PBB geneid 4609 Myc c Myc is a regulator gene that Genetic code codes for a transcription factor . A mutated version of Myc is found in many cancers, which causes Myc to be Glossary of gene expression ... Chromosomal translocation translocation involving Myc is t 8 14 which is critical to the development of most cases of Burkitt s Lymphoma . A recent study demonstrated that temporary inhibition of Myc ... AN, Swigart LB, Nasi S, Evan GI title Modelling Myc inhibition as a cancer therapy journal Nature ... In the human genome , Myc is located on Chromosome 8 human chromosome 8 and is believed to regulate ... s HATs . This means that in addition to its role as a classical transcription factor, Myc also ... R, Jin VX, Krig SR, Lemen JM, Wey A, Farnham PJ, Knoepfler PS. title N Myc regulates a widespread ... 10.1158 0008 5472.CAN 08 1961 ref Discovery Myc gene was first discovered in Burkitt s lymphoma patients ... to myelocytomatosis viral oncogene v Myc . Thus, the newfound cellular gene was named c Myc. Structure Myc protein belongs to Myc family of transcription factors, which also includes N Myc and L Myc genes. Myc family of transcription factors contain bHLH LZ basic Helix Loop Helix Leucine Zipper domain. Myc protein, through its bHLH domain can bind to DNA , while the leucine zipper domain allows the dimerization with its partner Max, another bHLH transcription factor. Myc mRNA contains an Internal ... Function Myc protein is a transcription factor that activates expression of a great number of genes .... In addition, myc has a direct role in the control of DNA replication. ref name pmid17597761 cite journal ... J, Dalla Favera R title Non transcriptional control of DNA replication by c Myc journal Nature volume 448 issue 7152 pages 445 51 year 2007 month July pmid 17597761 doi 10.1038 nature05953 ref Myc ... target genes, Myc activation results in numerous biological effects. The first to be discovered ... downregulates Bcl 2 , differentiation and stem cell self renewal. Myc is a very strong Oncogene ... more details
A myc tag is a polypeptide protein tag derived from the c myc gene product that can be added to a protein using recombinant DNA technology. It can be used for affinity chromatography , then used to separate recombinant, overexpressed protein from wild type protein expressed by the host organism. It can also be used in the isolation of protein complexes with multiple subunits. A myc tag can be used in many different assays that require recognition by an antibody . If there is no antibody against the studied protein, adding a myc tag allows one to follow the protein with an antibody against the Myc epitope. Examples are cellular localization studies by immunofluorescence or detection by Western blotting . The peptide sequence of the myc tag is N EQKLISEEDL C 1202 Da . It can be fused to the C terminus and the N terminus of a protein. It is advisable not to fuse the tag directly behind the signal peptide of a secretory protein, since it can interfere with translocation into the secretory pathway . A monoclonal antibody against the myc epitope , named 9E10, is available from the non commercial Developmental Studies Hybridoma Bank ref http dshb.biology.uiowa.edu c myc Developmental Studies Hybridoma Bank 9E10 ref . See also Polyhistidine tag , a different tag used in similar ways References references Category Biochemistry ... more details
PBB geneid 4613 V myc myelocytomatosis viral related oncogene, neuroblastoma derived avian , also known ... of the MYC family of transcription factor s and encodes a protein with a basic helix loop helix basic ... bHLH protein in order to bind DNA. ref cite web title Entrez Gene MYCN v myc myelocytomatosis viral ... C, Brodeur GM title Preferential amplification of the paternal allele of the N myc gene in human neuroblastomas ... 10.1038 ng0693 191 url issn ref Interactions N Myc has been shown to Protein protein interaction interact ... protein that forms a sequence specific DNA binding complex with Myc journal Science journal Science ... Myc journal Oncogene volume 18 issue 15 pages 2489 98 publisher location ENGLAND issn 0950 9232 ... laydate quote ref N Myc is also stabilized by Aurora A which protects it from degradation. ref Stabilization of N Myc Is a Critical Function of Aurora A in Human Neuroblastoma Cancer Cell, Volume ..., Holger Christiansen, Bernd Berwanger, Martin Eilers ref See also Myc References reflist Further ... of the transcription factors of the Myc Max Mad network. journal Gene volume 277 issue 1 2 ... strand opposite to N myc. journal Cell Growth Differ. volume 3 issue 6 pages 385 90 year 1992 ... of the acidic central region of the N myc protein by casein kinase II. journal Eur. J. Biochem ... GW, Armstrong BC, Battey JF title N myc mRNA forms an RNA RNA duplex with endogenous antisense ... a sequence specific DNA binding complex with Myc. journal Science volume 251 issue 4998 pages ... G, Boyd JP, et al. title N myc amplification in multiple homogeneously staining regions in two human ... Sequence of a germ line N myc gene and amplification as a mechanism of activation. journal Oncogene ... JM title Nucleotide sequence of the human N myc gene. journal Proc. Natl. Acad. Sci. U.S.A. volume ... author Michitsch RW, Melera PW title Nucleotide sequence of the 3 exon of the human N myc gene. journal ... of the protein encoded by the human N myc oncogene. journal Science volume 232 issue ... more details
Orphan date December 2007 Automatically added by User SoxBot. If this is an error, please contact User Soxred93 C myc mRNA is a type of Messenger RNA mRNA that serves as a template for the Myc MYC protein which is implicated in the rapid growth of cancer cancer cells . This mRNA is a topic of ongoing research to investigate the viability of preventing cancer growth by cleaving or degrading the c myc mRNA. ref cite journal last Lee first Chow H. authorlink Chow H. Lee coauthors Dan Sparanese title CRD BP shields c myc and MDR 1 RNA from endonucleolytic attack by a mammalian endoribonuclease journal ScienceDirect volume 35 issue 4 pages 1209 1221 date 31 January 2007 doi 10.1093 nar gkl1148 pmid 17264115 pmc 1851641 ref References references Category RNA Category Molecular biology ... more details
PBB geneid 9111 N myc interactor also known as N myc and STAT interactor is a protein that in humans is encoded by the NMI gene . ref name pmid8668343 cite journal author Bao J, Zervos AS title Isolation and characterization of Nmi, a novel partner of Myc proteins journal Oncogene volume 12 issue 10 pages 2171 6 year 1996 month Aug pmid 8668343 pmc doi ref ref name pmid9989503 cite journal author Zhu M, John S, Berg M, Leonard WJ title Functional association of Nmi with Stat5 and Stat1 in IL 2 and IFNgamma mediated signaling journal Cell volume 96 issue 1 pages 121 30 year 1999 month Mar pmid 9989503 pmc doi 10.1016 S0092 8674 00 80965 4 ref ref name entrez cite web title Entrez Gene NMI N myc ... 9111 accessdate ref Function NMYC interactor NMI interacts with N Myc NMYC and Myc CMYC two members of the oncogene Myc family , and other transcription factors containing a bZIP domain Zip , Basic ... RL, Meyerdierks A, Hagemeier M, B ttger EC, Naumovski L title Interferon inducible Myc STAT interacting ... November pmid 10950963 doi 10.1074 jbc.M006975200 url issn ref Myc , ref name pmid11916966 cite journal author Li H, Lee TH, Avraham H title A novel tricomplex of BRCA1, Nmi, and c Myc inhibits c Myc induced human telomerase reverse transcriptase gene hTERT promoter activity in breast cancer journal ... localization of Myc interacting protein Nmi. journal J. Interferon Cytokine Res. volume 18 issue 9 ... RL, Naumovski L title Subcellular localization of interferon inducible Myc stat interacting protein ... Bannasch D, Weis I, Schwab M title Nmi protein interacts with regions that differ between MycN and Myc ... Chen J, Shpall RL, Meyerdierks A, et al. title Interferon inducible Myc STAT interacting protein Nmi ... author Li H, Lee TH, Avraham H title A novel tricomplex of BRCA1, Nmi, and c Myc inhibits c Myc induced ... with the N myc interacting protein Nmi. journal J. Mol. Biol. volume 353 issue 5 pages 1033 42 ... induced apoptosis is enhanced by Myc and involves PKCdelta signaling. journal Int. J. Cancer volume ... more details
Infobox rfam Name c myc internal ribosome entry site IRES image RF00216.jpg width caption Predicted secondary structure and sequence conservation of IRES c myc Symbol IRES c myc AltSymbols c myc IRES Rfam RF00216 miRBase miRBase family RNA type Cis regulatory element Cis reg Internal ribosome entry site IRES Tax domain Eukaryota GO GO 0043022 SO SO 0000243 CAS number EntrezGene HGNCid OMIM PDB RefSeq Chromosome Arm Band LocusSupplementaryData The c myc internal ribosome entry site IRES is an Cis regulatory element RNA element present in the Five prime untranslated region 5 UTR of the mRNA of C myc and allows cap independent translation. The mammalian c myc gene is a proto oncogene which is required for cell proliferation, transformation and death. c myc mRNA has an alternative method of translation via internal ribosome entry where ribosomes are recruited to the IRES located in the 5 UTR thus bypassing the typical eukaryotic cap dependent translation pathway. ref cite journal last Le Quesne first JP coauthors Stoneley M, Fraser GA, Willis AE year 2001 title Derivation of a structural model for the c myc IRES journal J Mol Biol volume 310 pages 111&ndash 126 pmid 11419940 doi 10.1006 jmbi.2001.4745 issue 1 ref References reflist External links Rfam id RF00216 name c myc internal ribosome entry site IRES Category Cis regulatory RNA elements molecular cell biology stub ... more details
Infobox rfam Name n myc internal ribosome entry site IRES image RF00226.jpg width caption Predicted secondary structure and sequence conservation of IRES n myc Symbol IRES n myc AltSymbols n myc IRES Rfam RF00226 miRBase miRBase family RNA type Cis regulatory element Cis reg Internal ribosome entry site IRES Tax domain Eukaryota GO GO 0043022 SO SO 0000243 CAS number EntrezGene HGNCid OMIM PDB RefSeq Chromosome Arm Band LocusSupplementaryData The N myc internal ribosome entry site IRES is an cis regulatory element RNA element found in the n myc gene. The myc family of genes when expressed are known to be involved in the control of cell growth, differentiation and apoptosis. n myc mRNA has an alternative method of translation via an internal ribosome entry site where ribosome s are recruited to the IRES located in the 5 UTR thus bypassing the typical eukaryotic cap dependent translation pathway. ref cite journal last Jopling first CL coauthors Willis AE year 2001 title N myc translation is initiated via an internal ribosome entry segment that displays enhanced activity in neuronal cells journal Oncogene volume 20 pages 2664&ndash 2670 pmid 11420678 doi 10.1038 sj.onc.1204404 issue 21 ref See also Mnt IRES Tobamovirus internal ribosome entry site IRES Tobamovirus IRES TrkB IRES References reflist 1 External links Rfam id RF00226 name n myc internal ribosome entry site IRES Category Cis regulatory RNA elements molecular cell biology stub ... more details
Infobox rfam Name L myc internal ribosome entry site IRES image RF00261.jpg width caption Predicted secondary structure and sequence conservation of IRES L myc Symbol IRES L myc AltSymbols Rfam RF00261 miRBase miRBase family RNA type Cis regulatory element Cis reg Internal ribosome entry site IRES Tax domain Eukaryota GO GO 0043022 SO SO 0000243 CAS number EntrezGene HGNCid OMIM PDB RefSeq Chromosome Arm Band LocusSupplementaryData The L myc internal ribosome entry site IRES is an Cis regulatory element RNA element present in the Five prime untranslated region 5 UTR of the mRNA of L myc that allows cap independent translation. L myc undergoes translation via the internal ribosome entry site and bypasses the typical eukaryotic cap dependent translation pathway 1 . The myc family of genes when expressed are known to be involved in the control of cell growth, differentiation and apoptosis. References reflist 1 1 cite journal last Jopling first CL coauthors Spriggs KA, Mitchell SA, Stoneley M, Willis AE year 2004 title L Myc protein synthesis is initiated by internal ribosome entry journal RNA volume 10 pages 287&ndash 298 pmid 14730027 doi 10.1261 rna.5138804 issue 2 pmc 1370540 External links Rfam id RF00261 name L myc internal ribosome entry site IRES Category Cis regulatory RNA elements molecular cell biology stub ... more details
Mariscal Sucre Airport airport codes MYC SVBS is an airport near Maracay , Venezuela . External links WAD SVBS coord 10.24998 67.64942 type airport region VE D source ourairports.com data display title Category Airports in Venezuela Venezuela airport stub ... more details
Infobox Airport name El Libertador nativename small Base A rea Libertador image IATA MYC ICAO SVBL type Military owner oper Venezuelan Air Force location Maracay , Venezuela elevation f 1,450 elevation m 442 coordinates coord 10 10 50 N 067 33 40 W region VE type airport website metric rwy y r1 number 09 27 r1 length m 3,170 r1 length f 10,400 r1 surface Concrete footnotes Source DAFIF ref name WAD http www.worldaerodata.com wad.cgi?airport SVBL Airport information for SVBL from DAFIF effective October 2006 ref ref name GCM GCM MYC source DAFIF ref El Libertador Air Base lang es Base A rea Libertador airport codes MYC SVBL is a military airport and base for the Venezuelan Air Force . It is located in Maracay , a city in central Venezuela and the capital of the States of Venezuela state of Aragua state Aragua . Facilities The air base resides at an elevation of convert 1450 ft 0 above mean sea level . It has one runway designated 09 27 with a concrete surface measuring convert 3170 x 48 m ft 0 . ref name WAD References references External links NWS current SVBL ASN MYC Category Airports in Venezuela Category Aragua es Base A rea El Libertador ru ... more details
in Nature 2004 , MYC Inactivation Uncovers Pluripotent Differentiation and Tumor Dormancy in Hepatocellular ..., et al. MYC Inactivation Uncovers Pluripotent Differentiation and Tumor Dormancy in Hepatocellular ..., CCIS, Stanford University 2001 2004 Key Scientific Contributions Dr. Shachaf has researched how MYC ... MYC expression kills the tumor. But more importantly, she showed that MYC reprograms the tumor cells. When MYC expression is taken away from the tumor cells, they are released to their inherent ... dormancy and MYC inactivation pushing cancer to the brink of normalcy. Cancer Res. 2005 June 1 65 ... dormancy and MYC inactivation pushing cancer to the brink of normalcy. Cancer Res. 2005 June 1 65 ... of a MYC overexpressing tumor cell following MYC inactivation. Cancer Res. 2008 Jul 1 68 13 5132 42. ref The MYC protein in cancers correlates with poor prognosis and is a difficult therapeutic target. To find alternative downstream targets of MYC, Dr. Shachaf defined levels of MYC expression required to drive tumorigenic properties. She conducted a systematic genomic and proteomic profile of MYC ... by Atorvastatin Prevents and Reverses MYC Induced Tumorigenesis. Equal contributionBlood. 2007 ... SK and Felsher DW. Systematic molecular analysis of a MYC overexpressing tumor cell following MYC ... for the tumor generating activities of the MYC oncogene. This study is an important demonstration ... more details
Infobox rfam Name Mnt IRES image RF00457.jpg width caption Predicted secondary structure and sequence conservation of IRES mnt Symbol IRES mnt AltSymbols Rfam RF00457 miRBase miRBase family RNA type Cis regulatory element Cis reg Internal ribosome entry site IRES Tax domain Eukaryota GO GO 0043022 SO SO 0000243 CAS number EntrezGene HGNCid OMIM PDB RefSeq Chromosome Arm Band LocusSupplementaryData The Mnt internal ribosome entry site Internal ribosome entry site IRES is an cis regulatory element RNA element . Mnt is a transcriptional repressor related to the Myc Mad family of transcription factor s. It is thought that this IRES allows efficient Mnt synthesis when cap dependent translation initiation is reduced. ref cite journal last Stoneley first M coauthors Spencer JP, Wright SC year 2001 title An internal ribosome entry segment in the 5 untranslated region of the mnt gene journal Oncogene volume 20 pages 893&ndash 897 pmid 11314024 doi 10.1038 sj.onc.1204157 issue 7 ref See also N myc internal ribosome entry site IRES N myc IRES Tobamovirus internal ribosome entry site IRES Tobamovirus IRES TrkB IRES References reflist 1 External links Rfam id RF00457 name Mnt IRES Category Cis regulatory RNA elements molecular cell biology stub ... more details
Orphan date April 2012 Fbx15 , otherwise known as Fbxo15 , is a protein expressed in un differentiate cellular differentiate d embryonic stem cell s. It is expressed during coexpression of Oct3 4 , MYC c Myc , Klf4 , and SOX2 , four genes identified to be important in embryonic stem cell self renewal and differentiation repression. ref Takahashi, K., and S. Yamanaka. Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors. Cell 126.4 2006 663 76. Print. ref There is an enhancer site upstream of the Fbx15 encoding transcription gene that contains an octamer like binding motif and a Sox like binding motif. Lacking of Fbx15 leads to normal embryonic development, but it is often used as a downstream identifier to check for stem cell pluripotency and also Oct3 4 activation, as Oct3 4 deactivation leads to a complete lack of Fbx15 expression. References Reflist Category Proteins protein stub ... more details
Refimprove date January 2011 class infobox bordered style width 15em text align left font size 95 style font size larger Manly Yacht Club colspan 2 style text align center Image Myc burgee.png 200px br Burgee Founded 1950 Clubhouse East Esplanade, Manly, NSW, 2095 Country AUS Website http www.myc.org.au Manly Yacht Club MYC is a sailing club in the suburb of Manly, New South Wales Manly on the Northern Beaches Sydney Northern Beaches of Sydney , in the state of New South Wales , Australia . External links http www.myc.org.au Manly Yacht Club http www.manlysailability.com.au Manly Sailability Coord 33.80315 151.2854 format dms type landmark region AU NSW display title Category Yacht clubs in Australia Category Sport in Sydney Category Sports teams in Sydney de Manly Yacht Club ... more details
PBB geneid 26292 C Myc binding protein is a protein that in humans is encoded by the MYCBP gene . ref name pmid9797456 cite journal author Taira T, Maeda J, Onishi T, Kitaura H, Yoshida S, Kato H, Ikeda M, Tamai K, Iguchi Ariga SM, Ariga H title AMY 1, a novel C MYC binding protein that stimulates transcription activity of C MYC journal Genes Cells volume 3 issue 8 pages 549 65 year 1998 month Dec pmid 9797456 pmc doi 10.1046 j.1365 2443.1998.00206.x ref ref name entrez cite web title Entrez Gene MYCBP c myc binding protein url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 26292 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The MYCBP gene encodes a protein that binds to the N terminal region of MYC MIM 190080 and stimulates the activation of E box dependent transcription by MYC. supplied by OMIM ref name entrez cite web title Entrez Gene MYCBP c myc binding protein url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 26292 accessdate ref Interactions MYCBP has been shown to Protein protein interaction interact with AKAP1 , ref name pmid12223483 cite journal last Yukitake first Hiroshi authorlink coauthors .... title AMY 1, a c Myc binding protein, is localized in the mitochondria of sperm by association with S AKAP84 ... ref name pmid12223483 and Myc . ref name pmid9797456 cite journal doi 10.1046 j.1365 2443.1998.00206.x ... M, Tamai K, Iguchi Ariga S M, Ariga H year 1998 month Aug. title AMY 1, a novel C MYC binding protein that stimulates transcription activity of C MYC journal Genes Cells volume 3 issue 8 pages 549 65 ... reading citations cite journal author Furusawa M, Ohnishi T, Taira T, et al. title AMY 1, a c Myc binding ... Ariga SM, et al. title AMY 1 associate of Myc 1 localization to the trans Golgi network through ... cite journal author Sedoris KC, Thomas SD, Miller DM title c myc promoter binding protein regulates ... more details
PBB geneid 4610 L myc 1 proto oncogene protein is a protein that in humans is encoded by the MYCL1 gene . ref name pmid8978772 cite journal author Speleman F, Van Camp G, Van Roy N title Reassignment of MYCL1 ... name entrez cite web title Entrez Gene MYCL1 v myc myelocytomatosis viral oncogene homolog 1, lung ... N, Minna J, Kennett RH title The human L myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines detection by monoclonal antibodies specific to two myc homology box sequences .... title Max a helix loop helix zipper protein that forms a sequence specific DNA binding complex with Myc ... variant of Max on E box vs initiator element mediated regulation by c Myc journal Oncogene volume 18 ... B title Function and regulation of the transcription factors of the Myc Max Mad network journal Gene ... author Ikegaki N, Minna J, Kennett RH title The human L myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines detection by monoclonal antibodies specific to two myc ... 401025 cite journal author Kaye F title Structure and expression of the human L myc gene reveal a complex ... Sausville first8 E last9 Minna first9 J cite journal author De Greve J title The human L myc gene ... F last7 Sausville first7 E last8 Minna first8 J cite journal author DePinho RA title The human myc gene family structure and activity of L myc and an L myc pseudogene journal Genes Dev. volume 1 issue ... journal author Atchley WR, Fitch WM title Myc and Max molecular evolution of a family of proto oncogene ... vs initiator element mediated regulation by c Myc journal Oncogene volume 18 issue 15 pages 2489 ... Kumimoto H title L myc genotype is associated with different susceptibility to lung cancer in smokers ... title L myc restriction fragment length polymorphism and histological pattern of invasion in lung adenocarcinoma ... author Primdahl H title Allelic deletions of Rb and L myc in urine sediments from patients with bladder ... MYC proto oncogene in ovarian carcinomas journal Am. J. Pathol. volume 162 issue 5 pages 1603 10 year ... more details
the boats docked at the MYC basin for fear that the Japanese soldiers might use them to launch ... to liberate Manila . The US Army occupied the Club and in March 1947, MYC was able to secure the property ... more details
PBB geneid 4149 Protein max also known as myc associated factor X is a protein that in humans is encoded ... ref ref name entrez cite web title Entrez Gene MAX MYC associated factor X url http www.ncbi.nlm.nih.gov ... with other family members, which include MXD1 Mad , MXI1 Mxl1 and Myc . Myc is an oncogene ... for some of them is unknown. ref name entrez cite web title Entrez Gene MAX MYC associated factor ... have a repressive function. In contrast, Myc contains a transactivation domain but cannot homodimerize. However Myc can heterodimerize with Max to form heterodimers that can both bind DNA and transactivate. The transcriptionally active Max Myc dimer promotes cell proliferation as well as apoptosis . ref name pmid8193530 cite journal author Amati B, Land H title Myc Max Mad a transcription factor ... 1 ref Interactions MAX gene has been shown to Protein protein interaction interact with Myc , ref name ... cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c Myc journal Mol. Cell. Biol. volume ... TD, Cole MD title The novel ATM related protein TRRAP is an essential cofactor for the c Myc and E2F ... E, Beltran RJ, Yu J, Kalpana GV title c MYC interacts with INI1 hSNF5 and requires the SWI SNF complex ... proteins MLH1 and MSH2 with c MYC and MAX journal Oncogene volume 22 issue 6 pages 819 25 year ... title Mad a heterodimeric partner for Max that antagonizes Myc transcriptional activity journal Cell ... myc journal Oncogene volume 16 issue 9 pages 1149 59 year 1998 month March pmid 9528857 doi 10.1038 ... of Myc Max and Mad Max recognizing DNA. Molecular bases of regulation by proto oncogenic transcription ... variant of Max on E box vs initiator element mediated regulation by c Myc journal Oncogene volume ... , ref name pmid2006410 ref name pmid10229200 N Myc , ref name pmid2006410 cite journal doi 10.1126 ... Max a helix loop helix zipper protein that forms a sequence specific DNA binding complex with Myc ... The Myc Max Mad network and the transcriptional control of cell behavior. journal Annu. Rev. Cell ... more details
Orphan date February 2009 PBB geneid 84864 MYC induced nuclear antigen is a protein that in humans is encoded by the MINA gene . ref name pmid12091391 cite journal author Tsuneoka M, Koda Y, Soejima M, Teye K, Kimura H title A novel myc target gene, mina53, that is involved in cell proliferation journal J Biol Chem volume 277 issue 38 pages 35450 9 year 2002 month Sep pmid 12091391 pmc doi 10.1074 jbc.M204458200 ref ref name entrez cite web title Entrez Gene MINA MYC induced nuclear antigen url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 84864 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Bonaldo MF, Lennon G, Soares MB title Normalization and subtraction two approaches to facilitate gene discovery. journal Genome Res. volume 6 issue 9 pages 791 806 year 1997 pmid 8889548 doi 10.1101 gr.6.9.791 cite journal author Strausberg RL, Feingold EA, Grouse LH, et al. title Generation and initial analysis of more than 15,000 full length human and mouse cDNA sequences journal Proc. Natl. Acad. Sci. U.S.A. volume 99 issue 26 pages 16899 903 year 2003 pmid 12477932 doi 10.1073 pnas.242603899 pmc 139241 cite journal author Teye K, Tsuneoka M, Arima N, et al. title Increased Expression of a Myc Target Gene Mina53 in Human Colon Cancer journal Am. J. Pathol. volume 164 issue 1 pages 205 16 year 2004 pmid 14695334 doi 10.1016 S0002 9440 10 63111 2 pmc 1602225 cite journal author Ota T, Suzuki Y, Nishikawa T, et al. title Complete sequencing and characterization of 21,243 full length human cDNAs journal Nat. Genet. volume 36 issue 1 pages ... Expression of Myc target gene mina53 in subtypes of human lymphoma journal Oncol. Rep. volume 18 issue ... al. title Overexpression of the myc target gene Mina53 in advanced renal cell carcinoma journal Pathol ... more details
orthologs have been shown to have the ability to bind CD44 , b actin, c myc , IGF2 , H19 gene H19 ... c myc gene has been shown in the formation of tumours. ref name Doyle c myc mRNA contains a coding region instability determinant CRD which CRD BP has been shown to bind, therefore, protecting c myc ... more details
Infobox rfam Name Tobamovirus internal ribosome entry site IRES image RF00225.jpg width caption Predicted secondary structure and sequence conservation of IRES Tobamo Symbol IRES Tobamo AltSymbols Tobamo IRES Rfam RF00225 miRBase miRBase family RNA type Cis regulatory element Cis reg Internal ribosome entry site IRES Tax domain Virus es GO GO 0043022 SO SO 0000243 CAS number EntrezGene HGNCid OMIM PDB RefSeq Chromosome Arm Band LocusSupplementaryData The Tobamovirus internal ribosome entry site IRES is an element that allows cap and end independent translation biology translation of mRNA in the host cell. ref cite journal last Ivanov first PA coauthors Karpova OV, Skulachev MV, Tomashevskaya OL, Rodionova NP, Dorokhov YuL, Atabekov JG year 1997 title A tobamovirus genome that contains an internal ribosome entry site functional in vitro journal Virology volume 232 pages 32&ndash 43 pmid 9185586 doi 10.1006 viro.1997.8525 issue 1 ref The internal ribosome entry site IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor , eIF4F. ref cite journal last Kolupaeva first VG coauthors Pestova TV, Hellen CU year 2000 title Ribosomal binding to the internal ribosomal entry site of classical swine fever virus journal RNA volume 6 pages 1791&ndash 1807 pmid 11142379 doi 10.1017 S1355838200000662 issue 12 pmc 1370049 ref See also Mnt IRES N myc internal ribosome entry site IRES N myc IRES TrkB IRES References reflist 1 External links Rfam id RF00225 name Tobamovirus internal ribosome entry site IRES molecular cell biology stub Category Cis regulatory RNA elements ... more details
Infobox rfam Name TrkB IRES image RF00547.jpg width caption Predicted secondary structure and sequence conservation of IRES TrkB Symbol IRES TrkB AltSymbols Rfam RF00547 miRBase miRBase family RNA type Cis regulatory element Cis reg Internal ribosome entry site IRES Tax domain Eukaryota GO GO 0043022 SO SO 0000243 CAS number EntrezGene HGNCid OMIM PDB RefSeq Chromosome Arm Band LocusSupplementaryData The TrkB internal ribosome entry site IRES is an cis regulatory element RNA element which is present in the 5 UTR sequence of the mRNA. TrkB is a neurotrophin receptor which is essential for the development and maintenance of the nervous system. The internal ribosome entry site IRES element allows cap independent translation of TrkB which may be needed for efficient translation in neuronal dendrites. ref cite journal last Dobson first T coauthors Minic A, Nielsen K, Amiott E, Krushel L year 2005 title Internal initiation of translation of the TrkB mRNA is mediated by multiple regions within the 5 leader journal Nucleic Acids Res volume 33 pages 2929&ndash 2941 pmid 15908588 doi 10.1093 nar gki605 issue 9 pmc 1133793 ref See also Mnt IRES N myc internal ribosome entry site IRES N myc IRES Tobamovirus internal ribosome entry site IRES Tobamovirus IRES References reflist 1 External links Rfam id RF00547 name TrkB IRES Category Cis regulatory RNA elements molecular cell biology stub ... more details
Infobox Disease Name Feingold syndrome Image Caption DiseasesDB 33706 ICD10 ICD9 ICDO OMIM 164280 MedlinePlus eMedicineSubj eMedicineTopic MeshID Feingold syndrome also called oculodigitoesophagoduodenal syndrome is a rare autosomal dominant hereditary disorder . It is named after Murray Feingold , an American physician who first described the syndrome in 1975. Until 2003, at least 79 patients have been reported worldwide. ref cite journal author T sz s A, Meijer R, Scheffer H, et al. title Expanding the clinical spectrum of MYCN related Feingold syndrome journal Am. J. Med. Genet. A volume 140 issue 20 pages 2254 6 year 2006 month October pmid 16906565 doi 10.1002 ajmg.a.31407 ref Characteristics Feingold syndrome is marked by various combinations of microcephaly , limb malformations , esophagus esophageal and duodenum duodenal atresia s, and sometimes learning disability or mental retardation . ref cite journal author Celli J, van Bokhoven H, Brunner HG title Feingold syndrome clinical review and genetic mapping journal Am. J. Med. Genet. A volume 122A issue 4 pages 294 300 year 2003 month November pmid 14518066 doi 10.1002 ajmg.a.20471 ref Genetics and cause Image Autosomal dominant en.svg thumb right Feingold Syndrome is inherited in an autosomal dominant fashion. Feingold syndrome is caused by mutations in the N Myc neuroblastoma derived V myc avian myelocytomatosis viral related oncogene MYCN which is located on the short arm of chromosome 2 2p24.1 . Diagnosis and treatment The diagnosis is based on the following clinical findings microcephaly clinodactyly and shortness of index and little fingers syndactyly of 2nd & 3rd and 4th & 5th toe short palpebrae palpebral fissures esophageal and or duodenal atresia References reflist External links http www.ncbi.nlm.nih.gov bookshelf br.fcgi?book gene&part feingold GeneReview NIH UW entry on Feingold syndrome Transcription factor coregulator deficiencies DEFAULTSORT Feingold Syndrome Category Autosomal dominant disord ... more details
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