The TPP thiazolium ring can be deprotonated at C2 to become an ylid. Image Thiaminepyrophosphate ...chembox verifiedrevid 450157910 ImageFile Thiamine diphosphate.png ImageSize 200px IUPACName 2 3 4 amino 2 methylpyrimidin 5 yl methyl 4 methyl 1,3 thiazol 3 ium 5 yl ethyl phosphono hydrogen phosphate IUPACName hidden yes OtherNames Thiamine diphosphate Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 10670483 UNII Ref fdacite correct FDA UNII Q57971654Y InChI 1 C12H17N4OS.ClH.H4O7P2 c1 8 11 3 4 17 18 7 16 8 6 10 5 14 9 2 15 12 10 13 1 8 2,3 7 9 4,5 6 h5,7,17H,3 4,6H2,1 2H3, H2,13,14,15 1H H2,1,2,3 H2,4,5,6 q 1 p 1 InChIKey NBSUTVXQOGUTJX REWHXWOFAB StdInChI Ref stdinchicite correct chemspider StdInChI 1S C12H17N4OS.ClH.H4O7P2 c1 8 11 3 4 17 18 7 16 8 6 10 5 14 9 2 15 12 10 13 1 8 2,3 7 9 4,5 6 h5,7,17H,3 4,6H2,1 2H3, H2,13,14,15 1H H2,1,2,3 H2,4,5,6 q 1 p 1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey NBSUTVXQOGUTJX UHFFFAOYSA M CASNo Ref cascite correct CAS CASNo 154 87 0 PubChem 1132 SMILES Cl .OP O O OP O O O.Cc2nc N c C n 1csc CCO c1C cn2 MeSHName Thiaminepyrophosphate Section2 Chembox Properties Formula C sub 12 sub H sub 19 sub N sub 4 sub O sub 7 sub P sub 2 sub S sup sup MolarMass 425.314382 g mol Appearance Density MeltingPt BoilingPt Section3 Chembox Hazards Solubility MainHazards FlashPt Autoignition Thiaminepyrophosphate TPP or ThPP , or thiamine diphosphate ThDP , is a thiamine vitamin B sub 1 sub Derivative chemistry derivative which is produced by the enzyme thiamine pyrophosphatase . Thiaminepyrophosphate ... its link with the peripheral nervous system disease Beriberi , which results from a deficiency of thiamine ..., which is in turn connected to a pyrophosphate diphosphate functional group . The part of TPP molecule ... Thiazoles Category Pyrimidines Category B vitamins de Thiaminpyrophosphat fa fr Thiaminepyrophosphate gl Pirofosfato de tiamina it Tiamina pirofosfato ja pl Pirofosforan tiaminy ... more details
phosphate derivatives are involved in many cellular processes. The best characterized form is thiaminepyrophosphate TPP , a coenzyme in the catabolism of sugars and amino acids . Thiamine is used ... ThMP , thiamine diphosphate ThDP , also sometimes called thiaminepyrophosphate TPP , thiamine triphosphate ... diphosphate The synthesis of thiamine diphosphate ThDP , also known as thiaminepyrophosphate ... 458360938 Name Thiamine chloride ImageFileL1 Thiamin.svg ImageFileL1 Ref chemboximage correct ?? ImageSizeL1 121 ImageNameL1 Kekul skeletal formula of the cation in thiamine ImageFileR1 Cl .svg ImageFileR1 Ref chemboximage correct ?? ImageSizeR1 61 ImageNameR1 Chloride ImageFile2 Thiamine 3D vdW.png ImageFile2 Ref chemboximage correct ?? ImageSize2 244 ImageName2 Spacefill model of thiamine of the cation in thiamine IUPACName 2 3 4 Amino 2 methyl pyrimidin 5 yl methyl 4 methyl thiazol ... 3 KEGG u08580 KEGG Ref keggcite changed kegg MeSHName Thiamine ChEBI Ref ebicite correct EBI ChEBI ... 300.81159583 g mol sup 1 sup Thiamine or thiamin or vitamin B sub 1 sub IPAc en icon a . m ... , TPP is also required in the first step of alcoholic fermentation . All living organisms use thiamine ... peripheral nervous polyneuritis and or cardiovascular system . Thiamine deficiency has a potentially ... 7 ref There is still much research devoted to elucidating the exact mechanisms by which thiamine deficiency leads to the specific symptoms observed see below . New thiamine phosphate derivatives ... P year 2007 title Discovery of a natural thiamine adenine nucleotide journal Nature Chem. Biol. volume 3 issue 4 pages 211 212 doi 10.1038 nchembio867 pmid 17334376 ref emphasizing the complexity of thiamine metabolism. Thiamine derivatives with improved pharmacokinetic s have been discovered and are to be considered more effective in alleviating the symptoms of thiamine deficiency and other thiamine ... , among others. Chemical properties Thiamine is a colorless chemical compound compound with a chemical ... more details
pyrophosphate Superphosphate Thiaminepyrophosphate Tooth Zinc pyrophosphate Div col end References ...Chembox verifiedrevid 444077628 ImageFile Pyrophosphate anion.png ImageSize 150px ImageFile1 Pyrophosphate 3D balls.png ImageSize1 150px ImageAlt1 ImageName1 Pyrophosphate anion IUPACName OtherNames Diphosphate Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 559142 InChI 1 H4O7P2 c1 8 2,3 7 9 4,5 6 h H2,1,2,3 H2,4,5,6 p 4 InChIKey XPPKVPWEQAFLFU XBHQNQODAI StdInChI Ref stdinchicite correct chemspider StdInChI 1S H4O7P2 c1 8 2,3 7 9 4,5 6 h H2,1,2,3 H2,4,5,6 p 4 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey XPPKVPWEQAFLFU UHFFFAOYSA J CASNo Ref cascite correct ?? CASNo PubChem 644102 DrugBank Ref drugbankcite correct drugbank DrugBank DB04160 ChEBI Ref ebicite correct EBI ChEBI 18361 SMILES O P O O OP O O O Section2 Chembox Properties .... Pyrophosphate is the first member of an entire series of polyphosphate s. The term pyrophosphate ... compound with inorganic phosphate as for dimethylallyl pyrophosphate . This bond is also referred to as a high energy phosphate bond. The synthesis of tetraethyl pyrophosphate was first described ... , pyrophosphate PP sub i sub is released. Pyrophosphorolysis is the reverse of the polymerization reaction in which pyrophosphate reacts with the 3 nucleotidemonophosphate NMP or dNMP , which is removed ... . The pyrophosphate anion has the structure P sub 2 sub O sub 7 sub sup 4&minus sup , and is an acid ..., hydrolysis reactions of simple polyphosphates such as pyrophosphate, linear triphosphate, Adenosine .... ref name Huebner cite journal author Huebner PWA, Milburn RM title Hydrolysis of pyrophosphate to orthophosphate ... Biochemistry Bone Calcium pyrophosphate Calcium pyrophosphate dihydrate deposition disease Catalysis ... pyrophosphate MeshName Pyrophosphates footer templates Phosphorus compounds categories Category ... Anions bg ca Pirofosfat de Diphosphate es Pirofosfato fa fr Pyrophosphate gl Pirofosfato ... more details
Infobox protein family Symbol Thia YuaJ Name Thia YuaJ image width caption Pfam PF09515 Pfam clan CL0315 InterPro IPR012651 SMART PROSITE MEROPS SCOP TCDB OPM family 275 OPM protein 3rlb CAZy CDD Members of this protein family have been assigned as thiamine membrane transporter protein transporter s by a phylogenomic analysis of families of genes regulated by the THI element, a broadly conserved sequence conserved RNA secondary structure element through which thiamine pyrophosphate TPP levels can Transcriptional regulation regulate transcription of many genes related to thiamine transport, salvage, and de novo biosynthesis . Species with this protein always lack the ThiBPQ ABC transporter. In some species e.g. Streptococcus mutans and Streptococcus pyogenes , yuaJ is the only THI regulated gene. Evidence from Bacillus cereus indicates thiamine uptake is coupled to proton Chromosomal translocation translocation . This family includes human solute transporters SLC19A1 , SLC19A2 and SLC19A3 . References reflist InterPro content IPR012651 Category Transmembrane transporters Category Protein families ... more details
Unreferenced stub auto yes date December 2009 Chembox verifiedrevid 424660305 ImageFile Farnesyl pyrophosphate.png ImageSize 220px ImageName Skeletal formula ImageFile1 Farnesyl pyrophosphate 3D balls.png ImageSize1 250px ImageName1 Ball and stick model IUPACName OtherNames Section1 Chembox Identifiers CASNo Ref cascite correct ?? CASNo 13058 04 3 PubChem 706 SMILES MeSHName farnesyl pyrophosphate Section2 Chembox Properties Formula C sub 15 sub H sub 28 sub O sub 7 sub P sub 2 sub MolarMass 382.326 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Farnesyl pyrophosphate FPP , also known as farnesyl diphosphate FDP , is an intermediate in the HMG CoA reductase pathway used by organisms in the biosynthesis of terpene s, terpenoid s, and sterol s. It is the immediate precursor of squalene via the enzyme squalene synthase , dehydrodolichol diphosphate a precursor of dolichol , and geranylgeranyl pyrophosphate GGPP . Biosynthesis Farnesyl pyrophosphate synthase a prenyl transferase catalyzes sequential condensation reactions of dimethylallyl pyrophosphate with 2 units of 3 isopentenyl pyrophosphate to form farnesyl pyrophosphate, as is shown in the following two steps Dimethylallyl pyrophosphate reacts with 3 isopentenyl pyrophosphate to form geranyl pyrophosphate Image Cholesterol Synthesis Reaction8.png Geranyl pyrophosphate then reacts with another molecule of 3 isopentenyl pyrophosphate to form farnesyl pyrophosphate Image Cholesterol Synthesis Reaction9.png Regulation The above reactions are inhibited by bisphosphonate s used for osteoporosis . Related compounds Farnesene Farnesol Geranyl pyrophosphate Geranylgeranyl pyrophosphate Cholesterol metabolism intermediates DEFAULTSORT Farnesyl Pyrophosphate Category Organophosphates Category Sesquiterpenes Biochem stub fa fi Farnesyylipyrofosfaatti zh ... more details
chembox verifiedrevid 403176984 ImageFile undecaprenyl pyrophosphate.png ImageSize 280px ImageName Skeletal formula of C55 isoprenyl pyrophosphate ImageFile1 C55 isoprenyl pyrophosphate 3D balls.png ImageSize1 280px ImageName1 Ball and stick model of C55 isoprenyl pyrophosphate IUPACName phosphono 2 E ,6 E ,10 E ,14 E ,18 E ,22 E ,26 E ,30 E ,34 E ,38 E 3,7,11,15,19,23,27,31,35,39,43 undecamethyltetratetraconta 2,6,10,14,18,22,26,30,34,38,42 undecaenyl hydrogen phosphate IUPACName hidden yes OtherNames C55 undecaprenyl pyrophosphate Undecaprenyl pyrophosphate Pyrophosphoryl undecaprenol Undecaisoprenyl pyrophosphate Undecaprenyl diphosphate Section1 Chembox Identifiers CASNo 31867 59 1 PubChem 5280604 SMILES CC CCC C C CC C C CC C C CC C C CC C C CC C C CC C C CC C C CC C C CC C C COP O O OP O O O C C C C C C C C C C C Section2 Chembox Properties C 55 H 92 O 7 P 2 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition C55 isoprenyl pyrophosphate undecaprenyl pyrophosphate is an essential molecule involved in construction of the bacterial peptidoglycan cell wall . organic compound stub microbiology stub Category Organophosphates Category Terpenes and terpenoids ... more details
enzyme Name thiamin kinase EC number 2.7.1.89 CAS number 62213 38 1 IUBMB EC number 2 7 1 89 GO code 0019165 image width caption In enzymology , a thiamine kinase EC number 2.7.1.89 is an enzyme that catalysis catalyzes the chemical reaction ATP thiamine math rightleftharpoons math ADP thiamine phosphate Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and thiamine , whereas its two product chemistry products are adenosine diphosphate ADP and thiamine phosphate . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with an alcohol group as acceptor. The systematic name of this enzyme class is ATP thiamine phosphotransferase . Other names in common use include thiamin kinase phosphorylating , thiamin phosphokinase , ATP thiamin phosphotransferase , and thiamin kinase . This enzyme participates in thiamine metabolism . References reflist 1 cite journal author Iwashima A, Nishino H, Nose Y date 1972 title Conversion of thiamine to thiamine monophosphate by cell free extracts of Escherichia coli journal Biochim. Biophys. Acta. volume 258 pages 333&ndash 6 pmid 4550803 issue 1 enzyme stub Category EC 2.7.1 Category Enzymes of unknown structure ... more details
Thiamine mono nitrate is a synthetic form of vitamin B1 . Allergic Reaction Health Concerns Liver Disease References University of Maryland Medical Center Vitamin B1 Journal of Nutrition Bioavailability for Rats of Thiamin in Whole Wheat and Thiamin Restored White Bread G. Ranhotra et al. May 1985 MedlinePlus Thiamine External link http www.livestrong.com article 313249 the side effects of thiamine mononitrate ixzz1iXetnLU1 Livestrong article Category Food additives ... more details
enzyme Name thiamin triphosphatase EC number 3.6.1.28 CAS number 9068 47 7 IUBMB EC number 3 6 1 28 GO code 0050333 image width caption protein Name thiamine triphosphatase caption image width HGNCid 18987 Symbol THTPA AltSymbols EntrezGene 79178 OMIM RefSeq NM 024328 UniProt Q9BU02 PDB ECnumber 3.6.1.28 Chromosome 14 Arm q Band 11.2 LocusSupplementaryData Thiamine triphosphatase is an enzyme involved in thiamine metabolism . It catalysis catalyzes the chemical reaction thiamine triphosphate H sub 2 sub O math rightleftharpoons math thiamine diphosphate phosphate This enzyme belongs to the family of acid anhydride hydrolase s, specifically those acting on phosphorus containing anhydrides. Its systematic name is thiamine triphosphate phosphohydrolase. Structural studies As of late 2007, only one tertiary structure structure has been solved for this class of enzymes, with the Protein Data Bank PDB accession code PDB link 2JMU . See also Thiamine diphosphate kinase References reflist 1 cite journal author Hashitani Y, Cooper JR date 1972 title The partial purification of thiamine triphosphatase from rat brain journal J. Biol. Chem. volume 247 pages 2117&ndash 9 pmid 4335862 issue 7 Acid anhydride hydrolases hydrolase stub Category EC 3.6.1 Category Enzymes of known structure ... more details
enzyme Name thiamin diphosphokinase EC number 2.7.6.2 CAS number 9026 24 8 IUBMB EC number 2 7 6 2 GO code 0004788 image width caption In enzymology , a thiamine diphosphokinase EC number 2.7.6.2 is an enzyme that catalysis catalyzes the chemical reaction ATP thiamine math rightleftharpoons math AMP thiamine diphosphate Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and thiamine , whereas its two product chemistry products are adenosine monophosphate AMP and thiamine diphosphate . This enzyme belongs to the family of transferase s, specifically those transferring two phosphorus containing groups diphosphotransferase s . The systematic name of this enzyme class is ATP thiamine diphosphotransferase . Other names in common use include thiamin kinase , thiamine pyrophosphokinase , ATP thiamin pyrophosphotransferase , thiamin pyrophosphokinase , thiamin pyrophosphotransferase , thiaminokinase , thiamin ATP pyrophosphotransferase , and TPTase . This enzyme participates in thiamine metabolism . Structural studies As of late 2007, 6 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1IG0 , PDB link 1IG3 , PDB link 2F17 , PDB link 2G9Z , PDB link 2HH9 , and PDB link 2OMK . References reflist 1 cite journal author Leuthardt F and Nielsen H date 1952 title Phosphorylation biologique de la thiamine journal Helv. Chim. Acta volume 35 issue 4 pages 1196&ndash 1209 doi 10.1002 hlca.19520350415 cite journal author Shimazono N, Mano Y, Tanaka R and Kajiro Y date Tokyo title Mechanism of transpyrophosphorylation with thiamine pyrophosphokinase journal J. volume Biochem. pages 959&ndash 961 cite journal author Steyn Parve EP date 1952 title Partial purification and properties of thiaminokinase from yeast journal Biochim. Biophys. Acta volume 8 pages 310&ndash 324 doi 10.1016 0006 3002 52 90046 2 pmid 14934742 Kinases Metabolism of vitamins, coenzymes, and cofactors ... more details
CRC Press ISBN 0 8493 8671 3 ref Sodium pyrophosphate is used as a buffering agent , an emulsifier ... s containing sodium pyrophosphate include chicken nugget s, marshmallows , pudding , crab meat, imitation ... powder s. In toothpaste and dental floss, sodium pyrophosphate acts as a Calculus dental tartar ... deposited on teeth . Sodium pyrophosphate is sometimes used in household detergent s to prevent ... , promoting algae growth. Calcium pyrophosphate is the crystal deposited in joints in the medical condition ... de Tetranatriumdiphosphat fa fr Pyrophosphate de sodium it Pirofosfato di ... more details
ref improve date March 2012 enzyme Name thiamin oxidase EC number 1.1.3.23 CAS number 96779 44 1 IUBMB EC number 1 1 3 23 GO code 0050423 image width caption In enzymology , a thiamine oxidase EC number 1.1.3.23 is an enzyme that catalysis catalyzes the chemical reaction thiamine 2 O sub 2 sub H sub 2 sub O math rightleftharpoons math thiamine acetic acid 2 H sub 2 sub O sub 2 sub The 3 substrate biochemistry substrates of this enzyme are thiamine , oxygen O sub 2 sub , and water H sub 2 sub O , whereas its two product chemistry products are thiamine acetic acid and hydrogen peroxide H sub 2 sub O sub 2 sub . This enzyme belongs to the family of oxidoreductase s, specifically those acting on the CH OH group of donor with oxygen as acceptor. The systematic name of this enzyme class is thiamine oxygen 5 oxidoreductase . Other names in common use include thiamin dehydrogenase , thiamine dehydrogenase , and thiamin oxygen 5 oxidoreductase . This enzyme participates in thiamine metabolism . It employs one cofactor biochemistry cofactor , FAD . References reflist 1 cite journal author Edmondson DE, Kenney WC, Singer TP date 1976 title Structural elucidation and properties of 8alpha N1 histidyl riboflavin the flavin component of thiamine dehydrogenase and beta cyclopiazonate oxidocyclase journal Biochemistry. volume 15 pages 2937&ndash 45 pmid 8076 doi 10.1021 bi00659a001 issue 14 cite journal author Gomez Moreno C, Edmondson DE date 1985 title Evidence for an aldehyde intermediate in the catalytic mechanism of thiamine oxidase journal Arch. Biochem. Biophys. volume 239 pages 46&ndash 52 pmid 2988447 doi 10.1016 0003 9861 85 90810 0 issue 1 cite journal author Neal RA date 1970 title Bacterial metabolism of thiamine. 3. Metabolism of thiamine to 3 2 methyl 4 amino 5 pyrimidylmethyl 4 methyl thiazole 5 acetic acid thiamine acetic acid by a flavoprotein isolated from a soil microorganism journal J. Biol. Chem. volume 245 pages 2599&ndash 604 pmid 4987737 issue 10 1.1 enzyme ... more details
chembox verifiedrevid 451189391 ImageFile IPP.png ImageSize 210px ImageName Skeletal formula of IPP ImageFile1 Isopentenyl pyrophosphate 3D balls.png ImageSize1 220px ImageName1 Ball and stick model of IPP IUPACName hydroxy 3 methylbut 3 enoxy phosphoryl oxyphosphonic acid OtherNames Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 13115335 InChI 1 C5H12O7P2 c1 5 2 3 4 11 14 9,10 12 13 6,7 8 h1,3 4H2,2H3, H,9,10 H2,6,7,8 p 3 InChIKey NUHSROFQTUXZQQ DFZHHIFOAI StdInChI Ref stdinchicite correct chemspider StdInChI 1S C5H12O7P2 c1 5 2 3 4 11 14 9,10 12 13 6,7 8 h1,3 4H2,2H3, H,9,10 H2,6,7,8 p 3 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey NUHSROFQTUXZQQ UHFFFAOYSA K CASNo Ref cascite correct ?? CASNo 358 71 4 PubChem 15983957 ChEBI Ref ebicite correct EBI ChEBI 128769 SMILES CC C CCOP O O OP O O O MeSHName isopentenyl pyrophosphate Section2 Chembox Properties Formula C sub 5 sub H sub 12 sub O sub 7 sub P sub 2 sub MolarMass 246.092 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Isopentenyl pyrophosphate IPP is an intermediate in the classical, HMG CoA reductase pathway used by organisms in the biosynthesis of terpene s and terpenoid s. IPP is formed from acetyl CoA via mevalonic acid . IPP can then be isomerized to dimethylallyl pyrophosphate by the enzyme isopentenyl pyrophosphate isomerase . Image Mevalonate pathway.png 350px thumb center Mevalonate pathway Image Sterol synthesis.svg thumb center 350px Simplified version of the steroid synthesis pathway with the intermediates isopentenyl pyrophosphate IPP , dimethylallyl pyrophosphate DMAPP , geranyl pyrophosphate GPP and squalene shown. Some intermediates are omitted. IPP can be synthesized via the alternative, non mevalonate pathway of isoprenoid biosynthesis instead, where it is formed from E 4 hydroxy 3 methyl but 2 enyl pyrophosphate HMB PP by the enzyme HMB PP reductase LytB, IspH . The non m ... more details
Chembox Watchedfields changed verifiedrevid 443835762 ImageFile Geranylgeranyl pyrophosphate.png ImageSize IUPACName OtherNames Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 394418 InChI 1 C20H36O7P2 c1 17 2 9 6 10 18 3 11 7 12 19 4 13 8 14 20 5 15 16 26 29 24,25 27 28 21,22 23 h9,11,13,15H,6 8,10,12,14,16H2,1 5H3, H,24,25 H2,21,22,23 b18 11 ,19 13 ,20 15 InChIKey OINNEUNVOZHBOX QIRCYJPOBR StdInChI Ref stdinchicite correct chemspider StdInChI 1S C20H36O7P2 c1 17 2 9 6 10 18 3 11 7 12 19 4 13 8 14 20 5 15 16 26 29 24,25 27 28 21,22 23 h9,11,13,15H,6 8,10,12,14,16H2,1 5H3, H,24,25 H2,21,22,23 b18 11 ,19 13 ,20 15 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey OINNEUNVOZHBOX QIRCYJPOSA N CASNo 6699 20 3 PubChem 447277 ChEBI Ref ebicite correct EBI ChEBI 48861 SMILES O P O O OP O O OC C C CC C C C CC C C C CC C C C C C MeSHName geranylgeranyl pyrophosphate Section2 Chembox Properties C 20 H 36 O 7 P 2 Appearance Density MeltingPt BoilingPt Section3 Chembox Hazards Solubility MainHazards FlashPt Autoignition Geranylgeranyl pyrophosphate is an intermediate in the HMG CoA reductase pathway used by organisms in the biosynthesis of terpene s and terpenoid s. ref http www.rpi.edu dept bcbp molbiochem MBWeb mb2 part1 cholesterol.htm Cholesterol Synthesis , Rensselaer Polytechnic Institute ref In plants it is also the precursor to carotenoid s, gibberellin s, tocopherol s, and chlorophyll s. It is also a precursor to geranylgeranylation geranylgeranylated proteins. Related compounds Geranylgeraniol Geranyl pyrophosphate Farnesyl pyrophosphate References reflist Cholesterol metabolism intermediates DEFAULTSORT Geranylgeranyl Pyrophosphate Category Organophosphates Category Diterpenes Biochem stub ja fi Geranyyligeranyylipyrofosfaatti ... more details
CCOP O O OP O O OP O O O MeSHName Thiamine triphosphate Section2 Chembox Properties Formula C sub 12 ... BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Thiamine triphosphate ... AF, Lakaye B, Gulyai IE, Czerniecki J, Coumans B, Wins P, Grisar T & Bettendorff L. 2003 Thiamine triphosphate and thiamine triphosphatase activities from bacteria to mammals. Cell Mol Life Sci 60 ... name Ref2 Matsuda T & Cooper JR. 1981 Thiamine as an integral component of brain synaptosomal membranes ... Ref1 ref name Ref3 Lakaye B, Wirtzfeld B, Wins P, Grisar T & Bettendorff L. 2004 Thiamine triphosphate ... or Leigh s disease have not been confirmed. ref name Ref4 Cooper JR, Itokawa Y & Pincus JH. 1969 Thiamine ..., suppression of the carbon source leads to the accumulation, of adenosine thiamine triphosphate AThTP ... B. & Bettendorff L. 2010 Thiamine triphosphate synthesis in the rat brain is mitochondrial and coupled ... 1 583.long ref In mammals , ThTP is hydrolyzed to ThDP by a specific thiamine triphosphatase . ref ... P., Grisar T. & Bettendorff L. 2002 Molecular characterization of a specific thiamine triphosphatase ... 2008 Structural basis for the catalytic mechanism of mammalian 25 kDa thiamine triphosphatase. J Biol ... be converted into ThDP by thiamine diphosphate kinase . History Thiamine triphosphate ThTP was chemically ... s yeast. ref Kiessling K. H. 1953 Thiamine triphosphate in baker s yeast Nature 172 1187 1188. ref .... 13b 251 252. ref and in plants germs, but not in seeds, where thiamine was essentially phosphorylation unphosphorylated . ref Yusa T. 1962 Studies on thiamine triphosphate II. Thiamine triphosphate ... thiamine derivatives using a paper chromatography paper chromatographic method, followed by oxidation ... that ThTP represents far less than 10 of total thiamine in animal tissues. ref Rindi G. & de Giuseppe L. 1961 A new chromatographic method for the determination of thiamine and its mono , di ... more details
Unreferenced stub auto yes date December 2009 Chembox Watchedfields changed verifiedrevid 443496302 ImageFile calcium pyrophosphate.png ImageSize 200px IUPACName Calcium diphosphate OtherNames Diphosphoric acid, calcium salt 1 2 Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 23034 UNII Ref fdacite correct FDA UNII X69NU20D19 InChI 1 2Ca.H4O7P2 c 1 8 2,3 7 9 4,5 6 h H2,1,2,3 H2,4,5,6 q2 2 p 4 InChIKey JUNWLZAGQLJVLR XBHQNQODAN StdInChI Ref stdinchicite correct chemspider StdInChI 1S 2Ca.H4O7P2 c 1 8 2,3 7 9 4,5 6 h H2,1,2,3 H2,4,5,6 q2 2 p 4 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey JUNWLZAGQLJVLR UHFFFAOYSA J CASNo 7790 76 3 CASNo Ref cascite correct CAS PubChem 24632 ChEBI Ref ebicite correct EBI ChEBI 32598 SMILES Ca 2 . Ca 2 . O P O O OP O O O MeSHName Calcium pyrophosphate Section2 Chembox Properties Formula Ca sub 2 sub O sub 7 sub P sub 2 sub MolarMass 254.053 g mol Appearance white powder ExactMass 253.837108 Density 3.09 g cm sup 3 sup MeltingPtC 1353 BoilingPt Solubility insoluble SolubleOther soluble in hydrochloric acid HCl , nitric acid s RefractIndex 1.585 Section3 Chembox Hazards EUIndex Not listed NFPA H 2 NFPA F 0 NFPA R 0 NFPA O FlashPt Non flammable Section8 Chembox Related OtherAnions Calcium phosphate OtherCations Magnesium pyrophosphate br Sodium pyrophosphate Calcium pyrophosphate Ca sub 2 sub O sub 7 sub P sub 2 sub is a chemical compound that can be formed by the reaction of pyrophosphoric acid and a calcium base or by strongly heating calcium phosphate or calcium ammonium phosphate. It is commonly used as a mild abrasive agent in toothpastes . Deposition of CPPD in articular joints causes an arthritis condition called pseudogout . See also Calcium pyrophosphate deposition disease Calcium compounds DEFAULTSORT Calcium Pyrophosphate Category Calcium compounds Category Pyrophosphates Inorganic compound stub ar ja sr Kalcijum pirofosfat zh ... more details
chembox verifiedrevid 402890942 Name Zinc pyrophosphate Reference ref name hand Citation last Lide first David R. author link last2 first2 author2 link publication date date year 1998 title Handbook of Chemistry and Physics edition 87 volume series publication place Boca Raton, FL place publisher CRC Press id isbn 0 8493 0594 2 doi oclc pages 4 96 url accessdate ref ImageFile Zinc pyrophosphate.png ImageSize ImageName Zinc pyrophosphate OtherNames Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 56393 PubChem 62641 InChI 1 H4O7P2.2Zn c1 8 2,3 7 9 4,5 6 h H2,1,2,3 H2,4,5,6 q 2 2 p 4 InChIKey OMSYGYSPFZQFFP XBHQNQODAA SMILES Zn 2 . Zn 2 . O P O O OP O O O StdInChI Ref stdinchicite correct chemspider StdInChI 1S H4O7P2.2Zn c1 8 2,3 7 9 4,5 6 h H2,1,2,3 H2,4,5,6 q 2 2 p 4 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey OMSYGYSPFZQFFP UHFFFAOYSA J CASNo 7446 26 6 Section2 Chembox Properties Formula Zn sub 2 sub P sub 2 sub O sub 7 sub MolarMass 304.72 g mol Appearance white crystalline powder Density 3.75 g cm sup 3 sup MeltingPt BoilingPt Solubility insoluble SolubleOther soluble in dilute acid s Section3 Chembox Structure CrystalStruct Section7 Chembox Hazards EUClass Zinc pyrophospate Zn sub 2 sub P sub 2 sub O sub 7 sub is an inorganic chemical compound . It is useful in gravimetric analysis of zinc. Zinc pyrophosphate is obtained by precipitating zinc as a phosphate, then heating over 1123 K. Fact date May 2009 References Reflist Zinc compounds Category Pyrophosphates Category Zinc compounds inorganic compound stub el fa ... more details
Chembox verifiedrevid 457790064 ImageFile Tetraethyl pyrophosphate.png ImageSize IUPACName tetraethyl diphosphate OtherNames Section1 Chembox Identifiers CASNo Ref cascite correct CAS CASNo 107 49 3 ChEMBL Ref ebicite correct EBI ChEMBL 293787 PubChem 7873 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 7585 SMILES O P OP O OCC OCC OCC OCC InChI 1 C8H20O7P2 c1 5 11 16 9,12 6 2 15 17 10,13 7 3 14 8 4 h5 8H2,1 4H3 InChIKey IDCBOTIENDVCBQ UHFFFAOYAI StdInChI Ref stdinchicite correct chemspider StdInChI 1S C8H20O7P2 c1 5 11 16 9,12 6 2 15 17 10,13 7 3 14 8 4 h5 8H2,1 4H3 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey IDCBOTIENDVCBQ UHFFFAOYSA N Section2 Chembox Properties C 8 H 20 O 7 P 2 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Tetraethyl pyrophosphate , abbreviated TEPP, is an organophosphate compound . It is used as a pesticide . This compound is a clear, colorless liquid. It is soluble in water, but hydrolyzes rapidly. ref Ullmann s doi 10.1002 14356007.a14 263 title Insect Control author Robert L. Metcalf ref It was first synthesized by Philippe de Clermont . This compound may be prepared by two equivalents of diethyl chlorophosphate with one equivalent of water in the presence of pyridine to scavenge the hydrogen chloride formed ref cite journal doi 10.1021 ja01191a104 journal J. Am. Chem. Soc. year 1948 last1 Toy first1 A. D. F. volume 70 issue 11 pages 3882 title The Preparation of Tetraethyl Pyrophosphate and Other Tetraalkyl Pyrophosphates ref File Synthesis of tetraethyl pyrophosphate.png 400px References References Category Pyrophosphates fa sr Tetraetil pirofosfat fi Tetraetyylipyrofosfaatti ... more details
enzyme Name thiamin diphosphate kinase EC number 2.7.4.15 CAS number 9075 79 0 IUBMB EC number 2 7 4 15 GO code 0050331 image width caption In enzymology , a thiamine diphosphate kinase is an enzyme involved in thiamine metabolism . It catalysis catalyzes the chemical reaction thiamine diphosphate ATP math rightleftharpoons math thiamine triphosphate ADP Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and thiamine diphosphate , whereas its two product chemistry products are adenosine diphosphate ADP and thiamine triphosphate . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with a phosphate group as acceptor. The systematic name of this enzyme class is ATP thiamine diphosphate phosphotransferase . Other names in common use include ATP thiamin diphosphate phosphotransferase , TDP kinase , thiamin diphosphate kinase , thiamin diphosphate phosphotransferase , thiamin pyrophosphate kinase , thiamine diphosphate kinase , and protein bound thiamin diphosphate ATP phosphoryltransferase . See also Thiamine triphosphatase References reflist 1 cite journal author Itokawa Y, Cooper JR date 1968 title The enzymatic synthesis of triphosphothiamin journal Biochim. Biophys. Acta. volume 158 pages 180&ndash 2 pmid 5661031 issue 1 cite journal author Kikuchi M and Ikawa T date Tokyo title Presence of an enzyme mediating transfer of phosphate from thiamine triphosphate to ADP in germinating maize journal Bot. volume Mag. pages 193&ndash 205 Kinases enzyme stub Category EC 2.7.4 Category Enzymes of unknown structure ... more details
enzyme Name thiamin phosphate kinase EC number 2.7.4.16 CAS number 9068 23 9 IUBMB EC number 2 7 4 16 GO code 0009030 image width caption In enzymology , a thiamine phosphate kinase EC number 2.7.4.16 is an enzyme that catalysis catalyzes the chemical reaction ATP thiamine phosphate math rightleftharpoons math ADP thiamine diphosphate Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and thiamine phosphate , whereas its two product chemistry products are adenosine diphosphate ADP and thiamine diphosphate . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with a phosphate group as acceptor. The systematic name of this enzyme class is ATP thiamine phosphate phosphotransferase . Other names in common use include thiamin monophosphate kinase , thiamin monophosphatase , and thiamin monophosphokinase . This enzyme participates in thiamine metabolism . Structural studies As of late 2007, only one tertiary structure structure has been solved for this class of enzymes, with the Protein Data Bank PDB accession code PDB link 1VQV . References reflist 1 cite journal author Nishino H date Tokyo title Biogenesis of cocarboxylase in Escherichia coli. Partial purification and some properties of thiamine monophosphate kinase journal J. volume Biochem. pages 1093&ndash 100 pmid 4567662 issue 5 enzyme stub Category EC 2.7.4 Category Enzymes of known structure ... more details
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