Image Amitriptyline.svg thumb right Chemical structure of the tricyclicantidepressant amitriptyline . Notice its three functional group ring s. Tricyclic antidepressants TCAs are heterocyclic chemical compound s used primarily as antidepressant s. The TCAs were first discovered in the early 1950s and were ... ref ref name pmid17471183 cite journal author Gillman PK title Tricyclicantidepressant pharmacology ... cite journal author Green JP, Maayani S title Tricyclicantidepressant drugs block histamine ... cite journal author Harrigan RA, Brady WJ title ECG abnormalities in tricyclicantidepressant ... Rosenbaum T, Kou M title Are one or two dangerous? Tricyclicantidepressant exposure in toddlers ... Serotonergics Tricyclics DEFAULTSORT TricyclicAntidepressant Category Tricyclic antidepressants ar ... of atom s. The tetracyclic antidepressant s TeCAs , which contain four rings of atoms, are a closely related group of antidepressant compounds. In recent times, the TCAs have been largely replaced in clinical ... of antidepressant effects was published by Swiss psychiatrist Ronald Kuhn in 1957. ref name assets.cambridge.org ... described share a tricyclic backbone different from the backbone of the TCA amitriptyline . Merck & Co ... enuresis NE , ref name pmid12917922 cite journal author Glazener C, Evans J, Peto R title Tricyclic ... moclobemide . However, tricyclic antidepressants still are probably more successful in treating melancholic depression than other antidepressant drug classes. ref name pmid7980178 cite journal author ... M, Glod C, Cole J title Antidepressant drugs and the emergence of suicidal tendencies journal ... M, Gav riaux Ruff C, Yalcin I, et al. title Delta opioid receptors are critical for tricyclicantidepressant treatment of neuropathic allodynia journal Biological Psychiatry volume 63 issue 6 ... s. ref name pmid9551776 cite journal author R n ric JP, Lucki I title Antidepressant behavioral effects ... MA, Loo PS title Tricyclic antidepressants and dextromethorphan bind with higher affinity to the phencyclidine ... more details
Infobox Disease Name Tricyclicantidepressant overdose Image Amitriptyline.svg Caption Chemical structure of the tricyclicantidepressant amitriptyline DiseasesDB ICD10 ICD10 T 43 0 t 36 ICD9 ICD9 969.0 ICDO OMIM MedlinePlus eMedicineSubj article eMedicineTopic 1010089 MeshID Tricyclicantidepressant overdose is caused by excessive use or overdose of a tricyclicantidepressant drug. It is a significant cause of fatal drug poison ing. The severe morbidity and mortality associated with these drugs is well documented due to their circulatory system cardiovascular and neurology neurological toxicity ...? Tricyclicantidepressant exposure in toddlers journal J Emerg Med volume 28 issue 2 pages 169 74 ... author Thanacoody H, Thomas S title Tricyclicantidepressant poisoning cardiovascular toxicity journal ... KR, Chyka PA, Christianson G, Troutman WG title Tricyclicantidepressant poisoning an evidence ... survey of the management of unintentional low dose tricyclicantidepressant ingestions involving ... S title Tricyclicantidepressant overdose a review journal Emerg Med J volume 18 issue 4 pages ... cite journal author Teece S, Hogg K title Gastric lavage in tricyclicantidepressant overdose journal ... of tricyclicantidepressant poisoning the role of gut decontamination, extracorporeal procedures ... of tricyclicantidepressant poisoning role of sodium bicarbonate journal Toxicol Rev volume ... H title Toxicity of tricyclic antidepressants kinetics, mechanism, intervention a review journal ... are not useful for evaluating risk of arrhythmia or seizure in tricyclic overdose. ref name NEngJMed1985 ... after an acute overdose of tricyclic antidepressants journal N Engl J Med volume 313 issue 8 pages ... muscular overactivity. There is no role for physostigmine in the treatment of tricyclic toxicity as it may increase cardiac toxicity and cause seizures. ref name EmergMedJ2001 Kerr Tricyclic antidepressants ... and Wales between 1993 and 1997 were associated with tricyclic antidepressants, particularly dothiepin ... more details
Image Dibenzazepine.png thumb right 200px Dibenzazepine Image Phenothiazin.svg thumb right 200px Phenothiazine Tricyclics are chemical compound s that contain three interconnected cyclic compound rings of atom s. Many compounds have a tricyclic structure, but in pharmacology , the term has traditionally been reserved to describe heterocyclic drugs. Among these are antidepressant s, antipsychotic s, and antihistamine s as antiallergen s, anti motion sickness drugs, antipruritic s, and hypnotic s sedative s of the dibenzazepine , dibenzocycloheptene , dibenzothiazepine , dibenzothiepin , phenothiazine , and thioxanthene chemical class es, and others. History Promethazine and other first generation antihistamines with a tricyclic structure were discovered in the 1940s. Chlorpromazine , derived from promethazine originally as a sedative, was found to have neuroleptic properties in the early 1950s, and was the first typical antipsychotic . Imipramine , originally investigated as an antipsychotic, was discovered in the early 1950s, and was the first tricyclic antidepressant . Antidepressants with a tetracyclic structure such as mianserin and maprotiline were first developed in the 1970s as tetracyclic antidepressant s. Clozapine was introduced as the first atypical antipsychotic in the 1990s. Loratadine was introduced as a non sedating second generation antihistamine in the 1990s. ref cite pmid 10444229 ref Gallery class wikitable style font size smaller text align center colspan 5 Antidepressants File Imipramine.svg 135px Imipramine File Amitriptyline.svg 135px Amitriptyline File Mirtazapine.svg 135px Mirtazapine File Iprindole.png 135px Iprindole File Tianeptine.svg 135px Tianeptine colspan 5 Antipsychotics File Chlorpromazin.svg 135px Chlorpromazine File Thioridazine 2D skeletal.png 135px Thioridazine File Cis Chlorprothixen.png 135px Chlorprothixene File Loxapine.svg 135px Loxapine File Clozapine.svg 135px Clozapine colspan 5 Antihistamines File Promethazine.svg 135px ... more details
Tricyclic antidepressants Tricyclicantidepressant s are the second oldest class of antidepressant ... structure of venlafaxine Effexor , an Serotonin norepinephrine reuptake inhibitor SNRI An antidepressant ... inhibitors MAOIs , tricyclic antidepressants TCAs , tetracyclic antidepressants TeCAs , selective serotonin ... sometimes to treat snoring and migraines . Many drugs produce an antidepressant effect, but restrictions ... opioids and amphetamines are greater than those of the tricyclic anti depressants. In a small study ... St John s Wort is commonly used as an antidepressant especially in Europe, although it is labeled as a dietary supplement in some countries. The term antidepressant is sometimes applied to any therapy ... s can have significant antidepressant effects, and so to establish a substance as an antidepressant ... publication of antidepressant trials and its influence on apparent efficacy journal N. Engl. J .... title Venlafaxine and mirtazapine different mechanisms of antidepressant action, common opioid mediated ... Antidepressant Action Systematic Review and Meta analysis journal Arch Gen Psychiatry volume 63 issue ... form of antidepressant that work on both norepinephrine and 5 HT. They typically have similar side ... and specific serotonergic antidepressant s NaSSAs form a newer class of antidepressants that are purported ... GL year 1997 month Jan Feb title Mirtazapine an antidepressant with noradrenergic and specific serotonergic ... cause a fatal arrhythmia. However, tricyclic antidepressants are still used because of their effectiveness ... amine tricyclic antidepressants Amitriptyline Elavil, Endep Clomipramine Anafranil Doxepin Adapin, Sinequan Imipramine Tofranil Trimipramine Surmontil Secondary amine tricyclic antidepressants ... inhibitor Irreversible monoamine oxidase inhibitor s MAOIs may be used if other antidepressant medications ... emsam the first year accessdate 2009 11 30 ref MAOIs can be as effective as tricyclic ... as SSRIs and tricyclic antidepressants, in depressive disorders, ref name pmid7717091 cite journal ... more details
A Heterocyclic antidepressant inhibits the neuron nerve cells ability reuptake norepinphrine and serotonin . This group of drugs, once the mainstay of treatment, includes tricyclic tertiary amines amitriptyline and imipramine and their secondary amine metabolites nortriptyline and desipramine , modified Tricyclicantidepressanttricyclic , and tetracyclic antidepressants . External links http psyweb.com Glossary hetero.jsp PSYweb Heterocyclic Antidepressants http www.healthyplace.com communities depression treatment antidepressants tricyclic.asp HealthyPlace.com Tricyclic TCAs and Heterocyclic Antidepressants For Depression http www.merck.com mmpe sec15 ch200 ch200b.html Depressive Disorders, Mood Disorders, Merck Manual Professional med stub Category Antidepressants ... more details
Image Iproniazid.svg thumb right 200px Iproniazid , the first hydrazine MAOI to be discovered, and the first antidepressant drug ever marketed. The hydrazine antidepressant s are a group of non binding selectivity selective and irreversible inhibition irreversible monoamine oxidase inhibitor s MAOIs that were discovered and initially marketed in the 1950s and 60s. Most have been withdrawal withdrawn due to toxic adverse reaction reaction s like hepatotoxicity , but several still remain in clinical use. Tranylcypromine , a chemical structure structurally unrelated MAOI introduced around the same time as the hydrazines, was originally advertised as non hydrazine, due to its diminished propensity for causing hepatotoxicity and related side effect s. List of hydrazine antidepressants div style moz column count 2 column count 2 webkit column count 2 Benmoxin Neuralex, Nerusil sup sup Iproclozide Sursum sup sup Iproniazid Marsilid sup sub Isocarboxazid Marplan Mebanazine Actomol sup sup Metfendrazine MO 482 sup sup Nialamide Niamid sup sub Octamoxin Ximaol, Nimaol sup sup Phenelzine Nardil Pheniprazine Catron sup sup Phenoxypropazine Drazine sup sup Pivalylbenzhydrazine Tersavid sup sup Safrazine Safra sup sub div sup sup Withdrawn from the market sup sub Partially discontinued sup sup Never marketed. See also Monoamine oxidase inhibitor References Reflist cite journal author L pez Mu oz F, Alamo C title Monoaminergic neurotransmission the history of the discovery of antidepressants from 1950s until today journal Current Pharmaceutical Design volume 15 issue 14 pages 1563 86 year 2009 pmid 19442174 doi 10.2174 138161209788168001 url http www.bentham direct.org pages content.php?CPD 2009 00000015 00000014 0002B.SGM Antidepressants Anxiolytics Adrenergics Dopaminergics GABAergics Serotonergics Hydrazines Category Antidepressants Category Hydrazines Category Monoamine oxidase inhibitors Category Withdrawn drugs ... more details
The second generation antidepressants are a class of antidepressants characterized primarily by the era of their introduction approximately coinciding with the 1970s and 1980s , rather than by their chemical structure or by their pharmacological effect. As a consequence, there is some controversy over which treatments actually belong in this class. The term Third generation antidepressant is sometimes used to refer to even newer antidepressants, ref name pmid11735614 cite journal author Olver JS, Burrows GD, Norman TR title Third generation antidepressants do they offer advantages over the SSRIs? journal CNS Drugs volume 15 issue 12 pages 941 54 year 2001 pmid 11735614 doi 10.2165 00023210 200115120 00004 url ref often selective serotonin reuptake inhibitor s such as fluoxetine , paroxetine and sertraline , as well as some Non SSRI antidepressants such as mirtazapine , nefazodone , venlafaxine , duloxetine and reboxetine . However, this usage is not universal. Examples This list is not exhaustive, and different sources vary upon which items should be considered second generation. Amoxapine Bupropion Iprindole Maprotiline Mianserin Nomifensine Trazodone Trimipramine Viloxazine References Reflist External links MeshName Second Generation Antidepressive Agents http www.toxlab.co.uk tca2nd.htm Second 20Generation Diagrams at toxlab.co.uk http jcp.sagepub.com cgi content abstract 25 4 241 Overview at sagepub.com http psyweb.com Glossary sga.jsp Overview at psyweb.com http www.sciencedaily.com releases 2005 09 050920081731.htm Overview at sciencedaily.com http sabryabdelfattah.tripod.com docs ANTIDPRS.htm Overview at sabryabdelfattah.tripod.com Antidepressants Category Antidepressants nervous system drug stub ... more details
Amitriptyline may refer to Amitriptyline , sold as Elavil, Tryptanol, Endep, Elatrol, Tryptizol is a tricyclicantidepressant drug Amitriptyline, a song by John Vanderslice from his 2002 album Life and Death of an American Fourtracker disambig ... more details
Triazolopyridine is a class of antidepressants chemically and pharmacologically unrelated to other similarly performing antidepressants clinical effectiveness appears pharmacologically similar to other tricyclic antidepressants , although it seems to have less anticholinergic effects. Triazolopyridine has been investigated as a possible metabolite for the location of certain bonds in specific fatty acids. A popular antidepressant of this class is known as Trazodone . Category Tricyclic antidepressants Category Triazolopyridines nervous system drug stub ... more details
Drugbox IUPAC name N , N dimethyl 3 11 methylidene 6,11 dihydro 5 H dibenzo b,e azepin 5 yl propan 1 amine image Enprazepine.png Clinical data tradename pregnancy category legal status routes of administration Pharmacokinetic data bioavailability metabolism elimination half life excretion Identifiers CAS number 47206 15 5 ATC prefix None ATC suffix PubChem 208922 ChemSpiderID 181018 UNII Ref fdacite correct FDA UNII L2H26JSV0I Chemical data C 20 H 24 N 2 molecular weight 292.42 g mol smiles c3cc2c C c1c cccc1 CN2CCCN C C C cc3 Enprazepine is a tricyclic antidepressant TCA which was never marketed. ref name isbn0 412 46630 9 cite book author David J. Triggle title Dictionary of pharmacological agents publisher Chapman & Hall location London year 1997 pages isbn 0 412 46630 9 oclc doi url http books.google.com books?id DeX7jgInYFMC ref See also Tricyclic antidepressant References Reflist Antidepressants Tricyclics Category Amines Category Dibenzazepines Category Tricyclic antidepressants ... more details
Advert 2 an advertisement for the antidepressant agomelatine date January 2011 Unreferenced date March 2010 Tolerability is how Drug tolerance tolerable in terms of side effect s a medication is. As an example, tricyclicantidepressant s TCAs are very poorly tolerated and often produce severe side effects including sedation , orthostatic hypotension , and anticholinergic effects, whereas the newer antidepressant agomelatine has virtually no adverse effects at all and is highly tolerated. See also Side effect References Reflist 2 Medicine Pharmacology Category Pharmacology Pharmacology stub Medicine stub ... more details
Drugbox IUPAC name 3 1a,10b dihydrod ibenzo a, e cyclopr opa c cyc lohepten 6 1 H yli dene N m ethyl 1 p ropanamine image Octriptyline.png Clinical data tradename pregnancy category legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers CAS number 47166 67 6 CAS supplemental br 51481 67 5 phosphate salt ATC prefix ATC suffix PubChem 40029 ChemSpiderID 36588 UNII Ref fdacite correct FDA UNII C3X0UOC25D Chemical data chemical formula C sub 20 sub H sub 21 sub N molecular weight 275.39 g mol Octriptyline SC 27,123 is a tricyclic antidepressant TCA that was never marketed. ref name urlDictionary of pharmacological agents Google Books cite web url http books.google.com books?id A0THacd46ZsC&lpg PA1469&ots IIjkfFuc65&dq 22SC 27 2C123 22 20octriptyline&pg PA1469 v onepage&q 22SC 27,123 22 20octriptyline&f false title Dictionary of pharmacological agents Google Books ref File Octriptyline syn.png 500px Cavalla, J. F. White, A. C. British Patent, 1975, Cite patent GB 1406481 . See also Tricyclic antidepressant References Reflist 2 Antidepressants Anxiolytics Adrenergics Cholinergics Histaminergics Serotonergics Tricyclics Category Tricyclic antidepressants Category Cyclopropanes nervous system drug stub ... more details
Drugbox IUPAC name 1 10,11 dihydro 5 H dibenzo a,d 7 annulen 5 ylidene 3 dimethylamino propan 2 one image Cotriptyline.png Clinical data tradename pregnancy category legal status Uncontrolled routes of administration Mouth Oral Pharmacokinetic data bioavailability metabolism elimination half life excretion Identifiers CAS number 34662 67 4 ATC prefix none ATC suffix PubChem 71935 ChemSpiderID 64945 UNII Ref fdacite correct FDA UNII KQJ4QI511C Chemical data C 20 H 21 N 1 O 1 molecular weight 291.39 g mol smiles O C C C2 c1c cccc1 CCc3c2cccc3 CN C C Cotriptyline SD 2203 01 is a tricyclic antidepressant TCA which was never marketed. ref name isbn0 412 46630 9 cite book author David J. Triggle title Dictionary of Pharmacological Agents publisher Chapman & Hall CRC location Boca Raton year 1996 pages isbn 0 412 46630 9 oclc doi url http books.google.com books?id DeX7jgInYFMC&lpg PA522&dq cotriptyline&as brr 3&pg PA522 v onepage&q&f false ref See also Tricyclic antidepressant References Reflist Antidepressants Anxiolytics Adrenergics Cholinergics Histaminergics Serotonergics Tricyclics Category Amines Category Annulenes Category Tricyclic antidepressants ... more details
Drugbox IUPAC name N , N dimethyl 3 4 H thieno 3,2 b 1 benzazepin 4 yl propan 1 amine image Tienopramine.png Clinical data tradename pregnancy category legal status Uncontrolled routes of administration Mouth Oral Pharmacokinetic data bioavailability metabolism elimination half life excretion Identifiers CAS number 37967 98 9 ATC prefix none ATC suffix PubChem 216992 ChemSpiderID 188026 UNII Ref fdacite correct FDA UNII 36L0QUK8SY Chemical data C 17 H 20 N 2 S 1 molecular weight 284.42 g mol smiles s1ccc2N c3c C C c12 cccc3 CCCN C C Tienopramine is a tricyclic antidepressant TCA which was never marketed. ref name isbn0 412 46630 9 cite book author David J. Triggle title Dictionary of Pharmacological Agents publisher Chapman & Hall CRC location Boca Raton year 1996 pages isbn 0 412 46630 9 oclc doi url http books.google.com books?id A0THacd46ZsC&lpg PA1976&ots IIkjlIt792&dq tienopramine&pg PA1976 v onepage&q&f false ref It is an structural analog analogue of imipramine where one of the benzene functional group ring s has been replaced with a thiophene ring. See also Tricyclic antidepressant References Reflist Antidepressants Anxiolytics Adrenergics Cholinergics Histaminergics Serotonergics Tricyclics Category Amines Category Benzazepines Category Tricyclic antidepressants Category Thiophenes ... more details
Drugbox IUPAC name 2 1 3 5 H dibenzo b,f azepin 5 yl propyl 1 H 1,2 diazepin 4 yl ethanol image Homopipramol.png Clinical data tradename pregnancy category legal status routes of administration Pharmacokinetic data bioavailability metabolism elimination half life excretion Identifiers CAS number 35142 68 8 CAS supplemental br 60563 10 2 fumarate ATC prefix none ATC suffix PubChem 216247 ChemSpiderID 16736632 UNII Ref fdacite correct FDA UNII 09YNW8E5CT Chemical data C 24 H 25 N 3 O 1 molecular weight 371.47 g mol smiles OCC C1 C C C N N C1 CCCN3c4ccccc4 C C c2ccccc23 Homopipramol is a tricyclic antidepressant TCA with neuroleptic properties which was never marketed. ref name isbn0 412 46630 9 cite book author David J. Triggle title Dictionary of pharmacological agents publisher Chapman & Hall location London year 1997 pages isbn 0 412 46630 9 oclc doi url http books.google.com books?id A0THacd46ZsC&lpg PA1031&dq homopipramol&pg PA1031 v onepage&q homopipramol&f false ref See also Tricyclic antidepressant References Reflist Antidepressants Antipsychotics Tricyclics Category Alcohols Category Dibenzazepines Category Tricyclic antidepressants Category 1,2 Diazepines ... more details
Drugbox IUPAC name 3 6,11 dihydro 5 H dibenzo b,e azepin 5 yl N methylpropan 1 amine image Mezepine.png Clinical data tradename pregnancy category legal status routes of administration Pharmacokinetic data bioavailability metabolism elimination half life excretion Identifiers CAS number 27432 00 4 CAS supplemental br 27229 23 8 fumarate br 27470 75 3 oxalate ATC prefix None ATC suffix PubChem 3047746 ChemSpiderID 2310073 UNII Ref fdacite correct FDA UNII P21N4Z6JHO Chemical data C 18 H 22 N 2 molecular weight 266.38 g mol smiles c1cc3c cc1 Cc2c cccc2 CN3CCCNC Mezepine is a tricyclic antidepressant TCA that was never marketed. ref name isbn0 412 46630 9 cite book author David J. Triggle title Dictionary of pharmacological agents publisher Chapman & Hall location London year 1997 pages isbn 0 412 46630 9 oclc doi url http books.google.com books?id A0THacd46ZsC&lpg PA1351&dq mezepine&pg PA1351 v onepage&q mezepine&f false ref See also Tricyclic antidepressant References Reflist Antidepressants Tricyclics Category Amines Category Dibenzazepines Category Tricyclic antidepressants ... more details
Distinguish desipramine Drugbox IUPAC name 3 5 H dibenzo b , f azepin 5 yl N , N dimethylpropan 1 amine image Depramine.png Clinical data tradename pregnancy category legal status routes of administration Pharmacokinetic data bioavailability metabolism elimination half life excretion Identifiers CAS number 303 54 8 ATC prefix None ATC suffix PubChem 67534 ChemSpiderID 60856 UNII Ref fdacite correct FDA UNII 77C3T28736 Chemical data C 19 H 22 N 2 molecular weight 278.39 g mol smiles c3cc2c C C c1c cccc1 N2CCCN C C cc3 Depramine International Nonproprietary Name INN GP 31,406 , also known as balipramine British Approved Name BAN and as 10,11 dehydroimipramine , is a tricyclic antidepressant TCA which was never marketed. ref name isbn0 412 54090 8 cite book author title Dictionary of organic compounds publisher Chapman & Hall location London year 1996 pages isbn 0 412 54090 8 oclc doi url http books.google.com books?id w5dpoQRjGNEC&lpg PA550&dq depramine&pg PA550 v onepage&q depramine&f false ref ref name isbn0 412 46630 9 cite book author David J. Triggle title Dictionary of pharmacological agents publisher Chapman & Hall location London year 1997 pages isbn 0 412 46630 9 oclc doi accessdate ref See also Tricyclic antidepressant References Reflist Antidepressants Tricyclics Category Amines Category Dibenzazepines Category Tricyclic antidepressants ... more details
Drugbox IUPAC name N , N dimethyl 3 6 phenyl 11 H pyrido 2,3 b 1,4 benzodiazepin 11 yl propan 1 amine 2 E but 2 enedioate image Tampramine.png Clinical data tradename pregnancy category legal status Uncontrolled routes of administration Oral Pharmacokinetic data bioavailability metabolism elimination half life excretion Identifiers CAS number 83166 18 1 ATC prefix none ATC suffix PubChem 6450479 ChemSpiderID 4953084 UNII Ref fdacite correct FDA UNII 47GSE5RM8N Chemical data C 27 H 28 N 4 O 4 molecular weight 472.54 g mol smiles O C O C C C O O.N 3 C c1ccccc1 c2ccccc2N c4ncccc 34 CCCN C C Tampramine AHR 9,377 is a tricyclic antidepressant TCA which was developed in the 1980s but was never marketed. ref name pmid6548381 cite journal author Kinnier WJ, Tabor RD, Norrell LY title Neurochemical properties of AHR 9377 a novel inhibitor of norepinephrine reuptake journal Biochemical Pharmacology volume 33 issue 19 pages 3001 5 year 1984 month October pmid 6548381 doi 10.1016 0006 2952 84 90600 2 url http linkinghub.elsevier.com retrieve pii 0006 2952 84 90600 2 ref ref name pmid3936083 cite journal author O Donnell JM, Seiden LS title Effect of the experimental antidepressant AHR 9377 on performance during differential reinforcement of low response rate journal Psychopharmacology volume 87 issue 3 pages 283 5 year 1985 pmid 3936083 doi 10.1007 BF00432708 url ref Despite being a TCA, it acts as a binding selectivity selective norepinephrine reuptake inhibitor and has negligible affinity pharmacology affinity for adrenergic , histaminergic , and muscarinic receptor biochemistry receptor s. ref name pmid6548381 It was found to be effective in the forced swim test FST model of major depression depression in animal studies but is not known to have ever been trialed in humans. ref name pmid3936083 See also Tricyclic antidepressant References Reflist Antidepressants Adrenergics Tricyclics Category Amines Category Pyridobenzodiazepines Category Tricyclic antidepressants ... more details
Drugbox IUPAC name 8,10 dimethyl 8,9,10,11,11a,12 hexahydro 7a H benzo 5,6 chromeno 3,2 c pyridin 7a ol image Naranol.png Clinical data tradename pregnancy category legal status routes of administration Pharmacokinetic data bioavailability metabolism elimination half life excretion Identifiers CAS number 22292 91 7 CAS supplemental br 34256 91 2 hydrochloride ATC prefix None ATC suffix PubChem 31117 ChemSpiderID 28874 UNII Ref fdacite correct FDA UNII 752168P7XM Chemical data C 18 H 21 N 1 O 2 molecular weight 283.36 g mol smiles OC43Oc2c c1ccccc1cc2 CC4CN CC3C C Naranol W 5494A is an antidepressant , anxiolytic , and antipsychotic with a tricyclic like chemical structure which was chemical synthesis synthesized in the late 1960s, but was never marketed. ref name isbn0 412 46630 9 cite book author David J. Triggle title Dictionary of pharmacological agents publisher Chapman & Hall location London year 1997 pages isbn 0 412 46630 9 oclc doi url http books.google.com books?id A0THacd46ZsC&lpg PA1401&dq naranol&f false ref See also Tricyclic References Reflist Antidepressants Anxiolytics Antipsychotics Tricyclics Category Alcohols Category Antipsychotics Category Anxiolytics Category Tricyclic antidepressants Category Ketals Category Piperidines ... more details
Drugbox IUPAC name 5 3 dimethylamino propyl 10,11 dihydro 5 H dibenzo b,f azepine 3 carbonitrile image Cianopramine.png Clinical data tradename pregnancy category legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers CAS number 66834 24 0 ATC prefix none ATC suffix PubChem 48126 ChemSpiderID 43782 UNII Ref fdacite correct FDA UNII 02MNR4P2PM Chemical data C 20 H 23 N 3 molecular weight 305.417 g mol smiles N Cc1ccc3c c1 N c2ccccc2CC3 CCCN C C InChI 1 C20H23N3 c1 22 2 12 5 13 23 19 7 4 3 6 17 19 10 11 18 9 8 16 15 21 14 20 18 23 h3 4,6 9,14H,5,10 13H2,1 2H3 InChIKey LQXYCDLHSKICDY UHFFFAOYAT Cianopramine Ro 11 2465 , also known as 3 cyanoimipramine , is a tricyclic antidepressant which is related to imipramine and acts as a serotonin reuptake inhibitor ref Kenny M, Lenehan TJ, Lambe R, Darragh A, Brick I, Omer LM. Effects of a single oral dose of 3 cyano imipramine on serotonin uptake and content of platelets in healthy volunteers. Psychopharmacology Berlin . 1983 79 4 304 7. PMID 6407042 ref and weak 5 HT receptor serotonin receptor Receptor antagonist antagonist . ref Paw owski L, Kwiatek H, G rka Z. Is Ro 11 2465 cyan imipramine an antagonist of postsynaptic serotonin receptors? Journal of Neural Transmission . 1981 52 1 2 61 72. PMID 7288439 ref See also Tricyclic antidepressant References Reflist 2 Antidepressants Anxiolytics Adrenergics Cholinergics Histaminergics Serotonergics Tricyclics Category Tricyclic antidepressants Category Serotonin antagonists Category Selective serotonin reuptake inhibitors Category Nitriles Category Dibenzazepines nervous system drug stub de Cianopramin ... more details
Drugbox IUPAC name 3 1a,10b dihydrod ibenzo a, e cyclopr opa c cyc lohepten 6 1 H yli dene N m ethyl 1 p ropanamine image Intriptyline.png Clinical data tradename pregnancy category legal status routes of administration Pharmacokinetic data bioavailability metabolism elimination half life excretion Identifiers CAS number 27466 27 9 ATC prefix none ATC suffix PubChem 71397 ChemSpiderID 64489 UNII Ref fdacite correct FDA UNII GU9MLT8VE0 Chemical data C 21 H 19 N 1 molecular weight 285.38 g mol smiles C C C C3 c1ccccc1 C C c2c3cccc2 CN C C Intriptyline is a tricyclic antidepressant TCA that was never marketed. ref name urlDictionary of pharmacological agents Google Books cite book url http books.google.com ?id A0THacd46ZsC&lpg PA1140&dq intriptyline 20antidepressant 20 triptyline 20 amitriptyline&pg PA1140 v onepage&q intriptyline 20antidepressant 20 triptyline 20 amitriptyline&f false title Dictionary of pharmacological agents Google Books isbn 9780412466304 author1 r Ganellin first1 C last2 j Triggle first2 D last3 MacDonald first3 F. year 1997 ref Synthesis File Intriptyline synth.png 400px Cite journal doi 10.1021 jm50018a008 title The Effect of Alkyl Substitution in Drugs V. Synthesis and Chemical Properties of Some Dibenzo a,d 1,4 cycloheptadienyl Ethers year 1961 last1 Van Der Stelt first1 C. last2 Harms first2 A. F. last3 Nauta first3 W. Th. journal Journal of Medicinal Chemistry volume 4 pages 335 issue 2 See also Tricyclic antidepressant References Reflist 2 Antidepressants Anxiolytics Adrenergics Cholinergics Histaminergics Serotonergics Tricyclics Category Tricyclic antidepressants Category Alkynes Category Dibenzocycloheptenes nervous system drug stub ... more details
Drugbox IUPAC name 1a,10b dihydrodibenzo a,e cyclopropa c cyclohepten 6 1 H one O 2 aminoethyl oxime image Mariptiline.png Clinical data tradename pregnancy category legal status routes of administration Pharmacokinetic data bioavailability metabolism elimination half life excretion Identifiers CAS number 60070 14 6 ATC prefix none ATC suffix PubChem 44203 ChemSpiderID 40222 UNII Ref fdacite correct FDA UNII E27T357050 Chemical data C 18 H 18 N 2 O 1 molecular weight 278.35 g mol smiles O N C2 c1c cccc1 C4CC4c3c2cccc3 CCN Mariptiline EN 207 is a tricyclic antidepressant TCA which was developed in the early 1980s, but was never marketed. ref name isbn0 412 46630 9 cite book author David J. Triggle title Dictionary of pharmacological agents publisher Chapman & Hall location London year 1997 pages isbn 0 412 46630 9 oclc doi url http books.google.com books?id A0THacd46ZsC&lpg PA1254&dq mariptiline&pg PA1254 v onepage&q mariptiline&f false ref ref name isbn0 12 040517 2 cite book author Hans Jurgen Hess title Annual Reports in Medicinal Chemistry Volume 17 publisher Academic Press location Boston year 1982 pages 400 isbn 0 12 040517 2 oclc doi url http books.google.com books?id gprdTFMiho4C&lpg PA41&dq mariptiline&pg PA41 v onepage&q mariptiline&f false ref See also Tricyclic antidepressant References Reflist Antidepressants Tricyclics Category Amines Category Dibenzocycloheptenes Category Oximes Category Tricyclic antidepressants ... more details
Encyclopedia
top
