other uses lowercase PBB geneid 7157 p53 also known as protein 53 or tumor protein 53 , is a tumor suppressor ... of a human p53 cDNA clone expression of the human p53 gene journal EMBO J. volume 3 issue 13 pages ... author Isobe M, Emanuel BS, Givol D, Oren M, Croce CM title Localization of gene for human p53 ... A, Jarosz D, Friedman P, Prives C, Vogelstein B title Identification of p53 as a sequence specific ... D, Givol D title The gene for human p53 cellular tumor antigen is located on chromosome 17 short arm ... pmc 322805 doi 10.1073 pnas.83.1.130 url ref p53 is crucial in multicellular organism s, where it regulates ... . As such, p53 has been described as the guardian of the genome because of its role in conserving ... 0 471 33061 2 oclc doi chapter Chapter 18 Cancer Genetics ref The name p53 is in reference to its ... from its amino acid residues, p53 s mass is actually only 43.7 kDa. This difference is due to the high ... 257 18 11176.abstract ref This effect is observed with p53 from a variety of species, including humans, rodents, frogs, and fish. Nomenclature p53 is also known as UniProt name Cellular tumor antigen p53 Antigen NY CO 13 Phosphoprotein p53 Transformation related protein 53 TRP53 Tumor suppressor p53 Gene In humans, p53 is encoded by the TP53 gene located on the short arm of chromosome 17 human chromosome ... of p53 as a sequence specific DNA binding protein journal Science volume 252 issue 5013 pages 1708 ... TP53. ref name pmid10618702 cite journal author May P, May E title Twenty years of p53 research structural and functional aspects of the p53 protein journal Oncogene volume 18 issue 53 pages 7621 36 year ... author Alawadi S, Ghabreau L, Alsaleh M, Abdulaziz Z, Rafeek M, Akil N, Alkhalaf M title P53 gene ... and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head ..., Kim HN, Song HR, Kweon SS, Choi JS, Yun WJ, Kim YC, Oh IJ, Kim KS, Shin MH title p53 codon 72 polymorphism ... study found that the p53 homozygous Pro Pro genotype was associated with a significantly increased ... more details
P53 may refer to P53 , a tumor suppressor protein P53 band , an experimental music group P53 album , a 1996 live album by experimental music group P53 disambig ... more details
Infobox album Name P53 Type live Artist P53 band P53 Cover P53 AlbumCover P53.jpg Background orange Released Startdate 1996 Recorded 1994 Genre Flatlist Experimental music Experimental free improvisation Length Duration m 44 s 08 Label Recommended Records Recommended UK Producer Chris Cutler , Lutz Glandien Last album This album P53 br 1996 Next album P53 , sometimes written p53 , is a 1996 live album by experimental music group P53 band P53 . It was their debut album and was recorded at the 25th Frankfurt Jazz Festival in Germany on nowrap 16 September 1994. It was released in 1996 in the United Kingdom by Recommended Records . ref name CD liner notes P53 was an musical improvisation al project ... ref name Cutler P53 Music The instrumentation of the P53 project consisted of two grand pianos, amplified ... name amg ref name Cutler P53 Cutler s interest in sampling music sampling and turntablism began ... interview This led to the idea of real time Sound collage montaging , which formed the basis of P53. ref name PSF Cutler interview Cutler established P53 as a free improvisation project within a predetermined ... Peter L. Herb of Wired magazine Wired magazine described P53 as a surrealist adventure that must have ... musical orthodoxy. ref name Wired Rick Anderson of Allmusic said while P53 is not the stuff ... garde scene in years. ref name amg Track listing P53 Chris Cutler Cutler , Marie Goyette Goyette ... Crossland Liner notes by Chris Cutler References reflist refs ref name CD liner notes P53 CD liner ... url yes title P53 work Allmusic first Rick last Anderson accessdate 2009 10 08 ref ref name Tokoyo ... accessdate 2009 10 08 ref ref name Cutler P53 cite web url http www.ccutler.com ccutler bands group09.shtml p53 title P53 work Chris Cutler homepage accessdate 2009 10 12 ref ref name Wired cite web url http www.wired.com wired archive 5.04 music reviews.html?pg 3 title P53 work Wired magazine Wired ... label P53 . discogs release id 1182399 name P53 . Category 1996 live albums Category 1996 debut albums ... more details
Infobox musical artist See Wikipedia WikiProject Musicians name P53 image caption background group or band ... Rose br Zeena Parkins P53 , sometimes written p53 , was an experimental music group commissioned by English ... entitled P53 album P53 . ref name CD liner notes The group reassembled in May 1997 to play at the Angelica ... 2006 a new and reduced lineup of P53 performed with the BBC Scottish Symphony Orchestra in Glasgow , Scotland, which was recorded and broadcast by the BBC in March 2007. ref name BBC P53 was an musical ... sampling processing of the pianists. ref name amg ref name Tokoyo Cutler interview ref name Cutler P53 ... before there was time to give it its name, P53 consisted of Cutler percussion, electronics , German ... . ref name CD liner notes P53 s performance at the Frankfurt Jazz Festival was filmed and later broadcast several times on German television. ref name CD liner notes An album of the concert called P53 album P53 was also released by Recommended Records in 1996. ref name japanimprov p53 In May 1997 P53, with the same lineup, performed for the second time at the Angelica International Festival of contemporary ... of P53 comprising Cutler, Australian violinist Jon Rose and American harpist Zeena Parkins , to perform ... by the BBC on 24 March 2007. ref name BBC Music main P53 album The instrumentation of the P53 ..., electronics and real time processing. ref name amg ref name Cutler P53 The pianists were instructed ... s name was taken from the p53 tumor tumour suppressing gene ref group nb name nb1 that was discovered ... harp Discography Albums P53 album P53 1996, CD, Recommended Records , United Kingdom U.K. Appears on Various artists Angelica 1997 1998, CD, Dischi di Angelica, Italy includes one P53 track Footnotes reflist group nb refs ref group nb name nb1 P53 is actually a protein encoded by the TP53 gene, but the P53 album P53 CD liner notes refer to it as a gene . ref References reflist refs ref name CD liner notes P53 album P53 CD liner notes. ref ref name PSF Cutler interview cite web url http www.furious.com ... more details
P53 family The p53 p63 p73 family is a family of tumor suppressor gene s. ref name pmid10769197 cite journal author Levrero M, De Laurenzi V, Costanzo A, Gong J, Wang JY, Melino G title The p53 p63 p73 family of transcription factors overlapping and distinct functions journal J. Cell. Sci. volume 113 issue 10 pages 1661 70 year 2000 month May pmid 10769197 doi url http jcs.biologists.org cgi pmidlookup?view long&pmid 10769197 ref ref name Finch2007 cite book author Caleb Ellicott Finch title The biology of human longevity inflammation, nutrition, and aging in the evolution of lifespans url http books.google.com books?id 4rGOLEOC4mEC&pg PA350 accessdate 23 December 2010 year 2007 publisher Academic Press isbn 9780123736574 pages 350 ref It consists of p53 TP73L also known as p63 p73 They are sometimes considered part of a p53 family . ref name pmid18627398 cite journal author Chen S, Moroi Y, Urabe K, et al. title Differential expression of two new members of the p53 family, p63 and p73, in extramammary Paget s disease journal Clin. Exp. Dermatol. volume 33 issue 5 pages 634 40 year 2008 month July pmid 18627398 doi 10.1111 j.1365 2230.2008.02851.x ref Evolution of the p53 family P53, p63, and p73 have similar features in their gene structures and functions but have also diverged evolutionarily. The p53 family evolved from a p63 p73 ancestor gene in invertebrates. ref name Levine et al. 2010 cite journal author Levine, A. J., V. A. Belyi, P. Ak, E. Markert, H. J. Wang, W. W. Hu, and A. Puzio Kuter. title The origins and evolution of the p53 family of genes journal Cold Spring Harbor Perspectives in Biology volume 2 year 2010 ref P53 diverged from p63 p73 with a gene duplication in the cartilaginous fish. ref name Levine et al. 2010 ref P63 and p73 differentiated from each other in bony fish. ref name Levine et al. 2010 ref . These genes developed different functions and structures throughout their evolutionary divergence TP73L , p73 , p53 . References reflist Tumor suppressor ... more details
Lowercase title PBB geneid 27113 The p53 upregulated modulator of apoptosis PUMA also known as Bcl 2 ..., is induced by p53 journal Mol. Cell volume 7 issue 3 pages 683 94 year 2001 month March pmid 11463392 ... suppressor p53 . PUMA is involved in p53 dependent and independent apoptosis induced by a variety ... p53 journal Oncogene volume 27 Suppl 1 issue pages S71 83 year 2008 month December pmid 19641508 pmc ... from the p53 inducible BH3 only proteins Noxa and Puma in complex with Mcl 1 journal J. Mol. Biol ... PUMA mediates the apoptotic response to p53 in colorectal cancer cells journal Proc. Natl. Acad. Sci ... title PUMA, a novel proapoptotic gene, is induced by p53 journal Mol. Cell volume 7 issue 3 pages 683 ..., Qiu W, Wang P, Yu H, Cheng T, Zambetti GP, Zhang L, Yu J title p53 independent induction of PUMA mediates ... activation of the tumor suppressor protein p53 . p53 is activated by survival signals such as glucose ..., Cui K, Rathmell JC title Glucose metabolism attenuates p53 and Puma dependent cell death upon growth ... dysfunction . p53, and with it PUMA, is activated due to DNA damage caused by a variety of genotoxicity genotoxic agents . Other agents that induce p53 dependent apoptosis are neurotoxins , ref ... J title Activation of p53 and the pro apoptotic p53 target gene PUMA during depolarization induced ... exclusive subsets of BH3 only proteins are activated by the p53 and c Jun N terminal kinase c ..., Fojo T title Enhanced microtubule dependent trafficking and p53 nuclear accumulation by suppression ... be induced independently of p53 activation by other stimuli, such as oncogenic stress ref name pmid12695333 ..., Perfettini JL, Piacentini M, Kroemer G title p53 A pro apoptotic signal transducer involved in AIDS ..., many human tumors contain p53 mutations , ref name pmid15286780 cite journal author Vogelstein ... pmid15865941 cite journal author Yu J, Zhang L title The transcriptional targets of p53 in apoptosis ... 10.1016 j.dld.2006.11.006 ref Many cancers do exhibit p53 gene mutations, making gene therapies that target ... more details
Infobox Ship Begin Infobox Ship Image Ship image Ship caption Infobox Ship Career Hide header Ship country Ship flag Navy IND Ship name INS Savitri Ship namesake Ship ordered Ship builder Hindustan Shipyard Limited Ship laid down Ship launched 23 May 1989 Ship acquired Ship commissioned 27 November 1990 Ship decommissioned Ship in service Ship out of service Ship struck Ship reinstated Ship honours Ship fate Ship status Active Ship notes Infobox Ship Characteristics Hide header Header caption Ship class Sukanya class patrol vessel ref name in sukanya http www.indiannavy.nic.in opv sukanya.htm ref Ship type Ship tonnage Ship displacement 1,890 tons full load ref name in sukanya http indiannavy.nic.in opv sukanya.htm ref Ship tons burthen Ship length 101 metres Ship beam 11.5 metres Ship height Ship draught Ship draft Ship depth Ship hold depth Ship decks Ship deck clearance Ship ramps Ship ice class Ship power Ship propulsion 2 diesel engine s, convert 12800 bhp kW 1 abbr on , 2 shafts Ship sail plan Ship speed convert 21 kn km h 0 Ship range convert 7000 nmi km 3 at convert 15 kn km h 0 Ship endurance Ship test depth Ship boats Ship capacity Ship troops Ship complement 70 Ship crew Ship time to activate Ship sensors 1 x Racal Decca 2459 search radar br 1 BEL 1245 navigation radar Ship EW Ship armament 1 x 40 mm, 60 cal Bofors anti aircraft gun br 2 x 12.7 mm machine guns br P51 added 1 Dhanush missile Dhanush ballistic missile br P55 added 2 x 25 mm, 80 cal anti aircraft guns Ship armour Ship armor Ship aircraft 1 HAL Chetak Ship aircraft facilities Ship notes INS Savitri P53 is a Sukanya class patrol vessel of the Indian Navy . ref name in sukanya References references Ship classes of the Indian Navy DEFAULTSORT Savitri P53 Category Sukanya class patrol vessels Category Patrol vessels of the Indian Navy Category Active naval ships of India india mil stub mil ship stub ... more details
AmpliChip is a family of clinical tests from the Swiss healthcare company Hoffmann La Roche which aim to find out the patients genotype using micro array technology. The tests include CYP450 Test and P53 Test. The CYP450 Test was approved by the United State s Food and Drug Administration FDA . AmpliChip CYP450 Test AmpliChip P53 Test disambig Category Microarrays ... more details
17P or 17.P may refer to 17P Holmes , a comet SpaceShipOne flight 17P , a commercial spaceflight 17 Hydroxyprogesterone , a medication to prevent pre term labor 17p, the short arm of the Chromosome 17 human 17th human chromosome that has the p53 tumour suppressor gene See also P17 disambiguation Letter NumberCombDisambig de 17P ... more details
orphan date December 2008 Adenovirus E1B protein usually refers to one of two proteins Transcription genetics transcribed from the E1B gene of the adenovirus a 55kDa protein and a 19kDa protein. Primarily, the two work to delay cell lysis during viral replication. Afterwards, they help induce cell death and control the export of viral transcripts. Specifically, the E1B 55kDa protein inhibits p53 acetylation, and therefor activation, by PCAF 1 . See also Adenoviridae References 1. Yue Liu, April L. Colosimo, Xiang Jiao Yang, and Daiqing Liao 2000 . Adenovirus E1B 55 Kilodalton Oncoprotein Inhibits p53 Acetylation by PCAF . Molecular and Cellular Biology Vol 20 p5540 5553. Category Proteins genetics stub ... more details
Orphan date February 2009 Siva protein is a novel zinc containing intracellular ligand of the CD4 sensory receptor receptor that promotes HIV 1 envelope induced apoptosis in T lymphoid cells. Recent research has demonstrated that Siva is a direct transcriptional target for the tumor suppressors p53 and E2F1. ref cite journal author Fortin A, MacLaurin JG, Arbour N, et al. title The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1 journal J. Biol. Chem. volume 279 issue 27 pages 28706 14 year 2004 month July pmid 15105421 doi 10.1074 jbc.M400376200 url http www.jbc.org cgi pmidlookup?view long&pmid 15105421 ref References reflist Category Proteins biochem stub ... more details
p53 Protein Protein Interaction to Reactivate p53 Function A Novel Approach for Cancer Therapy ... annurev.pharmtox.48.113006.094723 pmc 2676449 ref . Inhibiting the interaction between mdm2 and p53 stabilizes p53 and is thought to selectively induce a growth inhibiting state called senescence ... or wild type p53. Citation needed date April 2011 Nutlin 3 has been shown to affect the production of p53 within minutes. ref name Leeuwen et al. Cite journal work Cell Cycle publisher Landes Bioscience title Mechanism specific signatures for small molecule p53 activators volume 10 issue 10 date 15 ... of Nutlin 3, a potent p53 MDM2 inhibitor. Chemical Science. The Royal Society of Chemistry ... more details
Gendicine is a recombinant adenovirus engineered to express wildtype p53 rAd p53 . This virus is designed to treat patients with tumors which have mutated p53 genes. Gendicine is the first gene therapy product approved for clinical use in humans. Gendicine is manufactured by Shenzhen SiBiono GeneTech . Gendicine was approved by the Chinese SFDA State Food and Drug Administration to treat head and neck squamous cell carcinoma and various forms of cancer. ref name nature Cite web url http www.nature.com nbt journal v22 n1 full nbt0104 3.html title China approves first gene therapy Article Nature Biotechnology work nature.com accessdate February 24, 2010 ref References Reflist Category Gene delivery Category Viruses Genetics stub de Gendicine ... more details
cell by binding to and degrading the p53 transcription factors, ref cite doi 10.1038 357082a0 ... with Onyx 015 are incapable of blocking p53 s function. If Onyx 015 infects a wildtype normal cell, with a functioning p53 gene, it will be prevented from multiplying by the action of the p53 transcription factor. However if Onyx 015 infects a p53 deficient cell it should be able to survive and replicate ... more details
gene, inhibits p53 mediated apoptosis of splenic B cells. ref name Xin Xin H. et al. Increased expression of Ifi202, an IFN activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53 mediated ... fibroblasts of mice. Since it is known that p53 mediates the expression of proapoptotic proteins, the increased p202 correlates with increased p53 levels. p202 seems to bind to p53 protein at the N terminal region, and important to inhibits p53 function. ref name Xin Interestingly, p53 expression ... light, while p53 levels increased. The overexpression of p202 in cells decreased the p53 mediated ... negative regulator of the p53 tumor suppressor, is a target of p53 mediated transcriptional repression ... more details
lowercase title p53 PBB geneid 7161 p73 is a protein related to the p53 tumor protein. Because of its structural resemblance to p53, it has also been considered a tumor suppressor gene tumor suppressor . It is involved in cell cycle regulation, and induction of apoptosis . Like p53, p73 is characterized by the presence of different isoforms of the protein. This is explained by splice variant s, and an alternative promoter biology promoter in the DNA sequence. p73, also known as tumor protein 73 TP73 , protein was the first identified homologue of the tumor suppressor gene, p53. Like p53, p73 has ... suppressor p53. The over expression of p73 in cultured cells promotes a growth arrest and or apoptosis similarly to p53. The p73 gene has been mapped to a chromosome region 1p36. 2 3 a locus commonly deleted in various tumor entities and human cancers. Similar to p53 the protein product of p73 induces ... deficient mice do not show a tumorigenic phenotype. A deficiency of p53 almost certainly leads ... a role in tumorigenesis. Genes of the p53 family are known to be complex. The viral oncoproteins e.g. Adenovirus E1B that efficiently inhibit p53 function are unable to inactivate p73, and those that seem to inhibit p73 have no effect on p53. Debate persists about the exact function of p73. Recently ... function of p53. This strongly implicates p73 as playing a large role in cellular differentiation ... occurring p73 mutation in a p73 p53 double mutant lung cancer cell line encodes p73 protein with a dominant ... gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers ... A, Gong J, Wang JY, Melino G title The p53 p63 p73 family of transcription factors overlapping ... title An anti apoptotic role for the p53 family member, p73, during developmental neuron death journal ... 10.1038 35003607 PBB Further reading citations cite journal author Kaelin WG title The emerging p53 ... Jacobs WB, Walsh GS, Miller FD title Neuronal survival and p73 p63 p53 a family affair. journal The Neuroscientist ... more details
Orphan date February 2009 PBB geneid 23368 Apoptosis stimulating of p53 protein 1 is a protein that in humans is encoded by the PPP1R13B gene . ref name pmid9872452 cite journal author Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O title Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro journal DNA Res volume 5 issue 5 pages 277 86 year 1999 month Apr pmid 9872452 pmc doi 10.1093 dnares 5.5.277 ref ref name entrez cite web title Entrez Gene PPP1R13B protein phosphatase 1, regulatory inhibitor subunit 13B url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 23368 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text This gene encodes a member of the ASPP apoptosis stimulating protein of p53 family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein protein interactions. ASPP proteins are required for the induction of apoptosis by p53 family proteins. They promote DNA binding and transactivation of p53 family proteins on the promoters ... author Liu ZJ, Lu X, Zhong S title ASPP Apoptotic specific regulator of p53. journal Biochim. Biophys ... stimulate the apoptotic function of p53. journal Mol. Cell volume 8 issue 4 pages 781 94 year 2001 ... journal author Bergamaschi D, Samuels Y, Jin B, et al. title ASPP1 and ASPP2 common activators of p53 ... Hershko T, Chaussepied M, Oren M, Ginsberg D title Novel link between E2F and p53 proapoptotic cofactors of p53 are transcriptionally upregulated by E2F. journal Cell Death Differ. volume 12 issue ... of the 5 untranslated region in cancer cell lines retaining wild type p53. journal ... and ASPP2 from stimulating p53 without targeting p53 for degradation. journal Oncogene volume 24 issue ... more details
PBB geneid 4193 Mdm2 is an important negative regulator of the p53 tumor suppressor. It is the name of a gene ... E3 ubiquitin ligase that recognizes the N terminal trans activation domain TAD of the p53 tumor suppressor and an inhibitor of p53 transcriptional activation. Discovery and expression in tumor cells ... also called MdmX , has been discovered and is also an important negative regulator of p53 . Ubiquitination target p53 The key target of Mdm2 is the p53 tumor suppressor. Mdm2 has been identified as a p53 interacting protein that represses p53 transcriptional activity. Mdm2 achieves this repression by binding to and blocking the N terminal trans activation domain of p53. Mdm2 is a p53 responsive gene that is, its transcription can be activated by p53. Thus when p53 is stabilized, the transcription ... as an Ubiquitin ligase E3 ubiquitin ligase , targeting both itself and p53 for degradation by the proteasome see also Ubiquitin . Several lysine residues in p53 C terminus have been identified as the sites of ubiquitination, and it has been shown that p53 protein levels are downregulated by Mdm2 in a proteasome ..., a cooperating Ubiquitin ligase E3 ubiquitin ligase , is capable of polyubiquitinating p53. In this manner, Mdm2 and p53 are the members of a negative feedback control loop that keeps the level of p53 low in the absence of p53 stabilizing signals. This loop can be interfered with by kinases and genes like p14arf when p53 activation signals, including DNA damage, are high. Structure and function ... terminal p53 interaction domain, the structure of which has been solved using x ray crystallography ... in protein function and stabilization of p53 . Additionally, phosphorylation at certain residues within the central acidic domain of Mdm2 may stimulate its ability to target p53 for degradation. The induction ... a mechanism of negatively regulating the p53 Mdm2 interaction. p14arf directly interacts with Mdm2 and leads to up regulation of p53 transcriptional response. ARF sequesters Mdm2 in the nucleolus ... more details
. She is known for her work on the tumor suppressor tumour suppressor protein, p53 , and in particular ... tumor suppressor tumour suppressor protein p53 in vivo , resulting in its degradation. ref Lechner MS, Mack DH, Finicle AB, et al. . 1992 Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53 mediated repression of transcription EMBO J 11 3045 3052 ref p53 Vousden s recent research has centered on p53 . ref name Royal Soc news Sometimes called the guardian of the genome , p53 plays ... in the apoptosis pathway triggered by p53, the protein P53 upregulated modulator of apoptosis PUMA P53 ..., is induced by p53 Mol Cell 7 683 694 ref ref Yu J, Zhang L. 2003 No PUMA, no death implications for p53 dependent apoptosis. Cancer Cell 4 248 249 ref Image Mdm2.png thumb right 120px Structure of Mdm2 To prevent it being activated inappropriately, p53 is strictly controlled in the normal cell. Vousden ..., she showed that Mdm2 is a ubiquitin ligase which targets p53 for degradation by the proteasome ... ref Kubbutat MHG, Jones SN, Vousden KH. 1997 Regulation of p53 stability by Mdm2 Nature 387 299 ... protein ligase for itself and p53 J Biol Chem 275 8945 8951 ref Reactivating p53 can inhibit the growth ... of p53 in cells Bioorg Med Chem 15 77 86 ref Mdm2 inhibitors have also been discovered by researchers ... p53 can also help to prevent or repair minor damage to the genome under conditions of low stress. Vousden s group have recently discovered a novel p53 regulated protein, TIGAR T p53 Inducible Glycolysis ... of p53. ref Bensaad K, Tsuruta A, Selak MA, et al. . 2006 TIGAR, a p53 inducible regulator ... publications Reviews and books Yee KS, Vousden KH. 2005 Complicating the complexity of p53 Carcinogenesis ... G, Black F, et al. . 2007 Synthesis of 5 deazaflavin derivatives and their activation of p53 in cells Bioorg Med Chem 15 77 86 PMID 17064912 Bensaad K, Tsuruta A, Selak MA, et al. . 2006 TIGAR, a p53 ... 16839880 Nakano K, Vousden KH. 2001 PUMA, a novel proapoptotic gene, is induced by p53 Mol Cell ... more details
PBB geneid 7159 Apoptosis stimulating of p53 protein 2 ASPP2 also known as Bcl2 binding protein Bbp and tumor suppressor p53 binding protein 2 p53BP2 is a protein that in humans is encoded by the TP53BP2 gene . ref name pmid8668206 cite journal author Naumovski L, Cleary ML title The p53 binding protein ... that bind to wild type but not mutant p53 journal Proc Natl Acad Sci U S A volume 91 issue 13 pages ... cite web title Entrez Gene TP53BP2 tumor protein p53 binding protein, 2 url http www.ncbi.nlm.nih.gov ... amino acid residues 600 1128 was initially identified as 53BP2 p53 binding protein 2 in a yeast two hybrid screen using p53 as the bait. ref name pmid8016121 cite journal author Iwabuchi K, Bartel PL, Li B, Marraccino R, Fields S title Two cellular proteins that bind to wild type but not mutant p53 ... the apoptotic function of p53 journal Mol Cell Biol. volume 8 issue 4 pages 781 94 year 2001 month ... specifically stimulate the apoptotic function of p53 journal Mol Cell Biol. volume 8 issue 4 pages ... binds to wild type p53 but fails to bind to mutant p53 , suggesting that ASPP2 may be involved in the ability of wild type p53 to suppress transformation genetics transformation . ref name pmid8016121 ... between aa 123 and 323. ref name pmid8668206 cite journal author Naumovski L, Cleary ML title The p53 ... author Naumovski L, Cleary ML title The p53 binding protein 53BP2 also interacts with Bc12 and impedes ... ref name pmid8875926 cite journal author Gorina S, Pavletich NP title Structure of the p53 tumor ... specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53 binding protein 2 and translocates .... The name ASPP stands for apoptosis stimulating protein of p53, the name emphasizes the ankyrin repeats ... of p53 journal Mol Cell Biol. volume 8 issue 4 pages 781 94 year 2001 month October pmid 11684014 doi ... stimulate the apoptotic function of p53 journal Mol Cell Biol. volume 8 issue 4 pages 781 ... C terminus was first known to bind to p53 through its ankyrin repeats and SH3 domain in 1994 by a yeast ... more details
from the 5 arm of the stem loop hairpin . The mature miR 34a is a part of the p53 tumor suppressor ... L, He X, Lim LP, et al title A microRNA component of the p53 tumour suppressor network journal Nature ... pmc 2533205 ref miR 34 inhibition of SIRT1 leads to an increase in acetylated p53 and expression of p21 and PUMA, transcriptional targets of p53 that regulate the cell cycle and apoptosis, respectively ... but not in human colon cancer cells lacking p53. Finally, miR 34a itself is a transcriptional target of p53, suggesting a positive feedback loop between p53 and miR 34a. Thus, miR 34a functions as a tumor suppressor, in part, through a SIRT1 p53 pathway. ref name pmid18755897 Mir 34 inhibits human p53 mutant gastric cancer tumorspheres p53 deficient human gastric cancer cells, restoration of functional ... 34 may restore p53 function. Restoration of miR 34 inhibits tumorsphere formation and growth, which ... al. Restoration of tumor suppressor miR 34 inhibits human p53 mutant gastric cancer tumorspheres. BMC ... fig1.jpg Mir 34 and p53 pathway ref References reflist 1 External links Rfam id RF00456 name mir 34 ... more details
MedalTableTop MedalSport Track and field P53 MedalCountry NZL MedalCompetition Paralympic Games MedalGold 2000 Summer Paralympics 2000 Sydney Athletics at the 2000 Summer Paralympics Men s Pentathlon P53 Pentathlon P53 MedalGold 1992 Summer Paralympics 1992 Barcelona Athletics at the 1992 Summer Paralympics Men s Javelin throw F52 JT F52 MedalSilver 1996 Summer Paralympics 1996 Atlanta Athletics at the 1996 Summer Paralympics Men s Javelin throw F51 JT F51 MedalBottom David McCalman is a Paralympian Track and field athlete from New Zealand competing mainly in category P53 pentathlon events. He competed in the 1992 Summer Paralympics in Barcelona , Spain . There he finished fourth in the men s Shot putt THW2 event, finished fifth in the men s Javelin throw THW2 event, finished twelve in the men s Discus throw THW2 3 event, finished seventh in the men s 200 metres TW2 event and went out in the first round of the men s 800 metres TW2 event. He also competed at the 1996 Summer Paralympics in Atlanta , United States . There he won a silver medal in the men s Javelin throw F51 event and finished sixth in the men s Shot putt F51 event. He also competed at the 2000 Summer Paralympics in Sydney , Australia . There he won a gold medal in the men s Pentathlon P53 event, a gold medal in the men s Javelin throw F52 event and finished fourth in the men s Shot putt F52 event. He also competed at the 2004 Summer Paralympics in Atlanta , United States . There he finished twelve in the men s Javelin throw F52 53 event and finished ninth in the men s Shot putt F52 event External links IPC profile surname MacCalman givenname David Persondata Metadata see Wikipedia Persondata . NAME Maccalman, David ALTERNATIVE NAMES SHORT DESCRIPTION New Zealand paralympic athlete DATE OF BIRTH PLACE OF BIRTH DATE OF DEATH PLACE OF DEATH DEFAULTSORT Maccalman, David Category Paralympic athletes of New Zealand Category Athletes track and field at the 1992 Summer Paralympics Category Athletes track and field ... more details
A. last4 Kelley first4 A. R. last5 Tuttle first5 R. last6 Berberich first6 S. J. title YPEL3, a p53 ... Source1 Initially discovered in a gene expression profiling assay of p53 activated MCF7 cells, ref name ... following HdmX or Hdm2 knockdown in human tumor cells harboring wild type p53 journal Aging volume ... were discovered during experiments to investigate p53 dependent cell cycle arrest. While investigating the p53 tumor suppressor protein, microarray studies which targeted Hdmx and Mdm2 Hdm2 , both p53 negative regulators, revealed YPEL3 as a potential p53 regulated gene in MCF7 breast cancer cells .... ref name Source3 Biological Function YPEL3 and p53p53 is a tumor suppressor protein encoded by the human gene TP53 whose function is to prevent unregulated cell growth. p53 can be activated in response ... in a complex pathway, activated p53 has been shown to bind DNA and transcriptionally regulate genes ... Oren first2 Moshe title The first 30 years of p53 growing ever more complex journal Nature Reviews ... of functioning p53 in the regulation of the cell cycle is evident in that 55 of human cancers exhibit p53 mutations. ref cite journal last1 Hollstein first1 M last2 Sidransky first2 D last3 Vogelstein first3 B last4 Harris first4 C. title P53 mutations in human cancers journal Science volume ... to be a possible p53 target after a screen for such genes was performed in MCF7 breast cancer cells following RNAi knockdown of p53 negative inhibitors. ref name Source2 In both human normal and tumor cell lines, YPEL3 has been shown to be a p53 inducible gene. Two putative p53 binding sites ... biology promoter . ref name Source1 YPEL3 and Cellular Senescence As a part of the p53 pathway response .... last9 Weissleder first9 Ralph title Restoration of p53 function leads to tumour regression in vivo ... more details
Orphan date April 2012 Image Gankyrin.png thumb 200px Structure of gankyrin PDB ID 1OUH , illustrating helical ankyrin repeats. Gankyrin is a recently discovered oncogene oncoprotein that is a component of the 19S regulatory cap of the proteasome . Structurally, it contains a 33 amino acid ankyrin repeat that forms a series of alpha helix alpha helices . ref name KrzywdaStructure Krzywda S, Brzozowski AM, Higashitsuji H, Fujita J, Welchman R, Dawson S, Mayer RJ, Wilkinson AJ. 2004 . The crystal structure of gankyrin, an oncoprotein found in complexes with cyclin dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53. J Biol Chem 279 2 1541 5. ref It plays a key role in regulating the cell cycle via protein protein interaction s with the cyclin dependent kinase CDK4. It also binds closely to the E3 ubiquitin ligase MDM2 , which is a regulator of the degradation of p53 and retinoblastoma protein , both transcription factor s involved in tumor suppressor tumor suppression and found mutated in many cancer s. ref name Krzywda Krzywda S, Brzozowski AM, Al Safty R, Welchman R, Mee M, Dawson S, Fujita J, Higashitsuji H, Mayer RJ, Wilkinson AJ. 2003 . Crystallization of gankyrin, an oncoprotein that interacts with CDK4 and the S6b rpt3 ATPase of the 19S regulator of the 26S proteasome. Acta Crystallogr D Biol Crystallogr 59 Pt 7 1294 5. ref Gankyrin also has an anti apoptosis apoptotic effect and is overexpressed in certain types of tumor cells such as hepatocellular carcinoma . ref name Higashitsuji Higashitsuji H, Liu Y, Mayer RJ, Fujita J. 2005 . The oncoprotein gankyrin negatively regulates both p53 and RB by enhancing proteasomal degradation. Cell Cycle 4 10 1335 7. ref References references External links MeshName gankyrin protein, human Category Proteins protein stub ... more details
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