enzyme Name ribose 5 phosphate isomerase EC number 5.3.1.6 CAS number 9023 83 0 IUBMB EC number 5 3 1 6 GO code 0004751 image width caption Ribose 5 phosphate isomerase Rpi is an enzyme that catalyzes the conversion between ribose 5 phosphate R5P and ribulose 5 phosphate Ru5P . Structure and catalysis In the reaction, the overall consequence is the movement of a carbonyl group from carbon number 1 to carbon number 2 this is achieved by the reaction going through an enediol intermediate Figure 1 . ref cite journal doi 10.1016 S0969 2126 02 00933 4 title Structure of Escherichia coli Ribose 5 Phosphate Isomerase A Ubiquitous Enzyme of the Pentose Phosphate Pathway and the Calvin Cycle year 2003 author Zhang, R journal Structure volume 11 pages 31 42 pmid 12517338 last2 Andersson first2 CE last3 Savchenko first3 A last4 Skarina first4 T last5 Evdokimova first5 E last6 Beasley first6 S last7 Arrowsmith first7 CH last8 Edwards first8 AM last9 Joachimiak first9 A issue 1 pmc 2792023 ref Through site directed mutagenesis , Asp87 of spinach RpiA was suggested to play the role of a general base in the interconversion of R5P to Ru5P. ref cite journal doi 10.1074 jbc.M508696200 year 2006 month ... isomerase from spinach heterologous overexpression, purification, characterization, and site ... cycle OPPP enzyme ribose 5 phosphate isomerase EC 5.3.1.6 from spinach chloroplasts year 1996 .... Rpi Deficiency Ribose 5 phosphate isomerase deficiency is mutated in a rare disorder, Ribose 5 phosphate isomerase deficiency RpiA and the Malaria Parasite RpiA generated attention when the enzyme ..., Ms title Ribose 5 Phosphate Isomerase Deficiency New Inborn Error in the Pentose Phosphate Pathway ... Pentose phosphate isomerase and epimerase from animal tissues journal Biochem. J. volume 64 pages 567 ... DEFAULTSORT Ribose 5 Phosphate Isomerase Category EC 5.3.1 Category Enzymes of known structure de Ribose 5 phosphat Isomerase ... more details
Cis trans isomerase is a type of isomerase which catalyzes the isomerization of geometric isomers . Examples include photoisomerase and immunophilins such as cyclophilin . External links MeshName cis trans Isomerases br Enzymes Topoisomerases enzyme stub Category Isomerases ... more details
enzyme Name D lyxose ketol isomerase EC number 5.3.1.15 CAS number 37318 42 6 IUBMB EC number 5 3 1 15 GO code 0047828 image width caption In enzymology , a D lyxose ketol isomerase EC number 5.3.1.15 is an enzyme that catalysis catalyzes the chemical reaction D lyxose math rightleftharpoons math D xylulose Hence, this enzyme has one substrate biochemistry substrate , D lyxose , and one product chemistry product , D xylulose . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s interconverting aldose s and ketose s. The systematic name of this enzyme class is D lyxose aldose ketose isomerase . Other names in common use include D lyxose isomerase , and D lyxose ketol isomerase . This enzyme participates in pentose and glucuronate interconversions . Structural studies As of late 2007, two tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1QO2 and PDB link 1VZW . References reflist 1 cite journal author ANDERSON RL, ALLISON DP date 1965 title PURIFICATION AND CHARACTERIZATION OF D LYXOSE ISOMERASE journal J. Biol. Chem. volume 240 pages 2367&ndash 72 pmid 14304839 isomerase stub Category EC 5.3.1 Category Enzymes of known structure ... more details
enzyme Name 2 chloro 4 carboxymethylenebut 2 en 1,4 olide isomerase EC number 5.2.1.10 CAS number 115629 29 3 IUBMB EC number 5 2 1 10 GO code 0047466 image width caption In enzymology , a 2 chloro 4 carboxymethylenebut 2 en 1,4 olide isomerase EC number 5.2.1.10 is an enzyme that catalysis catalyzes the chemical reaction cis 2 chloro 4 carboxymethylenebut 2 en 1,4 olide math rightleftharpoons math trans 2 chloro 4 carboxymethylenebut 2 en 1,4 olide Hence, this enzyme has one substrate biochemistry substrate , cis 2 chloro 4 carboxymethylenebut 2 en 1,4 olide , and one product chemistry product , trans 2 chloro 4 carboxymethylenebut 2 en 1,4 olide . This enzyme belongs to the family of isomerase s, specifically Cis trans isomerism cis trans isomerases . The systematic name of this enzyme class is 2 chloro 4 carboxymethylenebut 2 en 1,4 olide cis trans isomerase . Other names in common use include 2 chlorocarboxymethylenebutenolide isomerase , and chlorodienelactone isomerase . This enzyme participates in 1,4 dichlorobenzene degradation . References reflist 1 cite journal author Schwien U, Schmidt E, Knackmuss H J and Reinecke W date 1988 title Degradation of chlorosubstituted aromatic compounds by Pseudomonas sp. strain B13 fate of 3,5 dichlorocatechol journal Arch. Microbiol. volume 150 pages 78&ndash 84 doi 10.1007 BF00409721 isomerase stub Category EC 5.2.1 Category Enzymes of unknown structure ... more details
enzyme Name aconitate delta isomerase EC number 5.3.3.7 CAS number 37318 48 2 IUBMB EC number 5 3 3 7 GO code 0047614 image width caption In enzymology , an aconitate Delta isomerase EC number 5.3.3.7 is an enzyme that catalysis catalyzes the chemical reaction trans aconitate math rightleftharpoons math cis aconitate Hence, this enzyme has one substrate biochemistry substrate , trans aconitate , and one product chemistry product , cis aconitate . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s transposing C C bonds. The systematic name of this enzyme class is aconitate Delta2 Delta3 isomerase . This enzyme is also called aconitate isomerase . References reflist 1 cite journal author Klinman JP and Rose IA date 1971 title Purification and kinetic properties of aconitate isomerase from Pseudomonas putida journal Biochemistry volume 10 issue 12 pages 2253&ndash 2259 doi 10.1021 bi00788a011 pmid 5114987 cite journal author Klinman JP, Rose IA date 1971 title Mechanism of the aconitate isomerase reaction journal Biochemistry. volume 10 pages 2259&ndash 66 pmid 5114988 doi 10.1021 bi00788a012 issue 12 isomerase stub Intramolecular oxidoreductases Category EC 5.3.3 Category Enzymes of unknown structure ... more details
enzyme Name cholestenol delta isomerase EC number 5.3.3.5 CAS number 37318 47 1 IUBMB EC number 5 3 3 5 GO code 0047750 image width caption In enzymology , a cholestenol Delta isomerase EC number 5.3.3.5 is an enzyme that catalysis catalyzes the chemical reaction 5alpha cholest 7 en 3beta ol math rightleftharpoons math 5alpha cholest 8 en 3beta ol Hence, this enzyme has one substrate biochemistry substrate , 5alpha cholest 7 en 3beta ol , and one product chemistry product , 5alpha cholest 8 en 3beta ol . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductases transposing C C bonds. The systematic name of this enzyme class is Delta7 cholestenol Delta7 Delta8 isomerase . This enzyme participates in biosynthesis of steroids . References reflist 1 cite journal author Wilton DC, Rahimtula AD, Akhtar M date 1969 title The reversibility of the delta8 cholestenol delta7 cholestenol isomerase reaction in cholesterol biosynthesis journal Biochem. J. volume 114 pages 71&ndash 3 pmid 5810070 issue 1 pmc 1184797 isomerase stub Intramolecular oxidoreductases Category EC 5.3.3 Category Enzymes of unknown structure ... more details
enzyme Name dopachrome isomerase EC number 5.3.3.12 CAS number 130122 81 5 IUBMB EC number 5 3 3 12 GO code 0004167 image width caption In enzymology , a L dopachrome isomerase EC number 5.3.3.12 is an enzyme that catalysis catalyzes the chemical reaction L dopachrome math rightleftharpoons math 5,6 dihydroxyindole 2 carboxylate Hence, this enzyme has one substrate biochemistry substrate , L dopachrome , and one product chemistry product , 5,6 dihydroxyindole 2 carboxylate . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s transposing C C bonds. The systematic name of this enzyme class is L dopachrome keto enol isomerase . Other names in common use include dopachrome tautomerase , tyrosinase related protein 2 , TRP 1 , TRP2 , TRP 2 , tyrosinase related protein 2 , dopachrome Delta7,Delta2 isomerase , dopachrome Delta isomerase , dopachrome conversion factor , dopachrome isomerase , dopachrome oxidoreductase , dopachrome rearranging enzyme , DCF , DCT , dopachrome keto enol isomerase , and L dopachrome methyl ester tautomerase . This enzyme participates in tyrosine metabolism and melanogenesis . References reflist 1 cite journal author Jara JR, Lozano JA date Pt 2 title Molecular mechanism for catalysis by a new zinc enzyme, dopachrome tautomerase journal Biochem. J. volume 313 pages 447&ndash 53 pmid 8573077 pmc 1216928 cite journal author Pawelek JM date 1990 title Dopachrome conversion factor functions as an isomerase journal Biochem. Biophys. Res. Commun. volume 166 pages 1328&ndash 33 pmid 2106316 doi 10.1016 0006 291X 90 91011 G issue 3 cite journal author Joshua GW, Selkirk ME, Zhang Y, Meyer DJ date Pt 3 title Rapid purification and characterization of L dopachrome methyl ester tautomerase macrophage migration inhibitory factor from Trichinella spiralis, Trichuris muris and Brugia pahangi journal Biochem. J. volume 335 pages 495&ndash 8 pmid 9794786 pmc 1219807 isomerase stub Intramolecular oxidoreductases Category ... more details
enzyme Name dodecenoyl CoA delta isomerase EC number 5.3.3.8 CAS number 62213 29 0 IUBMB EC number 5 3 3 8 GO code 0004165 image width caption Orphan date February 2009 In enzymology , a dodecenoyl CoA isomerase EC number 5.3.3.8 is an enzyme that catalysis catalyzes the chemical reaction 3Z dodec 3 enoyl CoA math rightleftharpoons math 2E dodec 2 enoyl CoA Hence, this enzyme has one substrate biochemistry substrate , 3Z dodec 3 enoyl CoA , and one product chemistry product , 2E dodec 2 enoyl CoA . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s transposing C C bonds. The systematic name of this enzyme class is dodecenoyl CoA 3Z 2E isomerase . Other names in common use include dodecenoyl CoA Delta isomerase , Delta3 cis Delta2 trans enoyl CoA isomerase , acetylene allene isomerase , dodecenoyl CoA Delta isomerase , and dodecenoyl CoA Delta3 cis Delta2 trans isomerase . This enzyme participates in fatty acid metabolism . Structural studies As of late 2007, 12 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1HNO , PDB link 1HNU , PDB link 1K39 , PDB link 1PJH , PDB link 1SG4 , PDB link 1WDK , PDB link 1WDL , PDB link 1WDM , PDB link 1XX4 , PDB link 2CQU , PDB link 2D3T , and PDB link 2F6Q . References reflist 1 cite journal author Miesowicz FM, Bloch K date 1979 title Purification of hog liver isomerase. Mechanism of isomerization of 3 alkenyl and 3 alkynyl thioesters journal J. Biol. Chem. volume 254 pages 5868&ndash 77 pmid 376522 issue 13 cite journal ... trans Enoyl CoA isomerase from rat liver mitochondria journal Methods Enzymol. volume 14 pages ... Stoffel W, Grol M date 1978 title Purification and properties of 3 cis 2 trans enoyl CoA isomerase dodecenoyl CoA delta isomerase from rat liver mitochondria journal Hoppe. Seylers. Z. Physiol. Chem. volume 359 pages 1777&ndash 82 pmid 738702 issue 12 isomerase stub Category EC 5.3.3 Category Enzymes ... more details
enzyme Name corticosteroid side chain isomerase EC number 5.3.1.21 CAS number 75139 73 0 IUBMB EC number 5 3 1 21 GO code 0004110 image width caption In enzymology , a corticosteroid side chain isomerase EC number 5.3.1.21 is an enzyme that catalysis catalyzes the chemical reaction 11 deoxycorticosterone math rightleftharpoons math 20 hydroxy 3 oxopregn 4 en 21 al Hence, this enzyme has one substrate biochemistry substrate , 11 deoxycorticosterone , and one product chemistry product , 20 hydroxy 3 oxopregn 4 en 21 al . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s interconverting aldoses and ketoses. The systematic name of this enzyme class is 11 deoxycorticosterone aldose ketose isomerase . References reflist 1 cite journal author Martin KO, Oh SW, Lee HJ, Monder C date 1977 title Studies on 21 3H labeled corticosteroids evidence for isomerization of the ketol side chain of 11 deoxycorticosterone by a hamster liver enzyme journal Biochemistry. volume 16 pages 3803&ndash 9 pmid 901753 doi 10.1021 bi00636a013 issue 17 cite journal author Monder C, Martin KO, Bogumil J date 1980 title Presence of epimerase activity in hamster liver corticosteroid side chain isomerase journal J. Biol. Chem. volume 255 pages 7192&ndash 8 pmid 7391077 issue 15 isomerase stub Category EC 5.3.1 Category Enzymes of unknown structure ... more details
enzyme Name methylitaconate delta isomerase EC number 5.3.3.6 CAS number 9059 08 9 IUBMB EC number 5 3 3 6 GO code 0050100 image width caption In enzymology , a methylitaconate Delta isomerase EC number 5.3.3.6 is an enzyme that catalysis catalyzes the chemical reaction methylitaconate math rightleftharpoons math 2,3 dimethylmaleate Hence, this enzyme has one substrate biochemistry substrate , methylitaconate , and one product chemistry product , 2,3 dimethylmaleate . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s transposing C C bonds. The systematic name of this enzyme class is methylitaconate Delta2 Delta3 isomerase . This enzyme is also called methylitaconate isomerase . This enzyme participates in c5 branched dibasic acid metabolism . References reflist 1 cite journal author Kung HF, Stadtman TC date 1971 title Nicotinic acid metabolism. VI. Purification and properties of alpha methyleneglutarate mutase B 12 dependent and methylitaconate isomerase journal J. Biol. Chem. volume 246 pages 3378&ndash 88 pmid 5574401 issue 10 isomerase stub Intramolecular oxidoreductases Category EC 5.3.3 Category Enzymes of unknown structure ... more details
enzyme Name L rhamnose isomerase EC number 5.3.1.14 CAS number 9023 84 1 IUBMB EC number 5 3 1 14 GO code 0008740 image width caption In enzymology , a L rhamnose isomerase EC number 5.3.1.14 is an enzyme that catalysis catalyzes the chemical reaction L rhamnose math rightleftharpoons math L rhamnulose Hence, this enzyme has one substrate biochemistry substrate , L rhamnose , and one product chemistry product , L rhamnulose . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s interconverting aldose s and ketose s. The systematic name of this enzyme class is L rhamnose aldose ketose isomerase . Other names in common use include rhamnose isomerase , and L rhamnose ketol isomerase . This enzyme participates in fructose and mannose metabolism . Structural studies As of late 2007, 6 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1D8W , PDB link 1DE5 , PDB link 1DE6 , PDB link 2HCV , PDB link 2I56 , and PDB link 2I57 . References reflist 1 cite journal author DOMAGK GF, ZECH R date 1963 title ON THE DECOMPOSITION OF DESOXY SUGARS BY BACTERIAL ENZYMES. I L RHAMNOSE ISOMERASE FROM LACTOBACILLUS PLANTARUM. journal Biochem. Z. volume 339 pages 145&ndash 53 pmid 14095156 isomerase stub Category EC 5.3.1 Category Enzymes of known structure ja L ... more details
enzyme Name isopiperitenone delta isomerase EC number 5.3.3.11 CAS number 96595 07 2 IUBMB EC number 5 3 3 11 GO code 0050008 image width caption In enzymology , an isopiperitenone Delta isomerase EC number 5.3.3.11 is an enzyme that catalysis catalyzes the chemical reaction isopiperitenone math rightleftharpoons math piperitenone Hence, this enzyme has one substrate biochemistry substrate , isopiperitenone , and one product chemistry product , piperitenone . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s transposing C C bonds. The systematic name of this enzyme class is isopiperitenone Delta8 Delta4 isomerase . References reflist 1 cite journal author Kjonaas RB, Venkatachalam KV, Croteau R date 1985 title Metabolism of monoterpenes oxidation of isopiperitenol to isopiperitenone, and subsequent isomerization to piperitenone by soluble enzyme preparations from peppermint Mentha piperita leaves journal Arch. Biochem. Biophys. volume 238 pages 49&ndash 60 pmid 3885858 doi 10.1016 0003 9861 85 90139 0 issue 1 Category EC 5.3.3 Category Enzymes of unknown structure isomerase stub Intramolecular oxidoreductases ... more details
protein Name isopentenyl diphosphate delta isomerase 1 caption image width HGNCid 5387 Symbol IDI1 AltSymbols EntrezGene 3422 OMIM 604055 RefSeq NM 004508 UniProt Q13907 PDB ECnumber 5.3.3.2 Chromosome 10 Arm p Band 15.3 LocusSupplementaryData Isopentenyl diphosphate delta isomerase or isopentenyl pyrophosphate isomerase IPP isomerase is an isomerase which catalysis catalyzes the conversion of the relatively un reactive isopentenyl pyrophosphate IPP to the more reactive electrophile dimethylallyl ... through the mevalonate pathway . Enzyme Mechanism IPP isomerase catalyzes the isomerization of IPP ... isomerase mechanism.png frame none alt IPP isomerase mechanism The mechanism for the isomerization between ... IPP isomerase structure with active sites highlighted.png thumb right A cartoon diagram of human IPP isomerase with the catalytic cysteine residue Cys87 in red and the catalytic glutamic acid residue ... have observed that the active form of IPP isomerase is a monomer with alternating alpha helix ... 17250851 ref The active site of IPP isomerase is deeply buried within the enzyme and consists of a glutamic ... of a water molecule in the active site of human IPP isomerase, suggesting a mechanism where ... to protonation by water. ref name Zhang Cite pmid 17137593 ref IPP isomerase also requires ..., highlighting the unique catalytic mechanism of IPP isomerase. The isomerization of IPP to DMAPP ... ref Because of the importance of the melavonate pathway in isoprenoid biosynthesis, IPP isomerase is found ... for IPP isomerase 1, have been implicated in decreased viability in a number of organisms, including ... gain near two IPP isomerase genes in a substantial proportion of patients with sporadic amyotrophic lateral sclerosis , suggesting that the isomerase may play a role in this disease. ref name Kato ... delta isomerase Intramolecular oxidoreductases Mevalonate pathway Category EC 5.3.3 de Isopentenyldiphosphat Isomerase fi Isopentenyylipyrofosfaatti isomeraasi ... more details
enzyme Name 5 carboxymethyl 2 hydroxymuconate delta isomerase EC number 5.3.3.10 CAS number 79079 05 3 IUBMB EC number 5 3 3 10 GO code 0008704 image width caption In enzymology , a 5 carboxymethyl 2 hydroxymuconate Delta isomerase EC number 5.3.3.10 is an enzyme that catalysis catalyzes the chemical reaction 5 carboxymethyl 2 hydroxymuconate math rightleftharpoons math 5 carboxy 2 oxohept 3 enedioate Hence, this enzyme has one substrate biochemistry substrate , 5 carboxymethyl 2 hydroxymuconate , and one product chemistry product , 5 carboxy 2 oxohept 3 enedioate . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s transposing C C bonds. The systematic name of this enzyme class is 5 carboxymethyl 2 hydroxymuconate Delta2,Delta4 2 oxo,Delta3 isomerase . This enzyme participates in tyrosine metabolism and benzoate degradation via hydroxylation . Structural studies As of late 2007, 4 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1GTT , PDB link 1I7O , PDB link 1WZO , and PDB link 2DFU . References reflist 1 cite journal doi 10.1111 j.1432 1033.1981.tb06377.x author Garrido Pertierra A and Cooper RA date 1981 title Identification and purification of distinct isomerase and decarboxylase enzymes involved in the 4 hydroxyphenylacetate pathway of Escherichia coli journal Eur. J. Biochem. volume 117 issue 3 pages 581&ndash 584 pmid 7026235 isomerase stub Intramolecular oxidoreductases Category EC 5.3.3 Category Enzymes of known structure ... more details
enzyme Name prostaglandin A1 delta isomerase EC number 5.3.3.9 CAS number 9055 01 0 IUBMB EC number 5 3 3 9 GO code 0050219 image width caption In enzymology , a prostaglandin A1 Delta isomerase EC number 5.3.3.9 is an enzyme that catalysis catalyzes the chemical reaction 13E 15S 15 hydroxy 9 oxoprosta 10,13 dienoate math rightleftharpoons math 13E 15S 15 hydroxy 9 oxoprosta 11,13 dienoate Hence, this enzyme has one substrate biochemistry substrate , 13E 15S 15 hydroxy 9 oxoprosta 10,13 dienoate Prostaglandin A1 or PGA1 , and one product chemistry product , 13E 15S 15 hydroxy 9 oxoprosta 11,13 dienoate Prostaglandin C1 . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s transposing C C bonds. The systematic name of this enzyme class is 13E 15S 15 hydroxy 9 oxoprosta 10,13 dienoate Delta10 Delta11 isomerase . This enzyme is also called prostaglandin A isomerase . References reflist 1 cite journal author Polet H, Levine L date 1975 title Metabolism of prostaglandins E, A, and C in serum journal J. Biol. Chem. volume 250 pages 351&ndash 7 pmid 234423 issue 2 isomerase stub Intramolecular oxidoreductases Category EC 5.3.3 Category Enzymes of unknown structure ... more details
enzyme Name styrene oxide isomerase EC number 5.3.99.7 CAS number 124541 89 5 IUBMB EC number 5 3 99 7 GO code 0018846 image width caption In enzymology , a styrene oxide isomerase EC number 5.3.99.7 is an enzyme that catalysis catalyzes the chemical reaction styrene oxide math rightleftharpoons math phenylacetaldehyde Hence, this enzyme has one substrate biochemistry substrate , styrene oxide , and one product chemistry product , phenylacetaldehyde . This enzyme belongs to the family of isomerase s, specifically a class of other intramolecular oxidoreductase s. The systematic name of this enzyme class is styrene oxide isomerase epoxide cleaving . This enzyme is also called SOI . This enzyme participates in styrene degradation . References reflist 1 cite journal author Hartmans S, Smits JP, van der Werf MJ, Volkering F, de Bont JA date 1989 title Metabolism of Styrene Oxide and 2 Phenylethanol in the Styrene Degrading Xanthobacter Strain 124X journal Appl. Environ. Microbiol. volume 55 pages 2850&ndash 2855 pmid 16348047 issue 11 pmc 203180 isomerase stub Category EC 5.3.99 Category Enzymes of unknown structure ... more details
enzyme Name vinylacetyl CoA delta isomerase EC number 5.3.3.3 CAS number 9023 73 8 IUBMB EC number 5 3 3 3 GO code 0050393 image width caption In enzymology , a vinylacetyl CoA Delta isomerase EC number 5.3.3.3 is an enzyme that catalysis catalyzes the chemical reaction vinylacetyl CoA math rightleftharpoons math crotonyl CoA Hence, this enzyme has one substrate biochemistry substrate , vinylacetyl CoA , and one product chemistry product , crotonyl CoA . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s transposing C C bonds. The systematic name of this enzyme class is vinylacetyl CoA Delta3 Delta2 isomerase . Other names in common use include vinylacetyl coenzyme A Delta isomerase , vinylacetyl coenzyme A isomerase , and Delta3 cis Delta2 trans enoyl CoA isomerase . This enzyme participates in butanoate metabolism . Structural studies As of late 2007, only one tertiary structure structure has been solved for this class of enzymes, with the Protein Data Bank PDB accession code PDB link 1U8V . References reflist 1 cite journal author Lynen F, Knappe J, Lorch E, Jutting G and Ringelmann E date 1959 title Die biochemische Funktion des Biotins journal Angew. Chem. volume 71 pages 481&ndash 486 doi 10.1002 ange.19590711503 issue 15 16 cite journal author Rilling HC and Coon MJ date 1960 title The enzymatic isomerization of beta methylvinylacetyl coenzyme A and the specificity of a bacterial beta methylcrotonyl coenzyme A carboxylase journal J. Biol. Chem. volume 235 pages 3087&ndash 3092 isomerase stub Intramolecular oxidoreductases Category EC 5.3.3 Category Enzymes of known structure ... more details
enzyme Name L fucose isomerase EC number 5.3.1.25 CAS number 60063 83 4 IUBMB EC number 5 3 1 25 GO code 0008736 image width caption Infobox protein family Symbol Fucose iso N1 Name L fucose isomerase, first N terminal domain image PDB 1fui EBI.jpg width caption l fucose isomerase from escherichia coli Pfam PF07881 Pfam clan InterPro IPR012888 SMART PROSITE MEROPS SCOP 1fui TCDB OPM family OPM protein CAZy CDD Infobox protein family Symbol Fucose iso N2 Name L fucose isomerase, second N terminal domain image PDB 1fui EBI.jpg width caption l fucose isomerase from escherichia coli Pfam PF07882 Pfam clan InterPro IPR012889 SMART PROSITE MEROPS SCOP 1fui TCDB OPM family OPM protein CAZy CDD Infobox protein family Symbol Fucose iso C Name L fucose isomerase, C terminal domain image PDB 1fui EBI.jpg width caption l fucose isomerase from escherichia coli Pfam PF02952 Pfam clan CL0393 InterPro IPR015888 SMART PROSITE MEROPS SCOP 1fui TCDB OPM family OPM protein CAZy CDD In enzymology , a L fucose isomerase EC number 5.3.1.25 is an enzyme that catalysis catalyzes the chemical reaction L fucose math rightleftharpoons math L fuculose Hence, this enzyme has one substrate biochemistry substrate , L fucose , and one product chemistry product , L fuculose . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s interconverting aldose s and ketose s. The systematic name of this enzyme class is L fucose aldose ketose isomerase . This enzyme participates in fructose and mannose metabolism . The enzyme is a hexamer, forming the largest structurally known ketol isomerase , and has no sequence biology sequence or secondary structure structural similarity with other ketol isomerases. The secondary structure structure was determined by X ray crystallography ... title Structure and mechanism of L fucose isomerase from Escherichia coli journal J. Mol. Biol. volume ... 4 pmid 2664711 doi 10.1093 nar 17.12.4883 issue 12 pmc 318048 isomerase stub InterPro content IPR015888 ... more details
protein Name mannose 6 phosphate isomerase caption image Deleted image removed File phosphomannoseisomerase.png thumb Phosphomannose Isomerase visualized with Pymol width HGNCid 7216 Symbol MPI, PMI AltSymbols ... 15 Arm q Band 22 LocusSupplementaryData qter Mannose 6 phosphate isomerase MPI , alternately phosphomannose isomerase PMI EC 5.3.1.8 is an enzyme which facilitates the interconversion of fructose 6 phosphate F6P and mannose 6 phosphate M6P . Mannose 6 Phosphate Isomerase may also enable the synthesis of GDP mannose in eukaryotic organisms. M6P can be converted to F6P by Mannose 6 Phosphate Isomerase ... biosynthesis ref EBI Database, IPRO16305 Mannose 6 phosphate Isomerase. http www.ebi.ac.uk ..., H., Yu, Y., Leary, JA. Mechanism and Kinetics of metalloenzyme phosphomannose isomerase measurement ..., Y. Chu, F., Sun, P. Computational study of human phosphomannose isomerase Insights from homology ... of mannose 6 phosphate isomerase from Salmonella typhimurium bound to metal atoms and substrate ... of the mechanism of phosphomannose isomerase may be found in the 1968 Journal of Biological Chemistry ... 5410.full.pdf html Studies on Phosphomannose Isomerase A Mechanism for Catalysis and for the Role of Zinc .... ref Rose, I., O Connell, E., Schray, K. Mannose 6 Phosphate Anomeric Form used by Phosphomannose Isomerase and Its 1 Epimerization by Phosphoglucose Isomerase. American Society of Biological Chemists, October 13 1972. http www.jbc.org content 248 6 2232.full.pdf html ref Phosphoglucose Isomerase PGI ... Anomeric Form used by Phosphomannose Isomerase and Its 1 Epimerization by Phosphoglucose Isomerase ... Phosphoglucose Isomerase. ePub May 10 2008. http ctc.xmu.edu.cn zxcao ruibo pic PGI JACS.pdf ref ... differs from phosphoglucose isomerase by a threonine residue Thr291 which creates extra space in the active ... Isomerase ref Swan, M., Hansen, T., Schonheit, P., Davies, C. Structural Basis for Phosphomannose Isomerase Activity in Phosphoglucose Isomerase from Pyrobaculum Aerophilum A Subtle Difference between ... more details
enzyme Name isopentenyl diphosphate delta isomerase EC number 5.3.3.2 CAS number 9033 27 6 IUBMB EC number 5 3 3 2 GO code 0004452 image width caption In enzymology , an isopentenyl diphosphate Delta isomerase EC number 5.3.3.2 is an enzyme that catalysis catalyzes the chemical reaction isopentenyl diphosphate math rightleftharpoons math dimethylallyl diphosphate Hence, this enzyme has one substrate biochemistry substrate , isopentenyl diphosphate , and one product chemistry product , dimethylallyl diphosphate . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s transposing C C bonds. The systematic name of this enzyme class is isopentenyl diphosphate Delta3 Delta2 isomerase . Other names in common use include isopentenylpyrophosphate Delta isomerase , methylbutenylpyrophosphate isomerase , and isopentenylpyrophosphate isomerase . This enzyme participates in biosynthesis of steroids and terpenoid biosynthesis . Structural studies As of late 2007, 25 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1HX3 , PDB link 1HZT , PDB link 1I9A , PDB link 1NFS , PDB link 1NFZ , PDB link 1OW2 , PDB link 1P0K , PDB link 1P0N , PDB link 1PPV , PDB link 1PPW , PDB link 1PVF , PDB link 1Q54 , PDB link 1R67 , PDB link 1VCF , PDB link 1VCG , PDB link 1X83 , PDB link 1X84 , PDB link 2B2K , PDB link 2DHO , PDB link 2G73 , PDB link 2G74 , PDB link 2I6K , PDB link 2ICJ , PDB link 2ICK , and PDB link 2PNY . References reflist 1 cite journal author Kaneda K, Kuzuyama T, Takagi M, Hayakawa Y, Seto H date 2001 title An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190 journal Proc. Natl. Acad. Sci. U.S.A. ... pyrophosphate isomerase journal J. Biol. Chem. volume 235 pages 326&ndash 32 pmid 13792054 Category EC 5.3.3 Category Enzymes of known structure Category Article Feedback 5 isomerase stub ... more details
enzyme Name L arabinose isomerase EC number 5.3.1.4 CAS number 9023 80 7 IUBMB EC number 5 3 1 4 GO code 0008733 image width caption Infobox protein family Symbol Arabinose Isome Name Arabinose isomerase image PDB 2ajt EBI.jpg width caption crystal structure of l arabinose isomerase from e.coli Pfam PF02610 Pfam clan InterPro IPR003762 SMART PROSITE MEROPS SCOP TCDB OPM family OPM protein CAZy CDD In enzymology , a L arabinose isomerase EC number 5.3.1.4 is an enzyme that catalysis catalyzes the chemical reaction L arabinose math rightleftharpoons math L ribulose Hence, this enzyme has one substrate biochemistry substrate , L arabinose , and one product chemistry product , L ribulose . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s interconverting aldose s and ketose s. The systematic name of this enzyme class is L arabinose aldose ketose isomerase . This enzyme participates in pentose and glucuronate interconversions . This enzyme catalyses the coversion of L arabinose to L ribulose as the first step in the pathway of L arabinose utilization as a carbon source. ref name pmid9084180 cite journal author Sa Nogueira I, Nogueira TV, Soares S, de Lencastre H title The Bacillus subtilis L arabinose ara operon nucleotide sequence, genetic organization and expression journal Microbiology Reading, Engl. volume 143 issue 3 pages 957 69 year 1997 month March pmid 9084180 doi url ref Structural studies As of late 2007, two tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 2AJT and PDB link 2HXG . References reflist Further reading reflist 1 cite journal author ... plantarum. II. L arabinose isomerase journal J. Biol. Chem. volume 231 pages 1031&ndash 7 pmid ... of L arabinose isomerase from Lactobacillus gayonii journal Biochim. Biophys. Acta. volume 178 pages 156&ndash 65 pmid 5773448 issue 1 isomerase stub InterPro content IPR003762 Category Protein ... more details
protein Name Enoyl CoA Isomerase caption image width Symbol DCI ECnumber 5.3.3.8 UniProt P42126 DrugBank DB03211 Chromosome 16 Arm p Band 13.3 LocusSupplementaryData Enoyl CoA isomerase , also known as dodecenoyl CoA isomerase , 3,2 trans enoyl CoA isomerase , 3 cis , 2 trans enoyl CoA isomerase , or acetylene allene isomerase , ref name refname1 EC number 5.3.3.8 is an enzyme that catalyzes the conversion ... Mechanism of Enoyl CoA Isomerase Enoyl CoA isomerase is involved in the beta oxidation , one ... CoA isomerase is technically required for their metabolism as well. ref name refname3 The reaction ... site of enoyl coA isomerase . As it functions in the step immediately preceding the actual beta oxidation and forms a double bond extending from the beta carbon position 2 , enoyl CoA isomerase ... classes of enoyl CoA isomerase s and the C terminal domain works as a dehydrogenase , specifically ... Enzyme structure All classes of enoyl CoA isomerase s belong to a family of enzyme s, the hydratase isomerase or crotonase superfamily, and when examined with x ray crystallography , exhibit a common ..., each turn consisting of two beta sheet s and one alpha helix . ref name refname8 In enoyl CoA isomerase ... reaction. ref name refname4 File Catalytic Site on Enoyl CoA Isomerase in Yeast.png thumb Figure 2 Catalytic Sites of Enoyl CoA Isomerase in Yeast Moreover, a glutamate Amino acid residue located ... of Enoyl CoA Isomerase in Yeast.png thumb Figure 3 Trimer Disk of Enoyl CoA Isomerase in Yeast The NH ... on the enzyme can be compared in Figure 2. ref name refname4 The enzyme s of the hydratase isomerase .... ref name refname9 However, the human mitochondrial enoyl CoA isomerase is a trimer chemistry trimer ... cerevisiae is displayed in Figure 3. ref name refname9 Enzyme history Enoyl CoA isomerase was first ... exchange chromatography . ref name refname10 Since then, all classes of enoyl CoA isomerase , mitochondrial ... more mammal s, plant s, and unicellular organisms. By 1994, using the rat enoyl CoA isomerase cDNA ... more details
enzyme Name Polyenoic fatty acid isomerase EC number 5.3.3.13 CAS number IUBMB EC number 5 3 3 13 GO code image width caption In enzymology , a polyenoic fatty acid isomerase EC number 5.3.3.13 is an enzyme that catalysis catalyzes the chemical reaction 5Z,8Z,11Z,14Z,17Z icosapentaenoate math rightleftharpoons math 5Z,7E,9E,14Z,17Z icosapentaenoate Hence, this enzyme has one substrate biochemistry substrate , 5Z,8Z,11Z,14Z,17Z icosapentaenoate , and one product chemistry product , 5Z,7E,9E,14Z,17Z icosapentaenoate . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s transposing C C bonds. The systematic name of this enzyme class is 5Z,8Z,11Z,14Z,17Z icosapentaenoate Delta8,11 Delta7,9 isomerase trans double bond forming . Other names in common use include PFI , eicosapentaenoate cis Delta5,8,11,14,17 eicosapentaenoate , cis Delta5 trans Delta7,9 cis Delta14,17 isomerase , 5Z,8Z,11Z,14Z,17Z eicosapentaenoate Delta8,11 Delta7,8 isomerase , incorrect , 5Z,8Z,11Z,14Z,17Z eicosapentaenoate Delta8,11 Delta7,9 isomerase , and trans double bond forming . References reflist 1 cite journal author Wise ML, Hamberg M, William H. Gerwick Gerwick WH date 1994 title Biosynthesis of conjugated triene containing fatty acids by a novel isomerase from the red marine alga Ptilota filicina journal Biochemistry. volume 33 pages 15223&ndash 32 pmid 7803384 doi 10.1021 bi00255a002 issue 51 cite journal author Wise ML, Soderstrom K, Murray TF, William H. Gerwick Gerwick WH date 1996 title Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid journal Experientia. volume 52 pages 88&ndash 92 pmid 8575565 ... WH date 1997 title Characterization of the substrate binding site of polyenoic fatty acid isomerase ... JG, Yuan L, William H. Gerwick Gerwick WH date 2002 title Polyenoic fatty acid isomerase from the marine ... 00002 4 issue 1 isomerase stub Intramolecular oxidoreductases Category EC 5.3.3 Category Enzymes of unknown ... more details
Infobox protein family Symbol KduI Name KduI IolB family image PDB 1ywk EBI.jpg width caption crystal structure of 4 deoxy 1 threo 5 hexosulose uronate ketol isomerase from enterococcus faecalis Pfam PF04962 Pfam clan CL0029 InterPro IPR021120 SMART PROSITE MEROPS SCOP TCDB OPM family OPM protein CAZy CDD In molecular biology, the KduI IolB isomerase family is a protein family family of isomerase enzymes . The family includes 4 deoxy L threo 5 hexosulose uronate ketol isomerase 5 keto 4 deoxyuronate isomerase KduI and 5 deoxy glucuronate isomerase 5DG isomerase IolB . KduI is involved in pectin degradation by free living soil bacteria that use pectin as a carbon source, breaking it down to 2 keto 3 deoxygluconate, which can ultimately be converted to pyruvate . KduI catalysis catalyses the fourth step in pectin degradation, namely the interconversion of 5 keto 4 deoxyuronate and 2,5 diketo 3 dexoygluconate. ref name pmid1766386 cite journal author Condemine G, Robert Baudouy J title Analysis of an Erwinia chrysanthemi gene cluster involved in pectin degradation journal Mol. Microbiol. volume 5 issue 9 pages 2191 202 year 1991 month September pmid 1766386 doi url ref KduI has a TIM barrel TIM barrel protein folding fold . ref name pmid16152643 cite journal author Crowther RL, Georgiadis MM title The crystal structure of 5 keto 4 deoxyuronate isomerase from Escherichia coli journal Proteins volume 61 issue 3 pages 680 4 year 2005 month November pmid 16152643 doi 10.1002 prot.20598 url ref This family also includes several bacteria bacterial Myo inositol catabolism proteins, such as IolB, which is encoded by the inositol operon iolABCDEFGHIJ in Bacillus subtilis . IolB is involved in myo inositol catabolism. Glucose repression of the iol operon induced by inositol is exerted through catabolite repression mediated by CcpA and the iol induction system mediated by IolR. ref name pmid11566986 cite journal author Miwa Y, Fujita Y title Involvement of two distinct catabolite ... more details
enzyme Name muconolactone delta isomerase EC number 5.3.3.4 CAS number 37318 46 0 IUBMB EC number 5 3 3 4 GO code 0016159 image width caption In enzymology , a muconolactone Delta isomerase EC number 5.3.3.4 is an enzyme that catalysis catalyzes the chemical reaction S 5 oxo 2,5 dihydrofuran 2 acetate math rightleftharpoons math 5 oxo 4,5 dihydrofuran 2 acetate Hence, this enzyme has one substrate biochemistry substrate , S 5 oxo 2,5 dihydrofuran 2 acetate , and one product chemistry product , 5 oxo 4,5 dihydrofuran 2 acetate . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s transposing C C bonds. The systematic name of this enzyme class is 5 oxo 4,5 dihydrofuran 2 acetate Delta3 Delta2 isomerase . This enzyme is also called muconolactone isomerase . This enzyme participates in benzoate degradation via hydroxylation . Structural studies As of late 2007, only one tertiary structure structure has been solved for this class of enzymes, with the Protein Data Bank PDB accession code PDB link 1MLI . References reflist 1 cite journal author Ornston LN date 1966 title The conversion of catechol and protocatechuate to beta ketoadipate by Pseudomonas putida. 3. Enzymes of the catechol pathway journal J. Biol. Chem. volume 241 pages 3795&ndash 9 pmid 5330966 issue 16 cite journal author Ornston LN date 1970 title Conversion of catechol and protocatechuate to beta ketoadipate Pseudomonas putida journal Methods Enzymol. volume 17A pages 529&ndash 549 isomerase stub Intramolecular oxidoreductases Category EC 5.3.3 Category Enzymes of known structure ... more details
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