chembox verifiedrevid 464215233 ImageFile Ref chemboximage correct ?? ImageFile Proflavine structure.png ImageSize IUPACName acridine 3,6 diamine OtherNames Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 6832 UNII Ref fdacite correct FDA UNII CY3RNB3K4T KEGG Ref keggcite correct kegg KEGG C11181 InChI 1 C13H11N3 c14 10 3 1 8 5 9 2 4 11 15 7 13 9 16 12 8 6 10 h1 7H,14 15H2 InChIKey WDVSHHCDHLJJJR UHFFFAOYAC ChEMBL Ref ebicite correct EBI ChEMBL 55400 StdInChI Ref stdinchicite correct chemspider StdInChI 1S C13H11N3 c14 10 3 1 8 5 9 2 4 11 15 7 13 9 16 12 8 6 10 h1 7H,14 15H2 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey WDVSHHCDHLJJJR UHFFFAOYSA N CASNo 92 62 6 CASNo Ref cascite correct CAS PubChem 7099 DrugBank Ref drugbankcite correct drugbank DrugBank DB01123 ChEBI Ref ebicite correct EBI ChEBI 8452 SMILES n1c3c cc2c1cc N cc2 ccc c3 N Section2 Chembox Properties C 13 H 11 N 3 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Proflavine pron. pro fla vin , also called proflavin and diaminoacridine , is an acriflavine derivative, a disinfectant bacteriostatic against many gram positive bacteria . It has been used in the form of the dihydrochloride and hemisulfate salts as a topical antiseptic , and was formerly used as a urinary antiseptic. Proflavine is also known to have a mutagenesis mutagenic effect on DNA by intercalation chemistry intercalating between nucleic acid base pair s. It differs from most other mutagenesis mutagenic components by causing basepair deletions or basepair insertions and not substitutions. Proflavine absorbs strongly in the blue region at 445 nm in water at pH 7 with molar extinction coefficient of c. 40,000 ref name sarre cite arxiv eprint astro ph 0608113 title The Diffuse Interstellar Bands A Major Problem in Astronomical Spectroscopy first Peter J. last Sarre year 2006 ref References reflist Category Antiseptics Category ... more details
Drugbox verifiedrevid 447905852 Combo data type combo component1 Acriflavinium chloride class1 antiseptic component2 Proflavine class2 antiseptic Clinical data tradename pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled legal CA OTC, Rx only, Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD Benz POM, CD Anab POM or CD Inv POM legal US OTC Rx only Schedule I, II, III, IV, V legal status routes of administration topical Identifiers CAS number 68518 47 8 ATCvet ATC prefix D08 ATC suffix AA03 PubChem 452192 DrugBank Ref drugbankcite correct drugbank DrugBank UNII Ref fdacite correct FDA UNII 1TW3Q60E36 Chemical data Euflavine is an antiseptic and disinfectant . Antiseptics and disinfectants Category Acridines Category Aromatic amines Category Quaternary ammonium compounds dermatologic drug stub ... more details
solution unwinds DNA by about 26 , whereas proflavine unwinds it by about 17 . This unwinding causes ... sub , acridine s such as proflavine or quinacrine , or ethidium bromide. Intercalation as a mechanism ..., 3, 18 30. ref ref Luzzati V., Masson F., Lerman L. S. Interaction of DNA and proflavine a small ... more details
Leonard Lerman is an American scientist most noted for his work on DNA. As a graduate student with Linus Pauling at the California Institute of Technology , Lerman discovered that antibodies have two binding sites. Later, perhaps his most important discovery was that certain molecules bind to DNA by Intercalation chemistry intercalation . ref Lerman L. S. Structural considerations in the interactions of deoxyribonucleic acid and acridines Journal of Molecular Biolology 1961, 3, 18 30. ref ref Luzzati V., Masson F., Lerman L. S. Interaction of DNA and proflavine a small angle x ray scattering study J. Mol. Biol. 1961, 3, 634 639. ref ref Lerman L. S. The structure of the DNA acridine complex Proc. Natl. Acad. Sci. USA, 1963, 49, 94 102. ref This discovery has shaped much of science s understanding about how drugs and mutagen s interact with DNA. Lerman led a productive research program at Vanderbilt University in Nashville, Tennessee Nashville , the University of Colorado Health Sciences Center in Denver and SUNY Albany , the State University of New York at Albany. Lerman s lab crew included at least one Nobel prize winner, Sidney Altman , and another, Tom Maniatis , who also became one of the leading molecular biologists of his time. Lerman s last major effort, begun with Stuart Fischer at State University of New York SUNY , was the invention of Temperature gradient gel electrophoresis Denaturing gradient gel electrophoresis denaturing gradient gel electrophoresis DGGE , ref Fischer S. G. and Lerman L. S. Length independent separation of DNA restriction fragments in two dimensional gel electrophoresis Cell, 1979, Jan 16 1 , 191 200. ref ref Fischer S. G. and Lerman L. S. Separation of random fragments of DNA according to properties of their sequences Proc. Natl. Acad. Sci. USA, 1980, 77, 4420 4424. ref ref Fischer S. G. and Lerman L. S. DNA fragments differing by single base pair substitutions are separated in denaturing gradient gels Correspondence with melting the ... more details
List of drugs P Pro Prz pro Propantheline bromide Pro Banthine proa prob proadifen International Nonproprietary Name INN Proamatine Probalan Probampacin probarbital sodium International Nonproprietary Name INN Proben C probenecid International Nonproprietary Name INN probucol International Nonproprietary Name INN proc prod procainamide International Nonproprietary Name INN procaine International Nonproprietary Name INN Procalamine Procan Procanbid Procapan procarbazine International Nonproprietary Name INN Procardia procaterol International Nonproprietary Name INN prochlorperazine International Nonproprietary Name INN procinolol International Nonproprietary Name INN procinonide International Nonproprietary Name INN proclonol International Nonproprietary Name INN procodazole International Nonproprietary Name INN Proctocort Proctofoam HC procyclidine International Nonproprietary Name INN procymate International Nonproprietary Name INN prodeconium bromide International Nonproprietary Name INN prodilidine International Nonproprietary Name INN prodipine International Nonproprietary Name INN prodolic acid International Nonproprietary Name INN prof prok profadol International Nonproprietary Name INN Profen Profenal profenamine International Nonproprietary Name INN Proferdex profexalone International Nonproprietary Name INN proflavine International Nonproprietary Name INN proflazepam International Nonproprietary Name INN Profloxin Hexal Australia & 91 Australia Au & 93 . Redirects to ciprofloxacin . progabide International Nonproprietary Name INN Progestasert progesterone International Nonproprietary Name INN proglumetacin International Nonproprietary Name INN proglumide International Nonproprietary Name INN Proglycem Prograf proguanil International Nonproprietary Name INN Prohance proheptazine International Nonproprietary Name INN Proketazine Prokine Immunex Corp Proklar prol pron Proleukin Chiron proligestone International Nonproprietary Name INN proline International Non ... more details
chembox verifiedrevid 443367785 ImageFile Acridine chemical structure.png ImageSize 250px IUPACName Acridine OtherNames Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 8860 InChI 1 C13H9N c1 3 7 12 10 5 1 9 11 6 2 4 8 13 11 14 12 h1 9H InChIKey DZBUGLKDJFMEHC UHFFFAOYAF SMILES1 c1ccc2c c1 cc3ccccc3n2 ChEMBL Ref ebicite correct EBI ChEMBL 39677 StdInChI Ref stdinchicite correct chemspider StdInChI 1S C13H9N c1 3 7 12 10 5 1 9 11 6 2 4 8 13 11 14 12 h1 9H StdInChIKey Ref stdinchicite correct chemspider StdInChIKey DZBUGLKDJFMEHC UHFFFAOYSA N CASNo Ref cascite correct CAS CASNo 260 94 6 PubChem 9215 ChEBI Ref ebicite correct EBI ChEBI 36420 SMILES n1c3c cc2c1cccc2 cccc3 Section2 Chembox Properties C 13 H 9 N 1 Appearance Density MeltingPt 107 C BoilingPt 346 C pKa 5.60 ref Brown, H.C., et al., in Baude, E.A. and Nachod, F.C., Determination of Organic Structures by Physical Methods , Academic Press, New York, 1955. ref Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Acridine , C sub 13 sub H sub 9 sub N, is an organic compound and a heterocyclic compound nitrogen heterocycle . Acridine is also used to describe compounds containing the C sub 13 sub N tricycle. Acridine is structurally related to anthracene with one of the central CH groups is replaced by nitrogen. Acridine, a colorless solid, was first isolated from coal tar . It is a raw material used for the production of dye s and some valuable drugs. Many acridines, such as proflavine , also have antiseptic properties. Acridine and related derivatives bind to DNA and RNA due to their abilities to Intercalation chemistry intercalate . Acridine orange 3,6 dimethylaminoacridine is a nucleic acid selective metachromatic Staining biology stain useful for cell cycle determination. Acridarsine is formally derived from acridine by replacing the nitrogen atom with one of arsenic , and acridophosphine by replacing it with one of phosphorus . History Acridine was ... more details
Unreferenced date December 2009 Orphan date December 2009 C sub 13 sub class wikitable Chemical formula Synonyms CAS number C sub 13 sub H sub 5 sub Cl sub 5 sub O sub 3 sub pentachlorophenyl salicylate 36994 69 1 C sub 13 sub H sub 7 sub MoNO sub 5 sub isocyanotoluenemolybdenum pentacarbonyl 109316 13 4 C sub 13 sub H sub 8 sub Br sub 3 sub NO sub 2 sub tribromsalan 87 10 5 C sub 13 sub H sub 8 sub F sub 2 sub O sub 3 sub diflusinal 22494 42 4 C sub 13 sub H sub 8 sub N sub 2 sub O sub 3 sub S nitroscanate 19881 18 6 C sub 13 sub H sub 8 sub OS thioxanthone 492 22 8 C sub 13 sub H sub 8 sub O sub 2 sub xanthone 90 47 1 C sub 13 sub H sub 9 sub fluorenyl radical 2299 68 5 C sub 13 sub H sub 9 sub Cl sub 2 sub NO sub 4 sub chlomethoxyfen 32861 85 1 C sub 13 sub H sub 9 sub F sub 3 sub N sub 2 sub O sub 2 sub niflumic acid 4394 00 7 C sub 13 sub H sub 9 sub N acridine 260 94 6 C sub 13 sub H sub 9 sub N phenanthridine 229 87 8 C sub 13 sub H sub 9 sub NO fluorenone oxime 2157 52 0 C sub 13 sub H sub 9 sub P acridophosphine 398 14 1 C sub 13 sub H sub 10 sub fluorene 86 73 7 C sub 13 sub H sub 10 sub ClNO diphenylcarbamoyl chloride 83 01 2 C sub 13 sub H sub 10 sub HgO sub 3 sub phenylmercuric salicylate 28086 13 7 C sub 13 sub H sub 10 sub N sub 2 sub O sub 2 sub S thiantoin 7772 37 4 C sub 13 sub H sub 10 sub O 13co 32488 48 5 C sub 13 sub H sub 10 sub O benzophenone 119 61 9 C sub 13 sub H sub 10 sub O xanthene 92 83 1 C sub 13 sub H sub 10 sub O sub 2 sub furfural acetophenone 717 21 5 C sub 13 sub H sub 10 sub O sub 3 sub diphenyl carbonate 102 09 0 C sub 13 sub H sub 10 sub O sub 5 sub isopimpinellin 482 27 9 C sub 13 sub H sub 10 sub S methyldibenzothiophene 30995 64 3 C sub 13 sub H sub 10 sub S thioxanthene 261 31 4 C sub 13 sub H sub 11 sub diphenylmethyl radical 4471 17 4 C sub 13 sub H sub 11 sub F fluorodiphenylmethane 579 55 5 C sub 13 sub H sub 11 sub NO acridine monohydrate 500013 99 0 C sub 13 sub H sub 11 sub N sub 3 sub proflavine 92 62 6 C sub 13 su ... more details
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