Unreferenced date July 2007 The TB StructuralGenomicsConsortium is a worldwide consortium of scientists developing a foundation for tuberculosis diagnosis and treatment by determining the 3 dimensional structures of protein s from M. tuberculosis . The consortium seeks to solve structures of proteins that are of great interest to the TB biology community. A major goal of the consortium is to have a putative function for every ORF in the TB genome . Activities As of June 2006, 82 TB protein structures have been determined, 15 since January 1, 2006. The database of linked structuralgenomicsstructural and functional genomics functional information that has been constructed using this information can form a lasting basis for understanding M. tuberculosis pathogenesis and for structure based drug design. As of June 2006, the TB StructuralGenomicsConsortium consists of 430 active members in 148 laboratories from 83 institutions across 15 countries. Consortium laboratories are collectively responsible for 3.3 of all protein structures in the Protein Data Bank and have extensive records of methods development. Consortium members have carried out a pilot project on the structuralgenomics of a hyperthermophile that has identified bottlenecks in the structure determination process and resulted in the development of methodologies for high throughput structure determination and analysis. The Consortium has 5 core facilities located at Lawrence Livermore National Laboratory , Los Alamos ... other members. External links http www.webtb.org Homepage Category Genomics Category Tuberculosis ..., crystallization and X ray data collection. Members of the consortium improve their productivity ... this activity to the database. This helps to minimize redundant pursuits of targets. This structural and functional information is publicly available. The 5 core facilities available to consortium members ... developed to record all activity done within the consortium. This database also tracks the movement ... more details
Nofootnotes article date April 2012 Primarysources article date April 2012 The StructuralGenomicsConsortium SGC is a not for profit organization formed in 2004 to determine the three dimensional structures of protein s of medical relevance, and place them in the Protein Data Bank without restriction on use. The SGC operates out of the Universities of University of Oxford Oxford and University of Toronto Toronto . Over the past five years, the SGC has accounted for 25 of the global output of novel human protein structures each year, and 40 of the annual global output of structures of proteins from human parasites. The SGC target proteins have relevance to human health and disease, such as diabetes , cancer and infectious diseases such as malaria . The SGC is supported by funding from the Wellcome Trust , GSK , Novartis , Eli Lilly , Pfizer , Takeda , Abbott , Life Technologies , the Canadian Institutes for Health Research CIHR , Canadian Foundation for Innovation CFI , Genome Canada, the Ontario s Ministry of Economic Development and Innovation MEDI . Recently, these organizations together have committed more than US 65 million to the consortium to sustain operation from 2011 2015. The SGC is also spearheading an open access chemistry partnership a new model for pre competitive drug discovery in which the public and private sectors collaborate to generate potent and selective pharmacological inhibitors of human proteins that regulate epigenetic signalling, and commit to make these reagents available without restriction on use. In 2011, the SGC launched a project to create high ... stub sv StructuralGenomicsConsortium ... doi 10.1016 j.cell.2008.11.038 title Large Scale Structural Analysis of the Classical Human Protein ... title Structural basis for recognition of hemi methylated DNA by the SRA domain of human UHRF1 ... cite journal doi 10.1016 j.cell.2008.07.047 title Structural Coupling of SH2 Kinase Domains Links ... more details
tuberculosis proteome The goal of the MycobacteriumTuberculosisStructuralGenomicsConsortium TB StructuralGenomicsConsortium is to determine the structures of potential drug targets in Mycobacterium ... for StructuralGenomicsMycobacteriumtuberculosisStructuralGenomicsConsortium http www.nysgxrc.org ... 2 3 Suppl S3 S10. Goulding CW et al . 2003. Structural genoimcs of Mycobacteriumtuberculosis a preliminary ... links div col StructuralGenomicsConsortium http www.nigms.nih.gov psi Protein Structure Initiative ... www.nesg.org Northeast StructuralGenomicsConsortium http www.mcsg.anl.gov The Midwest Center for Structural ...File Argonne s Midwest Center for StructuralGenomics deposits 1,000th protein structure.jpg An example of a protein structure determined by the Midwest Center for StructuralGenomics. thumb 300px Structural ... . The principal difference between structuralgenomics and protein structure prediction traditional structural prediction is that structuralgenomics attempts to determine the structure of every protein ... protein functions, structuralgenomics can be used to identify novel protein folds and potential targets for drug discovery. Structuralgenomics involves taking a large number of approaches to structure ... from its Three dimensional space 3D structure. Structuralgenomics emphasizes high throughput determination ... links centers of structuralgenomics . While most structural biologists pursue structures of individual proteins or protein groups, specialists in structuralgenomics pursue structures of proteins on a genome ... structures is at times questioned. A Science article from January 2006 analyzes the structuralgenomics field. ref cite journal author Chandonia JM, Brenner SE title The impact of structuralgenomics ... 347 ref One advantage of structuralgenomics, such as the Protein Structure Initiative , is that the scientific ... structuralgenomics centers. Goals One goal of structuralgenomics is to identify novel protein ... structure determination methods of structuralgenomics have the potential to inform our understanding ... more details
2009 chapter Hypervirulent Mycobacteriumtuberculosis title MycobacteriumGenomics and Molecular Biology publisher Caister Academic Press isbn 978 1 904455 40 0 ref Image Mycobacteriumtuberculosis Ziehl Neelsen stain 640.jpg thumb right Mycobacteriumtuberculosis stained red in tissue blue Microscopy ...About the bacterium the infection tuberculosis Italic title Taxobox color lightgrey name Mycobacterium ... M. tuberculosis binomial Mycobacteriumtuberculosis binomial authority Zopf 1883 synonyms Tubercle bacillus small Robert Koch Koch 1882 small Mycobacteriumtuberculosis MTB is a pathogen ic bacteria l species in the genus Mycobacterium and the causative agent of most cases of tuberculosis TB . ref ... Cole ST, Brosch R, Parkhill J, et al. title Deciphering the biology of Mycobacteriumtuberculosis from ... title Re annotation of the genome sequence of Mycobacteriumtuberculosis H37Rv journal Microbiology .... ref cite journal author JoAnne L Flynn and John Chany title Immune evasion by Mycobacteriumtuberculosis ... 978 1 904455 42 4 ref Strain variation M. tuberculosis comes from the genus Mycobacterium , which ... DNA polymorphisms in strains of Mycobacteriumtuberculosis analyzed by pulsed field gel electrophoresis ... and population genetic studies of Mycobacteriumtuberculosis . author Singh SP, Salamon H, Lahti ... Connell WA. title Genetic diversity in the Mycobacteriumtuberculosis complex based on variable numbers ... based typing as a portable approach to global analysis of Mycobacteriumtuberculosis molecular epidemiology ... repetitive unit typing of Mycobacteriumtuberculosis compared to IS6110 based restriction fragment ... interspersed repetitive unit variable number tandem repeat typing of Mycobacteriumtuberculosis ... strains Mycobacterium outbreaks are often caused by hypervirulent strains of M. tuberculosis ... Projects M tuberculosis title Mycobacteriumtuberculosis publisher Sanger Institute date 2007 ... retrieve pii S0092 8674 01 00236 7 ref Mycobacteriumtuberculosis sRNA Nine noncoding sRNAs have been ... more details
Mycobacteriumtuberculosis complex refers to a genetically closely related group of Mycobacterium species that can cause tuberculosis . It includes MycobacteriumtuberculosisMycobacterium africanum Mycobacterium bovis Mycobacterium bovis BCG Mycobacterium microti Mycobacterium canettii Mycobacterium pinnipedii Mycobacterium mungi . ref name pmid20350321 cite journal author Vasconcellos SE, Huard RC, Niemann S, et al. title Distinct genotypic profiles of the two major clades of Mycobacterium africanum journal BMC Infect. Dis. volume 10 issue pages 80 year 2010 pmid 20350321 pmc 2859774 doi 10.1186 1471 2334 10 80 url http www.biomedcentral.com 1471 2334 10 80 ref References Reflist Mycobacteria Mycobacterium stub Category Mycobacteria Category Tuberculosis ... more details
were shown to have important physiology physiological roles in M. tuberculosis . Overexpression of G2 sRNA, for example, prevented growth of M. tuberculosis and greatly reduced the growth of Mycobacterium ... R, Parkhill J, et al. title Deciphering the biology of Mycobacteriumtuberculosis from the complete ... a bioinformatics tool suggested 56 putative sRNAs in M. tuberculosis , though these have ... H3llBot ref Hfq protein homologues have yet to be found in M. tuberculosis ref cite journal author ... Biocomputational prediction of small non coding RNAs in Streptomyces journal BMC Genomics volume ... operon of Mycobacterium smegmatis is different from the Escherichia coli paradigm journal Microbiology ... 10.1099 mic.0.27597 0 url cite journal author Matsunaga I, Bhatt A, Young DC, et al. title Mycobacteriumtuberculosis pks12 Produces a Novel Polyketide Presented by CD1c to T Cells journal J. Exp. Med ... Navbox name hide the gallery title Gallery of M. tuberculosis small RNA secondary structure images ... more details
mbi.ucla.edu TB TB StructuralGenomicsConsortium Structures of Mycobacteriumtuberculosis proteins http kiev.physchem.kth.se MycDB.html MycDB Mycobacterium database http www.tbdb.org TBDB Tuberculosis ...italictitle Taxobox name Mycobacterium image Mycobacteriumtuberculosis 01.jpg image width 240px image caption Transmission electron microscopy TEM micrograph of M. tuberculosis . regnum Bacteria phylum Actinobacteria ordo Actinomycetales subordo Corynebacterineae familia Mycobacteriaceae genus Mycobacterium ... . Mycobacterium is a genus of Actinobacteria , given its own family, the Mycobacteriaceae. The genus includes pathogen s known to cause serious diseases in mammals, including tuberculosisMycobacteriumtuberculosis and leprosy Mycobacterium leprae . ref name Sherris cite book author Ryan KJ, Ray ... T, Brown A editors year 2009 title MycobacteriumGenomics and Molecular Biology publisher Caister .... The sequences of the genus Mycobacterium that matched most closely to those of M. tuberculosis were ... . Slowly growing Mycobacteriumtuberculosis complex Mycobacteriumtuberculosis complex MTBC members are causative agents of human and animal tuberculosis. Species in this complex include Mycobacteriumtuberculosis M. tuberculosis , the major cause of human tuberculosisMycobacterium bovis M. bovis ... Mycobacterium marinum , which has been shown to be motile within macrophage s that are characteristically ... showed sporulation in Mycobacterium marinum and perhaps in M. bovis . ref Ghosh, Jaydip, Pontus Larsson ... bacterium due to their lack of an outer cell membrane . All Mycobacterium species share a characteristic ... targets for new drugs for tuberculosis. ref name BhamidiS cite book author Bhamidi S year 2009 chapter ... Trends publisher Caister Academic Press isbn 978 1 904455 45 5 ref Many Mycobacterium species ... that does not intensify after light exposure. Ex M. tuberculosis , M. avium intra cellulare , M. bovis ... treated with chlorine and food sources. Some, however, including the tuberculosis and the leprosy ... more details
D014376 Tuberculosis , MTB , or TB short for tubercle Bacillus shape bacillus is a common, and in many cases lethal, infectious disease caused by various strains of mycobacterium mycobacteria , usually Mycobacteriumtuberculosis . ref name Robbins cite book author Kumar V, Abbas AK, Fausto N, Mitchell ... as miliary tuberculosis . ref name ID10 Causes Mycobacteria Main Mycobacteriumtuberculosis File Mycobacterium tuberculosis.jpg thumb Scanning electron micrograph of Mycobacteriumtuberculosis The main cause of TB is Mycobacteriumtuberculosis , a small, aerobic organism aerobic nonmotile bacillus ... 2005 cite journal author Herrmann J, Lagrange P title Dendritic cells and Mycobacteriumtuberculosis ... name Grosset cite journal author Grosset J title Mycobacteriumtuberculosis in the Extracellular ... diagnosis File TB in sputum.png thumb Mycobacteriumtuberculosis Ziehl Neelsen stain stained red ... author Rothel J, Andersen P title Diagnosis of latent Mycobacteriumtuberculosis infection is the demise ... of Mycobacteriumtuberculosis with extensive resistance to second line drugs worldwide, 2000 2004 journal ... 17,000 years ago. ref cite journal author Rothschild BM title Mycobacteriumtuberculosis ...pp semi indef pp move indef Infobox disease Name Tuberculosis Image Tuberculosis x ray 1.jpg Caption Chest X ray of a person with advanced tuberculosis DiseasesDB 8515 ICD10 ICD10 A 15 a 15 ICD10 A 19 ... isbn 978 1 4160 2973 1 ref Tuberculosis typically attacks the lung s but can also affect other parts ... A year 2010 title Testing for tuberculosis journal Australian Prescriber volume 33 issue 1 pages 12 ... organs causes a wide range of symptoms. Medical diagnosis Diagnosis of active TB relies on tuberculosis ... and or blood tests. Tuberculosis treatment Treatment is difficult and requires administration of multiple .... Antibiotic resistance is a growing problem in multi drug resistant tuberculosis multiple drug resistant tuberculosis MDR TB infections. Prevention relies on screening programs and vaccination ... more details
Merge from full genome sequencing discuss Talk Genomics Merger and splitting proposal date January 2012 About the scientific field the journal Genomics journal Genomics is a discipline in genetics concerned ... and biological research. Research of single genes does not fall into the definition of genomics unless ... Agency , the term genomics encompasses a broader scope of scientific inquiry associated technologies than when genomics was initially considered. A genome is the sum total of all an individual organism s genes. Thus, genomics is the study of all the genes of a cell, or tissue, at the DNA genotype ... Genomics Policy ref History The first genomes to be sequenced were those of a virus and a mitochondrion ..., data storage, and bioinformatic analyses in the 1970 1980s. A major branch of genomics is still ... created the possibility for the field of functional genomics , mainly concerned with patterns of gene ... science approach. The actual term genomics is thought to have been coined by Dr. Tom Roderick ... are all important model animals in medical research. Major research areas Bacteriophage genomics ... genome to be sequenced was a bacteriophage . However, bacteriophage research did not lead the genomics revolution, which is clearly dominated by bacterial genomics. Only very recently has the study ... Press year 2007 url http www.horizonpress.com phage isbn 978 1 904455 14 1 ref Cyanobacteria genomics ... The Cyanobacteria Molecular Biology, Genomics and Evolution edition 1st publisher Caister Academic Press year 2008 url http www.horizonpress.com cyan isbn 978 1 904455 15 8 ref Human genomics Main Human ... also be referred to as environmental genomics, ecogenomics or community genomics. While traditional ... with drugs. See also Computational genomics Epigenomics Full Genome Sequencing Functional genomicsGenomics of domestication Immunomics Metagenomics Nitrogenomics Personal genomics Proteomics Psychogenomics References reflist 2 External links http www.genomicsdirectory.com Genomics Directory ... more details
by mycobacteria Latent tuberculosis List of tuberculosis victims MycobacteriumTuberculosisStructuralGenomicsConsortium National Center for HIV, STD, and TB Prevention Nontuberculous mycobacteria ... which strains of Mycobacteriumtuberculosis are present in sputum has 98 per cent accuracy and can ... of Mycobacteriumtuberculosis genome sequences and related information. Kaiser Family Foundation ...Image Mycobacterium tuberculosis.jpg 100px right thumb Scanning electron micrograph of MycobacteriumtuberculosisTuberculosis is a major public health problem in People s Republic of China China . China has the world s second largest tuberculosis epidemic after India , but progress in tuberculosis control was slow during the 1990s. Detection of tuberculosis had stagnated at around 30 of the estimated total of new cases, and multidrug resistant tuberculosis was a major problem. These signs of inadequate tuberculosis control can be linked to a malfunctioning health system . The spread of severe ... tuberculosis. By 2005, the detection of cases of tuberculosis had increased to 80 of the estimated total new cases, permitting China to achieve the 2005 global tuberculosis control targets. At the same time, specific efforts to improve tuberculosis control also contributed to strengthening of the public ... government undertook a review of the tuberculosis situation in China, which looked at the progress in tuberculosis control before the SARS epidemic, outlined the measures taken to improve the public ... of tuberculosis control efforts, and discuss the challenges that China must address to halve the number of tuberculosis cases and deaths as part of the Millennium Development Goals MDGs . Epidemiology Image Tuberculosis prevalence WHO 2009.svg thumb upright 1.6 alt World map with sub Saharan Africa ... in sub Saharan Africa. ref cite book title Global tuberculosis control epidemiology ... In China, tuberculosis has been the number 1 cause of death from infectious disease in adults . In 1990 ... more details
Infobox disease Name Miliary tuberculosis Image Miliary Tuberculosis17260.jpg Caption Miliary tuberculosis is characterized by a chronic, contagious bacterial infection caused by Mycobacteriumtuberculosis ... 224278 Gram positive actinobacteria diseases Category Tuberculosis Category Mycobacterium related cutaneous ... Miliary tuberculosis also known as disseminated tuberculosis , ref name Bolognia cite book author Rapini ... location St. Louis year 2007 pages Chapter 74 isbn 1 4160 2999 0 oclc doi accessdate ref tuberculosis cutis acuta generalisata , ref name Bolognia and Tuberculosis cutis disseminata ref name Bolognia is a form of tuberculosis that is characterized by a wide dissemination into the human body and by the tiny ... seeds thus the term miliary tuberculosis. Miliary TB may infect any number of organs, including the lungs ... Dieter, Miliary Tuberculosis , http www.emedicine.com med topic1476.htm, October 3, 2006. ref Etiology Miliary tuberculosis is a form of tuberculous infection in the lung that is the result of erosion ... A patient with miliary tuberculosis will tend to present with non specific signs, such as low grade fever, cough, and Lymphadenopathy enlarged lymph nodes . Miliary tuberculosis can also present ... tuberculosis are being in direct contact with a person who has it, living in unsanitary conditions ..., Disseminated Tuberculosis http www.nlm.nih.gov medlineplus ency article 000624htm, December 3, 2008. ref Tests Testing for miliary tuberculosis is conducted in the same manner as for other forms of tuberculosis . Tests include chest x ray , sputum culture , bronchoscopy , TB skin test , open ... . ref name nlm.nih.gov A variety of neurological complications have been noted in miliary tuberculosis ... of patients improve following antituberculous treatment. Treatment main Tuberculosis treatment ... . Timebomb The Global Epidemic of Multi Drug Resistant Tuberculosis. Mcgraw Hill. ISBN 0 07 135924 9 The Treatment of Tuberculosis Albino, Juan & Reichman, Lee. Respiration Respiration 1998 65 237 ... more details
thumb Distinctive clusters of colorless Mycobacteriumtuberculosis form in this culture. A definitive diagnosis of tuberculosis can only be made by culturing Mycobacteriumtuberculosis organisms from ... for Detecting Mycobacteriumtuberculosis Infection, United States ref In general the US approach ... available tests are the amplified mycobacteriumtuberculosis direct test MTD, Gen Probe and Amplicor ... Mycobacteriumtuberculosis Direct Test in a Public Health Laboratory Test Performance and Impact ... practice of two commercial blood tests for diagnosis of infection with Mycobacteriumtuberculosis ... tracing and spatial tracking of Mycobacteriumtuberculosis infection by enumeration of antigen specific ... of T cell based assay with tuberculin skin test for diagnosis of Mycobacteriumtuberculosis infection ...for an overview of the disease Tuberculosis This article is in US English Tuberculosis is diagnosed by finding Mycobacteriumtuberculosis bacteria in a clinical specimen taken from the patient. While other investigations may strongly suggest tuberculosis as the diagnosis, they cannot confirm it. A complete medical evaluation for tuberculosis TB must include a medical history, a physical examination ... as 20 , or as many as 75 of pulmonary tuberculosis cases may be without symptoms. ref Burke and Parnell. Minimal Pulmonary Tuberculosis. 1948. 59 348 Canadian Medical Association Journal. ref Tuberculosis ... as probable or presumed . For a diagnosis negating the possibility of tuberculosis infection ... microscopy for tuberculosis a systematic review journal Lancet Infect Dis year 2006 volume 6 issue ... induction, gastric washing, and bronchoalveolar lavage for the diagnosis of pulmonary tuberculosis ... a sputum sample, common alternative sample sources for diagnosing pulmonary tuberculosis include ... reaction PCR or gene probe tests can distinguish M. tuberculosis from other mycobacteria. Even if sputum smear is negative, tuberculosis must be considered and is only excluded after negative cultures ... more details
about the type of voluntary association ref improve date September 2011 A consortium is an Voluntary association association of two or more individuals , companies , organizations or government s or any combination of these entities with the objective of participating in a common activity or pooling their resources for achieving a common goal. Consortium is a Latin word, meaning partnership , association ... Colleges Massachusetts Five Colleges, Inc. , along with the Claremont Consortium are among of the oldest ... at Amherst . Another example of a successful consortium is the Five Colleges of Ohio of Ohio Oberlin ... . The aforementioned Claremont Consortium known as the Claremont Colleges consists of Pomona College ... and administrative resources. An example of a non profit consortium is the Appalachian College Association ... consortium is a group of banks that collaborate to make a loan also known as a syndicate . This type of loan is more commonly known as a syndicated loan . In England it is common for a consortium ..., initially was a consortium of BP , ARCO , ConocoPhillips , Exxon , Mobil , Unocal Corporation Unocal ... as a consortium of aerospace manufacturers. The retention of production and engineering assets by the partner ... of, and subcontractors to, the consortium. The companies collaborated on development of the Airbus ... and competition. It is used when companies otherwise competitors collaborate in a consortium to cooperate ..., the GENIVI Alliance is a not for profit consortium between different car makers in order to ease building an in vehicle infotainment system. Another example is the World Wide Web Consortium World Wide Web Consortium W3C , which is a consortium that Standards organization standardizes World Wide Web ... Safety and Health is a consortium consisting of the Illinois Institute of Technology , the Food and Drug ... de Konsortium es Consorcio eo Konsorcio fa fr Consortium ko id Konsorsium it Consorzio kk lt Konsorciumas nl Consortium organisatievorm ja no Konsortium pl Konsorcjum ... more details
italic title Taxobox color lightgrey name Mycobacterium pinnipedii regnum Bacterium Bacteria phylum Actinobacteria ordo Actinomycetales subordo Corynebacterineae familia Mycobacterium Mycobacteriaceae genus Mycobacterium species M. pinnipedii binomial Mycobacterium pinnipedii binomial authority Cousins et al. 2003, ref name Cousins ATCC BAA 688 Mycobacterium pinnipedii is a member of the Mycobacteriumtuberculosis complex which primarily infects seals. It is a slowly growing Mycobacterium . The species is named after the Pinniped s, the organisms from which M. pinnipedii was first isolated. ref name Cousins cite journal last1 Cousins first1 DV last2 Bastida first2 R last3 Cataldi first3 A last4 Quse first4 V last5 Redrobe first5 S last6 Dow first6 S last7 Duignan first7 P last8 Murray first8 A last9 Dupont first9 C title Tuberculosis in seals caused by a novel member of the Mycobacteriumtuberculosis complex Mycobacterium pinnipedii sp. Nov journal International journal of systematic and evolutionary microbiology volume 53 issue Pt 5 pages 1305 14 year 2003 pmid 13130011 doi 10.1099 ijs.0.02401 0 ref References Reflist Mycobacteria DEFAULTSORT Mycobacterium Pinnipedii Category Acid fast bacilli Category Corynebacterineae Category Bacteria described in 2003 Mycobacterium stub ... more details
title Rural outbreaks of Mycobacteriumtuberculosis in a Canadian province journal Abstr Intersci ...File Tuberculosis world map DALY WHO2004.svg thumb 200px Age adjustment Age standardized death from tuberculosis ... legend ff4200 1000 2000 legend ff2c00 2000 3000 legend cb0000 3000 Multicol end File Tuberculosis ... in Asia. ref name WHO2009 Burden cite book title Global tuberculosis control epidemiology, strategy ... annex 3 en index.html title WHO report 2008 Global tuberculosis control accessdate 13 April 2009 ref Roughly a third of the world s population has been infected with M. tuberculosis , and new infections ... factsheets fs104 en index.html title Tuberculosis Fact sheet N 104 publisher World Health Organization date November 2010 accessdate 26 July 2011 ref However, not all infections with M. tuberculosis cause tuberculosis disease and many infections are asymptomatic. ref name CDC cite web publisher ... full.pdf ref Tuberculosis is the second most common cause of death from infectious disease after ... edition 7th ref The absolute number of tuberculosis cases has been decreasing since 2005 and new cases since 2002. ref name WHO2011 cite web title The sixteenth global report on tuberculosis url http ... name WHO2011a http www.who.int tb publications global report en index.html Global Tuberculosis Control , World Health Organization, 2011 ref The distribution of tuberculosis is not uniform across the globe ... cite book title Global tuberculosis control epidemiology, strategy, financing author World Health ... countries, tuberculosis is less common and is mainly an urban disease. In the United Kingdom ... were 30 per 100,000 in Portugal and Spain. These rates compared with 98 per 100,000 in Tuberculosis in China China and 48 per 100,000 in Brazil . In the United States, the overall tuberculosis case rate was 4 per 100,000 persons in 2007. ref name WHO2009 Burden In Canada, tuberculosis is still endemic ... global report 2006 pdf full report correctedversion.pdf title Global Tuberculosis Control Report ... more details
are all terms used to refer to tuberculosis throughout history. It is generally accepted that the microorganism originated from other, more primitive organisms of the same genus Mycobacterium . Contrary to previous findings stating that tuberculosis passed from animals to humans, scientific research has revealed that tuberculosis passed from humans to animals instead. Scientific work investigating the evolutionary origins of the Mycobacteriumtuberculosis complex has concluded that the most ... allowed dating of this Mycobacteriumtuberculosis complex evolutionary bottleneck to approximately ... of the Mycobacteriumtuberculosis complex. PLoS Pathog 4 9 e1000160. ref . Human bones from the Neolithic ... of 9,000 year old Mycobacteriumtuberculosis from a Neolithic settlement in the Eastern ... time the causal agent of the disease Mycobacteriumtuberculosis , or Koch s bacillus. ref Brock ... H, Nerlich A title Characterization of Mycobacteriumtuberculosis Complex DNAs from Egyptian Mummies ... from tuberculosis, depicts the social aspect of the disease, and its relation with living conditions ... out of Africa. This analysis of mycobacterial interspersed repetitive units also dated the Mycobacterium ... and Treatment of Tuberculosis in Antiquity journal Isis year 1940 month April volume 31 issue 2 pages 380 393 url http www.jstor.org stable 225758 ref White Plague The tuberculosis epidemic in Europe ... White Plague. Death by tuberculosis was considered inevitable, being the principal cause of death .... Tuberculosis in early civilization In 2008, evidence for tuberculosis infection has been discovered ... methods to date it is the oldest evidence of tuberculosis infection in humans. Evidence of the infection ... evidence of the type of angulation often seen with spinal tuberculosis. ref Madkour 2004 3 ref Some authors call tuberculosis the first disease known to mankind. Signs of the disease have also been ... evidence of spinal tuberculosis with the characteristic psoas dn date February 2012 abscesses. ref ... more details
Infobox disease Name Latent tuberculosis Image Caption DiseasesDB ICD10 ICD10 R 76 1 r 70 ICD9 ICD9 795.5 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Also called latent tuberculosis infection, latent TB or LTBI. Latent tuberculosis is where a patient is infected with Mycobacteriumtuberculosis , but does not have active tuberculosis disease. Patients with latent tuberculosis are not infectious it is not possible to get TB from someone with latent tuberculosis. The main risk is that approximately ... but higher risk if immunosuppressed will go on to develop active tuberculosis at a later stage of their life ... of tuberculosis, based on the risk of being infected with tubercle bacilli journal Adv Tuberc ... with latent TB is an important part of controlling this disease. Tests for latent tuberculosis There are currently two major classes of tests used to identify patients with latent tuberculosis tuberculin ... years after the first Mantoux test. Boosting occurs when people who have had remote infection with Mycobacteriumtuberculosis and or previous exposure to Bacille Calmette Guerin of Mycobacterium bovis BCG , an attenuated strain of Mycobacterium bovis that is used in some countries as a vaccine against tuberculosis, are given repeated tuberculin skin tests. In these people, the first test revives ..., there are multiple size thresholds for declaring a positive result of latent tuberculosis from ... of IGRA testing. blockquote Treatment Main tuberculosis treatment The treatment of latent tuberculosis .... In the U.S., physicians talk about latent tuberculosis treatment because the medication does not actually ... treatment for LTBI is started. To give treatment for latent tuberculosis to someone with active tuberculosis is a serious error the tuberculosis will not be adequately treated and there is a serious ... in children or persons with radiographic evidence of prior tuberculosis old fibrotic lesions 69 effective ... rifapentine isoniazid or daily rifampin pyrazinamide for latent tuberculosis in household contacts ... more details
italic title Context date October 2009 Taxobox name Mycobacterium aurum regnum Bacteria phylum Actinobacteria ordo Actinomycetales subordo Corynebacterineae familia Mycobacterium Mycobacteriaceae genus Mycobacterium species M. aurum binomial Mycobacterium aurum binomial authority Tsukamura 1966, ATCC 23366 Mycobacterium aurum is a species of acid fast , gram positive bacteria that forms long chains. Though related to Mycobacteriumtuberculosis , it does not cause tuberculosis . Genotype ATCC 23366 CCUG 37666 CIP 104465 DSM 43999 HAMBI 2275 JCM 6366 LMG 19255 NCTC 10437 NRRL B 4037. References SKERMAN V.B.D. , McGOWAN V. and SNEATH P.H.A. editors Approved Lists of Bacterial Names . International Journal of Systemic Bacteriology . 1980, 30, 225 420. TSUKAMURA M. Adansonian classification of mycobacteria . Journal of General Microbiology , 1966, 45, 253 273. PMID 4961417 Mycobacteria Category Acid fast bacilli Category Corynebacterineae Category Nontuberculous mycobacteria Mycobacterium stub ... more details
italic title Taxobox name Mycobacterium caprae regnum Bacteria phylum Actinobacteria ordo Actinomycetales subordo Corynebacterineae familia Mycobacterium Mycobacteriaceae genus Mycobacterium species M. caprae binomial Mycobacterium caprae binomial authority Aranaz et al. 2003, ref name pmid14657105 cite journal author Aranaz A, Cousins D, Mateos A, Dom nguez L title Elevation of Mycobacteriumtuberculosis subsp. caprae Aranaz et al. 1999 to species rank as Mycobacterium caprae comb. nov., sp. nov journal Int. J. Syst. Evol. Microbiol. volume 53 issue Pt 6 pages 1785 9 year 2003 month November pmid 14657105 doi url http ijs.sgmjournals.org cgi pmidlookup?view long&pmid 14657105 ref ATCC BAA 824 Mycobacterium caprae Type strain strain spc 1 gM 1 ATCC BAA 824 CIP 105776. Basonym Mycobacteriumtuberculosis subsp. caprae Aranaz et al. 1999. Other synonym Mycobacterium bovis subsp. caprae Aranaz et al. 1999 Niemann et al. 2002. It can cause tuberculosis . ref name pmid19919773 cite journal author Rodr guez E, S nchez LP, P rez S, et al. title Human tuberculosis due to Mycobacterium bovis and M. caprae in Spain, 2004 2007 journal Int. J. Tuberc. Lung Dis. volume 13 issue 12 pages 1536 41 year 2009 month December pmid 19919773 doi url http openurl.ingenta.com content nlm?genre article&issn 1027 3719&volume 13&issue 12&spage 1536&aulast Rodr guez ref References reflist Mycobacteria Tuberculosis Category Acid fast bacilli Category Corynebacterineae Category TuberculosisMycobacterium stub ... more details
Unreferenced stub auto yes date December 2009 Tuberculosis vaccines are vaccination s intended for the prevention of tuberculosis . There is currently only one tuberculosis vaccine available, bacille Calmette Gu rin BCG . Other tuberculosis vaccines in development are MVA85A rBCG30 72F fusion protein ESAT6 Ag85b fusion protein New vaccines are being developed by the TuBerculosis Vaccine Initiative TBVI and Aeras , among others. Vaccines DEFAULTSORT Tuberculosis Vaccines Category Vaccines Category Tuberculosis Vaccine stub ... more details
of Mycobacteriumtuberculosis journal Applied Microbiology volume 20 issue 5 pages 810 14 year 1970 ... to it. Isolated PZA resistance is uncommon in M. tuberculosis , but Mycobacterium bovis M. bovis ...Image Tuberculosis drugs and actions.jpg thumb right 300px Various pharmaceutical tuberculosis treatments their actions Tuberculosis treatment refers to the Therapy medical treatment of the infectious disease tuberculosis TB . The standard short course treatment for TB is isoniazid , rifampicin also ... there is still a relapse rate of 2 to 3 . For latent tuberculosis , the standard treatment is six ... font size 90 align right colspan 3 style text align center First line tuberculosis drugs Drug 3 letter ... text align center colspan 3 style text align center Second line tuberculosis drugs style text align ... expensive. The standard regimen Rationale and evidence for the standard regimen Tuberculosis ... in latent tuberculosis latent TB or chemoprophylaxis , and regimens that use only single drugs result ... title Streptomycin Treatment of Pulmonary Tuberculosis A Medical Research Council Investigation ... PR, Jan IS, et al. title Empirical treatment with a fluoroquinolone delays the treatment for tuberculosis ... A controlled trial of 6 months chemotherapy in pulmonary tuberculosis. Final report results during ... G, Raviglione MC, Maher D title Scale up meeting targets in global tuberculosis control journal ... month therapy for pulmonary and extrapulmonary tuberculosis. A twice weekly, directly observed, and cost ... the possibilities of tuberculosis from recurring, resulting in a reduction in unsuccessful treatments ... What is the limit to case detection under the DOTS strategy for tuberculosis control? journal Tuberculosis ... A authorlink2 Alimuddin Zumla title The global emergency of tuberculosis what is the cause? journal ... the DOTS framework has been so successful in the treatment of tuberculosis in sub Saharan Africa ... Adapting the DOTS framework for tuberculosis control to the management of non communicable diseases ... more details
italic title Taxobox name Mycobacterium microti regnum Bacteria phylum Actinobacteria ordo Actinomycetales subordo Corynebacterineae familia Mycobacterium Mycobacteriaceae genus Mycobacterium species M. microti binomial Mycobacterium microti binomial authority Reed 1957, ATCC 19422 Mycobacterium microti Member of the Mycobacteriumtuberculosis complex MTBC Also known as the Vole bacillus Etymology microtus is a genus that includes the vole . Description Gram positive , nonmotile and acid fast rods. Colony characteristics Variable colony morphology, buff in colour, either rough or smooth. Physiology Growth on glycerol free egg media at 37 C within 28 60 days. May adapt tolerance to glycerol. Sensitive to isoniazid , ethambutol , rifampin , streptomycin and pyrazinamide . Differential characteristics A commercial hybridisation assay AccuProbe to identify members of the M. tuberculosis complex exists. All members of the M. tuberculosis complex share identical 16S rDNA and internal transcribed spacers ITS sequences But molecular differentiation is possible by gyrB sequence polymorphism Pathogenesis Cause of naturally acquired generalized tuberculosis in voles . Recently van Soolingen et al. reported about the first infections among humans caused by M. microti Losing pathogenicity on repeated subculture. Biosafety level 3 Type strain Strain ATCC 19422 CIP 104256 NCTC 8710. References reflist Reed,G. 1957. Genus Mycobacterium species affecting warm blooded animals except those causing leprosy , In R.S. BREED, E.G.D. MURRAY and N.R. SMITH eds Bergey s Manual of Determinative Bacteriology, 7th edition, The Williams & Wilkins Co, Baltimore, 1957, p. 703 704. van Soolingen et al. , 1998. J. Clin. Microbiol. 36 1840 1845. Mycobacteria DEFAULTSORT Mycobacterium Microti Category Acid fast bacilli Category Corynebacterineae Category Tuberculous Mycobacteria Mycobacterium stub es Mycobacterium microti ... more details
italic title Taxobox name Mycobacterium moriokaense regnum Bacteria phylum Actinobacteria ordo Actinomycetales subordo Corynebacterineae familia Mycobacterium Mycobacteriaceae genus Mycobacterium species M. moriokaense binomial Mycobacterium moriokaense binomial authority Tsukamura et al. 1986, ATCC 43059 Mycobacterium moriokaense br Etymology moriokaense, from Morioka , Japan where the organism was first isolated. Description Gram positive , nonmotile and acid fast rods 2 6 m x 0.5 m . Colony characteristics Dry, rough and nonpigmented nonphotochromogenic colonies. Physiology Rapid growth on L wenstein Jensen media at 28 C, 37 C and 42 C, but not at 45 C within 3 days. Pathogenesis Biosafety level 1 Type strain First isolated from sputum of a patient with tuberculosis and from soil in Morioka, Japan. Strain NCH E11715 ATCC 43059 CCUG 37671 CIP 105393 DSM 44221 JCM 6375 VKM Ac 1183. References reflist Tsukamura et al. 1986. Mycobacterium moriokaense sp. nov., a rapidly growing, nonphotochromogenic Mycobacterium. Int. J. Syst. Bacteriol., 36, 333 338. Mycobacteria DEFAULTSORT Mycobacterium Moriokaense Category Acid fast bacilli Category Corynebacterineae Category Nontuberculous mycobacteria Mycobacterium stub ... more details
Vietnamese tuberculosis refers to certain forms of chronic melioidosis that look clinically very similar to tuberculosis . It is derived from the clinical appearance of the disease in American soldiers returning from the Vietnam war . Category Zoonotic bacterial diseases Category Bacterium related cutaneous conditions Infectious disease stub ... more details
Multiple issues refimprove August 2009 expert August 2009 orphan February 2009 confusing August 2009 Public genomics is a genomics branch that was initiated by public organizations such as governments, discontrol centers, and the United Nations UN . Public genomics is effectively the public facet of personal genomics . While personal genomics is geared more toward genomics resource personal and maximize the utility of genomics for the people, public genomics is geared toward to manage genome information and facilitate a more systematic and fair use of genome information in the society. See also Public health genomics External links http genomics.org index.php Public genomics Publicgenomics in Genomics.org Category Genomics ... more details
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