cytology.jpg thumb right Melanin pigment dark granular material center of image in a pigmented melanoma . Pap stain . Melanin IPAc en audio melanin pronunciation.ogg m l n n lang el ... of the few groups in which it has not been detected . In animals melanin pigments are derivatives of the amino acid tyrosine . The most common form of biological tissue biological melanin is eumelanin ... form of melanin is pheomelanin , a cysteine containing red brown polymer of benzothiazine units largely responsible for red hair and freckles. The presence of melanin in the archaea and bacteria kingdoms is an issue of ongoing debate among researchers in the field. The increased production of melanin in human skin is called melanogenesis . Production of melanin is stimulated by DNA damage induced .... ref http www.bodyrays.com tips.html tanning tips ref The photochemical properties of melanin make it an excellent ... 39 issue 3 title The importance of the fact that melanin is black year 1973 month June author McGinness ... issue 5 title The function of melanin year 1986 month May author Proctor PH, McGinness JE journal ... 1 title The function of melanin or six blind people examine an elephant year 1992 month January author ... conversion chemistry internal conversion . This property enables melanin to dissipate more than ... melanocytes produce little or no melanin. This albino girl is from Papua New Guinea . In humans, melanin is the primary determinant of human skin color skin color . It is also found in hair , the pigmented ... stria vascularis of the inner ear . In the brain, tissues with melanin include the adrenal medulla ... , such as the locus coeruleus and the substantia nigra . The melanin in the skin is produced ... expression express the melanin producing gene s, thereby conferring a greater or lesser concentration of skin melanin. Some individual animals and humans have very little or no melanin in their bodies, a condition known as albinism . Because melanin is an aggregate of smaller component molecules ... more details
medalist stub Russia wintersport bio stub Biathlon bio stub da Vladimir Melanin de Wladimir Michailowitsch Melanin et Vladimir Melanin fr Vladimir Melanine nl Vladimir Melanin no Vladimir Melanjin pl W adimir Melanin ru , fi Vladimir Melanin sv Vladimir Melanin ... more details
Melanin theory is a pseudoscientific , racist theory ref name The New Politics of Race Globalism, Difference, Justice cite web url http books.google.com books?id NybqY0TiKNAC&pg PA48&lpg PA48&dq melanin ...&ved 0CCEQ6AEwADgK v onepage&q melanin 20theory 20is 20racist&f false author Howard Winant ... in the distortion of the known physical properties of melanin , a natural polymer and organic semiconductor ... History ref In humans, melanin is the primary determinant of skin color. People whose ancestors lived ... of eumelanin in their skins. Melanin theorists assert that the possession of greater quantities of melanin ... by assigning dubious properties to melanin based on pseudoscience and distortions of scientific fact or speculation. Scientists consider melanin theory pseudoscience it has no credibility in mainstream medicine or science. ref Skeptinq, Ortiz de Montellano, B. R. 1993. Afrocentricity, Melanin, and Pseudoscience ... 0 doi 10.1111 j.1749 6632.1996.tb23174.x ref Science and the melanin theory Extrapolating from known scientific properties of melanin, adherents of melanin theory claim the substance bestows upon people of color superhuman abilities, ref name sankofach http www.sankofa.ch texts Melanin.htm Melanin in MAD Writer Productions. undated. ref with some contending that melanin is a superconductor . ref ... Cannot Operate Without Black Melanin undated. ref It is, in fact, a semiconductor . ref name nat ... 56.html Other Astounding Properties of Melanin undated. ref that it can process information without ... of neuronal impulses, higher levels of melanin in skin enable nerve synapses to fire more quickly ..., no direct correlation between skin color and the level of melanin in the substantia nigra has been observed. ref name Skeptinq Ortiz De Montellano, Bernard. http www.csicop.org si show magic melanin spreading scientific illiteracy among minorities Magic Melanin Spreading Scientific Illiteracy ... melanin and the substantia nigra vis a vis Parkinson s disease, a neurological disease condition ... more details
File Indole 5 6 quinone.png thumb right Chemical structure of indole 5,6 quinone Catechol melanins are plant melanin s ref Melanins from DOPA containing plants. R.S. Andrews,and J.B. Pridham, Phytochemistry, Volume 6, Issue 1, January 1967, Pages 13 18, doi 10.1016 0031 9422 67 85002 7 ref . They yield catechol on alkali fusion ref http science.jrank.org pages 26549 catechol melanin.html Catechol melanin on science.jrank.org ref . This type of substance can be found in fungi like Ustilago ref Ustilago melanin, a naturally occurring catechol melanin. M. Piattelli, E. Fattorusso, S. Magno and R. A. Nicolaus, Tetrahedron Letters, Volume 4, Issue 15, 1963, Pages 997 998, doi 10.1016 S0040 4039 01 90760 9 ref . Indole 5,6 quinone is a chemical compound found in the oxidative Enzymatic browning browning reaction of fruits like bananas mediated by polyphenol oxidase from tyrosine and catecholamines leading to the formation of catechol melanins. ref http www.agri.gov.il download files QuansahLydia2009MSc 1.pdf Molecular Basis of Catecholamine Biosynthesis in Banana Fruit. Thesis submitted to the R.H. Smith Faculty of Agriculture, Food and Environment Quality Sciences of the Hebrew University of Jerusalem for the degree of Master of Science in Agriculture by Lydia Quansah, March 2009 ref References reflist Category Polyphenols polyphenol stub ... more details
protein Name melanin concentrating hormone receptor 1 caption image width HGNCid 4479 Symbol MCHR1 AltSymbols GPR24 EntrezGene 2847 OMIM 601751 RefSeq NM 005297 UniProt Q99705 PDB ECnumber Chromosome 22 Arm q Band 13.3 LocusSupplementaryData protein Name melanin concentrating hormone receptor 2 caption image width HGNCid 20867 Symbol MCHR2 AltSymbols GPR145 EntrezGene 84539 OMIM 606111 RefSeq NM 032503 UniProt Q969V1 PDB ECnumber Chromosome 6 Arm q Band 16 LocusSupplementaryData Two Melanin concentrating hormone receptors MCHR have recently been characterized MCH R1 and MCH R2. These two receptors share approximately 38 homology biology homology . Melanin concentrating hormone receptor 1 MCH R1 is expressed in all mammals . Melanin concentrating hormone receptor 2 MCH R2 is only found in some primates and carnivores including dogs , ferrets and Human man . Clinical significance Antagonists might be useful in the treatment of obesity ref name pmid16821761 cite journal author Handlon AL, Zhou H title Melanin concentrating hormone 1 receptor antagonists for the treatment of obesity journal ... ref name pmid17655875 cite journal author Luthin DR title Anti obesity effects of small molecule melanin ... . ref name pmid16999451 cite journal author Shimazaki T, Yoshimizu T, Chaki S title Melanin ... cite journal author Saito Y, Maruyama K title Identification of melanin concentrating hormone ... journal author McBriar MD title Recent advances in the discovery of melanin concentrating hormone receptor ... 508 year 2006 pmid 16889232 doi issn ref References Reflist See also Melanin concentrating hormone Melanin External links cite web url http www.iuphar db.org GPCR ChapterMenuForward?chapterID 1339 title Melanin Concentrating Hormone Receptors accessdate author authorlink coauthors date format work ... Pharmacology pages language archiveurl archivedate quote MeshName melanin concentrating hormone receptor ... transmembranereceptor stub Category G protein coupled receptors sr Melanin koncentriraju i ... more details
Infobox protein Name Melanin concentrating hormone caption image width HGNCid 9109 Symbol PMCH AltSymbols EntrezGene 5367 OMIM 176795 RefSeq NM 002674 UniProt P20382 PDB ECnumber Chromosome 12 Arm q Band 23.2 LocusSupplementaryData Melanin concentrating hormone MCH is a cyclic 19 amino acid orexinogenic hypothalamus hypothalamic peptide originally isolated from the pituitary gland of teleost fish where it controls skin pigmentation. In mammals it is involved in the regulation of feeding behavior, mood and energy balance. MCH expressing neurons are located within the lateral hypothalamus and zona incerta. Despite this restricted distribution MCH neurons project widely throughout the brain. MCH knockout mice are hypophagic eat less and are lean. When administered centrally it increases food intake and weight gain. See also Melanin concentrating hormone receptor MCHR References Reflist Unreferenced date November 2011 External links MeshName Melanin concentrating hormone Hormones Neuropeptidergics Category Peptides es Hormona concentradora de melanina gl Hormona concentradora da melanina sr Melanin koncentriraju i hormon ... more details
PBB geneid 84539 Melanin concentrating hormone receptor 2 MCH sub 2 sub also known as G protein coupled receptor 145 GPR145 is a protein that in humans is encoded by the MCHR2 gene . ref name entrez cite web title Entrez Gene MCHR2 melanin concentrating hormone receptor 2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 84539 accessdate ref ref name pmid11355873 cite journal author Mori M, Harada M, Terao Y, Sugo T, Watanabe T, Shimomura Y, Abe M, Shintani Y, Onda H, Nishimura O, Fujino M title Cloning of a novel G protein coupled receptor, SLT, a subtype of the melanin concentrating hormone receptor journal Biochem. Biophys. Res. Commun. volume 283 issue 5 pages 1013 8 year 2001 month May pmid 11355873 doi 10.1006 bbrc.2001.4893 ref ref name pmid11274220 cite ... with Melanin concentrating hormone MCH resulted in upregulation of IDH3A , PCK1 and PFKFB4 and the downregulation ... by melanin concentrating hormone and melanin concentrating hormone receptor 2 interaction journal ... 1249019 ref See also Melanin concentrating hormone receptor References reflist External links cite web url http www.iuphar db.org GPCR ReceptorDisplayForward?receptorID 2999 title Melanin Concentrating ... of a second melanin concentrating hormone receptor, MCH 2R. journal Proc. Natl. Acad. Sci. U.S.A. ... author An S, Cutler G, Zhao JJ, et al. title Identification and characterization of a melanin ..., O Neill K, et al. title Identification and pharmacological characterization of a novel human melanin ... DL, et al. title Short segment of human melanin concentrating hormone that is sufficient for full activation of human melanin concentrating hormone receptors 1 and 2. journal Biochemistry volume ... potency peptide agonist of human melanin concentrating hormone action at human melanin concentrating ... of the melanin concentrating hormone receptors insights from molecular simulations. journal Proteins ... stub Category G protein coupled receptors Category Human proteins sr Melanin koncentriraju i ... more details
PBB geneid 2847 Melanin concentrating hormone receptor 1 , also known as MCH sub 1 sub , is one of the human melanin concentrating hormone receptor s. ref name entrez cite web title Entrez Gene MCHR1 melanin ... plasma membrane protein which binds Melanin concentrating hormone melanin concentrating hormone . The encoded ... pmid17655875 cite journal author Luthin DR title Anti obesity effects of small molecule melanin concentrating ... A title Melanin concentrating hormone receptor 1 antagonists a new perspective for the pharmacologic ... name pmid12885269 cite journal author Hervieu G title Melanin concentrating hormone functions in the nervous ... pmid16999451 cite journal author Shimazaki T, Yoshimizu T, Chaki S title Melanin concentrating hormone ... pmid16548771 cite journal author Hervieu GJ title Further insights into the neurobiology of melanin ..., McKinzie DL, Nomikos GG, Gehlert DR title Melanin concentrating hormone 1 receptor modulates neuroendocrine ... A study of the involvement of melanin concentrating hormone receptor 1 MCHR1 in murine models of depression ..., Nagasaki H title The melanin concentrating hormone system and its physiological functions journal ... 3 ref Selective Ligands Agonists Melanin concentrating hormone MCH S 36057 modified MCH 6 13 fragment ... 125I S36057 a new and highly potent radioligand for the melanin concentrating hormone receptor journal ... of melanin concentrating hormone receptor 1 in rat brain and evidence that sleep parameters are not altered ... H, Thomsen W, Tran TA, Semple G, Sekiguchi Y title ATC0175 an orally active melanin concentrating ..., Li X, Ardayfio P, Craft L, Coskun T, Zhang HY, Chen Y, Witkin JM title Preclinical evaluation of melanin ... cite journal author Doggrell SA title Does the melanin concentrating hormone antagonist SNAP 7941 ... title T 226296 a novel, orally active and selective melanin concentrating hormone receptor antagonist ... 11909603 doi 10.1016 S0014 2999 02 01314 6 url ref See also Melanin concentrating hormone receptor ...?receptorID 2998 title Melanin Concentrating Hormone Receptors MCH sub 1 sub accessdate author authorlink ... more details
This word has several meanings Used as a name A family surname The name of a band, see Cyclefly Hueman and Mako Cyclefly See also Melanin theory hue man dab ... more details
melanin and increased melanin mediated rates of electron transfer measured as reduction of ferricyanide by NADH 3 to 4 fold compared with unexposed cells. ref name Dadachova Similar effects on melanin ..., some non melanized fungi that had been mutated in the melanin pathway grew faster than their melanized counterparts. Limited uptake of nutrients due to the melanin molecules in the fungal cell wall or toxic intermediates formed in melanin biosynthesis have been suggested to contribute to this phenomenon. r Dadachova It is consistent with the observation that despite being capable of producing melanin, many fungi do not synthesize melanin constitutively i.e., all the time , but often only in response ... processes in the suggested melanin based synthesis of organic compounds or other metabolite s for fungal ... ref name Dadachova cite journal title Ionizing radiation changes the electronic properties of melanin ... more details
Orphan date February 2009 SIAscopy measures the amount of haemoglobin , melanin and collagen in the stratum corneum , Epidermis skin epidermis and dermis to a depth of 2 mm, and identifies whether melanin is present in the epidermis or the dermis. The information is presented as SIAscans, which show how these components vary over the skin. SIAscopy makes use of the way light interacts with skin the way it scatters or bounces and the amount absorbed by cells and other structures and how this varies for different wavelengths or colours of light and is based on Symon Cotton s Thesis PhD thesis . ref Cotton S. D 1998 A non invasive Medical imaging imaging system for assisting in the diagnosis of Melanoma malignant melanoma . PhD thesis. University of Birmingham Birmingham University , UK ref ref M. MONCRIEFF,S. COTTON, E. CLARIDGE AND P. HALL 2002 Spectrophotometric intracutaneous analysis a new technique for imaging pigmented skin lesions, British Journal of Dermatology 2002 146 448 457. ref Due to the multi layered structure of the skin, and because the most prominent chromophores have slowly varying spectral properties, it is possible to generate models which can predict the method of light transport within skin. This allows analysis of the skin using broadband Spectrophotometry spectrophotometric techniques. The device used to capture the information is a SIAscope. In order to generate the model, simulations are run for hundreds of thousands of different combinations of haemoglobin, melanin, collagen and dermal melanin. The result of each simulation represents how the camera would respond if it was to image the corresponding combination of skin chromophore s. This information is stored, and then interrogated during each scan in order to generate SIAscans. Each SIAscan is a bitmap representing the concentration of each chromophore on every pixel. Image siaa.JPG thumb ..., melanin, dermal melanin,blood and collagen The example SIAscan shows a melanoma with a series of views ... more details
Dematiaceous is a term to denote dark colored. It is generally used to refer to a group of fungi , the Dematiaceous molds, that produce melanin in their cell walls ref http pathology.ucsf.edu education residency fung morph fungal site dematpage.html ref . The melanin is responsible for the characteristic brown color of the fungal colonies when grown on agar. Dematiaceous fungi show septated hyphae with irregular branching. They are responsible for a number of human infections, including Chromoblastomycosis and Phaeohyphomycosis . ref name Andrews cite book author James, William D. Berger, Timothy G. et al. title Andrews Diseases of the Skin clinical Dermatology publisher Saunders Elsevier location year 2006 pages isbn 0 7216 2921 0 oclc doi accessdate ref References reflist Category Dermatologic terminology ... more details
orphan date June 2008 Gum depigmentation aka gum bleaching is a procedure used in cosmetic dentistry to remove black spots or patches on the gums caused by excessive melanin. The normal color of the gum tissue gingiva is pink, but excess deposits of melanin melanin gingival hyperpigmentation can create what seem to be black spots or patches on the gums, creating an aesthetic or cosmetic problem. Discolouration may also be caused by long term use of certain medications. A clinical assessment is carried out to customize the treatment to the patients needs, and the procedure itself can involve surgical, chemical, or laser ablation techniques. Laser Gum Depigmentation Techniques Laser Gum Bleaching br Melanocytes are cells which reside in the basal layer of the gingival epithelium. These cells produce melanin, which are pigments that cause discoloration or dark spots in gums. A dental laser can target and ablate the melanocytes, thus reducing the production of melanin in the gingival tissue. Following laser depigmentation, the gingiva heals by secondary intention. This results in a lighter and more uniform color of the gums. ref 1 1 An example of laser gum depigmentation treatment. ref 2 2 File Gum depig before.jpg File Gum depig after.jpg References cite journal last Azzeh first Manal M. title Treatment of Gingival Hyperpigmentation by Erbium Doped Yttrium, Aluminum, and Garnet Laser for Esthetic Purposes journal Journal of Periodontology volume 78 issue 1 pages 177 184 date January 2007 doi 10.1902 jop.2007.060167 pmid 17199556 cite journal last Farnoosh first Dr. Alex title Treatment of gingival pigmentation and discoloration for esthetic purposes journal International Journal of Periodontics & Restorative Dentistry volume 1990 issue 10 pages 312 319 date 1990 1. note 1 http www.nylaserperiodontist.com Laser Periodontics.html Part1 Laser Gum Depigmentation 2. note 2 http www.nydentalspecialists.com laserperiodontalplasticsurgery.php lasergumdepigmentation Category De ... more details
Expert subject medicine date November 2008 Smoker s melanosis is characterized by flat, irregular hyperpigmentation of the connective tissue underlying the oral mucosa resulting from tobacco smoking . Basal cells and macrophages in the underlying connective tissue contain unusual amounts of melanin, which creates the darker pigmentation. Macrophages are unable to degrade all of the melanin, a phenomenon known as melanin incontinence . ref JP Sapp, LR Eversole, GP Wysocki. Contemporary Oral and Maxillofacial Pathology. Chapter 6 Epithelial Disorders. Published by Mosby, St. Louis, MO, 1997. ref Incidence Prevalence A study in Sweden showed that 21.5 of smokers and 3 of nonsmokers had lesions that could be classified as smoker s melanosis. ref http www.emedicine.com derm topic655.htm E medicine Smoker s melanosis. Accessed October 5, 2007 ref Causes Smoking is the cause in most cases, although similar hyperpigmentations can sometimes be seen in nonsmokers. Similar hyperpigmentations can be due to physiological pigmentation, amalgam Tattoo Traumatic tattoos tattoo , suntan, drug related melasma , Addison s Disease also known as primary adrenal insufficiency , or Post inflammatory hyperpigmentation. Treatment and Prognosis The lesion usually disappears if the patient stops smoking. If it does not disappear, however, a biopsy can be used to verify the diagnosis. Smoker s melanosis is benign and does not develop into cancer. See also Melanosis coli Peutz Jeghers syndrome References Reflist 2 Category Oral pathology Category Smoking ... more details
Infobox Disease Name Melanosis Image Caption DiseasesDB ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D008548 Melanosis is a form of hyperpigmentation associated with increased melanin . ref MeshName Melanosis ref It can can refer to Melanism Ocular melanosis Smoker s melanosis Oral melanosis See also List of cutaneous conditions References reflist Pigmentation disorders Category Dermatologic terminology dermatology stub ... more details
wiktionary freckles Freckle s are clusters of concentrated melanin which are most often visible on people with a fair complexion. Freckles may also refer to Freckles novel Freckles novel , a 1904 American novel Freckles film , a 1960 American film based on the novel Freckles Brown 1921 1987 , American bull rider Freckles and His Friends , a comic strip published in the US from the 1910s to the late 1970s Freckles is a song by Natasha Bedingfield from her album Pocketful of Sunshine Candies decorated with Nonpareils disambiguation ... more details
A melanomorph is a Chemical substance substance related to the pigment melanin . Melanomorphs originate from the aromatic amino acids tyrosine , tryptophan , and phenylalanine . They tend to absorb ultraviolet B light, with peaks around 280 nanometers . See also Beer s Law . References http www.textbookslist.com sciences organic chemistry 5th edition paula y bruice.html Organic Chemistry 5th Ed. Bruice http www.textbookslist.com sciences organic chemistry 5th edition paula y bruice.html Category Biochemistry ... more details
than 0.1 of the excited melanin molecules will undergo harmful chemical reactions or produce free radicals. Artificial melanin The cosmetic industry claims that the UV filter acts as a artificial melanin . But those artificial substances used in sunscreen s do not efficiently dissipate the energy ... reactions. see Benzophenone . This discrepancy between melanin and sunscreen ingredients is one ... natural melanin 99.9 0.1 2 phenylbenzimidazole 5 sulfonic acid PBSA, Eusolex 232, Parsol HS, 2 ethylhexyl ... more details
, anxiolytic and anorectic effects of a melanin concentrating hormone 1 receptor antagonist journal ... nm741 url ref ref name pmid12783607 cite journal author Doggrell SA title Does the melanin concentrating ... of efficacy of melanin concentrating hormone 1 receptor antagonists in models of depression and anxiety ... and SAR investigations for novel melanin concentrating hormone 1 receptor MCH1 antagonists Part 1 ..., Kong R, Wetzel JM, Andersen K, Marzabadi MR title Synthesis and SAR investigations for novel melanin ..., Gobert A, Panayi F, Rivet JM, Dekeyne A, Brocco M, Ortuno JC, Di Cara B title The melanin concentrating ... The role of melanin concentrating hormone 1 receptors in the voiding reflex in rats journal The Journal ... more details
Infobox Disease Name Hyperpigmentation Image Caption DiseasesDB 24638 ICD10 L81.0 L81.4 ICD9 ICD9 709.0 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D017495 In dermatology , hyperpigmentation is the darkening of an area of skin or nail anatomy nails caused by increased melanin . Causes Hyperpigmentation may be caused by sun damage, inflammation , or other skin injuries, including those related to acne vulgaris . ref cite web url http www.aocd.org skin dermatologic diseases hyperpigmentation.html title Hyperpigmentation publisher American Osteopathic College of Dermatology work Dermatalogic Disease Database accessdate 2006 03 08 ref People with darker Asian, Mediterranean, or African skin tones are also more prone to hyperpigmentation, especially if they have excess sun exposure. Many forms of hyperpigmentation are caused by an excess production of melanin . Hyperpigmentation can be diffuse or focal, affecting such areas as the face and the back of the hands. Melanin is produced by melanocytes at the lower layer of the epidermis. Melanin is a class of pigment responsible for producing color in the body in places such as the eyes, skin, and hair. As the body ages, melanocyte distribution becomes less diffuse and its regulation less controlled by the body. UV light stimulates melanocyte activity, and where concentrations of the cells are denser than surrounding areas, hyperpigmentation is effected. ref http www.kaviskin.com info hyperpigmentation.html Hyperpigmentation Age Spots Hyperpigmentation, Chloasma & Melasma , KAVI. ref Can also be caused by using skin lightening lotions. Hyperpigmentation is associated with a number of diseases or conditions, including Addison s disease and other sources of adrenal insufficiency , in which hormones that stimulate melanin synthesis, such as melanocyte stimulating hormone MSH , are frequently elevated. Cushing s disease or other excessive adrenocorticotropic hormone ACTH production, because MSH production is a bypro ... more details
volume 23 issue 2 pages 261 275 pmid 5476812 doi 10.1016 0012 1606 70 90098 9 ref Melanin is a pigment ... date January 2009 Through a process called melanogenesis , these cells produce melanin , which is a pigment ... existing melanin. There are both basal and activated levels of melanogenesis in general, lighter ... of the melanin is dark and it absorbs all the UVB light and it blocks it from passing the skin layer ... Dubious date January 2009 . Tyrosinase is required for melanocytes to produce melanin from ..., or the production of melanin by cultured melanocytes, although the method by which it works ... of melanin is also initiated by ACTH an adrenocorticotropic hormone . Citation needed date September 2011 Once made, melanin is moved along arm like structures called Dendrite non neuronal dendrites ... biology vesicles or packages of the chemical inside a plasma membrane . The melanin is in organelles ... more details
Drugbox verifiedrevid 434884863 IUPAC name 6 4 chlorophenyl 3 3 methoxy 4 2 pyrrolidin 1 ylethoxy phenyl 3 H thieno 3,2 d pyrimidin 4 one image GW 803,430 structure.png Clinical data tradename pregnancy category legal status routes of administration Pharmacokinetic data bioavailability metabolism elimination half life excretion Identifiers CAS number ATC prefix none ATC suffix PubChem Chemical data C 25 H 24 Cl 1 N 3 O 3 S 1 molecular weight 481.993 g mol smiles C5CCCN5CCOc3ccc cc3OC n1cnc2cc sc2c1 O c cc4 ccc4Cl GW 803,430 GW 3430 is a drug used in scientific research and is a binding selectivity selective non peptide Antagonist pharmacology antagonist at the melanin concentrating hormone Receptor biochemistry receptor Melanin concentrating hormone receptor 1 MCH sub 1 sub . In animal studies it has anxiolytic , antidepressant and anorectic effects. ref Chaki S, Kanuma K. Neuropeptide receptors Novel therapeutic targets for depression and anxiety disorders. Drugs of the Future . 2007 32 9 809. ref ref name pmid19182070 cite journal author Gehlert DR, Rasmussen K, Shaw J, Li X, Ardayfio P, Craft L, Coskun T, Zhang HY, Chen Y, Witkin JM title Preclinical evaluation of melanin concentrating hormone receptor 1 antagonism for the treatment of obesity and depression journal The Journal of Pharmacology and Experimental Therapeutics volume 329 issue 2 pages 429 38 year 2009 month May pmid 19182070 doi 10.1124 jpet.108.143362 url ref References Reflist 2 Antidepressants Anxiolytics Anorectics Neuropeptidergics Category Antidepressants Category Anxiolytics Category Anorectics Category Pyrrolidines Category Phenol ethers Category Lactams Category Organochlorides gastrointestinal drug stub nervous system drug stub sr GW 803,430 ... more details
The Agouti gene is responsible for determining whether a mammal s coat is banded agouti or of a solid color non agouti . ref Silver, Lee Mouse Genetics ref The chief product of the Agouti gene is Agouti signalling peptide ASP , but there are a number of alternative splice products. In dog s, the Agouti gene is associated with various Coat dog Patterns coat colors and patterns , including sable and tan points. ref http homepage.usask.ca schmutz alleles.html Dog Coat Color Genetics, December 27, 2008, Sheila Schmutz ref In horse s, the Agouti gene suppresses the action of the Melanocortin 1 receptor extension locus that produces black horse black pigment Melanin Eumelanin eumelanin into point coloration on the mane, tail, lower legs and tips of the ears, thus allowing the underlying red pigment, Melanin Pheomelanin pheomelanin , to appear on the body. This produces the color known as bay horse bay . Mice that are heterozygous for the Agouti yellow allele have yellow coats and tendencies towards obesity. Mice that are homozygous for the Agouti yellow allele have the lethal gene . Mice that are homozygous for the non agouti allele and non agouti yellow allele have non agouti coat color such as black . References references Category Peptides Category Peptide hormones gene 20 stub de Agouti ... more details
Refimprove auto yes date December 2009 Infobox disease Name Hypopigmentation Image Vitiligo03.jpg Caption Hypopigmentation in vitiligo. DiseasesDB 21207 ICD10 L80, L81.5 L81.6 ICD9 ICD9 709.0 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D017496 Hypopigmentation is the loss of skin color. It is caused by melanocyte or melanin depletion, or a decrease in the amino acid tyrosine , which is used by melanocytes to make melanin. Treatments Oftentimes, hypopigmentation can be brought on by laser treatments however, the hypopigmentation can be treated with other lasers or light sources. ref Reszko A, Sukal S, Geronemus R. Reversal of Laser Induced Hypopigmentation with a Narrow Band UVB Light Source in a Patient with Skin Type VI . Dermatol Surg. 34 1 4. 2008 ref Associated conditions It is seen in albinism idiopathic guttate hypomelanosis leprosy leucism Phenylketonuria pityriasis alba vitiligo Angelman syndrome tinea versicolor See also Hyperpigmentation References Reflist Pigmentation disorders Category Dermatologic terminology Category Disturbances of human pigmentation Disease stub ar de Hypopigmentierung fr Hypopigmentation hi om Hypopigmentation ... more details
Infobox Anatomy Name PAGENAME Latin pars intermedia adenohypophyseos GraySubject 275 GrayPage 1275 Image Gray1181.png Caption Median sagittal through the hypophysis of an adult monkey. Pars intermedia labeled at bottom center. Image2 Caption2 Precursor System Artery Vein Nerve Lymph MeshName MeshNumber DorlandsPre p 07 DorlandsSuf 12616939 Code TerminologiaHistologica 3 08 02.2.00007 Pars intermedia is the boundary between the anterior and posterior lobes of the pituitary . It contains three types of cells Anterior pituitary basophil basophil s, chromophobe s, and colloid filled cyst s. The cysts are the remainder of Rathke s pouch . In human fetus fetal life, this area produces melanocyte stimulating hormone or MSH which causes the release of melanin pigment in skin melanocytes pigment cells . However, the pars intermedia is normally either very small or entirely absent in adulthood. In lower vertebrates fish, amphibians MSH from the pars intermedia is responsible for darkening of the skin, often in response to changes in background color. This color change is due to MSH stimulating the dispersion of melanin pigment in dermal skin melanophore cells. External links BUHistology 14001loa BUHistology 14101loa OklahomaHistology 38 11 UIUCHistologySubject 991 pituitary gland Category Endocrine system bn de Hypophysenzwischenlappen es Hip fisis media nl Pars intermedia ... more details
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