PBB geneid 5241 The progesteronereceptor PR also known as NR3C3 nuclear receptor subfamily 3, group C, member 3 , is an intracellular steroid receptor that specifically binds progesterone . In humans ... F, Milgrom E title Complete amino acid sequence of the human progesteronereceptor deduced from cloned ... BW title The progesteronereceptor gene maps to human chromosome band 11q13, the site of the mammary ... 4795 3 oclc doi ref Background Pfam box Symbol Progest rcpt N Name Progesteronereceptor, N terminal ... with other steroid receptors, the progesteronereceptor has a N terminus N terminal regulatory domain ... transcription activation function TAF , called TAF 3, is present in the progesteronereceptor ... A. Isoforms As demonstrated in progesteronereceptor deficient mice, the physiological effects of progesterone depend completely on the presence of the human progesteronereceptor hPR , a member ... human progesteronereceptor forms A and B journal EMBO J. volume 9 issue 5 pages 1603 14 year ... L, Sluss PM, Cramer DW title Genetic variation in the progesteronereceptor gene and ovarian ... M, Colditz GA, Hunter DJ title A functional polymorphism in the promoter of the progesteronereceptor ... ref Several studies have now shown no association between progesteronereceptor gene 331G A polymorphisms ... C, Jacobs EJ, Diver WR, Thun MJ, Calle EE title No association between the progesteronereceptor .... Progesterone antagonists prevent the structural reconfiguration. After progesterone binds to the receptor ... by ribosome s to produce specific proteins. Antagonists Progesteronereceptor antagonists work as antiprogestin s. The main example is mifepristone . Selective progesteronereceptor modulator s may also have more or less antagonist activity. Interactions Progesteronereceptor has been shown ... factor 9 basic transcription element binding protein with progesteronereceptor isoforms A and B determine ... of the two isoforms of the human progesteronereceptor are due to differential cofactor binding ... more details
A selective progesteronereceptor modulator SPRM is an agent that acts on the progesteroneprogesteronereceptorreceptor . A characteristic that distinguishes such substances from receptor full agonists such as progesterone and full antagonists such as mifepristone is that their action differs in different tissues agonist in some while antagonist in others . This mixed agonist agonist profile of action leads to selective stimulation or inhibition progesterone like action in different tissues and furthermore raises the possibility of dissociation of desirable therapeutic effects from undesirable side effects in synthetic progesteronereceptor drug candidates. ref name Chwalisz 2005 cite journal author Chwalisz K, Perez MC, Demanno D, Winkel C, Schubert G, Elger W title Selective progesteronereceptor modulator development and use in the treatment of leiomyomata and endometriosis journal Endocr ... cite journal author Ohara N title Action of progesteronereceptor modulators on uterine leiomyomas ... ref name pmid19602929 cite journal author Spitz IM title Clinical utility of progesteronereceptor .... When SPRMs bind to the progesteronereceptor, the equilibrium between the two conformational states ... structure from the endogenous hormone progesterone , but nevertheless bind to the same progesteronereceptor . In humans, there is only one gene gene PGR that codes for the receptor, but two splice variants ... selectivity of SPRMs is what conformational preference these ligands induce in the receptor. The ligand binding domain of the receptor is in equilibrium between two different conformations. The first ... regulation of gene expression. Full agonists such as progesterone which display agonist properties ... receptor modulators journal Endocr Rev volume 25 issue 1 pages 45 71 year 2004 doi 10.1210 er.2003 ... receptor modulator Selective androgen receptor modulator Selective estrogen receptor modulator Selective glucocorticoid receptor agonist Sex hormones Category hormonal agents Category Receptor modulators ... more details
its primary action through the intracellular progesteronereceptor although a distinct, membrane bound progesteronereceptor has also been postulated. ref name pmid9506743 cite journal author Luconi ... non genomic membrane progesteronereceptor in boar spermatozoa journal J. Endocrinol. volume ... different human progesteronereceptor forms A and B journal EMBO J. volume 9 issue 5 pages 1603 ... receptor by the previously elevated level of progesterone. ref name pmid13263410 cite journal doi 10.1210 ... and mucus regulated. Progesteronereceptor s are widely present in Mucous membrane submucosal .... location New Delhi isbn 81 317 0031 3 page 432 url accessdate 2010 04 15 UTC ref Progesteronereceptor antagonist s, or selective progesteronereceptor modulator s SPRM s, such as RU 486 Mifepristone ... for progesterone to have a regulatory effect, the presence of progesteronereceptor biochemistry ... IUPAC name Pregn 4 ene 3,20 dione image Progesteron.svg width 200 low res image image2 Progesterone 3D vdW.png Clinical data tradename Crinone, Endometrin Drugs.com drugs.com monograph progesterone ... 4 pregnene 3,20 dione melting point 126 specific rotation sub D sub Progesterone also known as P4 ... supports gestation and embryogenesis of humans and other species. Progesterone belongs to a class of hormones called progestogens , and is the major naturally occurring human progestogen. Progesterone ... amounts of a steroid called diosgenin , which can be converted into progesterone in the laboratory. Chemistry Progesterone was independently discovered by four research groups. ref name pmid17747122 ... cber.19340670729 ref Willard Myron Allen co discovered progesterone with his anatomy professor George ... its melting point, molecular weight, and partial molecular structure. He also gave it the name Progesterone ... WM title Progesterone how did the name originate? journal South. Med. J. volume 63 issue 10 pages 1151 5 year 1970 pmid 4922128 doi 10.1097 00007611 197010000 00012 ref Like other steroid s, progesterone ... more details
enzyme Name progesterone 5 alpha reductase EC number 1.3.1.30 CAS number 72412 84 1 IUBMB EC number 1 3 1 30 GO code 0050213 image width caption In enzymology , a progesterone 5alpha reductase EC number 1.3.1.30 is an enzyme that catalysis catalyzes the chemical reaction 5alpha pregnan 3,20 dione NADP sup sup math rightleftharpoons math progesterone NADPH H sup sup Thus, the two substrate biochemistry substrates of this enzyme are 5alpha pregnan 3,20 dione and nicotinamide adenine dinucleotide phosphate NADP sup sup , whereas its 3 product chemistry products are progesterone , nicotinamide adenine dinucleotide phosphate NADPH , and hydrogen ion H sup sup . This enzyme belongs to the family of oxidoreductase s, specifically those acting on the CH CH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is 5alpha pregnan 3,20 dione NADP 5 oxidoreductase . Other names in common use include steroid 5 alpha reductase , and Delta4 steroid 5alpha reductase progesterone . This enzyme participates in c21 steroid hormone metabolism . References reflist 1 cite journal author Cheng YJ, Karavolas HJ date 1975 title Subcellular distribution and properties of progesterone delta4 steroid 5alpha reductase in rat medial basal hypothalamus journal J. Biol. Chem. volume 250 pages 7997&ndash 8003 pmid 240847 issue 20 cite journal author Cheng YJ, Karavolas HJ date 1975 title Properties and subcellular distribution of delta4 steroid progesterone 5alpha reductase in rat anterior pituitary journal Steroids. volume 26 pages 57&ndash 71 pmid 1166484 doi 10.1016 0039 128X 75 90006 9 issue 1 1.3 enzyme stub Category EC 1.3.1 Category NADPH dependent enzymes Category Enzymes of unknown structure it Progesterone 5alfa reduttasi ja 5 ... more details
enzyme Name progesterone 11 alpha monooxygenase EC number 1.14.99.14 CAS number 37256 77 2 IUBMB EC number 1 14 99 14 GO code 0050212 image width caption In enzymology , a progesterone 11alpha monooxygenase EC number 1.14.99.14 is an enzyme that catalysis catalyzes the chemical reaction progesterone AH sub 2 sub O sub 2 sub math rightleftharpoons math 11alpha hydroxyprogesterone A H sub 2 sub O The 3 substrate biochemistry substrates of this enzyme are progesterone , AH2, and oxygen O sub 2 sub , whereas its 3 product chemistry products are 11alpha hydroxyprogesterone , A, and water H sub 2 sub O . This enzyme belongs to the family of oxidoreductase s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is progesterone,hydrogen donor oxygen oxidoreductase 11alpha hydroxylating . This enzyme is also called progesterone 11alpha hydroxylase . This enzyme participates in c21 steroid hormone metabolism . References reflist 1 cite journal author Shibahara M, Moody JA, Smith LL date 1970 title Microbial hydroxylations. V. 11 alpha hydroxylation of progesterone by cell free preparations of Aspergillus ochraceus journal Biochim. Biophys. Acta. volume 202 pages 172&ndash 9 pmid 5417182 issue 1 1.14 enzyme stub Category EC 1.14.99 Category Enzymes of unknown structure it Progesterone 11alfa monoossigenasi ja 11 ... more details
enzyme Name progesterone monooxygenase EC number 1.14.99.4 CAS number 37256 85 2 IUBMB EC number 1 14 99 4 GO code 0050214 image width caption In enzymology , a progesterone monooxygenase EC number 1.14.99.4 is an enzyme that catalysis catalyzes the chemical reaction progesterone AH sub 2 sub O sub 2 sub math rightleftharpoons math testosterone acetate A H sub 2 sub O The 3 substrate biochemistry substrates of this enzyme are progesterone , AH sub 2 sub , and Dioxygen O sub 2 sub , whereas its 3 product chemistry products are testosterone acetate , A, and Water molecule H sub 2 sub O . This enzyme belongs to the family of oxidoreductase s, specifically those acting on paired donors, with O sub 2 sub as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O miscellaneous. Clarifyme date January 2009 The systematic name of this enzyme class is progesterone,hydrogen donor oxygen oxidoreductase hydroxylating . This enzyme is also called progesterone hydroxylase . References reflist 1 cite journal author Rahim MA and Sih CJ date 1966 title Mechanisms of steroid oxidation by microorganisms. XI. Enzymatic cleavage of the pregnane side chain journal J. Biol. Chem. volume 241 pages 3615&ndash 3623 pmid 5950688 Category EC 1.14.99 Category Enzymes of unknown structure 1.14 enzyme stub it Progesterone monoossigenasi ja ... more details
wiktionary Receptor may refer to Cellular Sensory receptor , in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse Molecular Receptor biochemistry , in biochemistry, a protein molecule that receives and responds to a neurotransmitter, or other substance Special cases of receptors in biochemistry Cell surface receptor , a receptor on the outer surface of a cell membrane, that takes part in communication between the cell and the outside world Nuclear receptor , a receptor found within cells that is responsible for sensing steroid and thyroid hormones and certain other molecules Immune receptor , a receptor that occurs on the surface of immunocytes and binds to antigens Telecommunication Receiver radio , a device for the reception of electromagnetic signals disambig ar ca Receptor fr R cepteur id Reseptor it Recettore lt Receptorius nl Receptor oc Receptor ro Receptor ru sl Receptor fi Reseptori zh ... more details
Autoimmune progesterone dermatitis may appear as urticarial papules, deep gyrate lesions, papulovesicular lesions, an eczematous eruption, or as targetoid lesions. ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. ISBN 0 7216 2921 0. ref rp 82 Autoimmune progesterone dermatitis initially manifests with eye symptoms, e.g. burning, and progresses into rashes. Its relapsing remitting pattern in women correspond to the progesterone levels durning the menstrual cycle, which spike twice a month. It is an extremely rare disease, only perhaps 50 cases have ever been reported. See also Skin lesion References reflist Cutaneous condition stub Category Eczema ar ... more details
Intravaginal progesterone devices are broadly used in the control of reproductive management in cattle. The chain mechanism of action is as follows Progesterone suppresses the release of Gonadotropin releasing hormone GnRH . Low levels of GnRH prevent the emergence of a dominant follicle by diminishing release of LH and FSH hormones. Current follicular waves cease and a new wave emerges 3 5 days after implant. A dominant follicle develops but there is no ovulation as LH release is prevented by suppression of GnRH. Removal of progesterone device produces a surge of GnRH, generating a pulse of LH that induces ovulation. Clinical uses of PRID ref Reproduction in Cattle. A.R. Peters and P.J.H. Ball ref Synchronisation of oestrus in conjunction with prostaglandin ref Deletang et al. 2006 . Efficacy of PRID with injection of PGF2a for synchronising oestrus in French dairy and beef cattle. World Biuatric Congress. ref . ref McPhee et al. 1983 . Multiple use of progesterone releasing intravaginal devices for synchronisation of oestrus and ovulation in cattle. Australian Vet Journal, 60 p40 43 ref The PGF2 injection helps to ensure there is no residual CL and the potentially ovulating follicle has been held primed for less time, enhancing its viability. Protocol PRID for 9 days. PGF2 injection on days 5 8. Serve on observed oestrus or fixed time once at 56h or twice at 48h and 72h. Induction of oestrus in anoestrus cows ref Tjondronegoro et al. 1987 . Effects of progesterone intravaginal devices on synchronisation of oestrus in post partum dairy cows. Journal of Dairy Sciences,70, p2162 2167 ref Treatment of follicular cysts Persistent ovarian follicles Improve oocyte quality Reduction of early embryonic death and improved fertility Treatment of repeat breeders Increased fertility in embryo transfer protocols References reflist Category Veterinary medicine ... more details
Multiple issues orphan March 2012 essay like February 2011 expert February 2011 Progesterone devices are broadly used in the control of reproductive management in livestock . They work by increasing circulating plasma progesterone levels with the following consequences Progesterone suppresses the secretion of gonadotropin releasing hormone GnRH from the hypothalamus . This is done via a negative feedback to the hypothalamus neuroendocrine cell s, by inhibition of KiSSpeptin KiSS1 derived peptide receptor , a protein needed for the release of GnRH. Low levels of GnRH prevent the emergence of a dominant Ovarian follicle follicle by reducing the release of Luteinizing hormone LH and Follicle stimulating hormone FSH hormones. Current follicular waves cease and a new wave emerges 3 5 days after implant. A dominant follicle develops but there is no ovulation as LH release is prevented by suppression of GnRH. Removal of progesterone device produces a surge of GnRH, generating a pulse of LH that induces ovulation. Methods of progesterone administration Progesterone Releasing Intravaginal Device PRID . For use in cattle and buffalo. They consist on a stainless spiral coil coated with an inert silicone rubber matrix impregnated in progesterone 1.55g . It has a nylon string that is placed hanging out of the vagina. Tying a loop on the string can facilitate removal of the device in the event ... silicone elastomer device impregnated in progesterone 1.38g . It has a plastic tail to ease removal. The curve of plasma progesterone in Oophorectomy ovariectomised cows fitted with either PRID ... device. It has been suggested that this increased level of plasma progesterone is due to optimal contact ... impregnated intravaginal sponge. For use mainly in sheep. Clinical uses of Progesterone devices ... . ref McPhee et al. 1983 . Multiple use of progesterone releasing intravaginal devices for synchronisation ... for less time, enhancing its viability. Protocol Progesterone for 9 days. PGF2 injection on days ... more details
macromolecular crystallography Crystallographic structure of the human progesteronereceptor ... 3, such as the androgen receptor , estrogen receptor s, glucocorticoid receptor , and progesterone ... and progesteronereceptorprogesterone receptors and therefore blocks the activity of the endogenous ... ProgesteroneReceptor Modulators selective progesteronereceptor modulator SPRM s . The mechanism of action ... progesteronereceptor PR Progesteronereceptor Gene PGR progesterone style width 250px background ... ME title Structure of the progesteronereceptor deoxyribonucleic acid complex novel interactions required ... receptor gamma PPAR green and Retinoid X receptor alpha RXR cyan bound to double stranded DNA magenta and two molecules of the Nuclear receptor coactivator 2 NCOA2 coactivator red . The PPAR ... that affects the receptor s behavior is present. More specifically, ligand binding to a nuclear receptor results in a chemical conformation conformational change in the receptor, which, in turn, activates the receptor, resulting in Regulation of gene expression Up regulation and down regulation ... them from other classes of receptor biochemistry receptors is their ability to directly ... . As discussed below, nuclear receptors may be classified according to either Nuclear receptor Mechanism of action mechanism ref name Mangelsdorf 1995 ref name Novac 2004 or Nuclear receptor Family ... Structures of selected endogenous nuclear receptor ligands and the name of the receptor that each ... receptor s, ref name pmid17132856 have no known or at least generally agreed upon endogenous ligands. Some of these receptors such as Farnesoid X receptor FXR , Liver X receptor LXR , and PPAR bind ... androstane receptor CAR and Pregnane X receptor PXR appear to function as xenobiotic ... sandwich filling . Along with the DBD, the LBD contributes to the dimerization interface of the receptor ... in sequence between various nuclear receptors. valign top Image Nuclear Receptor Structure.png thumb ... more details
A somatomedin receptor is a receptor which binds somatomedin . There are two types Insulin like growth factor 1 receptor Insulin like growth factor 2 receptor External links MeshName Somatomedin Receptor Growth factor receptors Category Receptors biochem stub ... more details
Unreferenced stub auto yes date December 2009 Sex hormone receptor s belong to the group of steroid hormone receptor s and interact with sex hormones . Three sex hormone steroid receptors can be distinguished Androgen receptor s Estrogen receptor s Progesteronereceptor s Transcription factors g2 DEFAULTSORT Sex Hormone Receptor Category Intracellular receptors Cell biology stub es Receptor de hormonas sexuales ... more details
, progesterone and DHEA have antagonist effects on the GR. Interactions Glucocorticoid receptor has ...PBB geneid 2908 The glucocorticoid receptor GR , or GCR also known as NR3C1 nuclear receptor subfamily 3, group C, member 1 is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed ... development , metabolism , and Immune system immune response . Because the receptor gene is expressed ... Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily glucocorticoid, mineralocorticoid, progesterone, and androgen receptors journal Pharmacol Revl ... 2005 month October pmid 16236742 doi 10.1056 NEJMra050541 url issn ref The unbound receptor resides in the cytosol of the cell the part of the cell outside of the cell nucleus nucleus . After the receptor is bound to glucocorticoid, the receptor glucorticoid complex can take either of two paths. The activated ... MG, Evans RM title Primary structure and expression of a functional human glucocorticoid receptor ... receptor gene is in 5q31 q32 corrected journal Genomics volume 4 issue 4 pages 610 2 year 1989 month ... doi 10.1016 S0039 128X 99 00014 8 issn ref the glucocorticoid receptor is modular in structure ref name ... receptor structure function relationship journal J. Steroid Biochem. Mol. Biol. volume 94 issue 5 ... of hormone, the glucocorticoid receptor GR resides in the cytosol complexed with a variety ... receptor GR resulting in release of the heat shock proteins. The resulting activated form ... mechanism of action involves homodimerization of the receptor, translocation via active transport ... receptor journal Proc. Natl. Acad. Sci. U.S.A. volume 91 issue 2 pages 752 6 year ..., the glucocorticoid receptor is gaining interest as a novel representative of neuroendocrine ... upon the brain. The receptor is now implicated in both short and long term adaptations seen in response ... receptor function in Major Depressive Disorder journal Prog Neurobiol volume 88 issue 1 pages 17 31 ... more details
PBB geneid 10280 The sigma 1 receptor sub 1 sub R is a Chaperone protein chaperone protein at the endoplasmatic reticulum ER that modulates calcium signaling through the IP3 receptor . ref name Hayashi cite journal author Hayashi T, Su TP year 2007 title Sigma 1 receptor chaperones at the ER mitochondrion ... pages 596 610 pmid 17981125 doi 10.1016 j.cell.2007.08.036 url ref In humans, the sigma 1 receptor is encoded ..., Leibach FH, Ganapathy V title Cloning and functional expression of the human type 1 sigma receptor ... sigma receptor gene journal J. Neurochem. volume 70 issue 2 pages 443 51 year 1998 month February pmid 9453537 doi 10.1046 j.1471 4159.1998.70020443.x url ref The sigma 1 receptor is a transmembrane ... author Zhang H, Cuevas J title sigma Receptor activation blocks potassium channels and depresses ... affinity of hundreds of synthetic compounds to the sigma 1 receptor. An endogenous ligand biochemistry ligand for the sigma 1 receptor has yet to be conclusively identified, but the trace amine and hallucinogen ... DHEA and pregnenolone , can all activate the receptor. ref name Fontanilla cite journal author Fontanilla ... Receptor Regulator journal Science volume 323 issue 5916 pages 934 937 pmid 19213917 doi 10.1126 science.1166127 ... 2947205 ref Characteristics The sigma 1 receptor is defined by its unique pharmacological profile. In 1976 ... receptors and a new type of opioid receptor was proposed. ref name pmid945347 cite journal author ... opioid receptor could not be blocked by opioid antagonists naloxone and naltrexone . Consequently, the opioid classification was eventually dropped and the receptor was later termed the sigma 1 receptor ... steroid s like progesterone . ref name pmid12871086 cite journal author Su TP, Hayashi T title Understanding ... 2073 80 year 2003 pmid 12871086 doi 10.2174 0929867033456783 ref Structure The sigma 1 receptor is an integral ... Hydropathy analysis of the sigma 1 receptor indicates three hydrophobic regions, with some evidence for two transmembrane segments. A crystal structure of the sigma 1 receptor is unavailable ... more details
ref in the cytoplasm and then translocating into the nucleus. The androgen receptor is most closely related to the progesteronereceptor , and progestin s in higher dosages can block the androgen receptor ... width caption crystal structure of the human androgen receptor ligand binding domain bound with an androgen receptor nh2 terminal peptide, ar20 30, and r1881 Pfam PF02166 Pfam clan InterPro IPR001103 SMART PROSITE MEROPS SCOP TCDB OPM family OPM protein CAZy CDD File Human androgen receptor and androgen binding.svg thumb 294 px Normal function of the androgen receptor. Testosterone T enters the cell ..., the androgen receptor AR undergoes a conformational change and releases heat shock proteins hsps ... KB, el Awady MK, Wilson EM, French FS title Androgen receptor defects historical, clinical ... LK, Trifiro MA title Molecular pathology of the androgen receptor in male in fertility journal Reprod ... repeats in the human androgen receptor a molecular basis for disease journal J. Mol. Endocrinol ... receptor in prostate and ovarian malignancies journal Front. Biosci. volume 8 issue pages d780 800 year 2003 month May pmid 12700055 doi 10.2741 1063 url ref The androgen receptor AR , also known as NR3C4 nuclear receptor subfamily 3, group C, member 4 , is a type of nuclear receptor ref name pmid17132855 ... of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily glucocorticoid, mineralocorticoid, progesterone, and androgen receptors journal Pharmacol. Rev. volume ... of the androgen receptor is as a DNA binding transcription factor that regulates gene expression ... edrv 8 1 1 ref however, the androgen receptor has other functions as well. ref name pmid12351684 cite ... receptor activation. ref name pmid16633980 cite journal author Davison SL, Bell R title ... receptor activating hormone in the Wolffian duct , whereas dihydrotestosterone is the main androgenic ... function from androgen receptor knockout models journal Hum Reprod Update volume 16 issue 5 ... more details
Intracellular receptors are receptor biochemistry receptor s located inside the cell biology cell rather than on its cell membrane . Examples are the class of nuclear receptor s located in the cell nucleus and the IP3 receptor IP sub 3 sub receptor located on the endoplasmic reticulum . The ligand s that bind to them are usually intracellular second messenger s like inositol trisphosphate IP sub 3 sub and extracellular lipophilicity lipophilic hormone s like steroid hormone s. Some intracrine peptide hormone s also have intracellular receptors. Members This list is mirrored on receptor biochemistry and nuclear receptor please update all simultaneously Transcription factors Steroid hormone receptor Sex hormone receptor s sex hormone s Estrogen receptor and Androgen receptor one type Vitamin D receptor vitamin D , one type Glucocorticoid receptor glucocorticoid s, one type Mineralocorticoid receptor mineralocorticoids , one type Thyroid hormone receptor and Retinoic acid receptor vitamin A and related compounds Peroxisome proliferator activated receptor s PPARs, , and Retinoid X receptor Farnesoid X receptor Liver X receptor Pregnane X receptor Constitutive androstane receptor Various Sigma 1 receptor Sigma sub 1 sub neuroactive steroid neurosteroids IP3 receptor IP sub 3 sub receptor inositol triphosphate , IP sub 3 sub See also Receptor biochemistry Receptor Steroid hormone External links http www.nuclear receptor.com Nuclear Receptor journal homepage http nrr.georgetown.edu NRR nrrhome.htm Nuclear receptor resource at Georgetown University http www.nursa.org Nuclear receptor signalling atlas NURSA, open access journal Transcription factors Cell signaling Category Intracellular receptors Intracellular receptors it Recettore intracellulare zh ... more details
DISPLAYTITLE D sub 2 sub like receptor The D sub 2 sub like receptors are a subfamily of dopamine receptor s that bind the endogenous neurotransmitter dopamine . The D sub 2 sub like subfamily consists of three G protein coupled receptor s which are coupled to Gi alpha subunit G sub i sub G sub o sub and mediate IPSP inhibitory neurotransmission , including D2 receptor D sub 2 sub , D3 receptor D sub 3 sub , and D4 receptor D sub 4 sub . For more information, please see the respective main articles of the individual subtypes Main D2 receptor Main D3 receptor Main D4 receptor See also D1 like receptor D sub 1 sub like receptor References Reflist 2 Unreferenced date February 2010 G protein coupled receptors Cell signaling Dopaminergics Category G protein coupled receptors Category Signal transduction Category Cell signaling transmembranereceptor stub ... more details
An immune receptor or immunologic receptor is a Receptor biochemistry receptor , usually on a cell membrane , which binds to a substance for example, a cytokine and causes a response in the immune system . Types The main receptors in the immune system are pattern recognition receptors PRRs , Toll like receptor s TLRs , killer activated receptor killer activated and killer inhibitor receptor s KARs and KIRs , complement receptor s, Fc receptors , B cell receptor s and T cell receptor s. ref name Immunology20Unless Lippincott s Illustrated Reviews Immunology. Paperback 384 pages. Publisher Lippincott Williams & Wilkins July 1, 2007 . Language English. ISBN 0781795435. ISBN 978 0781795432. Page 20 ref class wikitable Comparison Receptor Bind to ref name Immunology20Unless Function ref name Immunology20Unless align left pattern recognition receptors PRRs br e.g. Toll like receptor TLRs , NOD like receptor NLRs pathogen associated molecular pattern s PAMP Mediate cytokine production inflammation destroying pathogen killer activated receptor killer activated and killer inhibitor receptor s KARs and KIRs Avails NK cells to identify abnormal host cells KAR or inhibit inappropriate host cell destruction KIR complement receptor s complement proteins on e.g. microbes Allow phagocytic and B cells to recognize microbes and immune complexes Fc receptors epitope antibody complexes Stimulate phagocytosis B cell receptor s epitope s B cell differentiation into plasma cells and proliferation T cell receptor s linear epitopes bound to major histocompatibility complex MHC Activate T cells Cytokine receptor s cytokine s regulation and co ordination of immune responses See also antigen templates at bottom References references External links MeshName immunologic receptor Transmembrane receptors Immune receptors Category Immune system nl Immuunreceptor ar ... more details
DISPLAYTITLE 5 HT sub 1 sub receptor The 5 HT sub 1 sub receptors are a subfamily of 5 HT receptor s that bind the endogenous neurotransmitter serotonin 5 hydroxtryptamine, 5 HT . ref name pmid7938165 cite journal author Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP title International Union of Pharmacology classification of receptors for 5 hydroxytryptamine Serotonin journal Pharmacol. Rev. volume 46 issue 2 pages 157 203 year 1994 pmid 7938165 doi issn url http pharmrev.aspetjournals.org cgi content abstract 46 2 157 ref The 5 HT sub 1 sub subfamily consists of five G protein coupled receptor s GPCRs that are coupled to Gi alpha subunit G sub i sub G sub o sub and mediate IPSP inhibitory neurotransmission , including 5 HT1A receptor 5 HT sub 1A sub , 5 HT1B receptor 5 HT sub 1B sub , 5 HT1D receptor 5 HT sub 1D sub , 5 HT1E receptor 5 HT sub 1E sub , and 5 HT1F receptor 5 HT sub 1F sub . There is no 5 HT sub 1C sub receptor, as it was reclassified as the 5 HT2C receptor 5 HT sub 2C sub receptor . For more information, please see the respective main articles of the individual subtypes Main 5 HT1A receptor Main 5 HT1B receptor Main 5 HT1D receptor Main 5 HT1E receptor Main 5 HT1F receptor See also 5 HT2 receptor 5 HT sub 2 sub receptor References reflist G protein coupled receptors Cell signaling Serotonergics Category G protein coupled receptors Category Signal transduction Category Cell signaling hu 5 HT1 receptor ru 5 HT1 sr 5 HT1 receptor ... more details
Unreferenced stub auto yes date December 2009 Orphan date December 2009 The somatotropin receptor , or growth hormone receptor , is a member of the cytokine receptor superfamily. One growth hormone molecule binds to one Receptor biochemistry receptor and then recruits a second receptor to form a protein dimer dimer through which Cell signaling signalling occurs. Growth hormone has a Gaussian function bell shaped dose response curve because high concentrations actually prevent dimerization of the receptors and prevent signalling. DEFAULTSORT Somatotropin Receptor Category Transmembrane receptors Biochemistry stub ... more details
receptor s, whose members have certain conserved motifs in their extracellular amino acid domain. The IL 2 receptor belongs to this chain, whose chain common to several other cytokines deficiency is directly ... receptor s, whose members are receptors mainly for interferon s. Immunoglobulin superfamily Immunoglobulin ... body Tumor necrosis factor receptor family , whose members share a cysteine rich common ... and CD30 , besides the ligands on which the family is named TNF . Chemokine receptor s, two of which ... receptors Comparison class wikitable Type Examples Structure Mechanism type I cytokine receptor Type 1 interleukin receptors Erythropoietin receptor GM CSF receptor G CSF receptor growth hormone receptor prolactin receptor Oncostatin M receptor Leukemia inhibitory factor receptor rowspan 2 Certain ... transduction pathways type II cytokine receptor Type II interleukin receptors interferon alpha beta receptor interferon gamma receptor Many members of the immunoglobulin superfamily Interleukin 1 receptor Colony stimulating factor 1 receptor CSF1 CD117 C kit receptor Interleukin 18 receptor Share ... s, and even some cytokines. Tumor necrosis factor receptor family CD27 CD30 CD40 CD120 Lymphotoxin beta receptor cysteine rich common extracellular binding domain chemokine receptor s Interleukin 8 receptor CCR1 CXCR4 MCAF receptor NAP 2 receptor 7TM Receptor Seven transmembrane helix G protein coupled TGF beta receptors TGF beta receptor 1 TGF beta receptor 2 Solubility Cytokine receptors may ... Cytokine receptors Category Cytokine receptors membrane protein stub receptor stub cs Cytokinov receptor it Recettori accoppiati a chinasi sr Citokinski receptor sv Cytokinreceptor ... more details
DISPLAYTITLE D sub 1 sub like receptor The D sub 1 sub like receptors are a subfamily of dopamine receptor s that bind the endogenous neurotransmitter dopamine . The D sub 1 sub like subfamily consists of two G protein coupled receptor s which are coupled to G s alpha G sub s sub and mediate EPSP excitatory neurotransmission , including D1 receptor D sub 1 sub and D5 receptor D sub 5 sub . For more information, please see the respective main articles of the individual subtypes Main D1 receptor Main D5 receptor See also D2 like receptor D sub 2 sub like receptor References Reflist 2 Unreferenced date February 2010 G protein coupled receptors Cell signaling Dopaminergics Category G protein coupled receptors Category Signal transduction Category Cell signaling transmembranereceptor stub ... more details
Unreferenced date November 2006 Orphan date February 2009 A deep receptor is an element of the nervous system that is devoted to the reception of deep sensibility as opposed to tactile sensibility . A deep receptor furnishes information of what is happening in muscle , tendon s and joint s. They thus participate in proprioception . DEFAULTSORT Deep Receptor Category Nervous system Med stub ... more details
receptor in the CNS is modulated by female sex hormones estradiol and progesterone . Combination of the hormones decrease the receptor concentration in the ventral hippocampus in rats and could thus ...DISPLAYTITLE 5 HT sub 2C sub receptor PBB geneid 3358 The 5 HT sub 2C sub receptor is a subtype of 5 HT receptor that binds the endogenous neurotransmitter serotonin 5 hydroxytryptamine, 5 HT . It is a G protein coupled receptor GPCR that is coupled to Gq alpha subunit G sub q sub G sub 11 sub and mediates EPSP excitatory neurotransmission . HTR2C denotes the human gene encoding for the Receptor biochemistry receptor , ref name entrez cite web title Entrez Gene HTR2C 5 hydroxytryptamine serotonin receptor 2C url http www.ncbi.nlm.nih.gov gene 3358?ordinalpos 2&itool EntrezSystem2.PEntrez.Gene.Gene ... expression of the gene encoding the human serotonin 5 HT sub 2C sub receptor journal Eur. J. Pharmacol ... and in females one of the two copies of the gene is repressed, polymorphisms at this receptor can ... across the periphery and brain in humans. Function The 5 HT sub 2C sub receptor is one of the many binding sites for serotonin . Activation of this receptor by serotonin inhibits dopamine and norepinephrine ... editing of the human serotonin 5 HT2C receptor. alterations in suicide and implications for serotonergic ... use is limited by multiple undesirable actions on various neurotransmitter s and Receptor ... . Over a period of 1 2 weeks, the receptor begins to downregulate , along with the downregulation ... in response to agonists for the receptor, and upregulate in response to antagonists. The 5 HT sub ... via actions of receptor subtypes 5 HT sub 2A sub and 5 HT sub 2C sub . ref name pmid18208678 cite ... As such, the 5 HT sub 2C sub receptor is a significant modulator of Hypothalamic pituitary adrenal ..., Tecott LH title Serotonin activates the hypothalamic pituitary adrenal axis via serotonin 2C receptor ... and oxytocin which is partially mediated via 5 HT sub 2C sub receptor. Responses during such conditions ... more details
Encyclopedia
top
