to double strand breaks requires the Mre11Rad50Xrs2 complex journal Nat. Cell Biol. volume ... Human Rad50 is physically associated with human Mre11 identification of a conserved multiprotein ... and DNA repair factors Rad50, Mre11, and p95 journal J. Biol. Chem. volume 273 issue 34 pages ... JH, de Lange T title Cell cycle regulated association of RAD50MRE11 NBS1 with TRF2 and human telomeres ... Rad50 is physically associated with human Mre11 identification of a conserved multiprotein complex ... activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95 journal ... cleavage by the Mre11Rad50 complex journal Genes Dev. volume 13 issue 10 pages 1276 88 year ... Song first9 Mei hua cite journal author Zhu XD title Cell cycle regulated association of RAD50MRE11 ... M title Human Rad50Mre11 is a flexible complex that can tether DNA ends journal Mol. Cell volume ...For the computer character encoding RADIX 50 PBB geneid 10111 DNA repair protein RAD50 , also known as RAD50 , is a protein that in humans is encoded by the RAD50 gene . ref name entrez cite web title Entrez Gene RAD50RAD50 homolog S. cerevisiae url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ... similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA repair Double strand breaks DNA double strand break repair. This protein forms a complex with MRE11A MRE11 and Nibrin NBS1 . The protein ... encode distinct proteins, have been reported. ref name entrez Interactions Rad50 has been shown to Protein ... CC, Chen PL, Lee WH title RINT 1, a novel Rad50 interacting protein, participates in radiation induced ... author Goedecke W, Eijpe M, Offenberg HH, van Aalderen M, Heyting C title Mre11 and Ku70 interact ... Mre11 binding, focus formation, and nuclear localization journal Mol. Cell. Biol. volume 21 issue 6 ... M, Petrini JH title The Mre11 complex and the metabolism of chromosome breaks the importance of communicating ... cloning and characterization of splice variants of human RAD50 gene journal Gene volume 235 issue 1 ... more details
Rad50 may refer to RADIX 50 , a character encoding scheme in computing RAD50 gene , in biology, encodes a DNA repair protein involved in DNA double strand break DSB repair Letter NumberCombDisambig ... more details
The MRX complex is a heterotrimeric protein complex consisting of MRE11A Mre11 , Rad50 , and Xrs2 . It is a budding yeast homolog of the mammalian Mre11Rad50 Nbs1 Mre11Rad50 Nbs1 MRN DNA damage repair complex. protein stub Category Protein complexes ko MRX ... more details
year 1996 month Sep. title Human Rad50 is physically associated with human Mre11 identification of a conserved ... and DNA repair factors Rad50, Mre11, and p95 journal J. Biol. Chem. volume 273 issue 34 pages ... Jul. title Cell cycle regulated association of RAD50MRE11 NBS1 with TRF2 and human telomeres journal ... P title Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11 .... title Cell cycle regulated association of RAD50MRE11 NBS1 with TRF2 and human telomeres. journal ... and interaction architecture of the DNA double strand break repair Mre11 nuclease and Rad50 ... JR, Weaver DT title Isolation and characterization of the human MRE11 homologue journal Genomics ... with the RAD50 homolog this complex is required for nonhomologous joining of DNA ends and possesses ... cite web title Entrez Gene MRE11A MRE11 meiotic recombination 11 homolog A S. cerevisiae url http ..., Heyting C year 1999 month Oct. title Mre11 and Ku70 interact in somatic cells, but are differentially ... format accessdate laysummary laysource laydate quote ref Rad50 , ref name pmid10508516 ref name ... Akira, Shinohara Miki year 2008 month May. title Forkhead associated domain of yeast Xrs2, a homolog ... Mar. title Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear ... author Dolganov GM, Maser RS, Novikov A, et al. title Human Rad50 is physically associated with human Mre11 identification of a conserved multiprotein complex implicated in recombinational DNA repair ... to complement yeast mre11 defects due to species specific protein interactions. journal Gene volume ... Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis. journal ... MRE11 in cancer. journal Cancer Res. volume 61 issue 1 pages 23 6 year 2001 pmid 11196167 doi Cite ... mediate Mre11 binding, focus formation, and nuclear localization. journal Mol. Cell. Biol. volume ... stub es MRE11A ja Mre11 ... more details
Spo11 is a protein used in a complex along with Mre11 and RAD50 gene Rad50 during meiotic genetic recombination recombination . ref name pmid20364103 cite journal author Inagaki A, Schoenmakers S, Baarends WM title DNA double strand break repair, chromosome synapsis and transcriptional silencing in meiosis journal Epigenetics Official Journal of the DNA Methylation Society volume 5 issue 4 pages year 2010 month May pmid 20364103 doi url http www.landesbioscience.com journals epi abstract.php?id 11518 issn ref It is also involved in the creation of double stranded breaks in the DNA in the early stages of this process. Its active site contains a tyrosine which ligates and dissociates with DNA to promote break formation. One Spo11 protein is involved per strand of DNA, thus two Spo11 proteins are involved in each double stranded break event. Genetic exchange between two DNA molecules by homologous recombination begins with a break in both strands of DNA called a double strand break and recombination is started by an endonuclease enzyme that cuts the DNA molecule that receives the exchanged DNA. In meiosis the enzyme is SPO11, which is related to DNA topoisomerase s. Topoisomerases change DNA by transiently breaking one or both strands, passing the unbroken DNA strand or strands through the break and repairing the break the broken ends of the DNA are covalently linked to topoisomerase. SPO11 is similarly attached to the DNA when it forms double strand breaks during meiosis. ref name isbn0 7637 7992 X cite book author authorlink editor others title Lewin s Genes X edition 10 language publisher Jones and Bartlett Publishers, Inc location year 2011 origyear pages 353 354 quote isbn 0 7637 7992 X oclc doi url accessdate ref References Reflist colwidth 30em Category Proteins protein stub ja Spo11 ... more details
SPO may refer to tocright Technology SPO Microsoft SharePoint Online, Microsoft Cloud Computing, Office 365. See Microsoft Online Services Economics Secondary market offering Secondary Public Offering , an equity capital market instrument Strong Pareto optimum , a concept in economics when no further improvements can be made Linguistics Subject, Predicate, Object indicating the predominant word order in a natural language Places Sankt Peter Ording , a resort town in Germany Sciences pour l oenologie, a French INRA research center on Montpellier La Gaillarde campus Miscellaneous SPO , aka Matthew A. Spolar SPO , a Lithuanian sports magazine SPO Rouen Basket , a basketball club in Rouen, France Scholarly Publishing Office of the University of Michigan University Library Serbian Renewal Movement a monarchist political party Socialist Party of Ontario a minor political party in the Canadian Province of Ontario Service and Parts Operations, in the automotive industry Strengthening Participatory Organization , a rights based organization in Pakistan System Program Office, in the U.S. Department of Defense .spo, a file extension used in the SPSS statistics software Supreme Prosecutors Office of the Republic of Korea is a South Korean prosecutor organization Similar to SPO is SP The Social Democratic Party of Austria , or in lang de Sozialdemokratische Partei sterreichs Spo11 , a protein used in a complex along with Mre11 and Rad50 during meiotic recombination disambig cs SPO de SPO eo SPO it SPO ... more details
The MRN complex is heterotrimeric protein complex consisting of MRE11A Mre11 , Rad50 and Nbs1 . It is involved in DNA repair in mammals. Nbs1 is referred to as Nibrin . ref cite web url http atlasgeneticsoncology.org Genes NBS1ID160.html title Atlas of Genetics and Cytogenetics in Oncology and Haematology NBS1 accessdate 2008 02 12 ref This complex recognizes DNA damage and rapidly relocates to DSB sites and forms nuclear foci. Its activity includes end processing of both physiological and mutagenic DNA double strand breaks DSBs . ref name eMed cite web url http www.emedicine.com DERM topic725.htm title eMedicine Nijmegen Breakage Syndrome accessdate 2008 02 12 ref . It appears that as part of its end processing of DSBs, short single strand oligonucleotides are produced, which induce activation of Ataxia telangiectasia mutated Ataxia Telangiectasia Mutated ATM , ref cite journal title Mre11Rad50 Nbs1 dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity journal The EMBO Journal authors Jazayeri A, Balestrini A, Garner E, Haber JE, Costanzo V volume 27 issue 14 pages 1953 1962 year 2008 PMID 18596698 doi 10.1038 emboj.2008.128 url http www.nature.com emboj journal v27 n14 pdf emboj2008128a.pdf ref ultimately leading to activation of the DNA damage checkpoint. References reflist protein stub Category Protein complexes ... more details
Aug. title Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11 ... J H, de Lange T year 2000 month Jul. title Cell cycle regulated association of RAD50MRE11 NBS1 with TRF2 ... associated domain of yeast Xrs2, a homolog of human Nbs1, promotes nonhomologous end joining through ... K M, Concannon P year 2001 month Mar. title Distinct functional domains of nibrin mediate Mre11 ... ref Rad50 , ref name pmid10783165 ref name pmid12679336 ref name pmid9705271 ref name ... more details
Function A trimeric complex of the three proteins Mre11 , RAD50 gene RAD50 and NBS1 Xrs2 in yeast , called the Mre11Rad50 Nbs1 MRN complex in humans, recruits ATM to double strand breaks ... and Ser1893 is required for normal activity of the ATM kinase. Activation of ATM by the Mre11Rad50 ..., such as Mre11 and MDC1 , acquire post translational modifications which are generated by the sensor ... of DNA damage checkpoint protein 1 MDC1 which binds to MRE11 , and the subsequent stimulation ... mutations in the ATM gene ATM . Most other AT like disorders are defective in genes encoding the Mre11Rad50 Nbs1 MRN protein complex. One feature of the ATM protein is its rapid increase in kinase ... more details
of protein s, which participate in the following steps End binding and tethering In yeast, the Mre11Rad50Xrs2Mre11Rad50Xrs2 MRX complex is recruited to DSBs early and is thought to promote bridging ... of Dnl4 catalyzed DNA end joining by the Rad50Mre11Xrs2 and Hdf1 Hdf2 complexes. 2001 Mol. Cell 8, 1105 1115. PMID 11741545 ref The corresponding mammalian complex of Mre11Rad50 Nbs1 Mre11Rad50 Nbs1 ... Mre11 roles in DNA repair beyond homologous recombination journal Nat. Struct. Mol. Biol. volume ... with Yku80 and the Xrs2 FHA domain journal Genetics volume 180 issue 4 pages 1809 19 year 2008 month ... end joining and V D J recombination. 2002 Cell 108, 781 794. PMID 11955432 ref Mre11 has ... more details
PBB geneid 8295 Transformation transcription domain associated protein , also known as TRRAP , is a protein that in humans is encoded by the TRRAP gene . ref name pmid9708738 cite journal author McMahon SB, Van Buskirk HA, Dugan KA, Copeland TD, Cole MD title The novel ATM related protein TRRAP is an essential cofactor for the c Myc and E2F oncoproteins journal Cell volume 94 issue 3 pages 363 74 date August 1998 pmid 9708738 doi 10.1016 S0092 8674 00 81479 8 url ref ref name pmid9885574 cite journal author Vassilev A, Yamauchi J, Kotani T, Prives C, Avantaggiati ML, Qin J, Nakatani Y title The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily journal Mol. Cell volume 2 issue 6 pages 869 75 date December 1998 pmid 9885574 doi 10.1016 S1097 2765 00 80301 9 url ref TRRAP belongs to the phosphatidylinositol 3 kinase related kinase protein family. Function TRRAP is an adapter protein , which is found in various multiprotein chromatin complexes with histone acetyltransferase activity HAT , which in turn is responsible for epigenetic Transcription genetics transcription activation. TRRAP a central role in MYC c Myc transcription activation, and also participates in cell transformation by MYC. It is required for p53 TP53 , E2F1 , and E2F4 mediated transcription activation. It is also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. ref name pmid17694078 cite journal author Murr R, Vaissi re T, Sawan C, Shukla V, Herceg Z title Orchestration of chromatin based processes mind the TRRAP journal Oncogene volume 26 issue 37 pages 5358 72 date August 2007 pmid 17694078 doi 10.1038 sj.onc.1210605 url ref TRRAP is also required for the cell cycle checkpoint mitotic checkpoint and normal cell cycle progression. The Mre11 Rad50 Nbs1 MRN complex composed of MRE11A MRE11 , RAD50 gene RAD50 , and Nibrin NBS1 is involved in the detection and repair of DNA DNA repair Do ... more details
protein expressed by the Rad50 hRad50 gene. This complex, known as the Mre11Rad50 Nbs1 MRN complex ... ATM, the Mre11Rad50 Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje ... whether or not ATLD carries an increased risk to develop cancer. Because those mutations of Mre11 that severely impair the MRE11 protein are incompatible with life, individuals with ATLD all have some partial function of the Mre11 protein, and hence likely all have their own levels of disease severity ... of DNA double strand breaks. MRE11A Mre11 and Nbs1 are also targets for phosphorylation by the Ataxia ... identify abnormality of the proteins of potentially responsible genes, such as ATM, MRE11, nibrin, TDP1 ..., and RAD50. Radiation Exposure People with A T have an increased sensitivity to ionizing radiation ... more details
Orphan date February 2009 PBB geneid 60561 RAD50 interacting protein 1 is a protein that in humans is encoded by the RINT1 gene . ref name pmid11096100 cite journal author Xiao J, Liu CC, Chen PL, Lee WH title RINT 1, a novel Rad50 interacting protein, participates in radiation induced G 2 M checkpoint control journal J Biol Chem volume 276 issue 9 pages 6105 11 year 2001 month Mar pmid 11096100 pmc doi 10.1074 jbc.M008893200 ref ref name pmid15029241 cite journal author Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M title Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi journal EMBO J volume 23 issue 6 pages 1267 78 year 2004 month Mar pmid 15029241 pmc 381410 doi 10.1038 sj.emboj.7600135 ref ref name entrez cite web title Entrez Gene RINT1 RAD50 interactor 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 60561 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions RINT1 has been shown to Protein protein interaction interact with Rad50 ref name pmid11096100 cite journal last Xiao first J authorlink coauthors Liu C C, Chen P L, Lee W H year 2001 month Mar. title RINT 1, a novel Rad50 interacting protein, participates in radiation induced G 2 M checkpoint control journal J. Biol. Chem. volume 276 issue 9 pages 6105 11 publisher location United States issn 0021 9258 pmid 11096100 doi 10.1074 jbc.M008893200 bibcode oclc id url language format accessdate laysummary laysource laydate quote ref and ZW10 . ref name pmid15029241 cite journal last Hirose first Hidenori authorlink coauthors Arasaki Kohei, Dohmae Naoshi, Takio Koji, Hatsuzawa Kiyotaka, Nagahama Masami, Tani Katsuko, Yamamoto Akitsugu, Tohyama Masaya, Tagaya ... related p130 protein controls telomere lengthening through an interaction with a Rad50 interacting ... more details
, Nevanlinna H, Bartek J. Aberrations of the MRE11RAD50 NBS1 DNA damage sensor complex in human breast cancer MRE11 as a candidate familial cancer predisposing gene. Mol Oncol. 2008 Dec 2 4 296 316. ref ... . Orphanet J Rare Dis. 2012 Feb 28 7 13.. ref MRE11 HRR Breast ref Bartkova J, Tommiska J, Oplustilova ... 1 and 2 ATM Ataxia telangiectasia mutated NBS Nijmegen breakage syndrome MRE11 meiotic recombination ... more details
. This ability to bind to DNA contributes to its ability to inhibit the nuclease activity of the Mre11Rad50 Nbs1 MRN complex as well as the nuclease activity of Mre11 alone. ref name Paull2001 ... more details
RADIX 50 , commonly called Rad 50 or RAD50 , is a character encoding created by Digital Equipment Corporation for use on their DECSYSTEM 20 DECsystem , Programmed Data Processor PDP , and VAX computers. RADIX 50 s 40 character repertoire 050 in octal allows up to 3 characters to be encoded and packed into 16 bits PDP 11 , VAX or 6 characters plus flag information into one 36 bit word PDP 6 , PDP 10 DECsystem 10, DECSYSTEM 20 . The actual encoding differed between the 36 bit and 16 bit systems. class wikitable PDP 6, PDP 10 DECsystem 10, DECSYSTEM 20 ref Frank Durda IV. RADIX50 Character Code Reference . 2004. http nemesis.lonestar.org reference telecom codes radix50.html ref style background ccffff rowspan 2 Most br significant br bits colspan 8 Least significant bits width 10 000 width 10 001 width 10 010 width 10 011 width 10 100 width 10 101 width 10 110 width 10 111 style background ccffff 000 style background white space style background eeeeff 0 style background eeeeff 1 style background eeeeff 2 style background eeeeff 3 style background eeeeff 4 style background eeeeff 5 style background eeeeff 6 style background ccffff 001 style background eeeeff 7 style background eeeeff 8 style background eeeeff 9 style background eeffee A style background eeffee B style background eeffee C style background eeffee D style background eeffee E style background ccffff 010 style background eeffee F style background eeffee G style background eeffee H style background eeffee I style background eeffee J style background eeffee K style background eeffee L style background eeffee M style background ccffff 011 style background eeffee N style background eeffee O style background eeffee P style background eeffee Q style background eeffee R style background eeffee S style background eeffee T style background eeffee U style background ccffff 100 style background eeffee V style background eeffee W style background eeffee X style background eeffee Y style background eeffee Z style background ... more details
T year 2000 month Jul. title Cell cycle regulated association of RAD50MRE11 NBS1 with TRF2 and human ... of RAD50MRE11 NBS1 with TRF2 and human telomeres. journal Nat. Genet. volume 25 issue 3 pages ... Rad50 , ref name pmid15100233 ref name pmid10888888 Nibrin ref name pmid10888888 and MRE11A . ref ... more details
2000 month Jul. title Cell cycle regulated association of RAD50MRE11 NBS1 with TRF2 and human ... cite journal author Zhu XD, K ster B, Mann M, et al. title Cell cycle regulated association of RAD50MRE11 NBS1 with TRF2 and human telomeres. journal Nat. Genet. volume 25 issue 3 pages 347 52 year ... more details
observed in Rad50 ref name hopfner cite journal doi 10.1016 S0092 8674 00 80890 9 author Hopfner ... biology of Rad50 ATPase ATP driven conformational control in DNA double strand break repair and the ABC ... more details
Encyclopedia
top
