Infobox disease Name Thrombocytopenia Image Caption DiseasesDB 27522 ICD10 ICD10 D 69 6 d 65 , ICD10 ... 000586 eMedicineSubj eMedicineTopic MeshID D013921 Thrombocytopenia or thrombopenia is a relative ... of thrombocytopenia is a platelet count below 50,000 per microlitre. ref name pmid19118853 cite .... A person with thrombocytopenia may also complain of malaise, fatigue and general weakness with or without accompanying blood loss . In acquired thrombocytopenia, the patient s history may include the use ... can cause thrombocytopenia by direct infection of bone marrow megakaryocytes as well as immunological shortened platelet survival Hereditary syndromes Congenital amegakaryocytic thrombocytopenia CAMT Thrombocytopenia absent radius syndrome Fanconi anemia Bernard Soulier syndrome , associated with large platelets May Hegglin anomaly , the combination of thrombocytopenia, pale blue leuckocyte inclusions ... alloimmune thrombocytopenia NAITP Splenic sequestration of platelets due to hypersplenism Dengue fever ... thrombocytopenia ref name pmid11914001 cite journal pages 73 6 doi 10.1054 blre.2001.0188 title HIV related thrombocytopenia year 2002 last1 Scaradavou first1 A journal Blood Reviews volume 16 pmid 11914001 issue 1 ref Medication induced Thrombocytopenia inducing medications include Direct ... Thrombocytopenia symptoms, such as red dots near the bottom of the legs. ref cite journal pages 758 61 doi 10.1345 aph.1G384 title Pantoprazole Induced Thrombocytopenia year 2006 last1 Watson .... Heparin induced thrombocytopenia HIT is a classic example, in which the heparin antibody platelet ... destruction of the platelets is prevented. This may explain why severe thrombocytopenia is not a common feature of HIT. Abciximab induced thrombocytopenia. More extensive lists of thrombocytopenia inducing ... title Viper Agkistrodon halys blomhoffii Mamushi Bite with Remarkable Thrombocytopenia journal ... destruction. Thrombocytopenia in hospitalized alcoholics may be caused by splenomegaly ... more details
Wikify date March 2012 unreferenced date February 2010 Infobox disease Name Gestational thrombocytopenia Image Caption DiseasesDB ICD10 ICD10 O 99 1 o 94 ICD9 ICD9 649.3 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Gestational thrombocytopenia is a primarily benign condition of pregnancy of uncertain significance, believed to be related to idiopathic thrombocytopenic purpura . There are 5 criteria mild and asymptomatic thrombocytopenia no evidence of fetal thrombocytopenia development late in pregnancy no history of thrombocytopenia outside of pregnancy spontaneous resolution once the child is delivered References http emedicine.medscape.com article 272867 overview http www.haematologica.org cgi reprint 82 3 341.pdf http qjmed.oxfordjournals.org cgi content abstract 84 1 593 Pathology of pregnancy, childbirth and the puerperium Category Maternal disorders predominantly related to pregnancy ... more details
Infobox Disease Name Congenital amegakaryocytic thrombocytopenia Image Caption DiseasesDB ICD10 ICD9 ICD9 287.33 , ICD9 287.5 ICDO OMIM 604498 MedlinePlus eMedicineSubj eMedicineTopic MeshID Congenital amegakaryocytic thrombocytopenia CAMT is a rare inherited disorder. ref name pmid11133753 cite journal author Ballmaier M, Germeshausen M, Schulze H, et al. title c mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia journal Blood volume 97 issue 1 pages 139 46 year 2001 month January pmid 11133753 doi 10.1182 blood.V97.1.139 url http www.bloodjournal.org cgi pmidlookup?view long&pmid 11133753 ref ref name pmid16470591 cite journal author Germeshausen M, Ballmaier M, Welte K title MPL mutations in 23 patients suffering from congenital amegakaryocytic thrombocytopenia the type of mutation predicts the course of the disease journal Hum. Mutat. volume 27 issue 3 pages 296 year 2006 month March pmid 16470591 doi 10.1002 humu.9415 ref ref name pmid18240171 cite journal author Rose MJ, Nicol KK, Skeens MA, Gross TG, Kerlin BA title Congenital amegakaryocytic thrombocytopenia the diagnostic importance of combining pathology with molecular genetics journal Pediatr Blood Cancer volume 50 issue 6 pages 1263 5 year 2008 month June pmid 18240171 doi 10.1002 pbc.21453 ref Presentation The primary manifestations are thrombocytopenia and megakaryocytopenia , or low numbers of platelets and megakaryocytes. There is an absence of megakaryocytes in the bone marrow with no associated ... author Freedman MH, Estrov Z title Congenital amegakaryocytic thrombocytopenia an intrinsic hematopoietic ... mpl gene in congenital amegakaryocytic thrombocytopenia journal Proc. Natl. Acad. Sci. date 1999 volume ... thrombocytopenia journal Blood. date 2001 volume 97 pages 139 46 doi 10.1182 blood.V97.1.139 pmid ... M, Strauss G, Welte K, Ballmaier M title Congenital amegakaryocytic thrombocytopenia a retrospective ... External links http www.marrowfailure.cancer.gov index.html Amegakaryocytic Thrombocytopenia research ... more details
Infobox Disease Name Fetal and Neonatal Alloimmune Thrombocytopenia Image Caption DiseasesDB 33767 ICD10 ICD10 P 61 0 p 50 ICD9 ICD9 776.1 ICDO OMIM MedlinePlus eMedicineSubj med eMedicineTopic 3256 eMedicine mult eMedicine2 med 3480 MeshName MeshNumber Neonatal Alloimmune Thrombocytopenia NAITP or NAIT or NAT for short or fetal and neonatal alloimmune thrombocytopenia , FNAIT , feto maternal alloimmune thrombocytopenia , FMAITP or FMAIT is a disease that affects fetus es and neonates newborns . Genetic ... ref Porcelijn L, Van den Akker ES, Oepkes D. Fetal thrombocytopenia Review . Semin Fetal Neonatal ... data patho GB uk NAIT.pdf work Orphanet Encyclopedia title Fetal and Neonatal Alloimmune Thrombocytopenia ... Diagnosis of Neonatal Alloimmune Thrombocytopenia Using Allele Specific Oligonucleotide Probes ... in pregnancy for fetal or neonatal alloimmune thrombocytopenia systematic review. BJOG 2010 Jul 8. Epub ahead of print ref Signs and Symptoms Frequently, the thrombocytopenia is mild and the affected .... In case of severe thrombocytopenia, the neonates may exhibit hemorrhagic complication at or a few ... M, Schmidt S, et al. 348 cases of fetal alloimmune thrombocytopenia. Lancet 1989 1 363 6. ref Unlike ... fetuses may develop severe thrombocytopenia 50,000 L very early during pregnancy. Usually, the thrombocytopenia ... the severity of thrombocytopenia. The most common treatment is weekly IVIG infusions at a dosage ... med topic3256.htm work eMedicine title Immune Thrombocytopenia and Pregnancy author Lynnae ... A, Kanhai HH.Noninvasive antenatal management of fetal and neonatal alloimmune thrombocytopenia safe ... of thrombocytopenia in some. Also it is suspected that though not understood why IVIG provides ... effective treatment in infants with severe hemorrhage and or severe thrombocytopenia 30x10 sup 9 sup ... the causative antigen . Additionally if the thrombocytopenia in the infant at birth is not severe ... in the perinatal period DEFAULTSORT Neonatal Alloimmune Thrombocytopenia Category Coagulopathies Category ... more details
Infobox disease Name Severe fever with thrombocytopenia syndrome Image Caption DiseasesDB ICD10 ICD10 A 99 a 90 ICD9 ICD9 065.9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic eMedicine mult MeshID D002044 Severe fever with thrombocytopenia syndrome SFTS is an emerging infectious disease recently discovered in northeast and central China. SFTS cause high fatality rate of 12 and as high as 30 in some areas. The major clinical symptoms of SFTS are fever, vomiting, diarrhea, multiple organ failure, thrombocytopenia low platelet count , leucopenia low white blood cell count , and elevated liver enzyme level. SFTS occurs in rural areas from March to November, and a majority of cases are from April to July. In 2009 Xue jie Yu and colleagues isolated the SFTS virus SFTSV from SFTS patients blood. SFTSV is a Phlebovirus in the family of Bunyaviridae . The life cycle of the SFTSV most likely involves arthropod vectors and animal hosts. Humans are accidental hosts and play no role in the life cycle of the SFTSV. SFTSV has been detected from Haemaphysalis longicornis ticks. The transmission routine of SFTSV is unknown, but person to person transmission either plays no role or at least is not an important routine of transmission of SFTSV. ref http www.nejm.org doi full 10.1056 NEJMoa1010095 Yu XJ, Liang MF, Zhang SY, Liu Y, Li JD, Sun YL, et al. Fever with Thrombocytopenia Associated with a Novel Bunyavirus in China. N Engl J Med. 2011 Apr 21 364 16 1523 32. ref File Bunyavirus china.JPG thumb SFTS bunyavirus isolated from patients in Central and Northeast provinces of China red References Reflist Categories Category Arthropod borne viral fevers and viral haemorrhagic fevers Category Bunyaviruses Category Insect borne diseases Category Zoonoses fr Syndrome de fi vre s v re avec thrombocytop nie zh ... more details
Infobox Disease Name Heparin induced thrombocytopenia Image PBB Protein PF4 image.jpg Alt Caption A schematic drawing of platelet factor 4, which when bound to heparin leads to an immune response in HIT ... eMedicineSubj article eMedicineTopic 1357846 MeshID Not coded Heparin induced thrombocytopenia HIT is the development of thrombocytopenia a low platelet count , due to the administration of various ... thrombocytopenia and thrombosis HITT . HIT is caused by the formation of abnormal antibody antibodies ... journal author Ahmed I, Majeed A, Powell R title Heparin induced thrombocytopenia diagnosis and management ... induced thrombocytopenia a historical perspective journal Blood volume 112 issue 7 pages 2607 16 year ... the normal range, a condition called thrombocytopenia . However, it is generally not low enough to lead ... in individuals with thrombocytopenia and thrombosis who had no prior exposure to heparin sulfate ... resembling heparin induced thrombocytopenia journal Am J Med volume 121 pages 632 6 doi 10.1016 ... to thrombocytopenia. ref name Ahmed ref name Warkentin2006 Formation of PF4 heparin antibodies is common in people receiving heparin, but only a proportion of these develop thrombocytopenia or thrombosis ... S, Watson H title The management of heparin induced thrombocytopenia journal Br. J. Haematol. volume ... with a falling platelet count while receiving heparin turn out to have HIT. The timing, severity of the thrombocytopenia ... cgi content full 2003 1 497 ref Thrombocytopenia 2 points if the fall in platelet count ... author Hirsh J, Heddle N, Kelton J title Treatment of heparin induced thrombocytopenia a critical review ... 1958 month February pmid 13497418 ref The fact that this phenomenon occurred together with thrombocytopenia ... Heparin induced thrombocytopenia. An unexpected response to treatment of consumption coagulopathy ... Heparin induced thrombocytopenia with thrombotic and hemorrhagic manifestations journal Surg Gynecol .... ref name KeltonWarkentin Older terminology distinguishes between two forms of heparin induced thrombocytopenia ... more details
CAMT may refer to Center for Arts Management and Technology Thrombocytopenia Congenital Amegakaryocytic Thrombocytopenia Commission on Accreditation of Medical Transport Systems disambig ... more details
NAIT may refer to National Animal Identification and Tracing in New Zealand National Association of Industrial Technology Neonatal alloimmune thrombocytopenia North American Islamic Trust , an organization in Plainfield, Indiana in the United States Northern Alberta Institute of Technology disambig ... more details
HITT can refer to Heparin induced thrombocytopenia , a type of disease HITT Production , a Turkey Turkish record label HITT band , a South Korean boy band People Bryan Hitt , the drummer of American rock band REO Speedwagon Jack Hitt , an American author John Hitt , the president of the University of Central Florida disambig ... more details
Multifocal lymphangioendotheliomatosis also known as Congenital cutaneovisceral angiomatosis with thrombocytopenia, ref name Bolognia and Multifocal Lymphangioendotheliomatosis with thrombocytopenia ref name Bolognia cite book author Rapini, Ronald P. Bolognia, Jean L. Jorizzo, Joseph L. title Dermatology 2 Volume Set publisher Mosby location St. Louis year 2007 pages isbn 1 4160 2999 0 oclc doi accessdate ref presents at birth with hundreds of red brown plaques as large as several centimeters. ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. ISBN 0 7216 2921 0. ref rp 596 See also Skin lesion List of cutaneous conditions References reflist Dermal growth stub Vascular tumors Category Dermal and subcutaneous growths ... more details
Infobox disease Name TAR Syndrome br Thrombocytopenia br with Absent Radius Image Caption DiseasesDB 29769 ICD10 ICD10 Q 87 2 q 80 ICD9 ICD9 287.33 ICDO OMIM 274000 MedlinePlus eMedicineSubj eMedicineTopic MeshID TAR Syndrome Thrombocytopenia with Absent radius is a rare genetic disorder that is characterized by the absence of the Radius bone radius bone in the forearm, and a dramatically reduced platelet count. This syndrome may occur as a part of the 1q21.1 deletion syndrome Presentation Symptoms of thrombocytopenia , or a lowered platelet count, leads to bruising and potentially life threatening hemorrhage . Other common links between people with TAR seem to include heart problems, kidney problems, knee joint problems, frequently lactose intolerance and often thumb hypoplasia File Chromosome 1 to 1q21.1.jpg thumb right 500px The structure of 1q21.1 Treatment Treatments range from platelet transfusions to surgery aimed at normalizing the appearance of the arm, which is much shorter and clubbed. There is some controversy surrounding the role of surgery. The infant mortality rate has been curbed by new technology, including platelet transfusions, which can even be performed in utero . The critical period is the first year of life. For most people with TAR, platelet counts improve as they grow out of childhood. Genetics Genetic research is underway. A 2007 research article identified a region of chromosome 1, 1q21.1, containing 11 genes including Hemojuvelin HFE2 , LIX1L , PIAS3 , ANKRD35 , ITGA10 , RBM8A , PEX11B , POLR3GL , TXNIP , and GNRR2 , that is heterozygously deleted in thirty of thirty patients with TAR. ref cite journal author Klopocki E, Schulze H, Strauss G, et ... in Thrombocytopenia Absent Radius Syndrome journal Am. J. Hum. Genet. volume 80 issue 2 pages ... http www.marrowfailure.cancer.gov index.html Thrombocytopenia Absent Radii research study of Inherited ... GeneReview NCBI NIH UW entry on Thrombocytopenia Absent Radius Syndrome Myeloid hematologic disease ... more details
Onyalai is a form of thrombocytopenia that affects some of the population in areas of central Africa . ref name Onyalai cite web url http www.itg.be evde 45 Haematologyp6.htm title Onyalai work accessdate ref Onyalai exhibits similarities to idiopathic thrombocytopenic purpura ITP but differs in pathogenesis . The affected age range is from less than a year to 70 years and seems to not be gender specific in the same manner as ITP. Cases generally peak between 11 and 20 years old. Although the cause of onyalai is not known at this time, inadequate nutrition and or the consumption of tainted food are suspected. ref name Onyalai Signs and symptoms Onyalai is an acute disease that results in the development of hematoma on oral mucous membranes . Hemorrhagic lesion s may develop on the skin, including on the soles of the feet. ref name Onyalai The patient does not initially appear to be in distress, which may result in a delay of diagnosis. As the disease progresses, hematuria and melena will develop. Epistaxis , petechiae and ecchymoses are common symptoms, as are subconjunctival bleeding and menorrhagia . On average, bleeding will persist for approximately eight days, and may reoccur. ref name Onyalai Approximately 80 percent of cases will exhibit chronic thrombocytopenia. Periodic episodes of acute hemorrhage are also possible and may be severe, possibly leading to shock circulatory shock and death . ref name Onyalai References reflist Category Coagulopathies circulatory stub Disease stub ... more details
Unreferenced stub auto yes date December 2009 Cytopenia is a reduction in the number of blood cell s. It takes a number of forms Low red blood cell count resulting in anemia . Low white blood cell count leukopenia or neutropenia because neutrophil s make up at least half of all white cells, they are almost always low in leukopenia . Low platelet count thrombocytopenia . Low granulocyte count granulocytopenia Pathology granulocytopenia Low red blood cell, white blood cell, and platelet counts pancytopenia . See also Polycythemia , the opposite of cytopenia Category Blood disorders Med stub de Zytopenie it Citopenia ... more details
HIC may refer to Habitat International Coalition Head impact criterion , a measure of the likelihood of head injury generated by crash tests Henry Ian Cusick , an actor Heparin induced thrombocytopenia , a complication of heparin used post surgery. HiC , a C compiler and integrated development environment Hipparcos Input Catalogue , an astronomical catalogue Hot in Cleveland , a TV series United Nations Humanitarian Information Centers Hydrophobic Interaction Chromatography , a chemistry technique Hydraulic Integrated Circuit, a complex valve made with modular hydraulic valves into a single block Hic may refer to The onomatopoeia for the sound made when hiccup ing See also Hi C disambiguation disambig de HIC ... more details
Infobox disease Name Griscelli syndrome type 2 Image Alt Caption DiseasesDB ICD10 ICD9 ICDO OMIM 607624 MedlinePlus eMedicineSubj eMedicineTopic MeshID GeneReviewsID GeneReviewsName Griscelli syndrome type 2 also known as Partial albinism with immunodeficiency is a rare autosomal recessive syndrome characterized by variable pigmentary dilution, hair with silvery metallic sheen, frequent pyogenic infections, neutropenia , and thrombocytopenia . ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. ISBN 0 7216 2921 0. ref rp 866 See also Griscelli syndrome References reflist Cutaneous condition stub Pigmentation disorders Deficiencies of intracellular signaling peptides and proteins Category Disturbances of human pigmentation ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 Y43.3 ICD9 ICD9 E933.1 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Hydroxyurea dermopathy is caused by chronic use of hydroxyurea for chronic myelogenous leukemia , thrombocytopenia, or psoriasis, and presents with skin lesion s characteristic of dermatomyositis . ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. ISBN 0 7216 2921 0. ref rp 135 See also Skin lesion List of cutaneous conditions References reflist Cutaneous condition stub External causes of morbidity and mortality Category Drug eruptions ... more details
Taxobox Color parameter is not needed automatically assigned name Phleboviruses virus group v ordo Unassigned familia Bunyaviridae genus Phlebovirus SFTSV is a Phlebovirus in the family of Bunyaviridae . ref name Xue jie Yu et al. Fever with thrombocytopenia asshociated with a novel Bunyavirus in China. N Engl J Med. 2011 Mar 16. http www.nejm.org doi full 10.1056 NEJMoa1010095 t article Full text ref It appears to be more closely related to the Uukuniemi virus serogroup than to the Sandfly fever group. It may be the prototype of a new serogroup within the Phlebovirus genus as it is only distantly related to both the existing serogroups. The clinical condition it causes is known as severe fever with thrombocytopenia syndrome SFTS . SFTS is an emerging infectious disease recently described in northeast and central China. SFTS has a fatality rate of 12 and as high as 30 in some areas. The major clinical symptoms of SFTS are fever, vomiting, diarrhea, multiple organ failure, thrombocytopenia low platelet count , leucopenia low white blood cell count and elevated liver enzyme levels. History In 2009 Xue jie Yu and colleagues isolated the SFTS virus SFTSV from SFTS patients blood. ref name Xue jie Yu et al. Genome The genome has been sequenced. ref name Lu2011 Lu J, Li C, Zhang FS, Wu W, Zhang QF, Zhang L, Wang T, Wang Q, Qiu PH, Liang MF, Li DX 2011 Expression of structural and non structural proteins of severe fever with thrombocytopenia syndrome bunyavirus. Bing Du Xue Bao 27 6 515 520 ref There are three segments large L , medium M and small S Six proteins have been identified an RNA dependent RNA polymerase RdRp , a glycoprotein precursor M , a glycoprotein N Gn , a glycoprotein C Gc , a nuclear protein NP and a non structural protein NSs . The L segment encodes the RNA polymerase with 2084 amino acid residues. The M segment encodes one open reading frame encoding 1073 amino acid precursors of glycoproteins Gn and Gc . The S segment has 1744 nucleotides of ambisense ... more details
in patients with heparin induced thrombocytopenia HIT . In 2002, it was approved for use ... Thrombocytopenia. Am J Cardiovasc Drugs 2009 9 4 261 82. http adisonline.com cardiovascular pages ... . Transitioning to warfarin in individuals with heparin induced thrombocytopenia Argatroban is used as an anticoagulant in individuals with thrombosis and heparin induced thrombocytopenia. Often these individuals ... to warfarin therapy in patients with heparin induced thrombocytopenia. journal Clin Appl Thromb Hemost ... more details
Infobox Disease Name PAGENAME Image thrombotic microangiopathy very high mag.jpg Caption Micrograph of thrombotic microangiopathy with the characteristic onion skin layering seen in older lesions. PAS stain . DiseasesDB ICD10 ICD10 M 31 1 m 30 ICD9 ICD9 446.6 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Thrombotic microangiopathy , abbreviated TMA , is a pathology that results in thrombosis in capillaries and arterioles , due to an endothelial injury. ref name pmid20186056 Cite journal last1 Benz first1 K. last2 Amann first2 K. title Thrombotic microangiopathy new insights. journal Curr Opin Nephrol Hypertens volume 19 issue 3 pages 242 7 month May year 2010 doi 10.1097 MNH.0b013e3283378f25 PMID 20186056 ref It may be seen in association with thrombocytopenia , anemia , purpura and renal failure . The classic TMAs are hemolytic uremic syndrome and thrombotic thrombocytopenic purpura . Other conditions with TMA include disseminated intravascular coagulation , scleroderma renal crisis, malignant hypertension , antiphospholipid antibody syndrome , and drug toxicities, e.g. calcineurin inhibitor toxicity. ref name pmid20186056 Etiology The etiology is dependent on the specific TMA. Bacterial toxins are the primary cause of one category of thrombotic microangiopathy known as HUS or hemolytic uremic syndrome . The another major category is TTP or thrombotic thrombocytopenic purpura . It is caused by autoimmune or hereditary dysfunctions that activate the coagulation cascade or the complement system . Some sources group TTP and HUS together ref http www.merckmanuals.com professional sec12 ch143 ch143g.html ref , while other sources express skepticism about their common pathophysiology. ref http www.emedicine.com emerg topic579.htm ref Presentation The clinical presentation typically includes fever , microangiopathic hemolytic anemia see schistocytes in a blood smear , renal failure , thrombocytopenia , neurological manifestations. Treatment The treatment depen ... more details
Infobox Disease Name Phlegmasia cerulea dolens Image Caption DiseasesDB 32484 ICD10 ICD9 ICDO OMIM MedlinePlus 000200 eMedicineSubj med eMedicineTopic 2767 MeshID Phlegmasia cerulea dolens literally painful blue edema is an uncommon severe form of deep venous thrombosis which results from extensive Thrombosis thrombotic occlusion blockage by a blood clot of the major and the Arteriovenous anastomosis collateral veins of an extremity. ref name ACS cite web url http www.acssurgery.com acs chapters ch0606.htm title Management of Venous Thromboembolism author John T. Owings date December 2005 work ACS Surgery publisher American College of Surgeons accessdate January 16, 2012 ref ref Cite journal title Images in Clinical Medicine Phlegmasia Cerulea Dolens last Barham first Kalleen coauthors Tina Shah date 2007 01 18 journal The New England Journal of Medicine volume 356 issue 3 pages e3 pmid 17229945 doi 10.1056 NEJMicm054730 ref It is characterized by sudden severe pain, swelling, cyanosis and edema of the affected limb. There is a high risk of massive pulmonary embolism , even under anticoagulation . Foot gangrene may also occur. An underlying malignancy is found in 50 of cases. Usually, it occurs in those afflicted by a life threatening illness. ref name ACS This phenomenon was discovered by Jonathan Towne , a vascular surgeon in Milwaukee , who was also the first to report the white clot syndrome now called heparin induced thrombocytopenia HIT . Two of their HIT patients developed phlegmasia cerulea dolens that went on to become gangrenous. ref Heparin Induced Thrombocytopenia By Theodore E. Warkentin, Andreas Greinacher, Published 2004, ISBN 0824756258 ref See also Phlegmasia alba dolens References reflist DEFAULTSORT Phlegmasia Cerulea Dolens Category Inflammations Category Vascular diseases disease stub de Phlegmasia coerulea dolens es Flegmasia cerulea dolens tr Phlegmasia coerulea dolens ... more details
Drugbox Verifiedfields changed verifiedrevid 464384589 Monoclonal antibody data type mab mab type mab source zu o target CD154 Clinical data tradename pregnancy AU pregnancy US pregnancy category legal AU legal CA legal UK legal US legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers CAS number Ref cascite changed ?? CAS number 220651 94 5 ATC prefix none ATC suffix PubChem DrugBank Ref drugbankcite correct drugbank DrugBank Chemical data ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID NA chemical formula molecular weight Ruplizumab trade name Antova is a humanized monoclonal antibody intended for the treatment of rheumatic disease s like systemic lupus erythematosus and lupus nephritis . A study showed that the drug was associated with life threatening thromboembolism s, ref cite journal pmid 15046525 year 2004 last1 Liossis first1 SN last2 Sfikakis title Costimulation blockade in the treatment of rheumatic diseases volume 18 issue 2 pages 95 102 journal BioDrugs clinical immunotherapeutics, biopharmaceuticals and gene therapy first2 PP doi 10.2165 00063030 200418020 00003 ref while another study only found thrombocytopenia . ref cite journal doi 10.1093 rheumatology kei118 pmid 16188945 year 2006 last1 Nakamura first1 M last2 Tanaka first2 Y last3 Satoh first3 T last4 Kawai first4 M last5 Hirakata first5 M last6 Kaburaki first6 J last7 Kawakami first7 Y last8 Ikeda first8 Y last9 Kuwana first9 M title Autoantibody to CD40 ligand in systemic lupus erythematosus association with thrombocytopenia but not thromboembolism volume 45 issue 2 pages 150 6 journal Rheumatology Oxford, England ref References reflist immunosuppressants Monoclonals for immune system Category Monoclonal antibodies monoclonal antibody stub antineoplastic drug stub ... more details
Clot retraction is the shrinking of a blood clot over a number of days. In so doing, the edges of the blood vessel wall at the point of injury are slowly brought together again to repair the damage. Clot retraction is dependent on release of multiple coagulation factors from platelets trapped in the fibrin mesh of the clot. Thus, failure to retract can be a sign of thrombocytopenia or a rare condition called Thrombasthenia. Further reading cite book title Human Physiology The Mechanisms of Body Function author Arthur J. Vander, James H. Sherman, and Dorothy S. Luciano publisher McGraw Hill date 1970 location pages 502 chapter Clot Retraction cite book title Hemostasis in Cardiac editor Safuh Attar pages 118&ndash 120 publisher Blackwell Publishing date 1999 isbn 0879934107 isbn13 9780879934101 author Nikolaos Skubas and George J. Despotis chapter Intraoperative Diagnosis and Therapy of Hemostatis Abnormalities with Cardiac Surgery External links MeshName Clot retraction Category Coagulation system treatment stub Blood physiology ... more details
Refimprove date December 2009 Mean platelet volume MPV is a machine calculated measurement of the average size of platelets found in blood and is typically included in blood tests as part of the Complete blood count CBC . Since the average platelet size is larger when the body is producing increased numbers of platelets the MPV test results can be used to make inferences about platelet production in bone marrow or platelet destruction problems. ref name LabTestsOnline http www.labtestsonline.org understanding analytes cbc test.html , Lab Tests Online. ref MPV is higher when there is destruction to platelets. This may be seen as in immune thrombocytopenic purpura ITP , and in myeloproliferative disease s and Bernard Soulier syndrome . It may also be related to pre eclampsia , and recovery from transient hypoplasia . ref name Arch Pathol Lab Med. Vol 133, September 2009 1441 43. http docs.google.com viewer?a v&q cache WD fbfqdadUJ www.metromedlab.com SiteContent Documents File IPN 2520MPV 2520 2520101609.pdf 22mean platelet volume 22&hl en&gl us&pid bl&srcid ADGEESjXgOqNk6 jITg3Rn c64mK0iSxOTrt5I6VycZ4yzlEf3z1ycjsY 1nU1H8hiYmppb3QKniYikKEIXM0CDCnwSvavxsO9wmKvgM2778hWm2McGaIv0Dz0GJzND39M3h3G29wxdw&sig AHIEtbSsN2L1cvMZLM4tJ5snc9 uaKIADQ&pli 1 , Arch Pathol Lab Med. Vol 133, September 2009 1441 43.. ref Abnormally low MPV values correlate primarily with thrombocytopenia when it is due to impaired production as in aplastic anemia . You may want to research megakaryocyte if you are looking into causes and related information for a low MPV. A typical range of platelet volumes is 9.7 12.8 fL femtolitre , equivalent to spheres 2.65 to 2.9 Micrometre m in diameter. Normal range is given as 7.5 11.5 fL. External links http answers.webmd.com answers 1198044 What is MPV MPV Definition http www.medicinenet.com thrombocytopenia low platelet count page4.htm Medicinenet.com Thrombocytopenia http www.diabetesexplained.com mean platelet volume.html Diabetesexplained.com MPV ... more details
This suggested that low platelet counts thrombocytopenia in patients with ITP was caused by a circulating ... cite journal author Tomer A, Koziol J, McMillan R title Autoimmune thrombocytopenia flow cytometric ... Thrombocytopenia caused by the development of antibodies to thrombopoietin journal Blood volume ... more details
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