disputed date March 2011 A phenome is the set of all phenotype s expressed by a cell biology cell , biological tissue tissue , organ anatomy organ , organism , or species . Just as the genome and proteome signify all of an organism s genes and proteins, the phenome represents the sum total of its phenotypic traits. Examples of human phenotypic traits are skin color , eye color , body height , or specific Personality type personality characteristics. Although any phenotype of any organism has a basis in its genotype, phenotypic expression may be influenced by environmental influences, mutation, and genetic variation such as single nucleotide polymorphism s SNPs , or a combination of these factors. Phenomics is the study of the phenome and how it is determined, particularly when studied in relation to the set of all genes genomics or all proteins proteomics . Origin and usage The term was first used by Davis in 1949, We here propose the name phenome for the sum total of extragenic, non autoreproductive portions of the cell, whether cytoplasmic or nuclear. The phenome would be the material basis of the phenotype, just as the genome is the material basis of the genotype. ref cite journal author Davis BD title The Isolation of Biochemically Deficient Mutants of Bacteria by Means of Penicillin journal Proceedings of the National Academy of Sciences of the United States of America volume 35 issue 1 pages 1 10 year 1949 month January pmid 16588845 pmc 1062948 doi 10.1073 pnas.35.1.1 ref Although phenome has been in use for many years, the distinction between the use of phenome and phenotype ... 9 ref Some usages of the term suggest that the phenome of a given organism is best understood as a kind ...?view long&pmid 16339373 ref Another team of researchers characterize the human phenome nowiki as nowiki ... the genome to the phenome and back linking genes with human brain function and structure using genetically ... http phenome.jax.org pub cgi phenome mpdcgi?rtn docs home Mouse Phenome Project at the Jackson Laboratory ... more details
The Mouse Phenome Database MPD is a web accessible database of strain biology strain characterization data for the laboratory mouse , to facilitate translational research for human health and disease. MPD characterizes phenotype as well as genotype , and provides tools for online analysis. Most phenotype data are in the form of strain surveys comparisons of 10 40 commonly used mouse strains and cover such areas as hematology , bone mineral density , cholesterol levels, endocrine function, and aging processes. Genotype data are primarily in the form of single nucleotide polymorphism s. Data are contributed by participating scientists or downloaded from public resources. ref Maddatu TP, Grubb SC, Bult CJ, Bogue MA. Mouse Phenome Database MPD . Nucleic Acids Res. 2012 Jan 40 Database issue D887 94. ref The MPD was begun in 2000, is funded by grants from the National Institutes of Health and other sources, and is headquartered at The Jackson Laboratory . References Reflist External links http phenome.jax.org Mouse Phenome Database Category Genetics Category Online databases Category Biological databases ... more details
The Epilepsy Phenome Genome Project EPGP is a government funded study to identify gene s that influence the development of epilepsy and genes that affect the response to treatment. The study involves 25 major epilepsy centers and more than 150 scientists and clinical staff around the United States, Australia and Argentina. The goal is to create a repository of clinical and genetic information on a select group of patients with epilepsy. The hope is that this information will reveal new insights and improve diagnosis and treatment. EPGP is funded by the National Institutes of Health via http www.ninds.nih.gov The National Institute for Neurological Disorders and Stroke NINDS . The long term goal of EPGP is to identify potential molecular targets that could be the basis of much more specific and effective treatments for patients who have epilepsy, and the prevention of epilepsy in those at risk. Background on Genes and Epilepsy Although heredity has been known since antiquity to cause epilepsy, the progress to date in identifying the genetic basis of epilepsy has been limited primarily to the discovery of single gene mutations that cause epilepsy in relatively rare families. For the more common types of epilepsy, heredity plays a subtler role, and it is thought that a combination of mutations in multiple genes likely determine an individual s susceptibility to seizures, as well as the responsiveness to antiepileptic medications. EPGP Phenotyping The approach to teasing apart the more complicated genetic factors in epilepsy requires a very large number of patients whose epilepsy has been extremely well characterized. EPGP investigators will be enrolling 3,750 patients and 3,000 controls over the course of the study. Details about seizure types, EEGs, imaging studies, and effects of treatment will be collected and archived in a central data repository, and all participants .... Neurology. 2006 Jun 13 66 11 1648 53. Freimer N, Sabatti C. The human phenome project ... more details
about the biological concept the abstract category in linguistics Morphome linguistics no footnotes date February 2008 Morphome is one of the omes in biology to map and classify all the morphology biology morphological features of species . Morphome is different from phenome in that it is the totality of morphological variants while phenome includes non morphological variants. See also Genome Proteome Interactome External links Empty section date January 2012 References Characterization of the Drosophila segment determination morphome. Surkova S, Kosman D, Kozlov K, Manu, Myasnikova E, Samsonova AA, Spirov A, Vanario Alonso CE, Samsonova M, Reinitz J. Dev Biol. 2007 Nov 4. Automative morphome analysis of medical biological images. Pishak, Vasyl P. Tymochko, K. B. Antoniuk, O. P. Proc. SPIE Vol. 4607, p. 411 413, Selected Papers from Fifth International Conference on Correlation Optics, Oleg V. Angelsky Ed. Strategies for the physiome project. Bassingthwaighte JB. Ann Biomed Eng. 2000 Aug 28 8 1043 58. Review. Computerized Image Analysis of Clustered Microcalcifications on Mammography Morphome tric Comparison between Mammography and Pathology. Matsunaga T, Nakamura Y, Umezu K, Fujii M, Kusama M, Koyanagi Y. Breast Cancer. 1996 Dec 20 3 3 181 190. Category Comparative anatomy biology stub ... more details
Orphan date January 2011 infobox biodatabase title ArtadeDB logo File Database.png description ARabidopsis Tiling Array based Detection of Exons scope organism Arabidopsis Thaliana center laboratory Phenome Informatics Team, Functional Genomics Research Group, Genomic Sciences Center, Japan. author Tetsuro Toyoda pmid Toyoda & al. 2005 ref name pmid16098113 released standard format url http omicspace.riken.jp ARTADE download webservice sql sparql webapp standalone license versioning frequency curation bookmark version ARTADE ARabidopsis Tiling Array based Detection of Exons is a database for the annotation of genome wide DNA microarray tiling array data in Arabidopsis thaliana Arabidopsis ref name pmid16098113 cite journal quotes yes last Toyoda first Tetsuro authorlink coauthors Shinozaki Kazuo year 2005 month Aug title Tiling array driven elucidation of transcriptional structures based on maximum likelihood and Markov models journal Plant J. volume 43 issue 4 pages 611 21 publisher location England issn 0960 7412 pmid 16098113 doi 10.1111 j.1365 313X.2005.02470.x bibcode oclc id url language eng format accessdate laysummary laysource laydate quote ref See also DNA microarray References references External links http omicspace.riken.jp ARTADE Category Biological databases Category Gene expression Category Microarrays Biodatabase stub ... more details
2011. ref Real World Uses Ploticus can be used to provide real world graphing usage such as Animal Phenome Graphing ref name Phenome http phenome.jax.org db qp?rtn snps distplot&plotstrain1 7&plotstrain2 8&rangechr 2&fromloc 124&toloc 125&plexamp 1 Mouse Phenome Database Accessed 9 September 2011. ref ... more details
disputed date March 2011 Phenomics is an area of biology concerned with the measurement of phenome s &mdash the physical and biochemical traits of organisms &mdash as they change in response to genetic mutation and environmental influences. It is used in functional genomics , pharmaceutical research and metabolic engineering . An important field of research today is trying to improve, both qualitatively and quantitatively, the capacity to measure phenomes. This include developing high throughput measurement systems. For example, the Australian Plant Phenomics Facility, an initiative of the Australian government, has developed a number of new instruments for comprehensive and fast measurements of phenotypes in both the lab and the field. RNA interference may be used to generate large numbers of random mutations in organisms such as nematode worm s. The resulting phenotype s of the creatures are then analysed. The large volumes of data generated by such work may be stored in specialised databases. ref citation url http books.google.com books?id 2LWNGRnsi8MC&pg PA166 title Applied bioinformatics author Paul M. Selzer, Richard J. Marh fer, Andreas Rohwer chapter Systems Biology The Functional Analysis of Genomes ref Selected publications Highly cited publications concerning phenomics ref According to a Google scholar search performed 2010 05 01. ref include citation last1 Schilling first1 C.H. last2 Edwards first2 J.S. last3 Palsson first3 B.O. doi 10.1021 bp9900357 issue 3 journal Biotechnology Progress pages 288 295 title Toward metabolic phenomics analysis of genomic data using flux balances volume 15 year 1999 citation last Gerlai first R. authorlink Robert Gerlai doi 10.1016 S0166 2236 02 02250 6 issue 10 journal Trends in Neurosciences pages 506 509 title Phenomics fiction or the future? volume 25 year 2002 citation last1 Freimer first1 N. last2 Sabatti first2 C. doi ... The human phenome project volume 34 year 2003 citation last1 Warringer first1 J. last2 Ericson first2 ... more details
ref Phenome and phenomics Although a phenotype is the ensemble of observable characteristics displayed by an organism, the word phenome is sometimes used to refer to a collection of traits, while the simultaneous ... 55 63 ref ref Cite journal first1 A last1 Varki year 1998 title Great Ape Phenome Project? url journal ... phenome Mouse Phenome Database http www.human phenotype ontology.org Human Phenotype Ontology http ... more details
by a particular organism, and Phenome refers to the entire set of Phenes that exist within an organism ... building blocks of a phenome are. Since the term phenotype has been used to describe traits .... Phene has emerged as a candidate building block for the phenome. Phene gene distinction Genes ... more details
to organize the Epilepsy Phenome Genome Project . ref http www.med.nyu.edu cec research genome.html NYU Phenome Genome Project ref Dr Kuzniecky described the Kuzniecky Syndrome in 1991, also known as Perisylvian ... more details
sclerosis , and head trauma . Devinsky serves as the director of the Phenome Core for the Epilepsy Phenome Genome Project , funded by an NIH multi institutional grant. Devinsky and his co investigators ... more details
wiktionary MPD may refer to NOTOC Chemistry 2 Methyl 2,4 pentanediol M Phenylenediamine m Phenylenediamine Methylphenidate Electronics pulse doppler radar Medium PRF pulse repetition frequency doppler radar used e.g. in fighter and missile applications Memory Protection Devices, a company that manufacturers battery holder s Medicine Multiple personality disorder now called dissociative identity disorder , a mental condition where two or more distinct personalities are theorized to control the behaviour of a single individual Myeloproliferative disease a group of diseases of the bone marrow Locations Meatpacking District a neighborhood in New York City Oil industry Managed Pressure Drilling general term for controlling the mud circulation to optimize the bottomhole pressure. Policing Manila Police District Milwaukee Police Department , the police department in Milwaukee, Wisconsin Minneapolis Police Department , the police department in Minneapolis, Minnesota Montreal Police Department , the police department in Montreal, Canada Memphis Police Department , the police department in Memphis, Tennessee Metropolitan Police Department of the District of Columbia , the municipal police force for the city of Washington, District of Columbia Miami Police Department Metropolitan Police District , the area policed by the Metropolitan Police Service in London, United Kingdom Mumbai Police Department Politics Movement for Democracy Cape Verde a political party in Cape Verde Movimiento Popular Democr tico , a political party in Ecuador Science Magnetoplasmadynamic thruster an electric space propulsion engine. Multivariate P lya distribution a statistical distribution Mouse Phenome Database an online database of laboratory mouse characterizations Software MPD programming language Music Player Daemon a music player server. Media MPD Psycho , a manga series by Eiji Otsuka. Other uses UTA MPD a type of diesel multiple unit railcar of Northern Ireland Railways MPD, the ICAO airline de ... more details
at the root of changes in the neurodevelopment of California s children. Autism Phenome Project In 2006, the M.I.N.D. Institute launched its Autism Phenome Project, with the objective of identifying ... more details
first7 TG last8 Kassem first8 L last9 Simpson first9 SG title The bipolar disorder phenome database ... Disorder Phenome Database. It consists of 5,721 subjects 3,186 affected in 1,177 families, 197 variables ... Disorder Phenome Database must have a legitimate scientific aim and researchers need to apply for user ... more details
species. In this regard, he coined the term Phenome , in the context of recommending a Great Ape Phenome Project . ref cite web url http www.sciencemag.org cgi content full 282 5387 239d title Great Ape Phenome Project? By Varki A, Wills C, Perlmutter D, Woodruff D, Gage F, Moore J, Semendeferi K ... more details
1 Mijak speech Standard Macedonian English Notes amija d amija mosque reduced use of the phenome d ... tu da tu a tugja foreign use of the phenome or d in place of the standard Macedonian gj trebuvad ... more details
V. coauthors Wolf, Yuri I. title Constraints and plasticity in genome and molecular phenome evolution ... in genome and molecular phenome evolution journal Nature Reviews Genetics date NaN undefined ... more details
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