chembox verifiedrevid 400341109 Name Oligomycin A ImageFile Oligomycin.png IUPACName 1 R ,4 E ,5 nowiki nowiki S ,6 S ,6 nowiki nowiki S ,7 R ,8 S ,10 R ,11 R ,12 S ,14 R ,15 S ,16 R ,18 E ,20 E ,22 R ,25 S ,27 R ,28 S ,29 R 22 ethyl 7,11,14,15 tetrahydroxy 6 2 R 2 hydroxypropyl 5 ,6,8,10,12,14,16,28,29 nonamethyl 3 ,4 ,5 ,6 tetrahydro 3 H ,9 H ,13 H spiro 2,26 dioxabicyclo 23.3.1 nonacosa 4,18,20 triene 27,2 pyran 3,9,13 trione IUPACName hidden yes OtherNames Oligomycin C 45 H 74 O 11 Section1 Chembox Identifiers Abbreviations ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 21106358 InChI 1S C46H76O11 c1 13 34 18 16 14 15 17 28 4 42 51 45 12,54 43 52 32 8 40 50 31 7 39 49 30 6 38 48 27 3 19 22 37 47 55 41 29 5 35 21 20 34 56 46 33 41 9 24 23 26 2 36 57 46 25 44 10,11 53 h14 16,18 19,22,26 36,38,40 42,48,50 51,53 54H,13,17,20 21,23 25H2,1 12H3 b15 14 ,18 16 ,22 19 t26 ,27 ,28 ,29 ,30 ,31 ,32 ,33 ,34 ,35?,36 ,38 ,40 ,41 ,42 ,45 ,46 m1 s1 InChIKey QBAMBSAJEFIQBK GJHUHQBXBC ... REFactor Section7 Chembox Hazards ExternalMSDS http www.fermentek.co.il MSDS oligomycin MSDS.htm ... be poisonous to other organisms. Function They have use as antibiotics . In addition, oligomycinoligomycin A? inhibits ATP synthase by blocking its proton channel Fo subunit , which is necessary ... of substrates is not enough to pump any more protons against the steep gradient. Administering oligomycinoligomycin A? to an individual can result in very high levels of lactate accumulating in the blood and urine. Fact date December 2007 Oligomycinoligomycin A? is an inhibitor of ATP synthase. In oxidative ... studies on oligomycins. Synthesis of the oligomycin B spiroketal and polypropionate portions journal ... 4 sup R sup 5 sup Oligomycin A CH sub 3 sub H OH H,H CH sub 3 sub Oligomycin B CH sub 3 sub H OH O CH sub 3 sub Oligomycin C CH sub 3 sub H H H,H CH sub 3 sub Oligomycin D br Rutamycin A H H OH H,H CH sub 3 sub Oligomycin E CH sub 3 sub OH OH O CH sub 3 sub Oligomycin F CH sub 3 sub H OH H,H CH sub ... more details
merge ATP synthase delta subunit discuss Talk THIS PAGE Merger proposal date February 2011 PBB geneid 539 ATP synthase subunit O, mitochondrial is an enzyme that in humans is encoded by the ATP5O gene . ref name entrez cite web title Entrez Gene ATP5O ATP synthase, H transporting, mitochondrial F1 complex, O subunit oligomycin sensitivity conferring protein url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 539 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The protein encoded by this gene is a component of the F type ATPase found in the mitochondrial matrix. F type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance. ref name entrez cite web title Entrez Gene ATP5O ATP synthase, H transporting, mitochondrial F1 complex, O subunit oligomycin sensitivity conferring protein url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 539 accessdate ref References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Chen H, Morris MA, Rossier C, et al. title Cloning of the cDNA for the human ATP synthase OSCP subunit ATP5O by exon trapping and mapping to chromosome 21q22.1 q22.2. journal Genomics volume 28 issue 3 pages 470 6 year 1996 pmid 7490082 doi 10.1006 geno.1995.1176 cite journal author Maruyama K, Sugano S title Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. journal Gene volume 138 issue 1 2 pages 171 4 year 1994 pmid 8125298 doi 10.1016 0378 1119 94 90802 8 cite journal author Suzuki Y, Yoshitomo Nakagawa K, Maruyama K, et al. title Construction and characterization of a full length enriched and a 5 end enriche ... more details
Pfam box Symbol OSCP Name ATP synthase delta OSCP subunit image PDB 1abv EBI.jpg width caption Structure of the N terminal domain of the delta subunit of the E. coli ATPsynthase. ref name pmid9164460 cite journal author Wilkens S, Dunn SD, Chandler J, Dahlquist FW, Capaldi RA title Solution structure of the N terminal domain of the delta subunit of the E. coli ATPsynthase journal Nat. Struct. Biol. volume 4 issue 3 pages 198 201 year 1997 month March pmid 9164460 doi 10.1038 nsb0397 198 url ref Pfam PF00213 InterPro IPR000711 SMART PROSITE PDOC00327 SCOP 1abv TCDB 3.A.2 OPM family OPM protein PDB PDB3 2a7u B 7 135 PDB3 1abv 7 106 PDB3 2bo5 A 37 143 ATP synthase delta subunit is a subunit of bacteria l and chloroplast ATPase , or OSCP oligomycin sensitivity conferral protein in mitochondrial ATPase note that in mitochondria there is a different delta subunit, InterPro IPR001469 . The OSCP delta subunit appears to be part of the peripheral stalk that holds the F1 complex alpha3beta3 catalytic core stationary against the torque of the rotating central stalk, and links subunit A of the F0 complex with the F1 complex. In mitochondria, the peripheral stalk consists of OSCP, as well as F0 components F6, B and D. In bacteria and chloroplasts the peripheral stalks have different subunit compositions delta and two copies of F0 component B bacteria , or delta and F0 components B and B chloroplasts ref name PUB00020607 cite journal author Walker JE, Runswick MJ, Neuhaus D, Montgomery MG, Carbajo RJ, Kellas FA title Structure of the F1 binding domain of the stator of bovine F1Fo ATPaseand how it binds an alpha subunit journal J. Mol. Biol. volume 351 issue 4 pages 824 838 year 2005 pmid 16045926 doi 10.1016 j.jmb.2005.06.012 ref . Human delta subunit of ATP synthase is coded by gene ATP5O . References Reflist Further reading Cite PMID 9468613 InterPro content IPR000711 DEFAULTSORT Atp Synthase Delta Subunit Category Protein domains Category Protein families Category Membrane pro ... more details
with Yasuo Kagawa. This particle was found to be sensitive to the antibiotic oligomycin ... in oxidative phosphorylation because it conferred oligomycin sensitivity on the ATPase activity complex ... more details
OSCP oligomycin sensitivity conferral protein , F6, B and D. ref name pmid16045926 cite journal author ... doi 10.1038 35185 cite journal author Webster KA, Oliver NA, Wallace DC title Assignment of an oligomycin ... more details
image Atp synthase.PNG right thumb 300px Molecular model of ATP synthase by X ray diffraction method enzyme Name atp synthase EC number 3.6.3.14 IUBMB EC number 3 6 3 14 CAS number 9000 83 3 GO code 0046961 image width caption ATP synthase EC number 3.6.3.14 is an important enzyme that provides energy for the cell to use through the synthesis of adenosine triphosphate ATP . adenosine triphosphate ATP is the most commonly used energy currency of cells from most organisms. It is formed from adenosine diphosphate ADP and inorganic phosphate P sub i sub , and needs energy . The overall reaction sequence is ATP synthase ADP P sub i sub ATP Synthase ATP Energy is often released in the form of protium or H , moving down an electrochemical gradient , such as from the lumen into the stroma of chloroplast s or from the inter membrane space into the matrix in mitochondrion mitochondria . Structure Located within the mitochondria , ATP synthase consists of 2 regions the F sub O sub portion is within the membrane. The F sub 1 sub portion of the ATP synthase is above the membrane, inside the matrix of the mitochondria. Image Mitochondrie.svg thumb 300px right Mitochondria structure 1 inner membrane, 2 outer membrane, 3 cristae, 4 matrix The nomenclature of the enzyme suffers from a long history. The F sub 1 sub fraction derives its name from the term Fraction 1 and F sub O sub written as a subscript letter o , not zero derives its name from being the oligomycin binding fraction. ref cite journal author Mccarty RE title A PLANT BIOCHEMIST S VIEW OF H ATPases AND ATP SYNTHASES journal J. Exp. Biol. volume 172 issue Pt 1 pages 431 441 year 1992 month November pmid 9874753 doi url http jeb.biologists.org cgi reprint 172 1 431 ref Oligomycin , an antibiotic, is able to inhibit the F sub O sub unit of ATP synthase. These functional regions consist of different protein subunits refer to tables. F sub 1 sub ATP Synthase structure The F sub 1 sub particle is large and can be seen in the t ... more details
Image Mitochondrial electron transport chain Etc4.svg thumb 400px The electron transport chain in the mitochondrion is the site of oxidative phosphorylation in eukaryote s. The NADH and succinate generated in the citric acid cycle are oxidized, releasing energy to power the ATP synthase . Oxidative phosphorylation or OXPHOS in short is a metabolic pathway that uses energy released by the redox oxidation of nutrient s to produce adenosine triphosphate ATP . Although the many forms of life on earth use a range of different nutrients, almost all aerobic organism s carry out oxidative phosphorylation to produce ATP, the molecule that supplies energy to metabolism . This pathway is probably so pervasive because it is a highly efficient way of releasing energy, compared to alternative fermentation biochemistry fermentation processes such as anaerobic glycolysis . During oxidative phosphorylation, electrons are transferred from reducing agent electron donors to oxidizing agent electron acceptors such as oxygen , in redox reaction s. These redox reactions release energy, which is used to form ATP. In eukaryote s, these redox reactions are carried out by a series of protein complex es within mitochondrion mitochondria , whereas, in prokaryote s, these proteins are located in the cells inner membranes. These linked sets of proteins are called electron transport chain s. In eukaryotes, five main protein complexes are involved, whereas in prokaryotes many different enzymes are present, using a variety of electron donors and acceptors. The energy released by electrons flowing through this electron transport chain is used to transport protons across the inner mitochondrial membrane , in a process called chemiosmosis . This generates potential energy in the form of a pH gradient and an Membrane potential electrical potential across this membrane. This store of energy is tapped by allowing protons to flow back across the membrane and down this gradient, through a large enzyme calle ... more details
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