Nuclear ambiguity can mean neither confirming nor denying possession of nuclear weapons, see Nuclear weapons and Israel problem that launching an attack with a conventional weapon can be mistaken for a nuclear attack, see Prompt Global Strike disamb ... more details
Gene Johnson may refer to Gene Johnson American football 1935 1997 , American football player Gene Johnson athlete born 1941 , American high jumper Gene Johnson basketball 1902 1989 , American basketball coach Gene Johnson virologist , American virologist hndis name Johnson, Gene ... more details
File Gene therapy.jpg thumb 300px Gene therapy using an Adenovirus vector. A new gene is inserted into an adenovirus. If the treatment is successful, the new gene will make functional protein to treat a disease. Gene therapy is the use of DNA as a pharmaceutical agent to treat disease. It derives its name from the idea that DNA can be used to supplement or alter gene s within an individual s Cell biology cells as a therapy to treat disease . The most common form of gene therapy involves using DNA that encodes a functional, therapeutic gene in order to replace a mutate d gene. Other forms involve ... human gene to provide treatment. In gene therapy, DNA that encodes a therapeutic protein is packaged ..., which in turn treats the patient s disease. Gene therapy was first conceptualized in 1972, with the authors urging caution before commencing gene therapy studies in humans. ref name Friedman 1972 The first FDA approved gene therapy experiment in the United States occurred in 1990, when Ashanti DeSilva was treated for ADA SCID. ref name Gene Therapy Finds Its Niche Sheridan, C. 2011 . Gene therapy ... ref Since then, over 1,700 clinical trials have been conducted using a number of techniques for gene therapy. ref name JGenMed Database J. Gene Med. Gene Therapy Clinical Trials Database. http www.wiley.com ... gene therapy as over hyped, clinical successes in 2009 2011 have bolstered new optimism in the promise of gene therapy. These include successful treatment of patients with the retinal disease Leber s Congenital ... of gene therapy for SCID. Nature Immunology 11, 457 2010 . doi 10.1038 ni0610 457 ref Severe combined immunodeficiency ADA SCID , ref Ferrua F. et al. , Update on gene therapy for adenosine deaminase ... adrenoleukodystrophy , ref Hematopoietic Stem Cell Transplantation and Hematopoietic Stem Cell Gene ...., Flaherty, A. W., Eskandar, E. N., Kostyk, S. K., et al. 2011 . AAV2 GAD gene therapy for advanced ... interest in gene therapy, with several articles in scientific and popular publications calling ... more details
Aanta, M.A., Belguise Valladier, P., Behr, J.P. Gene delivery a single nuclear localization signal ...Image Computational Gene.jpg thumb 225px right Figure 1 Design of a computational gene Context date October 2009 A computational gene ref Martinez Perez, I.M., Zhang, G., Ignatova, Z., Zimmermann, K. H. Computational genes a tool for molecular diagnosis and therapy of aberrant mutational phenotype. BMC Bioinformatics , 8 365, 2007. http www.biomedcentral.com 1471 2105 8 365 ref ref Zimmermann, K. H ... work in a cellular environment. The structural part is a naturally occurring gene , which ... features of a structural gene e.g., DNA polymerase binding site, start and stop codons , and splicing sites serve as constants of the computational gene, while the coding regions, the number of exons ..., states, and transitions are the design parameters of the computational gene. The constants and the design ... e.g., carcinogenic molecular phenotype and turn on the self assembly of the functional gene. If the input is accepted, the output encodes a double stranded DNA dsDNA molecule, a functional gene which ... to correct aberrant mutations in a gene or group of genes that can trigger disease phenotypes ... is the tumor suppressor p53 gene, which is present in every cell, and acts as a guard to control the growth. Mutations in this gene can abolish its function, allowing uncontrolled growth that can lead to cancer ref Montesano, R., Hainaut, P., Wild, C.P. Hepatocellular carcinoma from gene to public ... switch for the linear self assembly of the functional gene Fig. 2 . The gene structure is completed ... genes combine the techniques of gene therapy which allows to replace in the genome an aberrant gene by its healthy counterpart, as well as to silence the gene expression similar to antisense technology ... 1& urlVersion 0& userid 10&md5 3269768940ce7a2de47ca34fc59065df ref . Some results show that nuclear ... biology and nucleic acid chemistry Matagen masking tape for gene expression . Anticancer Drug Res ... more details
Gene Moore may refer to Gene Moore pitcher 1885 1938 , Major League Baseball pitcher Gene Moore outfielder 1909 1978 , Major League Baseball outfielder Gene Moore basketball 1945 , American Basketball Association player Gene Moore window dresser 1910 1998 , store window dresser hndis name Moore, Gene DEFAULTSORT Moore, Gene it Gene Moore ... more details
About the supercomputer the musician Blue Gene Tyranny cleanup rewrite date December 2011 Image IBM Blue Gene P supercomputer.jpg right thumb A Blue Gene P supercomputer at Argonne National Laboratory Blue Gene is an IBM project aimed at designing supercomputers that can reach operating speeds in the FLOPS ..., Blue Gene L, Blue Gene P, and Blue Gene Q. Blue Gene systems have led for several years ... journal url http www.research.ibm.com journal sj 402 allen.pdf title Blue Gene A Vision for Protein ... machine architectures. The initial design for Blue Gene was based on an early version of the Cyclops64 ... of this system and it became known as Blue Gene L L for Light development of the original Blue Gene system continued under the name Blue Gene C C for Cyclops and, later, Cyclops64 . In November 2001, Lawrence Livermore National Laboratory LLNL joined IBM as a research partner for Blue Gene. Development ... to LLNL Blue Gene L Image BlueGeneL cabinet.jpg right thumb A Blue Gene L cabinet Image Blue Gene L ASIC.png thumb left The block scheme of the Blue Gene L ASIC including dual PowerPC 440 cores .... From 2004 through 2007 the Blue Gene L installation at LLNL ref cite web url http asc.llnl.gov computing ... system to surpass the 1 PetaFLOPS mark. While the LLNL installation was the largest Blue Gene L ... list using the Blue Gene L architecture. All these computers were listed as having an architecture of eServer Blue Gene Solution . For example, three racks of Blue Gene L were housed at the San ..., Linpack , Blue Gene L also set records for performance on a wider set of applications. Blue Gene ... won the 2005 Gordon Bell Prize . In June 2006, NNSA and IBM announced that Blue Gene L achieved 207.3 ... ref At Supercomputing 2006, ref http sc06.supercomputing.org SC06 ref Blue Gene L was awarded the winning ... The Blue Gene L supercomputer was unique in the following aspects ref cite journal url http www.research.ibm.com journal rd49 23.html journal IBM Journal of Research and Development title Blue Gene ... more details
The entry and exit of large molecules from the cell nucleus is tightly controlled by the nuclear pore complex es NPCs . Although small molecules can enter the nucleus without regulation, ref name Watson cite book last Watson first JD coauthors Baker TA, Bell SP, Gann A, Levine M, Losick R. title Molecular Biology of the Gene publisher Peason Benjamin Cummings CSHL Press. date 2004 edition 5th chapter Ch9 10 isbn 0805396039 ref macromolecules such as RNA and proteins require association with karyopherin s called importin s to enter the nucleus and exportin s to exit. Protein that must be imported to the nucleus from the cytoplasm carry nuclear localization signal s NLS that are bound by importins. A NLS is a sequence of amino acids that acts as a tag. They are diverse in their composition and most commonly hydrophilic , although hydrophobic sequences have also been documented. ref name Watson ... due to association with exportins, which bind signaling sequences called nuclear export signal s NES ... s, such as RNA and protein s, are active transport actively transported across the nuclear membrane in a process called the Ran biology Ran Guanosine triphosphate GTP nuclear transport cycle. Nuclear import Importin proteins bind their cargo in the cytoplasm, after which they are able to interact with the nuclear ... 4 351 64. ref The Ran GDP produced from this process now binds the nuclear transport factor NUTF2 which ... GTP, and beginning the cycle anew. Nuclear export Nuclear export roughly reverses the import process ... Bryce M. Paschal title Mechanisms of Receptor Mediated Nuclear Import and Nuclear Export journal Traffic .... Some particularly commonly transcribed genes are physically located near nuclear pores to facilitate ... nuclearporecomplex Nuclear Transport animations http sspatel.googlepages.com nuclearporecomplex2 Nuclear Transport illustrations Category Cell biology ca Transport nuclear pt Transporte nuclear zh ... more details
Gene Smith may refer to Gene Smith American football , current general manager for the Jacksonville Jaguars Gene Smith athletic director , current athletic director at the Ohio State University Gene Smith Negro leagues pitcher 1917 2011 , Negro league baseball player Gene Ward Smith , mathematician, composer, and music theorist E. Gene Smith 1936 2010 , scholar of Tibetology W. Eugene Smith American photojournalist See also Eugene Smith disambiguation hndis Smith, Gene ... more details
refimprove date December 2010 Infobox person image occupation Television actor website http www.voicegene.com Eugene B. Gene Galusha 20 August 1941 6 August 2008 ref cite web url http www.legacy.com TimesUnion Albany Obituaries.asp?Page LifeStory&PersonId 115264547 title Eugene B. Gene Galusha date 2008 08 10 work legacy.com accessdate 2008 09 06 ref was a part time Jewish actor and full time narrator who has worked for Public Broadcasting Service PBS , ESPN , Court TV , Discovery Channel , A&E Network A&E , American Broadcasting Company ABC , TLC TV channel The Learning Channel and NFL Films . His credits include As actor Stephanie Daley 2006 in film 2006 film Mr. Gilchrist The West Wing TV series The West Wing Particular Men 1972 . As narrator Evening at Pops Frontline US TV series Frontline The Investigators The New Detectives Case Studies in Forensic Science , ref http scholar.lib.vt.edu VA news VA Pilot issues 1996 vp960607 06070072.htm The Virginian Pilot DETECTIVES ENLIGHTENING, BUT NOT FUN , June 7, 1996 ref National Geographic Explorer Nova TV series Nova Masterpiece Theatre Mystery The Rockefeller Family and Colonial Williamsburg War and Peace in the Nuclear Age 1989 Iceland River Challenge Forensic Detectives . The Longest Hatred A Revealing History of Anti Semitism 1991 Galusha died of an unspecified illness on August 6, 2008 he was 66 years old. ref Last Name , First Initials . 2008, August 10 . Galusha, Eugene B. Gene . Times Union, The Albany, NY 1 ed. , D5. Retrieved May 23, 2011, from NewsBank on line database Access World News ref References Reflist External links IMDb name 0303384 http www.voicegene.com Official site Persondata Metadata see Wikipedia Persondata . NAME Galusha, Gene ALTERNATIVE NAMES SHORT DESCRIPTION American actor DATE OF BIRTH 20 August 1941 PLACE OF BIRTH DATE OF DEATH 6 August 2008 PLACE OF DEATH DEFAULTSORT Galusha, Gene Category American voice actors Category 1941 births Category 2008 deaths US tv actor stub ... more details
SJ title The human dUTPase gene encodes both nuclear and mitochondrial isoforms. Differential ... title Entrez Gene DUT dUTP pyrophosphatase url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... author Ladner RD, McNulty DE, Carr SA, et al. title Characterization of distinct nuclear and mitochondrial ... phosphorylation site unique to the nuclear form of human deoxyuridine triphosphate nucleotidohydrolase ... cite journal author Cohen D, Heng HH, Shi XM, et al. title Assignment of the human dUTPase gene DUT ..., et al. title Novel gain of function activity of p53 mutants activation of the dUTPase gene expression ... FJ, Ladner RD title Identification of sequence determinants of human nuclear dUTPase isoform localization ..., quality, and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC . journal ... pages 306 10 year 2005 pmid 15629463 doi 10.1016 j.bbrc.2004.12.021 refend PDB Gallery geneid 1854 gene ... more details
Expert subject Physics date February 2009 Nuclear data groups all experimental data relevant for nuclear physics and nuclear applications . It includes a large and non exhaustic number of physical quantities, like scattering and reaction cross section physics cross sections which can also be measured as functions of e.g. the energy and the angle , nuclear structure and nuclear decay parameters, etc. It can involve neutron s, proton s, deuteron s, alpha particle s, and virtually all isotope nuclear isotope s which can be handled in a laboratory . There are two major reasons to need high quality nuclear data theoretical model development of nuclear physics , and applications involving radiation and nuclear power . There is often an interplay between these two aspects, since applications often motivate research in particular theoretical fields, and theory can be used to predict quantities or phenomena which can lead to new or improved technological concepts. See also Nuclear reaction Nuclear force External links http www.nndc.bnl.gov National Nuclear Data Center Brookhaven National Laboratory http www nds.iaea.org IAEA Nuclear Data Centre Nuclear Data Services Category Nuclear physics Data, nuclear ar ... more details
NRF in basal repression of the hiNOS gene. journal Proc. Natl. Acad. Sci. U.S.A. volume 99 issue 22 ... cDNA project the Mammalian Gene Collection MGC . journal Genome Res. volume 14 issue 10B pages 2121 ... NFkappaB kinetics in MMP 9 gene expression and chemoresistance to 5 fluorouracil in RKO colorectal ... 40 year 2007 pmid 17592041 doi 10.1261 rna.545407 pmc 1924892 refend gene X stub The PBB Controls ... more details
assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA ... 3.pdf format PDF ref ref name entrez cite web title Entrez Gene CMAS cytidine monophosphate N acetylneuraminic ... encoded by this gene catalyzes the activation of Neu5Ac to Cytidine 5 prime monophosphate N acetylneuraminic ... that this protein localizes to the nucleus. ref name entrez cite web title Entrez Gene CMAS cytidine ... method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. journal Gene ... gene discovery. journal Genome Res. volume 6 issue 9 pages 791 806 year 1997 pmid 8889548 doi ... Gene volume 200 issue 1 2 pages 149 56 year 1997 pmid 9373149 doi 10.1016 S0378 1119 97 00411 3 cite ... acetylneuraminic acid synthetase a nuclear protein with evolutionarily conserved structural motifs. journal ... Nuclear localization signal of murine CMP Neu5Ac synthetase includes residues required for both nuclear ... Amin AN, et al. title NotI flanking sequences a tool for gene discovery and verification of the human ... the Mammalian Gene Collection MGC . journal Genome Res. volume 14 issue 10B pages 2121 7 year 2004 pmid 15489334 doi 10.1101 gr.2596504 pmc 528928 refend PDB Gallery geneid 55907 gene 12 stub The PBB ... more details
Gene Roberts may refer to Gene Roberts journalist born 1932 , American editor and professor of journalism Gene Roberts American football 1923 2009 , former NFL running back Meg Randall born 1926 , American actress, credited as Gene Roberts before 1949 Gene Roberts, former List of mayors of Chattanooga, Tennessee mayor of Chattanooga, Tennessee hndis Roberts, Gene ... more details
Orphan date February 2009 PBB geneid 4931 Nuclear valosin containing protein like is a protein that in humans is encoded by the NVL gene . ref name pmid9286697 cite journal author Germain Lee EL, Obie C, Valle D title NVL a new member of the AAA family of ATPases localized to the nucleus journal Genomics volume 44 issue 1 pages 22 34 year 1997 month Nov pmid 9286697 pmc doi 10.1006 geno.1997.4856 ref ref name entrez cite web title Entrez Gene NVL nuclear VCP like url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 4931 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Nagahama M, Yamazoe T, Hara Y, et al. title The AAA ATPase NVL2 is a component of pre ribosomal particles that interacts with the DExD H box RNA helicase DOB1. journal Biochem. Biophys. Res. Commun. volume 346 issue 3 pages 1075 82 year 2006 pmid 16782053 doi 10.1016 j.bbrc.2006.06.017 cite journal author Gerhard DS, Wagner L, Feingold EA, et al. title The Status, Quality, and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC journal Genome Res. volume 14 issue 10B pages 2121 7 year 2004 pmid 15489334 doi 10.1101 gr.2596504 pmc 528928 cite journal author Nagahama M, Hara Y, Seki A, et al. title NVL2 Is a Nucleolar AAA ATPase that Interacts with Ribosomal Protein L5 through Its Nucleolar Localization Sequence journal Mol. Biol. Cell volume 15 issue 12 pages 5712 23 year 2005 pmid 15469983 doi 10.1091 mbc.E04 08 0692 pmc 532049 cite journal author Leonard D, Ajuh P, Lamond AI, Legerski RJ title hLodestar HuF2 interacts with CDC5L and is involved ... MF, Lennon G, Soares MB title Normalization and subtraction two approaches to facilitate gene discovery ... refend gene 1 stub The PBB Controls template provides controls for Protein Box Bot, please see ... more details
, McKay JD, Sale MM, et al. title Mutations in a novel gene, NHS, cause the pleiotropic effects of Nance ... of the gene for Nance Horan syndrome NHS journal J. Med. Genet. volume 41 issue 10 pages 768 71 ... A, Murugan S, et al. title Truncating mutation in the NHS gene phenotypic heterogeneity of Nance ... 13 issue pages 470 4 year 2007 pmid 17417607 doi pmc 2647563 refend gene X stub The PBB Controls ... more details
2001 month May. title Protein Interactions of the MLL PHD Fingers Modulate MLL Target Gene Regulation ... al. title A nuclear RNA binding cyclophilin in human T cells journal FEBS Lett. volume 398 issue 2 3 ... M, Bulanova E, et al. title Protein Interactions of the MLL PHD Fingers Modulate MLL Target Gene ... cDNA Project The Mammalian Gene Collection MGC journal Genome Res. volume 14 issue 10B pages 2121 7 ... doi 10.1038 nature04727 refend PDB Gallery geneid 10450 gene 1 stub The PBB Controls template provides ... more details
Gene Callahan may refer to Gene Callahan production designer 1923 1990 , American film and television art director and set decorator who won two Oscars Gene Callahan economist born 1959 , American libertarian economist and writer adjunct scholar with the Ludwig von Mises Institute See also Callahan disambiguation hndis Callahan, Gene ... more details
Gene Washington may refer to Gene Washington 49ers , NFL wide receiver for the San Francisco 49ers. Gene Washington Vikings , NFL wide receiver for the Minnesota Vikings. hndis Washington, Gene ja ... more details
A Nuclear protein is a protein found in the Cell nucleus . ref MeshName Nuclear Proteins ref References reflist External links http npd.hgu.mrc.ac.uk user about Nucleus Category Cell nucleus biochem stub ... more details
PBB geneid 4330 MN1 is a gene found on human Chromosome 22 human chromosome 22 , with gene map locus 22q12.3 qter. ref name pmid7731706 cite journal author Lekanne Deprez RH, Riegman PH, Groen NA, Warringa UL, van Biezen NA, Molijn AC, Bootsma D, de Jong PJ, Menon AG, Kley NA title Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma journal Oncogene volume 10 issue 8 pages 1521 8 year 1995 month April pmid 7731706 doi url issn ref Its official full name is meningioma disrupted in balanced translocation 1 because it is disrupted by a Chromosomal translocation balanced translocation 4 22 in a meningioma . Function MN1 is a transcription coregulator which enhances or represses retinoic acid receptor RAR retinoid X receptor RXR mediated Transcription genetics gene transcription through interaction with nuclear receptor coactivator 3 RAC3 and EP300 p300 . ref name pmid12569362 cite journal author van Wely KH, Molijn AC, Buijs A, Meester Smoor MA, Aarnoudse AJ, Hellemons A, den Besten P, Grosveld GC, Zwarthoff EC title The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR RXR mediated transcription journal Oncogene volume 22 issue 5 pages 699 709 year 2003 month February pmid 12569362 doi 10.1038 sj.onc.1206124 url issn ref MN1 also acts as a coactivator genetics coactivator of the calcitriol ... of the ETS like TEL gene on 12p13 to the MN1 gene on 22q11 journal Oncogene volume 10 issue ... 1895241 cite journal author Schroeder T, Czibere A, Zohren F, et al. title Meningioma 1 gene is differentially ... gene expression. journal Carcinogenesis volume 29 issue 10 pages 2025 34 year 2008 pmid 18632758 ... gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia a cancer ... scale characterization of HeLa cell nuclear phosphoproteins. journal Proc. Natl. Acad. Sci. U.S.A. volume ... results in fusion of the ETS like TEL gene on 12p13 to the MN1 gene on 22q11. journal Oncogene ... more details
Encyclopedia
top
