Infobox disease Name Pertussis Image Pertussis.jpg Caption A young boy coughing due to pertussis. DiseasesDB ... 394 eMedicine mult eMedicine2 ped 1778 MeshID D01491 Pertussis , also known as whooping ... disease caused by Bordetella pertussis . In some countries, this disease is called the 100 days ... of Bordetella pertussis infection and disease journal Curr Opin Pharmacol volume 7 issue 3 ... deaths. ref name Cochrane2010 Signs and symptoms The classic signs of pertussis are a paroxysmal ... have pertussis? journal JAMA volume 304 issue 8 pages 890 6 year 2010 month August pmid 20736473 doi 10.1001 jama.2010.1181 ref The cough from pertussis has been documented to cause subconjunctival ... whooping sound on coughing, the likelihood that the illness is pertussis is nearly doubled ... pertussis Methods used in laboratory diagnosis include microbiological culture culturing of nasopharyngeal ... into their illness, serology may be used to determine whether antibody against pertussis toxin or another component of B. pertussis is present at high levels in the blood of the patient. By this stage ... of this, adults, who are not in great danger from pertussis, are increasingly being encouraged to be vaccinated ... The primary method of prevention for pertussis is vaccination . There is insufficient evidence to determine ..., J title Antibiotics for whooping cough pertussis . journal Cochrane database of systematic reviews ... risk of severe disease such as infants . ref name Update10 Vaccine Pertussis vaccine s are effective ... Annex 6 whole cell pertussis url http www.who.int biologicals publications trs areas vaccines whole cell pertussis Annex 206 20whole 20cell 20pertussis.pdf work World Health Organization accessdate ... Pertussis Summary of Vaccine Recommendations url http www.cdc.gov vaccines vpd vac pertussis recs ... half a million lives in 2002. ref name WHO2007Vac The multi component acellular pertussis vaccine ... of greatest exposure and greatest risk of death from pertussis. ref name JAMA2010 ref cite ... more details
italic title Taxobox name Bordetella pertussis image Bordetella pertussis.jpg image width 240px image ... Alcaligenaceae genus Bordetella species B. pertussis binomial Bordetella pertussis binomial authority Bergey et al. 1923 br Moreno L pez 1952 Bordetella pertussis is a Gram negative , Aerobic organism aerobic coccobacillus capsulate of the genus Bordetella , and the causative agent of pertussis or whooping cough. Unlike Bordetella bronchiseptica B. bronchiseptica , B. pertussis is non motile . Its virulence factors include pertussis toxin , Filamentous haemagglutinin adhesin filamentous h magglutinin ... to be a zoonotic reservoir for B. pertussis &mdash humans are its only Host biology host . The bacterium is spread by airborne droplets its incubation period is seven to 14 days. PertussisPertussis ... died from pertussis. Worldwide in 2000, according to the WHO, around 39 million people were infected ... vaccination in England. ref name urlHPA Whooping Cough Pertussis cite web url http www.hpa.org.uk ... title HPA Whooping Cough Pertussis format work accessdate 2009 04 12 ref Bordetella pertussis infects .... These coughs expel some bacteria into the air, which are free to infect other hosts. B. pertussis has the ability to inhibit the function of the host s immune system. The toxin, known as pertussis ..., or laughs. Pertussis vaccine is part of the diphtheria , tetanus , and acellular pertussis DTaP immunization . The paroxysmal cough precedes a crowing inspiratory sound characteristic of pertussis .... This is because B. pertussis inhibits the immune response, so very little mucus is generated in the lungs ... pertussis.html title Bordetella pertussis and Whooping Cough author Kenneth ... External links http www.who.int immunization topics pertussis en index1.html Pertussis Information ... pertussis.html Bordetella pertussis in ARUP Consult The Physician s Guide to Laboratory Test Selection and Interpretation http www.hpa.org.uk infections topics az whoopingcough gen info.htm Pertussis ... more details
pertussis infection journal Drugs volume 52 month Aug pages 254 275 year 1996 pmid 8841742 issue 2 ref ... and diphtheria toxoids with acellular pertussis Tdap vaccine. These vaccines are the first acellular pertussis containing vaccines that make it possible to vaccinate adolescents and adults against pertussis. ref http www.vaccineinformation.org pertuss qandavax.asp ref All people need protection against these three diseases diphtheria, tetanus, and pertussis. Routine booster doses are also ... pertussis vaccine efficacy range from 80 to 85 a level believed to be far more efficacious than the previously used whole cell pertussis vaccine. ref http www.vaccineinformation.org pertuss ... more details
Pfam box Symbol Pertussis S1 Name Pertussis toxin, subunit 1 image 1PRT.png width caption The Crystal Structure of Pertussis Toxin, ref name pmid8075982 cite journal author Stein PE, Boodhoo A, Armstrong GD, Cockle SA, Klein MH, Read RJ title The crystal structure of pertussis toxin journal Structure ... Symbol Pertussis S2S3 Name Pertussis toxin, subunit 2 and 3 image width caption Pfam PF02918 InterPro ... Pertussis toxin, subunit 4 image width caption Pfam PF09275 InterPro IPR015355 SMART Prosite SCOP 1prt TCDB OPM family OPM protein Pfam box Symbol Pertus S5 tox Name Pertussis toxin, subunit 5 image width caption Pfam PF09276 InterPro IPR015356 SMART Prosite SCOP 1prt TCDB OPM family OPM protein Pertussis ... pertussis , ref name Sherris cite book author Ryan KJ Ray CG editors title Sherris Medical .... ref cite journal author Carbonetti NH, Artamonova GV, Mays RM, Worthington ZE title Pertussis Toxin Plays an Early Role in Respiratory Tract Colonization by Bordetella pertussis journal Infect ..., ref name Kost 1999 cite journal author Kost C, Herzer W, Li P, Jackson E title Pertussis ..., Pushkarsky T, Poli G, Bukrinsky M title The B Oligomer of Pertussis Toxin Inhibits Human Immunodeficiency .... ref name Bagley cite journal author Bagley K, Abdelwahab S, Tuskan R, Fouts T, Lewis G title Pertussis toxin and the adenylate cyclase toxin from Bordetella pertussis activate human monocyte derived ... journal author Locht C, Keith JM title Pertussis toxin gene nucleotide sequence and genetic organization ..., Casagli MC, Borri MG, Antoni G, Almoni M, Neri P, Ratti G title Cloning and sequencing of the pertussis ... PT clearly plays a central role in the pathogenesis of pertussis , as this was discovered only in the early 1980s. The appearance of pertussis is quite recent, compared with other epidemic infectious diseases. The earliest mention of pertussis, or whooping cough , is of an outbreak in Paris in 1414. This was published in Moulton s The Mirror of Health, in 1640. Another epidemic of pertussis took ... more details
Unreferenced date August 2009 Pfam box Symbol Name Pertactin image width 200 px caption Pfam PF03212 InterPro IPR004899 SMART Prosite PDOC00271 SCOP 1dab TCDB OPM family OPM protein Pertactin PRN is a highly immunogenic Virulence virulence factor of Bordetella pertussis , a bacterium that causes pertussis . Specifically, it is an outer membrane protein that promotes Cell adhesion adhesion to Vertebrate trachea trachea l epithelial cell s. PRN is purified from Bordetella pertussis and is used for the vaccine production as one of the important components of acellular pertussis vaccine. Citation needed date August 2009 Pertactin domains are common components of the excreted portion of bacterial Autotransporter domain autotransporter proteins. The domain is made up of a beta helix of variable length. Category Microbiology biochem stub de Pertactin es Pertactina ... more details
File Babyimmunization.jpg thumb 150px This Bangladesh i infant was being immunized, but cocooning would also involve vaccinating the mother and other close family members File HumanNewborn.JPG thumb 250px An infant has very little Immunity medical immunity to virus es Cocooning , also known as the Cocoon Strategy , ref name texas childrens cite web url http www.texaschildrens.org carecenters vaccine programs.aspx title The Cocoon Strategy Preventing Severe and Fatal Pertussis Whooping Cough in Infants Through Family Immunization publisher Texas Children s Hospital date accessdate ref is a vaccination strategy that has been recommended by the Centers for Disease Control and Prevention CDC in the United States since 2006. It aims to protect newborn infants from becoming infected with pertussis by administering DTaP tetanus, diphtheria and acellular pertussis booster vaccine to mothers, family members and any individuals who would come into regular contact with the newborn infant. By vaccinating these individuals with a pertussis booster a pool of persons is established around the newborn who are themselves protected from getting pertussis and passing it on to the young infant, thereby creating a cocoon of protection around the newborn. Young infants have the highest rate of pertussis in 87 100 of all deaths caused by pertussis, the victim is an infant of less than 6 months of age. ref name texas childrens Definition blockquote The concept of cocooning is simple. A Infant newborn baby has little if any Immunity medical immunity to influenza for the first 12 months of life. To ensure protection for the baby, immediate household contacts representing its cocoon are vaccinated against influenza so they won t transmit the virus to the baby. The program began in July 2006 with pertussis vaccination and it now includes seasonal Influenza vaccine influenza vaccinations as well. ref name cdc bulletin cite web url http www.cdc.gov flu professionals bulletin 2006 07 bulletin5 11 ... more details
Octave Gengou 1875 &ndash 1957 was a Belgian bacteriologist . He researched with Jules Bordet the Bordetella Bordetella pertussis bacteria. Biography Gengou worked at the Belgium Pasteur Institute in Brussels . With Jules Bordet in 1906 he isolated Bordetella pertussis in pure culture and declared is as the cause of Pertussis whooping cough . 1912 he developed the first Pertussis whooping cough vaccine . He also worked on various important fundamental research on a now common test for diseases e.G. the Wassermann Test of August von Wassermann See also Immunology Bacteriologist External links http www.bookrags.com biography octave gengou scit 061234 Biography of Octave Gengou Persondata Metadata see Wikipedia Persondata . NAME Gengou, Octave ALTERNATIVE NAMES SHORT DESCRIPTION DATE OF BIRTH 1875 PLACE OF BIRTH DATE OF DEATH 1957 PLACE OF DEATH DEFAULTSORT Gengou, Octave Category French microbiologists Category French biologists Category 1875 births Category 1957 deaths de Octave Gengou ... more details
DTAP may refer to DPT vaccine DTaP , a vaccine for diphtheria, pertussis, and tetanus. Development, testing, acceptance and production DTAP , a software development approach Direct Transfer Application Part DTAP , a radio telecommunication protocol for GSM or CDMA dab ... more details
Extracellular adenylate cyclase is an adenylate cyclase produced by Bordetella pertussis . ref name pmid2870055 cite journal author Kessin RH, Franke J title Secreted adenylate cyclase of Bordetella pertussis calmodulin requirements and partial purification of two forms journal J. Bacteriol. volume 166 issue 1 pages 290 6 year 1986 month April pmid 2870055 pmc 214590 doi url http jb.asm.org cgi pmidlookup?view long&pmid 2870055 ref ref name pmid2877986 cite journal author Ladant D, Brezin C, Alonso JM, Crenon I, Guiso N title Bordetella pertussis adenylate cyclase. Purification, characterization, and radioimmunoassay journal J. Biol. Chem. volume 261 issue 34 pages 16264 9 year 1986 month December pmid 2877986 doi url http www.jbc.org cgi pmidlookup?view long&pmid 2877986 ref References reflist Phosphorus oxygen lyases Toxins Category EC 4.6.1 enzyme stub ... more details
cyclase toxin of Bordetella pertussis binds to target cells via the alpha M beta 2 integrin CD11b CD18 ... Ladant D, Ullmann A title Bordatella pertussis adenylate cyclase a toxin with multiple talents journal .... ref name pmid16138079 See also pertussis toxin References Reflist Category EC 4.6.1 protein stub ... more details
Pentosyltransferases are a type of glycosyltransferase that catalyze the transfer of a pentose . Examples include adenine phosphoribosyltransferase hypoxanthine guanine phosphoribosyltransferase pertussis toxin poly ADP ribose polymerase They are classified under Enzyme Commission number EC number 2.4.2. External links MeshName Pentosyltransferases Glycosyltransferases enzyme stub Category EC 2.4.2 ... more details
E title The O Antigen Enables Bordetella parapertussis To Avoid Bordetella pertussis Induced Immunity ... humans and is responsible for a minority of cases of the disease pertussis also known as whooping cough . ref name Cherry 1996 cite journal author Cherry J title Historical review of pertussis and the classical ... more details
vaccine class1 Vaccine component2 Pertussis vaccine class2 Vaccine component3 Tetanus vaccine class3 ... diphtheria , pertussis whooping cough and tetanus . The vaccine components include diphtheria and tetanus toxoids, and killed whole cells of the organism that causes pertussis wP . DTaP and Tdap refer to similar combination vaccines in which the pertussis component is acellular . Also available is the DT or TD vaccine , which lacks the pertussis component. In the Netherlands , the acronym DTP refers to a combination vaccine against diphtheria, tetanus, and poliomyelitis . There, pertussis is known as kinkhoest and DKTP refers to a combination vaccine against diphtheria, pertussis kinkhoest, tetanus .... Combination vaccines with whole cell pertussis While pertussis had been eradicated ... seven days following vaccination with whole cell pertussis vaccine, the evidence was compatible ... healthy children. Since 2002, whole cell pertussis vaccines are no longer used in the US. Citation ... crying. Citation needed date May 2011 Combination vaccines with acellular pertussis DTaP DTaP also DTPa and TDaP is a combined vaccine against diphtheria, tetanus, and pertussis, in which the pertussis ... vaccine uses selected antigens of the pertussis pathogen to induce immunity. Because it uses .... DTaP was developed in Japan in 1981. Tdap pertussis toxoid? Tdap , sometimes known as dTap , ref ...&id 117&pid 24 ref is the acronym for the collective vaccines preventing tetanus , diphtheria , and pertussis ... by the lower case d and p , the concentration of diphtheria and pertussis toxoids has been reduced ... indicates that the pertussis toxoids are acellular . Two Tdap vaccines are available in the U.S. ... Toxoid and Acellular Pertussis Tdap Vaccine from the Advisory Committee on Immunization Practices ... Broder KR, Cortese MM, Iskander JK, et al. title Preventing tetanus, diphtheria, and pertussis among adolescents use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccines recommendations ... more details
holmesii B. holmesii br Bordetella parapertussis B. parapertussis br Bordetella pertussis B. pertussis ... to culture. Three species are human pathogen s Bordetella pertussis B. pertussis , Bordetella parapertussis ... edition 4th publisher McGraw Hill year 2004 isbn 0838585299 ref B. pertussis and occasionally B. parapertussis cause pertussis or whooping cough in humans, and some B. parapertussis strains .... pertussis and B. parapertussis , and the pathogenesis of respiratory disease caused by these bacteria has been reviewed. ref name Hewlett 1997 cite journal author Hewlett E title Pertussis current ... of Respiratory Infections Due to Bordetella pertussis and Other Bordetella Subspecies journal Clin ... filamentous haemaglutinin , pertactin , fimbriae , and pertussis toxin though expression of pertussis toxin is unique to B. pertussis . As well as assisting in adherence to epithelial cells, some of these are also ... of target cells by Bordetella pertussis journal Mol. Microbiol. volume 53 issue 6 pages 1709 19 year ... pertussis more than just making cyclic AMP journal Mol. Microbiol. volume 59 issue 2 pages 447 59 ... is present in B. pertussis , B. parapertussis and B. bronchiseptica and is responsible for phase ... pertussis BvgAS signal transduction cascade journal Proc Natl Acad Sci USA volume 91 issue ... activation of virulence regulated genes in Bordetella pertussis journal EMBO J volume ... pertussis journal J Bacteriol volume 177 issue 10 pages 2727 36 year 1995 pmid 7751282 pmc 176943 ... regulation of the vir repressed genes vrg genes in Bordetella pertussis journal J Bacteriol volume ... more details
are more likely to be infected by B. pertussis or Bordetella parapertussis B. parapertussis . B. bronchiseptica does not express pertussis toxin , which is one of the characteristic virulence factors of B. pertussis . But it has the genes to do so, highlighting the close evolutionary relationship between ... LM, Brinig MM, Relman DA, Mooi FR title Bordetella pertussis , the Causative Agent of Whooping ... Projects B pertussis Genetic sequences of the Bordetella bronchiseptica complex Sanger ... more details
The abbreviation DPT can refer to The Democratic Party of Turkmenistan The DPT vaccine Diphtheria Pertussis Tetanus vaccine The Democratic peace theory Democratic Peace Theory Dioptre , most commonly a unit measuring refraction in a lens or curved mirror Dipropyltryptamine , a psychedelic tryptamine Doctor of Physical Therapy degree Double permutation test , in statistics Pok mon Diamond and Pearl Pok mon Diamond, Pearl and Pok mon Platinum Platinum DPt , a trilogy of video game s for the Nintendo DS Dirty Pretty Things band , a band founded in 2005 Dirty Pretty Things film , a movie released in 2002 Dynamic Packet Transport Dynamic Preemption Threshold scheduling algorithm Dublin Port Tunnel Dual Port Transceiver , a computer networking device Dumbarton People s Theatre disambig de DPT fa DPT it DPT ja DPT ... more details
ptx may refer to tt Ptx Unix ptx tt , a Unix command line utility producing a permuted index Pertussis toxin , an inhibitor of G protein coupled receptors Picrotoxin , a poisonous crystalline plant alkaloid Pneumothorax , a medical condition Parallel Thread Execution , an intermediary assembler language between high level code and that which is sent to the GPU in Nvidia s CUDA programming model Plano, Texas , a city located within the metropolitan area commonly referred to as the Dallas Fort Worth metroplex . disambig de PTX it PTX pl PTX sr PTX ... more details
Orphan date January 2011 The filamentous h magglutinin adhesin FHA is a large, filamentous protein that serves as a dominant attachment factor for adherence to host Coal mining colliery epithelia Cell biology cells of the respiratory tract . It is associated with biofilm formation and possesses at least four binding domains which can bind to different Receptor biochemistry cell receptors on the Epithelium epithelial cell surface . One notable bacterium that possess filamentous h magglutinin adhesin is Bordetella pertussis , which uses this protein as a virulence factor . Category Biological matter Category Cell biology Category Coal mining Category Membrane biology Category Microbiology Category Microbiology terms Category Molecular biology Category Respiratory system Category Routes of administration Category Proteins protein stub ... more details
Universal Immunization Programme is a vaccination program launched by the Government of India in 1985. The program consists of vaccination for six diseases tuberculosis , diphtheria , pertussis whooping cough , tetanus , poliomyelitis , and measles . ref cite web title India Universal Immunization Programme Review url http whoindia.org LinkFiles Routine Immunization Acknowledgements contents.pdf publisher World Health Organisation accessdate 1 February 2012 page 3 ref ref cite web last Patra first Nilanjan title UNIVERSAL IMMUNIZATION PROGRAMME IN INDIA THE DETERMINANTS OF CHILDHOOD IMMUNIZATION url http www.isical.ac.in wemp Papers PaperNilanjanPatra.pdf publisher Indian Statistical Institute, Calcutta accessdate 1 February 2012 page 1 format PDF ref References reflist Category Vaccination ... more details
diphtheria , tetanus and pertussis ref name vaccineplace DAPTACEL DTaP diphtheria, tetanus and pertussis ref name vaccineplace Diphtheria and Tetanus Toxoids Adsorbed USP , diphtheria, tetanus and pertussis ref name vaccineplace Tetanus Toxoid Adsorbed diphtheria, tetanus and pertussis ref name vaccineplace TriHIBit DTaP Hib Booster Use diphtheria, tetanus and pertussis and haemophilus influenzae type b ref name vaccineplace Tripedia DTaP vaccine diphtheria, tetanus, pertussis ref name vaccineplace ... more details
A heterologous vaccine is a type of live vaccine where one virus is introduced to provide protection against another virus. An example is the administration of vaccinia to provide protection against variola . Like all live vaccines, it has the advantage that it replicates in the body, and therefore reduces the need for booster shots. It has the disadvantage that a potential pathogen is introduced into the body. It can be combined with the attenuation strategy in vaccine design. ref name pmid17954727 cite journal author Ho SY, Chua SQ, Foo DG, et al. title Highly attenuated Bordetella pertussis strain BPZE1 as a potential live vehicle for delivery of heterologous vaccine candidates journal Infect. Immun. volume 76 issue 1 pages 111 9 year 2008 month January pmid 17954727 pmc 2223651 doi 10.1128 IAI.00795 07 url http iai.asm.org cgi pmidlookup?view long&pmid 17954727 ref References Reflist Vaccines Category Vaccination Category Virology vaccine stub ... more details
Bordet Gengou agar is a type of agar plate optimized to isolate Bordetella , containing blood, potato extract, and glycerol, with an antibiotic such as cephalexin or penicillin and sometimes nicotinamide. ref name MM cite book title Medical Microbiology, 4th edition editor Samuel Baron chapter Bordetella author Horst Finger and Carl Heinz Wirsing von Koenig publisher University of Texas Medical Branch at Galveston date 1996 isbn 0 9631172 1 1 http www.ncbi.nlm.nih.gov bookshelf br.fcgi?book mmed&part A1712 ref The potato extract provided nitrogen and vitamins, and potato starch absorbed fatty acids present in nasal secretions or collection swab cotton that inhibited growth glycerol was a carbon source. ref name BD http www.bd.com europe regulatory Assets IFU HB CE PA PA 254400.pdf BD Bordet Gengou Agar with 15 Sheep Blood product insert also describing Bordetella Agar with Charcoal ref Medical Microbiology, 4th edition ref name MM states that Regan Lowe medium ref name BD containing charcoal, blood, and antibiotic has replaced Bordet Gengou medium as the medium of choice for routine Bordetella pertussis incubation. Bordetella bacteria were difficult to culture Jules Bordet and Octave Gengou invented the first version to isolate the bacillus, named Bordet Gengou in 1906, they believed was associated with whooping cough. In 1909, it was not yet established that the bacillus was solely the cause. ref cite journal title The Journal of Experimental Medicine author Martha Wollstein date January 9, 1909 unused data DUPLICATE DATA title THE BORDET GENGOU BACILLUS OF PERTUSSIS http jem.rupress.org content 11 1 41.abstract ref References ref name pmid2906642 cite journal author Kurzynski TA, Boehm DM, Rott Petri JA, Schell RF, Allison PE title Comparison of modified Bordet Gengou and modified Regan Lowe media for the isolation of Bordetella pertussis and Bordetella parapertussis journal J. Clin. Microbiol. volume 26 issue 12 pages 2661 3 year 1988 month December pmid 2906642 ... more details
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