Multiple issues orphan August 2010 context July 2010 context August 2010 confusing November 2010 Olfactory ensheathing glia OG is a type of radial glia found in the olfactory mucosa and olfactory bulb . They are also known as olfactory Schwann cell s because of their properties in assisting axonal regeneration . Olfactory glia are capable of Phagocytosis phagocytosing axonal debris in vivo wewetzer et al., 2005 . In vitro, they phagocytose bacteria olfactory glia express Lyz protein s are thought to play an important role in immunoprotection in the mucosa Vincent et al., 2005 , where neuron s are directly exposed to external environment. These glia express Glial marker s such as glial fibrillary acidic protein , s100, and p75, and radial glial markers such as nestin and vimentin . OG have been tested successfully in experimental axon regeneration in rat spinal cord injury models li et al., 2003 and are currently in the clinical trial phase. neuroscience stub Category Nervous system ... more details
one source date September 2011 orphan date September 2011 Accessory olfactory cortical areas are portions of the human amygdala that are homologous to those areas in other species that receive afferents from the accessory olfactory bulb . They include the caudal part of the medial amygdalar nucleus, and the cortical amygdalar nucleus. ref citebook author Price JL year 1990 chapter Olfactory System title The Human Nervous System editor G. Paxinos publisher Academic Press location San Diego oclc 2830021034614 ref References Reflist External links More information at http braininfo.rprc.washington.edu centraldirectory.aspx?ID 2277 BrainInfo Categories Category Neuroanatomy neuroanatomy stub ... more details
The Primary olfactory cortex is a portion of the Cerebral cortex cortex involved in olfaction . ref name urlSylvius Neuroanatomical Reference Cite web url http www.sylvius.com ?s 234&i 3e 1401D&l 0 title Sylvius Neuroanatomical Reference format work accessdate 2009 11 20 ref ref name pmid19305509 Cite journal author Zelano C, Montag J, Khan R, Sobel N title A specialized odor memory buffer in primary olfactory cortex journal PLoS ONE volume 4 issue 3 pages e4965 year 2009 pmid 19305509 pmc 2654926 doi 10.1371 journal.pone.0004965 url ref ref name pmid10995842 Cite journal author Johnson DM, Illig KR, Behan M, Haberly LB title New features of connectivity in piriform cortex visualized by intracellular injection of pyramidal cells suggest that primary olfactory cortex functions like association cortex in other sensory systems journal J. Neurosci. volume 20 issue 18 pages 6974 82 year 2000 month September pmid 10995842 doi url ref Some sources state that it includes the prepyriform area and entorhinal area . ref name urlAnatomy of Olfactory System eMedicine Clinical Procedures Cite web url http emedicine.medscape.com article 835585 overview title Anatomy of Olfactory System eMedicine Clinical Procedures format work accessdate 2009 11 20 ref Other sources state that it consists of the prepiriform cortex and periamygdaloid cortex . ref name isbn0 7817 2829 0 Cite book author Fix, James D. title Neuroanatomy publisher Lippincott Williams & Wilkins location Hagerstwon, MD year 2002 pages 326 isbn 0 7817 2829 0 oclc doi accessdate ref References Reflist External links http isc.temple.edu neuroanatomy lab atlas bgalic Olfactory system Category Neuroanatomy Category Olfactory system Anatomy stub ... more details
Olfactory Reference Syndrome ORS also referred to as Autodysomophobia ref name ocdla http www.ocdla.com olfactoryreferencesyndrome.html Olfactory Reference Syndrome OCD Center of Los Angeles ref is a mental disorder psychiatric condition in which the affected person is excessively preoccupied by the concern that one s body odor is foul or unpleasant. This disorder is often accompanied by shame , embarrassment , significant Distress medicine distress , Avoidant personality disorder avoidance behavior , social anxiety disorder social phobia and social isolation . ref name ocdla ref name Lochner cite journal author Lochner C, Stein DJ date October 1, 2003 title Olfactory Reference Syndrome Diagnostic Criteria and Differential Diagnosis journal J Postgrad Med volume 49 issue 4 pages 328 331 url http www.jpgmonline.com text.asp?2003 49 4 328 4976 pmid 14699232 format dead link date March 2010 ref ORS is not recognised by the Diagnostic and Statistical Manual of Mental Disorders , however it is considered by many to be a sub type of Body dysmorphic disorder . ORS links obsessive and compulsive aspects. Sufferers may have trouble concentrating at a given task or in particular situations due to obsessive thoughts concerning body odor. Symptoms Common symptoms of ORS include excessive thoughts of having ref name ocdla halitosis bad breath anal odor vaginal odor overall body odor an unnatural, non human or chemical odor People with ORS believe others behaviors or comments are related to the imagined ... use of scented candles. Over consumption of mint and or gum. Treatment Olfactory reference syndrome ... Documents Feusner ORS.pdf OLFACTORY REFERENCE SYNDROME ISSUES FOR DSM V http www.mghocd.org ors Olfactory Reference Syndrome OCD and Related Disorders Clinic and Research Unit at Massachusetts General Hospital http bddclinic.info joomla index.php?option com content&task view&id 29&Itemid 53 Olfactory ... olfactoryreferencesyndrome.html Olfactory Reference Syndrome OCD Center of Los Angeles References ... more details
just given birth imprint onto their lambs on the basis of olfaction olfactory cues, allowing mothers to distinguish their own offspring from other lambs in the herd flock . This olfactory based imprinting .... Olfactory regulation of maternal behavior in mammals. Hormones and behavior, 46 3 , p.284 302. ref ... Important for Olfactory Imprinting The expression of maternal behavior in sheep follows a fairly ... s own fluid. It has been speculated that this is due to some olfactory signature of the ewe s amniotic ... attention paid to an unwashed lamb and the lessened olfactory cues to which the mother can have access through licking. ref name Poin10 Involvement of the Primary and or Secondary Olfactory Systems When ... olfactory system , the accessory olfactory system or both are responsible for the establishment ..., ewes whose primary olfactory systems were incapacitated by nasal irrigation with zinc sulfate procaine ... L vy, F. et al., 1995. Involvement of the main but not the accessory olfactory system in maternal behavior ... of both an anterograde tracer and postmortem examination of the accessory olfactory bulb. This experiment ... and selectivity. The ewes whose primary olfactory system was disabled were impaired in responsiveness ... olfactory signature. While a number of compounds were isolated, a synthetic reproduction of these substances ..., B.V. et al., 2011. Olfactory Cue Mediated Neonatal Recognition in Sheep, Ovis aries. Journal of chemical ... nucleus of the stria terminalis , medial preoptic area and the olfactory bulb . It appears that this oxytocin release indirectly primes the main olfactory bulb such that this region may optimally ... synapse synaptic changes within the olfactory bulb. Electrophysiological recordings from olfactory ... cells. ref name Kendrick97 Kendrick, K.M. et al., 1997. Formation of olfactory memories mediated ... that olfactory recognition of the lamb could be dependent on cholinergic neurons of the horizontal limb of the diagonal band of Broca projecting to olfactory targets. This does appear to be the case ... more details
Functions The sensory receptors involved in taste and smell contain receptor biochemistry receptor molecules that bind to specific chemicals. Odor receptor s in olfactoryreceptor neuron s, for example ...In a sensory system , a sensory receptor is a sensory nerve ending ref http www.encyclopedia.com doc ... environment of an organism . In response to stimuli the sensory receptor initiates sensory transduction ... fire action potentials when their membranes are physically stretched. The sensory receptor functions .... The stimulus modality to which a sensory receptor responds is determined by the sensory receptor s adequate stimulus . The sensory receptor responds to its stimulus modality by initiating sensory transduction. This may be accomplished by a net shift in the initial states of a receptor see a picture ... http www.bio balance.com Graphics.htm . Classification by adequate stimulus A sensory receptor ... receptors can be classified by location Cutaneous receptor s are sensory receptors found in the dermis or Epidermis skin epidermis . ref http medical dictionary.thefreedictionary.com Cutaneous receptor ... skin epidermis . Encapsulated receptor s consist of the remaining types of cutaneous receptors. Encapsulation exists for specialized functioning. by rate of adaptation A tonic receptor is a sensory receptor that adapts slowly to a stimulus ref name caspar http caspar.bgsu.edu courses Glossary.htm ... ref A phasic receptor is a sensory receptor that adapts rapidly to a stimulus. The response of the cell ... intensity and rate. ref name frank An example of a phasic receptor is the Pacinian corpuscle ... also Portal Neuroscience Sense Sensory neuron Proprioception Receptor theory References Reflist External ... DEFAULTSORT Sensory Receptor Category Sensory receptors bg cs Smyslov org n et Retseptor es Receptor sensorial fr R cepteur sensoriel id Reseptor indra it Recettore sensoriale he kk hu Receptor mk nl Zenuwreceptor pl Receptor pt Receptor sensorial ... more details
functional receptor has been identified that is expressed in the human olfactory system ... pheromone receptor gene expressed in human olfactory mucosa journal Nat. Genet. volume 26 issue ...Pfam box Symbol Vmron rcpt 1 Name Vomeronasal receptor, type 1 Pfam PF03402 InterPro IPR004072 PROSITE image PDB Pheromones have evolved in all animal phyla, to signal sex and dominance status, and are responsible for stereotypical social and sexual behaviour among members of the same species. In mammals, these chemical signals are believed to be detected primarily by the vomeronasal organ VNO , a chemosensory organ located at the base of the nasal septum ref name PUB00007338 Cite journal author Pantages E, Dulac C title A novel family of candidate pheromone receptors in mammals journal Neuron volume 28 issue 3 pages 835 845 year 2000 pmid 11163270 doi 10.1016 S0896 6273 00 00157 4 ref . The VNO is present in most amphibia, reptiles and non primate mammals but is absent in birds, adult catarrhine monkeys and apes ref name PUB00007339 Cite journal author Keverne EB title The vomeronasal organ journal Science volume 286 issue 5440 pages 716 720 year 1999 pmid 10531049 doi 10.1126 science.286.5440.716 ref . An active role for the human VNO in the detection of pheromones is disputed the VNO is clearly present in the fetus but appears to be atrophied or absent in adults. Three distinct families of putative pheromone receptors have been identified in the vomeronasal organ V1Rs, V2Rs and V3Rs . All are G protein coupled receptors but are only distantly related to the receptors of the main olfactory system, highlighting their different role ref name PUB00007338 . The V1 receptors share between 50 and 90 sequence identity but have little similarity to other families of G protein coupled ... V1 receptor homologues have also been found. The majority of these human sequences are pseudogenes ... of nonfunctional V1R like pheromone receptor sequences in human journal Genome Res. volume ... more details
Other uses Receptor disambiguation Technical date May 2008 In the field of biochemistry , a receptor ... originating externally from the cell. Through binding to a receptor, these signals direct a cell ... are protein molecules, embedded in either the plasma membrane cell surface receptor s or the cytoplasm or cell nucleus nucleus nuclear receptor s of a cell, to which one or more specific kinds of signal transduction signaling molecules may attach. A molecule which binds attaches to a receptor is called ... , a hormone , a pharmaceutical drug, or a toxin. Numerous receptor types ... each type of receptor recognizes and binds only certain ligand shapes in analogy to a lock and key where the lock represents the receptor and the key, its ligand . Hence the selective binding of specific a ligand to its receptor activates or inhibits a specific biochemical pathway. Ligand binding stabilizes a certain receptor conformational change conformation the three dimensional shape of the receptor ... to some sort of cellular response. However, some ligands e.g. Receptor antagonist antagonists ... receptor.svg thumb right Transmembrane receptor E extracellular space I intracellular space P plasma ... categories peripheral membrane protein s transmembrane protein s G protein coupled receptor s Composed ... receptor and related nicotinicoid receptors journal J. Biol. Chem. volume 279 issue 19 pages ... at the interface between the subunits. receptor tyrosine kinase Functional receptors are homodimers ... s nuclear receptor s Composed of a C terminus C terminal DNA binding domain DBD and a N terminus ... left mathrm Ligand right cdot left mathrm Receptor right overset K d rightleftharpoons left text Ligand receptor complex right math the brackets stand for concentrations center One measure of how well a molecule fits a receptor is the binding affinity, which is inversely related to the dissociation ... achieved after a significant number of receptors are activated. The receptor ligand affinity is greater ... more details
DISPLAYTITLE 5 HT sub 1E sub receptor PBB geneid 3354 5 hydroxytryptamine serotonin 1E receptor 5 HT sub 1E sub is a highly expressed human G protein coupled receptor ref name pmid2664084 cite journal ... of a novel serotonin receptor subtype 5 HT1E in human brain interaction with a GTP binding protein ... receptor subtype 5 HT1E in human brain interaction with a GTP binding protein. volume 53 issue 2 pages 465 71 journal Journal of neurochemistry ref that belongs to the 5 HT1 receptor family G sub i sub coupled serotonin receptor . ref name pmid1608964 cite journal doi 10.1073 pnas.89.12.5517 author ... L. L. and Whiting P. 1992 Molecular cloning of a serotonin receptor from human brain 5HT1E a fifth 5HT1 ..., 5517 5521. pmid 1608964 year 1992 title Molecular cloning of a serotonin receptor from human brain ... of a human gene S31 encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase ... receptor S31 locus HTR1E to human chromosome 6q14 q15 volume 22 issue 3 pages 637 40 doi 10.1006 ... web title Entrez Gene HTR1E 5 hydroxytryptamine serotonin receptor 1E url http www.ncbi.nlm.nih.gov ... HT sub 1E sub receptor is unknown due to the lack of selective pharmacological tools, specific antibodies ... pmc 2827198 journal Journal of neurochemistry ref The 5 HT sub 1E sub receptor gene lacks polymorphisms ... sequence, which suggests that the 5 HT sub 1E sub receptor has an important physiological role ... of the human serotonin 1E 5 HT1E receptor protein points to its evolutionary conservation. Brain ... variants of the human serotonin 1E 5 HT1E receptor protein points to its evolutionary conservation ... that the 5 HT sub 1E sub receptor is involved in the regulation of memory in humans due to the high abundance of receptors in the frontal cortex, hippocampus, and olfactory bulb, all of which are regions ... D. L. 2004 Molecular cloning and pharmacological characterization of the guinea pig 5 HT1E receptor ... characterization of the guinea pig 5 HT1E receptor volume 484 issue 2 3 pages 127 ... more details
A somatomedin receptor is a receptor which binds somatomedin . There are two types Insulin like growth factor 1 receptor Insulin like growth factor 2 receptor External links MeshName Somatomedin Receptor Growth factor receptors Category Receptors biochem stub ... more details
Opioid receptors are a group of G protein coupled receptor s with opioid s as Ligand biochemistry ligands ... to somatostatin receptor biochemistry receptor s SSTRs . Opiate receptors are distributed widely ... their actions at specific receptor sites, and that there were likely to be multiple such sites. ref ... detailed binding study of what would turn out to be the opioid receptor, using tritium sup 3 sup H naloxone . ref name pmid4687585 cite journal author Pert CB, Snyder SH title Opiate receptor demonstration ... definitive finding of an opioid receptor, although two other studies followed shortly after ... url ref Purification Purification of the receptor further verified its existence. The first attempt to purify the receptor involved the use of a novel opioid receptor antagonist called chlornaltrexamine that was demonstrated to bind to the opioid receptor ref name pmid86208 cite journal author Caruso TP, AE Takemori, DL Larson, PS Portoghese title Chloroxymorphamine, an opioid receptor site directed ... 3H chlornaltrexamine bound complexes, possible opioid receptor components in brains of mice ... pages S153 62 year 2006 pmid 16402099 doi 10.1038 sj.bjp.0706435 pmc 1760732 ref class wikitable Receptor ... C, Sch fer M, Machelska H 2003 ref name stoppain delta Opioid receptor delta BR DOP BR OP sub 1 sub sup I sup sub 1 sub , sub 2 sub brain pons pontine nuclei amygdala olfactory bulbs deep cerebral ... kappa Opioid receptor kappa BR KOP BR OP sub 2 sub sup I sup sub 1 sub , sub 2 sub , sub 3 ... Opioid receptor mu BR MOP BR OP sub 3 sub sup I sup sub 1 sub , sub 2 sub , sub 3 sub brain ... tract GI peristalsis motility physical dependence sub 3 sub unknown Nociceptin receptor BR ... language archiveurl archivedate quote ref while the receptor was named after the mouse vas deferens tissue in which the receptor was first characterised. ref Lord JA, Waterfield AA, Hughes J, Kosterlitz HW. Nature . 1977 267 495 499. ref An additional opioid receptor was later identified and cloned ... more details
Intracellular receptors are receptor biochemistry receptor s located inside the cell biology cell rather than on its cell membrane . Examples are the class of nuclear receptor s located in the cell nucleus and the IP3 receptor IP sub 3 sub receptor located on the endoplasmic reticulum . The ligand s that bind to them are usually intracellular second messenger s like inositol trisphosphate IP sub 3 sub and extracellular lipophilicity lipophilic hormone s like steroid hormone s. Some intracrine peptide hormone s also have intracellular receptors. Members This list is mirrored on receptor biochemistry and nuclear receptor please update all simultaneously Transcription factors Steroid hormone receptor Sex hormone receptor s sex hormone s Estrogen receptor and Androgen receptor one type Vitamin D receptor vitamin D , one type Glucocorticoid receptor glucocorticoid s, one type Mineralocorticoid receptor mineralocorticoids , one type Thyroid hormone receptor and Retinoic acid receptor vitamin A and related compounds Peroxisome proliferator activated receptor s PPARs, , and Retinoid X receptor Farnesoid X receptor Liver X receptor Pregnane X receptor Constitutive androstane receptor Various Sigma 1 receptor Sigma sub 1 sub neuroactive steroid neurosteroids IP3 receptor IP sub 3 sub receptor inositol triphosphate , IP sub 3 sub See also Receptor biochemistry Receptor Steroid hormone External links http www.nuclear receptor.com Nuclear Receptor journal homepage http nrr.georgetown.edu NRR nrrhome.htm Nuclear receptor resource at Georgetown University http www.nursa.org Nuclear receptor signalling atlas NURSA, open access journal Transcription factors Cell signaling Category Intracellular receptors Intracellular receptors it Recettore intracellulare zh ... more details
site and glycine is in the glycine binding site. Allosteric sites that would cause inhibition of the receptor ... M, Betz H, and Kuhse J title Molecular determinants of antagonists discrimination by NMDA receptor ... receptor NMDAR , a glutamate receptor, is the predominant molecular device for controlling synaptic ..., 361 302, July 16, 2009 ref The NMDAR is a specific type of ionotropic glutamate receptor . NMDA N ... to ion cations with an equilibrium potential near 0 mV. A unique property of the NMDA receptor ... R, Borges K, Bowie D, Traynelis SF title The glutamate receptor ion channels journal Pharmacol ... ref ref name pmid11399431 cite journal author Cull Candy S, Brickley S, Farrant M title NMDA receptor ... P, Neyton J title NMDA receptor subunits function and pharmacology journal Curr Opin Pharmacol volume ... and memory . The NMDA receptor is distinct in two ways first, it is both Ligand gated ion ... science.2841759 ref Structure The NMDA receptor forms a heterotetramer between two NR1 and two NR2 subunits the subunits are also called glutamate binding NMDA receptor subunits or GluN for short ... A and B subunits have an inhibitory effect on receptor activity. Multiple receptor isoform s with distinct ... and differential expression of the NR2 subunits. Each receptor subunit has modular design and each ... to the channel pore and is responsible for the receptor s high unitary Electrical conductance conductance ... of NMDA receptor vertebrate and invertebrate .jpg thumb NR2 subunit in vertebrates left and invertebrates .... Evolutionary Mode and Functional Divergence of Vertebrate NMDA Receptor Subunit 2 Genes. PLoS One ... cell types and control the electrophysiological properties of the NMDA receptor. One particular subunit ... NR2 subunit lends to the receptor. ref name pmid15470155 cite journal author Liu XB, Murray KD, Jones EG title Switching of NMDA receptor 2A and 2B subunits at thalamic and cortical synapses during early ... YT title NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death ... more details
DISPLAYTITLE D sub 2 sub like receptor The D sub 2 sub like receptors are a subfamily of dopamine receptor s that bind the endogenous neurotransmitter dopamine . The D sub 2 sub like subfamily consists of three G protein coupled receptor s which are coupled to Gi alpha subunit G sub i sub G sub o sub and mediate IPSP inhibitory neurotransmission , including D2 receptor D sub 2 sub , D3 receptor D sub 3 sub , and D4 receptor D sub 4 sub . For more information, please see the respective main articles of the individual subtypes Main D2 receptor Main D3 receptor Main D4 receptor See also D1 like receptor D sub 1 sub like receptor References Reflist 2 Unreferenced date February 2010 G protein coupled receptors Cell signaling Dopaminergics Category G protein coupled receptors Category Signal transduction Category Cell signaling transmembranereceptor stub ... more details
An immune receptor or immunologic receptor is a Receptor biochemistry receptor , usually on a cell membrane , which binds to a substance for example, a cytokine and causes a response in the immune system . Types The main receptors in the immune system are pattern recognition receptors PRRs , Toll like receptor s TLRs , killer activated receptor killer activated and killer inhibitor receptor s KARs and KIRs , complement receptor s, Fc receptors , B cell receptor s and T cell receptor s. ref name Immunology20Unless Lippincott s Illustrated Reviews Immunology. Paperback 384 pages. Publisher Lippincott Williams & Wilkins July 1, 2007 . Language English. ISBN 0781795435. ISBN 978 0781795432. Page 20 ref class wikitable Comparison Receptor Bind to ref name Immunology20Unless Function ref name Immunology20Unless align left pattern recognition receptors PRRs br e.g. Toll like receptor TLRs , NOD like receptor NLRs pathogen associated molecular pattern s PAMP Mediate cytokine production inflammation destroying pathogen killer activated receptor killer activated and killer inhibitor receptor s KARs and KIRs Avails NK cells to identify abnormal host cells KAR or inhibit inappropriate host cell destruction KIR complement receptor s complement proteins on e.g. microbes Allow phagocytic and B cells to recognize microbes and immune complexes Fc receptors epitope antibody complexes Stimulate phagocytosis B cell receptor s epitope s B cell differentiation into plasma cells and proliferation T cell receptor s linear epitopes bound to major histocompatibility complex MHC Activate T cells Cytokine receptor s cytokine s regulation and co ordination of immune responses See also antigen templates at bottom References references External links MeshName immunologic receptor Transmembrane receptors Immune receptors Category Immune system nl Immuunreceptor ar ... more details
DISPLAYTITLE 5 HT sub 6 sub receptor PBB geneid 3362 The 5 HT sub 6 sub receptor is a subtype of 5 HT receptor that binds the endogenous neurotransmitter serotonin 5 hydroxytryptamine, 5 HT . ref name ... of a human 5 HT sub 6 sub serotonin receptor journal J. Neurochem. volume 66 issue 1 pages 47 56 year 1996 pmid 8522988 doi 10.1046 j.1471 4159.1996.66010047.x ref It is a G protein coupled receptor GPCR ... . ref name pmid8522988 HTR6 denotes the human gene encoding for the Receptor biochemistry receptor . ref name entrez Cite web title Entrez Gene HTR6 5 hydroxytryptamine serotonin receptor 6 url http ... The 5 HT sub 6 sub receptor is expressed almost exclusively in the brain . ref name pmid14965245 ... to, the olfactory tubercle , cerebral cortex frontal cortex frontal and Entorhinal cortex entorhinal ... al. title Cloning, characterization, and chromosomal localization of a human 5 HT6 serotonin receptor ... Cite journal author Ruat M, Traiffort E, Arrang JM, et al. title A novel rat serotonin 5 HT6 receptor ... of serotonin 5 HT6 receptor like material in the rat central nervous system journal Brain Research volume ... it can be suggested that the 5 HT sub 6 sub receptor plays a role in functions like motor control , emotionality ... Cite journal author Dawson LA, Nguyen HQ, Li P title The 5 HT 6 receptor antagonist SB 271046 selectively ... IA, Marsden CA, Fone KC title 5 HT6 receptor antagonists reverse delay dependent deficits in novel object discrimination by enhancing consolidation an effect sensitive to NMDA receptor antagonism ... ref name pmid18625457 Cite journal author Upton N, Chuang TT, Hunter AJ, Virley DJ title 5 HT6 receptor ... Neuropharmacological profile of novel and selective 5 HT6 receptor agonists WAY 181187 and WAY 208466 ... author Lacroix LP, Dawson LA, Hagan JJ, Heidbreder CA title 5 HT6 receptor antagonist SB 271046 ... has the opposite effect. ref name pmid17625499 Despite the 5 HT sub 6 sub receptor having ... Schyf CJ title Serotonin 5 HT6 receptor antagonists for the treatment of Alzheimer s disease journal ... more details
DISPLAYTITLE 5 HT sub 2A sub receptor PBB geneid 3356 The mammalian 5 HT sub 2A sub receptor is a subtype of the 5 HT sub 2 sub receptor that belongs to the serotonin receptor family and is a GPCR G protein coupled receptor GPCR . ref name pmid8035173 cite journal author Cook EH, Fletcher KE, Wainwright ... 2 sub receptor identity with frontal cortex serotonin 5 HT sub 2A sub receptor journal J. Neurochem ... url ref This is the main excitatory receptor subtype among the GPCR s for serotonin 5 HT ... exerted through 5 Ht2A receptor antagonism is dependent on increased serotonergic tone author Martin ... cortex and the orbitofrontal cortex . This receptor was given importance first as the target ... atypical ones. 5 HT sub 2A sub may be a necessary receptor for the spread of the human polyoma ... synaptic 5 HT sub 2A sub receptor is an adaptive process provoked by chronic administration of SSRIs ... Serotonin Receptor Agonists and Antagonists quote isbn 0 07 142280 3 oclc doi url accessdate ... displaced morphine, leading to naming of the 5 HT1 receptor 5 HT sub 1 sub , 5 HT2 receptor 5 HT sub 2 sub and 5 HT3 receptor 5 HT sub 3 sub receptors, corresponding to high affinity sites from LSD ... clubbed together, renaming the 5 HT sub 2 sub into 5 HT sub 2A sub . Thus the 5 HT sub 2 sub receptor ... prefrontal , parietal cortex parietal , and somatosensory cortex and the olfactory tubercle . Especially high concentrations of this receptor on the apical dendrite s of pyramidal cell s in layer V ... for thalamocortical afferents in serotonergic hallucinogen receptor function in the rat neocortex ... by a complex range of interactions with the 5 HT1A receptor 5 HT sub 1A sub , ref name pmid14754868 ... year 2004 month March pmid 14754868 doi 10.1093 cercor bhg128 url issn ref GABAA receptor GABA sub A sub ... modulate GABA A receptor channels through activation of anchored protein kinase C in prefrontal ... 11517239 doi url http www.jneurosci.org cgi content abstract 21 17 6502 issn ref Adenosine A1 receptor ... more details
DISPLAYTITLE 5 HT sub 1 sub receptor The 5 HT sub 1 sub receptors are a subfamily of 5 HT receptor s that bind the endogenous neurotransmitter serotonin 5 hydroxytryptamine, 5 HT . ref name pmid7938165 cite journal author Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP title International Union of Pharmacology classification of receptors for 5 hydroxytryptamine Serotonin journal Pharmacol. Rev. volume 46 issue 2 pages 157 203 year 1994 pmid 7938165 doi issn url http pharmrev.aspetjournals.org cgi content abstract 46 2 157 ref The 5 HT sub 1 sub subfamily consists of five G protein coupled receptor s GPCRs that are coupled to Gi alpha subunit G sub i sub G sub o sub and mediate IPSP inhibitory neurotransmission , including 5 HT1A receptor 5 HT sub 1A sub , 5 HT1B receptor 5 HT sub 1B sub , 5 HT1D receptor 5 HT sub 1D sub , 5 HT1E receptor 5 HT sub 1E sub , and 5 HT1F receptor 5 HT sub 1F sub . There is no 5 HT sub 1C sub receptor, as it was reclassified as the 5 HT2C receptor 5 HT sub 2C sub receptor . For more information, please see the respective main articles of the individual subtypes Main 5 HT1A receptor Main 5 HT1B receptor Main 5 HT1D receptor Main 5 HT1E receptor Main 5 HT1F receptor See also 5 HT2 receptor 5 HT sub 2 sub receptor References reflist G protein coupled receptors Cell signaling Serotonergics Category G protein coupled receptors Category Signal transduction Category Cell signaling hu 5 HT1 receptor ru 5 HT1 sr 5 HT1 receptor ... more details
Unreferenced stub auto yes date December 2009 Orphan date December 2009 The somatotropin receptor , or growth hormone receptor , is a member of the cytokine receptor superfamily. One growth hormone molecule binds to one Receptor biochemistry receptor and then recruits a second receptor to form a protein dimer dimer through which Cell signaling signalling occurs. Growth hormone has a Gaussian function bell shaped dose response curve because high concentrations actually prevent dimerization of the receptors and prevent signalling. DEFAULTSORT Somatotropin Receptor Category Transmembrane receptors Biochemistry stub ... more details
receptor s, whose members have certain conserved motifs in their extracellular amino acid domain. The IL 2 receptor belongs to this chain, whose chain common to several other cytokines deficiency ... II cytokine receptor s, whose members are receptors mainly for interferon s. Immunoglobulin superfamily ... of the vertebrate body Tumor necrosis factor receptor family , whose members share a cysteine rich ... and CD30 , besides the ligands on which the family is named TNF . Chemokine receptor s, two of which ... beta receptors Comparison class wikitable Type Examples Structure Mechanism type I cytokine receptor Type 1 interleukin receptors Erythropoietin receptor GM CSF receptor G CSF receptor growth hormone receptor prolactin receptor Oncostatin M receptor Leukemia inhibitory factor receptor rowspan 2 Certain ... transduction pathways type II cytokine receptor Type II interleukin receptors interferon alpha beta receptor interferon gamma receptor Many members of the immunoglobulin superfamily Interleukin 1 receptor Colony stimulating factor 1 receptor CSF1 CD117 C kit receptor Interleukin 18 receptor ... molecule s, and even some cytokines. Tumor necrosis factor receptor family CD27 CD30 CD40 CD120 Lymphotoxin beta receptor cysteine rich common extracellular binding domain chemokine receptor s Interleukin 8 receptor CCR1 CXCR4 MCAF receptor NAP 2 receptor 7TM Receptor Seven transmembrane helix G protein coupled TGF beta receptors TGF beta receptor 1 TGF beta receptor 2 Solubility Cytokine receptors ... Cytokine receptors Category Cytokine receptors membrane protein stub receptor stub cs Cytokinov receptor it Recettori accoppiati a chinasi sr Citokinski receptor sv Cytokinreceptor ... more details
DISPLAYTITLE D sub 1 sub like receptor The D sub 1 sub like receptors are a subfamily of dopamine receptor s that bind the endogenous neurotransmitter dopamine . The D sub 1 sub like subfamily consists of two G protein coupled receptor s which are coupled to G s alpha G sub s sub and mediate EPSP excitatory neurotransmission , including D1 receptor D sub 1 sub and D5 receptor D sub 5 sub . For more information, please see the respective main articles of the individual subtypes Main D1 receptor Main D5 receptor See also D2 like receptor D sub 2 sub like receptor References Reflist 2 Unreferenced date February 2010 G protein coupled receptors Cell signaling Dopaminergics Category G protein coupled receptors Category Signal transduction Category Cell signaling transmembranereceptor stub ... more details
Unreferenced date November 2006 Orphan date February 2009 A deep receptor is an element of the nervous system that is devoted to the reception of deep sensibility as opposed to tactile sensibility . A deep receptor furnishes information of what is happening in muscle , tendon s and joint s. They thus participate in proprioception . DEFAULTSORT Deep Receptor Category Nervous system Med stub ... more details
Unreferenced stub auto yes date December 2009 There are three known thrombin receptors termed PAR1 , PAR3 and PAR4 PAR for protease activated receptor . These receptors are members of the 7 transmembrane g protein coupled family of Receptor biochemistry receptor s, however, their method of activation is unique. Thrombin , a serine protease , binds to and cleaves the extracellular N terminal domain of the receptor. A tethered ligand biochemistry ligand corresponding to the new N terminus , SFLLRN, is then unmasked, binding to the second extracellular loop of the receptor and activating it. Transmembrane receptors G protein coupled receptors DEFAULTSORT Thrombin Receptor Category G protein coupled receptors Biochem stub ... more details
Multiple issues technical August 2009 expert subject September 2008 refimprove September 2008 A complement receptor is a receptor biochemistry receptor of the complement system , a part of the mediated innate immune system . Complement receptors are responsible for detecting pathogen s by mechanisms not mediated by antibody antibodies . Complement activity is not antigen sensitive, but can be triggered by specific antigens. Therefore complement a group of proteins in the serum that help achieve phagocytosis and lysis of antigens is also part of the humoral immune system . Complement receptors Types include class wikitable CR Name Cluster of differentiation CD Complement receptor 1 CR1 CD35 Complement receptor 2 CR2 CD21 CR3 Macrophage 1 antigen or integrin alphaMbeta2 CD11b CD18 CR4 Integrin alphaXbeta2 or p150,95 CD11c CD18 C3a receptor C5a receptor CD88 Clinical significance Defects in these receptors can be associated with disease. ref name urlComplement Receptor Deficiency eMedicine Dermatology cite web url http emedicine.medscape.com article 1051238 overview title Complement Receptor Deficiency eMedicine Dermatology format work accessdate 2010 12 07 ref See also Immune system References Reflist External links MeshName Complement receptors Complement system Pattern recognition receptors Use dmy dates date September 2010 DEFAULTSORT Complement Receptor Category Complement system ... more details
DISPLAYTITLE 5 HT sub 2 sub receptor The 5 HT sub 2 sub receptors are a subfamily of 5 HT receptor s that bind the endogenous neurotransmitter serotonin 5 hydroxytryptamine, 5 HT . ref name pmid7938165 cite journal author Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP title International Union of Pharmacology classification of receptors for 5 hydroxytryptamine Serotonin journal Pharmacol. Rev. volume 46 issue 2 pages 157 203 year 1994 pmid 7938165 doi url http pharmrev.aspetjournals.org cgi content abstract 46 2 157 ref The 5 HT sub 2 sub subfamily consists of three G protein coupled receptor s GPCRs which are coupled to Gq protein G sub q sub G sub 11 sub and mediate EPSP excitatory neurotransmission ref name pmid8788498 cite journal author Eison AS, Mullins UL title Regulation of central 5 HT2A receptors a review of in vivo studies journal Behavioural Brain Research volume 73 issue 1 2 pages 177 81 year 1996 pmid 8788498 doi 10.1016 0166 4328 96 00092 7 url ref , including 5 HT2A receptor 5 HT sub 2A sub , 5 HT2B receptor 5 HT sub 2B sub , and 5 HT2C receptor 5 HT sub 2C sub . For more information, please see the respective main articles of the individual subtypes Main 5 HT2A receptor Main 5 HT2B receptor Main 5 HT2C receptor See also 5 HT1 receptor 5 HT sub 1 sub receptor References reflist G protein coupled receptors Cell signaling Serotonergics Category G protein coupled receptors Category Signal transduction Category Cell signaling hu 5HT2 receptor ru 5 HT2 sr 5 HT2 receptor ... more details
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