, kDa 136 BR aggrecan , kDa 220, the major proteoglycan in cartilage keratan sulfate fibromodulin , kDa 42 BR lumican , kDa 38 Certain members are considered members of the small leucine rich proteoglycan ... endoplasmic reticulum . Glycosylation of the proteoglycan occurs in the Golgi apparatus in multiple ... by glycosyl transferase. The completed proteoglycan is then exported in secretory vesicle biology ..., depending upon the type of proteoglycan that is not degraded. References reflist External links ... more details
File Protein ACAN PDB 1tdq.png thumb Structure of the protein core of aggrecan or chondroitin sulfate proteoglycan 1 Chondroitin sulfate proteoglycans CSPGs are proteoglycans consisting of a protein core and a chondroitin sulfate side chain. They are known to be structural components of a variety of human tissues, including cartilage , and also play key roles in neural development and glial scar formation. They are known to be involved in certain cell processes, such as cell adhesion , cell growth, receptor binding, cell migration, and interaction with other extracellular matrix constituents. ref name Rhodes cite pmid 14690476 ref They are also known to interact with laminin , fibronectin , tenascin , and collagen . ref name Rhodes CSPGs are generally secreted from cells. Importantly, CSPGs are known to inhibit axon regeneration after spinal cord injury. CSPGs contribute to glial scar formation post injury, acting as a barrier against new axons growing into the injury site. ref name Justin cite pmid 21848846 ref CSPGs play a crucial role in why spinal cord injuries are so debilitating and often incurable. General structure Chondroitin sulfate proteoglycans are composed of a core protein and a sugar side chain. The core protein is generally a glycoprotein , and the side chains are glycosaminoglycan GAG sugar chains attached through a covalent bond . ref name Rhodes The GAG side chains are of different lengths depending on the CSPG. Each GAG chain consists of a linear pattern of alternating monosaccharide units uronic acid and either N acetylglucosamine or N acetylgalactosamine . ref name Rhodes Types of CSPGs The following CSPGs have been identified Aggrecan CSPG1 Versican CSPG2 Neurocan CSPG3 CSPG4 melanoma associated chondroitin sulfate proteoglycan, NG2 CSPG5 SMC3 CSPG6, structural maintenance of chromosomes 3 Brevican CSPG7 CD44 CSPG8, cluster of differentiation 44 Phosphacan Neurocan, brevican, versican, and aggrecan all share similar N terminal and C terminal d ... more details
enzyme Name N acetylgalactosaminyl proteoglycan 3 beta glucuronosyltransferase EC number 2.4.1.226 CAS number 269077 98 7 IUBMB EC number 2 4 1 226 GO code 0050510 image width caption In enzymology , a N acetylgalactosaminyl proteoglycan 3 beta glucuronosyltransferase EC number 2.4.1.226 is an enzyme that catalysis catalyzes the chemical reaction UDP alpha D glucuronate N acetyl beta D galactosaminyl 1 4 beta D glucuronosyl proteoglycan math rightleftharpoons math UDP beta D glucuronosyl 1 3 N acetyl beta D galactosaminyl 1 4 beta D glucuronosyl proteoglycan The 3 substrate biochemistry substrates of this enzyme are UDP alpha D glucuronate , N acetyl beta D galactosaminyl 1 4 beta D glucuronosyl , and proteoglycan , whereas its 3 product chemistry products are uridine diphosphate UDP , beta D glucuronosyl 1 3 N acetyl beta D galactosaminyl 1 4 , and beta D glucuronosyl proteoglycan . This enzyme belongs to the family of glycosyltransferase s, specifically the hexosyltransferases. The systematic name of this enzyme class is alpha D glucuronate N acetyl beta D galactosaminyl 1 4 beta D glu curonosyl proteoglycan 3 beta glucuronosyltransferase . This enzyme is also called chondroitin glucuronyltransferase II . This enzyme participates in chondroitin sulfate biosynthesis and glycan structures biosynthesis 1 . References reflist 1 cite journal author Kitagawa H, Uyama T, Sugahara K date 2001 title Molecular cloning and expression of a human chondroitin synthase journal J. Biol. Chem. volume 276 pages 38721&ndash 6 pmid 11514575 doi 10.1074 jbc.M106871200 issue 42 cite journal author DeAngelis PL, Padgett McCue AJ date 2000 title Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F journal J. Biol. Chem. volume 275 pages 24124&ndash 9 pmid 10818104 doi 10.1074 jbc.M003385200 issue 31 cite journal author Ninomiya T, Sugiura N, Tawada A, Sugimoto K, Watanabe H, Kimata K date 2002 title Molecular cloning and characterization of chondroitin ... more details
enzyme Name N acetylglucosaminyl proteoglycan 4 beta glucuronosyltransferase EC number 2.4.1.225 CAS number 145539 84 0 IUBMB EC number 2 4 1 225 GO code 0050509 image width caption In enzymology , a N acetylglucosaminyl proteoglycan 4 beta glucuronosyltransferase EC number 2.4.1.225 is an enzyme that catalysis catalyzes the chemical reaction UDP alpha D glucuronate N acetyl alpha D glucosaminyl 1 4 beta D glucuronosyl proteoglycan math rightleftharpoons math UDP beta D glucuronosyl 1 4 N acetyl alpha D glucosaminyl 1 4 beta D glucuronosyl proteoglycan The 3 substrate biochemistry substrates of this enzyme are UDP alpha D glucuronate , N acetyl alpha D glucosaminyl 1 4 beta D glucuronosyl , and proteoglycan , whereas its 3 product chemistry products are uridine diphosphate UDP , beta D glucuronosyl 1 4 N acetyl alpha D glucosaminyl 1 4 , and beta D glucuronosyl proteoglycan . This enzyme belongs to the family of glycosyltransferase s, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP alpha D glucuronate N acetyl alpha D glucosaminyl 1 4 beta D glucuronosyl proteoglycan 4 beta glucuronosyltransferase . Other names in common use include N acetylglucosaminylproteoglycan beta 1,4 glucuronyltransferase , and heparan glucuronyltransferase II . This enzyme participates in heparan sulfate biosynthesis and glycan structures biosynthesis 1 . References reflist 1 cite journal author K, Lindahl U, Kusche Gullberg M date 2000 title The EXT1 EXT2 tumor suppressors catalytic activities and role in heparan sulfate biosynthesis journal EMBO. Rep. volume 1 pages 282&ndash 6 pmid 11256613 doi 10.1093 embo reports kvd045 issue 3 pmc 1083719 cite journal author Lind T, Tufaro F, McCormick C, Lindahl U, Lidholt K date 1998 title The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate journal J. Biol. Chem. volume 273 pages 26265&ndash 8 pmid 9756849 doi 10.1074 jbc.273.41.26265 issue 41 enzyme ... more details
Testican is a type of proteoglycan . Types include SPOCK1 Testican 1 SPOCK2 Testican 2 Glycoproteins Category Proteoglycans biochemistry stub ... more details
SLRP may be an abbreviation for Soluble low density lipoprotein receptor related protein Small leucine rich repeat protein Small leucine rich repeat proteoglycan disambig ... more details
MCSP can refer to Canada USA Mathcamp Merlin Capability Sustainment Plus Mid Life Update of Merlin see Lockheed Martin U.K. and AgustaWestland EH101 Melanoma associated chondroitin sulfate proteoglycan , a tumour marker Member of the Chartered Society of Physiotherapy Minimum cost spanning tree , the lowest costing way to construct a spanning tree graph. disambig ... more details
PBB geneid 1464 Chondroitin sulfate proteoglycan 4 , also known as melanoma associated chondroitin sulfate proteoglycan MCSP or neuron glial antigen 2 NG2 , is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene . ref name pmid8790396 cite journal author Pluschke G, Vanek M, Evans A, Dittmar T, Schmid P, Itin P, Filardo EJ, Reisfeld RA title Molecular cloning of a human melanoma associated chondroitin sulfate proteoglycan journal Proc Natl Acad Sci U S A volume 93 issue 18 pages 9710 5 year 1996 month Oct pmid 8790396 pmc 38494 doi 10.1073 pnas.93.18.9710 ref ref name ... CSPG4 chondroitin sulfate proteoglycan 4 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... s. It represents an integral membrane chondroitin sulfate proteoglycan expressed by human melanoma ... sulfate proteoglycan of human B cell lines binds to the complement protein C1q and inhibits complex ... author Eisenmann KM, McCarthy JB, Simpson MA, et al. title Melanoma chondroitin sulphate proteoglycan ... spanning proteoglycan NG2. journal J. Cell. Biochem. volume 79 issue 2 pages 213 24 year 2000 pmid ..., Pei D, Kang T, et al. title Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase ... B, Rosenthal A title A novel repeat in the melanoma associated chondroitin sulfate proteoglycan ... J title The proteoglycan NG2 is complexed with alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic ... S, et al. title Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human ... and hair follicle progenitor cells express melanoma associated chondroitin sulfate proteoglycan core ... NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin 3 and alpha3beta1 .... title Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms ..., et al. title Phosphorylation of NG2 proteoglycan by protein kinase C alpha regulates polarized membrane ... al. title Altered expression of the MCSP NG2 chondroitin sulfate proteoglycan in collagen VI deficiency ... more details
IGD can refer to Internet Gateway Device Protocol Internet Gateway Device as defined in UPnP . GD, lerici Gen ler Derne i , Progressive Young Association of Turkey Immunoglobulin D , an antibody protein involved in the maturation of B cell s. Intergobular domain , a region of the proteoglycan aggrecan that is susceptible to proteolytic cleavage Integrated Graphics Device, a Graphics processing unit integrated directly into the motherboard of a Personal Jew Nigger PC disambig de IGD it IGD ... more details
DCN may refer to Daily Commercial News , an Australian shipping newspaper first published in 1891 Decorin , a member of the proteoglycan family proteins Deputy Chief of Navy , Australia Direction des Constructions Navales , French shipbuilder Dorsal cochlear nucleus , a structure located on the brainstem Dynamic circuit network , a high performance computer network technology Data Communication Network , management network for telecommunication transport systems disambig de DCN fr DCN ... more details
External lamina is a structure similar to basal lamina that surrounds the sarcolemma of muscle cells. It is secreted by myocytes and consists primarily of Collagen type IV , laminin and perlecan heparan sulfate proteoglycan . Nerve cells, including perineurial cells and Schwann cells also have an external lamina like protective coating. ref Wheater s Functional Histology, 5th ed. Young, Lowe, Stevens and Heath. ref Adipocytes also have an external lamina References reflist Category Skin anatomy Category Histology med stub ... more details
enzyme Name protein xylosyltransferase EC number 2.4.2.26 CAS number 55576 38 0 IUBMB EC number 2 4 2 26 GO code 0030158 image width caption In enzymology , a protein xylosyltransferase EC number 2.4.2.26 is an enzyme that catalysis catalyzes the chemical reaction in which a beta D xylose xylosyl residue is transferred from UDP D xylose to the sidechain oxygen atom of a serine residue in a protein . This enzyme belongs to the family of glycosyltransferase s, specifically the pentosyltransferases. The systematic name of this enzyme class is UDP D xylose protein beta D xylosyltransferase . Other names in common use include UDP D xylose core protein beta D xylosyltransferase , UDP D xylose core protein xylosyltransferase , UDP D xylose proteoglycan core protein beta D xylosyltransferase , UDP xylose core protein beta D xylosyltransferase , uridine diphosphoxylose core protein beta xylosyltransferase , and uridine diphosphoxylose protein xylosyltransferase . This enzyme participates in the biosynthesis of chondroitin sulfate and glycan structures. References reflist 1 cite journal author Stoolmiller AC, Horwitz AL, Dorfman A date 1972 title Biosynthesis of the chondroitin sulfate proteoglycan. Purification and properties of xylosyltransferase journal J. Biol. Chem. volume 247 pages 3525&ndash 32 pmid 5030630 issue 11 cite journal author Gotting C, Kuhn J, Zahn R, Brinkmann T, Kleesiek K date 2000 title Molecular cloning and expression of human UDP d Xylose proteoglycan core protein beta d xylosyltransferase and its first isoform XT II journal J. Mol. Biol. volume 304 pages 517&ndash 28 pmid 11099377 doi 10.1006 jmbi.2000.4261 issue 4 enzyme stub Category EC 2.4.2 Category Enzymes of unknown structure ... more details
Orphan date February 2009 PBB geneid 5552 Serglycin also known as hematopoetic proteoglycan core protein or secretory granule proteoglycan core protein is a protein that in humans is encoded by the SRGN gene . ref name entrez cite web title Entrez Gene SRGN serglycin url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 5552 accessdate ref Function This gene encodes a protein best known as a hematopoietic stem cell hematopoietic cell granule cell biology granule proteoglycan. Proteoglycan s stored in the secretion secretory granules of many hematopoietic cells also contain a protease resistant peptide core, which may be important for neutralizing hydrolase hydrolytic enzyme s. This encoded protein was found to be associated with the macromolecular complex of granzyme s and perforin , which may serve as a mediator of granule mediated apoptosis . ref name entrez References reflist Further reading refbegin 2 cite journal author Schick BP title Regulation of expression of megakaryocyte and platelet proteoglycans. journal Stem Cells volume 14 Suppl 1 issue pages 220 31 year 2000 pmid 11012225 doi 10.1002 stem.5530140729 cite journal author Humphries DE, Nicodemus ... cite journal author Mattei MG, P rin JP, Alliel PM, et al. title Localization of human platelet proteoglycan ... mast cell secretory granule proteoglycan and comparison with the analogous rat and human cDNA. journal ... of a cDNA encoding a hemopoietic proteoglycan core protein. journal Nucleic Acids Res. volume 17 ... the peptide core of the secretory granule proteoglycan of human promyelocytic leukemia HL 60 cells ... platelet proteoglycan. journal Biochem. J. volume 255 issue 3 pages 1007 13 year 1989 pmid 3214420 ... that encodes the peptide core of the secretory granule proteoglycan of rat basophilic leukemia ... al. title Complete amino acid sequence of a human platelet proteoglycan. journal FEBS Lett. volume ..., secretion, and subcellular localization of serglycin proteoglycan in human endothelial cells ... more details
Orphan date February 2009 Chondroitinase treatment is a treatment of proteoglycan s, a Glycoprotein protein in the Interstitial fluid fluid among cells where among other things they affect neural activity communication, neuroplasticity plasticity . ref Cambridge Centre for Brain Repair, School of Clinical Medicine, Cambridge Centre for Brain Repair. http www.brc.cam.ac.uk Plasticity.htm Plasticity and the extracellular matrix. ref Chondroitinase treatment has been shown to allow adults vision to be restored as far as ocular dominance is concerned. ref cite journal author Hensch TK title Critical period mechanisms in developing visual cortex journal Curr. Top. Dev. Biol. volume 69 issue pages 215 37 year 2005 pmid 16243601 doi 10.1016 S0070 2153 05 69008 4 url http linkinghub.elsevier.com retrieve pii S0070 2153 05 69008 4 ref Moreover there is some evidence that Chondroitinase could be used for the treatment of spinal injuries . ref Cite news title Spinal injury regeneration hope. newspaper BBC NEWS, online year 2008 date Sunday, 17 February, 00 01 GMT url http news.bbc.co.uk 2 hi health 7240898.stm accessdate 2009 12 31 postscript Bot inserted parameter. Either remove it or change its value to . for the cite to end in a . , as necessary. inconsistent citations ref See also Neuroplasticity Interstitial fluid Proteoglycan Chondroitin sulfate References references Category Neurology procedures biochem stub ... more details
Infobox disease Name Spondyloepimetaphyseal dysplasia, Pakistani type Image Alt Caption DiseasesDB ICD10 ICD9 ICDO OMIM 612847 MedlinePlus eMedicineSubj eMedicineTopic MeshID Spondyloepimetaphyseal dysplasia, Pakistani type is a form of Spondyloepimetaphyseal dysplasia involving PAPSS2 also known as ATPSK2 . ref name pmid9771708 cite journal author Faiyaz ul Haque M, King LM, Krakow D, et al. title Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse journal Nat. Genet. volume 20 issue 2 pages 157 62 year 1998 month October pmid 9771708 doi 10.1038 2458 ref It was characterized in 1998. ref name pmid9714015 cite journal author Ahmad M, Haque MF, Ahmad W, et al. title Distinct, autosomal recessive form of spondyloepimetaphyseal dysplasia segregating in an inbred Pakistani kindred journal Am. J. Med. Genet. volume 78 issue 5 pages 468 73 year 1998 month August pmid 9714015 doi 10.1002 SICI 1096 8628 19980806 78 5 468 AID AJMG13 3.0.CO 2 D ref References reflist Proteoglycan disorders Category Proteoglycan metabolism disorders disease stub ... more details
protein Name glycosylation dependent cell adhesion molecule 1 caption image width HGNCid 18023 Symbol GLYCAM1 AltSymbols EntrezGene 644076 OMIM RefSeq XM 927461 UniProt Q8IVK1 PDB ECnumber Chromosome 12 Arm q Band 13.2 LocusSupplementaryData Glycosylation dependent cell adhesion molecule 1 GLYCAM1 is a proteoglycan ligand expressed on cells of the high endothelial venule s in lymph nodes. It is able to bind to the receptor L selectin during inflammation, acting as a homing beacon for leukocyte s expressing the receptor to enter the site of inflammation. ref name robspath cite book title Robbins Pathologic Basis of Disease last Cotran coauthors Kumar, Collins publisher W.B Saunders Company location Philadelphia id 0 7216 7335 X ref External links MeshName GlyCAM 1 References reflist biochem stub ... more details
protein Name leucine proline enriched proteoglycan leprecan 1 caption image width HGNCid 19316 Symbol LEPRE1 AltSymbols EntrezGene 64175 OMIM 610339 RefSeq NM 022356 UniProt Q32P28 PDB ECnumber Chromosome 1 Arm p Band 34.1 LocusSupplementaryData Leprecan is a protein associated with osteogenesis imperfecta ref name pmid18566967 cite journal author Cabral WA, Chang W, Barnes AM, et al title Prolyl 3 hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal severe osteogenesis imperfecta journal Nat. Genet. volume 39 issue 3 pages 359 65 year 2007 month March pmid 17277775 doi 10.1038 ng1968 ref type VIII. References reflist External links MeshName leprecan protein, human biochem stub Fibrous proteins ... more details
PBB geneid 60484 Hyaluronan and proteoglycan link protein 2 HAPLN2 also known as brain link protein 1 BRAL1 is a protein that in humans is encoded by the HAPLN2 gene . ref name entrez cite web title Entrez Gene hyaluronan and proteoglycan link protein 2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 60484 accessdate ref HAPLN1 codes for a related link protein that is expressed in cartilage while Bral1 is expressed in brain . Function Bral1 Protein protein interaction interact s with versican and brevican in nodes of Ranvier . In mice with reduced Bralp1 expression the extracellular matrix at nodes of Ranvier is disrupted and action potential conduction is abnormal. ref Cite pmid 20181608 ref References reflist Further reading refbegin 2 cite journal author Spicer AP, Joo A, Bowling RA title A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes the missing links. journal J. Biol. Chem. volume 278 issue 23 pages 21083 91 year 2003 pmid 12663660 doi 10.1074 jbc.M213100200 cite journal author K hler AK, Djurovic S, Rimol LM, et al. title Candidate gene analysis of the human natural killer 1 carbohydrate pathway and perineuronal nets in schizophrenia B3GAT2 is associated with disease risk and cortical surface area. journal Biol. Psychiatry volume 69 issue 1 pages 90 6 year 2011 pmid 20950796 doi 10.1016 j.biopsych.2010.07.035 cite journal author Nomoto H, Oohashi T, Hirakawa S, et al. title Human BRAL1 and BCAN genes that belong to the link module superfamily are tandemly arranged on chromosome 1q21 23. journal Acta Med. Okayama volume 56 issue 1 pages 25 9 year 2002 pmid 11873941 doi cite journal author Martins de Souza D, Gattaz WF, Schmitt A, et al. title Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia ... expression of the hyaluronan and proteoglycan link proteins in malignant gliomas. journal J. Biol. Chem ... more details
PBB geneid 10216 Proteoglycan 4 or lubricin is a protein that in humans is encoded by the PRG4 gene . ref name pmid10545950 cite journal author Marcelino J, Carpten JD, Suwairi WM, Gutierrez OM, Schwartz S, Robbins C, Sood R, Makalowska I, Baxevanis A, Johnstone B, Laxer RM, Zemel L, Kim CA, Herd JK, Ihle J, Williams C, Johnson M, Raman V, Alonso LG, Brunoni D, Gerstein A, Papadopoulos N, Bahabri SA, Trent JM, Warman ML title CACP, encoding a secreted proteoglycan, is mutated in camptodactyly arthropathy coxa vara pericarditis syndrome journal Nat Genet volume 23 issue 3 pages 319 22 year 1999 month Dec pmid 10545950 pmc doi 10.1038 15496 ref ref name pmid9920774 cite journal author Flannery CR, Hughes CE, Schumacher BL, Tudor D, Aydelotte MB, Kuettner KE, Caterson B title Articular cartilage ... proteoglycan with potential growth promoting, cytoprotective, and lubricating properties ... Gene PRG4 proteoglycan 4 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... journal author Schumacher BL, Block JA, Schmid TM, Aydelotte MB, Kuettner KE. title A novel proteoglycan ... issue 3 pages 594 600 pmid 10743795 ref Lubricin, MSF and SZP are now collectively known as Proteoglycan ... and expression of proteoglycan 4 cartilage superficial zone proteoglycan in tendon journal Matrix ... Proteoglycan 4 PRG4 synthesis and immunolocalization in bovine meniscus. journal J Orthop Res volume ... of the mouse and human PRG4 proteoglycan 4 genes. journal Cytogenet Cell Genet volume 90 issue ... author Marcelino J et al. year 1999 title CACP, encoding a secreted proteoglycan, is mutated in camptodactyly ..., et al. title A novel proteoglycan synthesized and secreted by chondrocytes of the superficial zone ... and mapping of the mouse and human PRG4 proteoglycan 4 genes. journal Cytogenet. Cell Genet. volume ... JR, Tudor D, et al. title Immunolocalisation and expression of proteoglycan 4 cartilage superficial zone proteoglycan in tendon. journal Matrix Biol. volume 21 issue 7 pages 593 602 year 2003 pmid ... more details
PBB geneid 633 Biglycan is a small leucine rich repeat proteoglycan SLRP which is found in a variety of extracellular matrix tissues, including bone , cartilage and tendon . In humans, biglycan is encoded by the BGN gene . ref name pmid1612609 cite journal author Traupe H, van den Ouweland AM, van Oost BA, Vogel W, Vetter U, Warren ST, Rocchi M, Darlison MG, Ropers HH title Fine mapping of the human biglycan BGN gene within the Xq28 region employing a hybrid cell panel journal Genomics volume 13 issue 2 pages 481 3 year 1992 month June pmid 1612609 doi 10.1016 0888 7543 92 90279 2 url issn ref Composition Biglycan consists of a protein core containing leucine rich repeat regions and two glycosaminoglycan GAG chains consisting of either chondroitin sulfate CS or dermatan sulfate DS , with DS being more abundant in most connective tissue s. The CS DS chains are attached at amino acids 5 and 10 in human biglycan. ref name pmid2590169 cite journal author Roughley PJ, White RJ title Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II journal The Biochemical Journal volume 262 issue 3 pages 823 7 year 1989 month September pmid 2590169 pmc 1133347 doi url issn ref The composition of the GAG chains has been reported as varying according to tissue of origin. Non glycanated forms of biglycan no GAG chains increase with age ... MC, Liu J, Pearce RH, Mort JS title Non proteoglycan forms of biglycan increase with age in human ... the proteoglycan contained two GAG chains formerly it was known as proteoglycan I PG I . ref ... of bone small proteoglycan I biglycan shows homology with proteoglycan II decorin and several nonconnective ..., Rosenberg LC, Choi HU, Timpl R, Hook M title Binding of the proteoglycan decorin to collagen type ... LW, Robey PG, Young MF title The small leucine rich proteoglycan biglycan modulates BMP 4 induced osteoblast ... cite journal author Bowe MA, Mendis DB, Fallon JR title The small leucine rich repeat proteoglycan ... more details
PBB geneid 176 Aggrecan also known as cartilage specific proteoglycan core protein CSPCP or chondroitin sulfate proteoglycan 1 is a protein that in humans is encoded by the ACAN gene . ref name pmid1985970 cite journal author Doege KJ, Sasaki M, Kimura T, Yamada Y title Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human specific repeats, and additional alternatively spliced forms journal J. Biol. Chem. volume 266 issue 2 pages 894 902 year 1991 month January pmid 1985970 doi ref This gene is a member of the chondroitin sulfate proteoglycan aggrecan versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage . Aggrecan is a proteoglycan , or a protein modified with large carbohydrate s the human form of the protein is 2316 amino acid s long and can be expressed in multiple isoform s due to alternative splicing . ref name pmid1985970 Structure Aggrecan is a high molecular weight 1x10 sup 6 sup M 3x10 sup 6 sup proteoglycan. It exhibits a bottlebrush structure, in which chondroitin sulfate and keratan sulfate chains are attached to an extended protein core. ref name pmid18689463 cite journal author Nap RJ, Szleifer ... folds and proteoglycan tandem repeats. Function Aggrecan is a critical component for cartilage ... of articular cartilage. Cartilage contains up to 10 proteoglycan consisting of mainly the large aggregating chondroitin sulfate proteoglycan aggrecan. Interactions Aggrecan has been shown to Protein protein ... sulfate proteoglycan, in cartilage structure and function. journal J. Biochem. volume 124 issue ... for the large cartilage specific proteoglycan. Evidence for alternative splicing of the domain. journal ... Kimata K, Barrach HJ, Brown KS, Pennypacker JP title Absence of proteoglycan core protein in cartilage ... R title Secreted chondroitin sulfate proteoglycan of human B cell lines binds to the complement protein ... more details
Infobox Disease Name Sclerocornea Image Caption DiseasesDB ICD10 ICD9 ICDO OMIM 269400 OMIM mult OMIM2 181700 MedlinePlus eMedicineSubj eMedicineTopic MeshID Sclerocornea is a congenital anomaly of the human eye eye in which the cornea blends with sclera , having no Corneal limbus clear cut boundary . The extent of the resulting opacity varies from peripheral to total sclerocornea totalis . The severe form is thought to be inherited in an autosomal recessive manner, but there may be another, milder form that is expressed in a dominant fashion. In some cases the patients also have abnormalities beyond the eye Systemic disease systemic , such as limb deformities and craniofacial and genitourinary defects. According to one tissue analysis performed after corneal transplantation , the sulfation pattern of keratan sulfate proteoglycan s in the affected area is typical for corneal rather than scleral tissue. ref name pmid16488970 cite journal author Young RD, Quantock AJ, Sotozono C, Koizumi N, Kinoshita S title Sulphation patterns of keratan sulphate proteoglycan in sclerocornea resemble cornea rather than sclera journal Br J Ophthalmol volume 90 issue 3 pages 391 3 year 2006 month March pmid 16488970 pmc 1856931 doi 10.1136 bjo.2005.085803 url http bjo.bmj.com cgi pmidlookup?view long&pmid 16488970 ref Sclerocornea may be concurrent with cornea plana . References reflist 2 External links http emedicine.medscape.com article 1197148 overview Congenital Clouding of the Cornea eMedicine by Noah S Scheinfeld, MD, JD, FAAD and Benjamin D Freilich, MD, FACS Congenital malformations and deformations of eye Category Diseases of the eye and adnexa ... more details
Enamel lamellae are a type of hypomineralized structure in teeth that extend either from the dentin dentinoenamel junction DEJ to the surface of the tooth enamel enamel , or vice versa. In essence, they are prominent linear enamel defects, but are of no clinical consequence. ref Histology Course Notes Mature Enamel , New Jersey Dental School, 2003 2004, page 2. ref These structures contain protein s, proteoglycan s, and lipids. Enamel lamellae should not be confused with two similar entities, enamel tufts and enamel spindles . Enamel tufts are small, branching defects that are found only at the DEJ, and so differ from lamellae which can be facing either direction and are strictly linear. Enamel spindles are also linear defects, but they too can be found only at the DEJ, because they are formed by entrapment of odontoblast processes between ameloblast s prior to and during amelogenesis . References references dentistry stub Category Dental enamel ... more details
PBB geneid 10675 Chondroitin sulfate proteoglycan 5 is a protein that in humans is encoded by the CSPG5 gene . ref name pmid9950058 cite journal author Yasuda Y, Tokita Y, Aono S, Matsui F, Ono T, Sonta S, Watanabe E, Nakanishi Y, Oohira A title Cloning and chromosomal mapping of the human gene of neuroglycan C NGC , a neural transmembrane chondroitin sulfate proteoglycan with an EGF module journal Neurosci Res volume 32 issue 4 pages 313 22 year 1999 month May pmid 9950058 pmc doi 10.1016 S0168 0102 98 00098 4 ref ref name entrez cite web title Entrez Gene CSPG5 chondroitin sulfate proteoglycan 5 neuroglycan C url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 10675 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions CSPG5 has been shown to Protein protein interaction interact with GOPC . ref name pmid12885772 cite journal last Hassel first Burkhard authorlink coauthors Schreff Matthias, Stube Eva Maria, Blaich Uta, Schumacher Stefan year 2003 month Oct. title CALEB NGC interacts with the Golgi associated protein PIST journal J. Biol. Chem. volume 278 issue 41 pages 40136 43 publisher location United States issn 0021 9258 pmid 12885772 doi 10.1074 jbc.M305577200 bibcode oclc id url language format accessdate laysummary laysource laydate quote ref References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Ichihara Tanaka K, Oohira A, Rumsby M, Muramatsu T title Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor like cells. journal J. Biol. Chem. volume 281 issue 41 pages 30857 64 year 2006 pmid 16901907 doi 10.1074 jbc.M602228200 cite journal author Aono S, Tokita Y, Yasuda Y, et al. title Expression and identification of a new splice variant of neuroglycan C, a transmembrane chondroitin sulfate proteoglycan, in the human ... more details
Multiple issues orphan July 2010 context 2010 NG2 glia is a type of macroglia found in the central nervous system , which is distinct from astrocytes and oligodendrocytes . ref cite journal last1 Raff first1 MC last2 Miller first2 RH last3 Noble first3 M year 1983 title A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium journal Nature volume 303 pages 390 396 doi 10.1038 303390a0 pmid 6304520 issue 5916 ref They get their name from the expression of NG2 proteoglycan on their surface. Although their exact function is unknown, they are found engulfing synapses and express receptors specific for the synapses. ref pmid 10088675 ref NG2 glia were believed to be the precursors of oligodendrocytes, but recent evidence suggests that they have distinct functions and divide very slowly. From an evolutionary point of view, the NG2 glia attained more complexity in the mammals and primates. References reflist DEFAULTSORT Ng2 Glia Category Glial cells it NG2 Glia ... more details
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