite web url http cancerweb.ncl.ac.uk cgi bin omd?macroglobulin title Definition macroglobulin from Online Medical Dictionary format work accessdate ref Elevated levels of macroglobulins macroglobulinemia may cause manifestations of excess blood viscosity as is the case for IgM antibodies in Waldenstr m macroglobulinemia and or precipitate within blood vessels when temperature drops as in cryoglobulinaemia . Other macroglobulins include alpha 2 macroglobulin , which is elevated in nephrotic syndrome , diabetes , severe burns, and other conditions, while a deficiency is associated with chronic obstructive pulmonary disease . References reflist External links MeshName Macroglobulins protein stub Globulins Category Blood proteins ... more details
Infobox Disease Name Plasma cell dyscrasia Image Caption DiseasesDB ICD10 ICD10 C 90 c 81 ICD9 ICDO 9730 9739 OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D054219 Plasma cell dyscrasias are cancers of the plasma cell s. Plasma cell dyscrasias are produced as a result of malignant proliferation of a monoclonal population of plasma cells that may or may not secrete detectable levels of a monoclonal immunoglobulin or paraprotein commonly referred to as M protein. Although the most common plasma cell dyscrasia is monoclonal gammopathy of undetermined significance MGUS closely related disorders include multiple myeloma , solitary plasmacytoma of bone, extramedullary plasmacytoma, Waldenstr m s macroglobulinemia WM , primary amyloidosis , light chain deposition disease and heavy chain disease heavy chain disease . The spectrum of MGUS, solitary plasmacytoma of bone, and asymptomatic and symptomatic multiple myeloma may actually represent a natural progression of the same disease. ref http www.accessmedicine.com content.aspx?aid 2794254 ref Classification Cryoglobulinemia Heavy chain disease Monoclonal gammopathy of undetermined significance Multiple myeloma Plasmacytoma Plasma cell leukemia POEMS syndrome AL amyloidosis Primary amyloidosis Immunoglobulin light chain amyloidosis Waldenstr m s macroglobulinemia References reflist Immunoproliferative disorders Hematological malignancy histology Category Hematologic neoplasms medicine stub ... more details
Cryoglobulinemic purpura is a skin condition characterized by purpura and occurring most frequently in multiple myeloma and macroglobulinemia . ref name Andrews cite book author James, William D. Berger, Timothy G. et al. title Andrews Diseases of the Skin clinical Dermatology publisher Saunders Elsevier location year 2006 pages isbn 0 7216 2921 0 oclc doi accessdate ref rp 822 See also Cryoglobulinemia Skin lesion References reflist Cutaneous condition stub Immunoproliferative immunoglobulin disorders Category Vascular related cutaneous conditions ... more details
Hematopoietic ulcers are those occurring with sickle cell anemia , Cooley anemia , congenital hemolytic anemia , polycythemia vera , thrombocytopenic purpura , macroglobulinemia , and cryoglobulinemia . ref name Andrews cite book author James, William D. Berger, Timothy G. et al. title Andrews Diseases of the Skin clinical Dermatology publisher Saunders Elsevier location year 2006 pages isbn 0 7216 2921 0 oclc doi accessdate ref rp 847 See also Skin lesion References reflist Cutaneous condition stub Category Vascular related cutaneous conditions ... more details
Waldenstr m hyperglobulinemic purpura also known as Purpura hyperglobulinemica is a skin condition that presents with episodic showers of petechiae small red or purple spots occurring on all parts of the body, most profusely on the lower extremities. ref name Andrews cite book author James, William D. Berger, Timothy G. et al. title Andrews Diseases of the Skin clinical Dermatology publisher Saunders Elsevier location year 2006 pages isbn 0 7216 2921 0 oclc doi accessdate ref rp 823 ref name Bolognia cite book author Rapini, Ronald P. Bolognia, Jean L. Jorizzo, Joseph L. title Dermatology 2 Volume Set publisher Mosby location St. Louis year 2007 pages 323,329 isbn 1 4160 2999 0 oclc doi accessdate ref See also Waldenstr m s macroglobulinemia Skin lesion References reflist Cutaneous condition stub Category Vascular related cutaneous conditions de Purpura hyperglobulinaemica ... more details
Bing Neel syndrome , first described in 1936, is an extremely rare neurologic complication of Waldenstr m macroglobulinemia WM . It involves central nervous system infiltration by neoplastic lymphoplasmacytoid and plasma cell s with or without cerebrospinal fluid CSF hyperglobulinemia. ref cite journal author Fintelmann F, Forghani R, Schaefer PW, Hochberg EP, Hochberg FH title Bing Neel Syndrome revisited journal Clin Lymphoma Myeloma volume 9 issue 1 pages 104 6 year 2009 month March pmid 19362988 doi 10.3816 CLM.2009.n.028 ref Treatment involves central nervous system penetrating chemotherapy . References Reflist Further reading cite journal author Malkani RG, Tallman M, Gottardi Littell N, et al. title Bing Neel syndrome an illustrative case and a comprehensive review of the published literature journal J. Neurooncol. volume 96 issue 3 pages 301 12 year 2010 month February pmid 19618118 doi 10.1007 s11060 009 9968 3 url Category Syndromes Category Hematologic neoplasms oncology stub ... more details
Heavy legs lang fr jambes lourdes is an alleged medical condition, described as an unpleasant sensation of pain and heaviness in the lower limbs. It is recognised primarily in France , and to a lesser extent elsewhere. Due to the limited recognition it has received, and because of its proliferation in the media and by the alternative health community, many medical practitioners believe it is a sign of hypochondriasis . The cause may be chronic venous insufficiency venous insufficiency ref http www.vanishingveins.com heavy legs.php ref or peripheral arterial disease . ref http www.justanswer.com questions stom causes heavy legs not weight ref Remedies may include drinking plenty of tea , essential oil massages and walking in the sea ref http www.sofeminine.co.uk guide beauty f12844 remedies for heavy legs.html ref or alternatively sleeping with the legs elevated, wearing compression products like compression stockings support stockings and possibly taking diuretics . ref http www.mobilisdirect.com condition 439 heavy legs.aspx ref An underlying condition in a very small minority of cases may be Waldenstr m s macroglobulinemia , a rare disease. ref http www.healthcarerepublic.com rss clinical article 812065 case heavy legs ref It was described by BBC reporter Emma Jane Kirby as a curiously French complaint ... the illness you can only get in health conscious France. ref http news.bbc.co.uk 1 hi programmes from our own correspondent 7779126.stm ref References Reflist Category Ailments of unknown etiology Category Diseases and disorders medical stub fr Jambes lourdes ... more details
TOC right WM Wm , wm , or variants may refer to Companies Wal Mart , an American retailing chain WM, former New York stock exchange ticker symbol for Washington Mutual , a former American savings bank WM, New York stock exchange ticker symbol for Waste Management, Inc , a North American garbage company Science and medicine Waldenstr m s macroglobulinemia , a rare form of blood cancer Working memory , a part of the short term memory White matter , a type of brain tissue Technology and computing Window Maker , a window manager for the X Window System X window manager , a part in the X Window System Windows Media , a multimedia framework for media creation and distribution for Microsoft Windows Windows Messenger , a part included in the Microsoft Windows XP operating system Windows Mobile , an operating system for Pocket PCs Sport WM formation , a formation in association football, so called because it spells out the letters when viewed from above WrestleMania , a professional wrestling pay per view event Military The licence plate code used by the Germany Navy Kriegsmarine in World War II, standing for Wehrmacht Marine Waterloo Medal , a medal awarded to British soldiers who fought in the Waterloo campaign in 1815 Woman Marine, a female member of the United States Marine Corps Transport Weight Measurement, a term used in ship transport clarifyme date April 2012 WHAT DOES THIS ACTUALLY MEAN ?? Western Maryland Railway , a former railway in the United States Windward Islands Airways or Winair IATA airline code Other Wm. also Wm , an abbreviation of the name William Worshipful Master , the head of a lodge in freemasonry disambig Category Initialisms de WM fa WM fr WM ko WM it WM sw WM nl WM ja WM ru WM sv WM ... more details
Infobox disease Name Hyperviscosity syndrome ICD10 ICD9 ICDO Image Caption OMIM MedlinePlus eMedicineSubj emerg eMedicineTopic 756 DiseasesDB 20944 Hyperviscosity syndrome is a group of symptoms triggered by increase in the viscosity of the blood . Symptoms of high blood viscosity include spontaneous bleeding from mucous membrane s, visual disturbances due to retinopathy , and neurologic symptoms ranging from headache and Vertigo medical vertigo to seizures and coma . Hyperviscosity syndrome may be caused by an increase in blood plasma serum proteins or cells. Increased levels of proteins are seen with monoclonal gammopathy monoclonal gammopathies such as Waldenstr m macroglobulinemia and in multiple myeloma particularly IgA and IgG3 . High cell counts are seen in conditions such as polycythemia raised red blood cell s or leukemia more white blood cell s, especially in acute leukemic blast crisis acute leukemic blast crises . Diagnosis Serum viscosity can be measured. Normal is between 1.4 and 1.8 centipoise s but to have symptoms from hyperviscosity, serum viscosity is usually greater than 5 centipoises. Patients will also have evidence of their underlying disorder. Those with myeloma will typically display a rouleaux formation on a peripheral smear and a large globulin gap, indicative of a significant paraprotein load. While viscosity can be directly measured, results can take a few days to return and thus a high index of suspicion is required to make the diagnosis in a timely manner. If hyperviscosity is suspected, treatment may need to be started prior to obtaining the official viscosity level. Treatment Plasmapheresis may be used to decrease viscosity in the case of myeloma, whereas leukapheresis or phlebotomy may be employed in a leukemic or polycythemic crisis, respectively. Blood transfusion s should be used with caution as they can increase serum viscosity. Hydration is a temporizing measure to employ while preparing pheresis. Even after treatment, the cond ... more details
Immunofixation permits the detection and typing of monoclonal antibodies or immunoglobulins in Blood serum serum or urine . It is of great importance for the diagnosis and monitoring of certain blood related diseases such as myeloma . Principle The method detects by precipitation when a soluble antigen Ag is brought in contact with the corresponding antibody , precipitation occurs, which may be visible with the naked eye or microscope. Immunofixation identifies antibodies in a mixture in function of their specific electrophoretic mobility. For the identification antigens are used that are specific for the targeted antibody. Specifically, immunofixation allows the detection of monoclonal antibodies representative of diseases such as myeloma or Waldenstr m macroglobulinemia . Technique Plasma or concentrated urine is deposited on a gel. With an electrical current the proteins are sorted in function of their size, after which antigens for each targeted type of immunoglobulin are deposited on the gel. Thus more or less narrow bands appear on the gel, marking the location of the various immunoglobulines. Immunofixation tends to replace protein electrophoresis because it is faster results within three hours it is somewhat more sensitive. Immunofixation may reveal an immunoglobulin missed out by protein electrophoresis, especially at low concentrations less than 1 gram litre it can be partially automated and can be used in more laboratories it is more easily read and interpreted. Immunofixation is however only sensitive to immunoglobulins and is more expensive than protein electrophoresis. Source fr Immunofixation See also Immunoelectrophoresis External links MedlinePlus 003543 Immunofixation serum MedlinePlus 003593 Immunofixation urine http path.upmc.edu cases case69 serum.html Diagram at University of Pittsburgh School of Medicine immune system Globulins Immune proteins Category Glycoproteins Category Immune system immunology stub fr Immunofixation nl Immunofixatie ... more details
Chembox Verifiedfields changed verifiedrevid 458976997 ImageFile BEZ235.svg ImageSize 200px IUPACName 2 Methyl 2 4 3 methyl 2 oxo 8 quinolin 3 yl 2,3 dihydro 1 H imidazo 4,5 c quinolin 1 yl phenyl propanenitrile OtherNames NVP BEZ235 BEZ 235 Section1 Chembox Identifiers CASNo 915019 65 7 CASNo Ref cascite changed ?? StdInChI Ref stdinchicite correct chemspider StdInChI 1S C30H23N5O c1 30 2,18 31 22 9 11 23 12 10 22 35 28 24 15 19 21 14 20 6 4 5 7 25 20 32 16 21 8 13 26 24 33 17 27 28 34 3 29 35 36 h4 17H,1 3H3 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey JOGKUKXHTYWRGZ UHFFFAOYSA N PubChem 11977753 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 10151099 SMILES N CC c6ccc N5c4c cnc3ccc c1cc2ccccc2nc1 cc34 N C5 O C cc6 C C InChI InChI 1S C30H23N5O c1 30 2,18 31 22 9 11 23 12 10 22 35 28 24 15 19 21 14 20 6 4 5 7 25 20 32 16 21 8 13 26 24 33 17 27 28 34 3 29 35 36 h4 17H,1 3H3 Section2 Chembox Properties C 30 H 23 N 5 O 1 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition BEZ235 or NVP BEZ235 is an imidazoquinoline derivative and PI3K inhibitor ref cite web url http mct.aacrjournals.org content 8 8 2204.abstract title NVP BEZ235, a novel dual phosphatidylinositol 3 kinase mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas ref being investigated as a possible cancer treatment. ref name Maira2009 cite web url http www.biochemsoctrans.org bst 037 0265 0370265.pdf title PI3K inhibitors for cancer treatment where do we stand? year 2009 author Maira et al. doi 10.1042 BST0370265 ref It has been shown to be toxic to Waldenstr m s macroglobulinemia cells. ref Cite pmid 21317453 ref It was the first PI3K inhibitor to enter clinical trials, in 2006 primary outcome results due in 2010 . ref cite web url http clinicaltrials.gov ct2 show NCT00620594 title A Phase I II Study of BEZ235 in Patients With Advanced Solid Malignancies Enriched by Patien ... more details
Infobox Disease Name Paraproteinemia Image Caption DiseasesDB 9614 ICD10 ICD9 ICD9 273.1 ICD9 273.2 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D010265 Paraproteinemia , or monoclonal gammopathy , is the presence of excessive amounts of a single monoclonal gammaglobulin in this case denominated paraprotein in the blood . It denotes an underlying immunoproliferative disorder . It is sometimes considered equivalent to plasma cell dyscrasia . ref DorlandsDict six 000078543 paraproteinemia ref Types Paraproteinemias may be categorized according to the type of monoclonal protein found in blood Light chain s only also known as AL amyloidosis or light chain disease . Heavy chain s only also known as heavy chain disease Whole immunoglobulin s albeit often with an abnormal light heavy chain ratio . The three types of paraproteins may occur alone or in combination in a given individual. Note that while most heavy chains or whole immunoglobulins remain within blood vessels, light chains frequently escape and are excreted by the kidneys into urine, where they take the name of Bence Jones protein . It is also possible for paraproteins usually whole immunoglobulins to form polymer s by aggregating with each other this takes the name of macroglobulinemia and may lead to further complications. For example, certain macroglobulins tend to precipitate within blood vessel with cold, a phenomenon known as cryoglobulinemia . Others may make blood too viscous to flow smoothly usually with IgM macroglobulins , a phenomenon known as Waldenstr m macroglobulinemia . Possible causes Leukemia s and lymphoma s of various types, but usually B cell Non Hodgkin lymphoma s with a plasma cell component. Myeloma Plasmacytoma Lymphoplasmacytic lymphoma Idiopathic no discernible cause some of these will be revealed as leukemias or lymphomas over the years. Monoclonal gammopathy of undetermined significance Primary AL amyloidosis light chains only Diagnosis These disorders are characterized ... more details
citations missing date October 2007 Jan G sta Waldenstr m 17 April 1906 1 December 1996 was a Swedish doctor of internal medicine , who first described the disease which bears his name, Waldenstr m s macroglobulinemia . He was born in Stockholm , and arose from a medical family his father, Johann Henning Waldenstr m 1877 1972 was a professor of orthopedic surgery in Stockholm, and his grandfather, Johan Anton Waldenstr m 1839 1879 was professor of internal medicine in Uppsala. Waldenstr m obtained his M.D. degree at the University of Uppsala , and studied organic chemistry with Hans Fischer at the Technical University of Munich . He was professor of theoretical medicine at the University of Uppsala in 1941, and became professor of practical medicine at the University of Lund in 1944. He was the head of the Department of Medicine at Malm General Hospital until his retirement in 1972. Waldenstr m first described, in 1944, patients suffering from a disease that has subsequently been named for him, Waldenstrom s macroglobulinema , a hyperviscosity syndrome in which symptoms are caused by abnormal lymphocytes which prevent normal bone marrow function, causing anemia and hepatosplenomegaly, and which secrete large immunoglobulins, causing bleeding difficulties. Waldenstr m s other clinical investigations included studies on the various porphyria s, on the benign hypergammaglobulinemic purpura of Waldenstr m, on chonic active hepatitis, pulmonary hemosidersosis, on Bruton s hypogammaglobulinemia, paraneoplastic phenomena , and on carcinoid syndrome . He originated the concept of classification of gammopathies as monoclonal gammopahies vs. polyclonal gammopathies in 1961. He was a member of the National Academy of Science in the United States, the French Academy of Sciences , and was an honorary member of the Royal Society of Medicine , London. Publications J. Waldenstr m Studien ber Porphyrie , Dissertation. Acta Medica Scandinavica , Stockholm, 1937 supplement 82 1 254. ... more details
About a drug IDEC disambiguation IDEC Drugbox Verifiedfields changed verifiedrevid 470611840 image Monoclonal antibody data type mab mab type mab source zu o target CD40L CD40 ligand Clinical data tradename pregnancy AU pregnancy US pregnancy category legal AU legal CA legal UK legal US legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID NA CAS number Ref cascite changed ?? CAS number 252662 47 8 ATC prefix none ATC suffix PubChem DrugBank Ref drugbankcite correct drugbank DrugBank KEGG Ref keggcite correct kegg KEGG D06193 Chemical data chemical formula molecular weight 148,426 Daltons Toralizumab IDEC 131 was a humanized monoclonal antibody and an immunosuppressive drug . Possible indications included treatment of antibody mediated disorders immune thrombocytopenic purpura , lupus nephritis , rheumatoid arthritis , T cell mediated diseases multiple sclerosis , Crohn s disease , and Organ transplantation transplantation s such as solid organ transplantation, pancreatic islet cell transplantation, and cornea l transplantation , and B cell malignancies such as Chronic lymphocytic leukemia CLL small lymphocytic lymphoma , follicular cell lymphoma grade I or II, marginal zone lymphoma , mantle cell lymphoma , MALT lymphoma , Waldenstrom s macroglobulinemia , monocytoid B cell lymphoma relapsed refractory Hodgkin s disease . ref http www.ama assn.org ama1 pub upload mm 365 toralizumab.doc Statement On A Nonproprietary Name Adopted By The USAN Council Toralizumab , American Medical Association . ref In Phase II clinical trial s regarding multiple sclerosis and Crohn s disease, thromboembolism s occurred in at least three patients. A causal connection could not be proven, but since the same adverse effects were seen in trials with a similar antibody hu5C8 , the trials were halted. ref cite book last Luebke first Robert ... more details
italictitle Infobox Journal title Clinical Lymphoma, Myeloma & Leukemia cover Image with unknown copyright status removed Image Clin Lymphoma & Myeloma Cover Shot.jpg formernames Clinical Lymphoma & Myeloma discipline Oncology abbreviation Clin. Lymphoma Myeloma Leuk. publisher CIG Media Group country United States impact 1.596 impact year 2008 frequency Bimonthly editor Bruce D. Cheson, Jorge E. Cort s, Sundar Jagannath history 2000 present website http www.cigjournals.com journals clm.cfm link1 http cigjournals.metapress.com content 121025 link1 name Online access ISSN 2152 2650 eISSN 2152 2669 LCCN 2009207906 OCLC 475038833 RSS http cigjournals.metapress.com content 121025?sortorder asc&export rss Clinical Lymphoma, Myeloma & Leukemia is a Peer review peer reviewed medical journal published by CIG Media Group Cancer Information Group . It was published as Clinical Lymphoma through June 2005, when it changed its name to Clinical Lymphoma & Myeloma . It obtained its current name in January 2010 to reflect new additions to its scope. The journal publishes articles on detection, diagnosis, prevention, and treatment of lymphoma , myeloma , leukemia , and related disorders including macroglobulinemia , amyloidosis , and plasma cell dyscrasia s. ref http www.cancerinformationgroup.com pressPage.cfm?pageId 9 ref The main emphasis is on recent scientific developments in all areas related to lymphoma, myeloma and leukemia. Specific areas of interest include clinical research and mechanistic approaches, drug sensitivity and resistance, gene and antisense therapy, pathology, markers, and prognostic indicators, chemoprevention strategies, multimodality therapy, and integration of various approaches. Abstracting and indexing The journal is indexed on Index Medicus Pubmed , EMBASE Excerpta Medica, Current Contents Clinical Medicine, CINAHL Cumulative Index to Nursing and Allied Health Literature , Chemical Abstracts , and Journal Citation Reports . Article types The journal pub ... more details
Hodgkin s Lymphoma, Primary Central Nervous System M Macroglobulinemia , Waldenstr m Malignant ... macroglobulinemia Wilms tumor kidney cancer , childhood References http www.cancer.gov cancertopics ... more details
File Henry Bence Jones2.jpg thumb Henry Bence Jones File Henry Bence Jones.jpg thumb Henry Bence Jones, painting George Richmond Henry Bence Jones 31 December 1813 20 April 1873 was an England English physician and chemist . Biography He was born at Thorington Hall, Yoxley, Suffolk , the son of Lieutenant Colonel William Jones, an officer in the 5th Dragoon Guards , and Matilda Bence. He went to school at Hingham, Norfolk and a private school in Putney. ref cite journal url http www.bloodmed.com home hann2pdf bjh2962.pdf title HENRY BENCE JONES PHYSICIAN, CHEMIST, SCIENTIST AND BIOGRAPHER A MAN FOR ALL SEASONS journal British Journal of Haematology accessdate 24 September 2010 ref He entered Harrow School Harrow in 1827 and then went up to Trinity College, Cambridge in 1832, obtaining his degree in 1836. ref Venn id JNS831HB name Jones nowiki post Bence Jones nowiki , Henry Bence ref He initially worked for an apothecary but subsequently 1838 enrolled to study medicine at St George s Hospital , and in 1839 chemistry at University College, London . In 1841 he went to University of Giessen Giessen in Germany to work at chemistry with Justus von Liebig Liebig . On his return he took a post at St George s hospital and after being promoted to assistant physician was elected in 1846 to full physician, resigning on health grounds in 1862. In 1847, he described the Bence Jones protein , a globulin protein found in blood and urine, suggestive of multiple myeloma or Waldenstr m s macroglobulinemia . Besides becoming a fellow, and afterwards senior censor, of the Royal College of Physicians , and a fellow of the Royal Society , he held the post of secretary to the Royal Institution for many years. He delivered the Croonian Lecture to the Royal College of Physicians on Matter and Force in 1868. He wrote, in addition to several scientific books and a number of papers in scientific periodicals, The Life and Letters of Faraday 1870 . He died in London on 20 April 1873 and was buri ... more details
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