unreferenced date February 2007 Nucleosidetriphosphate NTP is a molecule containing a nucleoside bound to three phosphate s. Natural nucleoside triphosphates include adenosine triphosphate ATP , guanosine triphosphate GTP , cytidine triphosphate CTP , 5 methyluridine triphosphate m sup 5 sup UTP , and uridine triphosphate UTP . These terms refer to those nucleoside triphosphates that contain ribose. The nucleoside triphosphates containing deoxyribose take prefix deoxy in their names and small d in their abbreviations deoxyadenosine triphosphate dATP , deoxyguanosine triphosphate dGTP , deoxycytidine triphosphate dCTP , deoxythymidine triphosphate dTTP and deoxyuridine triphosphate . Check the entry nucleoside for table and description of these compounds. Apart from d ATP, d GTP, d CTP, d TTP and d UTP, there are other less abundant NTPs, such as intermediates of nucleotide metabolism, but also rare natural nucleotides or even artificial nucleotides . The rare NTP are tautomeric forms of the NTPs. They cause mismatched base pairing during DNA replication. For example, a tautomeric form of cytosine is capable of forming 3 h bonds with adenine, and it will spontaneously revert to its original cytosine form, causing a mismatch. By a similar token, the deamination of cytosine leads to uracil, whereas a deamination of a commonly encountered in eukaryotes 5 methylcytosine will lead to thymine. However, the 5 to 3 DNA replication ensures that these mismatched bases are excised. Nucleotide ..., it is a nucleoside monophosphate NMP . If the nucleotide has two phosphates, then it is called a nucleoside diphosphate NDP , and for three, it is a nucleosidetriphosphate NTP . The nucleotides that contain ... group for phosphorylations. Generally nucleoside s are nucleotide s sugar covalently bonded to a nitrogenous ... phosphorylation , while phosphorylation status of other nucleotides is regulated by Nucleoside diphosphate kinase NDP kinase s http enzyme.expasy.org EC 2.7.4.6 EC 2.7.4.6 and Nucleoside phosphate ... more details
enzyme Name nucleosidetriphosphate adenylate kinase EC number 2.7.4.10 CAS number 9026 74 8 IUBMB EC number 2 7 4 10 GO code 0046899 image width caption Orphan date February 2009 In enzymology , a nucleosidetriphosphate adenylate kinase EC number 2.7.4.10 is an enzyme that catalysis catalyzes the chemical reaction nucleosidetriphosphate AMP math rightleftharpoons math nucleoside diphosphate ADP Thus, the two substrate biochemistry substrates of this enzyme are nucleosidetriphosphate and adenosine monophosphate AMP , whereas its two product chemistry products are nucleoside diphosphate and adenosine diphosphate ADP . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with a phosphate group as acceptor. The systematic name of this enzyme class is nucleosidetriphosphate AMP phosphotransferase . Other names in common use include guanosine triphosphate adenylate kinase , nucleosidetriphosphate adenosine monophosphate transphosphorylase , GTP AMP phosphotransferase , and isozyme 3 of adenylate kinase . This enzyme participates in pyrimidine metabolism . Structural studies As of late 2007, two tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1ZD8 and PDB link 2AK3 . References reflist 1 cite journal author Albrecht GJ date 1970 title Purification and properties of nucleosidetriphosphate adenosine monophosphate transphosphorylase from beef heart mitochondria journal Biochemistry. volume 9 pages 2462&ndash 70 pmid 5423264 doi 10.1021 bi00814a011 issue 12 cite journal author CHIGA M, ROGERS AE, PLAUT GW date 1961 title Nucleotide transphosphorylases from liver. II. Purification and properties of a 6 oxypurine nucleosidetriphosphate adenosine monophosphate transphosphorylase from swine liver journal J. Biol. Chem. volume 236 pages 1800&ndash 5 pmid 13693071 enzyme stub Category EC 2.7.4 Category Enzymes of known ... more details
enzyme Name nucleosidetriphosphate diphosphatase EC number 3.6.1.19 CAS number 9075 54 1 IUBMB EC number 3 6 1 19 GO code 0047429 image width caption In enzymology , a nucleosidetriphosphate diphosphatase EC number 3.6.1.19 is an enzyme that catalysis catalyzes the chemical reaction a nucleosidetriphosphate H sub 2 sub O math rightleftharpoons math a nucleotide diphosphate Thus, the two substrate biochemistry substrates of this enzyme are nucleosidetriphosphate and water H sub 2 sub O , whereas its two product chemistry products are nucleotide and diphosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on acid anhydrides in phosphorus containing anhydrides. The systematic name of this enzyme class is nucleosidetriphosphate diphosphohydrolase . This enzyme is also called nucleosidetriphosphate pyrophosphatase . This enzyme participates in purine metabolism and pyrimidine metabolism . Structural studies As of late 2007, 5 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1V7R , PDB link 2CAR , PDB link 2E5X , PDB link 2I5D , and PDB link 2J4E . References reflist 1 cite journal author Chern CJ, MacDonald AB, Morris AJ date 1969 title Purification and properties of a nucleosidetriphosphate pyrophosphohydrolase from red cells of the rabbit journal J. Biol. Chem. volume 244 pages 5489&ndash 95 pmid 4310599 issue 20 hydrolase stub Category EC 3.6.1 Category Enzymes of known structure ... more details
Multiple issues expert subject August 2008 cleanup August 2008 orphan February 2009 enzyme Name nucleosidetriphosphate hexose 1 phosphate nucleotidyltransferase EC number 2.7.7.28 CAS number 37278 26 5 IUBMB EC number 2 7 7 28 GO code 0047339 image width caption In enzymology , a nucleosidetriphosphate aldose 1 phosphate nucleotidyltransferase EC number 2.7.7.28 is an enzyme that catalysis catalyzes the chemical reaction nucleosidetriphosphate alpha D aldose 1 phosphate math rightleftharpoons math diphosphate NDP hexose Thus, the two substrate biochemistry substrates of this enzyme are nucleosidetriphosphate and alpha D aldose 1 phosphate , whereas its two product chemistry products are diphosphate and NDP hexose . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing nucleotide groups nucleotidyltransferase s . The systematic name of this enzyme class is NTP alpha D aldose 1 phosphate nucleotidyltransferase . Other names in common use include NDP hexose pyrophosphorylase , hexose 1 phosphate nucleotidyltransferase , hexose nucleotidylating enzyme , nucleoside diphosphohexose pyrophosphorylase , hexose 1 phosphate guanylyltransferase , GTP alpha D hexose 1 phosphate guanylyltransferase , GDP hexose pyrophosphorylase , guanosine diphosphohexose pyrophosphorylase , nucleosidetriphosphate hexose 1 phosphate nucleotidyltransferase , and NTP hexose 1 phosphate nucleotidyltransferase . References reflist 1 cite journal author Verachtert H, Rodriguez P, Bass ST, Hansen RG date 1966 title Purification and properties of guanosine diphosphate hexose pyrophosphorylase from mammalian tissues journal J. Biol. Chem. volume 241 pages 2007&ndash 13 pmid 5946626 issue 9 cite journal author Hansen RG, Verachtert H, Rodriguez P and Bass ST date 1966 title GDP hexose pyrophosphorylase from liver journal Methods Enzymol. volume 8 pages 269&ndash 271 doi 10.1016 0076 6879 66 08048 0 series Methods in Enzymology isbn 9780121818081 enzyme ... more details
. Use in medicine and technology In medicine several nucleoside analogues are used as antiviral or anticancer ... is prone to hydrolysis, several more stable alternative nucleoside nucleotide analogues that correctly ... nucleotides See also Adenosine triphosphate ATP Nucleotide Nucleobase Synthesis of nucleosides Nucleobases ... Nukleosido fr Nucl oside gl Nucle sido ko id Nukleosida it Nucleoside ka kk lt Nukleozidas hu Nukleozid nl Nucleoside ja oc Nucleosid pl Nukleozydy ru ... more details
enzyme Name nucleoside triphosphatase EC number 3.6.1.15 CAS number 9075 51 8 IUBMB EC number 3 6 1 15 GO code 0017111 image width caption In enzymology , a nucleoside triphosphatase EC number 3.6.1.15 is an enzyme that catalysis catalyzes the chemical reaction NTP H sub 2 sub O math rightleftharpoons math NDP phosphate Thus, the two substrate biochemistry substrates of this enzyme are nucleosidetriphosphate NTP and water H sub 2 sub O , whereas its two product chemistry products are nucleoside diphosphate NDP and phosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on acid anhydrides in phosphorus containing anhydrides. The systematic name of this enzyme class is unspecific diphosphate phosphohydrolase . Other names in common use include nucleosidetriphosphate phosphohydrolase , nucleoside 5 triphosphate phosphohydrolase , and nucleoside 5 triphosphatase . This enzyme participates in purine metabolism and thiamine metabolism . Structural studies As of late 2007, only one tertiary structure structure has been solved for this class of enzymes, with the Protein Data Bank PDB accession code PDB link 2I3B . References reflist 1 cite journal author Brightwell R, Tappel AL date 1968 title Lysosomal acid pyrophosphatase and acid phosphatase journal Arch. Biochem. Biophys. volume 124 pages 333&ndash 43 pmid 5661608 doi 10.1016 0003 9861 68 90335 4 issue 1 cite journal author LEWIS M, WEISSMAN S date 1965 title PROPERTIES OF A SOLUBLE NUCLEOSIDE TRIPHOSPHATASE ACTIVITY IN MAMMALIAN LIVER journal Arch. Biochem. Biophys. volume 109 pages 490&ndash 8 pmid 14320490 doi 10.1016 0003 9861 65 90393 0 issue 3 cite journal author Matsushita S, Raacke ID date 1968 title Purification of nucleoside triphosphatases from pea seedling ribosomes journal Biochim. Biophys. Acta. volume 166 pages 707&ndash 10 pmid 4301913 issue 3 hydrolase stub Category EC 3.6.1 Category Enzymes of known structure ... more details
triphosphate ATP , but its role in the organism is more specific than that of ATP. This statement ..., nucleosides, and nucleotides DEFAULTSORT Cytidine Triphosphate Category Nucleotides Category Pyrimidones ... de Cytidintriphosphat es Citidina trifosfato fr Cytidine triphosphate gl Citid n trifosfato ... more details
chembox Verifiedfields changed Watchedfields changed verifiedrevid ImageFile Desoxythymidintriphosphat protoniert.svg ImageSize IUPACName 2R,3S,5R 3 hydroxy 5 5 methyl 2,4 dioxopyrimidin 1 yl oxolan 2 yl methyl hydroxy phosphonooxyphosphoryl hydrogen phosphate OtherNames dTTP, 2 deoxythymidine triphosphate Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite changed chemspider ChemSpiderID 58493 ChEMBL Ref ebicite changed EBI ChEMBL 363559 InChI InChIKey StdInChI Ref stdinchicite correct chemspider StdInChI StdInChIKey Ref stdinchicite correct chemspider StdInChIKey CASNo Ref cascite changed ?? CASNo 365 08 2 PubChem 64968 IUPHAR ligand SMILES CC1 CN C O NC1 O C2CC C O2 COP O O OP O O OP O O O O MeSHName thymidine 5 triphosphate Section2 Chembox Properties Formula C sub 10 sub H sub 17 sub N sub 2 sub O sub 14 sub P sub 3 sub MolarMass 482.168 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Deoxythymidine triphosphate dTTP is one of the five nucleoside triphosphate s that are used in the in vivo synthesis of DNA . Unlike the other deoxyribonucleotide triphosphates, thymidine triphosphate does not contain the deoxy prefix in its name. ref cite book title The ACS style guide effective communication of scientific information year 2006 publisher American Chemical Society location Washington, D.C. isbn 9780841239999 edition 3rd editor Coghill, Anne M. Garson, Lorrin R. page 244 ref The corresponding ribonucleoside triphosphate is called 5 methyluridine triphosphate . It can be used by DNA ligase to create overlapping sticky ends so that protruding ends of opened microbial plasmid s may be closed up. Reflist reflist Nucleobases, nucleosides, and nucleotides Category Nucleotides genetics stub ca Trifosfat de timidina de Desoxythymidintriphosphat es Timidina trifosfato fa fr Thymidine triphosphate gl Desoxitimidina trifosfato nl Thymidinetrifosfaat ja sr Timidin trifosfat zh ... more details
Unreferenced date December 2009 Expert subject Chemistry date November 2008 Chembox verifiedrevid 417224336 ImageFile Desoxycytidintriphosphat protoniert.svg ImageSize IUPACName OtherNames Section1 Chembox Identifiers CASNo Ref cascite correct CAS CASNo 2056 98 6 PubChem 65091 SMILES C1C C OC1N2C CC NC2 O N COP O O OP O O OP O O O O Section2 Chembox Properties Formula C sub 9 sub H sub 16 sub N sub 3 sub O sub 13 sub P sub 3 sub MolarMass 467.156923 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Deoxycytidine triphosphate dCTP is a nucleoside triphosphate that is used whenever DNA is synthesized, such as in the polymerase chain reaction . e.g. A chemical equation can be written that represents the process DNA sub n sub dCTP DNA sub n sub C PP sub i sub That is, dCTP has the PP sub i sub pyrophosphate cleaved off and the Deoxycytidine monophosphate dCMP is incorporated into the DNA strand at the 3 end. Subsequent hydrolysis of the PP sub i sub drives the equilibrium of the reaction toward the right side, i.e. incorporation of the nucleotide in the growing DNA chain. It is stored at 20 degrees Celsius. See also DNA Replication Nucleobases, nucleosides, and nucleotides DEFAULTSORT Deoxycytidine Triphosphate Category Molecular biology Category Nucleotides Biochemistry stub ca Trifosfat de desoxicitidina de Desoxycytidintriphosphat fa gl Desoxicitidina trifosfato nl Deoxycytidinetrifosfaat sr Dezoksicitidin trifosfat zh ... more details
Refimprove date December 2009 Drugbox Verifiedfields changed verifiedrevid 457479092 IUPAC name 2R,3S,5R 3 hydroxy 5 5 methyl 2,4 dioxopyrimidin 1 yl oxolan 2 yl methyl hydroxy phosphonooxyphosphoryl hydrogen phosphate image 5 Methyluridintriphosphat protoniert.svg alt caption Clinical data tradename pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled legal CA OTC, Rx only, Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD Benz POM, CD Anab POM or CD Inv POM legal US OTC Rx only Schedule I, II, III, IV, V legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers CAS number Ref cascite changed ?? CAS number ? ATCvet ATC prefix none if uncategorised ATC suffix PubChem DrugBank Ref drugbankcite correct drugbank DrugBank ChEMBL Ref ebicite changed EBI ChEMBL 607677 Chemical data chemical formula C10 H17 N2 O15 P3 molecular weight 498.2 g mol smiles CC1 CN C2O C H COP O O OP O O OP O O O C H O C H 2O C O NC1 O 5 Methyluridine triphosphate or m sup 5 sup UTP is one of five nucleoside triphosphate s. It is the ribonucleoside triphosphate of thymidine , but the 5 methyluridine nomenclature is used because the term thymidine triphosphate is used for the deoxyribonucleoside by convention. ref cite book title The ACS style guide effective communication of scientific information year 2006 publisher American Chemical Society location Washington, D.C. isbn 9780841239999 edition 3rd editor Coghill, Anne M. Garson, Lorrin R. page 244 ref References reflist Nucleobases, nucleosides, and nucleotides DEFAULTSORT Thymidine Triphosphate Category Nucleotides Biochem stub ca Trifosfat de timidina de Desoxythymidintriphosphat fr Thymidine triphosphate nl Thymidinetrifosfaat ja sr Timidin trifosfat zh ... more details
Hazards Solubility MainHazards FlashPt Autoignition Guanosine 5 triphosphate GTP is a purine nucleosidetriphosphate . It can act as a substrate for the synthesis of RNA during the transcription genetics ... H 3 C H C H C H O3 CO P O O O P O O OP O O O O O nH c nc2 O N MeSHName Guanosine triphosphate Section2 ... attached to the 1 and the triphosphate moiety attached to the 5 carbons of the ribose. It also ... triphosphate ATP , but more specific. It is used as a source of energy for protein biosynthesis ... acid cycle . This is tantamount to the generation of one molecule of Adenosine triphosphate ... guanosine triphosphate redirects here Cyclic guanosine triphosphate cGTP helps cyclic adenosine monophosphate ... Triphosphate Category Nucleotides Category Purines bg ca Trifosfat de guanosina ... trifosfato fa fr Guanosine triphosphate gl Guanos n trifosfato it Guanosintrifosfato ... more details
Chembox Verifiedfields changed verifiedrevid 440114883 ImageFile Desoxyguanosintriphosphat protoniert.svg ImageSize IUPACName OtherNames Section1 Chembox Identifiers PubChem 65103 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 58613 ChEMBL Ref ebicite changed EBI ChEMBL 477486 ChEBI Ref ebicite changed EBI ChEBI 16497 SMILES O P O O OP O O OP O O OC C H 3O C H n1cnc2c1NC N C2 O N C C H 3O StdInChI Ref stdinchicite correct chemspider StdInChI 1S C10H16N5O13P3 c11 10 13 8 7 9 17 14 10 12 3 15 8 6 1 4 16 5 26 6 2 25 30 21,22 28 31 23,24 27 29 18,19 20 h3 6,16H,1 2H2, H,21,22 H,23,24 H2,18,19,20 H3,11,13,14,17 t4 ,5 ,6 m0 s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey HAAZLUGHYHWQIW KVQBGUIXSA N Section2 Chembox Properties Formula C sub 10 sub H sub 16 sub N sub 5 sub O sub 13 sub P sub 3 sub MolarMass 507.181023 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Deoxyguanosine triphosphate ref Lehninger4th ref dGTP is a nucleoside triphosphate , and a nucleotide precursor used in cells for DNA replication DNA synthesis . The substance is used in the polymerase chain reaction technique, in sequencing , and in cloning . It is also the competitor of inhibition onset by acyclovir in the treatment of Herpes simplex virus HSV virus . ref name pmid6285704 cite journal author Furman PA, Lambe CU, Nelson DJ title Effect of acyclovir on the deoxyribonucleoside triphosphate pool levels in Vero cells infected with herpes simplex virus type 1 journal Am. J. Med. volume 73 issue 1A pages 14 7 year 1982 month July pmid 6285704 doi 10.1016 0002 9343 82 90056 0 url issn ref References reflist 2 Nucleobases, nucleosides, and nucleotides DEFAULTSORT Deoxyguanosine Triphosphate Category Nucleotides Organic compound stub ca Trifosfat de desoxiguanosina de Desoxyguanosintriphosphat fa gl Desoxiguanosina trifosfato nl Deoxyguanosinetrifosfaat sr Dezoksiguanozin trifosfat zh ... more details
5 triphosphate ATP is a multifunctional nucleosidetriphosphate used in cell biology cells as a coenzyme ... hydrogen phosphate OtherNames adenosine 5 tetrahydrogen triphosphate Section1 ... sugar and three phosphate groups triphosphate . The phosphoryl groups, starting with the group ... title Thermodynamics of the hydrolysis of adenosine 5 triphosphate to adenosine 5 diphosphate url http ... and Company year 2002 isbn 0 7167 1843 X ref Ionization in biological systems ATP adenosine triphosphate ... molecule of the ATP equivalent guanosine triphosphate GTP through substrate level phosphorylation ... ATP replenishment by nucleoside diphosphate kinases ATP can also be synthesized through several so called replenishment reactions catalyzed by the enzyme families of nucleoside diphosphate kinase s NDKs , which use other nucleoside triphosphates as a high energy phosphate donor, and the ATP guanido ... agonists of P1 receptors, which are strongly activated by adenosine and other nucleoside s ADO AMP ...?cid 5957 PubChem entry for Adenosine Triphosphate http www.genome.jp dbget bin www bget?cpd C00002 KEGG entry for Adenosine Triphosphate Nucleobases, nucleosides, and nucleotides Enzyme cofactors Neurotransmitters good article DEFAULTSORT Adenosine Triphosphate Category Cellular respiration ... eo Adenozina trifosfato eu Adenosina trifosfato fa fr Ad nosine triphosphate gl Adenos n ... Adenosina trifosfat is Aden s n r fosfat it Adenosina trifosfato he ATP jv Adenosin Triphosphate ka ... Adenozintrifosfat simple Adenosine triphosphate sk Adenoz ntrifosf t sl Adenozin trifosfat sr ... more details
chembox verifiedrevid 384065455 ImageFile Ara CTP.svg ImageSize IUPACName OtherNames Ara CTP, Cytarabine triphosphate, br Cytosine arabinoside triphosphate Reference ref name pubchem http pubchem.ncbi.nlm.nih.gov summary summary.cgi?cid 25774 Ara CTP Compound Summary , PubChem . ref Section1 Chembox Identifiers CASNo 13191 15 6 PubChem 25774 SMILES C1 CN C O N C1N C2C C C O2 COP O O OP O O OP O O O O O MeSHName Arabinofuranosylcytosine triphosphate Section2 Chembox Properties Formula C sub 9 sub H sub 16 sub N sub 3 sub O sub 14 sub P sub 3 sub MolarMass 483.156323 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Arabinofuranosylcytosine triphosphate is a nucleotide that inhibits the protein biosynthesis synthesis of DNA . It is the biologically active form of cytarabine . ref name pubchem References reflist Nucleobases, nucleosides, and nucleotides Category Nucleotides Category Pyrimidones organic compound stub fa zh ... more details
triphosphate and thiamine triphosphatase activities from bacteria to mammals. Cell Mol Life Sci 60 ... Ref1 ref name Ref3 Lakaye B, Wirtzfeld B, Wins P, Grisar T & Bettendorff L. 2004 Thiamine triphosphate ... triphosphate deficiency in subacute necrotizing encephalomyelopathy. Science 164 74 75 pmid 5773712 ..., suppression of the carbon source leads to the accumulation, of adenosine thiamine triphosphate AThTP ... B. & Bettendorff L. 2010 Thiamine triphosphate synthesis in the rat brain is mitochondrial and coupled ... be converted into ThDP by thiamine diphosphate kinase . History Thiamine triphosphate ThTP was chemically synthesized in 1948 at a time when the only organic triphosphate known was ATP. ref Velluz L ... s yeast. ref Kiessling K. H. 1953 Thiamine triphosphate in baker s yeast Nature 172 1187 1188. ref ... unphosphorylated . ref Yusa T. 1962 Studies on thiamine triphosphate II. Thiamine triphosphate ... more details
. ref cite journal last1 Corbridge first1 D. E. C. title The crystal structure of sodium triphosphate ... structure of sodium triphosphate, Na5P3O10, phase II journal Acta Crystallographica volume ... are known including the cyclic triphosphate P sub 3 sub O sub 9 sub sup 3 sup . It binds strongly to metal cations as both a bidentate and tridentate chelating agent . Image Triphosphate chelation.svg thumb 180px left Chelation of a metal cation by triphosphate. Uses In detergents The majority of STPP ..., Adenosine triphosphate ATP , a related derivative of triphosphate, is essential for life ... more details
enzyme Name nucleoside diphosphatase EC number 3.6.1.6 CAS number 9027 69 4 IUBMB EC number 3 6 1 6 GO code 0017110 image width caption In enzymology , a nucleoside diphosphatase EC number 3.6.1.6 is an enzyme that catalysis catalyzes the chemical reaction a nucleoside diphosphate H sub 2 sub O math rightleftharpoons math a nucleotide phosphate Thus, the two substrate biochemistry substrates of this enzyme are nucleoside diphosphate and water H sub 2 sub O , whereas its two product chemistry products are nucleotide and phosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on acid anhydrides in phosphorus containing anhydrides. The systematic name of this enzyme class is nucleoside diphosphate phosphohydrolase . Other names in common use include thiaminpyrophosphatase , UDPase , inosine diphosphatase , adenosine diphosphatase , IDPase , ADPase , adenosinepyrophosphatase , guanosine diphosphatase , guanosine 5 diphosphatase , inosine 5 diphosphatase , uridine diphosphatase , uridine 5 diphosphatase , nucleoside diphosphate phosphatase , type B nucleoside diphosphatase , GDPase , CDPase , nucleoside 5 diphosphatase , type L nucleoside diphosphatase , NDPase , and nucleoside diphosphate phosphohydrolase . This enzyme participates in purine metabolism and pyrimidine metabolism . Structural studies As of late 2007, two tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 2H2N and PDB link 2H2U . References reflist 1 cite journal author GIBSON DM, AYENGAR P, SANADI DR date 1955 title A phosphatase specific for nucleoside diphosphates journal Biochim. Biophys. Acta. volume 16 pages 536&ndash 8 pmid 14389272 doi 10.1016 0006 3002 55 90275 4 issue 4 cite journal author Horecker BL, Hurwitz J and Heppel LA date 1957 title The synthesis of ribose 5 pyrophosphate and ribose 5 triphosphate journal J. Am. Chem. Soc. volume 79 pages 701&ndash 702 doi 10.1021 ja01560a054 issue 3 ... more details
Orphan date February 2009 chembox verifiedrevid 402880365 ImageFile xanthosine triphosphate.png ImageSize 200px IUPACName 2 R ,3 S ,4 R 5 2,6 dioxo 3 H purin 9 yl 3,4 dihydroxy 2 tetrahydrofuranyl methyl hydroxy phosphonooxyphosphoryl hydrogen phosphate OtherNames Section1 Chembox Identifiers InChI 1 C10H12N4O6.3H3O4P c15 1 3 5 16 6 17 9 20 3 14 2 11 4 7 14 12 10 19 13 8 4 18 3 1 5 2,3 4 h2 3,5 6,9,15 17H,1H2, H2,12,13,18,19 3 H3,1,2,3,4 t3 ,5 ,6 ,9 m1... s1 InChIKey BKBQKVXTMZOVRH CYCLDIHTBT StdInChI Ref stdinchicite correct chemspider StdInChI 1S C10H12N4O6.3H3O4P c15 1 3 5 16 6 17 9 20 3 14 2 11 4 7 14 12 10 19 13 8 4 18 3 1 5 2,3 4 h2 3,5 6,9,15 17H,1H2, H2,12,13,18,19 3 H3,1,2,3,4 t3 ,5 ,6 ,9 m1... s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey BKBQKVXTMZOVRH CYCLDIHTSA N CASNo 6253 56 1 PubChem 121887 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 19980202 SMILES OP O O O.OP O O O.OP O O O.O C3Nc2c ncn2 C H 1O C H CO C H O C H 1O C O N3 Section2 Chembox Properties Formula C sub 10 sub H sub 15 sub N sub 4 sub O sub 15 sub P sub 3 sub MolarMass 524.17 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Xanthosine 5 triphosphate XTP is a nucleotide that is not produced by and has no known function in living cells. Uses of XTP are, in general, limited to experimental procedures on enzymes that bind other nucleotides. See also Xanthosine Xanthosine monophosphate Nucleobases, nucleosides, and nucleotides Category Nucleotides Category Purines organic compound stub biochemistry stub fa fr Xanthosine triphosphate ... more details
Orphan date January 2010 Chembox verifiedrevid 443356640 ImageFile 7,8 Dihydroneopterin triphosphate.png ImageSize 200px IUPACName OtherNames DHNTP Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 108735 InChI 1 C9H16N5O13P3 c10 9 13 7 5 8 17 14 9 12 3 1 11 7 6 16 4 15 2 25 29 21,22 27 30 23,24 26 28 18,19 20 h4,6,15 16H,1 2H2, H,21,22 H,23,24 H2,18,19,20 H4,10,11,13,14,17 t4 ,6 m1 s1 InChIKey DGGUVLXVLHAAGT XINAWCOVBB SMILES1 O P O O OP O O OP O O OC C H O C H O C 1 N C 2C O N C NC 2NC 1 N StdInChI Ref stdinchicite correct chemspider StdInChI 1S C9H16N5O13P3 c10 9 13 7 5 8 17 14 9 12 3 1 11 7 6 16 4 15 2 25 29 21,22 27 30 23,24 26 28 18,19 20 h4,6,15 16H,1 2H2, H,21,22 H,23,24 H2,18,19,20 H4,10,11,13,14,17 t4 ,6 m1 s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey DGGUVLXVLHAAGT XINAWCOVSA N CASNo 17088 65 2 PubChem ChEBI Ref ebicite correct EBI ChEBI 18372 SMILES O C1C2 C NCC C H C H COP OP OP O O O O O O O O O N2 NC N N1 Section2 Chembox Properties C 9 H 16 N 5 O 13 P 3 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition 7,8 Dihydroneopterin triphosphate DHNTP is an intermediate in tetrahydrobiopterin biosynthesis . References Unreferenced date September 2009 Reflist DEFAULTSORT Dihydroneopterin triphosphate, 7,8 Category Organophosphates Category Pteridines organic compound stub ja 7,8 ... more details
enzyme Name nucleoside phosphotransferase EC number 2.7.1.77 CAS number 9055 37 2 IUBMB EC number 2 7 1 77 GO code 0050146 image width caption In enzymology , a nucleoside phosphotransferase EC number 2.7.1.77 is an enzyme that catalysis catalyzes the chemical reaction a nucleotide a 2 deoxynucleoside math rightleftharpoons math a nucleoside a 2 deoxynucleoside 5 phosphate Thus, the two substrate biochemistry substrates of this enzyme are nucleotide and 2 deoxynucleoside , whereas its two product chemistry products are nucleoside and 2 deoxynucleoside 5 phosphate . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with an alcohol group as acceptor. The systematic name of this enzyme class is nucleotide nucleoside 5 phosphotransferase . Other names in common use include nonspecific nucleoside phosphotransferase , and nucleotide 3 deoxynucleoside 5 phosphotransferase . References reflist 1 cite journal author Brunngraber EF, Chargaff E date 1967 title Purification and properties of a nucleoside phosphotransferase from carrot journal J. Biol. Chem. volume 242 pages 4834&ndash 40 pmid 6061424 issue 20 cite journal author Prasher DC, Carr MC, Ives DH, Tsai TC, Frey PA date 1982 title Nucleoside phosphotransferase from barley. Characterization and evidence for ping pong kinetics involving phosphoryl enzyme journal J. Biol. Chem. volume 257 pages 4931&ndash 9 pmid 6279651 issue 9 kinases enzyme stub Category EC 2.7.1 Category Enzymes of unknown structure ... more details
enzyme Name nucleoside ribosyltransferase EC number 2.4.2.5 CAS number 9030 31 3 IUBMB EC number 2 4 2 5 GO code 0050147 image width caption In enzymology , a nucleoside ribosyltransferase EC number 2.4.2.5 is an enzyme that catalysis catalyzes the chemical reaction D ribosyl base sub 1 sub base sub 2 sub math rightleftharpoons math D ribosyl base sub 2 sub base sub 1 sub Thus, the two substrate biochemistry substrates of this enzyme are D ribosyl base sub 1 sub and base sub 2 sub , whereas its two product chemistry products are D ribosyl base sub 2 sub and base sub 1 sub . This enzyme belongs to the family of glycosyltransferase s, specifically the pentosyltransferases. The systematic name of this enzyme class is nucleoside purine pyrimidine D ribosyltransferase . This enzyme is also called nucleoside N ribosyltransferase . References reflist 1 cite journal author KOCH AL date 1956 title Some enzymes of nucleoside metabolism of Escherichia coli journal J. Biol. Chem. volume 223 pages 535&ndash 49 pmid 13376622 issue 1 enzyme stub Category EC 2.4.2 Category Enzymes of unknown structure ... more details
Unreferenced stub auto yes date December 2009 Nucleoside analogues are a range of antiviral products used to prevent virus viral replication in infected cells. The most commonly used is Acyclovir , although its inclusion in this category is uncertain, as it contains only a partial nucleoside structure, as the pentose sugar ring is replaced by an open chain structure. Function These agents can be used against hepatitis B virus , hepatitis C virus , herpes simplex , and HIV . Once they are Phosphorylation phosphorylated , they work as antimetabolite s by being similar enough to nucleotide s to be incorporated into growing DNA strands but they act as chain terminators and stop viral DNA Polymerase. They are not specific to viral DNA and also affect mitochondrial DNA. Because of this they have side effects such as bone marrow suppression. There is a large family of reverse transcriptase inhibitor Nucleoside analog reverse transcriptase inhibitors NARTIs or NRTIs nucleoside analogue reverse transcriptase inhibitor s, because DNA production by reverse transcriptase is very different from normal human DNA replication , so it is possible to design nucleoside analogues that are preferentially incorporated by the former. Some nucleoside analogues, however, can function both as NRTIs and polymerase inhibitors for other viruses e.g., hepatitis B . Less selective nucleoside analogues are used as chemotherapy agents to treat cancer . Resistance Resistance can develop quickly with as little as one mutation. Citation needed reason an example from the literature would be nice date March 2009 Mutations occur in the enzymes that phosphorylate the drug to activate it. Examples Nucleoside analogue .... See also For nucleoside analogues in biology, see Nucleic acid analogues Antivirals HIVpharm DEFAULTSORT Nucleoside Analogue Category Antivirals Category Nucleosides Antimicrobial stub fr Analogue de nucl osides nl Nucleoside analoog ... more details
Nucleoside transporters NTs are a group of membrane transport protein s which transport nucleoside Substrate biochemistry substrates like adenosine across the biological membrane membrane s of Cell biology cell s and or vesicle biology vesicles . ref name pmid19485885 cite journal author Molina Arcas M, Casado FJ, Pastor Anglada M title Nucleoside transporter proteins journal Current Vascular Pharmacology volume 7 issue 4 pages 426 34 year 2009 month October pmid 19485885 doi url http www.bentham direct.org pages content.php?CVP 2009 00000007 00000004 002AD.SGM ref There are two known types of nucleoside transporters, concentrative nucleoside transporter s CNTs SLC28 and equilibrative nucleoside transporter s ENTs SLC29 , as well as possibly a yet unidentified vesicular transporter. ref name pmid19485885 References Reflist 2 Further reading cite journal author Molina Arcas M, Casado FJ, Pastor Anglada M title Nucleoside Transporter Proteins journal Current Vascular Pharmacology volume 7 issue 4 pages 426 34 year 2009 month October pmid 19485885 doi url http www.bentham direct.org pages content.php?CVP 2009 00000007 00000004 002AD.SGM cite journal author Molina Arcas M, Trigueros Motos L, Casado FJ, Pastor Anglada M title Physiological and pharmacological roles of nucleoside transporter proteins journal Nucleosides, Nucleotides & Nucleic Acids volume 27 issue 6 pages 769 78 year 2008 month June pmid 18600539 doi 10.1080 15257770802145819 url cite journal author Gray JH, Owen RP, Giacomini KM title The concentrative nucleoside transporter family, SLC28 journal Pfl gers Archiv European Journal of Physiology volume 447 issue 5 pages 728 34 year 2004 month February pmid 12856181 doi 10.1007 s00424 003 1107 y cite journal author Baldwin SA, Beal PR, Yao SY, King AE, Cass CE, Young JD title The equilibrative nucleoside transporter family, SLC29 journal Pfl gers Archiv European Journal of Physiology volume 447 issue 5 pages 735 43 year 2004 month February pmid 12838422 doi 10.1007 ... more details
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