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Encyclopedia results for TATA binding protein

TATA binding protein





Encyclopedia results for TATA binding protein

  1. TATA-binding protein

    PBB geneid 6908 The TATA binding protein TBP is a general transcription factor that binds specifically to a DNA sequence called the TATA box . This DNA sequence is found about 25 base pair s upstream of the transcription ... Gene TBP TATA box binding protein url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... II , and RNA polymerase III . Interactions TATA binding protein has been shown to Protein protein ... contact with TATA box binding protein journal Mol. Cell. Biol. volume 14 issue 9 pages 6021 9 year ... Transcription factor IIA derepresses TATA binding protein TBP associated factor inhibition of TBP ... containing TATA binding protein, Sp1 and cAMP response element binding protein binding protein CBP p300 ... terminal arm mediate TATA binding protein interaction and transcriptional repression journal Proc ... p53 binds to the TATA binding protein and represses transcription journal Proc. Natl. Acad. Sci. U.S.A. ... F, Brady JN, Piatigorsky J title Pax 6 interactions with TATA box binding protein and retinoblastoma ... Interactions between the retinoid X receptor and a conserved region of the TATA binding protein mediate ... kinase activity of TATA binding protein associated factor TAFII250 journal Mol. Cell. Biol ... TATA Box Binding Protein FactorBook TBP PDB Gallery geneid 6908 Transcription factors g4 DEFAULTSORT Tata Binding Protein Category Proteins Category Genes Category Transcription factors cs TATA vazebn protein da TATA bindende protein es Prote na de uni n a TATA it Tata Binding Protein ja TATA pt Prote na de liga o TATA sv TATA bindande protein vi Protein li n k t h p TATA ... have TATA boxes. Therefore, TBP is probably not the only protein involved in positioning RNA polymerase ... in the N terminus of the protein. This region modulates the DNA binding activity of the C terminus ... . Binding of TFIID to the TATA box in the promotor biology promoter region of the gene initiates the recruitment ... binding protein, transcription factor IIB, and coactivators journal J. Biol. Chem. volume 270 issue ...   more details



  1. Binding protein

    A binding protein is any protein that acts as an agent to Molecular binding bind two or more molecules together. Examples include DNA binding protein Single strand binding protein Telomere binding protein RNA binding protein Poly A binding protein Nuclear cap binding protein complex CREB binding protein Calcium binding protein Calcium binding protein 1 S100 calcium binding protein A1 TATA binding protein Actin binding protein Penicillin binding proteins Retinol binding protein Retinol binding protein 4 EP300 Binding immunoglobulin protein Odorant binding protein Lipopolysaccharide binding protein C4b binding protein Rap GTP binding protein Calmodulin binding proteins Iron binding proteins Thyroxine binding proteins Folate binding protein Sterol regulatory element binding protein GTP binding protein Retinaldehyde binding protein 1 Ccaat enhancer binding proteins Androgen binding protein Maltose binding protein Phosphatidylethanolamine binding protein 1 Syntaxin binding protein 3 Insulin like growth factor binding protein Methyl CpG binding domain protein 2 Growth hormone binding protein Vitamin D binding protein Syntaxin binding protein 2 Oxysterol binding protein E3 binding protein Iron responsive element binding protein Polypyrimidine tract binding protein Fatty acid binding protein Myosin binding protein C, cardiac CPE binding protein Category Proteins biochem stub ...   more details



  1. Maltose-binding protein

    Maltose Binding Protein MBP is a part of the maltose maltodextrin system of Escherichia coli , which is responsible for the uptake and efficient catabolism of maltodextrins. It is a complex regulatory and transport system involving many protein s and protein complexes. MBP has an approximate molecular mass of 42.5 kilodaltons. Use MBP is used to increase the solubility of recombinant protein s expressed in E. coli . In these systems, the protein of interest is often expressed as a MBP fusion protein , preventing aggregation of the protein of interest. The mechanism by which MBP increases solubility is not well understood. In addition, MBP can itself be used as an affinity tag for purification of recombinant proteins. The fusion protein binds to amylose columns while all other proteins flow through. The MBP protein fusion can be purified by eluting the column with maltose. Once the fusion protein is obtained in purified form, the protein of interest X is often cleaved from MBP with a specific protease . Protein X can then be separated from MBP by ion exchange chromatography. See also Fluorescent glucose biosensors Glutathione S transferase External links http www.bio.mtu.edu campbell purifica.htm N Terminal Fusion of Target Protein to Maltose Binding Protein at Michigan Technological University MeshName maltose binding protein http www.nature.com nprot journal v2 n2 full nprot.2007.50.html Generic protocol for the expression and purification of recombinant proteins in Escherichia coli using a combinatorial His6 maltose binding protein fusion tag Category Proteins protein stub ...   more details



  1. Poly(A)-binding protein

    Image Poly A binding protein.png thumb Poly A RNA Binding Protein PABP, PDB 1CVJ Poly A binding protein PAB or PABP ref name pmid15630022 cite journal author Kahvejian A, Svitkin YV, Sukarieh R, M Boutchou MN, Sonenberg N title Mammalian poly A binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms journal Genes Dev. volume 19 issue 1 pages 104 13 year 2005 month January pmid 15630022 pmc 540229 doi 10.1101 gad.1262905 url http www.genesdev.org cgi pmidlookup?view long&pmid 15630022 ref is a RNA binding protein which binds to the poly A tail of mRNA . ref MeshName Poly A Binding Proteins ref The poly A tail is located on the 3 end of mRNA. The nuclear ... . Expression and binding The expression of mammalian Poly A binding protein is regulated at the translational ... Region UTR an A rich sequence which binds Poly A binding protein. This leads to repression of translation The cytosolic isoform of eukaryotes Poly A binding protein binds to the initiation factor ... cap on the 5 end of mRNA. This binding forms the characteristic loop structure of eukaryotic protein synthesis. Poly A binding protein interacting proteins in the cytosol compete for the eIF 4G binding sites. Poly A binding protein has also been shown to interact with a termination factor eRF3 Rotavirus ... binding protein NSP3 Rotavirus NSP3 interacts with Eukaryotic initiation factor eIF4GI and evicts the poly A binding protein from Eukaryotic initiation factor eIF4F . And NSP3A, by taking the place of PABP on Eukaryotic initiation factor eIF4GI , is responsible for the shut off of cellular protein synthesis ... Piron first1 M last2 Vende last3 Cohen last4 Poncet title Rotavirus RNA binding protein NSP3 interacts with eIF4GI and evicts the poly A binding protein from eIF4F volume 17 issue 19 pages 5811 21 journal ... M, Galloway DA title Cytoplasmic Poly A Binding Proteins Regulate Telomerase Activity and Cell Growth ... PABPC5 References Reflist RNA binding proteins Post transcriptional modification Category RNA binding ...   more details



  1. Pheromone binding protein

    Orphan date February 2009 Image PBP1.png thumb right 300px Pheromone binding proteins PBPs of insect s are small helix helical protein s postulated to contribute to the specificity of the insect s olfactory system by binding components of the natural pheromone mixtures. Although our understanding of the biochemical mechanisms of chemoreception in insects has greatly improved after the discovery of olfactory receptors and in spite of the significant amount of experimental information available to date for PBPs, the precise role of these protein s is still unknown. Category Entomology protein stub ...   more details



  1. Polypyrimidine tract-binding protein

    protein Name PTBP1 polypyrimidine tract binding protein 1 caption image width HGNCid 9583 Symbol PTBP1 AltSymbols PTB EntrezGene 5725 OMIM 600693 RefSeq NM 002819 UniProt P26599 PDB ECnumber Chromosome 19 Arm p Band 13.3 LocusSupplementaryData protein Name PTBP2 polypyrimidine tract binding protein 2 caption image width HGNCid 17662 Symbol PTBP2 AltSymbols EntrezGene 58155 OMIM 608449 RefSeq NM 021190 UniProt Q9UKA9 PDB ECnumber Chromosome 1 Arm p Band 21.3 LocusSupplementaryData 22.1 Polypyrimidine tract binding protein is an RNA binding protein , also known as PTB or hnRNP I. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3 end processing, mRNA stability and RNA localization. ref name pmid9382788 cite journal author Valc rcel J, Gebauer F title Post transcriptional regulation the dawn of PTB journal Curr. Biol. volume 7 issue 11 pages R705 8 year 1997 month November pmid 9382788 doi 10.1016 S0960 9822 06 00361 7 url ref See also Polypyrimidine tract References reflist External links MeshName polypyrimidine tract binding protein biochem stub RNA binding proteins ...   more details



  1. RNA-binding protein

    RNA binding proteins are proteins that bind to RNA . ref MeshName RNA Binding Proteins ref They bind to either double strand or single strand RNA s through RNA recognition motif RRM . RNA binding proteins often abbreviated as RBP may regulate the translation biology translation of RNA , and post transcriptional events, such as RNA splicing and editing. They are cytoplasm ic and cell nucleus nuclear proteins. However, since most mature RNA is exported from the nucleus relatively quickly, most RBPs in the nucleus exist as complexes of protein and Precursor mRNA pre mRNA called heterogeneous ribonucleoprotein particle s hnRNPs . Examples Some examples include translation initiation factor s that bind RNA, polyA binding protein s, snRNP s, ADAR , etc. External links http starbase.sysu.edu.cn starBase database a database for decoding binding sites of RNA binding proteins RBPs from CLIP Seq HITS CLIP, PAR CLIP, iCLIP data. http rbpdb.ccbr.utoronto.ca RBPDB database a database of RNA binding proteins. References reflist RNA binding proteins Ribonucleoproteins Category Cell biology Category RNA binding proteins Cell biology stub it RNA binding protein ...   more details



  1. DNA damage-binding protein

    protein Name damage specific DNA binding protein 1, 127kDa caption image width HGNCid 2717 Symbol DDB1 AltSymbols XPE EntrezGene 1642 OMIM 600045 RefSeq NM 001923 UniProt Q16531 PDB ECnumber Chromosome 11 Arm q Band 12 LocusSupplementaryData q13 protein Name damage specific DNA binding protein 2, 48kDa caption image width HGNCid 2718 Symbol DDB2 AltSymbols DBB, UV DDB2, FLJ34321 EntrezGene 1643 OMIM 600811 RefSeq NM 000107 UniProt Q92466 PDB ECnumber Chromosome 11 Arm p Band 12 LocusSupplementaryData p11 DNA damage binding protein is a protein complex that is responsible for repair of UV damaged DNA . ref name pmid8530102 cite journal author Dualan R, Brody T, Keeney S, Nichols AF, Admon A, Linn S title Chromosomal localization and cDNA cloning of the genes DDB1 and DDB2 for the p127 and p48 subunits of a human damage specific DNA binding protein journal Genomics volume 29 issue 1 pages 62 9 year 1996 month Feb pmid 8530102 pmc doi 10.1006 geno.1995.1215 ref This complex is composed of two protein subunits, a large subunit DDB1 and a small subunit DDB2 . This complex functions in nucleotide excision repair . References Reflist protein stub ...   more details



  1. RNA-binding protein database

    Orphan date April 2011 infobox biodatabase title RBPDB logo File Database.png description RNA binding protein RNA binding specificities. scope organism center University of Toronto laboratory Department of Molecular Genetics, author Kate B Cook pmid Cook & al. 2011 ref name pmid21036867 released 2010 standard format url http rbpdb.ccbr.utoronto.ca download webservice sql sparql webapp standalone license versioning frequency curation bookmark version RNA Binding Protein DataBase RBPDB is a database of experimental observations of RNA binding protein RNA binding sites. ref name pmid21036867 cite journal quotes yes last Cook first Kate B authorlink coauthors Kazan Hilal, Zuberi Khalid, Morris Quaid, Hughes Timothy R year 2011 month Jan title RBPDB a database of RNA binding specificities journal Nucleic Acids Res. volume 39 issue Database issue pages D301 8 publisher location England issn pmid 21036867 doi 10.1093 nar gkq1069 bibcode oclc id url pmc 3013675 language eng format accessdate laysummary laysource laydate quote ref See also RNA binding protein References references External links http rbpdb.ccbr.utoronto.ca . Category Biological databases Category RNA binding proteins Category RNA Category Proteins Biodatabase stub ...   more details



  1. Growth hormone-binding protein

    protein Name growth hormone receptor caption image width HGNCid 4263 Symbol GHR AltSymbols EntrezGene 2690 OMIM 600946 RefSeq NM 000163 UniProt P10912 PDB ECnumber Chromosome 5 Arm p Band 13 LocusSupplementaryData p12 No footnotes article date November 2011 Growth hormone binding protein is a carrier protein for growth hormone . It is coded by the same gene as growth hormone receptor . Low levels of Growth Hormone binding protein may indicate a growth hormone receptor problem, and thus a growth hormone insensitivity, rather than a growth hormone deficiency. Normal serum levels of growth hormone Binding Protein 3 may rule out growth hormone insensitivities, like those seen in en.wikipedia.org wiki Laron syndrome Larson syndrome. External links MeshName somatotropin binding protein cite journal pages 814 6 doi 10.1210 jcem 65 4 814 title Absence of the Plasma Growth Hormone Binding Protein in Laron Type Dwarfism year 1987 last1 Baumann first1 Gerhard last2 Shaw first2 Melissa A. last3 Winter first3 Robert J. journal Journal of Clinical Endocrinology & Metabolism volume 65 issue 4 pmid 3654924 Carrier proteins biochemistry stub ...   more details



  1. Androgen-binding protein

    protein Name Androgen binding protein, Sex hormone binding globulin caption image width HGNCid 10839 Symbol SHBG AltSymbols ABP EntrezGene 6462 OMIM 182205 RefSeq NM 001040 UniProt P04278 PDB ECnumber Chromosome 17 Arm p Band 13 LocusSupplementaryData p12 Androgen binding protein ABP is a glycoprotein beta globulin produced by the Sertoli cells in the seminiferous tubules of the testis that binds specifically to testosterone T , dihydrotestosterone DHT , and 17 beta estradiol . Because ABP binds to T and DHT, these hormones are made less lipophilic and become concentrated within the luminal fluid of the seminiferous tubules. The higher levels of these hormones enable spermatogenesis in the seminiferous tubules and sperm maturation in the epididymis . ABP has the same amino acid sequence as sex hormone binding globulin SHBG the difference is the site of production and the addition of different sugar moieties. ABP contains 403 amino acids, resulting in a molecular weight of 44,533. Its gene is located on chromosome 17 . ABP s production is regulated under influence of Follicle stimulating hormone FSH on Sertoli cell, enhanced by insulin , retinol , and testosterone . ABP may also be secreted in other organs for instance, mice produce a saliva ry ABP. See also Sex hormone binding globulin SHBG References Ensembl ENSG00000129214 External links MeshName Androgen Binding Protein Carrier proteins Category Glycoproteins de Androgen bindendes Protein pt Prote na ligadora de andr genos ...   more details



  1. Kinase binding protein CGI-121

    Orphan date July 2011 Infobox protein family Symbol CGI 121 Name CGI 121 image PDB 1zd0 EBI.jpg width caption crystal structure of pfu 542154 conserved hypothetical protein Pfam PF08617 Pfam clan InterPro IPR013926 SMART PROSITE MEROPS SCOP 1zd0 TCDB OPM family OPM protein CAZy CDD In molecular biology, the kinase binding protein CGI 121 family of proteins includes the kinase binding protein CGI 121 and its Homology biology homologues . CGI 121 has been shown to Molecular binding bind to the p53 related protein kinase PRPK . ref name pmid12659830 cite journal author Miyoshi A, Kito K, Aramoto T, Abe Y, Kobayashi N, Ueda N title Identification of CGI 121, a novel PRPK p53 related protein kinase binding protein journal Biochem. Biophys. Res. Commun. volume 303 issue 2 pages 399 405 year 2003 month April pmid 12659830 doi 10.1016 S0006 291X 03 00333 4 url ref CGI 121 is part of a conserved protein complex, KEOPS. The KEOPS Protein complex complex is involved in telomere uncapping and telomere elongation. ref name pmid16564010 cite journal author Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D title A genome wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator journal Cell volume 124 issue 6 pages 1155 68 year 2006 month March pmid 16564010 doi 10.1016 j.cell.2005.12.044 url ref Interestingly, this family of proteins also include archaeal homology biology homologues . References reflist InterPro content IPR013926 DEFAULTSORT Kinase Binding Protein Cgi 121 Category Protein domains ...   more details



  1. Guanylate-binding protein

    Orphan date December 2011 Infobox protein family Symbol GBP Name Guanylate binding protein, N terminal domain image PDB 1dg3 EBI.jpg width caption structure of human guanylate binding protein 1 in nucleotide free form Pfam PF02263 Pfam clan CL0023 InterPro IPR015894 SMART PROSITE MEROPS SCOP 1dg3 TCDB OPM family OPM protein CAZy CDD Infobox protein family Symbol GBP C Name Guanylate binding protein, C terminal domain image PDB 1dg3 EBI.jpg width caption structure of human guanylate binding protein 1 in nucleotide free form Pfam PF02841 Pfam clan InterPro IPR003191 SMART PROSITE MEROPS SCOP 1dg3 TCDB OPM family OPM protein CAZy CDD In molecular biology, the guanylate binding protein protein family family is a family of GTPases that is Regulation of gene expression induced by Interferon gamma interferon IFN gamma . GTPases induced by IFN gamma Interferon inducible GTPase are key to the protective immunity medical immunity against microbe microbial and virus viral pathogen s. These GTPases are classified into three groups the small 47 KD immunity related GTPases IRGs , the Mx proteins MX1 , MX2 , and the large 65 to 67 kd GTPases. Guanylate binding protein s GBP fall into the last class. In humans, there are seven GBPs hGBP1 7 . ref name pmid17266443 cite journal author Tripal P, Bauer M, Naschberger E, Mortinger T, Hohenadl C, Cornali E, Thurau M, Sturzl M title Unique features of different members of the human guanylate binding protein family journal J. Interferon Cytokine Res ... Prakash B, Praefcke GJ, Renault L, Wittinghofer A, Herrmann C. Structure of human guanylate binding protein 1 representing a unique class of GTP binding proteins. Nature. 2000 Feb 3 403 6769 567 71 ... N, Gessner R, Kremmer E, Gessner A, Sturzl M title Human guanylate binding protein 1 is a secreted ... Structurally, GBP1 hGBP1 consists of two domains a compact globular N terminal protein domain domain ... InterPro content IPR015894 Category Protein domains ...   more details



  1. Calcium-binding protein

    Calcium binding proteins are protein s that participate in calcium signaling calcium cell signalling pathways by binding to Ca sup 2 sup . The most ubiquitous Ca sup 2 sup sensing protein, found in all eukaryotic organisms including yeasts , is calmodulin . Intracellular storage and release of Ca sup 2 sup from the sarcoplasmic reticulum is associated with the high capacity, low affinity calcium binding protein calsequestrin . ref Siegel, George Ed. . Basic neurochemistry molecular, cellular and medical aspects . Lippincott Williams and Wilkins 1999 ISBN 0 397 51820 X ref With their role in signal transduction, calcium binding proteins contribute to all aspects of the cell s functioning, from homeostasis to learning and memory. For example, the neuron specific calexcitin has been found to have an excitatory effect on neuron s, and interacts with proteins that control the firing state of neurons, such as the voltage dependent potassium channel . ref cite journal author Nelson T, Cavallaro S, Yi C, McPhie D, Schreurs B, Gusev P, Favit A, Zohar O, Kim J, Beushausen S, Ascoli G, Olds J, Neve R, Alkon D title Calexcitin a signaling protein that binds calcium and Guanosine triphosphate GTP , inhibits potassium channels , and enhances membrane excitability journal Proceedings of the National Academy of Sciences PNAS volume 93 issue 24 pages 13808 13 year 1996 pmid 8943017 doi 10.1073 pnas.93.24.13808 pmc 19433 ref See also Vitamin D dependent calcium binding protein Wikipedia MeSH D12.776 MeSH D12.776.157.125 calcium binding proteins References Reflist External links MeshName Calcium Binding Proteins Note calcium binding proteins have now been seen in the dietary supplement market such as Apoaequorin http www.prevagen.com Prevagen . Carrier proteins Calcium binding proteins Category Proteins Category Calcium signaling ja ...   more details



  1. Odorant-binding protein

    Pfam box Symbol PBP GOBP Name Pheromone general odorant binding protein image width caption Pfam PF01395 InterPro IPR006170 SMART Prosite SCOP 1c3z TCDB OPM family OPM protein PDB protein Name OBP2A odorant binding protein 2A caption image 3QME.pdb.jpg width HGNCid 23380 Symbol OBP2A AltSymbols hOBPIIa, OBP EntrezGene 29991 OMIM 164320 RefSeq NM 014582 UniProt Q9NY56 PDB ECnumber Chromosome 9 Arm q Band 34 LocusSupplementaryData protein Name odorant binding protein 2B caption Crystal Structure of an Anopheles gambiae Odorant binding Protein AgamOBP22a with Bound Odorant Cyclohexanone image width HGNCid 23381 Symbol OBP2B AltSymbols hOBPIIb EntrezGene 29989 OMIM 604606 RefSeq NM 014581 UniProt Q9NPH6 PDB ECnumber Chromosome 9 Arm q Band 34 LocusSupplementaryData Odorant binding proteins are abundant small soluble proteins secreted in the nasal mucus of many animal species and in the sensillar lymph of chemosensory sensilla of insects . The olfactory receptors of terrestrial animals exist in an water aqueous environment , yet detect odorants that are primarily hydrophobic . The aqueous solubility of hydrophobic odorants is greatly enhanced via odorant binding proteins, which exist in the extracellular fluid surrounding the odorant receptors. ref name PUB00003450 cite journal author Prestwich GD, Vogt RG, Lerner MR title Odorant binding protein subfamilies associate with distinct classes of olfactory receptor neurons in insects journal J. Neurobiol. volume 22 issue 1 pages 74 84 year 1991 pmid 2010751 ref This family is composed of pheromone binding proteins PBP , which are male specific and associate with pheromone sensitive neurons and general odorant binding proteins GOBP . These proteins were initially identified on the basis of their ability to bind with moderate affinity ... of PNP Oxidase from S. cerevisiae ref References reflist Carrier proteins DEFAULTSORT Odorant Binding Protein Category Olfaction Category Proteins it Odorant binding protein ...   more details



  1. Acyl-CoA-binding protein

    Infobox protein family Symbol ACBP Name ACBP image PDB 1hb8 EBI.jpg width caption structure of bovine acyl coa binding protein in tetragonal crystal form Pfam PF00887 Pfam clan InterPro IPR000582 SMART PROSITE PDOC00686 MEROPS SCOP 1aca TCDB OPM family OPM protein CAZy CDD cd00435 In molecular biology, the Acyl CoA binding protein ACBP is a small 10 Kd protein that Molecular binding bind s medium and long ... cloning of the gene for the yeast homolog ACB of diazepam binding inhibitor endozepine acyl CoA binding protein journal Proc. Natl. Acad. Sci. U.S.A. volume 89 issue 23 pages 11287 91 year 1992 ... title Evolution of the acyl CoA binding protein ACBP journal Biochem. J. volume 392 issue Pt 2 pages ... M, Rose TM, Faergeman NJ, Knudsen J title Evolution of the acyl CoA binding protein ACBP journal ... and the protein. ref name pmid11491287 cite journal author van Aalten DM, Milne KG, Zou JY, Kleywegt GJ, Bergfors T, Ferguson MA, Knudsen J, Jones TA title Binding site differences revealed by crystal structures of Plasmodium falciparum and bovine acyl CoA binding protein journal J. Mol. Biol. volume ... Binding molecular binding inhibitor DBI or endozepine EP because of its ability to displace ... receptor . It is therefore possible that this protein also acts as a neuropeptide to modulate the action ... E, Guidotti A title Diazepam binding inhibitor DBI a peptide with multiple biological actions journal ... url ref ACBP is a Conservation genetics highly conserved protein of about 90 amino acids that is found ... ACBP occurs as a completely independent protein, intact ACB protein domain domains have been identified in a number of large, multifunctional protein proteins in a variety of eukaryote eukaryotic species ... shape with a highly exposed acyl CoA binding site. The ligand biochemistry ligand is bound through specific interactions with residues on the protein, most notably several conserved sequence conserved positive charges that Protein protein interaction interact with the phosphate group on the adenosine ...   more details



  1. Plasma protein binding

    unbound is the fraction that is actually active and may be excreted. Protein binding can ... of the altered protein binding Only the unbound fraction of the drug undergoes metabolism in the liver and other tissues. As the drug dissociates from the protein more and more drug undergoes metabolism ..., the quality of the plasma protein may affect how many drug binding sites there are on the protein ... of protein binding is most significant with drugs that are highly protein bound 95 and have ... http www.pubpk.org index.php?title Drug Protein Binding PubPK Drug Protein Binding Pharmacology Category ...A drug s efficiency may be affected by the degree to which it binds to the protein s within blood plasma ... for plasma protein, a proportion of the drug may become bound to plasma proteins, with the remainder being unbound. If the protein binding is reversible, then a chemical equilibrium will exist between the bound and unbound states, such that Protein drug Protein drug complex Notably, it is the unbound ... of plasma protein, and other drugs that bind to plasma proteins. Higher drug concentrations would lead to a higher fraction unbound, because the plasma protein would be saturated with drug and any excess drug would be unbound. If the amount of plasma protein is decreased such as in catabolism , malnutrition ..., assume that Drug A and Drug B are both protein bound drugs. If Drug A is given, it will bind to the plasma proteins in the blood. If Drug B is also given, it can displace Drug A from the protein ... on warfarin takes another drug that displaces warfarin from plasma protein, such as a sulfonamide antibiotic, it could result in an increased risk of bleeding. Plasma protein binding prediction software http www.q pharm.com products services admet plasma protein binding prediction Quantum Plasma Protein Binding http www.simulations plus.com Definitions.aspx?lID 65&pID 13 S Plasma Protein Binding http albumin.althotas.com Albumin binding prediction See also Pharmacokinetics Blood proteins ...   more details



  1. Single-strand binding protein

    Single stranded DNA binding protein , or SSB, binds to single stranded regions of deoxyribonucleic acid DNA to prevent premature Annealing biology Annealing annealing , to protect the single stranded DNA from being digested by nucleases, and to remove secondary structure from the DNA to allow other enzymes to function effectively upon it. Single stranded DNA is produced during all aspects of DNA metabolism replication, recombination and repair. As well as stabilizing this single stranded DNA, SSB proteins bind to and modulate the function of numerous proteins involved in all of these processes. SSB proteins have been identified in organisms from viruses to humans. While many phage and viral SSBs function as monomers and eukaryotes encode heterotrimeric RPA Replication Protein A , the best characterized SSB is that from the bacteria E. coli which, like most bacterial SSBs exists as a Tetrameric protein tetramer . Active E. coli SSB is composed of four identical 19 kDa subunits. Binding of single stranded DNA to the tetramer can occur in different modes , with SSB occupying different numbers of DNA bases depending on a number of factors, including salt concentration. For example, the SSB sub 65 sub binding mode, in which approximately 65 nucleotides of DNA wrap around the SSB tetramer and contact all four of its subunits, is favoured at high salt concentrations in vitro . At lower salt concentrations, the SSB sub 35 sub binding mode, in which about 35 nucleotides bind to only two ... binding modes in vivo . See also DNA replication DNA binding protein List of nucleic acid simulation software Nucleic acid simulations External links MeshName Single Stranded DNA Binding Proteins ... Proteins Category DNA binding substances protein stub cs SSB protein de Einzelstrang bindendes Protein es Prote nas SSB fr Prot ine de liaison l ADN simple brin gl SSB it Single strand binding protein ... binding protein zh DNA ...   more details



  1. Actin-binding protein

    binding proteins, including actinin, spectrin, dystrophin, utrophin and fimbrin, do this through the actin binding calponin homology domain. This is a list of actin binding protein s in alphabetical ... Gastrin Binding Protein Gelactins I IV Gelsolins Glucokinase H Harmonin b Hrp36 Hexokinase Hrp65 2 Hectochlorin HS1 actin binding protein Helicase II Hsp27 HIP1 Huntingtin Interacting protein 1 Hsp70 Histactophilin Hsp90 Histidine rich protein II Hsp100 I Inhibitor of apoptosis IAP Insertin Interaptin ... 2011 MAYP Mycalolide a macroglide drug Mayven Myelin basic protein N Naphthylphthalamic acid binding ... toxin Villin Vitamin D binding protein W Wiskott Aldrich Sydrome Protein Interacting Protein WIP Wiskott ...Actin binding proteins also known as ABP are proteins that bind to actin . ref name pmid12663865 cite journal author dos Remedios CG, Chhabra D, Kekic M, et al. title Actin binding proteins regulation ... Abp numbers p58gag.htm p58gag in The Encyclopaedia of Actin Binding Proteins and Drugs , op. cit ... ABP50 EF 1a Acan 125 Carmil Actin assembly inducing protein ActA Actibind Actin Actinfilin Actinogelin ... AIP1 Aldolase Angiogenin Anilin Annexins Aplyronine Archvillin Arginine kinase Arp2 3 protein Arp2 3 complex B Band 4.1 Band 4.9 Dematin b actinin b Cap73 Bifocal protein Bifocal Bistramide A BPAG1 ... CAP protein CAP Caltropin CH ILKBP CPb3 Cap100 Calvasculin Ciboulot Coactosin CAP23 CARMIL Acan125 Cingulin Cytovillin Ezrin CapZ CapZ Capping Protein a Catenin Cofilin protein CR16 CR16 Caldesmon protein CCT CCT Comitin Cytochalasins small molecules, not proteins Calicin Centuarin Coronin D ... Extracellular signal regulated kinases ERK ENC 1 ERM protein s ezrin , radixin , moesin , plus merlin protein merlin END3p Ezrin the E of ERM protein family F F17R Fodrin spectrin Fascin Formins ... K Kabiramide C Kaptin Kettin Kelch protein L Latrunculin Latrunculin L2 small molecule, not a protein 5 Lipoxygenase Limatin Lim Kinases Lim Proteins L plastin Lymphocyte Specific Protein 1 LSP1 ...   more details



  1. Lipopolysaccharide-binding protein

    PBB geneid 3929 Lipopolysaccharide binding protein is a protein that in humans is encoded by the LBP ... title The genes for the lipopolysaccharide binding protein LBP and the bactericidal permeability increasing protein BPI are encoded in the same region of human chromosome 20 journal Genomics volume ... roles of CD14 and lipopolysaccharide binding protein for activation of toll like receptor TLR 2 as well ... web title Entrez Gene LBP lipopolysaccharide binding protein url http www.ncbi.nlm.nih.gov sites ... binding protein has been shown to Protein protein interaction interact with CD14 , TLR2 , TLR4 and the co ... interaction of Mac 2 binding protein with immobilized CD14 journal J. Inflamm. volume 45 issue ... GW, et al. title Structure and function of lipopolysaccharide binding protein. journal Science volume ... LPS binding protein. LPS binding properties and effects on LPS mediated cell activation ... author Park CT, Wright SD title Plasma lipopolysaccharide binding protein is found associated with a particle ... cite journal author Nanbo A, Nishimura H, Nagasawa S title Lipopolysaccharide binding protein from ..., Au Young J, Lamping N, et al. title Similar organization of the lipopolysaccharide binding protein LBP and phospholipid transfer protein PLTP genes suggests a common gene family of lipid binding proteins ..., Snoek AM, et al. title Lipopolysaccharide binding protein and serum amyloid A secretion by human intestinal ... Lipopolysaccharide Binding Protein and Phospholipid Transfer Protein Release Lipopolysaccharides ... binding protein by respiratory type II epithelial cells implications for local defense to bacterial ... LPS Binding Protein in Neutralization of LPS and Enhancement of LPS Induced Activation of Mononuclear ... Kaden J, Zwerenz P, Lambrecht HG, Dostatni R title Lipopolysaccharide binding protein as a new and reliable ... of lipopolysaccharide LPS to LPS binding protein LBP residues 86 99 by using an Ala scanning library ... External links MeshName lipopolysaccharide binding protein NLM content TLR signaling pathway The PBB ...   more details



  1. CREB-binding protein

    transcriptional complex containing TATA binding protein, Sp1 and cAMP response element binding protein ...see also p300 CBP coactivator family PBB geneid 1387 CREB binding protein , also known as CREBBP or CBP ... of human CREB binding protein gene CREBBP to 16p13.2 p13.3 by fluorescence in situ hybridization ... CH3 and the interferon response binding domain IBiD . The CREB protein domains, KIX, TAZ1 and TAZ2 ... transcription factor s. First isolated as a nuclear protein that binds to cAMP response element binding ... domain. ref name entrez cite web title Entrez Gene CREBBP CREB binding protein url http www.ncbi.nlm.nih.gov ... binding protein has been shown to Protein protein interaction interact with div col colwidth 20em ... coauthors Engedal N, Slagsvold T, Saatcioglu F year 1998 month Nov. title CREB binding protein ... Mar. title CREB binding protein in androgen receptor mediated signaling journal PNAS Proc. Natl ... binding protein journal J. Biol. Chem. volume 275 issue 22 pages 16802 9 publisher location UNITED ... Sept. title CCAAT enhancer binding protein family members recruit the coactivator CREB binding protein ... F, Traber P G year 1999 month Mar. title CREB binding corrected protein interacts with the homeodomain ... kinase A pathway and cAMP responsive element binding protein in androgen receptor mediated transcription ... through activating transcription factor 1 but not cAMP response element binding protein journal ... propensity in the binding of the KIX domain of CREB binding protein by constitutive c Myb and inducible ... p53 recruitment of CREB binding protein mediated through phosphorylated CREB a novel pathway of tumor ... month Jul. title Histone binding protein RbAp48 interacts with a complex of CREB binding protein ... binding protein journal Mol. Cell. Biol. volume 21 issue 7 pages 2249 58 publisher location United ... of the homeodomain CCAAT displacement cut protein function by histone acetyltransferases p300 CREB binding ... protein binding protein CBP and p300 CBP associated factor P CAF results in reversible acetylation ...   more details



  1. Oxysterol-binding protein

    Pfam box Symbol Oxysterol BP Name Oxysterol binding protein image 1ZHT.png width caption Crystallographic structure of the oxysterol binding protein rainbow color cartoon, N terminus blue, C terminus red bound to 7 alpha hydroxycholesterol 7 hydroxycholesterol stick diagram, carbon white, oxygen red . ref name pmid16136145 PDB 1ZHT cite journal author Im YJ, Raychaudhuri S, Prinz WA, Hurley JH title Structural mechanism for sterol sensing and transport by OSBP related proteins journal Nature volume 437 issue 7055 pages 154 8 year 2005 month September pmid 16136145 pmc 1431608 doi 10.1038 nature03923 url ref Pfam PF01237 InterPro IPR000648 SMART PROSITE PDOC00774 SCOP TCDB OPM family 173 OPM protein 1zi7 PDB Oxysterol binding proteins are evolutionary related proteins involved with sterol synthesis and or its regulation ref name PUB00005653 cite journal author Bussey H, Fortin N, Jiang B, Brown JL, Sheraton J title A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein journal Yeast volume 10 issue 3 pages 341 353 year 1994 pmid 8017104 doi 10.1002 yea.320100307 ref . These include mammalian oxysterol binding protein OSBP , a protein of about 800 amino acid residues that binds a variety of oxysterols oxygenated derivatives of cholesterol yeast OSH1, a protein of 859 residues that also plays a role in ergosterol synthesis and yeast proteins HES1 and KES1, highly related proteins of 434 residues that seem to play a role in ergosterol synthesis ref Analysis of oxysterol binding protein homologue Kes1p function in regulation of Sec14p dependent protein transport from the yeast Golgi complex. Li X, Rivas MP, Fang M, Marchena J, Mehrotra B, Chaudhary A, Feng L, Prestwich GD, Bankaitis VA J Cell Biol 2002 157 63 77. PMID ... OSBPL2 OSBPL3 OSBPL5 OSBPL6 OSBPL7 OSBPL8 OSBPL9 Category Protein domains Category Peripheral membrane proteins InterPro content IPR000648 membrane protein stub ...   more details



  1. Folate-binding protein

    Folate binding protein FBP are proteins that bind folate , typically the folate receptor s and reduced folate carrier . ref name Kelemen2006 cite journal url http onlinelibrary.wiley.com doi 10.1002 ijc.21712 pdf title The role of folate receptor a in cancer development, progression and treatment Cause, consequence or innocent bystander? year 2006 doi 10.1002 ijc.21712 pmid 16453285 volume 119 issue 2 journal Int. J. Cancer pages 243 50 ref It can be a marker for ovarian cancer . ref cite journal url http cancerres.aacrjournals.org content 51 19 5329.short title Folate binding Protein Is a Marker for Ovarian Cancer year 1991 ref It can be measured to help in tumour classification to aid treatment. FBP is over expressed 20 80 fold in more than 90 of ovarian cancer ovarian and endometrial cancer s, as well as 20 50 of breast, lung, colorectal, and renal cell carcinomas. FBP has very limited tissue distribution and expression in non malignant tissue, making it a good immunotherapy target. ref http www.marketwatch.com story galena biopharma to present at the 10th annual biotechnology investor forum 2011 10 21 ref Alternative usage FBP can refer to protein s e.g. extracted from cow s milk used to do folic acid assays. ref http www.scrippslabs.com enzymes biochemicals folate binding protein ref References reflist Category Folates Category Membrane proteins biochem stub ...   more details



  1. Bacterial DNA binding protein

    Orphan date June 2011 Infobox protein family Symbol Bac DNA binding Name Bac DNA binding image PDB 1p51 EBI.jpg width caption anabaena hu dna cocrystal structure ahu6 Pfam PF00216 Pfam clan InterPro IPR000119 SMART PROSITE PDOC00044 MEROPS SCOP 1hue TCDB OPM family OPM protein CAZy CDD In molecular biology, bacterial DNA binding proteins are a family of small, usually Base chemistry basic protein s of about 90 residues that Molecular binding bind DNA and are known as histone like proteins. ref name pmid3118156 cite journal author Drlica K, Rouviere Yaniv J title Histonelike proteins of bacteria journal Microbiol. Rev. volume 51 issue 3 pages 301 19 year 1987 month September pmid 3118156 pmc 373113 doi url ref ref name pmid3047111 cite journal author Pettijohn DE title Histone like proteins and bacterial chromosome structure journal J. Biol. Chem. volume 263 issue 26 pages 12793 6 year 1988 month September pmid 3047111 doi url ref Examples include the HU protein in Escherichia coli is a protein dimer dimer of closely related alpha and beta chains and in other bacterium bacteria can be a dimer ... 6540370 doi 10.1038 310376a0 url ref The protein exists as a dimer and two beta arms function as the non specific binding site for bacteria l DNA. References reflist InterPro content IPR000119 DEFAULTSORT Bacterial Dna Binding Protien Category Protein domains ... like protein, a histone like protein, and an acyl carrier protein journal Proc. Natl. Acad. Sci ... a protein for all reasons journal Cell volume 55 issue 4 pages 545 54 year 1988 month November pmid 2972385 doi 10.1016 0092 8674 88 90213 9 url ref is found in enterobacteria and viral protein s include the African Swine Fever virus protein A104R or LMW5 AR . ref name pmid8464748 cite journal ... fever virus gene with similarity to bacterial DNA binding proteins, bacterial integration host factors ... I, Appelt K, Dijk J, White SW, Wilson KS title 3 A resolution structure of a protein with histone ...   more details



  1. GTP-binding protein regulators

    External links MeshName GTP Binding Protein Regulators Intracellular signaling peptides and proteins GTP binding protein regulators Category Proteins Category GTP binding protein regulators sr Regulatori ...   more details




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