Infobox protein family Symbol Name image TCRComplex.png width caption The T cellreceptor complex with TCR and TCR chains, CD3 receptor CD3 and chain accessory molecules. Pfam PF11628 Pfam clan InterPro ... CD8 cells or helper CD4 cells. Infobox protein Name T cellreceptor alpha locus caption image width ... 14 Arm q Band 11.2 LocusSupplementaryData Infobox protein Name T cellreceptor beta locus caption ... PDB ECnumber Chromosome 7 Arm q Band 34 LocusSupplementaryData The T cellreceptor or TCR is a molecule ... T cellreceptor mutants from a yeast surface display library journal Proceedings of the National ... in specificity of the T cellreceptor for processed antigen. The TCR complex It is thought that such structure allows the TCR to associate with other molecules like CD3 receptor CD3 , which possess ... is known as the T cellreceptor complex. TCR co receptors The signal from the T cell complex is enhanced by simultaneous binding of the MHC molecules by a specific co receptor . On helper T cells , this co receptor is CD4 that is specific for class II MHC . On cytotoxic T cells , this co receptor ... upon phosphorylation by Lck and Fyn When a T cellreceptor is activated by contact with a peptide ... 2hac Zeta zeta dimer of T cellreceptor MeshName T CellReceptor See also T cell Co stimulation Immune receptors Use dmy dates date February 2011 DEFAULTSORT T CellReceptor Category Cell signaling Category ... T it T cellreceptor pl Receptor kom rek T pt Receptor de c lulas T ru fi Antigeenireseptori ... TCR, which is anchored in the cell membrane, consists of two halves, which form a pair or protein dimer ... V region. The constant region has an end that is anchored in the cell membrane. The variable ... cell membrane spanning region, and a short cytoplasmic tail at the C terminal end. The variable ... described for B cell antigen receptors, otherwise known as immunoglobulin s. The TCR alpha chain ... the signal from the TCR into the cell the cytoplasmic tail of the TCR is extremely short, making ... more details
T cellreceptor excision circles TRECs are small circles of DNA created in T cell s during their passage through the thymus as they rearrange their T cellreceptor TCR genes. ref http allergycases.org 2010 05 t cellreceptor excision circles trecs.html ref Single joint T cellreceptor excision circles sjTRECs are in the news as a way to test the age of the individual from a blood sample. ref http www.telegraph.co.uk science 8153033 New CSI style crime blood test could help police pinpoint suspects age.html telegraph.co.uk ref See also T cellreceptor V D J recombination References reflist Category T cells Genetics stub ... more details
The B cellreceptor is a transmembrane Receptor biochemistry receptor protein located on the Cell membrane outer surface of B cell s. The receptor s binding Moiety chemistry moiety is composed of a membrane bound antibody that, like all antibodies, has a unique and randomly determined antigen binding site. When a B cell is activated by its first encounter with an antigen that binds to its receptor its cognate antigen , the cell proliferates and differentiates to generate a population of antibody secreting plasma B cell s and memory B cell s. Components of the B cellreceptor The B cellreceptor is composed of two parts ref Cite book author Kindt, Thomas J. Goldsby, Richard A. Osborne, Barbara A. Kuby, Janis authorlink coauthors title Kuby immunology date 2007 publisher W.H. Freeman location New York isbn 1 4292 0211 4 pages ref Ligand binding moiety A membrane bound bound immunoglobulin molecule of one isotype IgD, IgM, IgE or IgE . With the exception of the presence of an integral membrane protein integral membrane domain, these are identical to their secreted forms. Signal transduction moiety A heterodimer called CD79A Ig CD79B Ig CD79 , bound together by disulfide bond disulfide bridges . Each member of the dimer spans the plasma membrane and has a cytoplasmic tail bearing an immunoreceptor tyrosine based activation motif immunoreceptor tyrosine based activation motif ITAM . Signaling Pathways of the B CellReceptor There are several signaling pathways that the B CellReceptor can follow through. Of those known, there can be intracellular signaling through the PLCy calcium ... B Cell Antigen Receptors Immune receptors Category Lymphocytes Category Receptors receptor stub cs B bun n receptor fr R cepteur des cellules B pl Receptor kom rek B ... last Kurosaki first Tomohiro coauthors Hisaaki Shinohara, Yoshihiro Baba title B Cell Signaling ... Baba title B Cell Signaling and Fate Decision journal Annual Review of Immunology year 2008 volume 28 ... more details
, growth factors or Cell adhesion molecule cell recognition molecules attach to the receptor biochemistry receptor , triggering changes in the function of the Cell biology cell . This process is called ... anchored membrane receptor for 5 methyltetrahydrofolate journal The Journal of Cell Biology year 1990 ... out of the membrane on the outside of the cell or organelle . If the polypeptide chain of the receptor ... domain of the receptor interacts with the interior of the cell or organelle, relaying the signal. There are two ... by one cell and is capable of traveling to neighboring cells, or to cells that may be far away. Receptor protein the cells in an organism must have cell surface receptor proteins that bind to the signal ... changes induced by receptor binding result in the insertion of the myristic acid on VP4 into the cell ... Affinity Nerve Growth Factor Receptor NMDA receptor Several Immune receptors Toll like receptor T cell ...main Receptor biochemistry File 7TM4 GPCR .png thumb 300px The seven transmembrane helix structure of a G protein coupled receptorCell surface receptors membrane receptors , transmembrane receptors are specialized integral membrane protein s that take part in communication between the cell and the outside ..., while others cross as many as seven times for example, the so called G protein coupled receptor G protein coupled receptor s . There are various kinds, such as glycoprotein and lipoprotein . ref ... D, Spehr M, Rodriguez I title Formyl peptide receptor like proteins are a novel family of vomeronasal ... Almost all known membrane receptors are transmembrane protein s. A certain cell membrane can have several membrane receptors with various amounts on its surface. A certain receptor may also exist at varying concentrations on different membrane surfaces, depending on the membrane and cell function. Since ... Complex Is Necessary for Stabilization of Acetylcholine Receptor Clusters at Neuromuscular Junctions and Formation of the Synaptic Basement Membrane journal The Journal of Cell Biology year 2001 volume ... more details
mono 003 ch1d1.pdf The KIR Gene Cluster, NIH Bookshelf, PDF MeshName killer cell immunoglobulin like receptor Immune receptors Category Immunoglobulin like receptors Category receptors receptor stub de Killer Cell Immunoglobulin like Receptor ...Killer cell immunoglobulin like receptors KIRs , are a family of cell surface proteins found on important cells of the immune system called natural killer cell natural killer NK cells . They regulate the killing function of these cells by interacting with Major histocompatibility complex MHC class I MHC class I molecules , which are expressed on all cell types. This interaction allows them to detect virus virally infected cells or tumor cell s that have a characteristic low level of Class I MHC on their surface. Most KIRs are inhibitory, meaning that their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the ability to activate cells. ref cite journal author Vilches C, Parham P title KIR diverse, rapidly evolving receptors of innate and adaptive immunity journal Annu Rev Immunol volume 20 issue pages 217 51 year 2002 pmid 11861603 doi 10.1146 annurev.immunol.20.092501.134942 ref KIR molecules are highly Polymorphism biology polymorphic , meaning their gene sequences differ greatly between individuals, so that different individuals possess different arrays repertoires of KIR genes. ref cite journal author Uhrberg M title The KIR gene family life in the fast lane of evolution journal Eur J Immunol volume 35 issue 1 pages 10 5 year 2005 pmid 15580655 doi 10.1002 eji.200425743 ref Genes two domains, long cytoplasmic tail KIR2DL1 , KIR2DL2 , KIR2DL3 , KIR2DL4 , KIR2DL5A , KIR2DL5B , two domains, short cytoplasmic tail KIR2DS1 , KIR2DS2 , KIR2DS3 , KIR2DS4 , KIR2DS5 three domains, long cytoplasmic tail KIR3DL1 , KIR3DL2 , KIR3DL3 three domains, short cytoplasmic tail KIR3DS1 See also Leukocyte immunoglobulin like receptors ... more details
PBB geneid 10002 The photoreceptor cell specific nuclear receptor PNR , also known as NR2E3 nuclear receptor subfamily 2, group E, member 3 , is a protein that in humans is encoded by the NR2E3 gene . ref ..., Taniwaki M, Yasuda K, Umesono K title Identification of a photoreceptor cell specific nuclear receptor ... receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate journal Nat. Genet ... J, Ferraz F, Yu Umesono R, Munnich A, Kaplan J title The photoreceptor cell specific nuclear receptor .... Cell Genet. volume 89 issue 3 4 pages 279 80 year 2000 pmid 10965145 doi 10.1159 000015635 cite journal author Gerber S, Rozet JM, Takezawa SI, et al. title The photoreceptor cell specific nuclear receptor ... 10.1073 pnas.96.9.4814 pmc 21774 ref PNR is a member of the nuclear receptor super family of intracellular ... AF, Stone EM, Sheffield VC, Jacobson SG title The nuclear receptor NR2E3 plays a role in human retinal ... author Chen F, Figueroa DJ, Marmorstein AD, et al. title Retina specific nuclear receptor A potential ... AV, et al. title Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate. journal Nat. Genet. volume 24 issue 2 pages 127 31 year 2000 pmid ... cone cell proliferation due to lack of a functional NR2E3 causes retinal dysplasia and degeneration ... receptor NR2E3 plays a role in human retinal photoreceptor differentiation and degeneration journal .... title Photoreceptor specific nuclear receptor NR2E3 functions as a transcriptional activator in rod ... of photoreceptor specific nuclear receptor NR2E3 in rod photoreceptors of fetal human retina journal ... The rod photoreceptor specific nuclear receptor Nr2e3 represses transcription of multiple cone specific ... specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription ..., in vivo, and site specific phosphorylation dynamics in signaling networks journal Cell volume 127 ... nuclear receptor NR2E3 causes autosomal dominant retinitis pigmentosa journal Am. J. Hum. Genet. volume ... more details
wiktionary Receptor may refer to Cellular Sensory receptor , in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse Molecular Receptor biochemistry , in biochemistry, a protein molecule that receives and responds to a neurotransmitter, or other substance Special cases of receptors in biochemistry Cell surface receptor , a receptor on the outer surface of a cell membrane, that takes part in communication between the cell and the outside world Nuclear receptor , a receptor found within cells that is responsible for sensing steroid and thyroid hormones and certain other molecules Immune receptor , a receptor that occurs on the surface of immunocytes and binds to antigens Telecommunication Receiver radio , a device for the reception of electromagnetic signals disambig ar ca Receptor fr R cepteur id Reseptor it Recettore lt Receptorius nl Receptor oc Receptor ro Receptor ru sl Receptor fi Reseptori zh ... more details
that possess a distinct T cellreceptor TCR on their surface. A majority of T cells have a T cell ... T cellreceptor through V D J recombination . As the TCR locus begins to be rearranged the DN1 ... of CD4 T cells occurs through the engagement of both the T cellreceptor and CD28 on the T cell by the major ... of CD28 co stimulation , T cellreceptor signalling alone results in anergy . The signalling pathways downstream from both CD28 and the T cellreceptor involve many proteins. The first signal is provided by binding of the T cellreceptor to a short peptide presented by the major histocompatibility ..., as self peptides will not usually be presented with suitable co stimulation. The T cellreceptor exists as a complex of several proteins. The actual T cellreceptor is composed of two separate peptide chains, which are produced from the independent T cellreceptor alpha and beta TCR and TCR genes ...Infobox Anatomy Name T cell Latin lymphocytus T GraySubject GrayPage Image Red White Blood cells.jpg Caption Scanning electron micrograph of T lymphocyte right , a platelet center and a red blood cell ... 2 00 04.1.02007 T cells or T lymphocytes belong to a group of white blood cell s known as lymphocyte s, and play a central role in cell mediated immunity . They can be distinguished from other lymphocytes, such as B cell s and natural killer cell s NK cells , by the presence of a T cellreceptor TCR on the cell surface. They are called T cells because they mature in the thymus , and thus .... Types Helper T helper cell T sub H sub cells assist other white blood cells in immunologic processes, including maturation of B cell s into plasma cell s and memory B cell s, and activation of cytotoxic ... cell s APCs . Once activated, they divide rapidly and secrete small proteins called cytokine s that regulate ... subtypes, including T helper cell T sub H sub 1 , Th2 T sub H sub 2 , Th3 T sub H sub 3 , Th17 T sub ... and T cell polarization in autoimmune inflammation publisher Jci.org date 2007 05 01 accessdate ... more details
wiktionary cellCell s may refer to TOCright Science and technology Cell biology , the functional basic unit of life Cell EDA , a term used in an electronic circuit design schematics Cell geometry , a three dimensional element, part of a higher dimensional object Cell journal Cell journal , a scientific journal Cell microprocessor , a microprocessor architecture developed by Sony, Toshiba, and IBM Cell, the basic unit of Flash memory Principles of operation Flash memory Cell or mobile phone , a phone connected to a cellular network Cell, area of radio coverage in a cellular network Cell, a basic unit of a cellular automaton Electrochemical cell , a device used to convert chemical energy to electrical energy Galvanic cell or Voltaic cell, a particular kind of electrochemical cell Music Cell music , a small rhythmic and melodic design that can be isolated, or can make up one part of a thematic context. Fiction Cell comics , a Marvel comic book character Cell, a List of Dragon Ball characters Cell character in Dragon Ball media Cell novel Cell novel , a 2006 horror novel by Stephen King Cell, the name of two different Web television series, from 2008 and 2010 respectively. Society Prison cell , a room used to hold people in prisons Cell, a unit of a clandestine cell system , a penetration resistant form of a secret or outlawed organization Cell, a group of people in a cell group , a form of Christian church organization. Religion Cell, a room or hut in which a monk or nun lives. See also The Cell disambiguation Cellular disambiguation CEL disambiguation disambiguation cs Cell cy Cell da Celle de Cell es C lula desambiguaci n eo elo apartigilo fr Cell gl C lula hom nimos ko it Cell he nl Cel ja no Celle andre betydninger pl Cell pt Cell ro Celul ru simple Cell disambiguation sk Bunka rozli ovacia str nka sr sh elija su S l fi Solu t smennyssivu sv Cell olika betydelser th ... more details
Unreferenced stub auto yes date December 2009 Infobox Anatomy Name PAGENAME Latin endocrinocytus S GraySubject GrayPage Image Caption Image2 Caption2 Precursor System Artery Vein Nerve Lymph MeshName MeshNumber Code Terminologia Histologica TH H3.04.02.0.00037 S cells are cells which release secretin , found in the jejunum and duodenum . They are stimulated by a drop in pH to 4 or below in the small intestine s lumen. The released secretin will increase the secretion of HCO sub 3 sub sup sup into the lumen, via the pancreas . S cells are also one of the main producers of cyclosamatin . Gastrointestinal physiology Human cell types derived primarily from endoderm DEFAULTSORT S Cell Category Human cells Category Digestive system Cell biology stub ru S sv S cell ... more details
Intracellular receptors are receptor biochemistry receptor s located inside the cell biology cell rather than on its cell membrane . Examples are the class of nuclear receptor s located in the cell nucleus and the IP3 receptor IP sub 3 sub receptor located on the endoplasmic reticulum . The ligand s that bind to them are usually intracellular second messenger s like inositol trisphosphate IP sub 3 sub and extracellular lipophilicity lipophilic hormone s like steroid hormone s. Some intracrine peptide hormone s also have intracellular receptors. Members This list is mirrored on receptor biochemistry and nuclear receptor please update all simultaneously Transcription factors Steroid hormone receptor Sex hormone receptor s sex hormone s Estrogen receptor and Androgen receptor one type Vitamin D receptor vitamin D , one type Glucocorticoid receptor glucocorticoid s, one type Mineralocorticoid receptor mineralocorticoids , one type Thyroid hormone receptor and Retinoic acid receptor vitamin A and related compounds Peroxisome proliferator activated receptor s PPARs, , and Retinoid X receptor Farnesoid X receptor Liver X receptor Pregnane X receptor Constitutive androstane receptor Various Sigma 1 receptor Sigma sub 1 sub neuroactive steroid neurosteroids IP3 receptor IP sub 3 sub receptor inositol triphosphate , IP sub 3 sub See also Receptor biochemistry Receptor Steroid hormone External links http www.nuclear receptor.com Nuclear Receptor journal homepage http nrr.georgetown.edu NRR nrrhome.htm Nuclear receptor resource at Georgetown University http www.nursa.org Nuclear receptor signalling atlas NURSA, open access journal Transcription factors Cell signaling Category Intracellular receptors Intracellular receptors it Recettore intracellulare zh ... more details
About Infobox film name The Cell image Thecellposter.jpg caption Original film poster director Tarsem ... million gross 104,155,843 The Cell is a 2000 science fiction psychological thriller film directed by Tarsem Singh , and starring Jennifer Lopez , Vince Vaughn and Vincent D Onofrio . Plot The cell is the structural ... page xc ref Stargher s victim is imprisoned in a prison cellcell in the form of a glass enclosure ... to take care of an advanced water pump, which he used to fill the cell with water . Novak discovers ... Dean Norris as Cole Artistic influences Some of the scenes in The Cell are inspired by works ... Cite web url http www.imdb.com title tt0209958 trivia title IMDB The Cell ref The scene where the Special ... Pavilion in Barcelona, Spain. Reception Critical reaction to The Cell has been mixed, with a score of 45 on Rotten Tomatoes based on 143 reviews. ref http www.rottentomatoes.com m the cell 2000 The Cell Movie Reviews, Pictures Rotten Tomatoes ref Roger Ebert gave the film four stars out ... apps pbcs.dll article?AID 20000818 REVIEWS 8180303 1023 The Cell rogerebert.com Reviews ref ... ref James Berardinelli gave the film three stars out of four, writing The Cell becomes the first ... an ordinary child into an inhuman monster. There are no easy answers, and The Cell doesn t pretend ... who are up to the challenge, it s worth spending time in The Cell . ref http www.reelviews.net php review template.php?identifier 975 Cell, The A movie review by James Berardinelli ref Conversely ... &mdash in flames. The Cell serves up some of the most gruesomely misogyny misogynistic imagery ... movies capsules 19239 CELL.html The Cell Capsule by Jonathan Rosenbaum From the Chicago ... The Cell 2 A sequel was released Direct to video direct to DVD on June 16, 2009. The story centers ... External links IMDb title 0209958 Amg title 195764 mojo title cell Rotten tomatoes 13516 The Cell Tarsem Singh DEFAULTSORT Cell Category 2000 films Category 2000s science fiction films Category 2000s ... more details
An immune receptor or immunologic receptor is a Receptor biochemistry receptor , usually on a cell membrane , which binds to a substance for example, a cytokine and causes a response in the immune system . Types The main receptors in the immune system are pattern recognition receptors PRRs , Toll like receptor s TLRs , killer activated receptor killer activated and killer inhibitor receptor s KARs and KIRs , complement receptor s, Fc receptors , B cellreceptor s and T cellreceptor s. ref name Immunology20Unless Lippincott s Illustrated Reviews Immunology. Paperback 384 pages. Publisher Lippincott Williams & Wilkins July 1, 2007 . Language English. ISBN 0781795435. ISBN 978 0781795432. Page 20 ref class wikitable Comparison Receptor Bind to ref name Immunology20Unless Function ref name Immunology20Unless align left pattern recognition receptors PRRs br e.g. Toll like receptor TLRs , NOD like receptor NLRs pathogen associated molecular pattern s PAMP Mediate cytokine production inflammation destroying pathogen killer activated receptor killer activated and killer inhibitor receptor s KARs and KIRs Avails NK cells to identify abnormal host cells KAR or inhibit inappropriate host cell destruction KIR complement receptor s complement proteins on e.g. microbes Allow phagocytic and B cells to recognize microbes and immune complexes Fc receptors epitope antibody complexes Stimulate phagocytosis B cellreceptor s epitope s B cell differentiation into plasma cells and proliferation T cellreceptor s linear epitopes bound to major histocompatibility complex MHC Activate T cells Cytokine receptor s cytokine s regulation and co ordination of immune responses See also antigen templates at bottom References references External links MeshName immunologic receptor Transmembrane receptors Immune receptors Category Immune system nl Immuunreceptor ar ... more details
DISPLAYTITLE D sub 2 sub like receptor The D sub 2 sub like receptors are a subfamily of dopamine receptor s that bind the endogenous neurotransmitter dopamine . The D sub 2 sub like subfamily consists of three G protein coupled receptor s which are coupled to Gi alpha subunit G sub i sub G sub o sub and mediate IPSP inhibitory neurotransmission , including D2 receptor D sub 2 sub , D3 receptor D sub 3 sub , and D4 receptor D sub 4 sub . For more information, please see the respective main articles of the individual subtypes Main D2 receptor Main D3 receptor Main D4 receptor See also D1 like receptor D sub 1 sub like receptor References Reflist 2 Unreferenced date February 2010 G protein coupled receptors Cell signaling Dopaminergics Category G protein coupled receptors Category Signal transduction Category Cell signaling transmembranereceptor stub ... more details
DISPLAYTITLE D sub 1 sub like receptor The D sub 1 sub like receptors are a subfamily of dopamine receptor s that bind the endogenous neurotransmitter dopamine . The D sub 1 sub like subfamily consists of two G protein coupled receptor s which are coupled to G s alpha G sub s sub and mediate EPSP excitatory neurotransmission , including D1 receptor D sub 1 sub and D5 receptor D sub 5 sub . For more information, please see the respective main articles of the individual subtypes Main D1 receptor Main D5 receptor See also D2 like receptor D sub 2 sub like receptor References Reflist 2 Unreferenced date February 2010 G protein coupled receptors Cell signaling Dopaminergics Category G protein coupled receptors Category Signal transduction Category Cell signaling transmembranereceptor stub ... more details
DISPLAYTITLE 5 HT sub 1 sub receptor The 5 HT sub 1 sub receptors are a subfamily of 5 HT receptor s that bind the endogenous neurotransmitter serotonin 5 hydroxytryptamine, 5 HT . ref name pmid7938165 cite journal author Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP title International Union of Pharmacology classification of receptors for 5 hydroxytryptamine Serotonin journal Pharmacol. Rev. volume 46 issue 2 pages 157 203 year 1994 pmid 7938165 doi issn url http pharmrev.aspetjournals.org cgi content abstract 46 2 157 ref The 5 HT sub 1 sub subfamily consists of five G protein coupled receptor s GPCRs that are coupled to Gi alpha subunit G sub i sub G sub o sub and mediate IPSP inhibitory neurotransmission , including 5 HT1A receptor 5 HT sub 1A sub , 5 HT1B receptor 5 HT sub 1B sub , 5 HT1D receptor 5 HT sub 1D sub , 5 HT1E receptor 5 HT sub 1E sub , and 5 HT1F receptor 5 HT sub 1F sub . There is no 5 HT sub 1C sub receptor, as it was reclassified as the 5 HT2C receptor 5 HT sub 2C sub receptor . For more information, please see the respective main articles of the individual subtypes Main 5 HT1A receptor Main 5 HT1B receptor Main 5 HT1D receptor Main 5 HT1E receptor Main 5 HT1F receptor See also 5 HT2 receptor 5 HT sub 2 sub receptor References reflist G protein coupled receptors Cell signaling Serotonergics Category G protein coupled receptors Category Signal transduction Category Cell signaling hu 5 HT1 receptor ru 5 HT1 sr 5 HT1 receptor ... more details
Unreferenced stub auto yes date December 2009 Orphan date December 2009 The somatotropin receptor , or growth hormone receptor , is a member of the cytokine receptor superfamily. One growth hormone molecule binds to one Receptor biochemistry receptor and then recruits a second receptor to form a protein dimer dimer through which Cell signaling signalling occurs. Growth hormone has a Gaussian function bell shaped dose response curve because high concentrations actually prevent dimerization of the receptors and prevent signalling. DEFAULTSORT Somatotropin Receptor Category Transmembrane receptors Biochemistry stub ... more details
P2 receptor may refer to P2Y receptors P2X receptors P is for purinergic, P2 refers to ATP receptors, as opposed to P1 adenosine adenosine receptor s. P2X receptors are ATP activated channels that allows the passage of ions across cell membranes. P2Y receptors are ATP activated G protein coupled receptor s GPCRs that initiate an intracellular chain of reactions. Long comment to avoid being listed on short pages Category G protein coupled receptors biochemistry stub ... more details
protein Name IL3RA interleukin 3 receptor, alpha caption image width HGNCid 6012 Symbol IL3RA AltSymbols CD123 EntrezGene OMIM 308385 RefSeq UniProt PDB ECnumber Chromosome X Arm p Band 22.3 LocusSupplementaryData protein Name interleukin 3 receptor, Y Chromosomal caption image width HGNCid 6012 Symbol IL3RA AltSymbols IL3RY, IL3RAY EntrezGene 3563 OMIM 430000 RefSeq UniProt PDB ECnumber Chromosome Y Arm p Band 11.3 LocusSupplementaryData The interleukin 3 receptor also known as CD123 antigen is a molecule found on cells which helps transmit the signal of interleukin 3 , a soluble cytokine important in the immune system . The gene coding for the receptor is located in the pseudoautosomal region of the X chromosome X and Y chromosome s. The receptor belongs to the type I cytokine receptor family and is a heterodimer with a unique alpha chain paired with the common beta beta c or CDw131 subunit. The gene for the alpha subunit is 40 kilobase s long and has 12 exon s. The receptor, found on pluripotent progenitor cells, induces tyrosine phosphorylation within the cell and promotes proliferation and differentiation within the hematopoietic cell lines. External links MeshName Interleukin 3 Receptor Cytokine receptors Category Cytokine receptors immunology stub sr Interleukin 3 receptor ... more details
Image Signal transduction pathways.svg thumb 400px Signal transduction. Cytokine receptor at center left. Cytokine receptor s are Receptor biochemistry receptor s that bind cytokine s. ref name ... receptor s, whose members have certain conserved motifs in their extracellular amino acid domain. The IL 2 receptor belongs to this chain, whose chain common to several other cytokines deficiency ... II cytokine receptor s, whose members are receptors mainly for interferon s. Immunoglobulin superfamily ... of the vertebrate body Tumor necrosis factor receptor family , whose members share a cysteine rich ... and CD30 , besides the ligands on which the family is named TNF . Chemokine receptor s, two of which ... beta receptors Comparison class wikitable Type Examples Structure Mechanism type I cytokine receptor Type 1 interleukin receptors Erythropoietin receptor GM CSF receptor G CSF receptor growth hormone receptor prolactin receptor Oncostatin M receptor Leukemia inhibitory factor receptor rowspan 2 Certain ... transduction pathways type II cytokine receptor Type II interleukin receptors interferon alpha beta receptor interferon gamma receptor Many members of the immunoglobulin superfamily Interleukin 1 receptor Colony stimulating factor 1 receptor CSF1 CD117 C kit receptor Interleukin 18 receptor Share structural homology biology homology with immunoglobulins antibody antibodies , cell adhesion molecule s, and even some cytokines. Tumor necrosis factor receptor family CD27 CD30 CD40 CD120 Lymphotoxin beta receptor cysteine rich common extracellular binding domain chemokine receptor s Interleukin 8 receptor CCR1 CXCR4 MCAF receptor NAP 2 receptor 7TM Receptor Seven transmembrane helix G protein coupled TGF beta receptors TGF beta receptor 1 TGF beta receptor 2 Solubility Cytokine receptors ... Cytokine receptors Category Cytokine receptors membrane protein stub receptor stub cs Cytokinov receptor it Recettori accoppiati a chinasi sr Citokinski receptor sv Cytokinreceptor ... more details
DISPLAYTITLE 5 HT sub 2 sub receptor The 5 HT sub 2 sub receptors are a subfamily of 5 HT receptor s that bind the endogenous neurotransmitter serotonin 5 hydroxytryptamine, 5 HT . ref name pmid7938165 cite journal author Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP title International Union of Pharmacology classification of receptors for 5 hydroxytryptamine Serotonin journal Pharmacol. Rev. volume 46 issue 2 pages 157 203 year 1994 pmid 7938165 doi url http pharmrev.aspetjournals.org cgi content abstract 46 2 157 ref The 5 HT sub 2 sub subfamily consists of three G protein coupled receptor s GPCRs which are coupled to Gq protein G sub q sub G sub 11 sub and mediate EPSP excitatory neurotransmission ref name pmid8788498 cite journal author Eison AS, Mullins UL title Regulation of central 5 HT2A receptors a review of in vivo studies journal Behavioural Brain Research volume 73 issue 1 2 pages 177 81 year 1996 pmid 8788498 doi 10.1016 0166 4328 96 00092 7 url ref , including 5 HT2A receptor 5 HT sub 2A sub , 5 HT2B receptor 5 HT sub 2B sub , and 5 HT2C receptor 5 HT sub 2C sub . For more information, please see the respective main articles of the individual subtypes Main 5 HT2A receptor Main 5 HT2B receptor Main 5 HT2C receptor See also 5 HT1 receptor 5 HT sub 1 sub receptor References reflist G protein coupled receptors Cell signaling Serotonergics Category G protein coupled receptors Category Signal transduction Category Cell signaling hu 5HT2 receptor ru 5 HT2 sr 5 HT2 receptor ... more details
Other uses Receptor disambiguation Technical date May 2008 In the field of biochemistry , a receptor is a molecule most often found on the surface of a Cell biology cell , which receives chemical signals originating externally from the cell. Through binding to a receptor, these signals direct a cell ... are protein molecules, embedded in either the plasma membrane cell surface receptor s or the cytoplasm or cell nucleus nucleus nuclear receptor s of a cell, to which one or more specific kinds of signal transduction signaling molecules may attach. A molecule which binds attaches to a receptor is called ... compared to the much more common types of receptors that cross the cell membrane. An example of a receptor ... and KIRs , complement receptor s, Fc receptors , B cellreceptor s and T cellreceptor s. ref name ... Transcription factors g2 DEFAULTSORT Receptor Biochemistry Category Cell biology Category Cell ... , a hormone , a pharmaceutical drug, or a toxin. Numerous receptor types are found within a typical cell and each type is linked to a specific biochemical pathway. Furthermore each type of receptor recognizes and binds only certain ligand shapes in analogy to a lock and key where the lock represents the receptor and the key, its ligand . Hence the selective binding of specific a ligand to its receptor activates or inhibits a specific biochemical pathway. Ligand binding stabilizes a certain receptor conformational change conformation the three dimensional shape of the receptor ... to some sort of cellular response. However, some ligands e.g. Receptor antagonist antagonists ... receptor.svg thumb right Transmembrane receptor E extracellular space I intracellular space P plasma ... categories peripheral membrane protein s transmembrane protein s G protein coupled receptor s Composed ... receptor and related nicotinicoid receptors journal J. Biol. Chem. volume 279 issue 19 pages ... at the interface between the subunits. receptor tyrosine kinase Functional receptors are homodimers ... more details
H3 antagonist H sub 3 sub receptor antagonists ABT 239 Ciproxifan Clobenpropit Thioperamide histamine H4 receptor H sub 4 sub gi subunit G sub i sub mediate mast cell chemotaxis . ref name ...The histamine receptors are a class of G protein coupled receptor s with histamine as their endogenous ligand . ref name pmid9311023 cite journal author Hill SJ, Ganellin CR, Timmerman H, Schwartz JC, Shankley NP, Young JM, Schunack W, Levi R, Haas HL title International Union of Pharmacology. XIII. Classification of histamine receptors journal Pharmacol. Rev. volume 49 issue 3 pages 253 78 year 1997 pmid 9311023 doi url http pharmrev.aspetjournals.org cgi content abstract 49 3 253 ref There are four known histamine receptors histamine H1 receptor H sub 1 sub receptor histamine H2 receptor H sub 2 sub receptor histamine H3 receptor H sub 3 sub receptor histamine H4 receptor H sub 4 sub receptor Comparison class wikitable Histamine receptors Receptor Mechanism Function Antagonists histamine H1 receptor H sub 1 sub Gq subunit G sub q sub ileum contraction modulate circadian cycle itching systemic ... H sub 1 sub receptor antagonist s Diphenhydramine Loratadine Cetirizine Fexofenadine histamine H2 receptor ... of gastric acid secretion Smooth muscle relaxation Inhibit antibody synthesis, T cell proliferation and cytokine production H2 antagonist H sub 2 sub receptor antagonist s Ranitidine Cimetidine Famotidine Nizatidine histamine H3 receptor H sub 3 sub gi subunit G sub i sub Decrease Acetylcholine ... H sub 4 sub receptor mediates chemotaxis and calcium mobilization of mast cells journal J. Pharmacol ... Histamine antagonist H4 receptor antagonists H sub 4 sub receptor antagonists Thioperamide JNJ 7777120 ... are 7 transmembrane g protein coupled receptor s, H sub 1 sub and H sub 2 sub are quite ... macromoleculeinsights.com histaminerec.php The Histamine Receptor MeshName Histamine Receptor G protein ... pl Receptory histaminowe pt Receptor de histamina sr Histaminski receptor sv Histaminreceptor ta ... more details
ref A phasic receptor is a sensory receptor that adapts rapidly to a stimulus. The response of the cell ...In a sensory system , a sensory receptor is a sensory nerve ending ref http www.encyclopedia.com doc ... environment of an organism . In response to stimuli the sensory receptor initiates sensory transduction by creating graded potential s or action potential s in the same cell or in an adjacent one ... Functions The sensory receptors involved in taste and smell contain receptor biochemistry receptor molecules that bind to specific chemicals. Odor receptor s in olfactory receptor neuron s, for example ..., photoreceptor cell s contain specialized proteins such as rhodopsin to transduction physiology ... fire action potentials when their membranes are physically stretched. The sensory receptor functions .... The stimulus modality to which a sensory receptor responds is determined by the sensory receptor s adequate stimulus . The sensory receptor responds to its stimulus modality by initiating sensory transduction. This may be accomplished by a net shift in the initial states of a receptor see a picture ... http www.bio balance.com Graphics.htm . Classification by adequate stimulus A sensory receptor ... to the osmolarity of fluids such as in the hypothalamus Photoreceptor cell Photoreceptor s respond ... receptors can be classified by location Cutaneous receptor s are sensory receptors found in the dermis or Epidermis skin epidermis . ref http medical dictionary.thefreedictionary.com Cutaneous receptor ... skin epidermis . Encapsulated receptor s consist of the remaining types of cutaneous receptors. Encapsulation exists for specialized functioning. by rate of adaptation A tonic receptor is a sensory receptor that adapts slowly to a stimulus ref name caspar http caspar.bgsu.edu courses Glossary.htm ... intensity and rate. ref name frank An example of a phasic receptor is the Pacinian corpuscle ... also Portal Neuroscience Sense Sensory neuron Proprioception Receptor theory References Reflist External ... more details
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