Chembox verifiedrevid 464376879 ImageFileL1 Ref chemboximage correct ?? ImageFileL1 Pyridazine numbering.png ImageSizeL1 75px ImageFileR1 Pyridazine3d.png ImageSizeR1 100px IUPACName Pyridazine OtherNames 1,2 diazine, orthodiazine, oizine Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 8902 InChI 1 C4H4N2 c1 2 4 6 5 3 1 h1 4H InChIKey PBMFSQRYOILNGV UHFFFAOYAA ChEMBL Ref ebicite correct EBI ChEMBL 15719 StdInChI Ref stdinchicite correct chemspider StdInChI 1S C4H4N2 c1 2 4 6 5 3 1 h1 4H StdInChIKey Ref stdinchicite correct chemspider StdInChIKey PBMFSQRYOILNGV UHFFFAOYSA N CASNo Ref cascite correct CAS CASNo 289 80 5 PubChem 9259 ChEBI Ref ebicite correct EBI ChEBI 30954 SMILES c1ccnnc1 RTECS GY2390000 Section2 Chembox Properties Formula C 4 H 4 N 2 MolarMass 80.09 g mol Appearance colorless liquid Density 1.107 g cm sup 3 sup MeltingPtC 8 BoilingPtC 208 Solubility pKa 2.10 ref Brown, H.C., et al., in Baude, E.A. and Nachod, F.C., Determination of Organic Structures by Physical Methods , Academic Press, New York, 1955. ref pKb Section3 Chembox Hazards MainHazards FlashPt Autoignition Section8 Chembox Related OtherCpds pyridine , pyrimidine , pyrazine Pyridazine is a heteroaromatic organic compound with the molecular formula C sub 4 sub H sub 4 sub N sub 2 sub , sometimes called 1,2 diazine . It contains a six membered ring with two adjacent nitrogen atoms. It is a colorless liquid with a boiling point of 208 C. Pyridazine has no household use. It is mainly used in research and industry as building block for more complex compounds. The pyridazine structure is found within a number of herbicides such as credazine , pyridafol and pyridate . It is also found within the structure of several pharmaceutical drugs such as cefozopran , cadralazine , minaprine , pipofezine , hydralazine , and cilazapril . References references Category Pyridazines de Pyridazin es Piridazina fr Pyridazine nl Pyridazine ja pt Piridazina sv Pyridazin ... more details
The molecular formula C sub 4 sub H sub 4 sub N sub 2 sub may refer to Pyrazine Pyridazine Pyrimidine Succinonitrile MolFormDisambig fr C4H4N2 ... more details
Distinguish Diazene Unreferenced date December 2009 Diazine refers to a group of organic compound s having the molecular formula C sub 4 sub H sub 4 sub N sub 2 sub . Each contains a benzene ring in which two of the C H fragments have been replaced by isolobal nitrogen. There are three isomer s pyrazine 1,4 diazine image pyrazine simple structure.svg pyrimidine 1,3 diazine image Pyrimidin.svg pyridazine 1,2 diazine image pyridazine simple structure.svg See also 6 membered rings with one nitrogen atom pyridine s 6 membered rings with three nitrogen atoms triazine s 6 membered rings with four nitrogen atoms tetrazine s 6 membered rings with six nitrogen atoms hexazine s Category Diazines de Diazine es Diazina fr Diazine it Diazine nl Diazine ja pt Diazina ru sv Diazin zh ... more details
chembox verifiedrevid 408212873 Reference ref Merck Index , 11th Edition, 7344 . ref ImageFile Phthalazin Phthalazine.svg ImageSize 180px IUPACName Phthalazine OtherNames Benzo orthodiazine br 2,3 Benzodiazine br Benzo d pyridazine Section1 Chembox Identifiers CASNo 253 52 1 PubChem 9207 SMILES C1 CC C2C NN CC2 C1 Section2 Chembox Properties C 8 H 6 N 2 Appearance Pale yellow needles Density MeltingPtCL 90 MeltingPtCH 91 BoilingPtCL 315 BoilingPtCH 317 Boiling notes decomposition Solubility Miscible pKa 3.39 ref Brown, H.C., et al., in Baude, E.A. and Nachod, F.C., Determination of Organic Structures by Physical Methods , Academic Press, New York, 1955. ref Section3 Chembox Hazards MainHazards FlashPt Autoignition Phthalazine , also called benzo orthodiazine or benzopyridazine, is a heterocyclic organic compound with the molecular formula C sub 8 sub H sub 6 sub N sub 2 sub . It is isomer ic with quinoxaline , cinnoline and quinazoline . Synthesis Phthalazine can be obtained by the condensation reaction condensation of w tetrabromorthoxylene with hydrazine , or by the Redox reduction of chlorphthalazine with phosphorus and hydroiodic acid . Properties It possesses base chemistry basic properties and forms addition products with alkyl iodide s. Reactions Upon oxidation with alkaline potassium permanganate it yields pyridazine dicarboxylic acid . Zinc and hydrochloric acid decompose it with formation of orthoxylylene diamine. The keto hydro derivative phthalazone C sub 8 sub H sub 6 sub ON sub 2 sub , is obtained by condensing hydrazine with orthophthalaldehydoacid Citation needed date July 2011 . On treatment with phosphorus oxychloride , it yields a chlorphthalazine, which with zinc and hydrochloric acid gives isoindole C sub 8 sub H sub 7 sub N , and with tin and hydrochloric acid, phthalimidine C sub 8 sub H sub 7 sub ON , the second nitrogen atom being eliminated as ammonia . References reflist 1911 Category Phthalazines ... more details
Drugbox verifiedrevid 448020282 IUPAC name 3 methyl 6 3 trifluoromethyl phenyl 1,2,4 triazolo 3,4 f pyridazine image CL 218,872.svg width 140 Clinical data tradename pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU Unscheduled S2 S3 S4 S5 S6 S7 S8 S9 legal CA Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL P POM CD Class A, B, C legal US OTC Rx only Schedule I, II, III, IV, V legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers CAS number 66548 69 4 ATC prefix ATC suffix ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 97072 StdInChI Ref stdinchicite correct chemspider StdInChI 1S C13H9F3N4 c1 8 17 18 12 6 5 11 19 20 8 12 9 3 2 4 10 7 9 13 14,15 16 h2 7H,1H3 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey GUOQUXNJZHGPQF UHFFFAOYSA N ChEMBL 13662 PubChem 107950 DrugBank Ref drugbankcite correct drugbank DrugBank Chemical data C 13 H 9 F 3 N 4 molecular weight 278.233 g mol CL 218,872 is a sedative and hypnotic drug used in scientific research. ref Moreau S, Coudert P, Rubat C, Gardette D, Vallee Goyet D, Couquelet J, Bastide P, Tronche P. Synthesis and anticonvulsant properties of new benzylpyridazine derivatives. Journal of Medicinal Chemistry . 1994 Jul 8 37 14 2153 60. ref ref Karolak Wojciechowska J, Lange J, Kwiatkowski W, Gniewosz M, Plenkiewicz J. Bicyclic b heteroannulated pyridazine derivatives II. Structure activity relationships in the 6 aryltriazolo 4,3 b pyridazine ligands of the benzodiazepine receptor. Bioorganic and Medicinal Chemistry . 1994 Aug 2 8 773 9. ref It has similar effects to sedative hypnotic benzodiazepine drugs such as triazolam , but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic. CL 218,872 is a GABA A receptor GABA sub A sub partial agonist which is selective for the 1 subtype. ref Hadingham KL, Wafford KA, Thompson SA, Palmer KJ, Whiting PJ. Expression ... more details
Unreferenced date December 2009 Orphan date December 2009 border 0 cellpadding 5 cellspacing 0 style margin 1em float right class wikitable colspan 3 Basic aromatic ring systems align center valign bottom Image Pyridine structure.png 67px br Pyridine Image Quinoline structure.png 119px br Quinoline Image Isoquinoline structure.png 126px br Isoquinoline align center valign bottom Image Acridine structure.png 171px br Acridine align center valign bottom Image Pyrazine structure.png 67px br Pyrazine Image Quinoxaline structure.png 119px br Quinoxaline align center valign bottom Image Imidazole structure.png 63px br Imidazole Image Benzimidazole structure.png 113px br Benzimidazole Image Purine structure.png 113px br Purine align center valign bottom Image Pyrazole structure.png 70px br Pyrazole Image Indazole structure.png 120px br Indazole align center valign bottom Image Pyrimidine structure.png 74px br Pyrimidine Image Quinazoline structure.png 126px br Quinazoline align center valign bottom Image Pyridazine structure.png 74px br Pyridazine Image Cinnoline structure.png 126px br Cinnoline Basic aromatic rings are simple aromatic ring aromatic rings in which the lone pair of electron s of a ring nitrogen atom is not part of the aromatic system and extends in the plane of the ring. This lone pair is responsible for the Base chemistry basicity of these nitrogenous base s, similar to the nitrogen atom in amine s. In these compounds the nitrogen atom is not connected to a hydrogen atom. Basic aromatic compounds get Protonation protonated and form aromatic cation s e.g. pyridinium under acid ic conditions. Typical examples of basic aromatic rings are pyridine or quinoline . Several rings contain basic as well as non basic nitrogen atoms, e.g. imidazole and purine . In non basic aromatic rings the lone pair of electron s of the nitrogen atom is delocalized and contributes to the aromatic pi electron system. In these compounds the nitrogen atom is connected to a hydrogen at ... more details
distinguish Tetrazene Image 1,2,3,4 tetrazine numbering.png thumb right 100px Structure of 1,2,3,4 tetrazine Image 1,2,4,5 tetrazine numbering.png thumb right 100px Structure of 1,2,4,5 tetrazine Tetrazine is an unstable Chemical compound compound that consists of a six membered aromatic ring containing four nitrogen atoms with the molecular formula Carbon C sub 2 sub Hydrogen H sub 2 sub Nitrogen N sub 4 sub . The name tetrazine is used in the IUPAC nomenclature nomenclature of derivatives of this compound. Three core ring isomer s exist 1,2,3,4 tetrazines , 1,2,3,5 tetrazines and 1,2,4,5 tetrazines . 1,2,3,4 tetrazines 1,2,3,4 Tetrazines are often isolated fused to an aromatic ring system and are stabilized as the dioxide derivatives. 1,2,4,5 tetrazine 1,2,4,5 Tetrazines are very well known and myriad 3,6 disubstituted 1,2,4,5 tetrazines are known. ref see United States Patent 6645325 ref These materials are of use in the area of energetic chemistry. The compound 3,6 di 2 pyridyl 1,2,4,5 tetrazine ref Datasheet http www.sigmaaldrich.com catalog search ProductDetail ALDRICH 403547 Link ref has two pyridine substituents and is of importance as a reagent in Diels Alder reaction s. It reacts with norbornadiene in a sequence of one DA reactions and two retro DA reactions to cyclopentadiene and a pyridazine with exchange of an acetylene unit Image DielsAlderCycloadditionDTP.png 500px reaction of norbornadiene with 3,6 di 2 pyridyl 1,2,4,5 tetrazine With norbornadiene fused to an arene the reaction stops at an intermediary stage ref Bond Screening in Benzonorbornadienes The Role of 7 Substituents in Governing the Facial Selectivity for the Diels Alder Reaction of Benzonorbornadienes with 3,6 Di 2 pyridyl s Tetrazine . Ronald N. Warrener and Peter A. Harrison Molecules journal Molecules 2001 , 6, 353 369 http www.mdpi.org molecules papers 60400353.pdf Online Article ref See also 6 membered rings with one nitrogen atom pyridine s 6 membered rings with two nitrogen atoms ... more details
Drugbox Verifiedfields changed Watchedfields changed verifiedrevid 444260282 IUPAC name 6 benzoyl 3 hydrazinyl 5 H ,6 H ,7 H ,8 H pyrido 4,3 c pyridazine image Endralazine.png Clinical data tradename pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled legal CA Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL, P, POM, CD, or Class A, B, C legal US OTC Rx only Schedule I, II, III, IV, V legal status routes of administration Pharmacokinetic data protein bound metabolism elimination half life excretion Identifiers CAS number Ref cascite correct ?? CAS number 39715 02 1 ATC prefix C02 ATC suffix DB03 PubChem 47608 DrugBank Ref drugbankcite correct drugbank DrugBank UNII Ref fdacite correct FDA UNII L44741F05P KEGG Ref keggcite correct kegg KEGG D08254 ChEMBL Ref ebicite changed EBI ChEMBL 254193 Chemical data chemical formula C 14 H 15 N 5 O 1 molecular weight 269.30 g mol Endralazine is an antihypertensive of the hydrazine chemical class . See also Cadralazine Dihydralazine Hydralazine Nonsympatholytic vasodilatory antihypertensives Hydrazines Category Hydrazines Category Antihypertensive agents Category Amides Category Pyridazines antihypertensive stub es Endralazina ... more details
Drugbox verifiedrevid 464200031 IUPAC name 1,2 dihydro 1,5 dimethyl 2 phenyl 3 H pyrazol 3 one image Phenazone.svg width 200 drug name Antipyrine Clinical data tradename pregnancy category legal status routes of administration Pharmacokinetic data bioavailability metabolism excretion Identifiers CASNo Ref cascite correct CAS CAS number Ref cascite correct ?? CAS number 60 80 0 ATC prefix N02 ATC suffix BB01 ATC supplemental ATC S02 DA03 PubChem 2206 DrugBank Ref drugbankcite correct drugbank DrugBank DB01435 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 2121 UNII Ref fdacite correct FDA UNII T3CHA1B51H KEGG Ref keggcite correct kegg KEGG D01776 ChEBI Ref ebicite correct EBI ChEBI 31225 ChEMBL Ref ebicite correct EBI ChEMBL 277474 Chemical data C 11 H 12 N 2 O 1 molecular weight 188.226 g mol smiles O C2 C C N N2c1ccccc1 C C InChI 1 C11H12N2O c1 9 8 11 14 13 12 9 2 10 6 4 3 5 7 10 h3 8H,1 2H3 InChIKey VEQOALNAAJBPNY UHFFFAOYAS StdInChI Ref stdinchicite correct chemspider StdInChI 1S C11H12N2O c1 9 8 11 14 13 12 9 2 10 6 4 3 5 7 10 h3 8H,1 2H3 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey VEQOALNAAJBPNY UHFFFAOYSA N synonyms analgesine, antipyrine Phenazone International Nonproprietary Name INN , phenazon , antipyrine United States Adopted Name USAN , or analgesine is an analgesic and antipyretic . It was first synthesized by Ludwig Knorr in 1883. ref Cite journal doi 10.1016 S1366 0071 97 80033 2 title The early history of non opioid analgesics year 1997 last1 Brune first1 K journal Acute Pain volume 1 pages 33 ref It is formed by reducing diortho dinitrodiphenyl with sodium amalgam and methyl alcohol , or by heating diphenylene ortho dihydrazine with hydrochloric acid to 150 C. It crystal lizes in needles which melt at 156 C. Potassium permanganate oxidize s it to pyridazine tetracarboxylic acid. Phenazone has an elimination half life of about 12 hours. ref http www.mims.com USA drug info phenazone ?q Other 20Ear 20Preparati ... more details
Drugbox verifiedrevid 376274723 IUPAC name 7 Cyclobutyl 6 2 ethyl 2H 1,2,4 triazol 3 ylmethoxy 3 phenyl 1,2,4 triazolo 4,3 b pyridazine image TP 13.png Clinical data tradename pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU Unscheduled S2 S3 S4 S5 S6 S7 S8 S9 legal CA Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL P POM CD Class A, B, C legal US OTC Rx only Schedule I, II, III, IV, V legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism excretion Identifiers CAS number ATC prefix ATC suffix PubChem DrugBank Chemical data C 19 H 19 N 7 O 1 molecular weight 361.400 g mol smiles C5CCC5c3cc2nnc c4ccccc4 n2nc3OCc1ncnn1C TP 13 is an anxiolytic drug with a novel chemical structure, which is used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. It is a subtype selective partial agonist at GABA A receptor GABA sub A sub receptor s, binding selectively to GABA sub A sub receptor complexes bearing 2 and 3 subunits. ref McCabe C, Shaw D, Atack JR, Street LJ, Wafford KA, Dawson GR, Reynolds DS, Leslie JC. Subtype selective GABAergic drugs facilitate extinction of mouse operant behaviour. Neuropharmacology . 2004 Feb 46 2 171 8. PMID 14680756 ref It has modest anticonvulsant activity although less than that of diazepam , ref Fradley RL, Guscott MR, Bull S, Hallett DJ, Goodacre SC, Wafford KA, Garrett EM, Newman RJ, O Meara GF, Whiting PJ, Rosahl TW, Dawson GR, Reynolds DS, Atack JR. Differential contribution of GABA A receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands. Journal of Psychopharmacology . 2007 Jun 21 4 384 91. PMID 17092983 ref and its main effect is likely to be selective anxiolytic action, as seen with other related 2 3 preferring agonists such as L 838,417 . References references Anxiolytics Category Anxiolytics Category Ethers Category Triazole ... more details
Drugbox Verifiedfields changed verifiedrevid 477370741 IUPAC name 3 2 morpholin 4 yl ethyl amino 6 phenylpyridazine 4 carbonitrile image Bazinaprine.svg CAS number Ref cascite changed ?? CAS number 94011 82 2 ATC prefix None ATC suffix UNII Ref fdacite correct FDA UNII NU8Y4C529J ChEMBL Ref ebicite correct EBI ChEMBL 150365 PubChem 72119 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 65096 C 17 H 19 N 5 O 1 molecular weight 309.366 g mol smiles N Cc2cc nnc2NCCN1CCOCC1 c3ccccc3 InChI 1 C17H19N5O c18 13 15 12 16 14 4 2 1 3 5 14 20 21 17 15 19 6 7 22 8 10 23 11 9 22 h1 5,12H,6 11H2, H,19,21 InChIKey KRNDIPHOJLIHRI UHFFFAOYAK StdInChI Ref stdinchicite correct chemspider StdInChI 1S C17H19N5O c18 13 15 12 16 14 4 2 1 3 5 14 20 21 17 15 19 6 7 22 8 10 23 11 9 22 h1 5,12H,6 11H2, H,19,21 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey KRNDIPHOJLIHRI UHFFFAOYSA N bioavailability protein bound metabolism elimination half life excretion pregnancy category legal status routes of administration Bazinaprine SR 95,191 is an experimental drug candidate. It is a monoamine oxidase inhibitor MAOI which is believed to be useful for the treatment of depression mood depression . The drug strongly inhibits type A monoamine oxidase , but only weakly inhibits type B. The effects of the drug are reversible in vivo , but not in vitro . ref name 88newderivative cite journal pmid 3346672 year 1988 last1 Kan first1 JP last2 Steinberg first2 R last3 Leclercq first3 J last4 Worms first4 P last5 Biziere first5 K title Monoamine oxidase inhibiting properties of SR 95191, a new pyridazine derivative, in the rat Evidence for selective and reversible inhibition of monoamine oxidase type a in vivo but not in vitro volume 50 issue 4 pages 1137 44 journal Journal of neurochemistry ref In studies, the chemical has been shown to not interact in vivo with other neurotransmitter or drug receptor sites. ref name 87MAOI cite journal pmid 3100771 year 1987 last1 Kan first1 JP last2 ... more details
Chembox Verifiedfields changed Watchedfields changed verifiedrevid 414056174 ImageFile Hexazine.svg ImageFile Ref chemboximage correct ?? ImageSize 244 ImageName Kekul and aromatic, skeletal formulae of hexazine ImageFile2 Hexazine3.png ImageFile2 Ref chemboximage correct ?? ImageSize2 244 ImageName2 Ball and stick, and spacefill models of hexazine SystematicName Hexazine ref Cite web url http pubchem.ncbi.nlm.nih.gov summary summary.cgi?cid 11966278&loc ec rcs title Hexazine PubChem Public Chemical Database work The PubChem Project location USA publisher National Center for Biotechnology Information ref OtherNames Hexaazabenzene Section1 Chembox Identifiers CASNo Ref cascite changed ?? CASNo 7616 35 5 PubChem 11966278 PubChem Ref PubChem correct pubchem ChemSpiderID 10140271 ChemSpiderID Ref chemspidercite changed chemspider ChEBI Ref ebicite changed EBI ChEBI 36869 Gmelin 1819 SMILES n1nnnnn1 SMILES1 N1 NN NN N1 StdInChI 1S N6 c1 2 4 6 5 3 1 StdInChI Ref stdinchicite changed chemspider StdInChIKey YRBKSJIXFZPPGF UHFFFAOYSA N StdInChIKey Ref stdinchicite changed chemspider Section2 Chembox Properties N 6 ExactMass 84.018444030 g mol sup 1 sup Hexazine also known as hexaazabenzene is a hypothetical allotrope of nitrogen composed of 6 nitrogen atoms arranged in a ring like structure analogous to that of benzene . It would be the final member of the azabenzene azine series, having all of the methylidyne groups of the benzene molecule replaced with nitrogen atoms. The two last members of this series, hexazine and pentazine, have not been observed, although all other members of the azine series have such as pyridine , pyrimidine , pyridazine , pyrazine , 1,3,5 triazine and tetrazine . Stability The hexazine molecule bears a structural similarity to the very stable benzene molecule. Like benzene, it has been calculated that hexazine is likely an aromatic molecule. Despite this, it has yet to be synthesized. In fact, it has been predicted computationally that the hexazin ... more details
Drugbox Watchedfields changed verifiedrevid 402884937 IUPAC name 2 4 Chlorophenyl 5,6 dihydro 1 benzothepino 5,4 c pyridazin 3 2H one 7 oxide image Y 23684 2d skeletal.png Clinical data tradename pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU Unscheduled S2 S3 S4 S5 S6 S7 S8 S9 legal CA Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL P POM CD Class A, B, C legal US OTC Rx only Schedule I, II, III, IV, V legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers CAS number 118288 67 8 ATC prefix ATC suffix PubChem 195253 DrugBank Ref drugbankcite correct drugbank DrugBank ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 169332 Chemical data C 18 H 13 Cl 1 N 2 O 2 S 1 molecular weight 356.826 g mol smiles Clc4ccc N1 N C2 C C C1 O CCS O c3ccccc23 cc4 StdInChI Ref stdinchicite correct chemspider StdInChI 1S C18H13ClN2O2S c19 13 5 7 14 8 6 13 21 17 22 11 12 9 10 24 23 16 4 2 1 3 15 16 18 12 20 21 h1 8,11H,9 10H2 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey WHMCSFWQVGJBGM UHFFFAOYSA N Y 23684 is an anxiolytic drug with a novel chemical structure, which is used in scientific research. ref Nakao T, Obata M, Kawakami M, Morita K, Tanaka H, Morimoto Y, Takehara S, Yakushiji T, Tahara T. Studies on the synthesis of condensed pyridazine derivatives. IV. Synthesis and anxiolytic activity of 2 aryl 5,6 dihydro 1 benzothiepino 5,4 c pyridazin 3 2H ones and related compound. Chemical and Pharmaceutical Bulletin Tokyo . 1991 Oct 39 10 2556 63. ref ref Nakao T, Obata M, Yamaguchi Y, Marubayashi N, Ikeda K, Morimoto Y. Synthesis and biological activities of optical isomers of 2 4 chlorophenyl 5,6 dihydro 1 benzothiepino 5,4 c pyridazin 3 2H one 7 oxide. Chemical and Pharmaceutical Bulletin Tokyo . 1992 Jan 40 1 117 21. ref It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodi ... more details
Chembox verifiedrevid 464377262 ImageFile1 Ref chemboximage correct ?? ImageFile1 Pyrimidine chemical structure.png ImageSize1 280px ImageFile2 Pyrimidine2.png ImageSize2 190px IUPACName Pyrimidine OtherNames 1,3 Diazine, m Diazine Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 8903 KEGG Ref keggcite correct kegg KEGG C00396 InChI 1 C4H4N2 c1 2 5 4 6 3 1 h1 4H InChIKey CZPWVGJYEJSRLH UHFFFAOYAT ChEMBL Ref ebicite correct EBI ChEMBL 15562 StdInChI Ref stdinchicite correct chemspider StdInChI 1S C4H4N2 c1 2 5 4 6 3 1 h1 4H StdInChIKey Ref stdinchicite correct chemspider StdInChIKey CZPWVGJYEJSRLH UHFFFAOYSA N CASNo Ref cascite correct CAS CASNo 289 95 2 PubChem 9260 ChEBI Ref ebicite correct EBI ChEBI 16898 SMILES c1cncnc1 MeSHName pyrimidine Section2 Chembox Properties Formula C sub 4 sub H sub 4 sub N sub 2 sub MolarMass 80.088 g mol sup 1 sup Appearance Density 1.016 g cm sup 3 sup MeltingPtCL 20 MeltingPtCH 22 BoilingPtCL 123 BoilingPtCH 124 Solubility pKa 1.10 ref Brown, H.C., et al., in Baude, E.A. and Nachod, F.C., Determination of Organic Structures by Physical Methods , Academic Press, New York, 1955. ref protonated pyrimidine Section3 Chembox Hazards MainHazards FlashPt Autoignition Pyrimidine is a heterocyclic aromatic organic compound similar to benzene and pyridine , containing two nitrogen atoms at positions 1 and 3 of the six member ring. ref name isbn0 582 27843 0 cite book author Gilchrist, Thomas Lonsdale Gilchrist, T. L. authorlink editor others title Heterocyclic chemistry edition language publisher Longman location New York year 1997 origyear pages quote isbn 0 582 27843 0 oclc doi url accessdate ref It is isomer ic with two other forms of diazine Pyridazine , with the nitrogen atoms in positions 1 and 2 and Pyrazine , with the nitrogen atoms in positions 1 and 4. Chemical properties A pyrimidine has many properties in common with pyridine , as the number of nitrogen atoms in the ring increases the rin ... more details
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