- Ofatumumab
NA Chemical data C 6480 H 10022 N 1742 O 2020 S 44 molecular weight 146.1 kDa Ofatumumab ref cite journal last Zhang first Bodi title Ofatumumab journal MAbs year 2009 volume 1 issue 4 pages 326 331 ... arthritis and relapsing remitting multiple sclerosis . Ofatumumab has also received conditional approval in Europe for the treatment of refractory chronic lymphocytic leukemia. This makes ofatumumab ... CLL. Mechanism Ofatumumab targets an epitope different from rituximab and most other CD20 directed antibodies. Ofatumumab binds to both the small and large loops of the CD20 molecule on B cells ... 2009 4384.aspx FDA Approves Ofatumumab Arzerra for Patients With CLL Refractory to Fludarabine and Alemtuzumab ... leukemia in 2010. Clinical trials Status of clinical trials of ofatumumab conducted by Genmab ... RA Phase III &ndash OFA110635 GEN410 &ndash Ofatumumab in adult RA patients who have had an inadequate response to methotrexate ref ClinicalTrialsGov NCT00611455 Investigating Clinical Efficacy of Ofatumumab ... GEN411 &ndash Ofatumumab in adult RA patients who have had an inadequate response to TNF alpha antagonist therapy ref ClinicalTrialsGov NCT00603525 Investigating Clinical Efficacy of Ofatumumab ... B cell lymphoma DLBCL &ndash Phase III ref ClinicalTrialsGov NCTNCT01014208 Ofatumumab Versus Rituximab ... Safety and efficacy of ofatumumab, a fully human monoclonal anti CD20 antibody, in patients with relapsed ... Ofatumumab journal MAbs volume 1 issue 4 pages 326 31 year 2009 month July pmid 20068404 pmc 2726602 ... antibody stub antineoplastic drug stub de Ofatumumab es Ofatumumab it Ofatumumab ... more details
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- HuMax
HuMax is an abbreviation for human monoclonal antibody targeting... , used by the pharmaceutical company Genmab in trade names. Examples include HuMax CD4 zanolimumab HuMax CD20 ofatumumab HuMax Epidermal growth factor receptor EGFr zalutumumab Category Monoclonal antibodies ... more details
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- Genmab
worth 1.6 billion for the antibody ofatumumab. Besides GSK, Genmab also has licensing ... news pressreleases newsitem.asp?id 2005 0224 01 ref The Company s first product, Arzerra ofatumumab ... entered a deal with GlaxoSmithKline to co develop and commercialize ofatumumab, which is a drug ... and GSK amended the agreement in July 2010. GSK has taken responsibility for developing ofatumumab in autoimmune indications while continuing to jointly develop ofatumumab with Genmab in oncology ... Ofatumumab 20 Studies Chronic lymphocytic leukemia CLL III GSK Ofatumumab Non Hodgkin s Lymphoma NHL III GSK Ofatumumab Rheumatoid arthritis RA III GSK Ofatumumab Diffuse Large B cell Lymphoma DLBCL III GSK Ofatumumab Relapsing Remitting Multiple Sclerosis RRMS II GSK Ofatumumab Waldenstrom s Macroglobulinemia ... more details
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- List of chemotherapeutic agents
This is a list of specific Wiktionary pharmacological agent pharmacologic agents that are known to be of use in the treatment of cancer , otherwise known as Wiktionary chemotherapeutic agent chemotherapeutic agents . This list is organized by type of agent, though the subsections are not necessarily definitive and are subject to revision. Each drug is listed once at present , though it might fall in more than one subsection. A full alphabetical listing is included after the categorical listing. Expand list date August 2008 Alkylating agents Cyclophosphamide Mechlorethamine Chlorambucil Melphalan Anthracyclines article on anthracycline s Daunorubicin Doxorubicin Epirubicin Idarubicin Mitoxantrone Valrubicin Cytoskeletal disruptors Taxanes Paclitaxel Docetaxel Epothilones article on epothilone s Histone Deacetylase Inhibitors Vorinostat Romidepsin Inhibitors of Topoisomerase II Etoposide Teniposide Tafluposide Kinase Inhibitors Bortezomib Erlotinib Gefitinib Imatinib Vismodegib Monoclonal Antibodies Bevacizumab Cetuximab Ipilimumab Ofatumumab Ocrelizumab Panitumab Rituximab Vemurafenib Nucleotide analogs and precursor analogs Azacitidine Azathioprine Capecitabine Cytarabine Doxifluridine Fluorouracil Gemcitabine Hydroxyurea Mercaptopurine Methotrexate Tioguanine formerly Thioguanine Peptide antibiotics Bleomycin Actinomycin Platinum based agents Carboplatin Cisplatin Oxaliplatin Retinoids Tretinoin Alitretinoin Bexarotene Vinca alkaloids and derivatives Vinblastine Vincristine Vindesine Vinorelbine Full alphabetical listing Actinomycin All trans retinoic acid Azacitidine Azathioprine Bleomycin Bortezomib Carboplatin Capecitabine Cisplatin Chlorambucil Cyclophosphamide Cytarabine Daunorubicin Docetaxel Doxifluridine Doxorubicin Epirubicin Epothilone Etoposide Fluorouracil Gemcitabine Hydroxyurea Idarubicin Imatinib Mechlorethamine Mercaptopurine Methotrexate Mitoxantrone Oxaliplatin Paclitaxel Pemetrexed Teniposide Tioguanine Valrubicin Vinblastine Vincristine Vindesin ... more details
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- List of drugs: Aq-Ar
Nonproprietary Name INN arz Ofatumumab Arzerra ... more details
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- Ocrelizumab
s Rituximab , a chimeric CD20 antagonist. Ofatumumab HuMax CD20 a fully human CD20 antagonist References ... more details
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- ATC code L01
L01XC10 Ofatumumab L01XC11 Ipilimumab L01XC12 Brentuximab vedotin anchor L01XD L01XD Sensitizers ... more details
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- List of drugs: O-Op
Name INN ofatumumab International Nonproprietary Name INN oglufanide disodium United States ... more details
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- Rituximab
agent. ofatumumab HuMax CD20 a fully human B cell depleting agent. ref name titleGenmab.com HuMax CD20 ofatumumab cite web url http www.genmab.com ScienceAndResearch ProductsinDevelopment HuMax CD20.aspx title Genmab.com HuMax CD20 ofatumumab accessdate 2007 12 03 format work archiveurl http web.archive.org ... more details
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- Belimumab
been approved for some indications. Ocrelizumab , ofatumumab and third generation anti CD20 monoclonals ... more details
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- CD20
s and leukemias . The anti CD20 mAB Ofatumumab Genmab was approved by FDA in Oct 2009 for Chronic ... more details
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- Monoclonal antibody therapy
4 integrin , Multiple sclerosis and Crohn s disease Ofatumumab Arzerra 2009 Human CD20 Chronic lymphocytic ... more details
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- List of monoclonal antibodies
rejections, immunological diseases Ofatumumab ref name WHOList93 Arzerra mab human CD20 chronic ... more details
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- Therapies under investigation for multiple sclerosis
pmid 18951300 ref Ofatumumab , other anti CD20 monoclonal antibody, also in phase II for MS, and phase ... more details
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