Orphan date February 2009 PBB geneid 23077 Probable E3 ubiquitin protein ligase MYCBP2 also known as myc binding protein 2 or protein associates with myc PAM is an enzyme that in humans is encoded by the MYCBP2 gene . ref name pmid9689053 cite journal author Guo Q, Xie J, Dang CV, Liu ET, Bishop JM title Identification of a large Myc binding protein that contains RCC1 like repeats journal Proc Natl Acad Sci U S A volume 95 issue 16 pages 9172 7 year 1998 month Sep pmid 9689053 pmc 21311 doi 10.1073 pnas.95.16.9172 ref ref name entrez cite web title Entrez Gene MYCBP2 MYC binding protein 2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 23077 accessdate ref PAM contains a N terminus N terminal leucine zipper , central MycMYC binding, and C terminus C terminal histone binding protein homology domains. ref name pmid9689053 Interactions MYCBP2 has been shown to Protein protein interaction interact with Myc . ref name pmid9689053 References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Nakajima D, Okazaki N, Yamakawa H, et al. title Construction of expression ready cDNA clones for KIAA genes manual curation of 330 KIAA cDNA clones. journal DNA Res. volume 9 issue 3 pages 99 106 year 2003 pmid 12168954 doi 10.1093 dnares 9.3.99 cite journal author Nagase T, Ishikawa K, Suyama M, et al. title Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. journal DNA Res. volume 5 issue 6 pages 355 64 year 1999 pmid 10048485 doi 10.1093 dnares 5.6.355 cite journal author Zhang QH, Ye M, Wu XY, et al. title Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34 hematopoietic stem progenitor cells. journal Genome Res. volume 10 issue 10 pages ... associated with Myc are necessary for the inhibition of adenylyl cyclase activity. journal Mol ... more details
pmc 367714 url ref Transcription genetics Transcription of PVT1 is regulated by Myc . ref name pmid17503467 .... title The PVT 1 oncogene is a Myc protein target that is overexpressed in transformed cells. journal ... cite journal author Carramusa L, Contino F, Ferro A, et al. title The PVT 1 oncogene is a Myc protein ... far 3 of the c myc oncogene in a Burkitt s lymphoma 2 8 variant translocation is equivalent to the murine ... pmc 1167233 cite journal author Shtivelman E, Bishop JM title The PVT gene frequently amplifies with MYC ... more details
refimprove date December 2011 Infobox album See Wikipedia WikiProject Albums Name Answers Come in Dreams Type studio Artist Meat Beat Manifesto Cover Answers Come in Dreams.jpeg Released October 12, 2010 Recorded Genre Dubstep , Electronic music Electronic Length US version 1 13 05 br UK version 52 59 Label Metropolis Records br Hydrogen Dukebox Producer Jack Dangers Last album Autoimmune album Autoimmune 2008 This album Answers Come in Dreams 2010 Next album Album ratings rev1 Allmusic rev1score Rating 4 5 ref Allmusic class album id r1961579 pure url yes Allmusic review ref rev2 rev2score Answers Come in Dreams is an album by Meat Beat Manifesto . Track listing US CD Metropolis Luminol 6 05 Mnemonic 5 58 MYC 7 09 Let Me Set 5 40 Zero 4 37 Quietus 6 33 Token Words 6 48 Waterphone 9 23 010130 1 02 Zenta 5 09 Please 5 23 Chimie Du Son 9 18 UK CD Hydrogen Dukebox 010130 1 04 Quietus 4 30 Mnemonic 4 20 Luminol 6 04 Please 5 24 Zero 4 36 Token Words 6 50 Waterphone 8 05 Let Me Set 5 39 Chimie Du Son 6 27 Personnel Jack Dangers performer, producer Dave Dasher programming, sounds on MYC References reflist Category 2010 albums Category Meat Beat Manifesto albums ... more details
distinguish Nyanga language Infobox language name Nyanga li altname Gbati ri nativename Mayeka states Democratic Republic of the Congo region Orientale Province speakers 90,000 date 2002 2004 ethnicity familycolor Niger Congo fam2 Atlantic Congo languages Atlantic Congo fam3 Benue Congo languages Benue Congo fam4 Bantoid languages Bantoid fam5 Bantu languages Bantu Guthrie classification of Bantu languages Zone D Zone D fam6 lc1 nyc ld1 Nyanga li lc2 gti ld2 Gbati ri lc3 myc ld3 Mayeka Nyanga li Linyanga le , Gbati ri Gbote , and Mayeka form a dialect continuum of Bantu languages in Orientale Province , Democratic Republic of the Congo . DEFAULTSORT Nyanga Li Language Category Bantu languages Category Languages of the Democratic Republic of the Congo Nc lang stub sw Kinyanga li ... more details
Orphan date February 2009 PBB geneid 10260 C myc promoter binding protein is a protein that in humans is encoded by the DENND4A gene . ref name pmid8056341 cite journal author Stasiv YZ, Mashkova TD, Chernov BK, Sokolova IV, Itkes AV, Kisselev LL title Cloning of a cDNA encoding a human protein which binds a sequence in the c myc gene similar to the interferon stimulated response element journal Gene volume 145 issue 2 pages 267 72 year 1994 month Sep pmid 8056341 pmc doi 10.1016 0378 1119 94 90018 3 ref ref name pmid12906859 cite journal author Semova N, Kapanadze B, Corcoran M, Kutsenko A, Baranova A, Semov A title Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter binding protein new DENN domain containing protein family emerges small star, filled journal Genomics volume 82 issue 3 pages 343 54 year 2003 month Aug pmid 12906859 pmc doi 10.1016 S0888 7543 03 00103 4 ref ref name entrez cite web title Entrez Gene DENND4A DENN MADD domain containing 4A url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 10260 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Ewing RM, Chu P, Elisma F, et al. title Large scale mapping of human protein protein interactions by mass spectrometry. journal Mol. Syst. Biol. volume 3 issue 1 pages 89 year 2007 pmid 17353931 doi 10.1038 msb4100134 pmc 1847948 cite journal author Gerhard DS, Wagner L, Feingold EA, et al. title The status, quality, and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC . journal Genome Res. volume 14 issue 10B pages 2121 7 year 2004 pmid 15489334 doi 10.1101 gr.2596504 pmc 528928 cite journal author Jin J, Smith ... pmc 139241 cite journal author Uramoto H, Izumi H, Ise T, et al. title p73 Interacts with c Myc ... more details
PBB geneid 4150 Myc associated zinc finger protein is a protein that in humans is encoded by the MAZ gene . ref name pmid1567856 cite journal author Pyrc JJ, Moberg KH, Hall DJ title Isolation of a novel cDNA encoding a zinc finger protein that binds to two sites within the c myc promoter journal Biochemistry volume 31 issue 16 pages 4102 10 year 1992 month May pmid 1567856 pmc doi 10.1021 bi00131a029 ref ref name pmid1502157 cite journal author Bossone SA, Asselin C, Patel AJ, Marcu KB title MAZ, a zinc finger protein, binds to c MYC and C2 gene sequences regulating transcriptional initiation and termination journal Proc Natl Acad Sci U S A volume 89 issue 16 pages 7452 6 year 1992 month Sep pmid 1502157 pmc 49728 doi 10.1073 pnas.89.16.7452 ref ref name entrez cite web title Entrez Gene MAZ MYC associated zinc finger protein purine binding transcription factor url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 4150 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions MAZ gene has been shown to Protein protein interaction interact with BPTF ref name pmid10727212 cite journal doi 10.1021 bi992211q last Jordan Sciutto first ... Fetal Alz 50 clone 1 FAC1 protein interacts with the Myc associated zinc finger protein ZF87 MAZ and alters ... E, Murata T, Yokoyama K K year 2001 month Sep. title Interaction of Myc associated zinc finger protein ... Song J, Murakami H, Tsutsui H, et al. title Genomic organization and expression of a human gene for Myc ... activities of MAZ, a myc associated zinc finger protein, are regulated by casein kinase II. journal ... with the Myc associated zinc finger protein ZF87 MAZ and alters its transcriptional activity. journal ... journal author Ugai H, Li HO, Komatsu M, et al. title Interaction of Myc associated zinc finger protein ... Functional importance of Myc associated zinc finger protein for the human parathyroid hormone PTH PTH ... more details
may also repress the transcriptional activity of the proto oncogene c Myc. Alternatively spliced ... has been shown to Protein protein interaction interact with Myc . ref name pmid9792694 cite journal ... 1998 month Nov. title MM 1, a novel c Myc associating protein that represses transcriptional activity of c Myc journal J. Biol. Chem. volume 273 issue 45 pages 29794 29800 publisher location UNITED ..., Ariga H year 2001 month Nov. title MM 1, a c Myc binding protein, is a candidate for a tumor suppressor ... Myc binding protein, is a candidate for a tumor suppressor in leukemia lymphoma and tongue cancer journal ... H cite journal author Watanabe K title Physical interaction of p73 with c Myc and MM1, a c Myc binding ... c Myc journal J. Cell. Biochem. volume 97 issue 1 pages 145 155 year 2006 pmid 16173081 doi 10.1002 ... more details
laysource laydate quote ref and Myc . ref name pmid11283613 cite journal last Staller first ... J, H nel F, Eilers M year 2001 month April title Repression of p15INK4b expression by Myc through ... title An alternative pathway for gene regulation by Myc journal EMBO J. volume 16 issue 18 pages ... of Myc with the zinc finger protein Miz 1 defines a novel pathway for gene regulation by Myc ... by Myc. journal EMBO J. volume 16 issue 18 pages 5672 86 year 1997 pmid 9312026 doi 10.1093 ... A, et al. title Repression of p15INK4b expression by Myc through association with Miz 1. journal ... UV response by Myc through association with Miz 1. journal Mol. Cell volume 10 issue 3 pages 509 ... Alonso MJ, et al. title Myc represses differentiation induced p21CIP1 expression via Miz 1 dependent ... more details
of MYC by competing for MAX, another basic helix loop helix protein that binds to MYC and is required ... that reverses the suppressive effects of Mad family members on c myc journal Oncogene volume ... variant of Max on E box vs initiator element mediated regulation by c Myc journal Oncogene volume ... J, Brent R title Mxi1, a protein that specifically interacts with Max to bind Myc Max recognition ... interacts with Max to bind Myc Max recognition sites journal Cell volume 79 issue 2 pages following ... Agus N title An amino terminal domain of Mxi1 mediates anti Myc oncogenic activity and interacts ... a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c myc ... LQ title Expression of MXI1, a Myc antagonist, is regulated by Sp1 and AP2 journal J. Biol. Chem. volume ... AA last6 Wechsler first6 DS cite journal author Taj MM title Mxi1, a Myc antagonist, suppresses proliferation ... first7 Daniel S. cite journal author Yin X title Dynamic in vivo interactions among Myc network members ... more details
. This protein competes with MYC for binding to MAX to form a sequence specific DNA binding complex, acts as a transcriptional repressor while MYC appears to function as an activator and is a candidate ... effects of Mad family members on c myc journal Oncogene volume 16 issue 9 pages 1149 59 publisher ... Myc transcriptional activity journal Cell volume 72 issue 2 pages 211 22 publisher location ... Jan. title X ray structures of Myc Max and Mad Max recognizing DNA. Molecular bases of regulation ... citations cite journal author Grandori C, Cowley SM, James LP, Eisenman RN title The Myc Max Mad ... L scher B title Function and regulation of the transcription factors of the Myc Max Mad network ... partner for Max that antagonizes Myc transcriptional activity. journal Cell volume 72 issue 2 pages ... effects of Mad family members on c myc. journal Oncogene volume 16 issue 9 pages 1149 59 ... vs initiator element mediated regulation by c Myc. journal Oncogene volume 18 issue 15 pages 2489 98 ... journal author Nikiforov MA, Popov N, Kotenko I, et al. title The Mad and Myc basic domains are functionally ... doi 10.1074 jbc.M212298200 cite journal author Nair SK, Burley SK title X ray structures of Myc Max ... discovery of Max as a novel interacting partner of C EBPalpha a Myc Max Mad link. journal Leukemia ... more details
22 also targets Myc Binding Protein MYCBP . ref name pmid20562918 cite journal author Xiong J, Du Q, Liang Z title Tumor suppressive microRNA 22 inhibits the transcription of E box containing c Myc target genes by silencing c Myc binding protein journal Oncogene volume 29 issue 35 pages 4980 8 year 2010 pmid 20562918 doi 10.1038 onc.2010.241 ref This prevents transcription of c Myc target genes by silencing c MYCBP. However, c Myc also inhibits expression of miR 22 in a positive feedback loop ... cite journal author Cole MD, McMahon SB title The Myc oncoprotein a critical evaluation of transactivation ... more details
MBP may refer to Biology Major basic protein , a protein which in humans is encoded by the PRG2 gene Maltose binding protein , a part of the maltose maltodextrin system of Escherichia coli Mbp, an abbreviation for mega base pair s Myc binding protein 1, a protein encoded by the alpha enolase glycolytic enzyme Myelin basic protein , a protein believed to be important in the process of myelination of nerves in the central nervous system Mannan binding lectin also mannose or mannan binding protein , an important factor in innate immunity Milk basic protein , a milk protein fraction Media ManBearPig , the sixth episode of the tenth season of Comedy Central s South Park Million Book Project , a book digitization project, led by Carnegie Mellon University Murder by Pride , the eighth studio album by Stryper M sica Popular Brasileira , a trend in post Bossa Novaurban popular music Other MacBook Pro , a line of Macintosh portable computers by Apple Inc. Ministry of Public Security Poland Ministerstwo Bezpiecze stwa Publicznego , a Polish secret police, intelligence, and counter espionage service from 1945&ndash 1954 Modbus Plus, an extended version of the Modbus serial communications protocol published by Modicon in 1979 disambiguation de MBP fr MBP it MBP nl MBP ja MBP pl MBP ... more details
DNA has been implicated in the regulation of several genes. One, the c myc gene has been extensively ... regulation. A c myc promoter element, termed the nuclease sensitive element or NSE, can form ... be a dynamic participant in the transcription of the c myc gene. References Rich, A. 1993 . DNA ..., AJ 1994 .Triplex forming ability of a c myc promoter element predicts promoter strength. Arch. Biochem ... more details
a gene known as a viral onocogene normally near the cellular myc c myc gene. The c myc gene is normally ... as it drives the expression of the c myc gene. There is an example of an insertional mutagenesis ... more details
gene often mutated in cancer cells , Myc c Myc , influences the expression of several miRNAs encoded in a cluster on human chromosome 13. These miRNAs in turn affect the expression of a c Myc induced ... Mendell generated data on c Myc and miRNAs in collaboration with Kathryn O Donnell. Mendell and O Donnell ... more details
Highwire Hiw is an E3 ubiquitin ligase protein associated with neuromuscular junction growth. ref cite journal author Bloom, Joseph A. Bradley R. Miller Joshua R. Sanes Aaron DiAntonio title The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons journal Genes & Development pages 2593 2606 year 2007 month September pmid 17901218 doi 10.1101 gad.1592107 url volume 21 issue 20 pmc 2000324 ref It is frequently studied in Drosophila melanogaster . Its known ortholog s are PAM Disambiguation needed date June 2011 , RPM 1 , and PHR 1 . References Reflist cite journal author Wan HI, DiAntonio A, Fetter RD, Bergstrom K, Strauss R, Goodman CS title Highwire regulates synaptic growth in Drosophila journal Neuron volume 26 issue 2 pages 313 29 year 2000 month May pmid 10839352 doi 10.1016 S0896 6273 00 81166 6 url cite journal author Wang H title Characterization of zebrafish Esrom Myc binding protein 2 RCC1 like domain splice variants journal Mol Cell Biochem volume 339 issue 1 2 pages 191 199 year 2010 month February pmid 20143133 doi 10.1007 s11010 010 0385 x url DEFAULTSORT Highwire Protein Category Cell biology Category Neurobiology ... more details
PBB geneid 79813 Euchromatic histone lysine N methyltransferase 1 is a protein that in humans is encoded by the EHMT1 gene . ref name entrez cite web title Entrez Gene Euchromatic histone lysine N methyltransferase 1 url http www.ncbi.nlm.nih.gov sites entrez?db gene&cmd retrieve&list uids 79813 accessdate 2012 03 04T01 24 04.662 08 00 ref The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methylates the Lys 9 position of histone H3, which tags it for transcriptional repression. This protein may be involved in the silencing of MYC and E2F responsive genes and therefore could play a role in the G0 G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome 9q syndrome . Two transcript variants encoding different isoforms have been found for this gene. ref name entrez cite web title Entrez Gene Euchromatic histone lysine N methyltransferase 1 url http www.ncbi.nlm.nih.gov sites entrez?db gene&cmd retrieve&list uids 79813 accessdate 2012 03 04T01 24 04.662 08 00 ref References reflist Further reading refbegin 2 Cite pmid 12004135 Cite pmid 15805155 Cite pmid 16501248 Cite pmid 16702210 Cite pmid 16826528 Cite pmid 17403666 Cite pmid 18264113 Cite pmid 19010785 Cite pmid 19128641 Cite pmid 19264732 refend gene 9 stub Category EC 2.1.1 ... more details
MYC By Appointment Yoga Classes Complimentary paddle boats and kayaks, and beach cruiser bicycles Charter Boats from MYC s Marina Masterpiece Charters, My Mate, and Hattrick Private Yacht Cruises Lighthouse ... more details
transcription activation. TRRAP a central role in MYC c Myc transcription activation, and also participates in cell transformation by MYC. It is required for p53 TP53 , E2F1 , and E2F4 mediated transcription ... Forms Distinct Nuclear Complexes and Functions as a Critical c Myc Interacting Nuclear Cofactor for Oncogenic ... Sharon Y R, Martinez Ernest date May 2003 title c Myc transformation domain recruits the human ... format accessdate laysummary laysource laydate quote doi 10.1016 S0092 8674 01 00450 0 ref Myc , ref ... cofactor for the c Myc and E2F oncoproteins journal Cell volume 94 issue 3 pages 363 74 publisher ... hGCN5 to c Myc journal Mol. Cell. Biol. volume 20 issue 2 pages 556 62 publisher location UNITED ... Myc and E2F oncoproteins journal Cell volume 94 issue 3 pages 363 74 year 1998 pmid 9708738 doi 10.1016 ... Acetyltransferase hGCN5 to c Myc journal Mol. Cell. Biol. volume 20 issue 2 pages 556 62 year ... acetyltransferase recruitment and Myc dependent oncogenesis journal Genes Dev. volume 15 issue ... Nuclear Complexes and Functions as a Critical c Myc Interacting Nuclear Cofactor for Oncogenic ... Activation by Myc Family Oncoproteins journal Mol. Cell. Biol. volume 22 issue 14 pages 5054 63 ... author Liu X title c Myc transformation domain recruits the human STAGA complex and requires TRRAP ... more details
Chembox ImageFile Stauprimide.svg ImageSize 150px IUPACName N 2 S ,3 R ,4 R ,6 R 3 Methoxy 2 methyl 16,18 dioxo 29 oxa 1,7,17 triazaoctacyclo 12.12.2.1 sup 2,6 sup .0 sup 7,28 sup .0 sup 8,13 sup .0 sup 15,19 sup .0 sup 20,27 sup .0 sup 21,26 sup nonacosa 8,10,12,14,19,21,23,25,27 nonaen 4 yl N methylbenzamide IUPACName hidden yes OtherNames Section1 Chembox Identifiers CASNo 154589 96 5 CASNo Ref cascite correct CAS PubChem ChemSpiderID 24606051 SMILES C C 12 C H C H C C H O1 n3c4ccccc4c5c3c6n2c7ccccc7c6c8c5C O NC8 O N C C O c9ccccc9 OC InChI InChI 1S C35H28N4O5 c1 35 31 43 3 23 37 2 34 42 18 11 5 4 6 12 18 17 24 44 35 38 21 15 9 7 13 19 21 25 27 28 33 41 36 32 27 40 26 20 14 8 10 16 22 20 39 35 30 26 29 25 38 h4 16,23 24,31H,17H2,1 3H3, H,36,40,41 t23 ,24 ,31 ,35 m1 s1 Section2 Chembox Properties C 35 H 28 N 4 O 5 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Stauprimide is a semisynthesis semi synthetic structural analog analog of the staurosporine family of indolocarbazole s. Stauprimide was first published in 1994 as part of an extensive structure activity investigation to improve the selective inhibition of protein kinase C as a potential antitumor agent. ref cite journal doi 10.1016 0960 894X 94 80004 9 title Inhibitory activity and selectivity of staurosporine derivatives towards protein kinase C year 1994 last1 Caravatti first1 Giorgio last2 Meyer first2 Thomas last3 Fredenhagen first3 Andreas last4 Trinks first4 Uwe last5 Mett first5 Helmut last6 Fabbro first6 Doriano journal Bioorganic & Medicinal Chemistry Letters volume 4 issue 3 pages 399 404 ref More recently, stauprimide has been shown to increase the efficiency of the directed differentiation of mouse and human embryonic stem cells in synergy with defined extracellular signaling cues. Stauprimide interacts with NME2 PUF transcription factor to down regulate Myc c Myc expression, leading to differentiation of stem cells. ref cite journal p ... more details
Encyclopedia
top
