Neurotrophic factors are a family of proteins that are responsible for the growth and survival of developing neurons and the maintenance of mature neurons. Recent research has proven that neurotrophic factors promote the initial growth and development of neurons in the central nervous system and peripheral nervous system and that they are capable of regrowing damaged neurons in test tubes and animal models 1 . Neurotrophic factors are often released by the target tissue in order to guide the growth of developing axons. Most neurotrophic factors belong to one of three families 1 neurotrophins , 2 glial cell line derived neurotrophic factor family ligands GFLs , and 3 neuropoietic cytokines 1 . Each family has its own distinct signaling family though the cellular responses elicited often do overlap 1 . Currently, neurotrophic factors are being intensely studied for use in bioartificial nerve conduits because they are necessary in vivo for directing axon growth and regeneration. In studies, neurotrophic factors are normally used in conjunction with other techniques such as biological and physical cues created by the addition of cells and specific topographies. The neurotrophic factors may or may not be immobilized to the scaffold structure, though immobilization is preferred because it allows for the creation of permanent, controllable gradients. In some cases, such as neural drug delivery systems , they are loosely immobilized such that they can be selectively released at specified times and in specified amounts. References 1.Deister, C. and C.E. Schmidt, Optimizing neurotrophic factor combinations for neurite outgrowth. Journal of Neural Engineering, 2006. 3 p. 172 179. Category Neurochemistry fr Facteur neurotrophe ... more details
PBB geneid 4099 protein Name myelin associated glycoprotein caption image width HGNCid 6783 Symbol MAG AltSymbols GMA EntrezGene 4099 OMIM 159460 RefSeq NM 080600 UniProt P20916 PDB ECnumber Chromosome 19 Arm q Band 13.1 LocusSupplementaryData Myelin associated glycoprotein MAG, Siglec 4 is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO 66 receptor, NgR . ref cite journal author Quarles RH title Myelin associated glycoprotein MAG past, present and beyond journal Journal of Neurochemistry volume 100 issue 6 pages 1431 48 year 2007 pmid 17241126 doi 10.1111 j.1471 4159.2006.04319.x ref MAG is believed to be involved in myelination during nerve regeneration. ref cite journal author Barton D, Arquint M, Roder J, Dunn R, Francke U title The myelin associated glycoprotein gene mapping to human chromosome 19 and mouse chromosome 7 and expression in quivering mice journal Genomics volume 1 issue 2 pages 107 12 year 1987 pmid 2447011 doi 10.1016 0888 7543 87 90002 4 ref See also Myelin External links MeshName Myelin associated glycoprotein References references Category Lectins Category SIGLEC lectins Cell membrane proteins gene 19 stub nl Myeline gebonden glycoprote ne ... more details
Infobox Organization name Portland Press image size caption abbreviation motto formation extinction status purpose location Charles Darwin House, 12 Roger Street, London, WC1N 2JL region served membership leader title leader name main organ parent organization affiliations budget website http www.portlandpress.com Portland Press remarks Portland Press Limited is the wholly owned publishing subsidiary of The Biochemical Society . It is a not for profit publisher of journals and books in the cellular and molecular life sciences. The surplus from the sales of its publications are returned to the scientific community via the activities of The Biochemical Society. Portland Press publishes books, a magazine, The Biochemist , and several print and online academic journals ASN NEURO the journal of the American Society for Neurochemistry Biochemical Journal Biochemical Society Symposia online only Biochemical Society Transactions Biology of the Cell Cell Signalling Biology Clinical Science journal Clinical Science Essays in Biochemistry Bioscience Reports External links http www.portlandpress.com pp default.htm Portland Press http www.biochemistry.org Biochemical Society Category Book publishing companies of the United Kingdom ... more details
italictitle Infobox Journal title Sexologies European Journal of Sexual Health Revue Europ enne de Sant Sexuelle cover Image sexologies cover.gif abbreviation discipline Sexology language English language English , French language French website http www.elsevier.com wps find journaldescription.cws home 707397 description description publisher Elsevier country editor Mireille Bonierbale , Robert Porto history 1992 frequency quarterly impact impact year link1 link1 name Online access ISSN 1158 1360 eISSN RSS The Sexologies European Journal of Sexual Health Revue Europ enne de Sant Sexuelle is a Peer review peer reviewed scientific journal published by Elsevier and is the official journal for the European Federation of Sexology EFS . Its co Editors in Chief are Mireille Bonierbale and Robert Porto . Articles in Sexologies contain original, synthetic articles on human sexuality, its dysfunctions and its management. The journal is interdisciplinary in nature, including contributions from anatomy and physiology psychodynamic, cognitive, behavioural, and relational psychology epidemiology sociology forensics and the neurochemistry of substances that have sexological effects. It is indexed in Bibliosex and EMBASE Excerpta Medica. External links http www.elsevier.com wps find journaldescription.cws home 707397 description Journal homepage http www.europeansexology.com Official site of the European Federation of Sexology Category Publications established in 1992 Category Sexology journals Category Elsevier academic journals Category Quarterly journals sex stub sci journal stub ... more details
Immunoglobulin superfamily CAMs IgSF CAMs are a class of cell adhesion molecule s. ref name LajthaBanik2007 cite book author1 Abel Lajtha author2 Naren L. Banik author3 Naren Banik title Handbook of neurochemistry and molecular neurobiology Neural protein metabolism and function url http books.google.com books?id dsxMGtc3iRQC&pg PA41 accessdate 28 November 2010 year 2007 publisher isbn 9780387303468 pages 41 ref They are either homophilic or heterophilic and bind integrins or different IgSF CAMs. Examples Here is a list of some molecules of this family SynCAM s Synaptic Cell Adhesion Molecules NCAM s Neural Cell Adhesion Molecules ICAM 1 Intercellular Cell Adhesion Molecule VCAM 1 Vascular Cell Adhesion Molecule PECAM 1 Platelet endothelial Cell Adhesion Molecule L1 protein L1 CHL1 Myelin associated glycoprotein MAG Nectin Nectins and nectin like molecules CD2 CD48 The SIGLEC family e.g. CD22 , CD83 The CTX family e.g. CTX, Junctional adhesion molecule JAM s, BT IgSF, Coxsackie virus and adenovirus receptor CAR , VSIG, ESAM gene ESAM References reflist Cell adhesion molecules Category Cell adhesion molecules ... more details
Chembox ImageFile 3 hydroxycyclopent 1 enecarboxylic acid.svg ImageSize 180px ImageAlt IUPACName 3 Hydroxycyclopent 1 enecarboxylic acid OtherNames Section1 Chembox Identifiers CASNo 867178 11 8 CASNo Ref cascite correct PubChem ChemSpiderID 26333262 SMILES C1CC CC1O C O O InChI 1 C6H8O3 c7 5 2 1 4 3 5 6 8 9 h3,5,7H,1 2H2, H,8,9 InChIKey VKJGQKRRULDFCI UHFFFAOYAO StdInChI 1S C6H8O3 c7 5 2 1 4 3 5 6 8 9 h3,5,7H,1 2H2, H,8,9 StdInChIKey VKJGQKRRULDFCI UHFFFAOYSA N Section2 Chembox Properties C 6 H 8 O 3 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition HOCPCA 3 hydroxycyclopent 1 enecarboxylic acid is a compound with an affinity for the GHB receptor 39 times greater than that of Gamma Hydroxybutyric acid GHB itself. ref name wellendorph cite journal journal The Journal of Pharmacology and Experimental Therapeutics volume 315 issue 1 pages 346 351 year 2005 url http jpet.aspetjournals.org content 315 1 346.full.pdf format pdf title Novel Cyclic Hydroxybutyrate GHB Analogs with High Affinity and Stereoselectivity of Binding to GHB Sites in Rat Brain author Petrine Wellendorph, Signe H g, Jeremy R. Greenwood, Anne de Lichtenberg, Birgitte Nielsen, Bente Fr lund, Lotte Brehm, Rasmus P. Clausen and Hans Br uner Osborne doi 10.1124 jpet.105.090472 ref See also T HCA References references GHBergics Category Nervous system Category Neurochemistry Category Carboxylic acids biochemistry stub ... more details
& Drugs, 2005 Medical Consequences of Addiction, 2005 Marijuana Neurochemistry & Physiology, 2006 Methamphetamine Neurochemistry and Recovery, 2007 Neurochemistry of Relapse and Recovery, 2008 10 part series Use, Abuse and Addiction 2009 Drug and Behavioral Addictions Roots of Addiction The Neurochemistry ... more details
of the American Society for Neurochemistry Biochemical Journal Biochemical Society Symposia online ... news jclark.htm Biochemical Journal Centenary http www.asneurochem.org American Society for Neurochemistry ... more details
File Thudichum.jpg thumb Johann Ludwig Wilhelm Thudichum. Johann Ludwig Wilhelm Thudichum August 27, 1829 &ndash September 7, 1901 was a German physician and biochemist who was a native of B dingen . He studied medicine in Giessen , where he also worked in the laboratory of chemist Justus von Liebig 1803 1873 . In 1853 he moved to London , where he worked for the remainder of his career. Thudichum was a pioneer in the field of neurochemistry , and a founder of brain chemistry . He performed chemical analyses of over one thousand human and animal brains, and specialized in pathology pathological chemistry. He is credited with the identification and characterization of numerous compounds of the brain , including cephalin , sphingomyelin , galactose , lactic acid and sphingosine . In 1884 he described his research in a publication titled A Treatise on the Chemical Constitution of the Brain , which was widely criticized and rejected at the time by many in the scientific community. After his death, the discoveries from Thudichum s research have been realized as important scientific contributions to the study of the chemical and molecular composition of the brain. Thudichum published over eighty works, including books on non medical topics such as viticulture and cookery . He also devised a specialized nasal speculum medical speculum that is still in use by physicians today. Since 1974 the Thudichum Medal Lecture is awarded in England for outstanding achievements in the field of neurochemistry, and at Yale University , the Thudichum Post Doctoral Research Fellowship in Neuro oncology is granted for the research of brain tumor s. Selected writings A treatise on the pathology of urine , London, John Churchill, 1858 A treatise on the origin, nature, and varieties of wine being a complete manual of viticulture and oenology , London, New York, Macmillian, 1872 A treatise on the chemical constitution of the brain , London, Bailliere, Tindall and Cox, 1884 The progress of medica ... more details
Journal of Neurochemistry year 2003 month December volume 87 issue Suppl. 1 pages 68 68 pmid pmc ref ... in morphine addiction journal Journal of Neurochemistry year 2004 month February volume 88 issue ... Wall and its CNS depressant effect particularly in morphine addiction journal Journal of Neurochemistry ... wall. in view of its role in morphine addiction journal Journal of Neurochemistry year 2005 month ... Pharmacological study of delphinium denudatum wall. in morphine de addiction. journal Journal of Neurochemistry ... more details
Disorders Mental Health & Drugs 2005 Medical Consequences of Addiction 2005 Marijuana Neurochemistry & Physiology 2006 Methamphetamine Neurochemistry and Recovery 2007 Neurochemistry of Relapse and Recovery ... The Neurochemistry of the Roots of Addiction 2011 Six part series Driving Under the Influence ... more details
Council ref Vizi works as Editor in chief of Neurochemistry International and as Section Editor of the Brain ... 264.7 macrophages and in endotoxemic mice co author, 1996 Neurochemistry and pharmacology of the major ... coauthor, 2001 Handbook of neurochemistry and molecular neurobiology Neurotransmitter systems ... more details
Multiple issues notability August 2011 orphan June 2009 BLP sources June 2006 Frank A. Gerbode wrote of a method known as traumatic incident reduction TIR . citation needed date January 2011 He is an Honors graduate of Stanford University and later pursued graduate studies in philosophy at Cambridge University . He received his medical degree from Yale University , and completed a psychiatric residency at Stanford University Medical Center in the early 1970s. Gerbode is the author of numerous papers and articles, which have been published in the Journal of Neurochemistry , the International Journal of Neuropharmacology , the Journal of Rational Emotive and Cognitive Behavioral Therapy , IRM Newsletter and elsewhere. They include at least one article in Nature journal Nature ref Bowers, M. B., & Gerbode, F. A. 1968 . Relationship of Monoamine Metabolites in Human Cerebrospinal Fluid to Age. Nature. 219, 1256 1257. ref He teaches and lectures internationally, and is the author of Beyond Psychology An Introduction to Metapsychology ISBN 1 887927 00 X , published in 1988. ref http www.worldcat.org title beyond psychology an introduction to metapsychology oclc 81457333&referer brief results WorldCat ref This book provided the first published description of TIR. He edited the special issue Trauma treatment techniques innovative trends ref http www.worldcat.org title trauma treatment techniques innovative trends oclc 57069556&referer brief results WorldCat ref of Haworth Press s Journal of aggression, maltreatment & trauma, From 1986 to 1995, Gerbode founded the Institute for Research in Metapsychology and the Center for Applied Metapsychology in Palo Alto, California. citation needed date January 2011 Today, this function is fulfilled by the Traumatic Incident Reduction Association, ref http www.tir.org Traumatic Incident Reduction Association TIRA Bot generated title ref a division of Applied Metapsychology International. Gerbode currently resides in Sonoma, California . ... more details
Unreferenced date June 2007 Robert Nalbandyan 1937 2002 was an Armenians Armenian chemist, the co discoverer of photosynthetic protein plantacyanin, a pioneer in the field of free radicals , and a noted and prolific writer on various subjects in the field of chemistry . Born in Yerevan , Armenia and educated at Moscow State University in Moscow, Russia , Nalbandyan lived and worked in Yerevan for most of his life, where he also headed a laboratory and lectured. He was recognized as one of Soviet Union s most prominent chemists, and in his research collaborated with fellow chemists in the USSR, US, Europe and Australia. When the Armenian Soviet Socialist Republic SSR struck for independence in 1989, Nalbandyan became a prominent critic of the nationalist movement, which he felt was foolhardy and was merely agitating the people for political gain. The energy shortage, economic woes, and virtual blockade experienced by the tiny republic after independence seemed to justify his concerns. In 1996 he left the country and emigrated to the United States . Primarily known in the scientific community for his research work with proteins , Nalbandyan was also recognized among his fellow scientists as a progressive thinker in other fields of chemistry, including neurochemistry . Persondata Metadata see Wikipedia Persondata . NAME Nalbandyan, Robert ALTERNATIVE NAMES SHORT DESCRIPTION DATE OF BIRTH 1937 PLACE OF BIRTH DATE OF DEATH 2002 PLACE OF DEATH DEFAULTSORT Nalbandyan, Robert Category 1937 births Category 2002 deaths Category People from Yerevan Category Moscow State University alumni Category Armenian emigrants to the United States Category American chemists Category Armenian chemists Category American people of Armenian descent Category Armenian academics ... more details
The vesicular monoamine transporter VMAT is a transport protein integrated into the membrane of intracellular vesicles of synapse presynaptic neurons . It acts to transport monoamines into the synaptic vesicle s. Isoforms The two Protein isoform isoforms are VMAT1 VMAT2 Monoamines Monoamines transported by VMATs are mainly noradrenaline , adrenaline and isoprenaline . However, other substrates include dopamine , 5 HT , guanethidine and MPP . ref name Rang167 cite book author Rang, H. P. title Pharmacology publisher Churchill Livingstone location Edinburgh year 2003 pages isbn 0 443 07145 4 oclc doi Page 167 ref Clinical significance VMAT can be inhibited by reserpine , tetrabenazine ref name Rang167 and ibogaine ref name urlThe Ibogaine Dossier. Pharmacology of Ibogaine cite web url http ibogaine.desk.nl alkaloids.html title The Ibogaine Dossier. Pharmacology of Ibogaine format work accessdate ref . VMAT is the main target of methamphetamine . By acting as a competitive antagonist , methamphetamine blocks the presynaptic cell s ability to use VMAT to package the above mentioned neurotransmitters into vesicles. The result is increased neurotransmitter release that is not dependent on the phasic activity of the presynaptic cell. External links MeshName Vesicular Monoamine Transport Proteins References reflist Further reading cite journal author Kilbourn MR title In vivo radiotracers for vesicular neurotransmitter transporters journal Nucl. Med. Biol. volume 24 issue 7 pages 615 9 year 1997 pmid 9352531 doi 10.1016 S0969 8051 97 00101 7 cite journal author Weihe E, Eiden LE title Chemical neuroanatomy of the vesicular amine transporters journal FASEB J. volume 14 issue 15 pages 2435 49 year 2000 pmid 11099461 doi 10.1096 fj.00 0202rev Neurotransmitter transporters Adrenergics Dopaminergics Histaminergics Serotonergics Category Neurochemistry Category Signal transduction Category Receptors Category Neurotransmitter transporters Category Biogenic amines Category Integral ... more details
Yvnge Zotterman 20 September 1898 in Vadstena 13 March 1982 in Stockholm ref cite book last Zotterman first Yngve title Touch, Tickle and Pain, Part I publisher Pergamon Press date 1969 location Oxford page 269 ref ref cite journal last Knut Schmidt Nielsen Schmidt Nielsen first Knut title Yngve Zotterman journal The Physiologist date 1982 volume 25 issue 5 pages 431 url http www.the aps.org publications tphys legacy 1982 issue5 431.pdf format PDF accessdate 2008 06 02 ref was a Swedish neurophysiologist who received his medical training at the Karolinska Institute . He conducted pioneering studies on nerve conduction. He then worked on sensory function of skin, particularly related to pain and heat and neurochemistry of taste buds . ref cite book last Zotterman first Yngve title Touch, Tickle and Pain, Part II publisher Pergamon Press date 1971 location Oxford page 293 ref He was elected a member of the Royal Swedish Academy of Engineering Sciences in 1949, and of the Royal Swedish Academy of Sciences in 1953. See also Rate coding References references Persondata Metadata see Wikipedia Persondata . NAME Zotterman, Yngve ALTERNATIVE NAMES SHORT DESCRIPTION Swedish neuroscientist DATE OF BIRTH 20 September 1898 PLACE OF BIRTH DATE OF DEATH 13 March 1982 PLACE OF DEATH DEFAULTSORT Zotterman, Yngve Category 1898 births Category 1982 deaths Category Swedish neuroscientists Category Karolinska Institutet alumni Category Members of the Royal Swedish Academy of Engineering Sciences Category Members of the Royal Swedish Academy of Sciences med bio stub Sweden bio stub de Yngve Zotterman sv Yngve Zotterman ... more details
Calcium binding proteins are protein s that participate in calcium signaling calcium cell signalling pathways by binding to Ca sup 2 sup . The most ubiquitous Ca sup 2 sup sensing protein, found in all eukaryotic organisms including yeasts , is calmodulin . Intracellular storage and release of Ca sup 2 sup from the sarcoplasmic reticulum is associated with the high capacity, low affinity calcium binding protein calsequestrin . ref Siegel, George Ed. . Basic neurochemistry molecular, cellular and medical aspects . Lippincott Williams and Wilkins 1999 ISBN 0 397 51820 X ref With their role in signal transduction, calcium binding proteins contribute to all aspects of the cell s functioning, from homeostasis to learning and memory. For example, the neuron specific calexcitin has been found to have an excitatory effect on neuron s, and interacts with proteins that control the firing state of neurons, such as the voltage dependent potassium channel . ref cite journal author Nelson T, Cavallaro S, Yi C, McPhie D, Schreurs B, Gusev P, Favit A, Zohar O, Kim J, Beushausen S, Ascoli G, Olds J, Neve R, Alkon D title Calexcitin a signaling protein that binds calcium and Guanosine triphosphate GTP , inhibits potassium channels , and enhances membrane excitability journal Proceedings of the National Academy of Sciences PNAS volume 93 issue 24 pages 13808 13 year 1996 pmid 8943017 doi 10.1073 pnas.93.24.13808 pmc 19433 ref See also Vitamin D dependent calcium binding protein Wikipedia MeSH D12.776 MeSH D12.776.157.125 calcium binding proteins References Reflist External links MeshName Calcium Binding Proteins Note calcium binding proteins have now been seen in the dietary supplement market such as Apoaequorin http www.prevagen.com Prevagen . Carrier proteins Calcium binding proteins Category Proteins Category Calcium signaling ja ... more details
Use dmy dates date January 2011 MedalTableTop MedalSport Women s Athletics sport athletics MedalBronze 1995 World Championships in Athletics 1995 Gothenburg 4x400m relay MedalCompetition Commonwealth Games MedalGold 1998 Commonwealth Games 1998 Kuala Lumpur Athletics at the 1998 Commonwealth Games 4x400 m relay MedalBottom Lee Michelle Naylor born 26 January 1971 in Shepparton, Victoria is a retired middle distance Running runner from Australia . She qualified to the quarterfinals in the 400 metres at the 1996 Summer Olympics before finishing 8th and ran on her national 4x400 metres relay team that finished 6th in the qualifying round. At the 2000 Summer Olympics she repeated qualifying to the quarterfinals then finishing 8th in the quarterfinals. ref http www.sports reference.com olympics athletes na lee naylor 1.html ref At the 1995 World Championships in Athletics her relay team captured the bronze medal. She ran the 3rd leg on her relay team at the 1998 Commonwealth Games that won gold. She also set her personal record at 51.35 that year. At the 1999 World Championships in Athletics she was disqualified for a lane violation. ref http www.abc.net.au olympics 2000 profiles LEENAYLOR.htm ABC Profile ref Naylor received a doctorate in neurochemistry at Melbourne University. References Reflist Persondata Metadata see Wikipedia Persondata . NAME Naylor, Lee ALTERNATIVE NAMES SHORT DESCRIPTION Australian sprinter DATE OF BIRTH 26 January 1971 PLACE OF BIRTH DATE OF DEATH PLACE OF DEATH DEFAULTSORT Naylor, Lee Category 1971 births Category Living people Category Australian middle distance runners Category Athletes track and field at the 1996 Summer Olympics Category Athletes track and field at the 2000 Summer Olympics Category Athletes track and field at the 1994 Commonwealth Games Category Athletes track and field at the 1998 Commonwealth Games Category Olympic athletes of Australia Category People from Shepparton Category Commonwealth Games gold medallists for Austral ... more details
Chembox Verifiedfields changed Watchedfields changed verifiedrevid 416477221 ImageFile Beta oxalylamino L alanine.svg ImageSize 200px IUPACName 3 Carboxycarbonyl amino small L small alanine OtherNames Oxalylamino small L small alanine BOAA L BOAA N Oxalyl small L small , diaminopropionic acid ODAP beta ODAP small L small Dencichin Section1 Chembox Identifiers CASNo 5302 45 4 CASNo Ref cascite changed ?? PubChem 440259 ChemSpiderID Ref chemspidercite changed chemspider ChemSpiderID 389238 SMILES O C NC C H N C O O C O O InChI InChI 1S C5H8N2O5 c6 2 4 9 10 1 7 3 8 5 11 12 h2H,1,6H2, H,7,8 H,9,10 H,11,12 t2 m0 s1 Section2 Chembox Properties C 5 H 8 N 2 O 5 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Oxalyldiaminopropionic acid ODAP , a structural analogue of the neurotransmitter glutamate , is the neurotoxin responsible for lathyrism . ref Cite journal pmid 11850107 year 2002 last1 Ravindranath first1 V title Neurolathyrism Mitochondrial dysfunction in excitotoxicity mediated by L beta oxalyl aminoalanine volume 40 issue 6 pages 505 9 journal Neurochemistry international ref See also Beta Methylamino L alanine Methylamino small L small alanine , a related toxin References reflist organic compound stub Category Amino acids Category Dicarboxylic acids Category Neurotoxins de Oxalyldiaminopropions ure fa it Acido ossalildiamminopropionico ... more details
chembox verifiedrevid 425043996 ImageFile MRS1706 structure.png ImageSize 200px IUPACName N 4 Acetylphenyl 2 4 2,3,6,7 tetrahydro 2,6 dioxo 1,3 dipropyl 1H purin 8 yl phenoxy acetamide OtherNames MRS 1706 Section1 Chembox Identifiers CASNo 264622 53 9 PubChem SMILES CCCn1c2nc nc2c O n c1 O CCC c3ccc cc3 OCC O Nc4ccc C C O cc4 Section2 Chembox Properties Formula C sub 27 sub H sub 29 sub N sub 5 sub O sub 5 sub MolarMass 503.56 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition MRS 1706 is a selective inverse agonist for the adenosine Adenosine A2B receptor A sub 2B sub Receptor biochemistry receptor . ref Li Q, Ye K, Blad CC, den Dulk H, Brouwer J, Ijzerman AP, Beukers MW. ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor. Journal of Pharmacology and Experimental Therapeutics . 2007 Feb 320 2 637 45. PMID 17077318 ref It inhibits release of interleukin s and has an antiinflammatory effect. ref Vazquez JF, Clement HW, Sommer O, Schulz E, van Calker D. Local stimulation of the adenosine A2B receptors induces an increased release of IL 6 in mouse striatum an in vivo microdialysis study. Journal of Neurochemistry . 2008 May 105 3 904 9. PMID 18088370 ref ref Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Dikov MM, Blackburn MR, Biaggioni I, Feoktistov I. Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells. Journal of Immunology . 2008 Jun 1 180 11 7212 20. PMID 18490720 ref References reflist 2 Adenosinergics Category Xanthines Category Phenol ethers Category Acetanilides Category Aromatic ketones antineoplastic drug stub fa ... more details
Enkephalinases are enzyme s which degrade endogenous enkephalin opioid peptide s. They include Aminopeptidase N APN ref name pmid18855623 cite journal author Thanawala V, Kadam VJ, Ghosh R title Enkephalinase inhibitors potential agents for the management of pain journal Current Drug Targets volume 9 issue 10 pages 887 94 year 2008 month October pmid 18855623 doi 10.2174 138945008785909356 url http www.bentham direct.org pages content.php?CDT 2008 00000009 00000010 0009J.SGM ref Neutral endopeptidase NEP ref name pmid18855623 Dipeptidyl peptidase 3 DPP3 ref name pmid18855623 Carboxypeptidase A6 CPA6 ref name pmid18178555 cite journal author Lyons PJ, Callaway MB, Fricker LD title Characterization of carboxypeptidase A6, an extracellular matrix peptidase journal The Journal of Biological Chemistry volume 283 issue 11 pages 7054 63 year 2008 month March pmid 18178555 doi 10.1074 jbc.M707680200 url http www.jbc.org cgi pmidlookup?view long&pmid 18178555 ref Angiotensin converting enzyme ACE ref name pmid20487892 cite journal author Benuck M, Berg MJ, Marks N title Separate metabolic pathways for Leu enkephalin and Met enkephalin Arg 6 Phe 7 degradation by rat striatal synaptosomal membranes journal Neurochemistry International volume 4 issue 5 pages 389 96 year 1982 pmid 20487892 doi 10.1016 0197 0186 82 90081 X url http linkinghub.elsevier.com retrieve pii 0197 0186 82 90081 X ref See also Enkephalinase inhibitor Enkephalin References Reflist Proteases Opioids Category Hydrolases Category Human proteins Category Nociception ... more details
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