A spliceosome is a complex of snRNA and protein subunits that removes intron s from a Transcription genetics ... genetics splicing . Request for illustration of spliceosome Composition Each spliceosome is composed ... that make up the cell nucleus nuclear spliceosome are named U1 snRNA U1 , U2 snRNA U2 , U4 snRNA ... the nucleoside analog of the uracil nucleotide . The canonical assembly of the spliceosome ... and utilized during spliceosome assembly. These include the 5 end splice, the branch point sequence, the polypyrimidine tract, and the 3 end splice site. The spliceosome catalyzes the removal of introns ... spliceosome that splices a rare class of pre mRNA introns, denoted U12 type. These snRNPs form the U12 spliceosome are located in the cytosol . ref name pmid18022366 cite journal author K nig H, Matter N, Bader R, Thiele W, M ller F title Splicing Segregation The Minor Spliceosome Acts outside the Nucleus ... II intron suggests that the spliceosome is actually a ribozyme , and that it uses a two metal ... or Medicine for their discovery of introns and the splicing process. Spliceosome assembly The model for formation of the spliceosome active site involves an ordered, stepwise assembly of discrete ... 12 author Jamison SF, Crow A, and Garcia Blanco MA date October 1, 1992 title The spliceosome assembly ... complexes committed to spliceosome assembly and splicing author Seraphin B. and Rosbash M. year 1989 ... Legrain P, Seraphin B, Rosbash M title Early commitment of yeast pre mRNA to the spliceosome pathway ... nsb873 issue 12 ref The U4 U5 U6 tri snRNP see Figure 1 is recruited to the assembling spliceosome to form complex B, and following several rearrangements, complex C the spliceosome is activated for catalysis ... author Staley JP, Guthrie C title Mechanical devices of the spliceosome motors, clocks, springs, and things ... active spliceosome. Several of the RNA RNA interactions are mutually exclusive however, it is not known ... title Evidence for two active sites in the spliceosome provided by stereochemistry of pre mRNA splicing ... more details
The minor spliceosome is a ribonucleoprotein complex that catalyses the removal splicing genetics splicing of an atypical class of spliceosomal introns U12 type from eukaryotic messenger RNA s in plant, insects, vertebrates and some fungi Rhizopus oryzae . This process is called noncanonical splicing, as opposed to U2 dependent canonical splicing. U12 type introns represent less than 1 of all introns in human cells. However they are found in genes performing essential cellular functions. Image Pre mRNA to mRNA.svg right thumbnail 350px right Simple illustration of exons and introns in pre mRNA ... complexes. Structure of U12 type introns and minor spliceosome Although originally referred ... site sequences. Minor spliceosome consists of U11 spliceosomal RNA U11 , U12 minor spliceosomal ... RNA U4 U6 spliceosomal RNA U6 snRNPs in major spliceosome. ref cite journal author Hall SL ... science.271.5256.1716 ref ref cite journal author Tarn WY, Steitz JA title A novel spliceosome ... spliceosome is regarded by most experts to be in the nucleus. However, a single paper has claimed that the minor spliceosome is active in the cytosol. ref cite journal author K nig H, Matter N, Bader R, Thiele W, M ller F title Splicing segregation the minor spliceosome acts outside the nucleus and controls ... within the field and directly contradict numerous other papers. Evolution of minor spliceosome Like major spliceosome, minor spliceosome had an early origin several of its characteristic constituents ... spliceosome journal Biol. Chem. volume 386 issue 8 pages 713 24 year 2005 month August pmid ... pmc 328465 cite journal author Tarn WY, Steitz JA title A novel spliceosome containing U11 ... AG, Charette JM, Spencer DF, Gray MW title An early evolutionary origin for the minor spliceosome ... Other references reflist See also Spliceosome RNA splicing Category Organelles Category Gene expression Category RNA Category Spliceosome Category RNA splicing fr Splic osome mineur ... more details
A splicing factor is a protein involved in the removal of introns and from strings of messenger RNA , so that the exons can bind together the process takes place in particles known as spliceosomes . Category biochemistry Category Spliceosome protein stub ... more details
Orphan date April 2012 Dr. Saba Valadkhan is an Iranian American biomedical scientist, and an Assistant Professor and RNA researcher at Case Western Reserve University . In 2005 , she was awarded the GE Science journal Science http www.sciencemag.org feature data pharmacia prize howto.shl Young Scientist Award for her breakthrough in understanding the mechanism of spliceosome s akin to finding the Holy Grail of the Splicing genetics splicing catalysis field http www.payvand.com news 05 aug 1088.html a critical area of research, given that 20 percent or 30 percent of all human genetic diseases are caused by mistakes that the spliceosome makes http www.aaas.org news releases 2005 0210ys Valadkhan.shtml . Valadkhan qualified as a medical doctor in Iran , before moving to the United States to pursue post graduate study at Columbia University in New York . The main focus of her research is elucidating the structure and function of the catalytic core of the spliceosome by taking advantage of a novel, minimal spliceosome she recently developed. This minimal system, which consists of only two spliceosomal snRNAs, catalyzes a reaction identical to the splicing reaction. In addition to providing direct evidence for RNA catalysis in the spliceosome, and thus, settling the longstanding and central question of the identity of the catalytic domain, the minimal system provides a novel and powerful tool for studying the structure and function of the spliceosome. External links http www.mideastyouth.com 2008 12 24 interview with the iranian genius of biomedicine Interview http www.aaas.org news releases 2005 0210ys Valadkhan.shtml Interview http www.rnaresearch.org valadkhan.htm Departmental website http www.case.edu admin aces valadkhan.htm Faculty page http www.payvand.com news 05 aug 1088.html Young Scientist Award report See also List of famous Persian women List of famous Iranian women Persondata Metadata see Wikipedia Persondata . NAME Valadkhan, Saba ALTERNATIVE NAMES SHORT D ... more details
PBB geneid 100151683 RNA, U4atac small nuclear U12 dependent splicing is a small nuclear RNA that in humans that is encoded by the RNU4ATAC gene . ref name entrez cite web title Entrez Gene RNA, U4atac small nuclear U12 dependent splicing url http www.ncbi.nlm.nih.gov sites entrez?db gene&cmd retrieve&list uids 100151683 accessdate 2012 04 15T07 16 19.080802 08 00 ref The small nuclear RNA snRNA encoded by this gene is part of the U12 dependent minor spliceosome complex. In addition to the encoded RNA, this ribonucleoprotein complex consists of U11, U12, U5, and U6atac snRNAs. The U12 dependent spliceosome acts on approximately 700 specific introns in the human genome. Defects in this gene are a cause of microcephalic osteodysplastic primordial dwarfism type 1 MOPD . ref name entrez References reflist Further Reading refbegin 2 Cite pmid 21474761 Cite pmid 21474760 Cite pmid 21990275 Cite pmid 2409455 Cite pmid 14691257 Cite pmid 8791582 Cite pmid 12374753 refend gene 1 stub ... more details
in U4atac snRNA, a Component of the Minor Spliceosome, in the Developmental Disorder MOPD I journal ... Non coding RNA Category Spliceosome Category RNA splicing molecular cell biology stub fr ARN splic osomal ... more details
Infobox rfam Name U5 spliceosomal RNA image RF00020.jpg width caption Predicted secondary structure and sequence conservation of U5 Symbol U5 AltSymbols Rfam RF00020 miRBase miRBase family RNA type Gene Small nuclear RNA snRNA RNA splicing splicing Tax domain Eukaryota GO GO 0000351 GO 0000353 GO 0005682 GO 0046540 SO SO 0000395 CAS number EntrezGene HGNCid OMIM PDB RefSeq Chromosome Arm Band LocusSupplementaryData U5 RNA is a non coding RNA that is a component of both types of known spliceosome . ref name pmid8702566 cite journal author Hinz M, Moore MJ, Bindereif A title Domain analysis of human U5 RNA. Cap trimethylation, protein binding, and spliceosome assembly journal J. Biol. Chem. volume 271 issue 31 pages 19001 19007 year 1996 month August pmid 8702566 doi 10.1074 jbc.271.31.19001 url issn ref The precise function of this molecule is unknown, though it is known that the 5 loop is required for splice site selection and p220 binding, and that both the 3 stem loop and the Sm site are important for Sm protein binding and cap methylation. References reflist 1 Further reading refbegin cite journal last Zwieb first C year 1997 title The uRNA database journal Nucleic Acids Res volume 25 pages 102&ndash 103 pmid 9016512 doi 10.1093 nar 25.1.102 issue 1 pmc 146409 cite journal last Thomas first J coauthors Lea K, Zucker Aprison E, Blumenthal T year 1990 title The spliceosomal snRNAs of Caenorhabditis elegans journal Nucleic Acids Res volume 18 pages 2633&ndash 2642 pmid 2339054 doi 10.1093 nar 18.9.2633 issue 9 pmc 330746 refend External links Rfam id RF00020 name U5 spliceosomal RNA Category Small nuclear RNA Category Spliceosome Category RNA splicing molecular cell biology stub fr ARN splic osomal U5 ... more details
Image Ppy tract 2g4b.png thumb 300px The essential spliceosome component U2AF bound to a short polypyrimidine RNA fragment. The polypyrimidine tract is a region of messenger RNA mRNA that promotes the assembly of the spliceosome , the protein complex specialized for carrying out RNA splicing during the process of post transcriptional modification . The region is rich with pyrimidine nucleotide s, especially uracil , and is usually 15 20 base pair s long, located about 5 40 base pairs before the 3 end of the intron to be spliced. ref name Lodish Lodish H, Berk A, Matsudaira P, Kaiser CA, Krieger M, Scott MP, Zipursky SL, Darnell J. 2004 . Molecular Cell Biology. WH Freeman New York, NY. 5th ed. ref A number of protein factors bind to or associate with the polypyrimidine tract, including the spliceosome component U2AF and the polypyrimidine tract binding protein PTB , which plays a regulatory role in alternative splicing . PTB s primary function is in exon silencing, by which a particular exon region normally spliced into the mature mRNA is instead left out, resulting in the gene expression expression of an isoform of the protein for which the mRNA genetic code codes . Because PTB is ubiquitously expressed in many higher eukaryote s, it is thought to suppress the inclusion of weak exons with poorly defined splice site s. ref name Wagner Wagner EJ, Garcia Blanco MA. 2001 . Polypyrimidine tract binding protein antagonizes exon definition. Mol Cell Biol 21 10 3281 3288. ref However, PTB binding is not sufficient to suppress robust exons. ref name Gooding Gooding C, Roberts GC, Smith CW. 1998 . Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated alpha tropomyosin exon. RNA 4 85 100. ref The suppression or selection of exons is critical to the proper expression of biological tissue tissue specific isoforms. For example ... Category Gene expression Category Spliceosome ... more details
catalyzed by the spliceosome , a complex of small nuclear ribonucleoproteins snRNP s , but there are also ... title RNA Splicing Introns, Exons and Spliceosome journal Nature Education year 2008 volume 1 issue 1 url http www.nature.com scitable topicpage rna splicing introns exons and spliceosome 12375 accessdate ... as a Indel deletion in the final protein. Image Intron miguelferig.jpg 450px center Spliceosome formation and activity Splicing is catalyzed by the spliceosome which is a large RNA protein complex ... been identified the major and minor which contain different snRNP s. Major The major spliceosome splices ... including U2AF2 U2AF and SF1 gene SF1 are required for the assembly of the spliceosome. ref name Black ... splicing is said to occur see minor spliceosome below . ref cite journal author Ng B, Yang F, Huston ... spliceosome is very similar to the major spliceosome, however it splices out rare introns with different ... , the minor spliceosome has different, but functionally analogous snRNPs for U1, U2, U4, and U6, which .... ref cite journal author Patel AA, Steitz JA title Splicing double insights from the second spliceosome ... doi 10.1038 nrm1259 ref Like the major spliceosome, it is only found in the nucleus. ref cite journal ... , performing the functions of the spliceosome by RNA alone. There are three kinds of self splicing ... III . Group I and II introns perform splicing similar to the spliceosome without requiring any protein. This similarity suggests that Group I and II introns may be evolutionarily related to the spliceosome ... that is defined during spliceosome assembly performs a nucleophilic attack on the first nucleotide ... 6 pmid 15759099 ref See also Commons category Splicing cDNA Exon Intron Primary transcript Spliceosome Minor spliceosome Exon Junction Complex References Reflist 2 External links http vcell.ndsu.nodak.edu ... expression Category Spliceosome Category RNA splicing an Adchuste d ARN ca Empalmament cs Splicing ... more details
Infobox rfam Name U11 spliceosomal RNA image RF00548.jpg width caption Predicted secondary structure and sequence conservation of U11 Symbol U11 AltSymbols Rfam RF00548 miRBase miRBase family RNA type Gene Small nuclear RNA snRNA RNA splicing splicing Tax domain Eukaryota GO GO 0000369 GO 0030627 GO 0005692 SO SO 0000398 CAS number EntrezGene HGNCid OMIM PDB RefSeq Chromosome Arm Band LocusSupplementaryData The U11 spliceosomal RNA is a non coding RNA that together with U4atac U6atac, U5, and U12 snRNAs and associated proteins, forms a spliceosome that cleaves a divergent class of low abundance pre mRNA introns. References reflist 1 1 cite journal last Montzka first KA coauthors Steitz JA year 1988 title Additional low abundance human small nuclear ribonucleoproteins U11, U12, etc journal Proc Natl Acad Sci USA volume 85 pages 8885&ndash 8889 pmid 2973606 doi 10.1073 pnas.85.23.8885 issue 23 pmc 282611 2 cite journal last Schneider first C coauthors Will CL, Brosius J, Frilander MJ, Luhrmann R year 2004 title Identification of an evolutionarily divergent U11 small nuclear ribonucleoprotein particle in Drosophila journal Proc Natl Acad Sci USA volume 101 pages 9584&ndash 9589 pmid 15210936 doi 10.1073 pnas.0403400101 issue 26 pmc 470718 External links Rfam id RF00548 name U11 spliceosomal RNA Category Small nuclear RNA Category Spliceosome Category RNA splicing molecular cell biology stub ... more details
Infobox rfam Name U2 spliceosomal RNA image RF00004.jpg width caption Predicted secondary structure and sequence conservation of U2 Symbol U2 AltSymbols Rfam RF00004 miRBase miRBase family RNA type Gene Small nuclear RNA snRNA RNA splicing splicing Tax domain Eukaryota GO GO 0000370 GO 0045131 GO 0005686 SO SO 0000392 CAS number EntrezGene HGNCid OMIM PDB RefSeq Chromosome Arm Band LocusSupplementaryData U2 spliceosomal RNA is a small nuclear RNA snRNA component of the spliceosome involved in pre mRNA splicing . Complementarity molecular biology Complementary binding between U2 snRNA in an area lying towards the 5 end but 3 to hairpin I and the branchpoint sequence BPS of the intron results in the bulging out of an unpaired adenosine , on the BPS, which initiates a Nucleophile nucleophilic attack at the intronic 5 splice site, thus starting the first of two transesterification reactions that mediate splicing. References reflist 1 cite journal last Newby first MI coauthors Greenbaum NL year 2001 title A conserved pseudouridine modification in eukaryotic U2 snRNA induces a change in branch site architecture journal RNA volume 7 pages 833 845 pmid 11424937 doi 10.1017 S1355838201002308 issue 6 pmc 1370140 cite journal last Berglund first JA coauthors Rosbash M, Schultz SC year 2001 title Crystal structure of a model branchpoint U2 snRNA duplex containing bulged adenosines journal RNA volume 7 pages 682 691 pmid 11350032 doi 10.1017 S1355838201002187 issue 5 pmc 1370120 External links Rfam id RF00004 name U2 spliceosomal RNA http web.archive.org web 20050913043846 http psyche.uthct.edu dbs uRNADB u2 u2.html U2 molecular cell biology stub Category Small nuclear RNA Category Spliceosome Category RNA splicing fr ARN splic osomal U2 ... more details
Infobox rfam Name Yeast U1 spliceosomal RNA image RF00488.jpg width caption Predicted secondary structure and sequence conservation of U1 yeast Symbol U1 yeast AltSymbols Rfam RF00488 miRBase miRBase family RNA type Gene Small nuclear RNA snRNA RNA splicing splicing Tax domain Eukaryota GO GO 0000368 GO 0030627 GO 0005685 SO SO 0000391 CAS number EntrezGene HGNCid OMIM PDB RefSeq Chromosome Arm Band LocusSupplementaryData U1 is a small nuclear RNA snRNA component of the spliceosome and is involved in pre mRNA splicing genetics splicing . In the splicing process the 5 end of the U1 snRNA forms complementary base pairing with the 5 splice junction of the inton to be excised, thus defining the 5 donor site of an intron. There are significant differences in sequence and secondary structure between metazoan and yeast U1 snRNAs, the latter being much longer 568 nucleotides as compared to 164 nucleotides in human . Nevertheless, secondary structure predictions suggest that all U1 snRNAs share a common core consisting of helices I, II, the proximal region of III, and IV ref name pmid9016512 cite journal author Zwieb C title The uRNA database journal Nucleic Acids Res. volume 25 issue 1 pages 102 3 year 1997 pmid 9016512 doi 10.1093 nar 25.1.102 pmc 146409 ref ref name pmid2405391 cite journal author Kretzner L, Krol A, Rosbash M title Saccharomyces cerevisiae U1 small nuclear RNA secondary structure contains both universal and yeast specific domains journal Proc. Natl. Acad. Sci. U.S.A. volume 87 issue 2 pages 851 5 year 1990 pmid 2405391 doi 10.1073 pnas.87.2.851 pmc 53364 ref . The secondary structure model shows the structure prediction for the larger yeast sequences. References references External links Rfam id RF00488 name Yeast U1 spliceosomal RNA molecular cell biology stub Category Small nuclear RNA Category Spliceosome Category RNA splicing ... more details
the modification of RNA polymerase II transcribed spliceosome spliceosomal RNAs U1 spliceosomal ... Category Non coding RNA Category Small nuclear RNA Category Spliceosome Category RNA splicing biochem ... more details
U6 or U 6 may refer to German submarine U 6 German submarine U 6 , one of several German submarines U 6, a railway line on several German Rapid transit underground railway systems U6 Berlin U Bahn U6 U Bahn line , a line on the Berlin U Bahn U 6, a line on the Frankfurt U Bahn U 6, a line on the Munich U Bahn U 6, a line on the Vienna U Bahn The IATA airline designator code for Ural Airlines Any context link for this? U6 student organization Joint University students of California British NVC community U6 , Juncus squarrosus Festuca ovina grassland, one of the calcifugous grassland communities of the British National Vegetation Classification Ultima VI , a computer role playing game U6, an Unemployment United States Bureau of Labor Statistics unemployment figure released by the United States Bureau of Labor Statistics U6 promotor biology promoter , a gene playing an important role in the synthesis of shRNA Haplogroup U6 U6 spliceosomal RNA , a small nuclear RNA component of the spliceosome 1962 United States Tri Service aircraft designation system US military designation for the de Havilland Canada DHC 2 Beaver DHC 2 Beaver aircraft Letter NumberCombDisambig de U 6 et U6 es U 6 fr U6 it U6 nl U6 pl U 6 ru U 6 ... more details
U 4 , U04 or U4 may refer to U4 Berlin U Bahn , a subway line in Berlin, Germany U4 Frankfurt U Bahn , a subway line in Frankfurt, Germany U4 spliceosomal RNA , a non coding RNA component of the major U2 dependent spliceosome Anti Corruption Resource Centre , based at the Chr. Michelsen Institute in Bergen, Norway German submarine U 4 German submarine U 4 , one of several German submarines Haplogroup U4 mtDNA , a human genetic group London Buses route U4 U 4, the U.S. Air Force version of the Aero Commander aircraft , a light twin engined aircraft from Aero Design and Engineering Company U 4, the Japanese air self defense force designation for the Gulfstream IV aircraft U4, an Unemployment United States Bureau of Labor Statistics unemployment figure released by the United States Bureau of Labor Statistics U04, Severe acute respiratory syndrome ICD 10 code U4, a Hamburg U Bahn line U4, a Munich U Bahn line U4, a Vienna U Bahn line U4, PMTair former IATA airline designator U4, Buddha Air current IATA airline designator U4, Unitary group unitairy group of degree 4 See also 4U disambiguation Letter NumberCombDisambig de U 4 et U4 es U 4 fr U4 it U4 nl U4 ja U4 pl U 4 ru U 4 ... more details
Orphan date February 2009 PBB geneid 10285 Survival of motor neuron related splicing factor 30 is a protein that in humans is encoded by the SMNDC1 gene . ref name pmid9731529 cite journal author Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M title Mass spectrometry and EST database searching allows characterization of the multi protein spliceosome complex journal Nat Genet volume 20 issue 1 pages 46 50 year 1998 month Oct pmid 9731529 pmc doi 10.1038 1700 ref ref name pmid9817934 cite journal author Talbot K, Miguel Aliaga I, Mohaghegh P, Ponting CP, Davies KE title Characterization of a gene encoding survival motor neuron SMN related protein, a constituent of the spliceosome complex journal Hum Mol Genet volume 7 issue 13 pages 2149 56 year 1999 month Jan pmid 9817934 pmc doi 10.1093 hmg 7.13.2149 ref ref name entrez cite web title Entrez Gene SMNDC1 survival motor neuron domain containing 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 10285 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Rappsilber J, Ajuh P, Lamond AI, Mann M title SPF30 is an essential human splicing factor required for assembly of the U4 U5 U6 tri small nuclear ribonucleoprotein into the spliceosome. journal J. Biol. Chem. volume 276 issue 33 pages 31142 50 year 2001 pmid 11331295 doi 10.1074 jbc.M103620200 cite journal author Meister G, Hannus S, Pl ttner O, et al. title SMNrp is an essential pre mRNA splicing factor required for the formation of the mature spliceosome. journal EMBO J. volume 20 issue 9 pages 2304 14 year 2001 pmid 11331595 doi 10.1093 emboj 20.9.2304 pmc 125440 cite journal author Strausberg RL, Feingold EA, Grouse LH, et al. title Generation and initial analysis of more than 15,00 ... more details
Image 2 O methyl adenosine.GIF thumb 2 O methyl adenosine, a modified adenosine . 2 O methylation is a common nucleoside modification of RNA , where a methyl group is added to the nucleic acid nomenclature 2 hydroxyl group of the ribose moiety of a nucleoside. 2 O methylated nucleosides are found in the functionally essential regions of the ribosome and spliceosome . ref cite journal author Kiss T title Small nucleolar RNA guided post transcriptional modification of cellular RNAs journal EMBO J. volume 20 issue 14 pages 3617 22 year 2001 url http www.nature.com emboj journal v20 n14 full 7593858a.html doi 10.1093 emboj 20.14.3617 pmid 11447102 pmc 125535 ref Also, 2 O methylation of adenosine in an RNA prevents ADAR adenosine deaminase from editing it to an inosine . ref cite journal author Beal PA, Maydanovych O, Pokharel S title The chemistry and biology of RNA editing by adenosine deaminases journal Nucleic Acids Symposium Series date 2007 doi 10.1093 nass nrm042 pages 83 84 volume 51 issue 1 pmid 18029597 ref See also Small nucleolar RNA References references Category RNA molecular biology stub ... more details
Nucleic acid structure refers to the Biomolecular structure structure of nucleic acid s such as DNA and RNA It is often divided into four different levels Nucleic acid primary structure Primary structure &mdash the raw sequence of nucleobase s of each of the component DNA strands Nucleic acid secondary structure Secondary structure &mdash the set of interactions between bases, i.e., which parts of which strands are bound to each other Nucleic acid tertiary structure Tertiary structure &mdash the locations of the atoms in three dimensional space, taking into consideration geometrical and steric constraints and Nucleic acid quaternary structure Quaternary structure &mdash the higher level organization of DNA in chromatin, or to the interactions between separate RNA units in the ribosome or spliceosome . See also Nucleic acid double helix Nucleic acid structure determination experimental Nucleic acid structure prediction computational DNA nanotechnology Nucleic acid design Nucleic acid thermodynamics Crosslinking of DNA DNA supercoil molecular biology stub Biomolecular structure Category DNA Category RNA ca Estructura de l ADN es Estructura del cido nucleico tr DNA n n yap s zh DNA ... more details
Orphan date January 2011 infobox biodatabase title TassDB logo File Database.png description alternative tandem splice site s. scope organism center laboratory author pmid Hiller & al. 2007 ref name pmid17142241 released 2006 standard format url http helios.informatik.uni freiburg.de TassDB download webservice sql sparql webapp standalone license versioning frequency curation bookmark version TassDB TAndem Splice Site DataBase is a database of tandem splice site s of eight species ref name pmid17142241 cite journal quotes yes last Hiller first Michael authorlink coauthors Nikolajewa Swetlana, Huse Klaus, Szafranski Karol, Rosenstiel Philip, Schuster Stefan, Backofen Rolf, Platzer Matthias year 2007 month Jan title TassDB a database of alternative tandem splice sites journal Nucleic Acids Res. volume 35 issue Database issue pages D188 92 publisher location England issn pmid 17142241 doi 10.1093 nar gkl762 bibcode oclc id url pmc 1669710 language eng format accessdate laysummary laysource laydate quote ref See also Alternative splicing References references External links http helios.informatik.uni freiburg.de TassDB . Category Biological databases Category Gene expression Category Spliceosome Category RNA splicing Biodatabase stub ... more details
self published date August 2011 Orphan date January 2011 infobox biodatabase title DBASS3 and DBASS5 logo File Database.png description databases of aberrant 3 and 5 RNA splicing splice sites. scope organism center laboratory International Centre for Genetic Engineering and Biotechnology,Italy. author Emanuele Buratti pmid Buratti & al. 2011 ref name pmid20929868 released 2010 standard format url http www.dbass.org.uk download webservice sql sparql webapp standalone license versioning frequency curation bookmark version DBASS3 and DBASS5 is a database of new exon boundaries induced by pathogenic mutation s in Human diseases marker human disease genes. ref name pmid20929868 cite journal quotes yes last Buratti first Emanuele authorlink coauthors Chivers Martin, Hwang Gyulin, Vorechovsky Igor year 2011 month Jan title DBASS3 and DBASS5 databases of aberrant 3 and 5 splice sites journal Nucleic Acids Res. volume 39 issue Database issue pages D86 91 publisher location England issn pmid 20929868 doi 10.1093 nar gkq887 bibcode oclc id url pmc 3013770 language eng format accessdate laysummary laysource laydate quote ref See also Human diseases marker s References references External links http www.dbass.org.uk . DEFAULTSORT Dbass3 5 Category Biological databases Category Genes Category Gene expression Category RNA Category Spliceosome Category RNA splicing Biodatabase stub ... more details
primary sources date August 2011 self published date August 2011 infobox biodatabase title EDAS. logo File Database.png description databases of Alternative splicing alternatively spliced human genes. scope organism Homo Sapiens center laboratory author R N Nurtdinov pmid Nurtdinov & al. ref name pmid16909834 released standard format url http www.gene bee.msu.ru edas download webservice sql sparql webapp standalone license versioning frequency curation bookmark version EDAS is a database of Alternative splicing alternatively spliced human genes ref name pmid16909834 cite journal quotes yes last Nurtdinov first R N authorlink coauthors Neverov A D, Mal ko D B, Kosmodem ianski I A, Ermakova E O, Ramenski V E, Mironov A A, Gel fand M S year month title EDAS, databases of alternatively spliced human genes journal Biofizika volume 51 issue 4 pages 589 92 publisher location Russia Federation issn 0006 3029 pmid 16909834 bibcode oclc id url language rus format accessdate laysummary laysource laydate quote ref See also AspicDB database References references External links http www.gene bee.msu.ru edas . Category Biological databases Category Gene expression Category Spliceosome Category RNA splicing Biodatabase stub ... more details
Multiple issues primary sources August 2011 orphan February 2011 self published August 2011 infobox biodatabase title EID logo File Database.png description database of protein coding intron containing genes. scope organism center Harvard University laboratory Department of Molecular Biology author S Saxonov pmid Saxonov & al. 2000 ref name pmid10592221 released standard format url http mcb.harvard.edu gilbert EID download webservice sql sparql webapp standalone license versioning frequency curation bookmark version the Exon Intron Database EID is a database of Alternative splicing spliced mRNA sequences ref name pmid10592221 cite journal quotes yes last Saxonov first S authorlink coauthors Daizadeh I, Fedorov A, Gilbert W year 2000 month Jan title EID the Exon Intron Database an exhaustive database of protein coding intron containing genes journal Nucleic Acids Res. volume 28 issue 1 pages 185 90 publisher location ENGLAND issn 0305 1048 pmid 10592221 bibcode oclc id url pmc 102483 language eng format accessdate laysummary laysource laydate quote doi 10.1093 nar 28.1.185 ref See also Alternative splicing Exon Intron References references External links http www.utoledo.edu med depts bioinfo database.html Category Biological databases Category Gene expression Category Spliceosome Category RNA splicing Biodatabase stub ... more details
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