Orphan date July 2010 Primary sources date August 2010 The Tanz Centre for Research in Neurodegenerative Diseases Tanz CRND is a research institute at the University of Toronto , under the umbrella of the University of Toronto Faculty of Medicine Faculty of Medicine , with a focus on the spectrum of neurodegenerative diseases . The Tanz CRND has made a number of important contributions to research in neurodegenerative diseases, particularly on Alzheimer s disease. The association of late onset Alzheimer s disease with the Epsilon 4 allele of apolipoprotein E was co discovered there in conjunction with Duke University in a team led by Allen Roses. Two of the genes associated with most aggressive forms of Alzheimer s disease , namely presenilin 1 and presenilin 2 were discovered there. In addition, a robust model organism for the amyloid pathology of Alzheimer s disease was created there. The Tanz CRND have also contributed to knowledge about candidate therapies for Alzheimer s disease that are currently under investigation, including amyloid vaccines and scyllo inositol. The Tanz CRND was established in 1990 via philanthropic support from the Alzheimer Society of Ontario , a group of private individuals led by Drs. Mark Tanz and Lionel Schipper. The Tanz Centre for Research in Neurodegeneration is currently located at the Tanz Neuroscience Building on the St. George campus of the University of Toronto. The founding director of the institute was Professor Donald Crapper McLachlan, and is currently directed by Professor Peter St George Hyslop . See also Alzheimer Society of Ontario References Reflist External links http crnd.med.utoronto.ca Tanz Centre for Research in Neurodegenerative Diseases Categories Coord 43.6604 N 79.3920 W display title DEFAULTSORT Centre For Research In Neurodegenerative Diseases Category Neuroscience research centers Category Medical research institutes Category Research institutes in Canada Category 1990 establishments in Canada Category University ... more details
Infobox government agency agency name German Center for Neurodegenerative Diseases nativename Deutsches Zentrum f r Neurodegenerative Erkrankungen logo logo width logo caption seal seal width seal caption picture picture width picture caption formed Start date 2009 headquarters Holbeinstra e 13 15, 53175 Bonn , Germany latd 50 latm 42 lats 4.3092 latNS N longd 7 longm 8 longs 22.059 longEW E region code DE coordinates employees budget chief1 name Prof. Pierluigi Nicotera chief1 position Scientific Director chief2 name Ursula Weyrich chief2 position Administrative Director agency type website URL www.dzne.de footnotes map map width map caption The German Center for Neurodegenerative Diseases German language German Deutsches Zentrum f r Neurodegenerative Erkrankungen is a newly established Center of Excellence in patient care and research for neurodegenerative diseases. It is affiliated with the University of Bonn and will have its seat on the University Hospital Bonn site. Category University of Bonn Category Organisations based in Bonn Category Medical research institutes NorthRhineWestphalia struct stub de Deutsches Zentrum f r Neurodegenerative Erkrankungen ... more details
Refimprove date February 2012 Infobox television episode Title The Disease Image File ST VOY The Disease.jpg 270px Caption Harry Kim becomes intimate with Varro scientist Tal. Series Star Trek Voyager Season 5 Episode 17 Production 210 Airdate Startdate 1999 02 24 Teleplay Michael Taylor screenwriter Michael Taylor Story Kenneth Biller Director David Livingston director David Livingston Music Dennis McCarthy composer Dennis McCarthy Guests Musetta Vander Tal Charles Rocket Jippeq Prev Dark Frontier Next Course Oblivion Star Trek Voyager Course Oblivion Episode list List of Star Trek Voyager episodes List of Star Trek Voyager episodes NOTOC for an abnormal condition affecting the body of an organism Disease The Disease is the 111th episode of Star Trek Voyager , the 17th episode of the fifth season. The episode had an average rating of 4.2 5 on the official Star Trek website as of August 23, 2007 . ref cite web publisher StarTrek.com url http www.startrek.com startrek view series VOY episode 104851.html title The Disease accessdate 2007 08 23 ref Plot Voyager stops to assist a xenophobic species known as the Varro. This species lives on a Generation ship generational ship which has housed them for 400 years. While the crew works on the Varro ship, Voyager is infested with synthetic ship eating parasites that had been released on the Varro ship by dissident Varro. Meanwhile, Harry Kim Star Trek Harry Kim becomes intimate with Varro scientist Tal, and develops a physiological bond with her, one that is standard in the Varro. The physiological connection alters his behavior and sways him from his duties aboard Voyager . It is later revealed that Tal is one of the separatists. There has been a rumour of a minority of Varro that want off the ship. The parasites that Tal helped create were made to separate the individual pods of the Varro ship without destroying the ship itself ... Star Trek DEFAULTSORT Disease, The Category Star Trek Voyager episodes Category 1999 television episodes ... more details
mergeto Neurodegeneration discuss Talk Neurodegeneration Merger proposal date January 2012 Refimprove date December 2009 A degenerative disease , also called neurodegenerative disease, is a disease in which the function or structure of the affected biological tissue tissues or Organ anatomy organs will progressively deteriorate over time, whether due to normal bodily wear or lifestyle choices such as exercise or eating habits. ref http www.nlm.nih.gov medlineplus degenerativenervediseases.html Degenerative Nerve Diseases ref Degenerative diseases are often contrasted with infectious diseases . Examples of degenerative diseases Amyotrophic Lateral Sclerosis ALS , a.k.a., Lou Gehrig s Disease Alzheimer s disease Parkinson s Disease Multiple system atrophy Niemann Pick disease Atherosclerosis Progressive supranuclear palsy Cancer Tay Sachs Disease Diabetes Heart Disease Keratoconus Inflammatory bowel disease Inflammatory Bowel Disease IBD Prostatitis arthritis Osteoarthritis Osteoporosis Rheumatoid Arthritis Huntington s Disease Chronic traumatic encephalopathy See also Aging Disease Life extension Neurodegeneration Senescence Progressive disease References Reflist DEFAULTSORT Degenerative Disease Category Diseases and disorders ar ca Malaltia degenerativa es Enfermedad degenerativa fa fr Maladie d g n rative hr Degenerativne bolesti id Penyakit degeneratif ms Penyakit degeneratif nl Degeneratieve ziekte pl Choroby zwyrodnieniowe pt Doen a degenerativa sl Degenerativna bolezen sv Degenerativ sjukdom th zh ... more details
Infobox Disease Name Batten disease Image Caption DiseasesDB 31534 ICD10 ICD10 E 75 4 e 70 ICD9 ICD9 330.1 ICDO OMIM 204200 MedlinePlus eMedicineSubj eMedicineTopic MeshID D009472 Batten disease also known as Spielmeyer Vogt Sj gren Batten disease is a rare, fatal autosomal recessive neurodegenerative ... ceroid lipofuscinosis or NCLs . Although Batten disease is usually regarded as the juvenile form of NCL or type 3 , some physicians use the term Batten disease to describe all forms of NCL. Historically, the NCLs were classified by age of disease onset as infantile NCL INCL , late infantile NCL ... BBA Molecular Basis of Disease Neuronal ceroid lipofuscinoses therapeutic strategies Past, present ... BBA Molecular Basis of Disease Neuronal ceroid lipofuscinoses therapeutic strategies Past, present ... disease, but juvenile NCL, the most prevalent form of Batten disease, has been linked to mutations ... title Juvenile neuronal ceroid lipofuscinosis Batten disease a brief review and update journal Curr ... ref ref name urlScienceDirect Experimental Neurology Moving towards therapies for Juvenile Batten disease ... therapies for Juvenile Batten disease? format work accessdate ref Symptoms Early symptoms of the disorder ... loss of sight, speech and motor skills. Eventually, children with Batten disease become blind, bedridden, and demented. Batten Disease is a life limiting disease life expectancy varies depending on the type or variation. History Batten disease is named after the British pediatrician Frederick ... Heinrich Vogt Vogt Torsten Sj gren Sj gren Batten disease , it is the most common form of a group of disorders called neuronal ceroid lipofuscinosis or NCLs . Although Batten disease is usually regarded as the juvenile form of NCL, some physicians use the term Batten disease to describe all forms of NCL. Inheritance and diagnosis Image autorecessive.svg thumb right Batten disease has an autosomal recessive pattern of inheritance . Batten disease is inherited in an autosomal recessive gene ... more details
Infobox disease Name Liver disease Image Non alcoholic fatty liver disease1.jpg Caption Micrograph of non alcoholic fatty liver disease , demonstrating marked macrovesicular steatosis . Trichrome stain . DiseasesDB ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D008107 Liver disease also called hepatic disease is an umbrella term referring to damage to or disease of the liver . Signs and symptoms The symptoms related to liver dysfunction include both physical signs and a variety ... hepatitis , autoimmunity autoimmune hepatitis or hereditary conditions. Alcoholic liver disease ... fatty liver fatty liver disease , alcoholic hepatitis, and cirrhosis . Analogous terms such as drug induced or toxic liver disease are also used to refer to the range of disorders caused by various drugs and environmental chemicals. Fatty liver disease hepatic steatosis is a reversible condition ... disease is a spectrum of disease associated with obesity and metabolic syndrome , among other causes. Fatty liver may lead to inflammatory disease i.e. steatohepatitis and, eventually, cirrhosis. Cirrhosis .... Primary biliary cirrhosis is a serious autoimmune disease of the bile canaliculus bile capillaries . Primary sclerosing cholangitis is a serious chronic inflammation inflammatory disease of the bile .... Hereditary disease s that cause damage to the liver include hemochromatosis , involving accumulation of iron in the body, and Wilson s disease , which causes the body to retain copper . Liver damage is also a clinical feature of alpha 1 antitrypsin deficiency and glycogen storage disease type II ... which has severe neurodegenerative and or cardiopathic effects. Liver transplantation can provide ... in about 5 of the population, can cause mild jaundice . There are also many pediatric liver disease ... of digestive system DEFAULTSORT Liver Disease Category Diseases of liver Category Hepatology fa it Epatopatia kn simple Liver disease ur ... more details
Infobox disease Name Refsum disease Image Phytanic acid.png Caption Phytanic acid DiseasesDB 11213 ICD10 ICD10 G 60 1 g 60 ICD9 ICD9 356.3 ICDO OMIM 266500 MedlinePlus eMedicineSubj derm eMedicineTopic 705 MeshID D012035 Refsum disease , also known as classic or adult Refsum disease, heredopathia atactica polyneuritiformis, phytanic acid oxidase deficiency and phytanic acid storage disease, ref name omim OMIM 266500 ref ref name Fitz2 cite book author Freedberg, et al. year 2003 title Fitzpatrick s Dermatology in General Medicine 6th ed. publisher McGraw Hill isbn 0071380760 page 499 ref ref name ... neurological disease that results from the over accumulation of phytanic acid in cells and tissues ... 1 303 year 1946 ref Classification Adult Refsum disease may be divided into the adult Refsum disease 1 and adult Refsum disease 2 subtypes. The former stems from mutations in the phytanoyl CoA hydroxylase ... omim Adult Refsum disease should not be confused with infantile Refsum disease , a peroxisome biogenesis ... ref Characteristics Individuals with Refsum disease present with neurologic damage, cerebellar ... Refsum disease is a peroxisomal disorder caused by the impaired alpha oxidation of branched chain fatty ... be due to deficiencies of phytanoyl CoA hydroxylase or peroxin 7 activity. In general, Refsum disease is caused by PHYH mutations. Treatment Individuals with Refsum disease are commonly placed on a phytanic ... Storage Disease, Heredopathia Atactica Polyneuritiformis Internet url http www.ninds.nih.gov disorders .... year 2010 title The effectiveness of long term dietary therapy in the treatment of adult Refsum disease ... of Refsum s disease journal J. Pharmacol. Exp. Ther. volume 318 issue 2 pages 835 9 year 2006 pmid 16707724 ... br.fcgi?book gene&part refsum GeneReview NCBI NIH UW entry on Refsum Disease References Reflist 2 PNS diseases of the nervous system Peroxisomal disorders DEFAULTSORT Refsum s Disease Category Peroxisomal disorders Category Autosomal recessive disorders Category Genodermatoses Category Neurodegenerative ... more details
distinguish Niemann Pick disease Infobox Disease Name Pick& 39 s disease Image Pick s disease.png Caption Brain MRI in Pick s disease DiseasesDB 10034 ICD10 ICD10 G 31 0 g 30 , ICD10 F 02 0 f 00 ICD9 ICD9 331.11 ICDO OMIM 172700 MedlinePlus eMedicineSubj neuro eMedicineTopic 311 MeshID D020774 Pick s disease is a rare neurodegenerativedisease that causes progressive destruction of nerve cells in the brain ... literature that classical Pick s disease pathology can run in families or has a genetic cause. Pathophysiology PiD was first recognized as a distinct disease separate from other neurodegenerative diseases ... be alleviated, the disease progresses and patients often die within two to ten years. ref name Medline http www.nlm.nih.gov medlineplus ency article 000744.htm Pick s Disease Medline Plus Medical Encyclopedia, retrieved 2011 April 30 ref A defining characteristic of the disease is build up of tau ... s disease with Pick bodies combined with progressive supranuclear palsy without tuft shaped astrocytes ... the term Pick s disease was once used to represent a class of clinical syndromes with symptoms attributable ... still use the term Pick s disease to mean the more general clinical syndrome of frontotemporal lobar ... as Pick disease and PiD not to be confused with Pelvic Inflammatory Disease PID or Parkinson s Disease PD . Signs and symptoms The symptoms of Pick s disease include difficulty in speech and thinking ... between Pick s disease and Alzheimer s disease. ref name Medline Pick s disease is one .... Pick s disease pathology is associated more with the frontotemporal dementia and progressive nonfluent ... universally present in patients with PiD, but some new cases of atypical Pick s disease have come ... and biochemical studies on a case of Pick disease with severe white matter atrophy journal Neuropathology ... lesions of Pick s disease journal Neuropathology volume 18 issue 4 pages 295 300 year 1998 pmid doi ... body disease and Pick syndrome journal Neuropathology volume 23 issue 4 pages 318 326 year 2003 pmid ... more details
1189 91 journal Klin Wochenschr ref ref name omim OMIM 268800 Sandhoff Disease ref neurodegenerative disorder is clinically almost indistinguishable from Tay Sachs disease , another genetic disorder that disrupts beta hexosaminidases A and S. There are three subsets of Sandhoff disease based on when first symptoms appear classic infantile, juvenile and adult late onset. History Sandhoff disease is one of several forms of what was formerly known as amaurotic idiocy. This inherited disease is characterized ...Infobox Disease Name Sandhoff disease Image Caption DiseasesDB 29469 ICD10 ICD10 E 75 0 e 70 ICD9 ICD9 330.1 ICDO OMIM 268800 MedlinePlus eMedicineSubj eMedicineTopic MeshID D012497 Sandhoff disease , also known as Sandhoff Jatzkewitz disease , variant 0 of GM2 Gangliosidosis or Hexosaminidase A and B ... case of Tay Sachs disease with additional storage of kidney globoside in visceral organs volume ... pattern in Tay Sachs disease volume 4 issue 4 pages 351 354 journal FEBS Lett doi 10.1016 0014 ... Biochim Biophys Acta ref , Sandhoff disease in 1968 ref name KS , Tay Sachs Disease ref name KS2 ref cite journal pmid 5793973 year 1969 month August author Okada S, O Brien JS title Tay Sachs disease ... defect in Sandhoff disease, when Konrad Sandhoff studied the biochemistry of sphingolipids and gangliosides ..., and different from all cases of Tay Sachs disease studied so far, globoside accumulated in the visceral organs and, most importantly, hexosaminidase activity was almost completely absent. The disease ... different types of Sandhoff disease, classic infantile, juvenile, and adult late onset ref ... in infantile Sandhoff disease volume 3 issue 1 pages 139 145 journal Human Molecular Genetics doi 10.1093 hmg 3.1.139 pmid 8162015 ref Classic infantile form of the disease is classified by the development ... publisher Parents of Children whom are living or whom have lived with Sandhoff Disease title What is Sandhoff Disease from a medical perspective url http sandhoffdisease.webs.com parentsperspective.htm ... more details
Infobox disease Name Alexander disease Image Caption DiseasesDB ICD10 ICD9 ICD9 331.89 ICDO OMIM 203450 MedlinePlus eMedicineSubj eMedicineTopic MeshID D038261 Alexander disease is a slowly progressing and fatal neurodegenerativedisease . It is a very rare disorder which results from a genetic mutation .... ref http www.highbeam.com doc 1P1 38896449.html MUTATION KEY TO ALEXANDER DISEASE United ... alexander Alexander Disease Gene Reviews ref ref name NINDS Clinical features Delays in development ... Alexander disease is a genetic disorder affecting the central nervous system midbrain and cerebellum ... of a parent with the disease has a 50 50 chance of inheriting the condition ref name Gene Alexander disease belongs to leukodystrophies , a group of diseases which affect growth or development of the myelin ... disorders alexander disease alexander disease.htm ref ref name BBC http news.bbc.co.uk 2 hi health 1097277.stm Cause of brain disease found BBC News ref Rosenthal fibers appear not to be present ... forms of cancer . ref name NINDS ref name Alexander The Rosenthal fibers found in Alexander disease ... The cause of Alexander disease is a mutation in the gene encoding glial fibrillary acidic protein ... HWFIG Can MR Imaging Diagnose Adult Onset Alexander Disease? AJNR ref Diagnosis It is possible to detect the signs of Alexander disease with Magnetic Resonance Imaging, which looks for specific changes in the brain that may be tell tale signs for the disease. ref name Alexander ref http www.ajnr.org ... 3470&resourcetype HWCIT Alexander Disease Diagnosis with MR Imaging AJNR ref It is even possible to detect adult onset Alexander disease with MR imaging. ref name Adult Alexander disease may also be revealed by genetic testing for the known cause of Alexander disease. ref name Alexander http www.ulf.org ... bmt journal v20 n3 abs 1700871a.html Allogeneic bone marrow transplantation for Alexander s disease ... 10 years after the onset of symptoms. Usually, the later the disease occurs, the slower its course ... more details
wiktionary disease A disease is an abnormal condition of an organism that impairs bodily functions and can be deadly. Disease may also refer to Disease album Disease album , a 1993 album by G.G.F.H. Disease song Disease song , a 2002 song by Matchbox Twenty disambiguation ... more details
article 289706 MeshID D006816 Huntington s disease HD is a neurodegenerativediseaseneurodegenerative ... neurodegenerativedisease journal Nat. Neurosci. volume 10 issue 11 pages 1355 60 year 2007 ... Repeats Associated with NeurodegenerativeDisease JBC cite web url http www.jbc.org content 273 ... Associated with NeurodegenerativeDisease JBC work accessdate ref Specifically, CRB contains a acetyltransferase ... with NeurodegenerativeDisease JBC Plus, when CBP is overexpressed, polyglutamine induced death ...Infobox disease Name Huntington s disease Image Neuron with mHtt inclusion.jpg Alt Several neurons coloured ... , which occur as part of the disease process, image width 360 micrometre m DiseasesDB 6060 ... genetic cause of abnormal involuntary writhing movements called chorea , and indeed the disease ... than in those of Asian or African ancestry. The disease is caused by an Autosome autosomal Dominance ... means any child of an affected parent has a 50 risk of inheriting the disease. Physical symptoms of Huntington s disease can begin at any age from infancy to old age, but usually begin between 35 and 44 years of age. Through anticipation genetics genetic anticipation , the disease may develop ... in 1993 by an international collaborative effort spearheaded by the Hereditary Disease Foundation ... genetics genetically dominant diseases. Symptoms of the disease can vary between individuals and even ... often follows. As the disease advances, uncoordinated, jerky body movements become more apparent ... generally decline into dementia . Complications such as pneumonia , heart disease , and physical ... for HD, and full time care is required in the later stages of the disease. Existing pharmaceutical ... research discoveries have been made and understanding of the disease is improving. Current research directions include determining the exact mechanism of the disease, improving animal models to expedite research, clinical trials of pharmaceuticals to treat symptoms or slow the progression of the disease ... more details
A polycystic disease is a disease that involves multiple cysts scattered throughout an organ, including Polycystic kidney disease Polycystic liver disease Polycystic ovary syndrome disambig ... more details
Artery disease may refer to the following coronary artery disease Peripheral artery disease, more commonly called peripheral vascular disease Carotid artery disease, more commonly called carotid artery stenosis disambig ... more details
Disease management may refer to Disease management agriculture Disease management health disambig Long comment to avoid being listed on short pages ... more details
Sir James Paget , a surgeon and pathologist, described several diseases, including Paget s disease of bone most common use of Paget s disease Paget s disease of the breast Paget Schroetter disease Extramammary Paget s disease EMPD disambig ar sl Pagetova bolezen ... more details
Charcot disease can refer to several diseases named for Jean Martin Charcot , such as Amyotrophic lateral sclerosis , a degenerative muscle disease also known as Charcot disease or Lou Gehrig s disease Charcot Marie Tooth disease , an inherited demyelinating disease of the peripheral nervous system Neuropathic arthropathy , progressive degeneration of a weight bearing joint, also known as Charcot joint disease or Charcot arthropathy disambig ... more details
Still s disease can refer to Juvenile idiopathic arthritis Adult onset Still s disease disambig DEFAULTSORT Still S diSeaSe Category Connective tissue diseases pt Doen a de Still fr Maladie de Still ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D005882 A gingival disease is a disorder primarily affecting the gingiva . An example is gingivitis . disease stub Oral pathology Periodontology Category Periodontal disorders ... more details
Duroziez s disease is a congenital variant of mitral stenosis . It was described in 1877 by Paul Louis Duroziez . External links WhoNamedIt synd 2735 Duroziez disease Congenital heart defects Category Heart diseases disease stub ... more details
syndrome , Systemic lupus erythematosus lupus , Crohn s disease or other autoimmune and neurodegenerative ...Infobox disease Name Lyme disease Image Adult deer tick.jpg Caption Nymphal and adult Ixodes scapularis deer tick s can be carriers of Lyme disease. Nymphs are about the size of a poppy seed. DiseasesDB ... 330178 eMedicine mult eMedicine2 article 965922 eMedicine2 article 786767 MeshID D008193 Lyme disease ... edition 2nd ref is an emerging infectious disease caused by at least three species of bacteria belonging ... Manifestations of Lyme Disease in Adults title UpToDate publisher UpToDate year 2009 url http www.uptodate.com contents clinical manifestations of lyme disease in adults ref is the main cause of Lyme disease in the United States , whereas Borrelia afzelii and Borrelia garinii cause most Europe an cases. The disease is named after the town of Lyme, Connecticut , USA, where a number of cases were identified in 1975. Although Allen Steere realized that Lyme disease was a tick borne disease in 1978, the cause of the disease remained a mystery until 1981, when B. burgdorferi was identified by Willy Burgdorfer . Lyme disease is the most common tick borne disease in the Northern Hemisphere . citation ... Lyme disease can affect multiple body systems and produce a range of symptoms. Not all patients with Lyme disease will have all symptoms, and many of the symptoms are not specific to Lyme disease ... for most cases. ref EMedicine article 330178 Lyme disease ref Asymptomatic infection exists ... ref Early localized infection Image Bullseye Lyme Disease Rash.jpg thumb Common bullseye rash pattern associated with Lyme disease Image Erythema migrans erythematous rash in Lyme disease PHIL ... of early local infection with Lyme disease is a circular, outwardly expanding rash called erythema ... days after the tick bite. ref EMedicine article 1202521 Ophthalmic Aspects of Lyme Disease Overview of Lyme Disease ref ref name isbn0 07 159991 6 cite journal author Steere, AC year 2008 chapter ... more details
Infobox Disease Name Fetal disease Image Caption DiseasesDB ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D005315 Fetal disease refers to disorders originating in utero . Examples include hydrops fetalis and chorioamnionitis Medical conditions Certain conditions originating in the perinatal period Category Disorders originating in the perinatal period disease stub ... more details
Disease reservoir may refer to Natural reservoir , the long term host of the pathogen of an infectious disease Fomite , any inanimate object or substance capable of carrying infectious organisms Disambig ... more details
Infobox disease Name Tooth disease Image Caption DiseasesDB ICD10 K00 K05 ICD9 ICD9 520 ICD9 525 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D014076 A tooth disease is a disorder of the tooth that can be congenital or acquired. Examples Expand section date August 2011 Congenital anodontia Acquired dental caries Medical conditions Tooth disease Category Dental disorders disease stub ... more details
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