Distinguish C peptide C reactive proteinprotein kinase C PBB geneid 5624 Protein C , also known ... connected by a disulfide bond . ref name foster rp 4673 The protein C zymogen is activated when it binds to thrombin , another protein heavily involved in coagulation, and protein C s activation ... proteinC for severe sepsis journal Cochrane database of systematic reviews Online date 2011 04 .... ref name stenflo He named it proteinC because it was the third protein peak C that elution eluted ... connected by a disulfide bond between Cys sup 183 sup and Cys sup 319 sup . File ProteinC 1D schematic.png ... name mather rp 6822 The remaining protein C zymogen comprises slightly modified forms of the protein ... C, the protein may be said to be activated not by thrombin but the thrombin thrombomodulin or even ... activation of protein C by forming an salt bridge protein and supramolecular electrostatic ... coagulation thrombin left and proteinC right pathways. In the blood coagulation pathway, thrombin ... on the cell membrane of the platelet. Thrombin also cross over into the proteinC pathway by converting proteinC into APC. APC in turn converts factor V into Vi, and VIIIa into VIIIi. Finally APC activates ... 211s Activated proteinC cleaves Plasmodium falciparum histone s which are released during infection ... of activated protein C by a new protein. A possible function for bovine protein S journal J ... Angiology Category Hematology da ProteinC de ProteinC es Prote na C fr Prot ine C hr ProteinC id ProteinC it Proteina C nl Prote ne C pl Bia ko C pt Prote na C ru C sv ProteinC ... isbn 0 7514 0499 3 oclc doi url accessdate ref rp 6822 ref name morton is a zymogen ic inactive protein ... in humans and other animals. Activated protein C APC performs these operations primarily by proteolysis ... of serine in its active site . ref name nicolaes rp 35 In humans, protein C is encoded by the PROC ... of protein C is a vitamin K dependent glycoprotein that circulates in blood Blood plasma plasma ... more details
Infobox Disease Name Activated proteinC resistance Image Caption DiseasesDB ICD10 ICD9 ICD9 289.81 ICDO OMIM 188055 MedlinePlus eMedicineSubj eMedicineTopic MeshID D020016 Activated proteinC resistance is a hemostasis hemostatic disorder characterized by a poor anticoagulant response to activated proteinC APC . This results in an increased risk of venous thrombosis , which can cause myocardial infarction heart attacks , stroke s, and other problems with circulation. ref cite journal author Dahlb ck B title The discovery of activated proteinC resistance journal J. Thromb. Haemost. volume 1 issue 1 pages 3 9 year 2003 pmid 12871530 doi 10.1046 j.1538 7836.2003.00016.x ref The disorder can be acquired or inherited, the hereditary form having an autosomal Dominance genetics dominant inheritance pattern. ref cite journal pmid 7902898 year 1993 month December author Koster T, Rosendaal FR, De Ronde H, Bri t E, Vandenbroucke JP, Bertina RM title Venous thrombosis due to poor anticoagulant response to activated proteinC Leiden Thrombophilia Study volume 342 issue 8886 8887 pages 1503 6 issn 0140 6736 journal Lancet doi 10.1016 S0140 6736 05 80081 9 ref Pathophysiology File ProteinC anticoagulant.jpg thumb ProteinC Anticoagulant Pathway Thrombin escaping from a site of vascular injury ... procoagulant properties and instead becomes a potent activator of proteinC. Activated proteinC ... clot formation to sites of vascular injury. T Thrombin, PC ProteinC, Activated ProteinC APC, PS Protein S Activated proteinC with protein S as a cofactor degrades Factor V a and Factor VIII a. Activated proteinC resistance is the inability of proteinC to cleave Factor V a and or Factor VIII a, which ... and acquired activated proteinC resistance journal Semin Vasc Med volume 3 issue 1 pages 33 46 year ... proteinC resistance. ref cite journal author Sheppard DR title Activated proteinC resistance ... Category Defects of enzyme cofactors disease stub de APC Resistenz es Resistencia a prote na C activada ... more details
Infobox Disease Name ProteinC deficiency Image Caption DiseasesDB 10807 ICD10 ICD9 ICD9 289.81 ICDO OMIM 176860 MedlinePlus eMedicineSubj med eMedicineTopic 1923 MeshID D020151 ProteinC deficiency is a rare ... C title Deficiency of proteinC in congenital thrombotic disease journal J. Clin. Invest. volume 68 ... belongs to a group of genetic disorders known as thrombophilia s. The prevalence of proteinC deficiency has been estimated to about 0.2 to 0.5 of the general population. ProteinC deficiency is associated ... 4 1 15 pmc 1592479 PMC 1592479 ref Pathophysiology The main function of proteinC is its anticoagulant ... types of proteinC mutations that lead to proteinC deficiency ref name pmid16968541 Type I Quantitative defects of proteinC low production or short protein half life Type II Qualitative defects ..., factors V VIII and others have been described. The majority of people with proteinC ... sixteen cases of homozygous proteinC deficiency had been described two abnormal copies of the gene, leading to absence of functioning proteinC in the bloodstream . This may manifest itself as purpura ... who develop a venous clot regardless of underlying cause. ref Goldenberg NA, Manco Johnson MJ. ProteinC deficiency. Haemophilia. 2008 Nov 14 6 1214 21 ref Studies have demonstrated an increased risk of recurrent venous thromboembolic events in patients with proteinC deficiency. Therefore, long ... Johnson MJ. ProteinC deficiency. Haemophilia. 2008 Nov 14 6 1214 21 ref Homozygous proteinC defect constitutes a potentially life threatening disease, and warrants the use of supplemental proteinC concentrates. fact date April 2008 Liver transplant may be considered curative for homozygous proteinC deficiency. ref Pediatr Transplant. 2009 Mar 13 2 251 4. Epub 2008 May 11. Long term survival of a child with homozygous proteinC deficiency successfully treated with living donor liver transplantation. ref References reflist Hematology Category Coagulopathies fr D ficit en prot ine C pl ... more details
Pfam box Symbol SP C Propep Name Surfactant proteinC, N terminal propeptide image 1spf opm.gif width 200 caption Pulmonary surfactant associated polypeptide SP CProtein Pfam PF08999 InterPro IPR001729 SMART Prosite PDOC00298 SCOP TCDB OPM family 75 OPM protein 1spf PDB protein Name Pulmonary surfactant associated proteinC surfactant, pulmonary associated proteinC caption image width HGNCid 10802 Symbol Pulmonary surfactant associated proteinC SFTPC AltSymbols SFTP2 EntrezGene 6440 OMIM 178620 RefSeq NM 003018 UniProt P11686 PDB ECnumber Chromosome 8 Arm p Band 21 LocusSupplementaryData Surfactant proteins C are a family of related pulmonary surfactant proteins. The propeptide of pulmonary surfactant associated proteinC human protein from this family has an N terminal alpha helical segment whose suggested function was stabilization of the protein structure, since the latter can irreversibly transform from its native alpha helical structure to beta sheet aggregates and form amyloid fibrils. The correct intracellular trafficking of proSP C has also been reported to depend on the propeptide. ref name pmid16478467 cite journal author Li J, Liepinsh E, Alml n A, Thyberg J, Curstedt T, J rnvall H, Johansson J title Structure and influence on stability and activity of the N terminal propeptide part of lung surfactant proteinC journal Febs J. volume 273 issue 5 pages 926 35 year 2006 month March pmid 16478467 doi 10.1111 j.1742 4658.2006.05124.x url ref References reflist External links MeshName Pulmonary Surfactant Associated ProteinC cite web url http www.physics.uwaterloo.ca research zleonenko data amyloidosis 20review.pdf title Surfactant ProteinC SP C Mini Review author Hane F authorlink coauthors date format work publisher www.physics.uwaterloo.ca pages language archiveurl archivedate quote Covers structure, function, pathologies and synthesis of SP C accessdate ... Protein domains ... more details
PBB geneid 10544 Endothelial proteinC receptor EPCR also known as activated proteinC receptor APC receptor ... proteinC activated proteinC receptor journal J Biol Chem volume 269 issue 42 pages 26486 91 year ... cell proteinC receptor EPCR journal FEBS Lett volume 458 issue 1 pages 77 80 year 1999 month ... Gene PROCR proteinC receptor, endothelial EPCR url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ... C , a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N glycosylated type I membrane protein that enhances the activation of proteinC. ref name ... web title Entrez Gene PROCR proteinC receptor, endothelial EPCR url http www.ncbi.nlm.nih.gov sites ... proteinC receptor gene and thrombophilia. journal Thromb. Haemost. volume 98 issue 3 pages 564 ... cite journal author Laszik Z, Mitro A, Taylor FB, et al. title Human proteinC receptor is present primarily on endothelium of large blood vessels implications for the control of the proteinC pathway ... author Ye X, Fukudome K, Tsuneyoshi N, et al. title The endothelial cell proteinC receptor EPCR functions as a primary receptor for proteinC activation on endothelial cells in arteries, veins, and capillaries ... implications of the intron exon organization of the human endothelial cell proteinC activated proteinC receptor EPCR gene comparison with the structure of CD1 major histocompatibility complex ... of the human endothelial proteinC receptor gene. journal Gene volume 238 issue 2 pages 367 73 ... PF, Smirnov MD, Esmon CT title Mechanisms by which soluble endothelial cell proteinC receptor modulates proteinC and activated proteinC function. journal J. Biol. Chem. volume 275 issue 8 pages ..., Esmon CT title Metalloproteolytic release of endothelial cell proteinC receptor. journal J. Biol ... author Liaw PC, Mather T, Oganesyan N, et al. title Identification of the proteinC activated proteinC binding sites on the endothelial cell proteinC receptor. Implications for a novel mode of ligand ... more details
PBB geneid 5104 ProteinC inhibitor PCI, SERPINA5 is a ser ine p rotease in hibitor serpin which limits the expression of proteinC an anticoagulant . An N terminal fragment of PCI is a possible serum ... Biomarkers ref Interactions ProteinC inhibitor has been shown to Proteinprotein interaction interact ... formation between proteinC inhibitor and prostate specific antigen in vitro and in human semen journal ... and its molecular interaction with prostate specific antigen and proteinC inhibitor journal Eur. J ... oclc id url language format accessdate laysummary laysource laydate quote ref ProteinC ref name ... month Dec. title Activated proteinCproteinC inhibitor complex formation characterization of a neoepitope ... proteinC inhibitor in vitro and in vivo journal Blood volume 74 issue 2 pages 722 8 publisher location ... of human proteinC inhibitor gene in HepG2 cells and its androgen dependent expression ... of a genetic polymorphism of human plasma proteinC inhibitor PCI genetic survey utilizing ... author Laurell M, Christensson A, Abrahamsson PA, et al. title ProteinC inhibitor in human body ... coding for human proteinC inhibitor plasminogen activator inhibitor 3 . Assignment of the gene to chromosome ... of glycosaminoglycan recognition by proteinC inhibitor. journal Proc. Natl. Acad. Sci. U.S.A. volume ... of plasma proteinC inhibitor. journal Thromb. Res. volume 55 issue 3 pages 369 84 ... ProteinC inhibitor from human plasma characterization of native and cleaved inhibitor and demonstration ... Complex formation between urokinase and plasma proteinC inhibitor in vitro and in vivo. journal Blood ... Y, Nishioka J, et al. title Characterization of a cDNA for human proteinC inhibitor. A new member ... formation between proteinC inhibitor and prostate specific antigen in vitro and in human semen ... by proteinC inhibitor and localization of proteinC inhibitor to spermatozoa. journal Am. J. Physiol ..., Fern ndez JA, Greengard JS, et al. title ProteinC inhibitor is expressed in tubular cells of human ... more details
Other uses PKC disambiguation infobox enzyme Name Protein kinase C EC number 2.7.11.13 CAS number 141436 78 4 IUBMB EC number 2 7 11 13 GO code 0004702 image width caption Protein kinase C also known as PKC EC 2.7.11.13 is a family of protein kinase enzyme s that are involved in controlling the function of other protein s through the phosphorylation of hydroxyl groups of serine and threonine amino .... ref name pmid7737456 cite journal author Nishizuka Y title Protein kinase C and lipid signaling ... C . On the other hand, atypical a PKCs including protein kinase M and isoforms require neither Ca sup 2 sup nor diacylglycerol for activation. The term protein kinase C usually refers to the entire ... require neither Ca sup 2 sup nor DAG for activation PRKCI PKC Gene PRKCI Protein kinase C, zeta ... kinase C enzymes is similar to that of protein kinase A , since it contains basic amino acids close ... C enzymes are translocated to the plasma membrane by RACK protein s membrane bound receptor for activated protein kinase C proteins . The protein kinase C enzymes are known for their long term activation ... acid secretion Pathology Protein kinase C, activated by tumor promoter phorbol ester, may phosphorylate ... by Protein Kinase C Controls c Jun mediated Activation of Transcription journal J. Biol. Chem. volume ... ref or interfere with other phenomena. Inhibitors Protein kinase C inhibitors, such as ruboxistaurin ... journal author Anderson PW, McGill JB, Tuttle KR title Protein kinase C beta inhibition the promise ... References Reflist 2 External links Commons category multi Protein kinase C PKC activators MeshName protein kinase c Serine threonine specific protein kinases DEFAULTSORT Protein Kinase C Category EC 2.7.11 Category Protein kinases ca Prote na cinasa C cs Proteinkin za C de Proteinkinase .... ref name pmid9601053 cite journal author Mellor H, Parker PJ title The extended protein kinase C superfamily journal Biochem. J. volume Pt 2 issue pages 281 92 series 332 year 1998 pmid 9601053 doi ... more details
PBB geneid 1401 C reactive protein CRP is a protein found in the blood, the levels of which rise in response to inflammation i.e. C reactive protein is an acute phase protein . Its physiological role is to bind ... or proteinC . C reactive protein was the first pattern recognition receptor PRR to be identified ... in innate immunity from C reactive protein to the long pentraxin PTX3 journal J. Clin. Immunol ... , ref cite journal author Pradhan AD title C reactive protein, interleukin 6, and risk of developing ... first5 PM issue 3 ref ref cite journal author Dehghan A title Genetic variation, C reactive protein ... author John Danesh title C reactive protein and other circulating markers of inflammation in the prediction ... MC, Kolstoe SE, Thompson D, Wood SP title Targeting C reactive protein for the treatment of cardiovascular ... in men and women with elevated C reactive protein journal N. Engl. J. Med. volume 359 issue 21 pages ... Emberson, Jonathan Emberson, Jonathan Emberson title C reactive protein concentration and the vascular ... P, Sillesen H, Nordestgaard BG title Genetically elevated C reactive protein and ischemic vascular disease ... St Onge MP, Zhang S, Darnell B, Allison DB title Baseline serum C reactive protein is associated with lipid ... C reactive protein and the risk of incident colorectal cancer journal Journal of the American Medical ... and molar concentration.png thumb 450px Reference ranges for blood tests , showing C reactive protein ..., Olshaker JS title The C reactive protein journal J Emerg Med volume 17 issue 6 pages 1019 25 year 1999 ... Lloyd Jones DM, Liu K, Tian L, Greenland P title Narrative review assessment of C reactive protein ... reactive protein.png C reactive protein gallery References Reflist 30em External links MedlinePlusEncyclopedia 003356 C reactive protein http www.americanheart.org presenter.jhtml?identifier 4648 Inflammation, Heart Disease and Stroke The Role of C Reactive Protein American Heart Association MeshName C Reactive Protein PDB Gallery geneid 1401 Albumins Acute phase proteins Immunologic techniques and tests ... more details
PBB geneid 5590 Protein kinase C, zeta PKC , also known as PRKCZ , is an enzyme that in humans is encoded ..., Serrano PA, Leitges M, Libien JM, Weinstein G, Tcherapanov A, Sacktor TC title Protein kinase M zeta synthesis from a brain mRNA encoding an independent protein kinase C zeta catalytic domain. Implications ... by isoforms of protein kinase C journal Biochem. Biophys. Res. Commun. volume 307 issue ... C isotypes controlled by phosphoinositide 3 kinase through the protein kinase PDK1 journal Science journal ... GTPases Rac and Cdc42 to atypical protein kinase C journal Genes Cells volume 6 issue 2 pages 107 ... W year 1999 month Jul. title Identification of Src as a novel atypical protein kinase C interacting ... apoptosis, interacts selectively with the atypical isoforms of protein kinase C journal Cell volume ... M C, Van Blitterswijk J year 2000 month Jan. title 14 3 3 isotypes facilitate coupling of protein ... protein involved in axonal outgrowth is a protein kinase C zeta interacting protein journal J. Cell ... Protein kinase C micro is regulated by the multifunctional chaperon protein p32 journal J. Biol ..., a new target of the atypical protein kinase C isoforms in mitogenic signaling journal Mol. Cell ... CD title The use of fluorescent phorbol esters in studies of protein kinase C membrane interactions ... compounds that regulate the activity of protein kinase C. journal Curr. Med. Chem. volume 11 issue ... regulatory domain, followed by a hinge region and a C terminus C terminal catalytic domain. Second ... catalytic protein kinase activity. PKM zeta, a brain specific isoform of PKC zeta generated ... thought of as being a cleavage product of full length PKC , an atypical isoform of protein kinase C PKC . Like other PKC isoforms, PKC is a serine threonine kinase that adds phosphate groups to target protein s. It is atypical in that unlike other PKC isoforms, PKC does not require calcium or diglyceride ... author Ling D, Benardo L, Serrano P, Blace N, Kelly M, Crary J, Sacktor T title Protein kinase ... more details
orphan date October 2011 Infobox protein family Symbol EcoEI R C Name EcoEI R C image width caption Pfam PF08463 Pfam clan InterPro IPR013670 SMART PROSITE MEROPS SCOP TCDB OPM family OPM protein CAZy CDD In molecular biology, the EcoEI R proteinC terminal domain is a protein domain found at the C terminus of both the R subunit of type I restriction enzymes and the Res subunit of type III restriction enzymes. The type I enzymes include EcoEI, which recognises 5 GAGN 7 ATGC 3 the R protein HsdR is required for both nuclease and ATPase activity. ref name pmid8412658 cite journal author Murray NE, Daniel AS, Cowan GM, Sharp PM title Conservation of motifs within the unusually variable polypeptide sequences of type I restriction and modification enzymes journal Mol. Microbiol. volume 9 issue 1 pages 133 43 year 1993 month July pmid 8412658 doi 10.1111 j.1365 2958.1993.tb01675.x url ref ref name pmid10449767 cite journal author Makovets S, Doronina VA, Murray NE title Regulation of endonuclease activity by proteolysis prevents breakage of unmodified bacterial chromosomes by type I restriction enzymes journal Proc. Natl. Acad. Sci. U.S.A. volume 96 issue 17 pages 9757 62 year 1999 month August pmid 10449767 pmc 22283 doi 10.1073 pnas.96.17.9757 url ref References reflist InterPro content IPR013670 Category Protein families Category Protein domains ... more details
Infobox protein family Symbol Cytochrom C asm Name Cytochrome C assembly protein image width caption Pfam PF01578 Pfam clan CL0328 InterPro IPR002541 SMART PROSITE MEROPS SCOP TCDB 9.B.14 OPM family OPM protein CAZy CDD In molecular biology, the cytochrome c assembly protein family includes various protein s involved in cytochrome c assembly from mitochondria and bacteria. Members of this family include CycK from Rhizobium leguminosarum , ref name pmid7665469 cite journal author Delgado MJ, Yeoman KH, Wu G, Vargas C, Davies AE, Poole RK, Johnston AW, Downie JA title Characterization of the cycHJKL genes involved in cytochrome c biogenesis and symbiotic nitrogen fixation in Rhizobium leguminosarum journal J. Bacteriol. volume 177 issue 17 pages 4927 34 year 1995 month September pmid 7665469 ... genes required for cytochrome c maturation journal J. Bacteriol. volume 177 issue 15 pages 4321 6 ... Page MD, Pearce DA, Norris HA, Ferguson SJ title The Paracoccus denitrificans ccmA, B and C genes cloning and sequencing, and analysis of the potential of their products to form a haem or apo c type cytochrome .... This transporter may be necessary for transport of some component needed for cytochrome c assembly. One member, R. leguminosarum CycK, contains a putative haem binding protein motif motif . ref name pmid7665469 cite journal author Delgado MJ, Yeoman KH, Wu G, Vargas C, Davies AE, Poole RK, Johnston AW, Downie JA title Characterization of the cycHJKL genes involved in cytochrome c biogenesis ... a putative haem binding motif and is a proposed ABC transporter with c type haem as its proposed ... it seems unlikely that all members of this family transport haem or c type apocytochromes because ... DA, Norris HA, Ferguson SJ title The Paracoccus denitrificans ccmA, B and C genes cloning and sequencing, and analysis of the potential of their products to form a haem or apo c type cytochrome transporter ... pmid 9043133 doi url ref References reflist InterPro content IPR002541 Category Protein families ... more details
PBB geneid 4607 Cardiac Myosin binding proteinC cMyBP C , also known as MYBPC3 , is a protein which ... proteinC, cardiac url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... ng0793 311 url ref Function MYBPC3 encodes the cardiac isoform of myosin binding proteinC. Myosin binding proteinC is a myosin associated protein found in the cross bridge bearing zone C region ... in the myosin binding proteinC gene journal Rev Port Cardiol volume 24 issue 12 pages 1463 76 year ... MYBPC3 cardiac myosin binding proteinC variant associated with cardiomyopathies in South Asia journal ... R, Offer G title The interaction of Cprotein with heavy meromyosin and subfragment 2. journal Biochem ... C, Feng IN title Effect of Cprotein on actomyosin ATPase. journal Biochim. Biophys. Acta volume ... Watkins H, Conner D, Thierfelder L, et al. title Mutations in the cardiac myosin binding proteinC gene ..., Bercovici J, et al. title Cardiac myosin binding proteinC gene splice acceptor site mutation is associated ... cardiac myosin binding proteinC gene MYBPC3 and identification of mutations predicted to produce truncated ... Novel splice donor site mutation in the cardiac myosin binding proteinC gene in familial hypertrophic ... caused by mutations in the cardiac myosin binding proteinC gene journal J. Med. Genet. volume ... and in the cardiac myosin binding proteinC genes in a family with hypertrophic cardiomyopathy journal ... A, Labeit S title Phosphorylation switches specific for the cardiac isoform of myosin binding proteinC a modulator of cardiac contraction? journal EMBO J. volume 14 issue 9 pages 1952 60 year 1995 month ..., Hengstenberg C, Beckmann JS, Guicheney P, Dufour C, Bercovici J, Dausse E, Berebbi Bertrand I, Wisnewsky C, Pulvenis D title Mapping of a novel gene for familial hypertrophic cardiomyopathy to chromosome ... adenosine monophosphate cAMP dependent protein kinase Protein kinase A PKA upon adrenergic stimulation ... author Cardim N, Perrot A, Santos S, Morgado P, P dua M, Ferreira S, Reis RP, Monteiro C, Ferreira ... more details
PBB geneid 6440 Pulmonary surfactant associated proteinC is a protein that in humans is encoded by the SFTPC ... title The pulmonary surfactant proteinC SP C precursor is a type II transmembrane protein journal Biochem ... domain containing C terminal part of pro surfactant proteinC binds to an unfolded poly val ..., pulmonary associated proteinC url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 6440 accessdate ref Pulmonary surfactant associated proteinC is a membrane protein ... P rez Gil J title Lipid protein interactions of hydrophobic proteins SP B and SP C in lung surfactant ... and post translational processing of surfactant proteinC journal Pediatric pathology & molecular medicine ... molecular weight pulmonary surfactant protein SP C journal Biochemistry volume 29 issue 24 pages ... proteinC genetic homogeneity and expression in RDS comparison with other species journal Exp. Lung ... author Nogee LM title A mutation in the surfactant proteinC gene associated with familial interstitial ... dysfunction type 2. Humans and animals born lacking SP C tend to develop progressive interstitial pneumonitis. The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB ..., Curstedt T, Robertson B title Artificial surfactants based on analogues of SP B and SP C journal Pediatric ... journal author Nogee LM title Alterations in SP B and SP C expression in neonatal lung disease journal ... display authors 3 last4 Johnen first4 G. last5 Ochs first5 M. last6 Rieger first6 C. last7 Mulugeta ... surfactant associated polypeptides SP C is a lipopeptide with two palmitoylated cysteine residues ... SP C genes encoding human pulmonary surfactant proteolipid journal J. Biol. Chem. volume 263 issue 21 ... first6 T cite journal author Warr RG title Low molecular weight human pulmonary surfactant protein ... author Glasser SW title Altered stability of pulmonary surfactant in SP C deficient mice journal ... Associated Protein B Membrane proteins The PBB Controls template provides controls for Protein ... more details
activator proteins of APC c and therefore contributes to the regulation of protein degradation ...Orphan date April 2012 protein Name SCF Fbw7 ubiquitin ligase complex image SCF Fbw7 .PNG width caption ... Cdh1 is one of the substrate Adaptor proteins adaptor protein of the anaphase promoting ... C, Cdh1 regulates the activity and substrate specificity of this E3 ubiquitin ligase. Introduction ... in a C box dependent mechanism to the APC for ubiquination and subsequent proteolysis. Cdh1 is required ..., L. Hou, X. Huang, Z. Wei, E. Klann, P.Zhang year 2008 title The adaptor protein of the anaphase promoting ... ncb1768 ref Function The anaphase promoting complex cylosome APC c is an Ubiquitin ligase ubiquitin ... with APC c and build the active ligase APC sup Cdh1 sup . ref name cite journal doi 10.1038 nrm1988 ... , another APC c co activator. ref name Engelbert cite journal author Dirk Engelbert year 2007 title ... of mitotic CDKs which are inactivated through ubiquitin dependent pathways. The protein ... repeat protein like Cdh1. The model for Cdh1 can be found on the webpage of SWISS MODEL Repository ... three dimensional protein structure homology models. journal Nucleic Acids Res. volume 32 pages D230 ... on the cdh1 protein of Saccharomyces cerevisiae also named Hct1. Cdh1 is a cdc20 homolog and is Frizzy related Drosophila . The protein sequence of cdh1 consists of 566 amino acid s and has a molecular weight of 62.8 kDa. Cdh1 comprises different Protein domain domains important for its proper function, when it interacts with the anaphase promoting complex APC c complex and the various Enzyme ... www.uniprot.org uniprot P53197 accessdate 2010 04 10 ref Activation and APC c Binding In the N terminus N terminal region at amino acid position 55 61 the cdh1 protein contains a C Box structural motif motif , which is required for the association with the APC c complex. Especially the residue R56 seems to be important for the binding to APC c in vitro and Cdh1 function in vivo . ref name Uniprot ... more details
March pmid 420821 doi 10.1021 bi00572a026 ref Function The best characterized function of Protein S is its role in the anti coagulation pathway, where it functions as a cofactor to ProteinC in the inactivation ... of activated proteinC journal J. Biol. Chem. volume 268 issue 4 pages 2872 7 publisher ... of the proteinC anticoagulant system journal Thromb. Haemost. volume 66 issue 1 pages ... und Diagnostik der heredit ren Defekte von Antithrombin III, ProteinC und Protein S language German ..., proteinc and protein S journal Hamostaseologie volume 22 issue 2 pages 14 24 year 2002 pmid 12193972 ... doi cite journal author Maillard C, Berruyer M, Serre CM, et al. title Protein S, a vitamin K dependent ... A novel functional assay of proteinC in human plasma and its comparison with amidolytic and anticoagulant ... acid in the first epidermal growth factor like domain of proteinC. Its role in Ca2 binding and biological ...PBB geneid 5627 Protein S is a vitamin K dependent plasma glycoprotein synthesized in the endothelium. In the circulation, Protein S exists in two forms a free form and a complex form bound to complement system complement protein C4b binding protein C4BP . In humans, protein S is encoded by the PROS1 ... B, Stenflo J, Wydro R title Isolation and sequence of the cDNA for human protein S, a regulator ... dependent plasma proteins C and S are located on chromosomes 2 and 3, respectively journal Somat. Cell ... url ref In 1979, researchers in Seattle , Washington first discovered protein S and arbitrarily ... X Stuart factor , and protein S journal Biochemistry volume 16 issue 4 pages 698 706 year 1977 ... RG, Davie EW title Characterization of protein S, a gamma carboxyglutamic acid containing protein .... ref name pmid18695379 cite journal author Castoldi E, Hackeng TM title Regulation of coagulation by protein ... 18695379 doi 10.1097 MOH.0b013e328309ec97 url ref Protein S can bind to negatively charged phospholipids via the carboxylated Gla domain GLA domain . This property allows Protein S to function in the removal ... more details
angle s in the peptide bond determine the local shape assumed by the protein backbone. ref Murray et al ., p. 31. ref The end of the protein with a free carboxyl group is known as the C terminus ...About a class of molecules protein as a nutrient Protein nutrient other uses pp semi indef File Myoglobin.png thumb right A representation of the 3D structure of the protein myoglobin showing colored alpha helix alpha helices . This protein was the first to have its structure solved by X ray crystallography ... folded into a globular protein globular or fibrous protein fibrous form, facilitating a biological ... . The peptide sequence sequence of amino acids in a protein is defined by the DNA sequence sequence ... archaea pyrrolysine . Shortly after or even during synthesis, the residues in a protein are often ... to form stable protein complex es. Like other biological macromolecules such as polysaccharide ... acid s from food. Through the process of digestion , animals break down ingested protein into free amino acids that are then used in metabolism. Proteins may be protein purification purified from ... made possible a number of methods to facilitate purification. Methods commonly used to study protein ... chains in a protein that ultimately determines its three dimensional structure and its chemical reactivity ... linked in the protein chain, an individual amino acid is called a residue, and the linked series of carbon, nitrogen, and oxygen atoms are known as the main chain or protein backbone. ref Murray ... structures of the peptide bond that links individual amino acids to form a protein polymer The peptide .... The words protein , polypeptide, and peptide are a little ambiguous and can overlap in meaning. Protein is generally used to refer to the complete biological molecule in a stable tertiary structure ... structure conformation . Synthesis Main Protein biosynthesis Image Ribosome mRNA translation en.svg thumb A ribosome produces a protein using mRNA as template. File Genetic code.svg thumb The DNA ... more details
Pfam box Symbol SpA Name Protein A image Protein A 1DEE 1L6X.png width caption Structure of a domain of protein A as a three helix bundle binding to the heavy variable chain of a VH3 human Fab ref name ... JB, Silverman GJ. title Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab ... month May pmid 10805799 doi pmc 25840 ref left. Minimized protein A bound to Fc fragment of Rituximab ... April pmid 10754313 doi ref Pfam InterPro SMART PROSITE SCOP 1DEE TCDB OPM family OPM protein PDB PDB2 1dee , PDB2 1l6x Protein A is a 56 Atomic mass unit kDa MSCRAMM surface protein originally found ... and phagocytosis . Protein A antibody binding Protein A binds with high affinity to human IgG1 and IgG2 as well as mouse IgG2a and IgG2b. Protein A binds with moderate affinity to human IgM ... or IgD , nor will it react to mouse IgM, IgA or IgE. The capacity of protein A to bind antibodies with such high .... The protein A used for production of antibodies in bio pharmaceuticals is most commonly bound to a stationary phase chromatography resin. Other antibody binding proteins In addition to Protein A, other immunoglobulin binding bacterial proteins such as Protein G , Protein A G and Protein L are all ... Staphylococcus aureus utilizes Protein A, along with a host of other proteins and surface factors to aid its survival and, thus, virulence. Protein A helps inhibit phagocytic engulfment and acts as an immunological disguise. Mutants of S. aureus lacking protein A are more efficiently phagocytosed ... toxin. J. Exp. Med. 2003 197 1125 1139. ref Research Recombinant Staphylococcal Protein ... form of Protein A is called MabSelect. ref http www.gelifesciences.com aptrix upp00919.nsf Content 17D93C2E6A580E57C1257628001CE677 file 18114994AE.pdf ref Protein A is often coupled to other molecules .... Protein A is often immobilized onto a solid support and used as reliable method for purifying total IgG from crude protein mixtures such as blood serum serum or ascites fluid, or coupled with one ... more details
A binding protein is any protein that acts as an agent to Molecular binding bind two or more molecules together. Examples include DNA binding protein Single strand binding protein Telomere binding protein RNA binding protein Poly A binding protein Nuclear cap binding protein complex CREB binding protein Calcium binding protein Calcium binding protein 1 S100 calcium binding protein A1 TATA binding protein Actin binding protein Penicillin binding proteins Retinol binding protein Retinol binding protein 4 EP300 Binding immunoglobulin protein Odorant binding protein Lipopolysaccharide binding protein C4b binding protein Rap GTP binding protein Calmodulin binding proteins Iron binding proteins Thyroxine binding proteins Folate binding protein Sterol regulatory element binding protein GTP binding protein Retinaldehyde binding protein 1 Ccaat enhancer binding proteins Androgen binding protein Maltose binding protein Phosphatidylethanolamine binding protein 1 Syntaxin binding protein 3 Insulin like growth factor binding protein Methyl CpG binding domain protein 2 Growth hormone binding protein Vitamin D binding protein Syntaxin binding protein 2 Oxysterol binding protein E3 binding protein Iron responsive element binding protein Polypyrimidine tract binding protein Fatty acid binding protein Myosin binding proteinC, cardiac CPE binding protein Category Proteins biochem stub ... more details
ref ref Prieto C, De Las Rivas J 2006 . APID Agile Protein Interaction DataAnalyzer. Nucleic ... journal author De Las Rivas J, Fontanillo C editor1 last Lewitter editor1 first Fran title Proteinprotein ... forms a proteinprotein interaction with the ribonuclease protein. The contacts between the two proteins are shown as coloured patches. 250px Proteinprotein interactions occur when two or more protein s bind together, often to carry out their function biology biological function . Many ... molecular machines that are built from a large number of protein components organised by their proteinprotein interactions. Protein interactions have been studied from the perspectives of biochemistry ... or genetic epigenetic graph theory networks . Indeed, proteinprotein interactions are at the core ... cell are mediated to the inside of that cell by proteinprotein interactions of the signaling molecules ... and in many diseases e.g. cancer s . Proteins might interact for a long time to form part of a protein complex , a protein may be carrying another protein for example, from cytoplasm to cell nucleus nucleus or vice versa in the case of the nuclear pore importins , or a protein may interact briefly with another protein just to modify it for example, a protein kinase will add a phosphate to a target protein . This modification of proteins can itself change proteinprotein interactions. For example ..., proteinprotein interactions are of central importance for virtually every process in a living cell ... for new therapeutic approaches. Methods to investigate proteinprotein interactions Main Methods to investigate proteinprotein interactions As proteinprotein interactions are so important there are a multitude ... such as yeast two hybrid screening can be used to detect novel proteinprotein interactions. Visualization ... where each point represents a protein and each blue line between them is an interaction. 200px Visualization of proteinprotein interaction networks is a popular application of scientific visualization ... more details
http www.proteopedia.org wiki index.php Rop protein Rop also known as repressor of primer is a small homodimeric four helix bundle protein formed by the antiparallel interaction of two helix turn helix monomers. The protein is expressed in Escherichia coli as a mechanism for regulating the gene copy number s of plasmid s. The Rop protein s structure has been solved to high resolution. ref Banner Due to its small size and known structure, Rop has been used in protein design work to rearrange its helical topology and reengineer its loop regions. ref Kresse In general, the four helix bundle has been extensively used in de novo protein design work as a simple model to understand the relationship between amino acid sequence and structure. References note Banner Banner DW, Kokkinidis M, Tsernoglou D. 1987 . Structure of the ColE1 rop protein at 1.7 A resolution. J Mol Biol 196 3 657 75. note Kresse Kresse HP, Czubayko M, Nyakatura G, Vriend G, Sander C, Bloecker H. 2001 . Four helix bundle topology re engineered monomeric Rop protein variants with different loop arrangements. Protein Eng 14 11 897 901. Category Proteins protein stub de G Protein Rop ... more details
Protein splicing is an intramolecular reaction of a particular protein in which an internal protein segment called an intein is removed from a precursor protein with a ligation of C terminal and N terminal external proteins called extein s on both sides. The splicing junction of the precursor protein is mainly a cysteine or a serine , which are amino acid s containing a nucleophilic side chain . The protein splicing reactions which are known now do not require exogenous cofactors or energy sources such as adenosine triphosphate ATP or guanosine triphosphate GTP . Normally, splicing is associated only with Splicing genetics pre mRNA splicing . Types of inteins The type of the splicing proteins is categorized into four classes maxi intein, mini intein, trans splicing intein, and alanine intein. The maxi inteins are N and C terminal splicing domains containing an endonuclease domain. The mini inteins are typical N and C terminal splicing domains however, the endonuclease domain is not present. The trans splicing inteins are split inteins which are divided into N termini and C termini. Alanine inteins have the splicing junction of an alanine instead of a cysteine or a serine, in both of which the protein splicing occurs. History Protein splicing was reported by two groups Anraku and Stevens in 1990. They both discovered a Saccharomyces cerevisiae VMA1 in a precursor of a vacuolar H sup sup ATPase . The amino acid sequence of the N and C termini corresponded to 70 of that of a vacuolar H sup sup ATPase from other organisms, while the amino acid sequence of the central position corresponded to 30 of that of the yeast HO nuclease External links http starokadomskyy.narod.ru work intein eng.html Short review http starokadomskyy.narod.ru Protein splicing eng.pdf Starokadomskyy PL. Protein Splicing, 2007 http www.neb.com neb inteins.html Protein splicing mechanism and intein structure MeshName Protein Splicing Category Proteins Category Protein biosynthesis de Proteinsplei en fa ... more details
. Protein S deficiency is the underlying cause of a small proportion of cases of disseminated ... Protein S Deficiency And Thrombophilia at proteinsdeficiency.com http www.med.uiuc.edu hematology PtProtS.htm Protein S Deficiency University of Illinois Articles cite journal author ten Kate ... PROS1 c.1113T GG frameshift mutation in a family with mixed type I type III protein S deficiency journal ... more details
Unreferenced date December 2009 RACK is an acronym for Receptor for Activated C Kinase and is responsible for the binding of active forms of the protein kinase C PKC family of enzyme s. See also RICK protein , Receptor for Inactive C Kinase. There are different RACKs for different isoforms of PKC, which thus mediate differential subcellular targeting of the isoforms. Inactive forms of PKC occlude the RACK binding site with a pseudo RACK peptide sequence RACKs share 47 identity with the beta subunit of G proteins RACKs represent one of the many ways in which a cell can use signalling complexes to manipulate the specificity of interactions within intracellular signalling cascades DEFAULTSORT Rack Protein Category Proteins Protein stub ... more details
distinguish G proteinProtein G is an immunoglobulin binding protein expressed in group C and G Streptococcal bacteria much like Protein A but with differing specificities. It is a 65 kDa G148 protein G and a 58 kDa C40 protein G ref name Sjobring 1991 cell surface protein that has found application in purifying antibodies through its binding to the Fc region. The native molecule also binds albumin, however, because serum albumin is a major contaminant of antibody sources, the albumin binding site has been removed from Recombinant DNA recombinant forms of Protein G. Other antibody binding proteins In addition to Protein G, other immunoglobulin binding bacterial proteins such as Protein A , Protein A G and Protein L are all commonly used to purify, immobilize or detect immunoglobulins. Each of these immunoglobulin binding proteins has a different antibody binding profile in terms of the portion of the antibody that is recognized and the species and type of antibodies it will bind. Folding of Protein G, B1 Domain An Ab initio quantum chemistry methods ab initio simulation of the protein G B1 domain demonstrates that, as earlier results suggested, this protein initiates folding via a nucleation event in the hydrophobe hydrophobic core Amino acid residues followed by small adjustments. ref name Kmiecik 1994 The folding events are as follows a Beta hairpin hairpin is formed, stabilized by residues W43, Y45, and F52. Residue contacts between residue F30, in an Alpha helix helix ... in a globular protein . The protein G B1 domain is aka. GB1 often used as part of a fusion protein ... L, Kastern W, et al title Streptococcal protein G. Gene structure and protein binding properties journal ... cite journal author Kmiecik S, Kolinski A title Folding pathway of the b1 domain of protein G explored ... Yuan Cheng, Dinshaw J Patel, An efficient system for small protein expression and refolding, Biochemical ... Category Proteins de Protein G es Prote na G Streptococcus ru G ... more details
by the structures of the isomerase domain s of some of its members. A protein family is a group of evolution arily related protein s, and is often nearly synonymous with gene family . The term protein family should not be confused with Family biology family as it is used in taxonomy. Proteins ... protein structure three dimensional structures , functions, and significant sequence similarity ... tool for identifying the members of protein families. Currently, over 60,000 protein families have been defined, ref V.Kunin, I. Cases, A.J. Enrigh, V. de Lorenzo, C.A. Ouzounis, Myriads of protein families ... ambiguity in the definition of protein family leads different researchers to wildly varying numbers. Terminology and usage As with many biological terms, the use of protein family is somewhat context ..., Dayhoff introduced the concept of a protein superfamily. ref Dayhoff, M.O., Computer analysis of protein sequences, Fed. Proc. 33, 2314 2316, 1974. ref ref Dayhoff, M.O., McLaughlin, P.J., Barker, W.C., and Hunt, L.T., Evolution of sequences within protein superfamilies,Naturwissenschaften 62, 154 161, 1975. ref ref Dayhoff, M.O., The origin and evolution of protein superfamilies, Fed. Proc. 35, 2132 2138, 1976. ref Other terms such as protein class , protein group , and protein sub family ... these terms are being used in a particular context. Protein domains and motifs The concept of protein family was conceived at a time when very few protein structures or sequences were known at that time, primarily small, single domain proteins such as myoglobin , hemoglobin , and cytochrome c . Since ... units or Protein domain domains . Due to evolutionary shuffling , different domains in a protein have evolved independently. This has led, in recent years, to a focus on families of protein domains ... at the end of this article . Regions of each protein have differing functional constraints features critical to the structure and function of the protein . For example, the active site of an enzyme ... more details
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