Section3 Chembox Hazards MainHazards FlashPt Autoignition Pyridoxamine is a vitamer in the vitamin B6 vitamin B sub 6 sub family, which includes pyridoxal and pyridoxine . Pyridoxamine is converted ... of metabolic processes. In food, pyridoxamine is commonly found as a 5 phosphate derivative, which is hydrolyzed by intestinal phosphatase s to pyridoxamine and absorbed in the jejunum . ref cite ... ref Absorbed pyridoxamine is converted to pyridoxamine 5 phosphate by pyridoxal kinase , which is further converted to the active pyridoxal 5 phosphate by pyridoxamine phosphate transaminase ... pmid 6380540 doi 10.1146 annurev.nu.04.070184.002323 ref Pyridoxamine is based on a pyridine ring ... 4 of its ring endow pyridoxamine with a variety of chemical properties, including the Scavenger ... Adrover et al cite journal author Adrover M, Vilanova B, Frau J, Mu oz F, Donoso J title The pyridoxamine ... j.bmc.2008.04.002 url ref Research Pyridoxamine can form fairly weak complexes with a number of transition ... & Hudson cite journal author Voziyan PA, Hudson BG title Pyridoxamine as a multifunctional pharmaceutical ... of pyridoxamine allows for efficient hydroxyl radical scavenging. ref name Voziyan & Hudson Pyridoxamine ... name pmid16037308 cite journal author Voziyan PA, Hudson BG title Pyridoxamine the many virtues ... volume 9 issue 3 pages 233 45 year 2007 pmid 17391149 doi 10.1111 j.1463 1326.2006.00595.x url ref Pyridoxamine ... reaction . ref name Giannoukakis One research study found that pyridoxamine specifically reacts ... to advanced glycation endproducts is due in much greater part to the metal chelation effects of pyridoxamine ... that pyridoxamine improved kidney histology comparable or superior to aminoguanidine . ref name Giannoukakis Because of these results, pyridoxamine has been investigated for clinical utility in the treatment ... Pyridoxamine BioStratum journal Curr Opin Investig Drugs volume 6 issue 4 pages 410 8 year 2005 pmid ... Effects of pyridoxamine in combined phase 2 studies of patients with type 1 and type 2 diabetes ... more details
enzyme Name pyridoxamine phosphate transaminase EC number 2.6.1.54 CAS number 9074 84 4 IUBMB EC number 2 6 1 54 GO code 0019163 image width caption In enzymology , a pyridoxamine phosphate transaminase EC number 2.6.1.54 is an enzyme that catalysis catalyzes the chemical reaction pyridoxamine 5 phosphate 2 oxoglutarate math rightleftharpoons math pyridoxal 5 phosphate D glutamate Thus, the two substrate biochemistry substrates of this enzyme are pyridoxamine 5 phosphate and 2 oxoglutarate , whereas its two product chemistry products are pyridoxal 5 phosphate and D glutamate . This enzyme belongs to the family of transferase s, specifically the transaminases , which transfer nitrogenous groups. The systematic name of this enzyme class is pyridoxamine 5 phosphate 2 oxoglutarate aminotransferase D glutamate forming . Other names in common use include pyridoxamine phosphate aminotransferase , pyridoxamine 5 phosphate alpha ketoglutarate transaminase , and pyridoxamine 5 phosphate transaminase . This enzyme participates in vitamin B6 vitamin B sub 6 sub metabolism . References reflist 1 cite journal author Tani Y, Ukita M and Ogata K date 1972 title Studies on vitamin B6 metabolism in microorganisms. Part X. Further purification and characterization of pyridoxamine 5 phosphate alpha ketoglutarate transaminase from Clostridium kainantoi journal Agric. Biol. Chem. volume 36 pages 181&ndash 188 transferase stub Category EC 2.6.1 Category Enzymes of unknown structure ... more details
enzyme Name pyridoxamine pyruvate transaminase EC number 2.6.1.30 CAS number 9023 38 5 IUBMB EC number 2 6 1 30 GO code 0047300 image width caption In enzymology , a pyridoxamine pyruvate transaminase EC number 2.6.1.30 is an enzyme that catalysis catalyzes the chemical reaction pyridoxamine pyruvate math rightleftharpoons math pyridoxal L alanine Thus, the two substrate biochemistry substrates of this enzyme are pyridoxamine and pyruvate , whereas its two product chemistry products are pyridoxal and L alanine . This enzyme belongs to the family of transferase s, specifically the transaminases , which transfer nitrogenous groups. The systematic name of this enzyme class is pyridoxamine pyruvate aminotransferase . This enzyme is also called pyridoxamine pyruvic transaminase . This enzyme participates in vitamin B6 vitamin B sub 6 sub metabolism . References reflist 1 cite journal author Wada H and Snell EE date 1962 title Enzymatic transamination of pyridoxamine. II. Crystalline pyridoxamine pyruvate transaminase journal J. Biol. Chem. volume 237 pages 133&ndash 137 pmid 14004227 transferase stub Category EC 2.6.1 Category Enzymes of unknown structure ... more details
enzyme Name pyridoxamine oxaloacetate transaminase EC number 2.6.1.31 CAS number 37277 88 6 IUBMB EC number 2 6 1 31 GO code 0019162 image width caption In enzymology , a pyridoxamine oxaloacetate transaminase EC number 2.6.1.31 is an enzyme that catalysis catalyzes the chemical reaction pyridoxamine oxaloacetate math rightleftharpoons math pyridoxal L aspartate Thus, the two substrate biochemistry substrates of this enzyme are pyridoxamine and oxaloacetate , whereas its two product chemistry products are pyridoxal and L aspartate . This enzyme belongs to the family of transferase s, specifically the transaminases , which transfer nitrogenous groups. The systematic name of this enzyme class is pyridoxamine oxaloacetate aminotransferase . This enzyme participates in vitamin B6 vitamin B sub 6 sub metabolism . References reflist 1 cite journal author Wada H and Snell EE date 1962 title Enzymatic transamination of pyridoxamine. I. With oxaloacetate and alpha ketoglutarate journal J. Biol. Chem. volume 237 pages 127&ndash 132 pmid 14004226 cite journal author Wu, HLC and Mason M date 1964 title Pyridoxamine oxaloacetic transaminase of rat kidney journal J. Biol. Chem. volume 239 pages 1492&ndash 1497 pmid 14189882 transferase stub Category EC 2.6.1 Category Enzymes of unknown structure ... more details
the presence of a cofactor, FMN flavin mononucleotide . ref name omim OMIM 603287 PYRIDOXAMINE ... several reactions the two most important are the deamination of pyridoxamine 5 phosphate and the deamination ...?map00750 1.4.3.5 Pyridoxine 5 phosphate oxidase s EC number is 1.4.3.5. ref name omim pyridoxamine ... Image Pyridoxamine reaction.gif pyridoxine phosphate oxygen H sub 2 sub O sub 2 sub pyridoxal phosphate ... for both pyridoxine 5 phosphate and pyridoxamine 5 phosphate. The enzyme also has a low turnover rate ... for the pyridoxamine 5 phosphate substrate, whereas the pyridoxine 5 phosphate oxidase in E. coli ... more details
Image Aspartate transaminase.png thumb right 300px Aspartate transaminase from E. coli with Pyridoxal 5 Phosphate cofactor In biochemistry , a transaminase or an aminotransferase is an enzyme that catalyze s a type of reaction between an amino acid and an alpha keto acid &alpha keto acid . To be specific, this reaction transamination involves removing the amino group from the amino acid, leaving behind an keto acid, and transferring it to the reactant keto acid and converting it into an amino acid. Some transamination activities of the ribosome have been found to be catalyzed by so called ribozymes RNA enzymes . Examples being the hammerhead ribozyme , the VS ribozyme and the hairpin ribozyme . The transaminase enzymes are important in the production of various amino acids, and measuring the concentration s of various transaminases in the blood is important in the diagnosing and tracking many disease s. Transaminases require the coenzyme pyridoxal phosphate , which is converted into pyridoxamine in the first phase of the reaction, when an amino acid is converted into a keto acid. Enzyme bound pyridoxamine in turn reacts with pyruvate , oxaloacetate , or alpha ketoglutarate , giving alanine , aspartic acid , or glutamic acid , respectively. Many transamination reactions occur in tissues, catalysed by transaminases specific for a particular amino keto acid pair. The reactions are readily reversible, the direction being determined by which of the reactants are in excess. The specific enzymes are named from one of the reactant pairs, for example the reaction between glutamic acid and pyruvic acid to make alpha ketoglutaric acid and alanine is called glutamic pyruvic transaminase or GPT for short. Tissue transaminase activities can be investigated by incubating a homogenate with various amino keto aci dpairs. Transamination is demonstrated if the corresponding new amino acid and keto acid are formed, as revealed by paper chromatography. Reversibility is demonstrated ... more details
chembox UNII Ref fdacite correct FDA UNII KV2JZ1BI6Z verifiedrevid 464377153 Reference ref http www.sigmaaldrich.com catalog search ProductDetail SIGMA P5669 Pyridoxine at Sigma Aldrich ref Name Pyridoxine ImageFile Ref chemboximage correct ?? ImageFile Pyridoxine structure ver2.svg ImageSize 180px ImageName Pyridoxine IUPACName 4,5 Bis hydroxymethyl 2 methylpyridin 3 ol Section1 Chembox Identifiers CASNo 65 23 6 CASNo Ref cascite correct CAS CASOther br CAS 58 56 0 hydrochloride HCl Also CAS verified PubChem 1054 KEGG Ref keggcite correct kegg KEGG D08454 ChEMBL Ref ebicite correct EBI ChEMBL 1364 DrugBank Ref drugbankcite correct drugbank DrugBank DB00165 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 1025 ChEBI Ref ebicite correct EBI ChEBI 16709 StdInChI Ref stdinchicite correct chemspider StdInChI 1S C8H11NO3 c1 5 8 12 7 4 11 6 3 10 2 9 5 h2,10 12H,3 4H2,1H3 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey LXNHXLLTXMVWPM UHFFFAOYSA N SMILES CC1 NC C C C1O CO CO ATCCode prefix A11 ATCCode suffix HA02 Section2 Chembox Properties C 8 H 11 N 1 O 3 Density MeltingPt 159 162 C BoilingPt Pyridoxine is one of the compounds that can be called vitamin B6 vitamin B sub 6 sub , along with pyridoxal and pyridoxamine . It differs from pyridoxamine by the substituent at the 4 position. It is often used as pyridoxine hydrochloride . Chemistry It is based on a pyridine ring, with hydroxyl , methyl , and hydroxymethyl substituent s. It is converted to the biologically active form pyridoxal 5 phosphate . Function in the body Pyridoxine assists in the balancing of sodium and potassium as well as promoting red blood cell production. It is linked to cardiovascular health by decreasing the formation of homocysteine . Pyridoxine may help balance hormonal changes in women and aid the immune system. ref cite journal doi 10.1016 j.ijgo.2006.09.014 title Pyridoxine vitamin B6 therapy for premenstrual syndrome year 2007 last1 Kashanian first1 M. last2 Mazinani f ... more details
forms of vitamin B sub 6 sub , pyridoxal and pyridoxamine. Vitamin B sub 6 sub was named pyridoxine ... Pyridoxamine PM Pyridoxamine 5 phosphate PMP 4 Pyridoxic acid PA , the Catabolism catabolite which ... form is converted from the other natural forms founds in food pyridoxal, pyridoxine and pyridoxamine ... processing, as they contain mostly pyridoxine, which is far more stable than the pyridoxal or pyridoxamine ... than what is needed for physiological demands. The absorption of pyridoxal phosphate and pyridoxamine ... kinase in the jejunal mucosa. The trapped pyridoxine and pyridoxamine are oxidized to pyridoxal ... have been given include pyridoxal, pyridoxamine, and pyridoxine and their phosphates. A small ... ref Though the mechanism is not known, results show pyridoxamine has therapeutic effects in clinical ... Pyridoxamine protects proteins from functional damage by 3 Deoxyglucosone mechanism of action of pyridoxamine ... more details
chembox verifiedrevid 464377081 Name Pyridoxal ImageFile Ref chemboximage correct ?? ImageFile Pyridoxal.png ImageSize 185px ImageName Skeletal formula of pyridoxal ImageFile1 Pyridoxal 3D balls.png ImageName1 Ball and stick model of pyridoxal IUPACName 3 hydroxy 5 hydroxymethyl 2 methylpyridine 4 carbaldehyde Section1 Chembox Identifiers UNII Ref fdacite correct FDA UNII 3THM379K8A ChEMBL Ref ebicite correct EBI ChEMBL 102970 KEGG Ref keggcite correct kegg KEGG C00250 InChI 1 C8H9NO3 c1 5 8 12 7 4 11 6 3 10 2 9 5 h2,4,10,12H,3H2,1H3 InChIKey RADKZDMFGJYCBB UHFFFAOYAP StdInChI Ref stdinchicite correct chemspider StdInChI 1S C8H9NO3 c1 5 8 12 7 4 11 6 3 10 2 9 5 h2,4,10,12H,3H2,1H3 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey RADKZDMFGJYCBB UHFFFAOYSA N CASNo 66 72 8 CASNo Ref cascite correct CAS CASOther br 65 22 5 hydrochloride Also CAS verified PubChem 1050 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 1021 DrugBank Ref drugbankcite correct drugbank DrugBank DB00147 ChEBI Ref ebicite correct EBI ChEBI 17310 SMILES O Cc1c cnc c1O C CO Section2 Chembox Properties Formula C sub 8 sub H sub 9 sub NO sub 3 sub MolarMass 167.16 g mol MeltingPt 165 C decomp. Section3 Chembox Related Function arylformaldehydes OtherFunctn Damnacanthal br Gossypol Pyridoxal is one of the three natural forms of vitamin B6 vitamin B sub 6 sub , along with pyridoxamine and pyridoxine also called pyridoxol . All of these forms are converted in the human body into a single biologically active form, Pyridoxal phosphate pyridoxal 5 phosphate . All three forms of vitamin B sub 6 sub are heterocyclic compound heterocyclic organic compound s. Green plants are a natural source of pyridoxal, and its deficiency in the human body can lead to serious complications such as epilepsy and seizures. There are generally three pyridoxal phosphate PLP reactions transamination, alpha elimination, and beta elimination. Pyridoxal is involved in what is believed to be the most ancien ... more details
enzyme Name CDP 4 dehydro 6 deoxyglucose reductase EC number 1.17.1.1 CAS number 37256 87 4 IUBMB EC number 1 17 1 1 GO code 0047099 image width caption CDP 4 dehydro 6 deoxyglucose reductase EC number 1.17.1.1 is an enzyme that catalysis catalyzes the chemical reaction CDP 4 dehydro 3,6 dideoxy D glucose NAD P H sub 2 sub O math rightleftharpoons math CDP 4 dehydro 6 deoxy D glucose NAD P H H sup sup The 4 substrate biochemistry substrates of this enzyme are CDP 4 dehydro 3,6 dideoxy D glucose , nicotinamide adenine dinucleotide ion, nicotinamide adenine dinucleotide phosphate ion, and water , whereas its 4 product chemistry products are CDP 4 dehydro 6 deoxy D glucose , nicotinamide adenine dinucleotide, nicotinamide adenine dinucleotide phosphate, and hydrogen ion . This enzyme belongs to the family of oxidoreductase s, specifically those acting on CH or CH2 group with NAD or NADP as acceptor. The systematic name of this enzyme class is CDP 4 dehydro 3,6 dideoxy D glucose NAD P 3 oxidoreductase . Other names in common use include CDP 4 keto 6 deoxyglucose reductase , cytidine diphospho 4 keto 6 deoxy D glucose reductase , cytidine diphosphate 4 keto 6 deoxy D glucose 3 dehydrogenase , CDP 4 keto deoxy glucose reductase , CDP 4 keto 6 deoxy D glucose 3 dehydrogenase system , and NAD P H CDP 4 keto 6 deoxy D glucose oxidoreductase . This enzyme participates in starch and sucrose metabolism . References reflist 1 cite journal author Pape H, Strominger JL date 1969 title Enzymatic synthesis of cytidine diphosphate 3,6 dideoxyhexoses. V Partial purification of the two protein components required for introduction of the 3 deoxy group journal J. Biol. Chem. volume 244 pages 3598&ndash 604 pmid 4389672 issue 13 cite journal author Rubenstein PA, Strominger JL date 1974 title Enzymatic synthesis of cytidine diphosphate 3,6 dideoxyhexoses. 8 Mechanistic roles of enzyme E 1 and pyridoxamine 5 phosphate in the formation of cytidine diphosphate 4 keto 3,6 dideoxy D glucose fr ... more details
Pyrethrin Pyridoxine or pyridoxamine Vitamin B6 Pyrrolysine Pyruvic acid Q Quinone R Radicicol ... adenine Vitamin B5 Vitamin B sub 5 sub pantothenic acid Vitamin B6 Vitamin B sub 6 sub pyridoxine or pyridoxamine ... more details
This is a list of micronutrient s. tocright Vitamins Vitamin A Vitamin A retinol Vitamin B complex Vitamin B1 Vitamin B sub 1 sub thiamin Vitamin B2 Vitamin B sub 2 sub riboflavin Vitamin B3 Vitamin B sub 3 sub niacin Vitamin B5 Vitamin B sub 5 sub pantothenic acid Vitamin B6 Vitamin B sub 6 sub group Pyridoxine Pyridoxal Pyridoxamine Biotin Vitamin B sub 7 sub biotin Ergadenylic acid Vitamin B sub 8 sub ergadenylic acid Folic acid Vitamin B sub 9 sub folic acid Vitamin B12 Vitamin B sub 12 sub cyanocobalamin Choline Vitamin C Vitamin C Ascorbic acid Vitamin D Vitamin E Vitamin E tocopherol Vitamin K Carotenoid s Alpha carotene Beta carotene Cryptoxanthin Lutein Lycopene Zeaxanthin Dietary mineral Macrominerals Macrominerals Calcium Chloride Magnesium Phosphorus Potassium Sodium Iron Dietary mineral Trace minerals Trace minerals Boron Cobalt Chloride Chromium Copper Main Copper in health Fluoride Iodine Iron Manganese Molybdenum Selenium Zinc Organic Acids Acetic acid Citric acid Lactic acid Malic acid Choline Taurine Dietary supplements not listed above Nutrients 5 HTP higher bioavailable form of tryptophan , precursor to the neurotransmitter serotonin , promotes relaxed poise and sound sleep. Alpha GPC L alpha glycerylphosphorylcholine, Choline alfoscerate most effective choline precursor, readily crosses the blood brain barrier. Caffeine improves concentration, idea production, but hinders memory encoding. Also produces jitters. Carnitine Acetyl L carnitine Acetyl L carnitine ALCAR Amino acid. Transports fatty acids through cellular membranes and cytosol into cells mitochondria, where the fats undergo oxidation to produce ATP, the universal energy molecule. Synergistic with lipoic acid . Precursor of acetylcholine donating the acetyl portion . Inhibits lipofuscin formation. CDP Choline Cytidine diphosphate choline Cytidine Diphosphate Choline choline precursor, a more economical alternative to Alpha GPC. Chondroitin sulfate Coenzyme q 10 increases oxygen transpor ... more details
Refimprove date April 2010 Infobox scientist name Steven C. Zimmerman image SCZimmerman.jpg image size 170px caption Steven C. Zimmerman birth date 1957 birth place Chicago, IL death date death place residence United States U.S. nationality American field Chemistry work institution University of Illinois alma mater Columbia University br University of Wisconsin doctoral advisor Ronald Breslow doctoral students prizes Professor Steven C. Zimmerman is an organic chemist on the faculty of the Department of Chemistry, University of Illinois at Urbana Champaign. Early life and education He was born in Chicago in 1957, the second son of the organic chemist Howard Zimmerman . ref name one Zeng, F. Zimmerman, S. C. Dendrimers in supramolecular chemistry from molecular recognition to self assembly, Chem. Rev. 1997, 97, 1681 1712. ref He attended public schools in Madison, Wisconsin where he received a B.S. degree in 1979 working for Hans J. Reich. In 1983 he received a Ph.D. at Columbia University in New York City where he worked with Ronald Breslow on pyridoxamine enzyme analogs. Career After an NSF NATO Postdoctoral Fellowship at the University of Cambridge with Sir Alan R. Battersby , he joined the faculty at the University of Illinois 1985 . He was appointed the Roger Adams Professor of Chemistry at the University of Illinois at Urbana Champaign in 2004, having previously held a William H. and Janet G. Lycan Professorship. Administrator Zimmerman has served as the Head of the http chemistry.illinois.edu University of Illinois Department of Chemistry from 1999 to 2000 and since 2005. As Department Head he manages an academic staff of 115 full time equivalents FTE with a State budget of 8.4 M and total expenditures of 26.7M, including federal research grants and contracts. ref name eight Figures from 2009 provided by the University of Illinois, Division of Management Information database, Urbana, Illinois. ref He oversees a 60M fundraising campaign and secured the three la ... more details
Orphan date February 2009 PBB geneid 55163 Pyridoxine 5 phosphate oxidase is an enzyme that in humans is encoded by the PNPO gene . ref name pmid9601034 cite journal author Ngo EO, LePage GR, Thanassi JW, Meisler N, Nutter LM title Absence of pyridoxine 5 phosphate oxidase PNPO activity in neoplastic cells isolation, characterization, and expression of PNPO cDNA journal Biochemistry volume 37 issue 21 pages 7741 8 year 1998 month Jun pmid 9601034 pmc doi 10.1021 bi972983r ref ref name pmid15182361 cite journal author Kang JH, Hong ML, Kim DW, Park J, Kang TC, Won MH, Baek NI, Moon BJ, Choi SY, Kwon OS title Genomic organization, tissue distribution and deletion mutation of human pyridoxine 5 phosphate oxidase journal Eur J Biochem volume 271 issue 12 pages 2452 61 year 2004 month Jun pmid 15182361 pmc doi 10.1111 j.1432 1033.2004.04175.x ref ref name entrez cite web title Entrez Gene PNPO pyridoxamine 5 phosphate oxidase url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 55163 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Vitamin B sub 6 sub , or pyridoxal 5 prime phosphate PLP , is critical for normal cellular function, and some cancer cells have notable differences in vitamin B sub 6 sub metabolism compared to their normal counterparts. The rate limiting enzyme in vitamin B sub 6 sub synthesis is pyridoxine 5 prime phosphate PNP oxidase PNPO EC 1.4.3.5 . supplied by OMIM ref name entrez Model organisms class wikitable sortable collapsible collapsed border 1 cellpadding 2 style float right Pnpo knockout mouse phenotype Characteristic Phenotype Homozygote viability bgcolor C40000 Abnormal Recessive lethal study bgcolor C40000 Abnormal Fertility bgcolor 488ED3 Normal Body weight bgcolor 488ED3 Normal Open Field animal test Anxiety bgcolor 488ED3 Normal Neurological assessment bgcolor 488ED3 Normal Grip strength bg ... more details
enzyme Name aspartate transaminase EC number 2.6.1.1 CAS number 9000 97 9 IUBMB EC number 2 6 1 1 GO code 0004069 image Aspartate transaminase.png width caption Aspartate aminotransferase from E. coli Escherichia coli bound with cofactor Pyridoxal phosphate pyridoxal 5 phosphate . ref name pmid7909946 PDB 1AAM cite journal author Almo SC, Smith DL, Danishefsky AT, Ringe D title The structural basis for the altered substrate specificity of the R292D active site mutant of aspartate aminotransferase from E. coli journal Protein Eng. volume 7 issue 3 pages 405 412 year 1994 month March pmid 7909946 doi 10.1093 protein 7.3.405 url issn ref Aspartate transaminase AST , also called aspartate aminotransferase AspAT ASAT AAT or serum glutamic oxaloacetic transaminase SGOT , is a pyridoxal phosphate PLP dependent transaminase enzyme EC number 2.6.1.1 . AST catalyzes the reversible transfer of an amino group between aspartate and glutamate and, as such, is an important enzyme in amino acid metabolism. AST is found in the liver , heart , skeletal muscle , kidneys , brain , and red blood cells, and it is commonly measured clinically as a marker for liver health. Function Aspartate transaminase catalyzes the interconversion of aspartate and ketoglutarate to oxaloacetate and glutamate . Aspartate Asp ketoglutarate oxaloacetate glutamate Glu File Aspartate aminotransferase reaction.png thumb 450px Reaction catalyzed by aspartate aminotransferase As a prototypical transaminase, AST relies on PLP as a cofactor to transfer the amino group from aspartate or glutamate to the corresponding ketoacid . In the process, the cofactor shuttles between PLP and the pyridoxamine phosphate PMP form. ref name pmid6143829 cite journal author Kirsch JF title Mechanism of action of aspartate aminotransferase proposed on the basis of its spatial structure journal J Mol Biol year 1984 volume 174 issue 3 pages 497 525 pmid 6143829 doi 10.1016 0022 2836 84 90333 4 pmc url http www.ncbi.nlm.nih.gov e ... more details
phenylpyruvate transaminase EC number 2.6.1.29 diamine transaminase EC number 2.6.1.30 pyridoxamine pyruvate transaminase EC number 2.6.1.31 pyridoxamine oxaloacetate transaminase EC number ... number 2.6.1.52 phosphoserine transaminase EC number 2.6.1.53 now EC 1.4.1.13 EC number 2.6.1.54 pyridoxamine ... more details
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