enzyme Name NADHdehydrogenase EC number 1.6.5.3 CAS number 9028 04 0 IUBMB EC number 1 6 5 3 GO code 0008137 image NADHdehydrogenase.png width caption Structure of NADHdehydrogenase Infobox protein family ... TCDB OPM family OPM protein CAZy CDD NADHdehydrogenase EC number 1.6.5.3 also referred to as NADH ... url issn pmc 2836797 ref Function Image ETC.PNG thumb 235px Electron transport chain. NADHdehydrogenase ... Dehydrogenase 2FUG.png thumb 235px The structure of the peripheral domain of a NADHdehydrogenase related ... in the mitochondrial matrix. Image NADHDehydrogenase 2FUG Electron Carriers Labeled.png thumb 235px ... cofactor. At the bottom, it should indicate Ubiquinone Ubiquinol. NADHDehydrogenase is the first ... enzymes in the electron transport chain NADHdehydrogenase Complex I , Coenzyme Q cytochrome ... location New York year 2006 pages 509 513 ref NADHdehydrogenase is the largest and most complicated ... issn ref The reaction of NADHdehydrogenase is NADH H sup sup CoQ 4H sup sup sub in sub NAD sup sup ... portion of NADHdehydrogenase. NADH initially binds to NADHdehydrogenase, and transfers ... are then transferred through the second prosthetic group of NADHdehydrogenase via a series of iron ... to be reduced to ubiquinol CoQH sub 2 sub . ref name Berg Composition and structure NADHDehydrogenase ... homologue to ubiquinone. Despite more than 50 years of study of NADHdehydrogenase, no inhibitors ... issn ref NADHdehydrogenase is also blocked by adenosine diphosphate ribose a reversible competitive ... NADHdehydrogenase Complex I journal The Biochemical Journal volume 301 issue pages 161 7 year ... dehydrogenase in mammalian mitochondria pass through Complex I to reduce NAD sup sup to NADH, driven ... 4159.2010.06631.x url issn ref Recent studies have examined other roles of NADHdehydrogenase ... The following is a list of humans genes that encode components of the NADHdehydrogenase ubiquinone complex NADHdehydrogenase ubiquinone 1 alpha subcomplex NDUFA1 NADHdehydrogenase ubiquinone 1 alpha ... more details
enzyme Name NADHdehydrogenase quinone EC number 1.6.99.5 CAS number 37256 36 3 IUBMB EC number 1 6 99 5 GO code 0050136 image width caption In enzymology , a NADHdehydrogenase quinone EC number 1.6.99.5 is an enzyme that catalysis catalyzes the chemical reaction NADH H sup sup acceptor math rightleftharpoons math NAD sup sup reduced acceptor The 3 substrate biochemistry substrates of this enzyme are nicotinamide adenine dinucleotide NADH , hydrogen ion H sup sup , and Electron acceptor acceptor , whereas its two product chemistry products are nicotinamide adenine dinucleotide NAD sup sup and reduced acceptor . This enzyme belongs to the family of oxidoreductase s, specifically those acting on NADH or NADPH with other acceptors. The systematic name of this enzyme class is NADH quinone acceptor oxidoreductase . Other names in common use include reduced nicotinamide adenine dinucleotide quinone dehydrogenase , NADH quinone oxidoreductase , NADH ubiquinone oxidoreductase , DPNH menadione reductase , D diaphorase , and NADH2 dehydrogenase quinone , and mitochondrial mt complex I . This enzyme participates in oxidative phosphorylation . Several compounds are known to enzyme inhibitor inhibit this enzyme , including Adenosine monophosphate AMP , and 2,4 Dinitrophenol . Structural studies As of late 2007, only one tertiary structure structure has been solved for this class of enzymes, with the Protein Data Bank PDB accession code PDB link 2FUG . References reflist 1 cite journal author Koli AK, Yearby C, Scott W, Donaldson KO date 1969 title Purification and properties of three separate menadione reductases from hog liver journal J. Biol. Chem. volume 244 pages 621&ndash 9 pmid 4388793 issue 4 1.6 enzyme stub Category EC 1.6.99 Category NADPH dependent enzymes Category NADH dependent enzymes Category Enzymes of known structure it NAD deidrogenasi chinone ja NADH ... more details
PBB geneid 4694 NADHdehydrogenase ubiquinone 1 alpha subcomplex subunit 1 is a protein that in humans is encoded by the NDUFA1 gene . ref name pmid8938439 cite journal author Zhuchenko O, Wehnert M, Bailey J, Sun ZS, Lee CC title Isolation, mapping, and genomic structure of an X linked gene for a subunit of human mitochondrial complex I journal Genomics volume 37 issue 3 pages 281 8 year 1997 month Mar pmid 8938439 pmc doi 10.1006 geno.1996.0561 ref ref name entrez cite web title Entrez Gene NDUFA1 NADHdehydrogenase ubiquinone 1 alpha subcomplex, 1, 7.5kDa url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 4694 accessdate ref Function The human NDUFA1 gene codes for an essential component of NADHdehydrogenase complex I of the electron transport chain respiratory chain , which transfers electrons from nicotinamide adenine dinucleotide NADH to ubiquinone . It has been noted that the N terminus N terminal hydrophobic domain has the potential to be folded into an alpha helix spanning the inner mitochondrion mitochondrial membrane with a C terminus C terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved sequence conserved two domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the hydrophobic protein HP fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function. ref name entrez References reflist Further reading refbegin 2 cite journal author Smeitink J, van den Heuvel L title Human mitochondrial complex I in health and disease. journal Am. J. Hum. Genet. volume 64 issue 6 pages 1505 10 year 1999 pmid 10330338 pmc 1377894 doi 10.1086 ... al. title cDNA of eight nuclear encoded subunits of NADH ubiquinone oxidoreductase human complex I ... more details
Infobox protein family Symbol CI B14 5a Name CI B14 5a image width caption Pfam PF07347 Pfam clan InterPro IPR009947 SMART PROSITE MEROPS SCOP TCDB OPM family OPM protein CAZy CDD In molecular biology, the NADH dehydrogenase ubiquinone 1 alpha subcomplex subunit 7 family of proteins also known as NADH ubiquinone oxidoreductase subunit B14.5a or Complex I B14.5a form a part of NADH dehydrogenase complex I . ref name pmid9878551 cite journal author Loeffen JL, Triepels RH, van den Heuvel LP, Schuelke M, Buskens CA, Smeets RJ, Trijbels JM, Smeitink JA title cDNA of eight nuclear encoded subunits of NADH ubiquinone oxidoreductase human complex I cDNA characterization completed journal Biochem. Biophys. Res. Commun. volume 253 issue 2 pages 415 22 year 1998 month December pmid 9878551 doi 10.1006 bbrc.1998.9786 url ref In mammals , it is encoded by the NDUFA7 gene. References reflist InterPro content IPR009947 Category Protein families ... more details
Unreferenced date November 2006 Orphan date February 2009 NADH Q is the name of a set of gene s encoding NADH coenzyme Q oxidoreductase NADH CoQ reductase proteins. In the human mitochondrial genome , genes 1 through 6, as well as 4L, have been identified. Category Genes Genetics stub ... more details
enzyme Name NADH kinase EC number 2.7.1.86 CAS number 62213 39 2 IUBMB EC number 2 7 1 86 GO code 0042736 image width caption In enzymology , a NADH kinase EC number 2.7.1.86 is an enzyme that catalysis catalyzes the chemical reaction ATP NADH math rightleftharpoons math ADP NADPH Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and nicotinamide adenine dinucleotide NADH , whereas its two product chemistry products are adenosine diphosphate ADP and nicotinamide adenine dinucleotide phosphate NADPH . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with an alcohol group as acceptor. The systematic name of this enzyme class is ATP NADH 2 phosphotransferase . Other names in common use include reduced nicotinamide adenine dinucleotide kinase phosphorylating , DPNH kinase , reduced diphosphopyridine nucleotide kinase , and NADH kinase . This enzyme has at least one effector biology effector , Acetate . References reflist 1 cite journal author Griffiths MM, Bernofsky C date 1972 title Purification and properties of reduced diphosphopyridine nucleotide kinase from yeast mitochondria journal J. Biol. Chem. volume 247 pages 1473&ndash 8 pmid 4335000 issue 5 enzyme stub Category EC 2.7.1 Category NADPH dependent enzymes Category Enzymes of unknown structure ... more details
enzyme Name NADH peroxidase EC number 1.11.1.1 CAS number 9032 24 0 IUBMB EC number 1 11 1 1 GO code 0016692 image Structure of NADH Peroxidase from Enterococcus faecalis.png width 296px caption The structure of NADH peroxidase from Enterococcus faecalis. Adapted from PDB 2NPX . In enzymology , a NADH peroxidase EC number 1.11.1.1 is an enzyme that catalysis catalyzes the chemical reaction NADH H sup ... function of NADH peroxidase is to inactivate H sub 2 sub O sub 2 sub generated within the cell, for example ... M, Hartke A title Comparative study of the physiological roles of three peroxidases NADH peroxidase ... substrate biochemistry substrates of this enzyme are nicotinamide adenine dinucleotide NADH , hydrogen ... among the flavin containing NADH peroxidases of group D streptococci. Analysis of the enzyme from Streptococcus ... acting on a peroxide as acceptor peroxidases . The systematic name of this enzyme class is NADH ... , diphosphopyridine nucleotide peroxidase , NADH peroxidase , nicotinamide adenine dinucleotide peroxidase , and NADH2 peroxidase . Structure The crystal structure of NADH peroxidase resembles glutathione ... FAD ref name Stehle 1993 cite journal author Stehle T, Claiborne A, Schulz GE title NADH binding site and catalysis of NADH peroxidase journal Eur. J. Biochem. volume 211 issue 1 2 pages 221 6 year 1993 month January pmid 8425532 doi 10.1111 j.1432 1033.1993.tb19889.x ref His10 of the NADH peroxidase ... cite journal author Yeh JI, Claiborne A title Crystal structures of oxidized and reduced forms of NADH ... acid ref name Yeh 2002 ref . Image Alignment of NADH, FAD and Cysteine 42 in NADH Peroxidase.png thumb 300px Alignment of NADH, FAD and Cysteine 42 in NADH Peroxidase, Adapted from PDB 2NPX Image Four residues essential for active site functionality in NADH Peroxidase.png thumb 300px Four residues essential for active site functionality in NADH Peroxidase, Adapted from PDB 2NPX Reaction mechanism The NADH peroxidase from Enterococcus faecalis is unique in that it utilizes the Cys42 thiol sulfenic ... more details
A dehydrogenase also called DHO in the literature is an enzyme that oxidise s a substrate biochemistry substrate by a reduction reaction that transfers one or more hydride s H sup sup to an electron acceptor, usually Nicotinamide adenine dinucleotide NAD sup sup NADP NADP sup sup or a Flavin group flavin coenzyme such as FAD or FMN . Examples aldehyde dehydrogenase acetaldehyde dehydrogenase alcohol dehydrogenase glutamate dehydrogenase an enzyme that can convert glutamate to Ketoglutarate and vice versa . lactate dehydrogenase pyruvate dehydrogenase a common enzyme that feeds the Citric acid cycle TCA Cycle in converting Pyruvate to Acetyl CoA glucose 6 phosphate dehydrogenase involved in the pentose phosphate pathway glyceraldehyde 3 phosphate dehydrogenase involved in glycolysis sorbitol dehydrogenase TCA cycle examples isocitrate dehydrogenase alpha ketoglutarate dehydrogenase succinate dehydrogenase malate dehydrogenase External links eMedicineDictionary Dehydrogenase Enzymes Category Oxidoreductases enzyme stub it Deidrogenasi de Dehydrogenasen es Deshidrogenasa fr D shydrog nase he ja pl Dehydrogenazy pt Desidrogenase ru sl Dehidrogenaza sv Dehydrogenas zh ... more details
enzyme Name orotate reductase NADH EC number 1.3.1.14 CAS number 37255 26 8 IUBMB EC number 1 3 1 14 GO code 0004589 image width caption In enzymology , an orotate reductase NADH EC number 1.3.1.14 is an enzyme that catalysis catalyzes the chemical reaction S dihydroorotate NAD sup sup math rightleftharpoons math orotate NADH H sup sup Thus, the two substrate biochemistry substrates of this enzyme are S dihydroorotate and nicotinamide adenine dinucleotide NAD sup sup , whereas its 3 product chemistry products are orotate , nicotinamide adenine dinucleotide NADH , and hydrogen ion H sup sup . This enzyme belongs to the family of oxidoreductase s, specifically those acting on the CH CH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is S dihydroorotate NAD oxidoreductase . This enzyme is also called orotate reductase NADH . This enzyme participates in pyrimidine metabolism . It has 2 cofactor biochemistry cofactors FAD , and FMN . References reflist 1 cite journal author FRIEDMANN HC, VENNESLAND B year 1958 title Purification and properties of dihydro orotic dehydrogenase journal J. Biol. Chem. volume 233 pages 1398&ndash 406 pmid 13610849 issue 6 cite journal author FRIEDMANN HC, VENNESLAND B year 1960 title Crystalline dihydroorotic dehydrogenase journal J. Biol. Chem. volume 235 pages 1526&ndash 32 pmid 13825167 cite journal author LIEBERMAN I, KORNBERG A year 1953 title Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I Dihydro orotic dehydrogenase journal Biochim. Biophys. Acta. volume 12 pages 223&ndash 34 pmid 13115431 doi 10.1016 0006 3002 53 90141 3 issue 1 2 Category EC 1.3.1 Category NADH dependent enzymes Category Flavin enzymes Category Enzymes of unknown structure 1.3 enzyme stub it Orotato reduttasi NAD ja NADH ... more details
enzyme Name methylglyoxal reductase NADH dependent EC number 1.1.1.78 CAS number 37250 16 1 IUBMB EC number 1 1 1 78 GO code 0019170 image width caption In enzymology , a methylglyoxal reductase NADH dependent EC number 1.1.1.78 is an enzyme that catalysis catalyzes the chemical reaction R lactaldehyde NAD sup sup math rightleftharpoons math methylglyoxal NADH H sup sup Thus, the two substrate biochemistry substrates of this enzyme are R lactaldehyde and nicotinamide adenine dinucleotide NAD sup sup , whereas its 3 product chemistry products are methylglyoxal , nicotinamide adenine dinucleotide NADH , and hydrogen ion H sup sup . This enzyme belongs to the family of oxidoreductase s, specifically those acting on the CH OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is R lactaldehyde NAD oxidoreductase . Other names in common use include methylglyoxal reductase , and D lactaldehyde dehydrogenase . This enzyme participates in pyruvate metabolism . References reflist 1 cite journal author TING SM, MILLER ON, SELLINGER OZ date 1965 title THE METABOLISM OF LACTALDEHYDE. VII. THE OXIDATION OF D LACTALDEHYDE IN RAT LIVER journal Biochim. Biophys. Acta. volume 97 pages 407&ndash 15 pmid 14323585 1.1.1 enzyme stub Category EC 1.1.1 Category NADH dependent enzymes Category Enzymes of unknown structure it Metilgliossale reduttasi dipendente da NAD ja NADPH ... more details
enzyme Name hydroxylamine reductase NADH EC number 1.7.1.10 CAS number 9032 06 8 IUBMB EC number 1 7 1 10 GO code 0050460 image width caption In enzymology , a hydroxylamine reductase NADH EC number 1.7.1.10 is an enzyme that catalysis catalyzes the chemical reaction NH sub 3 sub NAD sup sup H sub 2 sub O math rightleftharpoons math hydroxylamine NADH H sup sup The 3 substrate biochemistry substrates of this enzyme are ammonia NH sub 3 sub , nicotinamide adenine dinucleotide NAD sup sup , and water H sub 2 sub O , whereas its 3 product chemistry products are hydroxylamine , nicotinamide adenine dinucleotide NADH , and hydrogen ion H sup sup . This enzyme belongs to the family of oxidoreductase s, specifically those acting on other nitrogenous compounds as donors with NAD or NADP as acceptor. The systematic name of this enzyme class is ammonium NAD oxidoreductase . Other names in common use include hydroxylamine reductase , ammonium dehydrogenase , NADH hydroxylamine reductase , N hydroxy amine reductase , hydroxylamine reductase NADH2 , and NADH2 hydroxylamine oxidoreductase . This enzyme participates in nitrogen metabolism . References reflist 1 cite journal author Bernheim ML date 1969 title The hydroxylamine reductase of mitochondria journal Arch. Biochem. Biophys. volume 134 pages 408&ndash 13 pmid 4311180 doi 10.1016 0003 9861 69 90300 2 issue 2 cite journal author Bernheim ML, Hochstein P date 1968 title Reduction of hydroxylamine by rat liver mitochondria journal Arch. Biochem. Biophys. volume 124 pages 436&ndash 42 pmid 4298499 doi 10.1016 0003 9861 68 90349 4 issue 1 cite journal author Wang R and Nicholas DJD date 1986 title Some properties of nitrite and hydroxylamine reductases from Derxia gummosa journal Phytochemistry journal Phytochemistry volume 25 pages 2463&ndash 2469 doi 10.1016 S0031 9422 00 84489 1 issue 11 Category EC 1.7.1 Category NADH dependent ... NADH ... more details
enzyme Name fumarate reductase NADH EC number 1.3.1.6 CAS number 9076 99 7 IUBMB EC number 1 3 1 6 GO code 0016156 image width caption In enzymology , a fumarate reductase NADH EC number 1.3.1.6 is an enzyme that catalysis catalyzes the chemical reaction succinate NAD sup sup math rightleftharpoons math fumarate NADH H sup sup Thus, the two substrate biochemistry substrates of this enzyme are succinate and nicotinamide adenine dinucleotide NAD sup sup , whereas its 3 product chemistry products are fumarate , nicotinamide adenine dinucleotide NADH , and hydrogen ion H sup sup . This enzyme belongs to the family of oxidoreductase s, specifically those acting on the CH CH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is succinate NAD oxidoreductase . Other names in common use include NADH fumarate reductase , NADH dependent fumarate reductase , and fumarate reductase NADH . References reflist 1 cite journal author Hopgood MF and Walker DJ date 1969 title Succinic acid production by rumen bacteria. III. Enzymic studies on the formation of succinate by Ruminococcus flavefaciens journal Aust. J. Biol. Sci. volume 22 pages 1413&ndash 1424 1.3 enzyme stub Category EC 1.3.1 Category NADH dependent enzymes Category Enzymes of unknown structure it Fumarato reduttasi NAD ja NADH ... more details
enzyme Name tartrate dehydrogenase EC number 1.1.1.93 CAS number 37250 29 6 IUBMB EC number 1 1 1 93 GO code 0009027 image width caption In enzymology , a tartrate dehydrogenase EC number 1.1.1.93 is an enzyme that catalysis catalyzes the chemical reaction tartrate NAD sup sup math rightleftharpoons math oxaloglycolate NADH H sup sup Thus, the two substrate biochemistry substrates of this enzyme are tartrate and nicotinamide adenine dinucleotide NAD sup sup , whereas its 3 product chemistry products are oxaloglycolate , nicotinamide adenine dinucleotide NADH , and hydrogen ion H sup sup . This enzyme belongs to the family of oxidoreductase s, specifically those acting on the CH OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is tartrate NAD oxidoreductase . This enzyme is also called mesotartrate dehydrogenase . This enzyme participates in glyoxylate and dicarboxylate metabolism . It employs one cofactor biochemistry cofactor , manganese . References reflist 1 cite journal author Kohn LD, Packman PM, Allen RH, Jakoby WB date 1968 title Tartaric acid metabolism. V. Crystalline tartrate dehydrogenase journal J. Biol. Chem. volume 243 pages 2479&ndash 85 pmid 4297261 issue 10 1.1.1 enzyme stub Category EC 1.1.1 Category NADH dependent enzymes Category Manganese enzymes Category Enzymes of unknown structure it Tartrato deidrogenasi ja ... more details
enzyme Name glutamate synthase NADH EC number 1.4.1.14 CAS number 65589 88 0 IUBMB EC number 1 4 1 14 GO code 0016040 image width caption In enzymology , a glutamate synthase NADH EC number 1.4.1.14 is an enzyme that catalysis catalyzes the chemical reaction 2 L glutamate NAD sup sup math rightleftharpoons math L glutamine 2 oxoglutarate NADH H sup sup Thus, the two substrate biochemistry substrates of this enzyme are L glutamate and nicotinamide adenine dinucleotide NAD sup sup , whereas its 4 product chemistry products are L glutamine , 2 oxoglutarate , nicotinamide adenine dinucleotide NADH , and hydrogen ion H sup sup . This enzyme belongs to the family of oxidoreductase s, specifically those acting on the CH NH sub 2 sub group of donors with NAD sup sup or NADP sup sup as acceptor. This enzyme participates in glutamate metabolism and nitrogen metabolism . It employs one cofactor biochemistry cofactor , FMN . Nomenclature The systematic name of this enzyme class is L glutamate NAD sup sup oxidoreductase transaminating . Other names in common use include glutamate reduced nicotinamide adenine dinucleotide synthase, glutamate synthase NADH , L glutamate synthetase, NADH dependent glutamate synthase, NADH glutamate synthase, and NADH GOGAT, L glutamate synthase NADH . References reflist 1 cite journal author Boland MJ, Benny AG date 1977 title Enzymes of nitrogen metabolism in legume nodules. Purification and properties of NADH dependent glutamate synthase from lupin nodules journal Eur. J. Biochem. volume 79 pages 355&ndash 62 pmid 21790 doi 10.1111 j.1432 1033.1977.tb11816.x issue 2 1.4 enzyme stub Category EC 1.4.1 Category NADH dependent enzymes Category Flavin enzymes Category Enzymes of unknown structure it Glutammato sintasi NAD ja NADH ... more details
enzyme Name 3 Hydroxybutyrate dehydrogenase EC number 1.1.1.30 CAS number 9028 38 0 IUBMB EC number 1 1 1 30 GO code 0003858 image width caption In enzyme enzymology , a 3 hydroxybutyrate dehydrogenase EC number 1.1.1.30 is an enzyme that catalysis catalyzes the chemical reaction R 3 hydroxybutanoate NAD sup sup math rightleftharpoons math acetoacetate NADH H sup sup Thus, the two substrate biochemistry substrates of this enzyme are beta Hydroxybutyric acid R 3 hydroxybutanoate and nicotinamide adenine dinucleotide NAD sup sup , whereas its 3 product chemistry products are acetoacetic acid acetoacetate , nicotinamide adenine dinucleotide NADH , and hydrogen ion H sup sup . This enzyme belongs to the family of oxidoreductase s, to be specific, those acting on the CH OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is R 3 hydroxybutanoate NAD oxidoreductase . Other names in common use include NAD beta hydroxybutyrate dehydrogenase , hydroxybutyrate oxidoreductase , beta hydroxybutyrate dehydrogenase , D beta hydroxybutyrate dehydrogenase , D 3 hydroxybutyrate dehydrogenase , D 3 hydroxybutyrate dehydrogenase , beta hydroxybutyric acid dehydrogenase , 3 D hydroxybutyrate dehydrogenase , and beta hydroxybutyric dehydrogenase . This enzyme participates in ketone Biochemistry synthesis and degradation of ketone bodies and Butanoate Butanoate fermentation butanoate metabolism . Structural studies As of late 2007, two tertiary structure structures ... hydroxybutyrate dehydrogenase from Rhodopseudomonas spheroides journal Biochem. J. volume 102 pages ... 1965 title beta Hydroxybutyric dehydrogenase and dimer hydrolase of Pseudomonas lemoignei journal ... HC and Wise JB date 1960 title D beta Hydroxybutyric dehydrogenase of mitochondria journal J. Biol. Chem. volume 235 pages 2450 2455 pmid 14415394 1.1.1 enzyme stub Category EC 1.1.1 Category NADH dependent enzymes Category Enzymes of known structure de D beta Hydroxybutyrat Dehydrogenase it 3 idrossibutirrato ... more details
enzyme Name indolelactate dehydrogenase EC number 1.1.1.110 CAS number 37250 41 2 IUBMB EC number 1 1 1 110 GO code 0047722 image width caption In enzymology , an indolelactate dehydrogenase EC number 1.1.1.110 is an enzyme that catalysis catalyzes the chemical reaction indol 3 yl lactate NAD sup sup math rightleftharpoons math indol 3 yl pyruvate NADH H sup sup Thus, the two substrate biochemistry substrates of this enzyme are indol 3 yl lactate and nicotinamide adenine dinucleotide NAD sup sup , whereas its 3 product chemistry products are indol 3 yl pyruvate , nicotinamide adenine dinucleotide NADH , and hydrogen ion H sup sup . This enzyme belongs to the family of oxidoreductase s, specifically those acting on the CH OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is indol 3 yl lactate NAD oxidoreductase . This enzyme is also called indolelactate NAD oxidoreductase . This enzyme participates in tryptophan metabolism . References reflist 1 cite journal doi 10.1139 m68 068 author Jean M, DeMoss RD date 1968 title Indolelactate dehydrogenase from Clostridium sporogenes journal Can. J. Microbiol. volume 14 pages 429&ndash 35 pmid 4384683 issue 4 1.1.1 enzyme stub Category EC 1.1.1 Category NADH dependent enzymes Category Enzymes of unknown structure it Indololattato deidrogenasi ja ... more details
enzyme Name octanol dehydrogenase EC number 1.1.1.73 CAS number 9031 31 6 IUBMB EC number 1 1 1 73 GO code 0004552 image width caption In enzymology , an octanol dehydrogenase EC number 1.1.1.73 is an enzyme that catalysis catalyzes the chemical reaction 1 octanol NAD sup sup math rightleftharpoons math 1 octanal NADH H sup sup Thus, the two substrate biochemistry substrates of this enzyme are 1 octanol and nicotinamide adenine dinucleotide NAD sup sup , whereas its 3 product chemistry products are 1 octanal , nicotinamide adenine dinucleotide NADH , and hydrogen ion H sup sup . This enzyme belongs to the family of oxidoreductase s, specifically those acting on the CH OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is octanol NAD oxidoreductase . This enzyme is also called 1 octanol dehydrogenase . References reflist 1 cite journal author Roche B, Azoulay E date 1969 title Regulation of the alcohol dehydrogenases Saccharomyces cerevisiae journal Eur. J. Biochem. volume 8 pages 426&ndash 34 pmid 4308448 doi 10.1111 j.1432 1033.1969.tb00545.x issue 3 1.1.1 enzyme stub Category EC 1.1.1 Category NADH dependent enzymes Category Enzymes of unknown structure it Ottanolo deidrogenasi ja ... more details
enzyme Name uronate dehydrogenase EC number 1.1.1.203 CAS number 37250 98 9 IUBMB EC number 1 1 1 203 GO code 0050388 image width caption In enzymology , an uronate dehydrogenase EC number 1.1.1.203 is an enzyme that catalysis catalyzes the chemical reaction D galacturonate NAD sup sup H sub 2 sub O math rightleftharpoons math D galactarate NADH H sup sup The 3 substrate biochemistry substrates of this enzyme are D galacturonate , nicotinamide adenine dinucleotide NAD sup sup , and water H sub 2 sub O , whereas its 3 product chemistry products are D galactarate , nicotinamide adenine dinucleotide NADH , and hydrogen ion H sup sup . This enzyme belongs to the family of oxidoreductase s, specifically those acting on the CH OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is uronate NAD 1 oxidoreductase . Other names in common use include uronate NAD oxidoreductase , and uronic acid dehydrogenase . References reflist 1 cite journal author KILGORE WW, STARR MP date 1959 title Uronate oxidation by phytopathogenic pseudomonads journal Nature. volume 183 pages 1412&ndash 3 pmid 13657147 doi 10.1038 1831412a0 issue 4672 1.1.1 enzyme stub Category EC 1.1.1 Category NADH dependent enzymes Category Enzymes of unknown structure it Uronato deidrogenasi ja ... more details
enzyme Name 2 alkyn 1 ol dehydrogenase EC number 1.1.1.165 CAS number 54576 94 2 IUBMB EC number 1 1 1 165 GO code 0047535 image width caption In enzymology , a 2 alkyn 1 ol dehydrogenase EC number 1.1.1.165 is an enzyme that catalysis catalyzes the chemical reaction 2 butyne 1,4 diol NAD sup sup math rightleftharpoons math 4 hydroxy 2 butynal NADH H sup sup Thus, the two substrate biochemistry substrates of this enzyme are 2 butyne 1,4 diol and nicotinamide adenine dinucleotide NAD sup sup , whereas its 3 product chemistry products are 4 hydroxy 2 butynal , nicotinamide adenine dinucleotide NADH , and hydrogen ion H sup sup . This enzyme belongs to the family of oxidoreductase s, specifically those acting on the CH OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is 2 butyne 1,4 diol NAD 1 oxidoreductase . References reflist 1 cite journal author Miyoshi T, Sato H and Harada T date 1974 title Purification and characterization of 2 alkyne 1 ol dehydrogenase induced by 2 butene 1,4 diol in Fusarium merismoides B11 journal Biochim. Biophys. Acta volume 358 pages 231&ndash 239 1.1.1 enzyme stub Category EC 1.1.1 Category NADH dependent enzymes Category Enzymes of unknown structure it 2 alchino 1 olo deidrogenasi ja 2 1 ... more details
enzyme Name sabinol dehydrogenase EC number 1.1.1.228 CAS number 111940 50 2 IUBMB EC number 1 1 1 228 GO code 0047502 image width caption In enzymology , a sabinol dehydrogenase EC number 1.1.1.228 is an enzyme that catalysis catalyzes the chemical reaction cis sabinol NAD sup sup math rightleftharpoons math sabinone NADH H sup sup Thus, the two substrate biochemistry substrates of this enzyme are sabinol cis sabinol and nicotinamide adenine dinucleotide NAD sup sup , whereas its 3 product chemistry products are sabinone sabinone , nicotinamide adenine dinucleotide NADH , and hydrogen ion H sup sup . This enzyme belongs to the family of oxidoreductase s, specifically those acting on the CH OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is cis sabinol NAD oxidoreductase . This enzyme is also called cis sabinol dehydrogenase . References reflist 1 cite journal author Dehal SS, Croteau R date 1987 title Metabolism of monoterpenes specificity of the dehydrogenases responsible for the biosynthesis of camphor, 3 thujone, and 3 isothujone journal Arch. Biochem. Biophys. volume 258 pages 287&ndash 91 pmid 3310901 doi 10.1016 0003 9861 87 90346 8 issue 1 1.1.1 enzyme stub Category EC 1.1.1 Category NADH dependent enzymes Category Enzymes of unknown structure it sabinolo deidrogenasi ja ... more details
enzyme Name lysine dehydrogenase EC number 1.4.1.15 CAS number 68073 29 0 IUBMB EC number 1 4 1 15 GO code 0050069 image width caption In enzymology , a lysine dehydrogenase EC number 1.4.1.15 is an enzyme that catalysis catalyzes the chemical reaction L lysine NAD sup sup math rightleftharpoons math 1,2 didehydropiperidine 2 carboxylate NH sub 3 sub NADH H sup sup Thus, the two substrate biochemistry substrates of this enzyme are L lysine and nicotinamide adenine dinucleotide NAD sup sup , whereas its 4 product chemistry products are 1,2 didehydropiperidine 2 carboxylate , ammonia NH sub 3 sub , nicotinamide adenine dinucleotide NADH , and hydrogen ion H sup sup . This enzyme belongs to the family of oxidoreductase s, specifically those acting on the CH NH2 group of donors with NAD or NADP as acceptor. The systematic name of this enzyme class is L lysine NAD oxidoreductase deaminating, cyclizing . References reflist 1 cite journal author Burgi W, Richterich R, Colombo JP date 1966 title L Lysine dehydrogenase deficiency in a patient with congenital lysine intolerance journal Nature. volume 211 pages 854&ndash 5 pmid 4291003 doi 10.1038 211854a0 issue 5051 1.4 enzyme stub Category EC 1.4.1 Category NADH dependent enzymes Category Enzymes of unknown structure it Lisina deidrogenasi ja ... more details
enzyme Name monodehydroascorbate reductase NADH EC number 1.6.5.4 CAS number 9029 26 9 IUBMB EC number 1 6 5 4 GO code 0016656 image width caption In enzymology , a monodehydroascorbate reductase NADH EC number 1.6.5.4 is an enzyme that catalysis catalyzes the chemical reaction NADH H sup sup 2 monodehydroascorbate math rightleftharpoons math NAD sup sup 2 ascorbate The 3 substrate biochemistry substrates of this enzyme are nicotinamide adenine dinucleotide NADH , hydrogen ion H sup sup , and monodehydroascorbate, whereas its two product chemistry products are nicotinamide adenine dinucleotide NAD sup sup and ascorbate . This enzyme belongs to the family of oxidoreductase s, specifically those acting on NADH or NADPH with a quinone or similar compound as acceptor. The systematic name of this enzyme class is NADH monodehydroascorbate oxidoreductase. Other names in common use include NADH semidehydroascorbic acid oxidoreductase, MDHA, semidehydroascorbate reductase, AFR, AFR reductase, ascorbic free radical reductase, ascorbate free radical reductase, SOR, MDAsA reductase NADPH , SDA reductase, NADH ascorbate radical oxidoreductase, NADH semidehydroascorbate oxidoreductase, ascorbate free radical reductase, NADH AFR oxidoreductase, and monodehydroascorbate reductase NADH2 . This enzyme participates in ascorbate and aldarate metabolism. In plants, the monodehydroascorbate reductase MDAR is an enzymatic component of the glutathione ascorbate cycle that is one of the major antioxidant systems of plant cells for the protection against the damages produced by reactive oxygen species ROS . The MDAR activity has been described in several cell compartments, such as chloroplast s, cytosol ... author Schulze HU, Schott HH, Staudinger H date 1972 title The isolation and characterization of a NADH ... Category NADPH dependent enzymes Category NADH dependent enzymes Category Enzymes of unknown structure it Monodeidroascorbato reduttasi NAD ja NADH ... more details
enzyme Name glycerol dehydrogenase EC number 1.1.1.6 CAS number 9028 14 2 IUBMB EC number 1 1 1 6 GO code 0008888 image 1jqa assembly.png width caption Glycerol dehydrogenase from B. stearothermophilus with glycerol spheres Protein Data Bank PDB 1jqa In enzymology , a glycerol dehydrogenase EC number 1.1.1.6 is an enzyme that catalysis catalyzes the chemical reaction glycerol NAD sup sup math rightleftharpoons math glycerone NADH H sup sup Thus, the two substrate biochemistry substrates of this enzyme are glycerol and nicotinamide adenine dinucleotide NAD sup sup , whereas its three product chemistry products are glycerone , nicotinamide adenine dinucleotide NADH , and hydrogen ion H sup sup . This enzyme belongs to the family of oxidoreductase s, specifically those acting on the CH OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is glycerol NAD 2 oxidoreductase . Other names in common use include glycerin dehydrogenase , and NAD linked glycerol dehydrogenase . This enzyme participates in glycerolipid metabolism . Structural studies Structural studies have shown that the enzyme is zinc dependant with the active site lying between the two domains of the protein. The NAD binding site resembles the Rossmann fold ref Glycerol dehydrogenase. structure, specificity, and mechanism of a family III polyol dehydrogenase. Ruzheinikov et al. Structure ... for this class of enzyme can be found in the info box. See also Glycerol dehydrogenase NADP Glycerol dehydrogenase acceptor References reflist 1 cite journal author ASNIS RE, BRODIE AF year 1953 title A glycerol dehydrogenase from Escherichia coli journal J. Biol. Chem. volume 203 pages 153&ndash ... dehydrogenase from Aerobacter aerogenes journal J. Am. Chem. Soc. volume 75 pages 1005&ndash ... of glycerol dehydrogenase from Aerobacter aerogenes by monovalent cations journal J. Biol. Chem. volume 235 pages 1820&ndash 1823 pmid 14417009 Category EC 1.1.1 Category NADH dependent enzymes ... more details
enzyme Name tryptophan dehydrogenase EC number 1.4.1.19 CAS number 94047 13 9 IUBMB EC number 1 4 1 19 GO code 0050363 image width caption In enzymology , a tryptophan dehydrogenase EC number 1.4.1.19 is an enzyme that catalysis catalyzes the chemical reaction L tryptophan NAD P H sub 2 sub O math rightleftharpoons math indol 3 yl pyruvate NH sub 3 sub NAD P H H sup sup The 4 substrate biochemistry substrates of this enzyme are L tryptophan , nicotinamide adenine dinucleotide NAD sup sup , nicotinamide adenine dinucleotide phosphate NADP sup sup , and water H sub 2 sub O , whereas its 5 product chemistry products are indol 3 yl pyruvate , ammonia NH sub 3 sub , nicotinamide adenine dinucleotide NADH , nicotinamide adenine dinucleotide phosphate NADPH , and hydrogen ion H sup sup . This enzyme belongs to the family of oxidoreductase s, specifically those acting on the CH NH2 group of donors with NAD or NADP as acceptor. The systematic name of this enzyme class is L tryptophan NAD P oxidoreductase deaminating . Other names in common use include NAD P L tryptophan dehydrogenase , L tryptophan dehydrogenase , L Trp dehydrogenase , and TDH . This enzyme has at least one effector biology effector , calcium . References reflist 1 cite journal author Vackova K, Mehta A and Kutacek M date 1985 title Tryptophan aminotransferase and tryptophan dehydrogenase activities in some cell compartments of spinach leaves the effect of calcium ions on tryptophan dehydrogenase journal Biol. Plant. volume 27 pages 154&ndash 158 doi 10.1007 BF02902153 issue 2 3 1.4 enzyme stub Category EC 1.4.1 Category NADPH dependent enzymes Category NADH dependent enzymes Category Enzymes of unknown structure it Triptofano deidrogenasi ja ... more details
enzyme Name indole 3 acetaldehyde reductase NADH EC number 1.1.1.190 CAS number 58875 06 2 IUBMB EC number 1 1 1 190 GO code 0047018 image width caption In enzymology , an indole 3 acetaldehyde reductase NADH EC number 1.1.1.190 is an enzyme that catalysis catalyzes the chemical reaction indol 3 yl ethanol NAD sup sup math rightleftharpoons math indol 3 yl acetaldehyde NADH H sup sup Thus, the two substrate biochemistry substrates of this enzyme are indol 3 yl ethanol and nicotinamide adenine dinucleotide NAD sup sup , whereas its 3 product chemistry products are indol 3 yl acetaldehyde , nicotinamide adenine dinucleotide NADH , and hydrogen ion H sup sup . This enzyme belongs to the family of oxidoreductase s, specifically those acting on the CH OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is indol 3 yl ethanol NAD oxidoreductase . Other names in common use include indoleacetaldehyde reductase , indole 3 acetaldehyde reductase NADH , and indole 3 ethanol NAD oxidoreductase . This enzyme participates in tryptophan metabolism . References reflist 1 cite journal author Brown HM, Purves WK date 1976 title Isolation and characterization of indole 3 acetaldehyde reductases from Cucumis sativus journal J. Biol. Chem. volume 251 pages 907&ndash 13 pmid 2607 issue 4 1.1.1 enzyme stub Category EC 1.1.1 Category NADH dependent enzymes Category Enzymes of unknown structure it Indolo 3 acetaldeide reduttasi NAD ja 3 NADH ... more details
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